A bicyclic monoterpene; a positive allosteric modulator of α1β2γ2L subunit-containing GABAA receptors (EC50 = 237 µM); increases the latency to first pentylenetetrazole- and maximal electroshock-induced seizure in mice at 50

(−)-Borneol – 50 mg

Brand:
Cayman
CAS:
464-45-9
Storage:
-20
UN-No:
De Minimis - 1312 / 4.1

(−)-Borneol is a bicyclic monoterpene originally found in A. canadense.{36773,36774} It is a positive allosteric modulator of α1β2γ2L subunit-containing GABAA receptors with an EC50 value of 237 µM for human recombinant receptors expressed in X. laevis oocytes.{36773} It increases the latency to first pentylenetetrazole- and maximal electroshock-induced seizure in mice when administered at doses of 50, 100, and 200 mg/kg.{36775} (–)-Borneol (300 mg/kg) also increases the permeability of the blood-brain barrier and increases the concentration of cisplatin reaching tumors in a mouse model of glioblastoma multiforme.{36776} Formulations containing (–)-borneol have been used as fragrance ingredients.  

 

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Description

A bicyclic monoterpene; a positive allosteric modulator of α1β2γ2L subunit-containing GABAA receptors (EC50 = 237 µM); increases the latency to first pentylenetetrazole- and maximal electroshock-induced seizure in mice at 50, 100, and 200 mg/kg; increases the permeability of the blood-brain barrier and increases the concentration of cisplatin reaching tumors in a mouse model of glioblastoma multiforme at 300 mg/kg

Formal name: (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol

Synonyms:  (1S)-(-)-Borneol|endo-(-)-Borneol|L-Borneol

Molecular weight: 154.3

CAS: 464-45-9

Purity: ≥95%

Formulation: A crystalline solid

Application||Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer||Research Area|Neuroscience|Seizure Disorders

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