A DHA metabolite derived via epoxidation of the 16

(±)16(17)-EpDPA – 50 µg

Brand:
Cayman
CAS:
155073-46-4
Storage:
-20
UN-No:
De Minimis - 1170 / 3

EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.{6485,7204} Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EET (Item No. 50651) which are prime candidates for the actual active mediator.{5826} However, the CYP450 metabolites of eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310) have been little studied relative to arachidonate epoxygenase metabolites. (±)16(17)-EpDPA is the DHA homolog of (±)14(15)-EpETrE, derived via epoxidation of the 16,17-double bond of DHA. The EDHF activity of (±)16(17)-EpDPA has not yet been determined. The epoxygenase metabolites of DHA have also been detected in a mouse inflammation model.{11433}  

 

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SKU: 10174 - 50 µg Category:

Description

A DHA metabolite derived via epoxidation of the 16,17-double bond; epoxygenase metabolites of DHA have been detected in a mouse model of inflammation

Formal name: (±)16,17-epoxy-4Z,7Z,10Z,13Z,19Z-docosapentaenoic acid

Synonyms:  (±)16,17 EDP|(±)16,17-epoxy Docosapentaenoic Acid|(±)16,17-epoxy DPA|(±)16,17-EpDPE

Molecular weight: 344.5

CAS: 155073-46-4

Purity: ≥90%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways||Research Area|Neuroscience

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