An immunomodulatory compound with diverse biological activities; prevents PMN chemotaxis at 1

(±)-Thalidomide – 1 g

Brand:
Cayman
CAS:
50-35-1
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

(±)-Thalidomide is an immunomodulatory compound with diverse biological activities, including anticancer, anti-inflammatory, and teratogenic properties.{54394,54393,54392} It prevents polymorphonuclear leukocyte (PMN) chemotaxis when used at concentrations of 1, 10, and 100 µg/ml.{54394} (±)-Thalidomide increases IL-2-induced proliferation and IFN-γ production in primary human T cells in vitro.{54393} It enhances natural killer (NK) cell-mediated cytotoxicity in MM.1S multiple myeloma cells.{54392} Thalidomide (4 mg/animal) reduces lung IL-6, TGF-β, VEGF, angiopoietin-1, angiopoietin-2, and collagen type Iα1 expression, inhibits pulmonary angiogenesis, and attenuates fibrosis in a mouse model of bleomycin-induced pulmonary fibrosis.{54395} It induces apoptosis in primary human embryonic fibroblasts (EC50 = 8.9 µM) and induces limb and eye defects in chicken embryos (EC50 = 50 µg/kg egg weight).{54396} Formulations containing thalidomide have been used in the treatment of multiple myeloma and erythema nodosum leprosum (ENL) in non-pregnant individuals.  

 

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An immunomodulatory compound with diverse biological activities; prevents PMN chemotaxis at 1, 10, and 100 µg/ml; increases IL-2-induced proliferation and IFN-γ production in primary human T cells in vitro; enhances NK cell-mediated cytotoxicity in MM.1S multiple myeloma cells; reduces lung IL-6, TGF-β, VEGF, angiopoietin-1, angiopoietin-2, and collagen type Iα1 expression, inhibits pulmonary angiogenesis, and attenuates fibrosis in a mouse model of bleomycin-induced pulmonary fibrosis at 4 mg/animal; induces apoptosis in primary human embryonic fibroblasts (EC50 = 8.9 µM) and induces limb and eye defects in chicken embryos (EC50 = 50 µg/kg egg weight)

Formal name: 2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

Synonyms:  N-Phthaloylglutamimide|NSC 527179|NSC 66847

Molecular weight: 258.2

CAS: 50-35-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death||Research Area|Cancer|Immunology||Research Area|Cardiovascular System|Vasculature|Angiogenesis||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Immunology & Inflammation|Pulmonary Diseases||Research Area|Toxicology|Cell Health & Viability

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