A quinone which inhibits topoisomerase I at 25 μM and transglutaminase (IC50 = 5 μM); reduced to β-lapachone hydroquinone by NQO1

β-Lapachone – 5 mg

Brand:
Cayman
CAS:
4707-32-8
Storage:
-20
UN-No:
Non-Hazardous - /

β-Lapachone is a natural quinone with diverse anti-cancer and anti-inflammatory effects. It inhibits topoisomerase I at 25 μM and transglutaminase (IC50 = 5 μM).{22728,22726} In cancer cells which overexpress NAD(P)H:quinone oxidoreductase, β-lapachone is reduced to β-lapachone hydroquinone, which generates reactive oxygen species during its reversion to β-lapachone.{22729} This process sensitizes cancer cells to radiation, suppresses NF-κB activation, and drives apoptosis.{22729,22725,22727}  

 

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Description

A quinone which inhibits topoisomerase I at 25 μM and transglutaminase (IC50 = 5 μM); reduced to β-lapachone hydroquinone by NQO1, generating ROS during its reversion to β-lapachone; sensitizes cancer cells to radiation, suppresses NF-κB activation, and drives apoptosis

Formal name: 3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione

Synonyms:  ARQ 501|NSC 26326|NSC 629749|SL 11001

Molecular weight: 242.3

CAS: 4707-32-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|DNA Damage and Repair|Topoisomerase||Research Area|Cancer|Metabolism||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Immunology & Inflammation

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