A diol form of (±)12

(±)12(13)-DiHOME – 25 µg

Brand:
Cayman
CAS:
263399-35-5
Storage:
-20
UN-No:
De Minimis - 1231 / 3

(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME (Item No. 52450), a cytochrome P450-derived epoxide of linoleic acid (Item Nos. 90150 | 90150.1 | 21909) also known as isoleukotoxin.{8529} It is formed from 12(13)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils.{17057} 12(13)-DiHOME is toxic to Sf21 cells expressing sEH and to lacZ-expressing control cells, unlike isoleukotoxin, which is only toxic to cells containing sEH.{8529,17057} Levels of 12(13)-DiHOME are increased in rat spinal cord following burn injury, and it enhances cold tolerance, increases fatty acid uptake into brown adipocytes, and decreases serum triglyceride levels in mice.{35412,34553} Levels are also elevated in bronchoalveolar lavage fluid (BALF) in humans following exposure to biodiesel exhaust and in exhaled breath condensate in patients with allergic asthma following allergen exposure.{42556,42557} Plasma levels of 12(13)-DiHOME are increased immediately following moderate-intensity exercise in mice and humans, an effect that can be prevented by brown adipose tissue removal in the mouse.{35413}  

 

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SKU: 10009832 - 25 µg Category:

Description

A diol form of (±)12,13-EpOME; toxic to Sf21 cells expressing sEH and to lacZ-expressing control cells; rat spinal cord levels are increased following burn injury; BALF levels are elevated in humans following exposure to biodiesel exhaust and in exhaled breath condensate in patients with allergic asthma following allergen exposure; plasma levels are increased immediately following moderate-intensity exercise in mice and humans

Formal name: 12,13-dihydroxy-9Z-octadecenoic acid

Synonyms:  Isoleukotoxin diol

Molecular weight: 314.5

CAS: 263399-35-5

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Octadecanoids||Research Area|Cardiovascular System|Lipids & Lipoproteins||Research Area|Endocrinology & Metabolism|Thermogenesis||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways||Research Area|Neuroscience||Research Area|Toxicology

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