The racemic version of a minor CYP450 metabolite of arachidonic acid with stereospecific effects on renal function; 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney while 16(S)-HETE potently inhibits proximal tubule ATPase activity.

(±)16-HETE – 25 µg

Brand:
Cayman
CAS:
128914-46-5
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure.{3825} At a concentration of 2 µM the (S)-enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R)-isomer has negligible effects on ATPase activity.{3825}  

 

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SKU: 10010635 - 25 µg Category:

Description

The racemic version of a minor CYP450 metabolite of arachidonic acid with stereospecific effects on renal function; 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney while 16(S)-HETE potently inhibits proximal tubule ATPase activity.

Formal name: (±)16-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid

Synonyms: 

Molecular weight: 320.5

CAS: 128914-46-5

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Hydroxy/Hydroperoxy/ Epoxy/Oxo Eicosanoids||Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways

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