A selective agonist of the dopamine D1-like receptor (Ki = 1.9 nM) that demonstrates comparatively lower binding affinity for the dopamine D2

(±)-SKF 81297 (hydrobromide) – 10 mg

Brand:
Cayman
CAS:
67287-39-2
Storage:
-20
UN-No:
Non-Hazardous - /

(±)-SKF 81297 is a selective agonist of the dopamine D1-like receptor (Ki = 1.9 nM).{24103} It demonstrates comparatively lower binding affinity for the dopamine D2, dopamine D3, serotonin 5-HT2A, and adrenergic α2 receptors (Kis = 1,272, >10,000, 955, and 509 nM, respectively).{24103} Activation of dopamine D1-like receptors by selective agonists such as (±)-SKF 81297 have been implicated in initiating a cascade of signaling events leading to reward-related incentive learning.{24104}  

 

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Description

A selective agonist of the dopamine D1-like receptor (Ki = 1.9 nM) that demonstrates comparatively lower binding affinity for the dopamine D2, dopamine D3, serotonin 5-HT2A, and adrenergic α2 receptors (Kis = 1,272, >10,000, 955, and 509 nM, respectively)

Formal name: 6-​chloro-​2,​3,​4,​5-​tetrahydro-​1-​phenyl-1H-​3-​benzazepine-​7,​8-​diol, monohydrobromide

Synonyms:  (±)-6-chloro-PB

Molecular weight: 370.7

CAS: 67287-39-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience

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