A DHA epoxygenase metabolite detected in rat brain and spinal cord

(±)10(11)-EpDPA – 25 µg

Brand:
Cayman
CAS:
895127-65-8
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)10(11)-EpDPA is a docosahexaenoic acid (DHA; Item No. 90310) epoxygenase metabolite, derived via epoxidation of the 10,11-double bond of DHA. It has been detected in rat brain and spinal cord, as well as human serum, and acts as a substrate for soluble epoxide hydrolase with a Km value of 5.1 µM.{29509,29508} (±)10(11)-EpDPA and other epoxy metabolites of DHA are reported to demonstrate antihyperalgesic activity in inflammatory and neuropathic pain models and to potently inhibit angiogenesis and tumor growth in in vitro assays.{29509,26641}  

 

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SKU: 10471 - 25 µg Category:

Description

A DHA epoxygenase metabolite detected in rat brain and spinal cord, as well as human serum, that acts as a substrate for sEH (Km = 5.1 µM); demonstrates antihyperalgesic activity in inflammatory and neuropathic pain models and potently inhibits angiogenesis and tumor growth in in vitro assays

Formal name: (±)-(4Z,7Z)-9-[3-(2Z,5Z,8Z)-2,5,8-undecatrien-1-yl-2-oxiranyl]-4,7-nonadienoic acid

Synonyms:  (±)10,11-EDP|(±)10,11-EpDPE|(±)10,11-epoxy Docosapentaenoic Acid|(±)10,11-epoxy DPA

Molecular weight: 344.5

CAS: 895127-65-8

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Cancer|Angiogenesis||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways

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