An active metabolite of propranolol

(±)-4-hydroxy Propranolol (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
14133-90-5
Storage:
-20
UN-No:
Non-Hazardous - /

Propranolol inhibits β1-, β2-, and β3-adrenergic receptors with log KD values of -8.16, -9.08, and -6.93, respectively.{25151,25396} (±)-4-hydroxy Propranolol is an active metabolite of propranolol, inhibiting β1- and β2-adrenergic receptors with KD values of 2.4 and 5.8 nM, respectively.{30091,30093} It is comparable to propranolol in potency in antagonizing the effects of isoprenaline on heart rate and blood pressure in cats and dogs.{30091,30090} (±)-4-hydroxy Propranolol also has antioxidant properties at micromolar concentrations.{30092}  

 

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Description

An active metabolite of propranolol, inhibiting β1- and β2-adrenergic receptors with KD values of 2.4 and 5.8 nM, respectively; comparable to propranolol in potency in antagonizing the effects of isoprenaline on heart rate and blood pressure in cats and dogs

Formal name: 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-1-naphthalenol, monohydrochloride

Synonyms: 

Molecular weight: 311.8

CAS: 14133-90-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cardiovascular System|Cardiovascular Diseases|Angina||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Heart|Arrhythmia

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