An IDO pathway inhibitor (Ki = 7 nM; EC50 = 75 nM); inhibits IDO-induced T cell suppression and restores T cell response during allogenic mixed lymphocyte reactions in vitro; induces a 95% reduction in tumor volume when given in conjunction with a pmel-1 T cell vaccine in vivo

(±)-NLG-919 – 5 mg

Brand:
Cayman
CAS:
1402836-58-1
Storage:
-20
UN-No:
Non-Hazardous - /

(±)-NLG-919 is an indoleamine 2,3-dioxygenase (IDO) pathway inhibitor (Ki = 7 nM; EC50 = 75 nM).{38170} (±)-NLG-919 inhibits IDO-induced T cell suppression and restores T cell response during allogenic mixed lymphocyte reactions in vitro (ED50s = 80 and 120 nM, respectively). In vivo, (±)-NLG-919 induces a 95% reduction in tumor volume when administered in conjunction with a pmel-1 T cell vaccine. Formulations containing (±)-NLG-919 are under investigation in clinical trials for treatment of glioblastoma, melanoma, pancreatic, and breast cancers.{38171}  

 

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Description

An IDO pathway inhibitor (Ki = 7 nM; EC50 = 75 nM); inhibits IDO-induced T cell suppression and restores T cell response during allogenic mixed lymphocyte reactions in vitro; induces a 95% reduction in tumor volume when given in conjunction with a pmel-1 T cell vaccine in vivo ,

Formal name: α-cyclohexyl-5H-imidazo[5,1-a]isoindole-5-ethanol

Synonyms:  GDC-0919

Molecular weight: 282.4

CAS: 1402836-58-1

Purity: ≥98% (mixture of enantiomers)

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer||Research Area|Immunology & Inflammation|Adaptive Immunity

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