An agonist of α4β2 subunit-containing nAChRs (Ki = 43 pM); selective for α4β2 subunit-containing nAChRs over α7 nAChRs (Ki = 230 nM); 86Rb+ flux in IMR-32 cells (EC50 = 7 nM); induces dopamine release from rat striatal slices (EC50 = 0.4 nM); induces analgesia in the hot plate test and the Straub-tail response in mice (ED50s = 0.005 and 0.02 mg/kg

(±)-Epibatidine (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
162885-01-0
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

(±)-Epibatidine is an alkaloid that has been found in Ecuadoran poison frog (E. tricolor) skin extracts and an agonist of α4β2 subunit-containing nicotinic acetylcholine receptors (nAChRs; Ki = 43 pM).{52706,52707} It is selective for α4β2 subunit-containing nAChRs over α7 nAChRs (Ki = 230 nM).{52706} (±)-Epibatidine enhances 86Rb+ flux in IMR-32 cells (EC50 = 7 nM) and induces dopamine release from rat striatal slices (EC50 = 0.4 nM), effects that can be reduced by the nAChR antagonist mecamylamine (Item No. 14602). In vivo, (±)-epibatidine induces analgesia in the hot plate test and the Straub-tail response in mice (ED50s = 0.005 and 0.02 mg/kg, respectively).{52707}  

 

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Description

An agonist of α4β2 subunit-containing nAChRs (Ki = 43 pM); selective for α4β2 subunit-containing nAChRs over α7 nAChRs (Ki = 230 nM); 86Rb+ flux in IMR-32 cells (EC50 = 7 nM); induces dopamine release from rat striatal slices (EC50 = 0.4 nM); induces analgesia in the hot plate test and the Straub-tail response in mice (ED50s = 0.005 and 0.02 mg/kg, respectively)

Formal name: (1R,2R,4S)-rel-2-(6-chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane, dihydrochloride

Synonyms: 

Molecular weight: 281.6

CAS: 162885-01-0

Purity: ≥98%

Formulation: A solid

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