A polyphenol with diverse biological activities; inhibits histamine release from anti-EA IgE antibody-sensitized rat peritoneal mast cells from 0.1 to 1 mg/ml; reduces proliferation of MDA-MB-231 breast cancer cells (IC50 = 22 μg/ml) and HUVECs; inhibits human placental aromatase activity (IC50 = 15 μM); lytic against T. cruzi amastigotes (MBC50 = 0.12 pM); decreases RAW 264.7 osteoclastogenesis at 20 μM

(−)-Gallocatechin Gallate – 5 mg

Brand:
Cayman
CAS:
4233-96-9
Storage:
-20
UN-No:
Non-Hazardous - /

(–)-Gallocatechin gallate ((–)-GCG) is a catechin polyphenol that has been found in oolong tea stems and green tea extracts with diverse biological activities.{37587,41815,37588,41816,37589} It inhibits histamine release from anti-egg albumin (EA) IgE antibody-sensitized rat peritoneal mast cells when used at concentrations ranging from 0.1 to 1 mg/ml.{37587} (–)-GCG reduces proliferation of MDA-MB-231 breast cancer cells (IC50 = 22 μg/ml) and human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner.{41815} It also inhibits human placental aromatase activity (IC50 = 15 μM).{37588} (–)-GCG is lytic against T. cruzi amastigotes, with a 50% bactericidal concentration (MBC50) value of 0.12 pM.{41816} It also decreases RAW 264.7 osteoclastogenesis when used at a concentration of 20 μM.{37589}  

 

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SKU: 24962 - 5 mg Category:

Description

A polyphenol with diverse biological activities; inhibits histamine release from anti-EA IgE antibody-sensitized rat peritoneal mast cells from 0.1 to 1 mg/ml; reduces proliferation of MDA-MB-231 breast cancer cells (IC50 = 22 μg/ml) and HUVECs; inhibits human placental aromatase activity (IC50 = 15 μM); lytic against T. cruzi amastigotes (MBC50 = 0.12 pM); decreases RAW 264.7 osteoclastogenesis at 20 μM

Formal name: 3,4,5-trihydroxy-benzoic acid, (2S,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester

Synonyms:  (–)-GCG|NVP-XAA225

Molecular weight: 458.4

CAS: 4233-96-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products|Polyphenols||Research Area|Cancer|Angiogenesis||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Chagas Disease

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