A diol form of (±)9(10)-EpOME; toxic to Sf21 cells expressing sEH and to lacZ-expressing control cells; induces cell death in rabbit renal proximal tubule cells concomitant with mitochondrial respiration dysfunction and induces lung injury

(±)9(10)-DiHOME – 25 µg

Brand:
Cayman
CAS:
263399-34-4
Storage:
-20
UN-No:
De Minimis - 1231 / 3

(±)9(10)-DiHOME is the diol form of (±)9(10)-EpOME (Item No. 52400), a cytochrome P450-derived epoxide of linoleic acid (Item Nos. 90150 | 90150.1 | 21909) also known as leukotoxin.{8529} It is formed from 9(10)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils.{17057} It is toxic to Sf21 cells expressing sEH and to lacZ-expressing control cells, unlike leukotoxin, which is only toxic to cells containing sEH.{8529,17057} A mixture of 9(10)- and 12(13)-DiHOME induces cell death in rabbit renal proximal tubule cells concomitant with mitochondrial respiration dysfunction and induces lung injury, respiratory distress, and mortality in mice.{15651,5617} 9(10)-DiHOME is a toxic lipid mediator involved in acute respiratory distress syndrome (ARDS), a common and often fatal complication in severe burn victims.{17057,15651} Levels of 9(10)-DiHOME are increased in bronchoalveolar lavage fluid (BALF) from women, but not men, with chronic obstructive pulmonary disease (COPD).{42554} BALF levels are also increased in patients with allergic asthma following allergen exposure compared to patients without allergic asthma.{49189} It has been used as a plasma biomarker for sEH activity in vivo.{42555}  

 

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Description

A diol form of (±)9(10)-EpOME; toxic to Sf21 cells expressing sEH and to lacZ-expressing control cells; induces cell death in rabbit renal proximal tubule cells concomitant with mitochondrial respiration dysfunction and induces lung injury, respiratory distress, and mortality in mice when used in a mixture with 12(13)-DiHOME; a toxic lipid mediator involved in ARDS; levels are increased in BALF from women, but not men, with COPD; BALF levels are increased in patients with allergic asthma following allergen exposure; has been used as a plasma biomarker for sEH activity in vivo

Formal name: (±)9,10-dihydroxy-12Z-octadecenoic acid

Synonyms:  Leukotoxin diol

Molecular weight: 314.5

CAS: 263399-34-4

Purity: ≥98%

Formulation: A solution in methyl acetate

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