An ω-3 endocannabinoid epoxide and CB receptor agonist (EC50s = 0.43 and 22.5 nM for CB1 and CB2 receptors

(±)10(11)-EDP Ethanolamide – 50 µg

Brand:
Cayman
CAS:
2123484-71-7
Storage:
-20
UN-No:
- 1170 / 3

(±)10(11)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 0.43 and 22.5 nM for CB1 and CB2 receptors, respectively).{42488} It is produced though direct epoxygenation of docosahexaenoyl ethanolamide (DHEA; Item No. 10007534) by cytochrome P450 (CYP) epoxygenases.{42488,40186} 10,11-EDP epoxide (12.5 and 25 μM) reduces the viability of 143B metastatic osteosarcoma cells.{42488} It induces apoptosis and inhibits cell migration in a wound-healing assay in 143B, MG63, and HOS osteosarcoma cells. (±)10(11)-EDP ethanolamide also reduces tube formation by human umbilical vein endothelial cells (HUVECs) in a Matrigel™ assay.  

 

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SKU: 25878 - 50 µg Category:

Description

An ω-3 endocannabinoid epoxide and CB receptor agonist (EC50s = 0.43 and 22.5 nM for CB1 and CB2 receptors, respectively); reduces the viability of 143B metastatic osteosarcoma cells at 12.5 and 25 μM; induces apoptosis and inhibits cell migration in a wound-healing assay in 143B, MG63, and HOS osteosarcoma cells; reduces tube formation by HUVECs in a Matrigel™ assay,

Formal name: N-(2-hydroxyethyl)-9-[3-(2Z,5Z,8Z)-2,5,8-undecatrien-1-yl-2-oxiranyl]-4Z,7Z-nonadienamide

Synonyms:  10,11-EDP epoxide|10,11-EDP-EA|10,11-epoxy Docosapentaenoic Ethanolamide

Molecular weight: 387.6

CAS: 2123484-71-7

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Product Type|Biochemicals|Lipids|Fatty Amides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Neuroscience|Cannabinoid Research

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