An agonist of mGluRs (EC50s = 15

(±)-trans-ACPD – 25 mg

Brand:
Cayman
CAS:
67684-64-4
Storage:
-20
UN-No:
Non-Hazardous - /

(±)-trans-ACPD is an agonist of metabotropic glutamate receptors (mGluRs; EC50s = 15, 2, 40, 23, and 82 µM for mGluR1, -2, -3, -5, and -6, respectively, in CHO cells expressing recombinant receptors).{47711} It also activates mGluR4 in baby hamster kidney cells with an EC50 value of approximately 800 µM. (±)-trans-ACPD increases cAMP accumulation in adult rat cerebral cortex slices (EC50 = 47.8 µM) but not in isolated rat embryonic neurons or neonatal glial cells when used at concentrations ranging from 1 to 1,000 µM.{47712} (±)-trans-ACPD (10-1,000 µM) increases phosphoinositide hydrolysis in neonatal rat cerebral cortex and hippocampal slices. It induces clonic convulsions in neonatal rats (ED50 = 100 mg/kg), an effect that can be reversed by administration of the NMDA receptor antagonists LY233053 and LY274614.{47713}  

 

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SKU: 28849 - 25 mg Category:

Description

An agonist of mGluRs (EC50s = 15, 2, 40, 23, and 82 µM for mGluR1, -2, -3, -5, and -6, respectively, in CHO cells expressing recombinant receptors, and ~800 µM for mGluR4 in baby hamster kidney cells); increases cAMP accumulation in adult rat cerebral cortex slices (EC50 = 47.8 µM) but not in isolated rat embryonic neurons or neonatal glial cells at 1-1,000 µM; increases phosphoinositide hydrolysis in neonatal rat cerebral cortex and hippocampal slices at 10-1,000 µM; induces convulsions in neonatal rats (ED50 = 100 mg/kg), an effect that can be reversed by administration of the NMDA receptor antagonists LY233053 and LY274614

Formal name: (1R,3S)-1-aminocyclopentane-1,3-dicarboxylic acid

Synonyms: 

Molecular weight: 173.2

CAS: 67684-64-4

Purity: ≥95%

Formulation: A crystalline solid

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