A polyphenol with diverse biological activities; inhibits proliferation of MDA-MB-231 breast cancer cells; reduces VEGF-induced tyrosine phosphorylation of VEGFR2; competitive inhibitor of GLUT4 (Ki = 90 μM); inhibits methylglucose uptake by isolated rat adipocytes (IC50 = 50 μM); lytic against T. cruzi amastigotes (MBC50 = 48 pM)

(−)-Catechin Gallate – 5 mg

Brand:
Cayman
CAS:
130405-40-2
Storage:
-20
UN-No:
Non-Hazardous - /

(–)-Catechin gallate ((–)-CG) is a catechin polyphenol that has been found in green tea extracts with diverse biological activities.{41817,41815,41818,41816} It inhibits proliferation of MDA-MB-231 breast cancer cells and reduces VEGF-induced tyrosine phosphorylation of VEGF receptor 2 (VEGFR2) in bovine aortic endothelial cells (BAECs) in a concentration-dependent manner.{41817,41815} (–)-CG is a competitive inhibitor of the facilitative glucose transporter GLUT4 (Ki = 90 μM) and inhibits methylglucose uptake by isolated rat adipocytes (IC50 = 50 μM).{41818} It is also lytic against T. cruzi amastigotes, with a 50% bactericidal concentration (MBC50) value of 48 pM.{41816}  

 

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SKU: 24963 - 5 mg Category:

Description

A polyphenol with diverse biological activities; inhibits proliferation of MDA-MB-231 breast cancer cells; reduces VEGF-induced tyrosine phosphorylation of VEGFR2; competitive inhibitor of GLUT4 (Ki = 90 μM); inhibits methylglucose uptake by isolated rat adipocytes (IC50 = 50 μM); lytic against T. cruzi amastigotes (MBC50 = 48 pM)

Formal name: 3,4,5-trihydroxy-(2S,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester, benzoic acid

Synonyms:  (–)-CG

Molecular weight: 442.4

CAS: 130405-40-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products|Catechins||Product Type|Biochemicals|Natural Products|Polyphenols||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Chagas Disease

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