Cayman
Showing 14101–14250 of 45550 results
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Prostaglandin E2 (PGE2; Item No. 14010) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a G protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis.{16772,16773,16619} CAY10684 is a lactam that acts as a potent EP4 agonist, triggering cAMP signaling with an EC50 value of 0.8 nM.{13508} It displays more than 1,000-fold selectivity for EP4 over other EP receptors.{13508}
Brand:CaymanSKU:- Prostaglandin E2 (PGE2; Item No. 14010) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a G protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis.{16772,16773,16619} CAY10684 is a lactam that acts as a potent EP4 agonist, triggering cAMP signaling with an EC50 value of 0.8 nM.{13508} It displays more than 1,000-fold selectivity for EP4 over other EP receptors.{13508}
Brand:CaymanSKU:- Prostaglandin E2 (PGE2; Item No. 14010) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a G protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis.{16772,16773,16619} CAY10684 is a lactam that acts as a potent EP4 agonist, triggering cAMP signaling with an EC50 value of 0.8 nM.{13508} It displays more than 1,000-fold selectivity for EP4 over other EP receptors.{13508}
Brand:CaymanSKU:-
CAY10685 is a cell-active analog of the lysine acetyltransferase inhibitor CPTH2 (Item No. 12086) that contains an alkyne moiety for use in click chemistry reactions.{26026} Its ability to inhibit N-acetyltransferase 10 activity has been used to modulate chromatin organization in order to study changes in nuclear architecture associated with cancer and certain laminopathies.{26026}
Brand:CaymanSKU:- CAY10685 is a cell-active analog of the lysine acetyltransferase inhibitor CPTH2 (Item No. 12086) that contains an alkyne moiety for use in click chemistry reactions.{26026} Its ability to inhibit N-acetyltransferase 10 activity has been used to modulate chromatin organization in order to study changes in nuclear architecture associated with cancer and certain laminopathies.{26026}
Brand:CaymanSKU:- CAY10685 is a cell-active analog of the lysine acetyltransferase inhibitor CPTH2 (Item No. 12086) that contains an alkyne moiety for use in click chemistry reactions.{26026} Its ability to inhibit N-acetyltransferase 10 activity has been used to modulate chromatin organization in order to study changes in nuclear architecture associated with cancer and certain laminopathies.{26026}
Brand:CaymanSKU:- CAY10685 is a cell-active analog of the lysine acetyltransferase inhibitor CPTH2 (Item No. 12086) that contains an alkyne moiety for use in click chemistry reactions.{26026} Its ability to inhibit N-acetyltransferase 10 activity has been used to modulate chromatin organization in order to study changes in nuclear architecture associated with cancer and certain laminopathies.{26026}
Brand:CaymanSKU:-
Dasatinib (Item No. 11498) is a potent inhibitor of receptor and non-receptor tyrosine kinases, including some drug resistant mutant forms.{24166,24167,24156,24168} It has potential therapeutic value in diseases that are characterized by elevated levels of these kinases, including some forms of cancer and fibrotic disease.{24166,24164,17350,17482} CAY10697 is an intermediate in the synthesis of dasatinib.{28934}
Brand:CaymanSKU:-Available on backorder
Dasatinib (Item No. 11498) is a potent inhibitor of receptor and non-receptor tyrosine kinases, including some drug resistant mutant forms.{24166,24167,24156,24168} It has potential therapeutic value in diseases that are characterized by elevated levels of these kinases, including some forms of cancer and fibrotic disease.{24166,24164,17350,17482} CAY10697 is an intermediate in the synthesis of dasatinib.{28934}
Brand:CaymanSKU:-Available on backorder
Dasatinib (Item No. 11498) is a potent inhibitor of receptor and non-receptor tyrosine kinases, including some drug resistant mutant forms.{24166,24167,24156,24168} It has potential therapeutic value in diseases that are characterized by elevated levels of these kinases, including some forms of cancer and fibrotic disease.{24166,24164,17350,17482} CAY10697 is an intermediate in the synthesis of dasatinib.{28934}
Brand:CaymanSKU:-Available on backorder
Dasatinib (Item No. 11498) is a potent inhibitor of receptor and non-receptor tyrosine kinases, including some drug resistant mutant forms.{24166,24167,24156,24168} It has potential therapeutic value in diseases that are characterized by elevated levels of these kinases, including some forms of cancer and fibrotic disease.{24166,24164,17350,17482} CAY10697 is an intermediate in the synthesis of dasatinib.{28934}
Brand:CaymanSKU:-Available on backorder
Platelet-type 12-lipoxygenase (12-LO; Item No. 10341) catalyzes the formation of 12-HpETE (Item No. 44570) from arachidonic acid (Item No. 90010).{3606} It has been found to be expressed in various tumor cells as well as pancreatic islets and can be activated by inflammatory cytokines.{25127} It has also been implicated in the modulation of hemostasis and thrombosis through its role in regulating platelet function.{25127} CAY10698 is an inhibitor of 12-LO with an IC50 value of 5.1 µM. It demonstrates greatly reduced potency for 15-LO-1, 15-LO-2, and 5-LO (IC50s = >50, >40, and >200 µM.{25127} The scaffold of this compound has been subjected to medicinal chemistry optimization and biological characterization for development of potential 12-LO inhibitors.{25127}
Brand:CaymanSKU:-Available on backorder
Platelet-type 12-lipoxygenase (12-LO; Item No. 10341) catalyzes the formation of 12-HpETE (Item No. 44570) from arachidonic acid (Item No. 90010).{3606} It has been found to be expressed in various tumor cells as well as pancreatic islets and can be activated by inflammatory cytokines.{25127} It has also been implicated in the modulation of hemostasis and thrombosis through its role in regulating platelet function.{25127} CAY10698 is an inhibitor of 12-LO with an IC50 value of 5.1 µM. It demonstrates greatly reduced potency for 15-LO-1, 15-LO-2, and 5-LO (IC50s = >50, >40, and >200 µM.{25127} The scaffold of this compound has been subjected to medicinal chemistry optimization and biological characterization for development of potential 12-LO inhibitors.{25127}
Brand:CaymanSKU:-Available on backorder
Platelet-type 12-lipoxygenase (12-LO; Item No. 10341) catalyzes the formation of 12-HpETE (Item No. 44570) from arachidonic acid (Item No. 90010).{3606} It has been found to be expressed in various tumor cells as well as pancreatic islets and can be activated by inflammatory cytokines.{25127} It has also been implicated in the modulation of hemostasis and thrombosis through its role in regulating platelet function.{25127} CAY10698 is an inhibitor of 12-LO with an IC50 value of 5.1 µM. It demonstrates greatly reduced potency for 15-LO-1, 15-LO-2, and 5-LO (IC50s = >50, >40, and >200 µM.{25127} The scaffold of this compound has been subjected to medicinal chemistry optimization and biological characterization for development of potential 12-LO inhibitors.{25127}
Brand:CaymanSKU:-Available on backorder
Platelet-type 12-lipoxygenase (12-LO; Item No. 10341) catalyzes the formation of 12-HpETE (Item No. 44570) from arachidonic acid (Item No. 90010).{3606} It has been found to be expressed in various tumor cells as well as pancreatic islets and can be activated by inflammatory cytokines.{25127} It has also been implicated in the modulation of hemostasis and thrombosis through its role in regulating platelet function.{25127} CAY10698 is an inhibitor of 12-LO with an IC50 value of 5.1 µM. It demonstrates greatly reduced potency for 15-LO-1, 15-LO-2, and 5-LO (IC50s = >50, >40, and >200 µM.{25127} The scaffold of this compound has been subjected to medicinal chemistry optimization and biological characterization for development of potential 12-LO inhibitors.{25127}
Brand:CaymanSKU:-Available on backorder
Prostaglandin E2 (PGE2; Item No. 14010) is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases. It acts as a mediator of pain and inflammation and promotes bone destruction. The increased synthesis of PGE2 during inflammation can be accounted for by increased expression of both COX-2 and microsomal PGE synthase-1 (mPGES-1). CAY10700 is an orally bioavailable inhibitor of mPGES-1 (IC50 = 0.24 µM in an in vitro human whole blood assay).{30657} It is inactive against COX-1 and COX-2 (9% inhibition at 100 µM and 16% at 30 µM, respectively).{30657}
Brand:CaymanSKU:-Available on backorder
Prostaglandin E2 (PGE2; Item No. 14010) is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases. It acts as a mediator of pain and inflammation and promotes bone destruction. The increased synthesis of PGE2 during inflammation can be accounted for by increased expression of both COX-2 and microsomal PGE synthase-1 (mPGES-1). CAY10700 is an orally bioavailable inhibitor of mPGES-1 (IC50 = 0.24 µM in an in vitro human whole blood assay).{30657} It is inactive against COX-1 and COX-2 (9% inhibition at 100 µM and 16% at 30 µM, respectively).{30657}
Brand:CaymanSKU:-Available on backorder
Prostaglandin E2 (PGE2; Item No. 14010) is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases. It acts as a mediator of pain and inflammation and promotes bone destruction. The increased synthesis of PGE2 during inflammation can be accounted for by increased expression of both COX-2 and microsomal PGE synthase-1 (mPGES-1). CAY10700 is an orally bioavailable inhibitor of mPGES-1 (IC50 = 0.24 µM in an in vitro human whole blood assay).{30657} It is inactive against COX-1 and COX-2 (9% inhibition at 100 µM and 16% at 30 µM, respectively).{30657}
Brand:CaymanSKU:-Available on backorder
CAY10701 is a 7-deazahypoxanthine analog that prevents microtubule formation, blocking the proliferation of HeLa and MCF-7 cells (GI50s = 22 and 38 nM, respectively).{32584} It also inhibits the growth of several different colorectal cancer cell lines (GI50 values range from 9 to 17 nM), while being at least 1,500-fold less effective against normal human fibroblast WI38 cells.{32584} CAY10701 is effective in vivo, reducing tumor volume in colorectal cell xenografts in mice without significantly altering body weight.{32584}
Brand:CaymanSKU:-Available on backorder
CAY10701 is a 7-deazahypoxanthine analog that prevents microtubule formation, blocking the proliferation of HeLa and MCF-7 cells (GI50s = 22 and 38 nM, respectively).{32584} It also inhibits the growth of several different colorectal cancer cell lines (GI50 values range from 9 to 17 nM), while being at least 1,500-fold less effective against normal human fibroblast WI38 cells.{32584} CAY10701 is effective in vivo, reducing tumor volume in colorectal cell xenografts in mice without significantly altering body weight.{32584}
Brand:CaymanSKU:-Available on backorder
CAY10701 is a 7-deazahypoxanthine analog that prevents microtubule formation, blocking the proliferation of HeLa and MCF-7 cells (GI50s = 22 and 38 nM, respectively).{32584} It also inhibits the growth of several different colorectal cancer cell lines (GI50 values range from 9 to 17 nM), while being at least 1,500-fold less effective against normal human fibroblast WI38 cells.{32584} CAY10701 is effective in vivo, reducing tumor volume in colorectal cell xenografts in mice without significantly altering body weight.{32584}
Brand:CaymanSKU:-Available on backorder
Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria.{30579,30576} Inhibition of PDHK shifts cell metabolism from glycolysis to mitochondrial glucose oxidation, an effect that has relevance to cancer, type 2 diabetes, and other diseases.{30576,30577} CAY10703 is a DCA trimer that is at least 10-fold more cytotoxic against leukemia cell lines than DCA.{30578} It is approximately 3-fold less cytotoxic than DCA against peripheral blood mononuclear cells from healthy blood donors. CAY10703 significantly reduces both basal and maximal respiration in leukemia cells.{30578} It is stable in vivo after subcutaneous inoculation, remaining in circulation for more than five hours after injection.{30578}
Brand:CaymanSKU:-Available on backorder
Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria.{30579,30576} Inhibition of PDHK shifts cell metabolism from glycolysis to mitochondrial glucose oxidation, an effect that has relevance to cancer, type 2 diabetes, and other diseases.{30576,30577} CAY10703 is a DCA trimer that is at least 10-fold more cytotoxic against leukemia cell lines than DCA.{30578} It is approximately 3-fold less cytotoxic than DCA against peripheral blood mononuclear cells from healthy blood donors. CAY10703 significantly reduces both basal and maximal respiration in leukemia cells.{30578} It is stable in vivo after subcutaneous inoculation, remaining in circulation for more than five hours after injection.{30578}
Brand:CaymanSKU:-Available on backorder
Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria.{30579,30576} Inhibition of PDHK shifts cell metabolism from glycolysis to mitochondrial glucose oxidation, an effect that has relevance to cancer, type 2 diabetes, and other diseases.{30576,30577} CAY10703 is a DCA trimer that is at least 10-fold more cytotoxic against leukemia cell lines than DCA.{30578} It is approximately 3-fold less cytotoxic than DCA against peripheral blood mononuclear cells from healthy blood donors. CAY10703 significantly reduces both basal and maximal respiration in leukemia cells.{30578} It is stable in vivo after subcutaneous inoculation, remaining in circulation for more than five hours after injection.{30578}
Brand:CaymanSKU:-Available on backorder
Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria.{30579,30576} Inhibition of PDHK shifts cell metabolism from glycolysis to mitochondrial glucose oxidation, an effect that has relevance to cancer, type 2 diabetes, and other diseases.{30576,30577} CAY10703 is a DCA trimer that is at least 10-fold more cytotoxic against leukemia cell lines than DCA.{30578} It is approximately 3-fold less cytotoxic than DCA against peripheral blood mononuclear cells from healthy blood donors. CAY10703 significantly reduces both basal and maximal respiration in leukemia cells.{30578} It is stable in vivo after subcutaneous inoculation, remaining in circulation for more than five hours after injection.{30578}
Brand:CaymanSKU:-Available on backorder
CAY10704 is a potent inhibitor of hepatitis C virus (HCV) infection (EC50 = 17 nM) that displays low cytotoxicity of virally-infected human hepatoma Huh7.5.1 cells (CC50 = 21.3 µM).{30619} It displays good pharmacokinetics in mice when delivered intraperitoneally, with preferential liver distribution without significant hepatotoxicity.{30619} CAY10704 is selective for HCV over dengue virus (EC50 = 4.62 µM).{30619}
Brand:CaymanSKU:-Available on backorder
CAY10704 is a potent inhibitor of hepatitis C virus (HCV) infection (EC50 = 17 nM) that displays low cytotoxicity of virally-infected human hepatoma Huh7.5.1 cells (CC50 = 21.3 µM).{30619} It displays good pharmacokinetics in mice when delivered intraperitoneally, with preferential liver distribution without significant hepatotoxicity.{30619} CAY10704 is selective for HCV over dengue virus (EC50 = 4.62 µM).{30619}
Brand:CaymanSKU:-Available on backorder
CAY10704 is a potent inhibitor of hepatitis C virus (HCV) infection (EC50 = 17 nM) that displays low cytotoxicity of virally-infected human hepatoma Huh7.5.1 cells (CC50 = 21.3 µM).{30619} It displays good pharmacokinetics in mice when delivered intraperitoneally, with preferential liver distribution without significant hepatotoxicity.{30619} CAY10704 is selective for HCV over dengue virus (EC50 = 4.62 µM).{30619}
Brand:CaymanSKU:-Available on backorder
CAY10711 is a substituted diamine that produces rapid bactericidal activity against both Gram-positive and Gram-negative bacteria, including methicillin-resistant S. aureus (MRSA) and stationary-phase bacteria.{31010} It displays MIC99 values of 2.9, 11.5, 2.9, and 2.9 µM against S. aureus RN4220, P. aeruginosa PAO1, E. coli ANS1, and MRSA 10082B, respectively.{31010} CAY10711 reduces biofilm formation and promotes biofilm dispersal in P. aeruginosa. It is synergistic with kanamycin and has limited adverse effects against mammalian cells or C. elegans development, survival, or reproduction.{31010}
Brand:CaymanSKU:-Available on backorder
CAY10711 is a substituted diamine that produces rapid bactericidal activity against both Gram-positive and Gram-negative bacteria, including methicillin-resistant S. aureus (MRSA) and stationary-phase bacteria.{31010} It displays MIC99 values of 2.9, 11.5, 2.9, and 2.9 µM against S. aureus RN4220, P. aeruginosa PAO1, E. coli ANS1, and MRSA 10082B, respectively.{31010} CAY10711 reduces biofilm formation and promotes biofilm dispersal in P. aeruginosa. It is synergistic with kanamycin and has limited adverse effects against mammalian cells or C. elegans development, survival, or reproduction.{31010}
Brand:CaymanSKU:-Available on backorder
CAY10711 is a substituted diamine that produces rapid bactericidal activity against both Gram-positive and Gram-negative bacteria, including methicillin-resistant S. aureus (MRSA) and stationary-phase bacteria.{31010} It displays MIC99 values of 2.9, 11.5, 2.9, and 2.9 µM against S. aureus RN4220, P. aeruginosa PAO1, E. coli ANS1, and MRSA 10082B, respectively.{31010} CAY10711 reduces biofilm formation and promotes biofilm dispersal in P. aeruginosa. It is synergistic with kanamycin and has limited adverse effects against mammalian cells or C. elegans development, survival, or reproduction.{31010}
Brand:CaymanSKU:-Available on backorder
CAY10711 is a substituted diamine that produces rapid bactericidal activity against both Gram-positive and Gram-negative bacteria, including methicillin-resistant S. aureus (MRSA) and stationary-phase bacteria.{31010} It displays MIC99 values of 2.9, 11.5, 2.9, and 2.9 µM against S. aureus RN4220, P. aeruginosa PAO1, E. coli ANS1, and MRSA 10082B, respectively.{31010} CAY10711 reduces biofilm formation and promotes biofilm dispersal in P. aeruginosa. It is synergistic with kanamycin and has limited adverse effects against mammalian cells or C. elegans development, survival, or reproduction.{31010}
Brand:CaymanSKU:-Available on backorder
CAY10717 is a multi-targeted kinase inhibitor that exhibits greater than 40% inhibition of 34 of 104 kinases in an enzymatic assay at a concentration of 100 nM.{31601} It has activity at multiple oncogenic kinases, with IC50 values less than 50 nM against wild-type EGFR and ABL and mutant ABLG250E, ABLY253F, ABLE255K, and B-RafV600E. CAY10717 is highly cytotoxic against a cancer cell panel that includes chemotherapy-sensitive and -resistant cell lines (EC50s = 0.4-158 nM). It also inhibits the growth of human umbilical vein endothelial cells (HUVECs; EC50 = 34 nM), a model for tumor angiogenesis.
Brand:CaymanSKU:19955 -Available on backorder
CAY10717 is a multi-targeted kinase inhibitor that exhibits greater than 40% inhibition of 34 of 104 kinases in an enzymatic assay at a concentration of 100 nM.{31601} It has activity at multiple oncogenic kinases, with IC50 values less than 50 nM against wild-type EGFR and ABL and mutant ABLG250E, ABLY253F, ABLE255K, and B-RafV600E. CAY10717 is highly cytotoxic against a cancer cell panel that includes chemotherapy-sensitive and -resistant cell lines (EC50s = 0.4-158 nM). It also inhibits the growth of human umbilical vein endothelial cells (HUVECs; EC50 = 34 nM), a model for tumor angiogenesis.
Brand:CaymanSKU:19955 -Available on backorder
CAY10717 is a multi-targeted kinase inhibitor that exhibits greater than 40% inhibition of 34 of 104 kinases in an enzymatic assay at a concentration of 100 nM.{31601} It has activity at multiple oncogenic kinases, with IC50 values less than 50 nM against wild-type EGFR and ABL and mutant ABLG250E, ABLY253F, ABLE255K, and B-RafV600E. CAY10717 is highly cytotoxic against a cancer cell panel that includes chemotherapy-sensitive and -resistant cell lines (EC50s = 0.4-158 nM). It also inhibits the growth of human umbilical vein endothelial cells (HUVECs; EC50 = 34 nM), a model for tumor angiogenesis.
Brand:CaymanSKU:19955 -Available on backorder
CAY10717 is a multi-targeted kinase inhibitor that exhibits greater than 40% inhibition of 34 of 104 kinases in an enzymatic assay at a concentration of 100 nM.{31601} It has activity at multiple oncogenic kinases, with IC50 values less than 50 nM against wild-type EGFR and ABL and mutant ABLG250E, ABLY253F, ABLE255K, and B-RafV600E. CAY10717 is highly cytotoxic against a cancer cell panel that includes chemotherapy-sensitive and -resistant cell lines (EC50s = 0.4-158 nM). It also inhibits the growth of human umbilical vein endothelial cells (HUVECs; EC50 = 34 nM), a model for tumor angiogenesis.
Brand:CaymanSKU:19955 -Available on backorder
CAY10719 is a selective inhibitor of the breast cancer resistance protein ABCG2 (IC50 = 0.23 µM) with little activity at ABCG1.{32026} It has been shown to reverse the ABCG2-mediated resistance toward SN 38 (Item No. 15632) and to inhibit ATPase activity.{32026}
Brand:CaymanSKU:20469 -Available on backorder
CAY10719 is a selective inhibitor of the breast cancer resistance protein ABCG2 (IC50 = 0.23 µM) with little activity at ABCG1.{32026} It has been shown to reverse the ABCG2-mediated resistance toward SN 38 (Item No. 15632) and to inhibit ATPase activity.{32026}
Brand:CaymanSKU:20469 -Available on backorder
CAY10719 is a selective inhibitor of the breast cancer resistance protein ABCG2 (IC50 = 0.23 µM) with little activity at ABCG1.{32026} It has been shown to reverse the ABCG2-mediated resistance toward SN 38 (Item No. 15632) and to inhibit ATPase activity.{32026}
Brand:CaymanSKU:20469 -Available on backorder
CAY10719 is a selective inhibitor of the breast cancer resistance protein ABCG2 (IC50 = 0.23 µM) with little activity at ABCG1.{32026} It has been shown to reverse the ABCG2-mediated resistance toward SN 38 (Item No. 15632) and to inhibit ATPase activity.{32026}
Brand:CaymanSKU:20469 -Available on backorder
CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 μM).{36009} Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph node involvement, while SIRT3 down-regulation inhibits the growth of OSCC cells and sensitizes them to radiation and chemotherapy.{36009,36010,36011}
Brand:CaymanSKU:22403 -Out of stock
CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 μM).{36009} Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph node involvement, while SIRT3 down-regulation inhibits the growth of OSCC cells and sensitizes them to radiation and chemotherapy.{36009,36010,36011}
Brand:CaymanSKU:22403 -Out of stock
CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 μM).{36009} Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph node involvement, while SIRT3 down-regulation inhibits the growth of OSCC cells and sensitizes them to radiation and chemotherapy.{36009,36010,36011}
Brand:CaymanSKU:22403 -Out of stock
CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 μM).{36009} Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph node involvement, while SIRT3 down-regulation inhibits the growth of OSCC cells and sensitizes them to radiation and chemotherapy.{36009,36010,36011}
Brand:CaymanSKU:22403 -Out of stock
CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 µM).{39002} SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type.{39000,39003} High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load.{39004} In contrast, low SIRT3 expression in patient-derived breast cancer cells is correlated with shorter survival.{39001}
Brand:CaymanSKU:22404 -Out of stock
CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 µM).{39002} SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type.{39000,39003} High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load.{39004} In contrast, low SIRT3 expression in patient-derived breast cancer cells is correlated with shorter survival.{39001}
Brand:CaymanSKU:22404 -Out of stock
CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 µM).{39002} SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type.{39000,39003} High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load.{39004} In contrast, low SIRT3 expression in patient-derived breast cancer cells is correlated with shorter survival.{39001}
Brand:CaymanSKU:22404 -Out of stock
CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 µM).{39002} SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type.{39000,39003} High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load.{39004} In contrast, low SIRT3 expression in patient-derived breast cancer cells is correlated with shorter survival.{39001}
Brand:CaymanSKU:22404 -Out of stock
CAY10723 is an inhibitor of protein arginine deiminase 2 (PAD2) that binds to PAD2 in a target engagement assay (EC50 = 9.5 μM in HEK293/PAD2 cells).{36047} It is 1.6-, 47-, and ~15-fold selective for PAD2 over PAD1, PAD3, and PAD4, respectively. CAY10723 inhibits histone H3 citrullination in HEK293/PAD2 cells (EC50 = 0.4 μM).
Brand:CaymanSKU:22653 -Out of stock
CAY10723 is an inhibitor of protein arginine deiminase 2 (PAD2) that binds to PAD2 in a target engagement assay (EC50 = 9.5 μM in HEK293/PAD2 cells).{36047} It is 1.6-, 47-, and ~15-fold selective for PAD2 over PAD1, PAD3, and PAD4, respectively. CAY10723 inhibits histone H3 citrullination in HEK293/PAD2 cells (EC50 = 0.4 μM).
Brand:CaymanSKU:22653 -Out of stock
CAY10723 is an inhibitor of protein arginine deiminase 2 (PAD2) that binds to PAD2 in a target engagement assay (EC50 = 9.5 μM in HEK293/PAD2 cells).{36047} It is 1.6-, 47-, and ~15-fold selective for PAD2 over PAD1, PAD3, and PAD4, respectively. CAY10723 inhibits histone H3 citrullination in HEK293/PAD2 cells (EC50 = 0.4 μM).
Brand:CaymanSKU:22653 -Out of stock
CAY10726 is an arylurea fatty acid.{40512} It decreases ATP production by 28% in MDA-MB-231 breast cancer cells when used at a concentration of 10 μM. CAY10726 decreases proliferation and initiates apoptosis in MDA-MB-231 cells via depletion of the phospholipid cardiolipin and its precursor phosphatidylglycerol from the mitochondrial membrane. In vivo, CAY10726 (2.5-40 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a mouse MDA-MB-231 breast cancer xenograft model in a dose-dependent manner.
Brand:CaymanSKU:23859 - 1 mgAvailable on backorder
CAY10726 is an arylurea fatty acid.{40512} It decreases ATP production by 28% in MDA-MB-231 breast cancer cells when used at a concentration of 10 μM. CAY10726 decreases proliferation and initiates apoptosis in MDA-MB-231 cells via depletion of the phospholipid cardiolipin and its precursor phosphatidylglycerol from the mitochondrial membrane. In vivo, CAY10726 (2.5-40 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a mouse MDA-MB-231 breast cancer xenograft model in a dose-dependent manner.
Brand:CaymanSKU:23859 - 10 mgAvailable on backorder
CAY10726 is an arylurea fatty acid.{40512} It decreases ATP production by 28% in MDA-MB-231 breast cancer cells when used at a concentration of 10 μM. CAY10726 decreases proliferation and initiates apoptosis in MDA-MB-231 cells via depletion of the phospholipid cardiolipin and its precursor phosphatidylglycerol from the mitochondrial membrane. In vivo, CAY10726 (2.5-40 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a mouse MDA-MB-231 breast cancer xenograft model in a dose-dependent manner.
Brand:CaymanSKU:23859 - 25 mgAvailable on backorder
CAY10726 is an arylurea fatty acid.{40512} It decreases ATP production by 28% in MDA-MB-231 breast cancer cells when used at a concentration of 10 μM. CAY10726 decreases proliferation and initiates apoptosis in MDA-MB-231 cells via depletion of the phospholipid cardiolipin and its precursor phosphatidylglycerol from the mitochondrial membrane. In vivo, CAY10726 (2.5-40 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a mouse MDA-MB-231 breast cancer xenograft model in a dose-dependent manner.
Brand:CaymanSKU:23859 - 5 mgAvailable on backorder
CAY10727 is an inhibitor of protein arginine deiminase 3 (PAD3; kinact/KI = 15,600 M-1min-1).{48907} It is selective for PAD3 over PAD1, -2, and -4 (kinact/KIs = 360, 1,110, and 1,460 M-1min-1, respectively).
Brand:CaymanSKU:26543 - 1 mgAvailable on backorder
CAY10727 is an inhibitor of protein arginine deiminase 3 (PAD3; kinact/KI = 15,600 M-1min-1).{48907} It is selective for PAD3 over PAD1, -2, and -4 (kinact/KIs = 360, 1,110, and 1,460 M-1min-1, respectively).
Brand:CaymanSKU:26543 - 100 µgAvailable on backorder
CAY10727 is an inhibitor of protein arginine deiminase 3 (PAD3; kinact/KI = 15,600 M-1min-1).{48907} It is selective for PAD3 over PAD1, -2, and -4 (kinact/KIs = 360, 1,110, and 1,460 M-1min-1, respectively).
Brand:CaymanSKU:26543 - 250 µgAvailable on backorder
CAY10727 is an inhibitor of protein arginine deiminase 3 (PAD3; kinact/KI = 15,600 M-1min-1).{48907} It is selective for PAD3 over PAD1, -2, and -4 (kinact/KIs = 360, 1,110, and 1,460 M-1min-1, respectively).
Brand:CaymanSKU:26543 - 500 µgAvailable on backorder
CAY10730 is a turn-on fluorescent probe for the detection of nitroreductase activity, a marker of hypoxia.{48243} In the presence of nitroreductase, CAY10730 is transformed into a highly fluorescent molecule that displays excitation/emission maxima of 454/520 nm, respectively. It is selective for nitroreductase over a variety of bioanalytes, including glutathione, ascorbic acid, and reactive oxygen species such as H2O2. CAY10730 (1 µM) has been used to detect hypoxia in A549 human lung carcinoma cells.
Brand:CaymanSKU:26547 - 10 mgAvailable on backorder
CAY10730 is a turn-on fluorescent probe for the detection of nitroreductase activity, a marker of hypoxia.{48243} In the presence of nitroreductase, CAY10730 is transformed into a highly fluorescent molecule that displays excitation/emission maxima of 454/520 nm, respectively. It is selective for nitroreductase over a variety of bioanalytes, including glutathione, ascorbic acid, and reactive oxygen species such as H2O2. CAY10730 (1 µM) has been used to detect hypoxia in A549 human lung carcinoma cells.
Brand:CaymanSKU:26547 - 25 mgAvailable on backorder
CAY10730 is a turn-on fluorescent probe for the detection of nitroreductase activity, a marker of hypoxia.{48243} In the presence of nitroreductase, CAY10730 is transformed into a highly fluorescent molecule that displays excitation/emission maxima of 454/520 nm, respectively. It is selective for nitroreductase over a variety of bioanalytes, including glutathione, ascorbic acid, and reactive oxygen species such as H2O2. CAY10730 (1 µM) has been used to detect hypoxia in A549 human lung carcinoma cells.
Brand:CaymanSKU:26547 - 5 mgAvailable on backorder
CAY10730 is a turn-on fluorescent probe for the detection of nitroreductase activity, a marker of hypoxia.{48243} In the presence of nitroreductase, CAY10730 is transformed into a highly fluorescent molecule that displays excitation/emission maxima of 454/520 nm, respectively. It is selective for nitroreductase over a variety of bioanalytes, including glutathione, ascorbic acid, and reactive oxygen species such as H2O2. CAY10730 (1 µM) has been used to detect hypoxia in A549 human lung carcinoma cells.
Brand:CaymanSKU:26547 - 50 mgAvailable on backorder
CAY10731 is a fluorescent probe for hydrogen sulfide (H2S).{48317} Upon reaction with H2S, fluorescein (FITC) is released and its fluorescence can be used to detect H2S. FITC displays excitation/emission maxima of 485/535 nm, respectively. CAY10731 is selective for H2S over glutathione (GSH), cysteine, H2O3-, SO3-, and H2O2 as well as tBuO and OH radicals. It has been used to detect H2S in rat hippocampal slices and nematodes.
Brand:CaymanSKU:26548 - 1 mgAvailable on backorder
CAY10731 is a fluorescent probe for hydrogen sulfide (H2S).{48317} Upon reaction with H2S, fluorescein (FITC) is released and its fluorescence can be used to detect H2S. FITC displays excitation/emission maxima of 485/535 nm, respectively. CAY10731 is selective for H2S over glutathione (GSH), cysteine, H2O3-, SO3-, and H2O2 as well as tBuO and OH radicals. It has been used to detect H2S in rat hippocampal slices and nematodes.
Brand:CaymanSKU:26548 - 10 mgAvailable on backorder
CAY10731 is a fluorescent probe for hydrogen sulfide (H2S).{48317} Upon reaction with H2S, fluorescein (FITC) is released and its fluorescence can be used to detect H2S. FITC displays excitation/emission maxima of 485/535 nm, respectively. CAY10731 is selective for H2S over glutathione (GSH), cysteine, H2O3-, SO3-, and H2O2 as well as tBuO and OH radicals. It has been used to detect H2S in rat hippocampal slices and nematodes.
Brand:CaymanSKU:26548 - 25 mgAvailable on backorder
CAY10731 is a fluorescent probe for hydrogen sulfide (H2S).{48317} Upon reaction with H2S, fluorescein (FITC) is released and its fluorescence can be used to detect H2S. FITC displays excitation/emission maxima of 485/535 nm, respectively. CAY10731 is selective for H2S over glutathione (GSH), cysteine, H2O3-, SO3-, and H2O2 as well as tBuO and OH radicals. It has been used to detect H2S in rat hippocampal slices and nematodes.
Brand:CaymanSKU:26548 - 5 mgAvailable on backorder
CAY10732 is a fluorescent probe for the detection of carbon monoxide.{49090} In the presence of palladium (Pd) and carbon monoxide, CAY10732 undergoes the Pd0-mediated Tsuji-Trost reaction to release 2,7-dichlorofluorescein, and its fluorescence can be used to detect carbon monoxide production in vitro and in live cells. 2,7-Dichlorofluorescein displays excitation/emission maxima of 493/527 nm, respectively.
Brand:CaymanSKU:26750 - 1 mgAvailable on backorder
CAY10732 is a fluorescent probe for the detection of carbon monoxide.{49090} In the presence of palladium (Pd) and carbon monoxide, CAY10732 undergoes the Pd0-mediated Tsuji-Trost reaction to release 2,7-dichlorofluorescein, and its fluorescence can be used to detect carbon monoxide production in vitro and in live cells. 2,7-Dichlorofluorescein displays excitation/emission maxima of 493/527 nm, respectively.
Brand:CaymanSKU:26750 - 10 mgAvailable on backorder
CAY10732 is a fluorescent probe for the detection of carbon monoxide.{49090} In the presence of palladium (Pd) and carbon monoxide, CAY10732 undergoes the Pd0-mediated Tsuji-Trost reaction to release 2,7-dichlorofluorescein, and its fluorescence can be used to detect carbon monoxide production in vitro and in live cells. 2,7-Dichlorofluorescein displays excitation/emission maxima of 493/527 nm, respectively.
Brand:CaymanSKU:26750 - 5 mgAvailable on backorder
CAY10732 is a fluorescent probe for the detection of carbon monoxide.{49090} In the presence of palladium (Pd) and carbon monoxide, CAY10732 undergoes the Pd0-mediated Tsuji-Trost reaction to release 2,7-dichlorofluorescein, and its fluorescence can be used to detect carbon monoxide production in vitro and in live cells. 2,7-Dichlorofluorescein displays excitation/emission maxima of 493/527 nm, respectively.
Brand:CaymanSKU:26750 - 50 mgAvailable on backorder
CAY10733 is a fluorescent probe for the detection of carbon monoxide.{49090} In the presence of palladium (Pd) and carbon monoxide, CAY10733 undergoes the Pd0-mediated Tsuji-Trost reaction to release 2,7-dichlorofluorescein, and its fluorescence can be used to detect carbon monoxide production in vitro and in live cells. 2,7-Dichlorofluorescein displays excitation/emission maxima of 493/527 nm, respectively.
Brand:CaymanSKU:26751 - 1 mgAvailable on backorder
CAY10733 is a fluorescent probe for the detection of carbon monoxide.{49090} In the presence of palladium (Pd) and carbon monoxide, CAY10733 undergoes the Pd0-mediated Tsuji-Trost reaction to release 2,7-dichlorofluorescein, and its fluorescence can be used to detect carbon monoxide production in vitro and in live cells. 2,7-Dichlorofluorescein displays excitation/emission maxima of 493/527 nm, respectively.
Brand:CaymanSKU:26751 - 10 mgAvailable on backorder
CAY10733 is a fluorescent probe for the detection of carbon monoxide.{49090} In the presence of palladium (Pd) and carbon monoxide, CAY10733 undergoes the Pd0-mediated Tsuji-Trost reaction to release 2,7-dichlorofluorescein, and its fluorescence can be used to detect carbon monoxide production in vitro and in live cells. 2,7-Dichlorofluorescein displays excitation/emission maxima of 493/527 nm, respectively.
Brand:CaymanSKU:26751 - 5 mgAvailable on backorder
CAY10733 is a fluorescent probe for the detection of carbon monoxide.{49090} In the presence of palladium (Pd) and carbon monoxide, CAY10733 undergoes the Pd0-mediated Tsuji-Trost reaction to release 2,7-dichlorofluorescein, and its fluorescence can be used to detect carbon monoxide production in vitro and in live cells. 2,7-Dichlorofluorescein displays excitation/emission maxima of 493/527 nm, respectively.
Brand:CaymanSKU:26751 - 50 mgAvailable on backorder
CAY10734 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1; IC50 = 0.6 nM).{13377} It selectively binds S1P1 over S1P2, S1P3, and S1P4 receptors (IC50s = >10,000, 12,000, and 70 nM, respectively) but does also bind S1P5 receptors (IC50 = 1 nM) in radioligand binding assays. CAY10734 reduces the number of peripheral blood lymphocytes in mice, rats, and dogs, with the maximal response achieved when administered at doses of 10, 0.5, and 0.5 mg/kg, respectively. It increases graft survival in a rat skin allograft model when administered at a dose of 5 mg/kg per day in combination with cyclosporin A (CsA; Item No. 12088).
Brand:CaymanSKU:10007833 - 1 mgAvailable on backorder
CAY10734 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1; IC50 = 0.6 nM).{13377} It selectively binds S1P1 over S1P2, S1P3, and S1P4 receptors (IC50s = >10,000, 12,000, and 70 nM, respectively) but does also bind S1P5 receptors (IC50 = 1 nM) in radioligand binding assays. CAY10734 reduces the number of peripheral blood lymphocytes in mice, rats, and dogs, with the maximal response achieved when administered at doses of 10, 0.5, and 0.5 mg/kg, respectively. It increases graft survival in a rat skin allograft model when administered at a dose of 5 mg/kg per day in combination with cyclosporin A (CsA; Item No. 12088).
Brand:CaymanSKU:10007833 - 10 mgAvailable on backorder
CAY10734 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1; IC50 = 0.6 nM).{13377} It selectively binds S1P1 over S1P2, S1P3, and S1P4 receptors (IC50s = >10,000, 12,000, and 70 nM, respectively) but does also bind S1P5 receptors (IC50 = 1 nM) in radioligand binding assays. CAY10734 reduces the number of peripheral blood lymphocytes in mice, rats, and dogs, with the maximal response achieved when administered at doses of 10, 0.5, and 0.5 mg/kg, respectively. It increases graft survival in a rat skin allograft model when administered at a dose of 5 mg/kg per day in combination with cyclosporin A (CsA; Item No. 12088).
Brand:CaymanSKU:10007833 - 25 mgAvailable on backorder
CAY10734 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1; IC50 = 0.6 nM).{13377} It selectively binds S1P1 over S1P2, S1P3, and S1P4 receptors (IC50s = >10,000, 12,000, and 70 nM, respectively) but does also bind S1P5 receptors (IC50 = 1 nM) in radioligand binding assays. CAY10734 reduces the number of peripheral blood lymphocytes in mice, rats, and dogs, with the maximal response achieved when administered at doses of 10, 0.5, and 0.5 mg/kg, respectively. It increases graft survival in a rat skin allograft model when administered at a dose of 5 mg/kg per day in combination with cyclosporin A (CsA; Item No. 12088).
Brand:CaymanSKU:10007833 - 5 mgAvailable on backorder
CAY10735 is an anticancer compound.{48452} It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.674-11.56 μM). CAY10735 inhibits migration of and the epithelial-to-mesenchymal transition (EMT) in A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 3.04 and 1.24 μM, respectively) and increases production of reactive oxygen species (ROS) in these cells in a concentration-dependent manner. CAY10735 (5 mg/kg) reduces tumor growth in B16/F10 melanoma and Lewis lung carcinoma mouse models and an A375 mouse xenograft model.
Brand:CaymanSKU:26753 - 1 mgAvailable on backorder
CAY10735 is an anticancer compound.{48452} It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.674-11.56 μM). CAY10735 inhibits migration of and the epithelial-to-mesenchymal transition (EMT) in A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 3.04 and 1.24 μM, respectively) and increases production of reactive oxygen species (ROS) in these cells in a concentration-dependent manner. CAY10735 (5 mg/kg) reduces tumor growth in B16/F10 melanoma and Lewis lung carcinoma mouse models and an A375 mouse xenograft model.
Brand:CaymanSKU:26753 - 10 mgAvailable on backorder