A GVIA iPLA2 inhibitor (IC50 = 1 nM); selective for GVIA iPLA2 over GVIA cPLA2 (IC50 = 22 μM); inhibits apoptosis induced by IL-1β and IFN-γ in INS-1 β-cells at 1 and 10 μM

(±)-trans-GK563 – 1 mg

Brand:
Cayman
CAS:
2351820-19-2
Storage:
-20
UN-No:
Excepted Quantity - 1231 / 3

trans-(±)-GK563 is a potent β-lactone inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (GVIA iPLA2; IC50 = 1 nM).{35898} It is selective for GVIA iPLA2 over GVIA cPLA2 (IC50 = 22 μM). trans-(±)-GK563 (1 and 10 μM) inhibits apoptosis induced by IL-1β and IFN-γ in INS-1 β-cells.  

 

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SKU: 25732 - 1 mg Category:

Description

A GVIA iPLA2 inhibitor (IC50 = 1 nM); selective for GVIA iPLA2 over GVIA cPLA2 (IC50 = 22 μM); inhibits apoptosis induced by IL-1β and IFN-γ in INS-1 β-cells at 1 and 10 μM

Formal name: (3R,4R)-rel-3-(4-phenylbutyl)-4-propyl-2-oxetanone

Synonyms:  GK563

Molecular weight: 246.3

CAS: 2351820-19-2

Purity: ≥94%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Small Molecule Inhibitors|Phospholipases||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Lipid Biochemistry|Glycerophospholipids|Phospholipases

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