A flavonoid with diverse biological activities; scavenges DPPH radicals in cell-free assays; cytotoxic to HCT116 cells (IC50 = 63.42 µM); inhibits HMG-CoA reductase activity and cholesterol synthesis in HepG2 cells at 200 µM; reduces carrageenan-induced paw edema in rats (ED50 = 12.9 mg/kg)

(±)-Taxifolin – 250 mg

Brand:
Cayman
CAS:
24198-97-8
Storage:
-20
UN-No:
Non-Hazardous - /

(±)-Taxifolin is a flavonoid that has been found in M. butyracea and has diverse biological activities.{56219,30238,30239,30237} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in cell-free assays.{56219} (±)-Taxifolin is cytotoxic to HCT116 cells (IC50 = 63.42 µM).{30238} It inhibits HMG-CoA reductase activity and cholesterol synthesis in HepG2 cells by 47 and 86%, respectively, when used at a concentration of 200 µM.{30239} In vivo, (±)-taxifolin reduces carrageenan-induced paw edema in rats (ED50 = 12.9 mg/kg).{32037}  

 

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Description

A flavonoid with diverse biological activities; scavenges DPPH radicals in cell-free assays; cytotoxic to HCT116 cells (IC50 = 63.42 µM); inhibits HMG-CoA reductase activity and cholesterol synthesis in HepG2 cells at 200 µM; reduces carrageenan-induced paw edema in rats (ED50 = 12.9 mg/kg)

Formal name: (2R,3R)-rel-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one

Synonyms:  (±)-Dihydroquercetin

Molecular weight: 304.3

CAS: 24198-97-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Cancer|Cell Death||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Immunology & Inflammation||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic

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