A component of certain essential oils used in traditional Chinese herbal medicine; carcinogenic

α-Asarone – 5 g

Brand:
Cayman
CAS:
2883-98-9
Storage:
-20
UN-No:
Non-Hazardous - /

α-Asarone is a component of certain essential oils used in traditional Chinese herbal medicine. Although carcinogenic, α-asarone has been shown to be neuroprotective and radioprotective in mice when given at 50 mg/kg.{21103,21108,21096} It also lowers serum cholesterol in rats, specifically reducing LDL-cholesterol levels and cholesterol saturation index, by directly inhibiting HMG-CoA reductase (IC50 = 3 mM).{21107,21098} α-Asarone also directly interacts with and inhibits certain isoforms of cytochrome P450 (IC50 = 55.2 and 65.2 μg/ml for CYP2D6 and CYP3A4, respectively).{21106}  

 

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SKU: 11681 - 5 g Category:

Description

A component of certain essential oils used in traditional Chinese herbal medicine; carcinogenic, neuroprotective, and radioprotective in mice when given at 50 mg/kg; inhibits HMG-CoA reductase (IC50 = 3 mM); inhibits CYP2D6 and CYP3A4 (IC50 = 55.2 and 65.2 μg/ml, respectively)

Formal name: 1,2,4-trimethoxy-5-(1E)-1-propen-1-yl-benzene

Synonyms:  trans-Asarone

Molecular weight: 208.3

CAS: 2883-98-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Lipid Biochemistry|Sterol Lipids||Research Area|Neuroscience|Neuroprotection||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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