Description
An enhancer of sphingolipid biosynthesis; increases glucosylceramide synthase activity by 4 and 8% when used at concentrations of 5 and 2.5 µM, respectively, in an enzyme assay; increases the activity of ganglioside GM3, GD3, and GQ1b synthases and increases the levels of glucosylceramide, lactosylceramide, and ganglioside GM3 in B16 melanoma cells; inhibits the growth of MCF-7, MDA-MB-468, SK-BR-3 cells (IC50s = 4, 7, and 6 µM, respectively); increases neurite outgrowth and synapse formation in vitro and improves retention of a long-term memory learned prior to forebrain ischemia in rats when administered following ischemia at 40 mg/kg per day
Formal name: N-[(1S,2S)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-decanamide, monohydrochloride
Synonyms:
Molecular weight: 427
CAS: 161491-04-9
Purity: ≥98%
Formulation: A solid
Product Type|Biochemicals|Small Molecule Activators||Research Area|Cancer||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders||Research Area|Neuroscience|Neuroprotection
