The racemic version of a CYP450 metabolite of arachidonic acid that dose-dependently stimulates vasodilation of the rabbit kidney

(±)18-HETE – 100 µg

Brand:
Cayman
CAS:
133268-58-3
Storage:
-20
UN-No:
De Minimis - 1170 / 3

(±)18-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid. When formed by the CYP2E1 isoform, 18-HETE is comprised 100% of the (R) isomer.{15766} 18(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, whereas 18(S)-HETE does not affect perfusion pressure.{3825} 18-HETE has negligible effects on ATPase activity.{3825} 18(R)-HETE at 1 µM completely blocks 20-HETE-induced vasoconstriction of renal arterioles.{15772}  

 

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SKU: 10010638 - 100 µg Category:

Description

The racemic version of a CYP450 metabolite of arachidonic acid that dose-dependently stimulates vasodilation of the rabbit kidney

Formal name: (±)18-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid

Synonyms: 

Molecular weight: 320.5

CAS: 133268-58-3

Purity: ≥97%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Hydroxy/Hydroperoxy/ Epoxy/Oxo Eicosanoids||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways

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