A monoterpene alcohol with diverse biological activities; induces cell cycle arrest at the G0/G1 and G2M phase in U937 and HeLa cells

(±)-Linalool – 10 mg

Brand:
Cayman
CAS:
78-70-6
Storage:
22
UN-No:
Non-Hazardous - /

(±)-Linalool is a monoterpene alcohol that has been found in C. sativa, C. indica, and hemp with diverse biological activities.{41453,21575,36770,36771,36772,42327} It induces cell cycle arrest at the G0/G1 and G2M phase in U937 and HeLa cells, respectively.{21575} (±)-Linalool is cytotoxic to U937 and HeLa cells (IC50s = 2.59 and 11.02 μM, respectively). It induces recruitment of a PGC-1α coactivator peptide to the PPARα ligand binding domain (EC50 = 5.45 μM in a TR-FRET assay).{36770} In vivo, (±)-linalool reduces plasma triglyceride concentration in mice fed a Western diet and transgenic mice expressing human ApoE2, but not PPARα-/- mice. It has molluscicidal and larvicidal effects in vitro (LC50s = 0.25 and 0.07 mg/L for O. hupensis and S. japonicium, respectively), and it reduces the amount of schitosomulum recovered from mouse skin after S. japonicium challenge infection.{36771} (±)-Linalool (10-40 mg/kg) reduces the number of macrophages and neutrophils and the production of TNF-α, IL-6, IL-1β, IL-8, and MCP-1 in bronchoalveolar lavage fluid (BALF) in a mouse model of cigarette smoke-induced acute lung inflammation.{36772} It also decreases immobility time in the forced swim test in mice, indicating antidepressant-like activity.{42327}  

 

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A monoterpene alcohol with diverse biological activities; induces cell cycle arrest at the G0/G1 and G2M phase in U937 and HeLa cells, respectively; cytotoxic to U937 and HeLa cells (IC50s = 2.59 and 11.02 μM, respectively); induces recruitment of a PGC-1α coactivator peptide to the PPARα ligand binding domain (EC50 = 5.45 μM in a TR-FRET assay); reduces plasma triglyceride concentration in mice fed a Western diet and transgenic mice expressing human ApoE2; has molluscicidal and larvicidal effects in vitro (LC50s = 0.25 and 0.07 mg/L for O. hupensis and S. japonicium, respectively); reduces the amount of schitosomulum recovered from mouse skin after S. japonicium challenge infection; reduces the number of macrophages and neutrophils and the production of TNF-α, IL-6, IL-1β, IL-8, and MCP-1 in BALF in a mouse model of cigarette smoke-induced acute lung inflammation from 10-40 mg/kg; decreases immobility time in the forced swim test in mice

Formal name: 3,7-dimethyl-1,6-octadien-3-ol

Synonyms:  dl-Linalool|NSC 3789

Molecular weight: 154.3

CAS: 78-70-6

Purity: ≥98%

Formulation: A liquid

Application||Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Natural Products|Phytocannabinoids||Product Type|Biochemicals|Natural Products|Terpenes||Research Area

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