A novel CYP450 metabolite of 2-AG in the kidney; acts as a potent mitogen for renal epithelial cells

(±)2-(14,15-Epoxyeicosatrienoyl) Glycerol – 25 µg

Brand:
Cayman
CAS:
848667-56-1
Storage:
-80
UN-No:
Non-Hazardous - 1648 / 3

2-Arachidonoyl glycerol (2-AG) is an endogenous central cannabinoid (CB1) receptor agonist that is present at relatively high levels in the central nervous system.{7183,7182,6819} 2-AG is hydrolyzed by the enzyme monoacylglycerol lipase, terminating its biological activity, and metabolism by cyclooxygenase-2 and lipoxygenases has been documented.{11364,12168} The related endocannabinoid, 2-arachidonoyl ethanolamide (AEA), can be metabolized by cytochrome P450 (CYP450) enzymes in human liver and kidney to a number of epoxy-ethanolamide derivatives.{14767} (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol ((±)2-14,15-EG) is a novel CYP450 metabolite of 2-AG in the kidney.{14755} (±)2-14,15-EG is a potent mitogen for renal epithelial cells, increasing DNA synthesis in LLCPKcl4 cells at concentrations as low as 100 nM and doubling cell proliferation rates at 1 µM.{14755} In these cells, (±)2-14,15-EG activates the metalloprotease ADAM17, which cleaves proTGF-α and releases TGF-α as a ligand that initiates the EGFR-ERK signalling pathway.  

 

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Description

A novel CYP450 metabolite of 2-AG in the kidney; acts as a potent mitogen for renal epithelial cells, increasing DNA synthesis in LLCPKcl4 cells at concentrations as low as 100 nM and doubling cell proliferation rates at 1 µM

Formal name: (5Z,8Z,11Z)-13-(3-pentyl-2-oxiranyl)-5,8,11-tridecatrienoic acid, (±)2-hydroxy-1-(hydroxymethyl)ethyl ester

Synonyms:  (±)2-14,15-EG

Molecular weight: 394.5

CAS: 848667-56-1

Purity: ≥95%

Formulation: A solution in acetonitrile

Product Type|Biochemicals|Lipids|Glycerolipids||Product Type|Biochemicals|Small Molecule Activators||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways||Research Area|Lipid Biochemistry|Glycerolipids

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