An ω-3 endocannabinoid epoxide and CB receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2

(±)19(20)-EDP Ethanolamide – 50 µg

Brand:
Cayman
CAS:
2123485-34-5
Storage:
-20
UN-No:
- 1170 / 3

(±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). It is produced through direct epoxygenation of docosahexaenoyl ethanolamide (DHEA; Item No. 10007534) by cytochrome P450 (CYP) epoxygenases.{40186,42488} (±)19(20)-EDP ethanolamide (25 µM) reduces the viability of 143B metastatic osteosarcoma cells.{42488} It decreases the production of IL-6 and increases the production of IL-10 when used at concentrations ranging from 2.5 to 10 µM in BV-2 microglia stimulated by LPS and decreases LPS-induced cytotoxicity when used at concentrations ranging from 5 to 10 µM. It also decreases nitrite production when used at a concentration of 7.5 µM, an effect that can be partially reversed by the CB2 receptor antagonist AM630 (Item No. 10006974) and the PPARγ antagonist GW 9662 (Item No. 70785). (±)19(20)-EDP ethanolamide induces vasodilation of isolated preconstricted bovine coronary arteries (ED50 = 1.9 µM) and reduces tube formation by human microvascular endothelial cells (HMVECs) in a Matrigel™ assay.  

 

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SKU: 25917 - 50 µg Category:

Description

An ω-3 endocannabinoid epoxide and CB receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively); reduces the viability of 143B metastatic osteosarcoma cells at 25 µM; decreases the production of IL-6 and increases LPS-induced production of IL-10 in BV-2 microglia at 2.5-10 µM; decreases LPS-induced cytotoxicity in BV-2 microglia at 5-10 µM; decreases nitrite production at 7.5 µM, an effect that can be partially reversed by AM630 and GW 9662; induces vasodilation of isolated preconstricted bovine coronary arteries (ED50 = 1.9 µM); tube formation by HMVECs

Formal name: 18-(3-ethyl-2-oxiranyl)-N-(2-hydroxyethyl)-4Z,7Z,10Z,13Z,16Z-octadecapentaenamide

Synonyms:  19,20-DHEA epoxide|19,20-EDP epoxide|19,20-EDP-EA|19,20-epoxy Docosapentaenoic Acid Ethanolamide

Molecular weight: 387.6

CAS: 2123485-34-5

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Product Type|Biochemicals|Lipids|Fatty Amides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cardiovascular System|Vasculature|Angiogenesis||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids

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