A sodium channel opener that prolongs the open state of cardiac voltage-gated Na+ channels

(±)-SDZ-201 106 – 25 mg

Brand:
Cayman
CAS:
97730-95-5
Storage:
-20
UN-No:
Non-Hazardous - /

(±)-SDZ-201 106 is a diphenylpiperazinylindole derivative that prolongs the open state of cardiac voltage-gated Na+ channels. It has been shown to increase net Na+ influx and the activity of reverse mode Na+/Ca2+ exchange, which leads to an increase in intracellular Ca2+, as well as to partially inhibit the Na+ pump in cardiac myocytes.{33343} (±)-SDZ-201 106 is also reported to act as an open-channel blocker of delayed-rectifier K+ channels in NG108-15 neuronal cells.{33344}  

 

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Description

A sodium channel opener that prolongs the open state of cardiac voltage-gated Na+ channels, increases intracellular Ca2+, and partially inhibits the Na+ pump in cardiac myocytes

Formal name: 4-[3-[4-(diphenylmethyl)-1-piperazinyl]-2-hydroxypropoxy]-1H-indole-2-carbonitrile

Synonyms:  DPI 201-106

Molecular weight: 466.6

CAS: 97730-95-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Heart

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