A sesquiterpene alcohol with diverse biological activities; inhibits proliferation of A549 and H1299 NSCLC cells over BEAS-2B normal lung cells (IC50s = 121.7

(−)-Guaiol – 25 mg

Brand:
Cayman
CAS:
489-86-1
Storage:
-20
UN-No:
Non-Hazardous - /

(−)-Guaiol is a sesquiterpene alcohol that has been found in several traditional Chinese medicinal plants and has antiproliferative, pro-autophagic, insect repellent, and insecticidal biological activities.{39874,39872,39873} It selectively inhibits proliferation of A549 and H1299 non-small cell lung carcinoma (NSCLC) cells over BEAS-2B normal lung cells (IC50s = 121.7, 211.5, and 297.1 μM, respectively).{39874} It also dose-dependently induces formation of DNA double-strand breaks (DSBs) and autophagy in A549 and H1299 cells and increases levels of microtubule-associated protein 1 light chain 3 isoform II (LC3-II). (−)-Guaiol (8 mg/kg three times per week) inhibits tumor growth in an NSCLC mouse xenograft model. It deters A. aegypti and A. quadrimaculatus mosquitoes from feeding on a synthetic blood substitute with a biting-deterrent index (BDI) of 0.82 when used at a concentration of 25 nmol per cm2.{39872} (−)-Guaiol is also lethal to fourth instar M. separata and third instar P. xylostella larvae (LD50s = 0.07 and 8.9 mg/larva, respectively).{39873}  

 

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SKU: 23172 - 25 mg Category:

Description

A sesquiterpene alcohol with diverse biological activities; inhibits proliferation of A549 and H1299 NSCLC cells over BEAS-2B normal lung cells (IC50s = 121.7, 211.5, and 297.1 μM, respectively); induces formation of DNA DSBs and autophagy in A549 and H1299 cells and increases levels of LC3-II; inhibits tumor growth in an NSCLC mouse xenograft model at 8 mg/kg three times per week; deters A. aegypti and A. quadrimaculatus mosquitoes from feeding on a synthetic blood substitute at 25 nmol per cm2; lethal to fourth instar M. separata and third instar P. xylostella larvae (LD50s = 0.07 and 8.9 mg/larva, respectively)

Formal name: (3S,5R,8S)-1,2,3,4,5,6,7,8-octahydro-α,α,3,8-tetramethyl-5-azulenemethanol

Synonyms:  NSC 19941

Molecular weight: 222.4

CAS: 489-86-1

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Cancer|Autophagy||Research Area|Cancer|DNA Damage and Repair||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy

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