A precursor of vitamin A; inhibits proliferation of GOTO human neuroblastoma cells more potently than β-carotene; halts the cell cycle at the G0/G1 phase and reduces mRNA expression of the protooncogene N-Myc; decreases the number of hepatomas in mice with spontaneous liver carcinogenesis (0.05% in drinking water)

α-Carotene – 500 µg

Brand:
Cayman
CAS:
7488-99-5
Storage:
-20
UN-No:
Non-Hazardous - /

α-Carotene is a precursor of vitamin A (Item No. 20241) that has been found in various fruits and vegetables.{41838} It inhibits proliferation of GOTO human neuroblastoma cells more potently than β-carotene (Item No. 16837) and halts the cell cycle at the G0/G1 phase concomitantly with a reduction in the mRNA expression of the protooncogene N-Myc.{41839} It is also more potent than β-carotene in mouse models of skin and lung carcinogenesis and decreases the number of hepatomas in mice with spontaneous liver carcinogenesis when administered in drinking water at a concentration of 0.05%.{41840} α-Carotene levels are increased in patients with coronary heart disease and are inversely correlated with the risk of estrogen receptor-negative breast cancer.{41841,41842}  

 

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Description

A precursor of vitamin A; inhibits proliferation of GOTO human neuroblastoma cells more potently than β-carotene; halts the cell cycle at the G0/G1 phase and reduces mRNA expression of the protooncogene N-Myc; decreases the number of hepatomas in mice with spontaneous liver carcinogenesis (0.05% in drinking water)

Formal name: (6’R)-β,ε-carotene

Synonyms:  all-trans-α-Carotene

Molecular weight: 536.9

CAS: 7488-99-5

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Lipids|Prenol Lipids||Product Type|Biochemicals|Natural Products||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Transcription Factors||Research Area|Cardiovascular System|Cardiovascular Diseases|Coronary Artery Disease||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins||Research Area|Lipid Biochemistry|Prenol Lipids

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