An internal standard for the quantification of (±)-nicotine by GC- or LC-MS

(±)-Nicotine-d3 – 10 mg

Brand:
Cayman
CAS:
69980-24-1
Storage:
-20
UN-No:
De Minimis - 1170 / 3

(±)-Nicotine-d3 is intended for use as an internal standard for the quantification of (±)-nicotine (Item No. 16535) by GC- or LC-mass spectrometry. (±)-Nicotine is the racemic mixture of the dominant alkaloid found in tobacco plants. It acts as an agonist at neuronal nicotinic acetylcholine receptors (nAChRs; Kis = 481 and 11.1 nM for α3β4 and α4β2 subtypes, respectively) and possesses addictive and teratogenic properties.{18814} (−)-(S)-Nicotine is significantly more active at binding nAChRs compared to the (+)-(R) antipode, thus nicotine is typically synthesized as (−)-(S)-nicotine with only 0.2-1% of the (+)-(R) isomer present.{26727}  

 

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Description

An internal standard for the quantification of (±)-nicotine by GC- or LC-MS

Formal name: 3-[1-(methyl-d3)-2-pyrrolidinyl]-pyridine

Synonyms:  ​(±)-Nicotine-methyl-d3|DL-Nicotine-d3

Molecular weight: 165.3

CAS: 69980-24-1

Purity: ≥99% deuterated forms (d1-d3)

Formulation: A solution in ethanol

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research

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