A racemic version of a CYP450 metabolite of arachidonic acid; produced as two R/S enantiomers; plays a role in the recovery of depleted calcium pools in cultured smooth muscle cells; inhibits basolateral 18-pS potassium channels in the renal cortical collecting duct (100 nM); increases isolated peripheral blood leukocyte adhesion (50 µg/kg per day)

(±)11(12)-EET – 500 µg

Brand:
Cayman
CAS:
123931-40-8
Storage:
-20
UN-No:
Excepted Quantity - 1170 / 3

(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid (Item No. 90010) by cytochrome P450 enzymes.{463,729,39722} A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET.{39722} 11(12)-EET has been shown, along with 8(9)-EET (Item No. 50351), to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells.{5318} It also inhibits basolateral 18-pS potassium channels in the renal cortical collecting duct when used at a concentration of 100 nM.{39723} 11(12)-EET (50 µg/kg per day) increases adhesion of isolated peripheral blood leukocytes in a chamber coated with P-selectin and ICAM-1 but does not affect choroidal neovascularization size following laser photocoagulation.{39724} It also has anti-inflammatory, angiogenic, and cardioprotective properties.{39725}  

 

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SKU: 50511 - 500 µg Category:

Description

A racemic version of a CYP450 metabolite of arachidonic acid; produced as two R/S enantiomers; plays a role in the recovery of depleted calcium pools in cultured smooth muscle cells; inhibits basolateral 18-pS potassium channels in the renal cortical collecting duct (100 nM); increases isolated peripheral blood leukocyte adhesion (50 µg/kg per day)

Formal name: (±)11,(12)-epoxy-5Z,8Z,14Z-eicosatrienoic acid

Synonyms:  (±)11,12-EpETrE

Molecular weight: 320.5

CAS: 123931-40-8

Purity: ≥95%

Formulation: A solution in ethanol

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