Cayman

Showing 13351–13500 of 45550 results

  • CALXCHOL is a calixarene detergent that can be used to solubilize and stabilize membrane proteins.  

     

    Brand:
    Cayman
    SKU:24783 - 10 mg

    Available on backorder

  • CALXCHOL is a calixarene detergent that can be used to solubilize and stabilize membrane proteins.  

     

    Brand:
    Cayman
    SKU:24783 - 50 mg

    Available on backorder

  • CALXGLUK is a calixarene detergent that can be used to solubilize membrane proteins.{41704} It has a critical micelle concentration (CMC) of 0.025 mM. CALXGLUK has been used to solubilize a membrane GPCR (MP-A) and a membrane transporter (MP-B) from yeast alone and in combination with Triton X-100 (Item No. 600217) and digitonin (Item No. 14952).  

     

    Brand:
    Cayman
    SKU:24784 - 10 mg

    Available on backorder

  • CALXGLUK is a calixarene detergent that can be used to solubilize membrane proteins.{41704} It has a critical micelle concentration (CMC) of 0.025 mM. CALXGLUK has been used to solubilize a membrane GPCR (MP-A) and a membrane transporter (MP-B) from yeast alone and in combination with Triton X-100 (Item No. 600217) and digitonin (Item No. 14952).  

     

    Brand:
    Cayman
    SKU:24784 - 100 mg

    Available on backorder

  • CALXGLUK is a calixarene detergent that can be used to solubilize membrane proteins.{41704} It has a critical micelle concentration (CMC) of 0.025 mM. CALXGLUK has been used to solubilize a membrane GPCR (MP-A) and a membrane transporter (MP-B) from yeast alone and in combination with Triton X-100 (Item No. 600217) and digitonin (Item No. 14952).  

     

    Brand:
    Cayman
    SKU:24784 - 50 mg

    Available on backorder

  • Calycosin is an isoflavone and phytoestrogen with diverse biological activities.{41872,41873,41874,43143,41875,41876} It is an estrogen receptor (ER) partial agonist that inhibits 17β-estradiol binding to ERα and ERβ (IC50s = 83.14 and 40.38 μM, respectively).{41872} Calycosin induces tube formation by human umbilical vein endothelial cells (HUVECs) in a Matrigel™ assay and angiogenesis in zebrafish via activation of ERs and ERK1/2. It has antiplasmodial and antiprotozoal activities, reducing the growth of the poW and Dd2 strains of P. falciparum (IC50s = 4.2 and 9.8 μg/ml, respectively) and exhibiting selective toxicity for T. brucei brucei over Vero cells (IC50s = 12.7 and 159 μM, respectively).{41873,41874} Calycosin scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) free radicals in a cell-free assay and inhibits xanthine/xanthine oxidase-induced toxicity in PC12 cells (EC50 = 50 ng/ml).{43143} In vivo, calycosin (12.5 and 25 mg/kg) reduces alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, triglyceride accumulation, and hepatic fibrosis in a mouse model of non-alcoholic steatohepatitis (NASH).{41875} It also decreases infarct volume and brain edema in a rat model of focal cerebral ischemia and reperfusion injury.{41876}  

     

    Brand:
    Cayman
    SKU:25091 - 10 mg

    Available on backorder

  • Calycosin is an isoflavone and phytoestrogen with diverse biological activities.{41872,41873,41874,43143,41875,41876} It is an estrogen receptor (ER) partial agonist that inhibits 17β-estradiol binding to ERα and ERβ (IC50s = 83.14 and 40.38 μM, respectively).{41872} Calycosin induces tube formation by human umbilical vein endothelial cells (HUVECs) in a Matrigel™ assay and angiogenesis in zebrafish via activation of ERs and ERK1/2. It has antiplasmodial and antiprotozoal activities, reducing the growth of the poW and Dd2 strains of P. falciparum (IC50s = 4.2 and 9.8 μg/ml, respectively) and exhibiting selective toxicity for T. brucei brucei over Vero cells (IC50s = 12.7 and 159 μM, respectively).{41873,41874} Calycosin scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) free radicals in a cell-free assay and inhibits xanthine/xanthine oxidase-induced toxicity in PC12 cells (EC50 = 50 ng/ml).{43143} In vivo, calycosin (12.5 and 25 mg/kg) reduces alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, triglyceride accumulation, and hepatic fibrosis in a mouse model of non-alcoholic steatohepatitis (NASH).{41875} It also decreases infarct volume and brain edema in a rat model of focal cerebral ischemia and reperfusion injury.{41876}  

     

    Brand:
    Cayman
    SKU:25091 - 25 mg

    Available on backorder

  • Calycosin is an isoflavone and phytoestrogen with diverse biological activities.{41872,41873,41874,43143,41875,41876} It is an estrogen receptor (ER) partial agonist that inhibits 17β-estradiol binding to ERα and ERβ (IC50s = 83.14 and 40.38 μM, respectively).{41872} Calycosin induces tube formation by human umbilical vein endothelial cells (HUVECs) in a Matrigel™ assay and angiogenesis in zebrafish via activation of ERs and ERK1/2. It has antiplasmodial and antiprotozoal activities, reducing the growth of the poW and Dd2 strains of P. falciparum (IC50s = 4.2 and 9.8 μg/ml, respectively) and exhibiting selective toxicity for T. brucei brucei over Vero cells (IC50s = 12.7 and 159 μM, respectively).{41873,41874} Calycosin scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) free radicals in a cell-free assay and inhibits xanthine/xanthine oxidase-induced toxicity in PC12 cells (EC50 = 50 ng/ml).{43143} In vivo, calycosin (12.5 and 25 mg/kg) reduces alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, triglyceride accumulation, and hepatic fibrosis in a mouse model of non-alcoholic steatohepatitis (NASH).{41875} It also decreases infarct volume and brain edema in a rat model of focal cerebral ischemia and reperfusion injury.{41876}  

     

    Brand:
    Cayman
    SKU:25091 - 5 mg

    Available on backorder

  • Calycosin is an isoflavone and phytoestrogen with diverse biological activities.{41872,41873,41874,43143,41875,41876} It is an estrogen receptor (ER) partial agonist that inhibits 17β-estradiol binding to ERα and ERβ (IC50s = 83.14 and 40.38 μM, respectively).{41872} Calycosin induces tube formation by human umbilical vein endothelial cells (HUVECs) in a Matrigel™ assay and angiogenesis in zebrafish via activation of ERs and ERK1/2. It has antiplasmodial and antiprotozoal activities, reducing the growth of the poW and Dd2 strains of P. falciparum (IC50s = 4.2 and 9.8 μg/ml, respectively) and exhibiting selective toxicity for T. brucei brucei over Vero cells (IC50s = 12.7 and 159 μM, respectively).{41873,41874} Calycosin scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) free radicals in a cell-free assay and inhibits xanthine/xanthine oxidase-induced toxicity in PC12 cells (EC50 = 50 ng/ml).{43143} In vivo, calycosin (12.5 and 25 mg/kg) reduces alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, triglyceride accumulation, and hepatic fibrosis in a mouse model of non-alcoholic steatohepatitis (NASH).{41875} It also decreases infarct volume and brain edema in a rat model of focal cerebral ischemia and reperfusion injury.{41876}  

     

    Brand:
    Cayman
    SKU:25091 - 50 mg

    Available on backorder

  • Calycosin 7-O-β-D-glucoside is an isoflavone glycoside that has been isolated from A. mongholicus and A. membranaceus and has antioxidant, anti-inflammatory, and neuroprotective biological activities.{43143,43144,43145} It scavenges 34.5% of generated 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals compared to a vehicle control when used at a concentration of 100 μg/ml in a cell-free assay.{43143} Calycosin 7-O-β-D-glucoside (10 μg/ml) inhibits cytotoxicity, intracellular reactive oxygen species (ROS) production, and cytoskeletal defects induced by LPS in human umbilical vein endothelial cells (HUVECs).{43144} In vivo, calycosin 7-O-β-D-glucoside (26.8 mg/kg) reduces brain infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{43145}  

     

    Brand:
    Cayman
    SKU:25095 - 1 mg

    Available on backorder

  • Calycosin 7-O-β-D-glucoside is an isoflavone glycoside that has been isolated from A. mongholicus and A. membranaceus and has antioxidant, anti-inflammatory, and neuroprotective biological activities.{43143,43144,43145} It scavenges 34.5% of generated 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals compared to a vehicle control when used at a concentration of 100 μg/ml in a cell-free assay.{43143} Calycosin 7-O-β-D-glucoside (10 μg/ml) inhibits cytotoxicity, intracellular reactive oxygen species (ROS) production, and cytoskeletal defects induced by LPS in human umbilical vein endothelial cells (HUVECs).{43144} In vivo, calycosin 7-O-β-D-glucoside (26.8 mg/kg) reduces brain infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{43145}  

     

    Brand:
    Cayman
    SKU:25095 - 10 mg

    Available on backorder

  • Calycosin 7-O-β-D-glucoside is an isoflavone glycoside that has been isolated from A. mongholicus and A. membranaceus and has antioxidant, anti-inflammatory, and neuroprotective biological activities.{43143,43144,43145} It scavenges 34.5% of generated 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals compared to a vehicle control when used at a concentration of 100 μg/ml in a cell-free assay.{43143} Calycosin 7-O-β-D-glucoside (10 μg/ml) inhibits cytotoxicity, intracellular reactive oxygen species (ROS) production, and cytoskeletal defects induced by LPS in human umbilical vein endothelial cells (HUVECs).{43144} In vivo, calycosin 7-O-β-D-glucoside (26.8 mg/kg) reduces brain infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{43145}  

     

    Brand:
    Cayman
    SKU:25095 - 25 mg

    Available on backorder

  • Calycosin 7-O-β-D-glucoside is an isoflavone glycoside that has been isolated from A. mongholicus and A. membranaceus and has antioxidant, anti-inflammatory, and neuroprotective biological activities.{43143,43144,43145} It scavenges 34.5% of generated 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals compared to a vehicle control when used at a concentration of 100 μg/ml in a cell-free assay.{43143} Calycosin 7-O-β-D-glucoside (10 μg/ml) inhibits cytotoxicity, intracellular reactive oxygen species (ROS) production, and cytoskeletal defects induced by LPS in human umbilical vein endothelial cells (HUVECs).{43144} In vivo, calycosin 7-O-β-D-glucoside (26.8 mg/kg) reduces brain infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{43145}  

     

    Brand:
    Cayman
    SKU:25095 - 5 mg

    Available on backorder

  • Calyculin A is a natural, cell-permeable inhibitor of the serine-threonine protein phosphatases (PP) PP1 and PP2A (IC50s = 0.3-0.7 and 0.5-1 nM, respectively).{32313,21678,32314} It is without significant effect against PP2B, PP2C, and PP4.{21678} Through its effects on PP1 and PP2A, calyculin A has been shown to either promote or inhibit cancer cell growth in tumor cell lines and animal models.{32312,18481}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Calyculin A is a natural, cell-permeable inhibitor of the serine-threonine protein phosphatases (PP) PP1 and PP2A (IC50s = 0.3-0.7 and 0.5-1 nM, respectively).{32313,21678,32314} It is without significant effect against PP2B, PP2C, and PP4.{21678} Through its effects on PP1 and PP2A, calyculin A has been shown to either promote or inhibit cancer cell growth in tumor cell lines and animal models.{32312,18481}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Camalexin is an alkaloid released by plants of the Brassicaceae family in response to pathogen infection.{35038} In addition to antimicrobial properties and a role in plant defense, camalexin exhibits antiproliferative activity in vitro against various cancer cell lines.{35039,35040,35041,35042} Camalexin is active against HeLa, Jurkat, MDA-MB-231, and CEM cancer cell lines (IC50s = 50.0, 46.2, 77.7, and 67.6 μM, respectively), but it is also toxic to primary human umbilical vein endothelial cells (HUVEC; (IC50 = 74.0 μM).{35040} Camalexin induces apoptosis in Jurkat cells by increasing reactive oxygen species (ROS) levels and activating caspase-8 and caspase-9.{35039} In human prostate cancer cell lines, camalexin (25 μM) is more active against aggressive lines and increases ROS levels and apoptosis via cathepsin D relocation from lysosomes to the cytosol.{35042,35043}  

     

    Brand:
    Cayman
    SKU:21971 -

    Out of stock

  • Camalexin is an alkaloid released by plants of the Brassicaceae family in response to pathogen infection.{35038} In addition to antimicrobial properties and a role in plant defense, camalexin exhibits antiproliferative activity in vitro against various cancer cell lines.{35039,35040,35041,35042} Camalexin is active against HeLa, Jurkat, MDA-MB-231, and CEM cancer cell lines (IC50s = 50.0, 46.2, 77.7, and 67.6 μM, respectively), but it is also toxic to primary human umbilical vein endothelial cells (HUVEC; (IC50 = 74.0 μM).{35040} Camalexin induces apoptosis in Jurkat cells by increasing reactive oxygen species (ROS) levels and activating caspase-8 and caspase-9.{35039} In human prostate cancer cell lines, camalexin (25 μM) is more active against aggressive lines and increases ROS levels and apoptosis via cathepsin D relocation from lysosomes to the cytosol.{35042,35043}  

     

    Brand:
    Cayman
    SKU:21971 -

    Out of stock

  • Camalexin is an alkaloid released by plants of the Brassicaceae family in response to pathogen infection.{35038} In addition to antimicrobial properties and a role in plant defense, camalexin exhibits antiproliferative activity in vitro against various cancer cell lines.{35039,35040,35041,35042} Camalexin is active against HeLa, Jurkat, MDA-MB-231, and CEM cancer cell lines (IC50s = 50.0, 46.2, 77.7, and 67.6 μM, respectively), but it is also toxic to primary human umbilical vein endothelial cells (HUVEC; (IC50 = 74.0 μM).{35040} Camalexin induces apoptosis in Jurkat cells by increasing reactive oxygen species (ROS) levels and activating caspase-8 and caspase-9.{35039} In human prostate cancer cell lines, camalexin (25 μM) is more active against aggressive lines and increases ROS levels and apoptosis via cathepsin D relocation from lysosomes to the cytosol.{35042,35043}  

     

    Brand:
    Cayman
    SKU:21971 -

    Out of stock

  • Cambendazol is an antihelmintic that, at a dose of 50 mg/kg/day in mice, eradicates S. ratti adult worms from intestine and S. stercoralis larva from muscle.{39137} It inhibits polymerization of microtubules isolated from bovine brain with an IC50 value of 64.2 µM.{39138} Formulations containing cambendazol have been used to treat strongyloidiasis in humans and have been studied as potential chemotherapeutics.{39136,39139}  

     

    Brand:
    Cayman
    SKU:20841 -

    Out of stock

  • Cambendazol is an antihelmintic that, at a dose of 50 mg/kg/day in mice, eradicates S. ratti adult worms from intestine and S. stercoralis larva from muscle.{39137} It inhibits polymerization of microtubules isolated from bovine brain with an IC50 value of 64.2 µM.{39138} Formulations containing cambendazol have been used to treat strongyloidiasis in humans and have been studied as potential chemotherapeutics.{39136,39139}  

     

    Brand:
    Cayman
    SKU:20841 -

    Out of stock

  • Cambendazol is an antihelmintic that, at a dose of 50 mg/kg/day in mice, eradicates S. ratti adult worms from intestine and S. stercoralis larva from muscle.{39137} It inhibits polymerization of microtubules isolated from bovine brain with an IC50 value of 64.2 µM.{39138} Formulations containing cambendazol have been used to treat strongyloidiasis in humans and have been studied as potential chemotherapeutics.{39136,39139}  

     

    Brand:
    Cayman
    SKU:20841 -

    Out of stock

  • Cambendazol is an antihelmintic that, at a dose of 50 mg/kg/day in mice, eradicates S. ratti adult worms from intestine and S. stercoralis larva from muscle.{39137} It inhibits polymerization of microtubules isolated from bovine brain with an IC50 value of 64.2 µM.{39138} Formulations containing cambendazol have been used to treat strongyloidiasis in humans and have been studied as potential chemotherapeutics.{39136,39139}  

     

    Brand:
    Cayman
    SKU:20841 -

    Out of stock

  • Immunogen: Phosphopeptide corresponding to amino acid residues surrounding phospho-Thr286 of rat CaM Kinase II • Host: Rabbit • Species Reactivity: (+) Human, Mouse, Rabbit, Rat • Applications: IHC and WB • MW = ~50 and 60 kDa for CaMKIIα phospho-Thr286 and CaMKIIβ phospho-Thr286, respectively  

     

    Brand:
    Cayman
    SKU:29253- 100 µl
  • Calcium/calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine protein kinase and member of the calcium/calmodulin-activated protein kinase family.{53680,15705,15706} There are four isoforms of CaMKII, α, β, γ, and δ, encoded by CaMK2A, CaMK2B, CaMK2G, and CaMK2D in humans.{53680} CaMKIIα and CaMKIIβ are predominantly expressed in neuronal tissue, while CaMKIIγ and CaMKIIδ are primarily found in cardiac tissue, however, the various isoforms of CaMKII can be found in nearly all cell types. Upon calcium binding, CaMKII undergoes a conformational switch that displaces the autoinhibitory domain inducing autophosphorylation of threonine 286 (Thr286) and autonomous activation of the kinase.{15712} Activation of CaMKII in dendritic spines in response to increased calcium concentration facilitates the induction of long term potentiation (LTP) and memory formation in rodents.{53681} Phospho-site mutant Camk2aT286A knock-in mice exhibit impaired LTP, as well as learning and memory deficits.{53681} Cayman’s CaMKII (Phospho-Thr286) Polyclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes CaMKIIα phospho-Thr286 and CaMKIIβ phospho-Thr286 at approximately 50 and 60 kDa, respectively, from human, mouse, rabbit, and rat samples.  

     

    Brand:
    Cayman
    SKU:29253 - 100 µl

    Available on backorder

  • Immunogen: Phosphopeptide corresponding to amino acid residues surrounding phospho-Thr286 of rat CaM Kinase II • Host: Rabbit • Species Reactivity: (+) Human, Mouse, Rabbit, Rat • Applications: IHC and WB • MW = ~50 and 60 kDa for CaMKIIα phospho-Thr286 and CaMKIIβ phospho-Thr286, respectively  

     

    Brand:
    Cayman
    SKU:29253- 100 µl

    Available on backorder

  • Antigen: mouse recombinant CaMKII • Host: mouse, clone 22B1 • Isotype: IgG1 • Cross Reactivity: (+) rat CaMKII • Application(s): ELISA, IF, IP, and WB • CaMKII functions in neural synaptic stimulation and T-cell receptor signaling. The binding of Ca2+/calmodulin to its regulatory domain releases its auto inhibitory effect and activates the kinase. This kinase activation results in autophosphorylation at Thr286. PP1 dephosphorylates phospho-CaMKII at Thr286 and PKA prevents this dephosphorylation.  

     

    Brand:
    Cayman
    SKU:10011438- 100 µg
  • CaMKII is an important member of the calcium/calmodulin-activated protein kinase family, functioning in neural synaptic stimulation and T-cell receptor signaling.{15705,15706} CaMKII is expressed in many different tissues but is specifically found in the neurons of the forebrain and its mRNA is found within the dendrites and the soma of the neuron. The CaMKII that is found in the neurons consists of two subunits of 52 (termed α genes) and 60 kDa (β genes). CaMKII has catalytic and regulatory domains, as well as an ATP-binding domain, and a consensus phosphorylation site.{15707,15708,15709,15710,15711} The binding of Ca2+/calmodulin to its regulatory domain releases its auto inhibitory effect and activates the kinase.{15712} This kinase activation results in autophosphorylation at threonine 286 (Thr286).{15712} The threonine phosphorylation state of CaMKII can be regulated through protein phosphatase 1 (PP1)/protein kinase A (PKA). Whereas PP1 dephosphorylates phospho-CaMKII at Thr286, PKA prevents this dephosphorylation.{15713} Autophosphorylation also enables CaMKII to attain an enhanced affinity for NMDA receptors in postsynaptic densities.{15714,15715,15716}  

     

    Brand:
    Cayman
    SKU:10011438 - 100 µg

    Available on backorder

  • Antigen: mouse recombinant CaMKII • Host: mouse, clone 22B1 • Isotype: IgG1 • Cross Reactivity: (+) rat CaMKII • Application(s): ELISA, IF, IP, and WB • CaMKII functions in neural synaptic stimulation and T-cell receptor signaling. The binding of Ca2+/calmodulin to its regulatory domain releases its auto inhibitory effect and activates the kinase. This kinase activation results in autophosphorylation at Thr286. PP1 dephosphorylates phospho-CaMKII at Thr286 and PKA prevents this dephosphorylation.  

     

    Brand:
    Cayman
    SKU:10011438- 100 µg

    Available on backorder

  • Antigen: mouse recombinant CaMKII • Host: mouse, clone 22B1 • Isotype: IgG1 • Cross Reactivity: (+) rat CaMKII • Application(s): ELISA, IF, IP, and WB • CaMKII functions in neural synaptic stimulation and T-cell receptor signaling. The binding of Ca2+/calmodulin to its regulatory domain releases its auto inhibitory effect and activates the kinase. This kinase activation results in autophosphorylation at Thr286. PP1 dephosphorylates phospho-CaMKII at Thr286 and PKA prevents this dephosphorylation.  

     

    Brand:
    Cayman
    SKU:10011438- 25 µg
  • CaMKII is an important member of the calcium/calmodulin-activated protein kinase family, functioning in neural synaptic stimulation and T-cell receptor signaling.{15705,15706} CaMKII is expressed in many different tissues but is specifically found in the neurons of the forebrain and its mRNA is found within the dendrites and the soma of the neuron. The CaMKII that is found in the neurons consists of two subunits of 52 (termed α genes) and 60 kDa (β genes). CaMKII has catalytic and regulatory domains, as well as an ATP-binding domain, and a consensus phosphorylation site.{15707,15708,15709,15710,15711} The binding of Ca2+/calmodulin to its regulatory domain releases its auto inhibitory effect and activates the kinase.{15712} This kinase activation results in autophosphorylation at threonine 286 (Thr286).{15712} The threonine phosphorylation state of CaMKII can be regulated through protein phosphatase 1 (PP1)/protein kinase A (PKA). Whereas PP1 dephosphorylates phospho-CaMKII at Thr286, PKA prevents this dephosphorylation.{15713} Autophosphorylation also enables CaMKII to attain an enhanced affinity for NMDA receptors in postsynaptic densities.{15714,15715,15716}  

     

    Brand:
    Cayman
    SKU:10011438 - 25 µg

    Available on backorder

  • Antigen: mouse recombinant CaMKII • Host: mouse, clone 22B1 • Isotype: IgG1 • Cross Reactivity: (+) rat CaMKII • Application(s): ELISA, IF, IP, and WB • CaMKII functions in neural synaptic stimulation and T-cell receptor signaling. The binding of Ca2+/calmodulin to its regulatory domain releases its auto inhibitory effect and activates the kinase. This kinase activation results in autophosphorylation at Thr286. PP1 dephosphorylates phospho-CaMKII at Thr286 and PKA prevents this dephosphorylation.  

     

    Brand:
    Cayman
    SKU:10011438- 25 µg

    Available on backorder

  • Antigen: rat recombinant CaMKII • Host: mouse, clone 6G9 • Isotype: IgG1 • Cross Reactivity: (+) mouse, rat, and bovine CaMKII • Application(s): ELISA, IF, IHC, IP, and WB • CaMKII functions in neural synaptic stimulation and T cell receptor signaling. The binding of Ca2+/calmodulin to its regulatory domain releases its auto inhibitory effect and activates the kinase. This kinase activation results in autophosphorylation at Thr286. PP1 dephosphorylates phospho-CaMKII at Thr286 and PKA prevents this dephosphorylation.  

     

    Brand:
    Cayman
    SKU:10011437- 100 µg
  • CaMKII is an important member of the calcium/calmodulin-activated protein kinase family, functioning in neural synaptic stimulation and T-cell receptor signaling.{15705,15706} CaMKII is expressed in many different tissues but is specifically found in neurons of the forebrain and its mRNA is found within the dendrites and the soma of the neuron. The CaMKII that is found in the neurons consist of two subunits of 52 (termed α genes) and 60 kDa (β genes). CaMKII has catalytic and regulatory domains, as well as an ATP-binding domain, and a consensus phosphorylation site.{15707,15708,15709,15710,15711} The binding of Ca2+/calmodulin to its regulatory domain releases its auto inhibitory effect and activates the kinase.{15712} This kinase activation results in autophosphorylation at threonine 286 (Thr286).{15712} The threonine phosphorylation state of CaMKII can be regulated through protein phosphatase 1 (PP1)/protein kinase A (PKA). Whereas PP1 dephosphorylates phospho-CaMKII at Thr286, PKA prevents this dephosphorylation.{15713} Autophosphorylation also enables CaMKII to attain an enhanced affinity for NMDA receptors in postsynaptic densities.{15714,15715,15716}  

     

    Brand:
    Cayman
    SKU:10011437 - 100 µg

    Available on backorder

  • Antigen: rat recombinant CaMKII • Host: mouse, clone 6G9 • Isotype: IgG1 • Cross Reactivity: (+) mouse, rat, and bovine CaMKII • Application(s): ELISA, IF, IHC, IP, and WB • CaMKII functions in neural synaptic stimulation and T cell receptor signaling. The binding of Ca2+/calmodulin to its regulatory domain releases its auto inhibitory effect and activates the kinase. This kinase activation results in autophosphorylation at Thr286. PP1 dephosphorylates phospho-CaMKII at Thr286 and PKA prevents this dephosphorylation.  

     

    Brand:
    Cayman
    SKU:10011437- 100 µg

    Available on backorder

  • Antigen: rat recombinant CaMKII • Host: mouse, clone 6G9 • Isotype: IgG1 • Cross Reactivity: (+) mouse, rat, and bovine CaMKII • Application(s): ELISA, IF, IHC, IP, and WB • CaMKII functions in neural synaptic stimulation and T cell receptor signaling. The binding of Ca2+/calmodulin to its regulatory domain releases its auto inhibitory effect and activates the kinase. This kinase activation results in autophosphorylation at Thr286. PP1 dephosphorylates phospho-CaMKII at Thr286 and PKA prevents this dephosphorylation.  

     

    Brand:
    Cayman
    SKU:10011437- 25 µg
  • CaMKII is an important member of the calcium/calmodulin-activated protein kinase family, functioning in neural synaptic stimulation and T-cell receptor signaling.{15705,15706} CaMKII is expressed in many different tissues but is specifically found in neurons of the forebrain and its mRNA is found within the dendrites and the soma of the neuron. The CaMKII that is found in the neurons consist of two subunits of 52 (termed α genes) and 60 kDa (β genes). CaMKII has catalytic and regulatory domains, as well as an ATP-binding domain, and a consensus phosphorylation site.{15707,15708,15709,15710,15711} The binding of Ca2+/calmodulin to its regulatory domain releases its auto inhibitory effect and activates the kinase.{15712} This kinase activation results in autophosphorylation at threonine 286 (Thr286).{15712} The threonine phosphorylation state of CaMKII can be regulated through protein phosphatase 1 (PP1)/protein kinase A (PKA). Whereas PP1 dephosphorylates phospho-CaMKII at Thr286, PKA prevents this dephosphorylation.{15713} Autophosphorylation also enables CaMKII to attain an enhanced affinity for NMDA receptors in postsynaptic densities.{15714,15715,15716}  

     

    Brand:
    Cayman
    SKU:10011437 - 25 µg

    Available on backorder

  • Antigen: rat recombinant CaMKII • Host: mouse, clone 6G9 • Isotype: IgG1 • Cross Reactivity: (+) mouse, rat, and bovine CaMKII • Application(s): ELISA, IF, IHC, IP, and WB • CaMKII functions in neural synaptic stimulation and T cell receptor signaling. The binding of Ca2+/calmodulin to its regulatory domain releases its auto inhibitory effect and activates the kinase. This kinase activation results in autophosphorylation at Thr286. PP1 dephosphorylates phospho-CaMKII at Thr286 and PKA prevents this dephosphorylation.  

     

    Brand:
    Cayman
    SKU:10011437- 25 µg

    Available on backorder

  • Camostat is a protease inhibitor.{26053,26054} It inhibits trypsin (Ki = 1 nM), as well as various inflammatory proteases, including plasmin, kallikrein, and thrombin. Camostat (50 µM) inhibits entry of vesicular stomatitis virus (VSV) particles pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 surface glycoprotein in Calu-3 cells and primary human lung epithelial cells.{49542} It reduces the number of SARS-CoV-2 genomic equivalents, a marker of infection, in Calu-3 cells. Camostat inhibits sodium channel function in human airway epithelial cells (IC50 = 50 nM) and enhances mucociliary clearance in sheep.{26503} Dietary administration of camostat (1 mg/kg) inhibits the production of TNF-α and chemokine (C-C motif) ligand 2 (CCL2) by monocytes, as well as proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis.{26054}  

     

    Brand:
    Cayman
    SKU:-
  • Camostat is a protease inhibitor.{26053,26054} It inhibits trypsin (Ki = 1 nM), as well as various inflammatory proteases, including plasmin, kallikrein, and thrombin. Camostat (50 µM) inhibits entry of vesicular stomatitis virus (VSV) particles pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 surface glycoprotein in Calu-3 cells and primary human lung epithelial cells.{49542} It reduces the number of SARS-CoV-2 genomic equivalents, a marker of infection, in Calu-3 cells. Camostat inhibits sodium channel function in human airway epithelial cells (IC50 = 50 nM) and enhances mucociliary clearance in sheep.{26503} Dietary administration of camostat (1 mg/kg) inhibits the production of TNF-α and chemokine (C-C motif) ligand 2 (CCL2) by monocytes, as well as proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis.{26054}  

     

    Brand:
    Cayman
    SKU:-
  • Camostat is a protease inhibitor.{26053,26054} It inhibits trypsin (Ki = 1 nM), as well as various inflammatory proteases, including plasmin, kallikrein, and thrombin. Camostat (50 µM) inhibits entry of vesicular stomatitis virus (VSV) particles pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 surface glycoprotein in Calu-3 cells and primary human lung epithelial cells.{49542} It reduces the number of SARS-CoV-2 genomic equivalents, a marker of infection, in Calu-3 cells. Camostat inhibits sodium channel function in human airway epithelial cells (IC50 = 50 nM) and enhances mucociliary clearance in sheep.{26503} Dietary administration of camostat (1 mg/kg) inhibits the production of TNF-α and chemokine (C-C motif) ligand 2 (CCL2) by monocytes, as well as proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis.{26054}  

     

    Brand:
    Cayman
    SKU:-
  • Camostat is a protease inhibitor.{26053,26054} It inhibits trypsin (Ki = 1 nM), as well as various inflammatory proteases, including plasmin, kallikrein, and thrombin. Camostat (50 µM) inhibits entry of vesicular stomatitis virus (VSV) particles pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 surface glycoprotein in Calu-3 cells and primary human lung epithelial cells.{49542} It reduces the number of SARS-CoV-2 genomic equivalents, a marker of infection, in Calu-3 cells. Camostat inhibits sodium channel function in human airway epithelial cells (IC50 = 50 nM) and enhances mucociliary clearance in sheep.{26503} Dietary administration of camostat (1 mg/kg) inhibits the production of TNF-α and chemokine (C-C motif) ligand 2 (CCL2) by monocytes, as well as proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis.{26054}  

     

    Brand:
    Cayman
    SKU:-
  • Campestanol is a phytosterol found in vegetables, fruits, nuts, and seeds.{47133} Dietary administration of vegetable stanol esters (1% w/w) containing campestanol (30.1%) and sitostanol (65.7%; Item No. 26094) lower serum cholesterol, LDL, VLDL, and intermediate-density lipoprotein (IDL) cholesterol levels in an APOE*3-Leiden transgenic mouse model of atherosclerosis.{47134} This combination of campestanol with sitostanol also reduces atherosclerotic lesion area by 91% and the proportion of lesions with extensive macrophage infiltration.  

     

    Brand:
    Cayman
    SKU:26538 - 1 mg

    Available on backorder

  • Campestanol is a phytosterol found in vegetables, fruits, nuts, and seeds.{47133} Dietary administration of vegetable stanol esters (1% w/w) containing campestanol (30.1%) and sitostanol (65.7%; Item No. 26094) lower serum cholesterol, LDL, VLDL, and intermediate-density lipoprotein (IDL) cholesterol levels in an APOE*3-Leiden transgenic mouse model of atherosclerosis.{47134} This combination of campestanol with sitostanol also reduces atherosclerotic lesion area by 91% and the proportion of lesions with extensive macrophage infiltration.  

     

    Brand:
    Cayman
    SKU:26538 - 500 µg

    Available on backorder

  • Canagliflozin is an inhibitor of sodium-glucose cotransporter 2 (SGLT2; IC50 = 2.2 nM) that less potently blocks SGLT1 (IC50 = 910 nM).{18745} Canagliflozin is orally bioavailable and lowers plasma glucose by lowering the renal threshold for glucose and increasing urinary glucose excretion in animals.{18745,33510} Formulations containing SGLT2 inhibitors, including canagliflozin, are used to treat type 2 diabetes mellitus.{33509}  

     

    Brand:
    Cayman
    SKU:11575 - 10 mg

    Available on backorder

  • Canagliflozin is an inhibitor of sodium-glucose cotransporter 2 (SGLT2; IC50 = 2.2 nM) that less potently blocks SGLT1 (IC50 = 910 nM).{18745} Canagliflozin is orally bioavailable and lowers plasma glucose by lowering the renal threshold for glucose and increasing urinary glucose excretion in animals.{18745,33510} Formulations containing SGLT2 inhibitors, including canagliflozin, are used to treat type 2 diabetes mellitus.{33509}  

     

    Brand:
    Cayman
    SKU:11575 - 25 mg

    Available on backorder

  • Canagliflozin is an inhibitor of sodium-glucose cotransporter 2 (SGLT2; IC50 = 2.2 nM) that less potently blocks SGLT1 (IC50 = 910 nM).{18745} Canagliflozin is orally bioavailable and lowers plasma glucose by lowering the renal threshold for glucose and increasing urinary glucose excretion in animals.{18745,33510} Formulations containing SGLT2 inhibitors, including canagliflozin, are used to treat type 2 diabetes mellitus.{33509}  

     

    Brand:
    Cayman
    SKU:11575 - 5 mg

    Available on backorder

  • Canagliflozin is an inhibitor of sodium-glucose cotransporter 2 (SGLT2; IC50 = 2.2 nM) that less potently blocks SGLT1 (IC50 = 910 nM).{18745} Canagliflozin is orally bioavailable and lowers plasma glucose by lowering the renal threshold for glucose and increasing urinary glucose excretion in animals.{18745,33510} Formulations containing SGLT2 inhibitors, including canagliflozin, are used to treat type 2 diabetes mellitus.{33509}  

     

    Brand:
    Cayman
    SKU:11575 - 50 mg

    Available on backorder

  • Canagliflozin-d4 is intended for use as an internal standard for the quantification of canagliflozin (Item No. 11575) by GC- or LC-MS. Canagliflozin is an inhibitor of sodium-glucose cotransporter 2 (SGLT2; IC50 = 2.2 nM) that less potently blocks SGLT1 (IC50 = 910 nM).{18745} Canagliflozin is orally bioavailable and lowers plasma glucose by lowering the renal threshold for glucose and increasing urinary glucose excretion in animals.{18745,33510} Formulations containing SGLT2 inhibitors, including canagliflozin, have been used to treat type 2 diabetes mellitus.{33509}  

     

    Brand:
    Cayman
    SKU:25223 - 1 mg

    Available on backorder

  • Angiotensin receptor blockers effectively protect against the harmful effects of the activation of the renin-angiotensin-aldosterone system that occur with hypertension or diabetes.{18424} Candesartan cilexetil is a prodrug of the potent, long-acting, and selective angiotensin II type 1 receptor (AT1) antagonist, candesartan. It is rapidly hydrolyzed to candesartan during gastrointestinal absorption. Clinical trials indicate a 4-16 mg/day dose of candesartan cilexetil effectively reduces diastolic blood pressure.{18425} In addition to its anti-hypertensive properties, blockade of AT1 receptors with 10 mg/kg/day candesartan cilexetil in cold-restraint stressed SHR rats prevents stress-induced tyrosine hydroxylase transcription and increases AT2 receptor expression in the ventrolateral thalamic nucleus, suggesting a therapeutic role in stress-related disorders.{18423}  

     

    Brand:
    Cayman
    SKU:10489 - 1 g

    Available on backorder

  • Angiotensin receptor blockers effectively protect against the harmful effects of the activation of the renin-angiotensin-aldosterone system that occur with hypertension or diabetes.{18424} Candesartan cilexetil is a prodrug of the potent, long-acting, and selective angiotensin II type 1 receptor (AT1) antagonist, candesartan. It is rapidly hydrolyzed to candesartan during gastrointestinal absorption. Clinical trials indicate a 4-16 mg/day dose of candesartan cilexetil effectively reduces diastolic blood pressure.{18425} In addition to its anti-hypertensive properties, blockade of AT1 receptors with 10 mg/kg/day candesartan cilexetil in cold-restraint stressed SHR rats prevents stress-induced tyrosine hydroxylase transcription and increases AT2 receptor expression in the ventrolateral thalamic nucleus, suggesting a therapeutic role in stress-related disorders.{18423}  

     

    Brand:
    Cayman
    SKU:10489 - 10 g

    Available on backorder

  • Angiotensin receptor blockers effectively protect against the harmful effects of the activation of the renin-angiotensin-aldosterone system that occur with hypertension or diabetes.{18424} Candesartan cilexetil is a prodrug of the potent, long-acting, and selective angiotensin II type 1 receptor (AT1) antagonist, candesartan. It is rapidly hydrolyzed to candesartan during gastrointestinal absorption. Clinical trials indicate a 4-16 mg/day dose of candesartan cilexetil effectively reduces diastolic blood pressure.{18425} In addition to its anti-hypertensive properties, blockade of AT1 receptors with 10 mg/kg/day candesartan cilexetil in cold-restraint stressed SHR rats prevents stress-induced tyrosine hydroxylase transcription and increases AT2 receptor expression in the ventrolateral thalamic nucleus, suggesting a therapeutic role in stress-related disorders.{18423}  

     

    Brand:
    Cayman
    SKU:10489 - 5 g

    Available on backorder

  • Angiotensin receptor blockers effectively protect against the harmful effects of the activation of the renin-angiotensin-aldosterone system that occur with hypertension or diabetes.{18424} Candesartan cilexetil is a prodrug of the potent, long-acting, and selective angiotensin II type 1 receptor (AT1) antagonist, candesartan. It is rapidly hydrolyzed to candesartan during gastrointestinal absorption. Clinical trials indicate a 4-16 mg/day dose of candesartan cilexetil effectively reduces diastolic blood pressure.{18425} In addition to its anti-hypertensive properties, blockade of AT1 receptors with 10 mg/kg/day candesartan cilexetil in cold-restraint stressed SHR rats prevents stress-induced tyrosine hydroxylase transcription and increases AT2 receptor expression in the ventrolateral thalamic nucleus, suggesting a therapeutic role in stress-related disorders.{18423}  

     

    Brand:
    Cayman
    SKU:10489 - 500 mg

    Available on backorder

  • Candesartan-d4 is intended for use as an internal standard for the quantification of candesartan by GC- or LC-MS. Candesartan is an inhibitor of the angiotensin II type 1 (AT1) receptor (Kis = 0.17, 0.12, and 0.12 nM for human AT1, rat AT1A, and rat AT1B recombinant receptors, respectively).{28032} It is selective for AT1 over AT2 receptors (Ki = 26,500 nM for the human recombinant AT2 receptor). It inhibits angiotensin II-induced contraction of isolated rabbit aortic strips and increases in blood pressure in rats following intravenous administration (ID50 = 0.033 mg/kg).{42295} Candesartan is a metabolite of the orally bioavailable prodrug candesartan cilexetil (Item No. 10489). Formulations containing candesartan have been used in the treatment of hypertension and heart failure.  

     

    Brand:
    Cayman
    SKU:25419 - 1 mg

    Available on backorder

  • Candesartan-d4 is intended for use as an internal standard for the quantification of candesartan by GC- or LC-MS. Candesartan is an inhibitor of the angiotensin II type 1 (AT1) receptor (Kis = 0.17, 0.12, and 0.12 nM for human AT1, rat AT1A, and rat AT1B recombinant receptors, respectively).{28032} It is selective for AT1 over AT2 receptors (Ki = 26,500 nM for the human recombinant AT2 receptor). It inhibits angiotensin II-induced contraction of isolated rabbit aortic strips and increases in blood pressure in rats following intravenous administration (ID50 = 0.033 mg/kg).{42295} Candesartan is a metabolite of the orally bioavailable prodrug candesartan cilexetil (Item No. 10489). Formulations containing candesartan have been used in the treatment of hypertension and heart failure.  

     

    Brand:
    Cayman
    SKU:25419 - 5 mg

    Available on backorder

  • The HER family of receptor tyrosine kinases, EGFR, HER2, HER3, and HER4, mediate proliferation, migration, adhesion, differentiation, and survival in many different cell types and have been implicated in the development and progression of a variety of human tumors.{21790} Canertinib is an irreversible quinazoline-based HER family tyrosine kinase inhibitor with IC50 values of 0.8, 19, and 7 nM for blocking in vitro activity of EGFR, HER2, and HER4, respectively.{21790} As a broadly applicable anti-cancer agent, it has been used to suppress proliferation of malignant peripheral nerve sheath tumor cells (effective concentration of 250-500 nM), to inhibit growth and induce dose-dependent apoptosis in a panel of neuroblastoma cell lines (IC50s = 0.94-2.45 μM), and to reduce proliferation of acute myeloid leukemia cells (IC50 = 0.27 μM).{21791,21789,21793} Canertinib also displays anti-neoplastic activity towards T98G glioblastoma cells, HCT8 colorectal carcinoma cells, and cells expressing the breast cancer resistance protein.{21792}  

     

    Brand:
    Cayman
    SKU:12076 - 10 mg

    Available on backorder

  • The HER family of receptor tyrosine kinases, EGFR, HER2, HER3, and HER4, mediate proliferation, migration, adhesion, differentiation, and survival in many different cell types and have been implicated in the development and progression of a variety of human tumors.{21790} Canertinib is an irreversible quinazoline-based HER family tyrosine kinase inhibitor with IC50 values of 0.8, 19, and 7 nM for blocking in vitro activity of EGFR, HER2, and HER4, respectively.{21790} As a broadly applicable anti-cancer agent, it has been used to suppress proliferation of malignant peripheral nerve sheath tumor cells (effective concentration of 250-500 nM), to inhibit growth and induce dose-dependent apoptosis in a panel of neuroblastoma cell lines (IC50s = 0.94-2.45 μM), and to reduce proliferation of acute myeloid leukemia cells (IC50 = 0.27 μM).{21791,21789,21793} Canertinib also displays anti-neoplastic activity towards T98G glioblastoma cells, HCT8 colorectal carcinoma cells, and cells expressing the breast cancer resistance protein.{21792}  

     

    Brand:
    Cayman
    SKU:12076 - 25 mg

    Available on backorder

  • The HER family of receptor tyrosine kinases, EGFR, HER2, HER3, and HER4, mediate proliferation, migration, adhesion, differentiation, and survival in many different cell types and have been implicated in the development and progression of a variety of human tumors.{21790} Canertinib is an irreversible quinazoline-based HER family tyrosine kinase inhibitor with IC50 values of 0.8, 19, and 7 nM for blocking in vitro activity of EGFR, HER2, and HER4, respectively.{21790} As a broadly applicable anti-cancer agent, it has been used to suppress proliferation of malignant peripheral nerve sheath tumor cells (effective concentration of 250-500 nM), to inhibit growth and induce dose-dependent apoptosis in a panel of neuroblastoma cell lines (IC50s = 0.94-2.45 μM), and to reduce proliferation of acute myeloid leukemia cells (IC50 = 0.27 μM).{21791,21789,21793} Canertinib also displays anti-neoplastic activity towards T98G glioblastoma cells, HCT8 colorectal carcinoma cells, and cells expressing the breast cancer resistance protein.{21792}  

     

    Brand:
    Cayman
    SKU:12076 - 5 mg

    Available on backorder

  • The HER family of receptor tyrosine kinases, EGFR, HER2, HER3, and HER4, mediate proliferation, migration, adhesion, differentiation, and survival in many different cell types and have been implicated in the development and progression of a variety of human tumors.{21790} Canertinib is an irreversible quinazoline-based HER family tyrosine kinase inhibitor with IC50 values of 0.8, 19, and 7 nM for blocking in vitro activity of EGFR, HER2, and HER4, respectively.{21790} As a broadly applicable anti-cancer agent, it has been used to suppress proliferation of malignant peripheral nerve sheath tumor cells (effective concentration of 250-500 nM), to inhibit growth and induce dose-dependent apoptosis in a panel of neuroblastoma cell lines (IC50s = 0.94-2.45 μM), and to reduce proliferation of acute myeloid leukemia cells (IC50 = 0.27 μM).{21791,21789,21793} Canertinib also displays anti-neoplastic activity towards T98G glioblastoma cells, HCT8 colorectal carcinoma cells, and cells expressing the breast cancer resistance protein.{21792}  

     

    Brand:
    Cayman
    SKU:12076 - 50 mg

    Available on backorder

  • Cangrelor is an ATP analog that inhibits platelet aggregation (IC50 = 0.4 nM).{40206} It is a reversible competitive antagonist of the platelet purinergic P2Y12 receptor.{23699,40207} Pretreatment with cangrelor significantly reduces blood clotting induced by ADP in a mouse model of pulmonary thromboembolism.{40208} Formulations containing cangrelor have been used to prevent blood clotting in at-risk patients.{40209}  

     

    Brand:
    Cayman
    SKU:22086 -

    Out of stock

  • Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides.{346} The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer.{1462} CBDD is a cannabidiol derivative that potently and selectively inhibits 15-LO with an IC50 value of 0.28 µM.{17111} It does not inhibit 5-LO effectively (IC50 >200 µM).{17111}  

     

    Brand:
    Cayman
    SKU:-
  • Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides.{346} The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer.{1462} CBDD is a cannabidiol derivative that potently and selectively inhibits 15-LO with an IC50 value of 0.28 µM.{17111} It does not inhibit 5-LO effectively (IC50 >200 µM).{17111}  

     

    Brand:
    Cayman
    SKU:-
  • Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides.{346} The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer.{1462} CBDD is a cannabidiol derivative that potently and selectively inhibits 15-LO with an IC50 value of 0.28 µM.{17111} It does not inhibit 5-LO effectively (IC50 >200 µM).{17111}  

     

    Brand:
    Cayman
    SKU:-
  • Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides.{346} The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer.{1462} CBDD is a cannabidiol derivative that potently and selectively inhibits 15-LO with an IC50 value of 0.28 µM.{17111} It does not inhibit 5-LO effectively (IC50 >200 µM).{17111}  

     

    Brand:
    Cayman
    SKU:-
  • Cannabidiolic acid methyl ester (Item No. 28347) is an analytical reference standard that is the methyl ester form of cannabidiolic acid (Item No. 18090). Cannabidiolic acid methyl ester has analgesic activity in rats.{52792} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:28347 - 1 mg

    Available on backorder

  • Cannabidiolic acid methyl ester (Item No. 28347) is an analytical reference standard that is the methyl ester form of cannabidiolic acid (Item No. 18090). Cannabidiolic acid methyl ester has analgesic activity in rats.{52792} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:28347 - 5 mg

    Available on backorder

  • Cannabielsoin (Item No. 21092) is an analytical reference standard categorized as a phytocannabinoid metabolite.{61035,61036} Cannabielsoin is a metabolite of cannabidiol (CBD; Item Nos. ISO60156 | 90080). This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:21092 -

    Out of stock

  • Cannabielsoin (Item No. 21092) is an analytical reference standard categorized as a phytocannabinoid metabolite.{61035,61036} Cannabielsoin is a metabolite of cannabidiol (CBD; Item Nos. ISO60156 | 90080). This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:21092 -

    Out of stock

  • Cannabigerorcin (Item No. 23257) is an analytical reference standard categorized as a phytocannabinoid.{38471} This product is intended for research and forensic applications. This item has been tested to contain ≤0.3% Δ9-THC on a dry weight basis meeting the 2018 Farm Bill requirements to be a non-controlled substance in the U.S.  

     

    Brand:
    Cayman
    SKU:23257 - 1 mg

    Available on backorder

  • Cannabigerorcin (Item No. 23257) is an analytical reference standard categorized as a phytocannabinoid.{38471} This product is intended for research and forensic applications. This item has been tested to contain ≤0.3% Δ9-THC on a dry weight basis meeting the 2018 Farm Bill requirements to be a non-controlled substance in the U.S.  

     

    Brand:
    Cayman
    SKU:23257 - 5 mg

    Available on backorder

  • Cannabigerorcinic acid (Item No. 23258) is an analytical reference standard that is structurally similar to known phytocannabinoids. Cannabigerorcinic acid is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications. This item has been tested to contain ≤0.3% Δ9-THC on a dry weight basis meeting the 2018 Farm Bill requirements to be a non-controlled substance in the U.S.  

     

    Brand:
    Cayman
    SKU:23258 - 1 mg

    Available on backorder

  • Cannabigerorcinic acid (Item No. 23258) is an analytical reference standard that is structurally similar to known phytocannabinoids. Cannabigerorcinic acid is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications. This item has been tested to contain ≤0.3% Δ9-THC on a dry weight basis meeting the 2018 Farm Bill requirements to be a non-controlled substance in the U.S.  

     

    Brand:
    Cayman
    SKU:23258 - 5 mg

    Available on backorder

  • Cannabinodiol (Item No. 9002479) is an analytical reference standard that is categorized as a phytocannabinoid. It is an aromatic compound that has been isolated from Lebanese hashish.{30516} The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications. This item has been tested to contain ≤0.3% Δ9-THC on a dry weight basis meeting the 2018 Farm Bill requirements to be a non-controlled substance in the U.S.  

     

    Brand:
    Cayman
    SKU:9002479 - 1 mg

    Available on backorder

  • Cannabinodiol (Item No. 9002479) is an analytical reference standard that is categorized as a phytocannabinoid. It is an aromatic compound that has been isolated from Lebanese hashish.{30516} The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications. This item has been tested to contain ≤0.3% Δ9-THC on a dry weight basis meeting the 2018 Farm Bill requirements to be a non-controlled substance in the U.S.  

     

    Brand:
    Cayman
    SKU:9002479 - 10 mg

    Available on backorder

  • Cannabinodiol (Item No. 9002479) is an analytical reference standard that is categorized as a phytocannabinoid. It is an aromatic compound that has been isolated from Lebanese hashish.{30516} The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications. This item has been tested to contain ≤0.3% Δ9-THC on a dry weight basis meeting the 2018 Farm Bill requirements to be a non-controlled substance in the U.S.  

     

    Brand:
    Cayman
    SKU:9002479 - 5 mg

    Available on backorder

  • Cannabinol (Item No. 25495) is an analytical reference standard categorized as a phytocannabinoid.{27531} This product is intended for research and forensic applications. This item has been tested to contain ≤0.3% Δ9-THC on a dry weight basis meeting the 2018 Farm Bill requirements to be a non-controlled substance in the US.  

     

    Brand:
    Cayman
    SKU:25495 - 10 mg

    Available on backorder

  • Cannabinol (Item No. 25495) is an analytical reference standard categorized as a phytocannabinoid.{27531} This product is intended for research and forensic applications. This item has been tested to contain ≤0.3% Δ9-THC on a dry weight basis meeting the 2018 Farm Bill requirements to be a non-controlled substance in the US.  

     

    Brand:
    Cayman
    SKU:25495 - 50 mg

    Available on backorder

  • Cannabinol monomethyl ether (Item No. 9002480) is an analytical reference standard that is categorized as a phytocannabinoid. It can be isolated from Cannabis plants, derived from cannabinol (Item No. ISO60183), or synthesized.{30521,30522,30523} The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:9002480 - 1 mg

    Available on backorder

  • Cannabinol monomethyl ether (Item No. 9002480) is an analytical reference standard that is categorized as a phytocannabinoid. It can be isolated from Cannabis plants, derived from cannabinol (Item No. ISO60183), or synthesized.{30521,30522,30523} The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:9002480 - 10 mg

    Available on backorder

  • Cannabinol monomethyl ether (Item No. 9002480) is an analytical reference standard that is categorized as a phytocannabinoid. It can be isolated from Cannabis plants, derived from cannabinol (Item No. ISO60183), or synthesized.{30521,30522,30523} The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:9002480 - 5 mg

    Available on backorder

  • Cannabivarin (Item No. 21664) is an analytical reference standard categorized as a phytocannabinoid.{38641} It is a constituent of hashish and has also been isolated from C. sativa plants.{38641,38642} Cannabivarin is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications. This item has been tested to contain ≤0.3% Δ9-THC on a dry weight basis meeting the 2018 Farm Bill requirements to be a non-controlled substance in the U.S.  

     

    Brand:
    Cayman
    SKU:21664 -

    Out of stock

  • Cannabivarin (Item No. 21664) is an analytical reference standard categorized as a phytocannabinoid.{38641} It is a constituent of hashish and has also been isolated from C. sativa plants.{38641,38642} Cannabivarin is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications. This item has been tested to contain ≤0.3% Δ9-THC on a dry weight basis meeting the 2018 Farm Bill requirements to be a non-controlled substance in the U.S.  

     

    Brand:
    Cayman
    SKU:21664 -

    Out of stock

  • Canrenone (Item No. 21307) is an analytical reference standard categorized as a steroid.{33132} It is an active metabolite of spironolactone (Item No. 9000324) that acts as a diuretic. Diuretics, including canrenone, have been abused as performance-enhancing drugs and masking agents in sports doping.{33139} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:21307 -

    Out of stock

  • Canrenone (Item No. 21307) is an analytical reference standard categorized as a steroid.{33132} It is an active metabolite of spironolactone (Item No. 9000324) that acts as a diuretic. Diuretics, including canrenone, have been abused as performance-enhancing drugs and masking agents in sports doping.{33139} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:21307 -

    Out of stock

  • Cantharidic acid is a hydrolysis product of cantharidin (Item No. 14589), an inhibitor of protein phosphatases first isolated from Chinese blister beetles.{21678} Cantharidic acid inhibits the protein phosphatases PP1 and PP2A with IC50 values of 0.6 and 0.05 µM, respectively, but does not affect PP2B or PP2C.{21678} Cantharidic acid is frequently used to study cellular processes that are regulated by reversible protein phosphorylation.  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Cantharidic acid is a hydrolysis product of cantharidin (Item No. 14589), an inhibitor of protein phosphatases first isolated from Chinese blister beetles.{21678} Cantharidic acid inhibits the protein phosphatases PP1 and PP2A with IC50 values of 0.6 and 0.05 µM, respectively, but does not affect PP2B or PP2C.{21678} Cantharidic acid is frequently used to study cellular processes that are regulated by reversible protein phosphorylation.  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Cantharidic acid is a hydrolysis product of cantharidin (Item No. 14589), an inhibitor of protein phosphatases first isolated from Chinese blister beetles.{21678} Cantharidic acid inhibits the protein phosphatases PP1 and PP2A with IC50 values of 0.6 and 0.05 µM, respectively, but does not affect PP2B or PP2C.{21678} Cantharidic acid is frequently used to study cellular processes that are regulated by reversible protein phosphorylation.  

     

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    Cayman
    SKU:-

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  • Cantharidic acid is a hydrolysis product of cantharidin (Item No. 14589), an inhibitor of protein phosphatases first isolated from Chinese blister beetles.{21678} Cantharidic acid inhibits the protein phosphatases PP1 and PP2A with IC50 values of 0.6 and 0.05 µM, respectively, but does not affect PP2B or PP2C.{21678} Cantharidic acid is frequently used to study cellular processes that are regulated by reversible protein phosphorylation.  

     

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    Cayman
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  • Cantharidin is a natural toxin produced by blister beetles that moderately inhibits protein phosphatases 1 (PP1) (IC50 = 1.7 μM) and PP2A (IC50 = 0.2 μM) and only weakly inhibits the activity of PP2B (IC50 = 1 mM).{23052,21678} It has been shown to stimulate cell cycle progression and induce premature mitosis, used topically (0.7%) as an anti-wart treatment, and has been shown to be active in cervical, tongue, neuroblastoma, bone, leukemia, ovarian, colon, and various other cancer cell lines.{21678}  

     

    Brand:
    Cayman
    SKU:-
  • Cantharidin is a natural toxin produced by blister beetles that moderately inhibits protein phosphatases 1 (PP1) (IC50 = 1.7 μM) and PP2A (IC50 = 0.2 μM) and only weakly inhibits the activity of PP2B (IC50 = 1 mM).{23052,21678} It has been shown to stimulate cell cycle progression and induce premature mitosis, used topically (0.7%) as an anti-wart treatment, and has been shown to be active in cervical, tongue, neuroblastoma, bone, leukemia, ovarian, colon, and various other cancer cell lines.{21678}  

     

    Brand:
    Cayman
    SKU:-
  • CAP 3 is a cholic acid-peptide conjugate (CAP) with antibacterial activity.{35740} It is active against the Gram-negative bacteria E. coli, K. pneumoniae, and A. baumanii (MIC99s = 8, 16, and 16 μM, respectively). CAP 3 increases the fluidity of model Gram-negative bacterial membranes and binds to LPS in vitro. It reduces the biomass and number of colony-forming units in E. coli biofilms in a concentration-dependent manner. CAP 3 inhibits E. coli biofilm formation on catheters implanted in mice infected with E. coli at the incision site when applied as a coating on the catheters. CAP 3 (40 mg/kg) also reduces bacterial load in E. coli-infected wounds in mice. It is cytotoxic to A459 cells (IC50 = 56.4 μM) and has hemolytic activity against human red blood cells with a 50% lysis (HC50) value of 48 μM.  

     

    Brand:
    Cayman
    SKU:27505 - 1 mg

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  • CAP 3 is a cholic acid-peptide conjugate (CAP) with antibacterial activity.{35740} It is active against the Gram-negative bacteria E. coli, K. pneumoniae, and A. baumanii (MIC99s = 8, 16, and 16 μM, respectively). CAP 3 increases the fluidity of model Gram-negative bacterial membranes and binds to LPS in vitro. It reduces the biomass and number of colony-forming units in E. coli biofilms in a concentration-dependent manner. CAP 3 inhibits E. coli biofilm formation on catheters implanted in mice infected with E. coli at the incision site when applied as a coating on the catheters. CAP 3 (40 mg/kg) also reduces bacterial load in E. coli-infected wounds in mice. It is cytotoxic to A459 cells (IC50 = 56.4 μM) and has hemolytic activity against human red blood cells with a 50% lysis (HC50) value of 48 μM.  

     

    Brand:
    Cayman
    SKU:27505 - 10 mg

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  • CAP 3 is a cholic acid-peptide conjugate (CAP) with antibacterial activity.{35740} It is active against the Gram-negative bacteria E. coli, K. pneumoniae, and A. baumanii (MIC99s = 8, 16, and 16 μM, respectively). CAP 3 increases the fluidity of model Gram-negative bacterial membranes and binds to LPS in vitro. It reduces the biomass and number of colony-forming units in E. coli biofilms in a concentration-dependent manner. CAP 3 inhibits E. coli biofilm formation on catheters implanted in mice infected with E. coli at the incision site when applied as a coating on the catheters. CAP 3 (40 mg/kg) also reduces bacterial load in E. coli-infected wounds in mice. It is cytotoxic to A459 cells (IC50 = 56.4 μM) and has hemolytic activity against human red blood cells with a 50% lysis (HC50) value of 48 μM.  

     

    Brand:
    Cayman
    SKU:27505 - 5 mg

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  • Capadenoson is an orally bioavailable, non-nucleoside adenosine (A) receptor partial agonist.{45534,45535} It binds selectively to human A1 and A2B (EC50s = 0.66 and 1.1 nM, respectively) over A2A and A3 receptors (EC50s = 1,413 and 240 nM, respectively) expressed in CHO cells.{45534} Capadenoson (0.6 μM) decreases electrical field-stimulated norepinephrine (Item No. 16673) release from isolated perfused hearts from spontaneously hypertensive rats (SHR) but not from control rats.{50106} It does not affect baseline heart rate but protects against stress-induced increases in heart rate in SHR but not control rats when administered at a dose of 0.15 mg/kg for 5 days prior to stress induction. Capadenoson (0.1 mg/kg) decreases cardiac infarct size from 28.7 to 22% in a mouse model of ischemia induced by left anterior descending artery (LAD) occlusion.{45535} Capadenoson (7.5 mg twice per day) also increases the left ventricular ejection fraction (LVEF) in a dog model of microembolization-induced heart failure.{45536}  

     

    Brand:
    Cayman
    SKU:28422 - 1 mg

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  • Capadenoson is an orally bioavailable, non-nucleoside adenosine (A) receptor partial agonist.{45534,45535} It binds selectively to human A1 and A2B (EC50s = 0.66 and 1.1 nM, respectively) over A2A and A3 receptors (EC50s = 1,413 and 240 nM, respectively) expressed in CHO cells.{45534} Capadenoson (0.6 μM) decreases electrical field-stimulated norepinephrine (Item No. 16673) release from isolated perfused hearts from spontaneously hypertensive rats (SHR) but not from control rats.{50106} It does not affect baseline heart rate but protects against stress-induced increases in heart rate in SHR but not control rats when administered at a dose of 0.15 mg/kg for 5 days prior to stress induction. Capadenoson (0.1 mg/kg) decreases cardiac infarct size from 28.7 to 22% in a mouse model of ischemia induced by left anterior descending artery (LAD) occlusion.{45535} Capadenoson (7.5 mg twice per day) also increases the left ventricular ejection fraction (LVEF) in a dog model of microembolization-induced heart failure.{45536}  

     

    Brand:
    Cayman
    SKU:28422 - 10 mg

    Available on backorder

  • Capadenoson is an orally bioavailable, non-nucleoside adenosine (A) receptor partial agonist.{45534,45535} It binds selectively to human A1 and A2B (EC50s = 0.66 and 1.1 nM, respectively) over A2A and A3 receptors (EC50s = 1,413 and 240 nM, respectively) expressed in CHO cells.{45534} Capadenoson (0.6 μM) decreases electrical field-stimulated norepinephrine (Item No. 16673) release from isolated perfused hearts from spontaneously hypertensive rats (SHR) but not from control rats.{50106} It does not affect baseline heart rate but protects against stress-induced increases in heart rate in SHR but not control rats when administered at a dose of 0.15 mg/kg for 5 days prior to stress induction. Capadenoson (0.1 mg/kg) decreases cardiac infarct size from 28.7 to 22% in a mouse model of ischemia induced by left anterior descending artery (LAD) occlusion.{45535} Capadenoson (7.5 mg twice per day) also increases the left ventricular ejection fraction (LVEF) in a dog model of microembolization-induced heart failure.{45536}  

     

    Brand:
    Cayman
    SKU:28422 - 5 mg

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  • Capecitabine is a prodrug of 5-fluorouracil (5-FU; Item No. 14416).{18418} It is converted to 5-FU via several enzymatic steps beginning in the liver and ending with conversion in tumor tissue by thymidine phosphorylase, an enzyme that is more concentrated in tumor tissue compared with normal tissue. Capecitabine is cytotoxic only at high concentrations in Scaber, SIHA, and MKN45 cells (IC50s = 97, 578, and 994 µM, respectively) and is inactive in a variety of cancer cell lines, including COLO205, HCT116, and MCF-7 cells (IC50s = >1,000 µM).  

     

    Brand:
    Cayman
    SKU:10487 - 1 g

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  • Capecitabine is a prodrug of 5-fluorouracil (5-FU; Item No. 14416).{18418} It is converted to 5-FU via several enzymatic steps beginning in the liver and ending with conversion in tumor tissue by thymidine phosphorylase, an enzyme that is more concentrated in tumor tissue compared with normal tissue. Capecitabine is cytotoxic only at high concentrations in Scaber, SIHA, and MKN45 cells (IC50s = 97, 578, and 994 µM, respectively) and is inactive in a variety of cancer cell lines, including COLO205, HCT116, and MCF-7 cells (IC50s = >1,000 µM).  

     

    Brand:
    Cayman
    SKU:10487 - 5 g

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  • Capecitabine is a prodrug of 5-fluorouracil (5-FU; Item No. 14416).{18418} It is converted to 5-FU via several enzymatic steps beginning in the liver and ending with conversion in tumor tissue by thymidine phosphorylase, an enzyme that is more concentrated in tumor tissue compared with normal tissue. Capecitabine is cytotoxic only at high concentrations in Scaber, SIHA, and MKN45 cells (IC50s = 97, 578, and 994 µM, respectively) and is inactive in a variety of cancer cell lines, including COLO205, HCT116, and MCF-7 cells (IC50s = >1,000 µM).  

     

    Brand:
    Cayman
    SKU:10487 - 500 mg

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  • Capecitabine-d11 is intended for use as an internal standard for the quantification of capecitabine (Item No. 10487) by GC- or LC-MS. Capecitabine is a prodrug form of 5-fluorouracil (5-FU; Item No. 14416).{18418} It is converted to 5-FU via several enzymatic steps beginning in the liver and ending with conversion in tumor tissue by thymidine phosphorylase, an enzyme that is more concentrated in tumor tissue compared with normal tissue. Capecitabine is cytotoxic only at high concentrations in Scaber, SIHA, and MKN45 cells (IC50s = 97, 578, and 994 µM, respectively) and is inactive in a variety of cancer cell lines, including COLO 205, HCT116, and MCF-7 cells (IC50s = >1,000 µM).  

     

    Brand:
    Cayman
    SKU:10010681 - 1 mg

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  • Capecitabine-d11 is intended for use as an internal standard for the quantification of capecitabine (Item No. 10487) by GC- or LC-MS. Capecitabine is a prodrug form of 5-fluorouracil (5-FU; Item No. 14416).{18418} It is converted to 5-FU via several enzymatic steps beginning in the liver and ending with conversion in tumor tissue by thymidine phosphorylase, an enzyme that is more concentrated in tumor tissue compared with normal tissue. Capecitabine is cytotoxic only at high concentrations in Scaber, SIHA, and MKN45 cells (IC50s = 97, 578, and 994 µM, respectively) and is inactive in a variety of cancer cell lines, including COLO 205, HCT116, and MCF-7 cells (IC50s = >1,000 µM).  

     

    Brand:
    Cayman
    SKU:10010681 - 5 mg

    Available on backorder

  • Capreomycin is a polypeptide antibiotic first isolated from S. capreolus.{32372} It is cytotoxic to M. tuberculosis (MIC = 10 µg/ml).{32372} Capreomycin is more effective against M. tuberculosis when combined with aminoglycoside antibiotics.  

     

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    Cayman
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  • Capreomycin is a polypeptide antibiotic first isolated from S. capreolus.{32372} It is cytotoxic to M. tuberculosis (MIC = 10 µg/ml).{32372} Capreomycin is more effective against M. tuberculosis when combined with aminoglycoside antibiotics.  

     

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    Cayman
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  • Capreomycin is a polypeptide antibiotic first isolated from S. capreolus.{32372} It is cytotoxic to M. tuberculosis (MIC = 10 µg/ml).{32372} Capreomycin is more effective against M. tuberculosis when combined with aminoglycoside antibiotics.  

     

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    Cayman
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  • Caprooyl tetrapeptide-3 is a derivative of tetrapeptide-3 that is linked to caproic acid.{51219} It has migration-imparting effects in human adipose-derived stem cells when applied at concentrations of 0.1 and 1 mg/ml.  

     

    Brand:
    Cayman
    SKU:27154 - 10 mg

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  • Caprooyl tetrapeptide-3 is a derivative of tetrapeptide-3 that is linked to caproic acid.{51219} It has migration-imparting effects in human adipose-derived stem cells when applied at concentrations of 0.1 and 1 mg/ml.  

     

    Brand:
    Cayman
    SKU:27154 - 100 mg

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  • Caprooyl tetrapeptide-3 is a derivative of tetrapeptide-3 that is linked to caproic acid.{51219} It has migration-imparting effects in human adipose-derived stem cells when applied at concentrations of 0.1 and 1 mg/ml.  

     

    Brand:
    Cayman
    SKU:27154 - 25 mg

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  • Caprooyl tetrapeptide-3 is a derivative of tetrapeptide-3 that is linked to caproic acid.{51219} It has migration-imparting effects in human adipose-derived stem cells when applied at concentrations of 0.1 and 1 mg/ml.  

     

    Brand:
    Cayman
    SKU:27154 - 50 mg

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  • Capsaicin is a terpene alkaloid that has been found in Capsicum and has diverse biological activities.{55276,55277,55278,55279} It induces inward currents in HEK293 cells expressing rat transient receptor potential vanilloid 1 (TRPV1; EC50 = 0.64 µM at neutral pH), an effect that can be blocked by the TRPV1 inhibitor A-425619.{55276} Capsaicin (10 and 50 µM) decreases LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production, as well as reduces LPS- and IFN-induced nitric oxide (NO) release in isolated mouse peritoneal macrophages.{55277} Capsaicin induces substance P release in rat spinal cord slices with an EC50 value of 2.3 µM.{55278} It reduces acetylcholine- or phenylquinone-induced writhing (ED50s = 1.33 and 1.38 mg/kg, respectively, s.c.) but has no effect on the latency to paw withdrawal in the hot plate test in mice (ED50 = >20 mg/kg, s.c.).{55279} Formulations containing capsaicin have been used in the treatment of nerve pain associated with shingles.  

     

    Brand:
    Cayman
    SKU:92350 - 1 g

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  • Capsaicin is a terpene alkaloid that has been found in Capsicum and has diverse biological activities.{55276,55277,55278,55279} It induces inward currents in HEK293 cells expressing rat transient receptor potential vanilloid 1 (TRPV1; EC50 = 0.64 µM at neutral pH), an effect that can be blocked by the TRPV1 inhibitor A-425619.{55276} Capsaicin (10 and 50 µM) decreases LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production, as well as reduces LPS- and IFN-induced nitric oxide (NO) release in isolated mouse peritoneal macrophages.{55277} Capsaicin induces substance P release in rat spinal cord slices with an EC50 value of 2.3 µM.{55278} It reduces acetylcholine- or phenylquinone-induced writhing (ED50s = 1.33 and 1.38 mg/kg, respectively, s.c.) but has no effect on the latency to paw withdrawal in the hot plate test in mice (ED50 = >20 mg/kg, s.c.).{55279} Formulations containing capsaicin have been used in the treatment of nerve pain associated with shingles.  

     

    Brand:
    Cayman
    SKU:92350 - 100 mg

    Available on backorder

  • Capsaicin is a terpene alkaloid that has been found in Capsicum and has diverse biological activities.{55276,55277,55278,55279} It induces inward currents in HEK293 cells expressing rat transient receptor potential vanilloid 1 (TRPV1; EC50 = 0.64 µM at neutral pH), an effect that can be blocked by the TRPV1 inhibitor A-425619.{55276} Capsaicin (10 and 50 µM) decreases LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production, as well as reduces LPS- and IFN-induced nitric oxide (NO) release in isolated mouse peritoneal macrophages.{55277} Capsaicin induces substance P release in rat spinal cord slices with an EC50 value of 2.3 µM.{55278} It reduces acetylcholine- or phenylquinone-induced writhing (ED50s = 1.33 and 1.38 mg/kg, respectively, s.c.) but has no effect on the latency to paw withdrawal in the hot plate test in mice (ED50 = >20 mg/kg, s.c.).{55279} Formulations containing capsaicin have been used in the treatment of nerve pain associated with shingles.  

     

    Brand:
    Cayman
    SKU:92350 - 250 mg

    Available on backorder

  • Capsaicin is a terpene alkaloid that has been found in Capsicum and has diverse biological activities.{55276,55277,55278,55279} It induces inward currents in HEK293 cells expressing rat transient receptor potential vanilloid 1 (TRPV1; EC50 = 0.64 µM at neutral pH), an effect that can be blocked by the TRPV1 inhibitor A-425619.{55276} Capsaicin (10 and 50 µM) decreases LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production, as well as reduces LPS- and IFN-induced nitric oxide (NO) release in isolated mouse peritoneal macrophages.{55277} Capsaicin induces substance P release in rat spinal cord slices with an EC50 value of 2.3 µM.{55278} It reduces acetylcholine- or phenylquinone-induced writhing (ED50s = 1.33 and 1.38 mg/kg, respectively, s.c.) but has no effect on the latency to paw withdrawal in the hot plate test in mice (ED50 = >20 mg/kg, s.c.).{55279} Formulations containing capsaicin have been used in the treatment of nerve pain associated with shingles.  

     

    Brand:
    Cayman
    SKU:92350 - 500 mg

    Available on backorder

  • Capsaicin is a terpene alkaloid that has been found in Capsicum and has diverse biological activities.{55276,55277,55278,55279} It induces inward currents in HEK293 cells expressing rat transient receptor potential vanilloid 1 (TRPV1; EC50 = 0.64 µM at neutral pH), an effect that can be blocked by the TRPV1 inhibitor A-425619.{55276} Capsaicin (10 and 50 µM) decreases LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production, as well as reduces LPS- and IFN-induced nitric oxide (NO) release in isolated mouse peritoneal macrophages.{55277} Capsaicin induces substance P release in rat spinal cord slices with an EC50 value of 2.3 µM.{55278} It reduces acetylcholine- or phenylquinone-induced writhing (ED50s = 1.33 and 1.38 mg/kg, respectively, s.c.) but has no effect on the latency to paw withdrawal in the hot plate test in mice (ED50 = >20 mg/kg, s.c.).{55279} Formulations containing capsaicin have been used in the treatment of nerve pain associated with shingles.  

     

    Brand:
    Cayman
    SKU:10010743 - 1 g

    Available on backorder

  • Capsaicin is a terpene alkaloid that has been found in Capsicum and has diverse biological activities.{55276,55277,55278,55279} It induces inward currents in HEK293 cells expressing rat transient receptor potential vanilloid 1 (TRPV1; EC50 = 0.64 µM at neutral pH), an effect that can be blocked by the TRPV1 inhibitor A-425619.{55276} Capsaicin (10 and 50 µM) decreases LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production, as well as reduces LPS- and IFN-induced nitric oxide (NO) release in isolated mouse peritoneal macrophages.{55277} Capsaicin induces substance P release in rat spinal cord slices with an EC50 value of 2.3 µM.{55278} It reduces acetylcholine- or phenylquinone-induced writhing (ED50s = 1.33 and 1.38 mg/kg, respectively, s.c.) but has no effect on the latency to paw withdrawal in the hot plate test in mice (ED50 = >20 mg/kg, s.c.).{55279} Formulations containing capsaicin have been used in the treatment of nerve pain associated with shingles.  

     

    Brand:
    Cayman
    SKU:10010743 - 10 g

    Available on backorder

  • Capsaicin is a terpene alkaloid that has been found in Capsicum and has diverse biological activities.{55276,55277,55278,55279} It induces inward currents in HEK293 cells expressing rat transient receptor potential vanilloid 1 (TRPV1; EC50 = 0.64 µM at neutral pH), an effect that can be blocked by the TRPV1 inhibitor A-425619.{55276} Capsaicin (10 and 50 µM) decreases LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production, as well as reduces LPS- and IFN-induced nitric oxide (NO) release in isolated mouse peritoneal macrophages.{55277} Capsaicin induces substance P release in rat spinal cord slices with an EC50 value of 2.3 µM.{55278} It reduces acetylcholine- or phenylquinone-induced writhing (ED50s = 1.33 and 1.38 mg/kg, respectively, s.c.) but has no effect on the latency to paw withdrawal in the hot plate test in mice (ED50 = >20 mg/kg, s.c.).{55279} Formulations containing capsaicin have been used in the treatment of nerve pain associated with shingles.  

     

    Brand:
    Cayman
    SKU:10010743 - 5 g

    Available on backorder

  • Capsaicin is a terpene alkaloid that has been found in Capsicum and has diverse biological activities.{55276,55277,55278,55279} It induces inward currents in HEK293 cells expressing rat transient receptor potential vanilloid 1 (TRPV1; EC50 = 0.64 µM at neutral pH), an effect that can be blocked by the TRPV1 inhibitor A-425619.{55276} Capsaicin (10 and 50 µM) decreases LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production, as well as reduces LPS- and IFN-induced nitric oxide (NO) release in isolated mouse peritoneal macrophages.{55277} Capsaicin induces substance P release in rat spinal cord slices with an EC50 value of 2.3 µM.{55278} It reduces acetylcholine- or phenylquinone-induced writhing (ED50s = 1.33 and 1.38 mg/kg, respectively, s.c.) but has no effect on the latency to paw withdrawal in the hot plate test in mice (ED50 = >20 mg/kg, s.c.).{55279} Formulations containing capsaicin have been used in the treatment of nerve pain associated with shingles.  

     

    Brand:
    Cayman
    SKU:10010743 - 500 mg

    Available on backorder

  • Capsanthin is a carotenoid that has been found in C. annuum and has diverse biological activities.{46052,46053,46054} It reduces hydrogen peroxide-induced production of reactive oxygen species (ROS) and phosphorylation of ERK and p38 and prevents hydrogen peroxide-induced inhibition of gap junction intercellular communication in WB-F344 rat liver epithelial cells.{46052} Capsanthin (0.2 mg/animal) reduces the number of colonic aberrant crypt foci and preneoplastic lesions in a rat model of N-methylnitrosourea-induced colon carcinogenesis.{46053} It also reduces ear edema in a mouse model of inflammation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014).{46054}  

     

    Brand:
    Cayman
    SKU:31202 - 1 mg

    Available on backorder

  • Capsanthin is a carotenoid that has been found in C. annuum and has diverse biological activities.{46052,46053,46054} It reduces hydrogen peroxide-induced production of reactive oxygen species (ROS) and phosphorylation of ERK and p38 and prevents hydrogen peroxide-induced inhibition of gap junction intercellular communication in WB-F344 rat liver epithelial cells.{46052} Capsanthin (0.2 mg/animal) reduces the number of colonic aberrant crypt foci and preneoplastic lesions in a rat model of N-methylnitrosourea-induced colon carcinogenesis.{46053} It also reduces ear edema in a mouse model of inflammation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014).{46054}  

     

    Brand:
    Cayman
    SKU:31202 - 500 µg

    Available on backorder

  • Transient receptor potential vanilloid type 1 (TRPV1) is a member of the transient receptor potential (TRP) family that is activated or sensitized by a variety of endogenous stimuli as a result of tissue injury and inflammation. TRPV1 is upregulated during inflammation and plays a role in the perception of pain.{13323,14052} Capsazepine is a competitive antagonist of transient receptor potential vanilloid type 1 (TRPV1) which blocks the capsaicin-induced uptake of Ca2+ in neonatal rat dorsal root ganglia with an IC50 of 0.42 µM and Chinese hamster ovary cells with an IC50 of 17 nM.{13323,14051} It does not block acid- or heat-induced activation of TRPV1 and may block receptors other than TRPV1.{14053,14054}  

     

    Brand:
    Cayman
    SKU:10007518 - 1 mg

    Available on backorder

  • Transient receptor potential vanilloid type 1 (TRPV1) is a member of the transient receptor potential (TRP) family that is activated or sensitized by a variety of endogenous stimuli as a result of tissue injury and inflammation. TRPV1 is upregulated during inflammation and plays a role in the perception of pain.{13323,14052} Capsazepine is a competitive antagonist of transient receptor potential vanilloid type 1 (TRPV1) which blocks the capsaicin-induced uptake of Ca2+ in neonatal rat dorsal root ganglia with an IC50 of 0.42 µM and Chinese hamster ovary cells with an IC50 of 17 nM.{13323,14051} It does not block acid- or heat-induced activation of TRPV1 and may block receptors other than TRPV1.{14053,14054}  

     

    Brand:
    Cayman
    SKU:10007518 - 10 mg

    Available on backorder

  • Transient receptor potential vanilloid type 1 (TRPV1) is a member of the transient receptor potential (TRP) family that is activated or sensitized by a variety of endogenous stimuli as a result of tissue injury and inflammation. TRPV1 is upregulated during inflammation and plays a role in the perception of pain.{13323,14052} Capsazepine is a competitive antagonist of transient receptor potential vanilloid type 1 (TRPV1) which blocks the capsaicin-induced uptake of Ca2+ in neonatal rat dorsal root ganglia with an IC50 of 0.42 µM and Chinese hamster ovary cells with an IC50 of 17 nM.{13323,14051} It does not block acid- or heat-induced activation of TRPV1 and may block receptors other than TRPV1.{14053,14054}  

     

    Brand:
    Cayman
    SKU:10007518 - 5 mg

    Available on backorder

  • Transient receptor potential vanilloid type 1 (TRPV1) is a member of the transient receptor potential (TRP) family that is activated or sensitized by a variety of endogenous stimuli as a result of tissue injury and inflammation. TRPV1 is upregulated during inflammation and plays a role in the perception of pain.{13323,14052} Capsazepine is a competitive antagonist of transient receptor potential vanilloid type 1 (TRPV1) which blocks the capsaicin-induced uptake of Ca2+ in neonatal rat dorsal root ganglia with an IC50 of 0.42 µM and Chinese hamster ovary cells with an IC50 of 17 nM.{13323,14051} It does not block acid- or heat-induced activation of TRPV1 and may block receptors other than TRPV1.{14053,14054}  

     

    Brand:
    Cayman
    SKU:10007518 - 50 mg

    Available on backorder

  • Capsiconiate is a coniferyl ester that has been isolated from certain plants in the Solanaceae family, including plants in the genus Capsicum.{29501} It is structurally related to capsaicin (Item No. 92350), the primary heat- and pain-eliciting compound from the Capsicum pepper.{10293} Like capsaicin, capsiconiate is an agonist of the transient receptor potential vanilloid receptor TRPV1 (EC50 = 3.2 µM).{29501} However, the maximum response induced by capsiconiate through TRPV1 is only 20% of that of capsaicin, indicating that it’s a partial agonist of TRPV1.{29501}  

     

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    Cayman
    SKU:-

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  • Capsiconiate is a coniferyl ester that has been isolated from certain plants in the Solanaceae family, including plants in the genus Capsicum.{29501} It is structurally related to capsaicin (Item No. 92350), the primary heat- and pain-eliciting compound from the Capsicum pepper.{10293} Like capsaicin, capsiconiate is an agonist of the transient receptor potential vanilloid receptor TRPV1 (EC50 = 3.2 µM).{29501} However, the maximum response induced by capsiconiate through TRPV1 is only 20% of that of capsaicin, indicating that it’s a partial agonist of TRPV1.{29501}  

     

    Brand:
    Cayman
    SKU:-

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  • Capsiconiate is a coniferyl ester that has been isolated from certain plants in the Solanaceae family, including plants in the genus Capsicum.{29501} It is structurally related to capsaicin (Item No. 92350), the primary heat- and pain-eliciting compound from the Capsicum pepper.{10293} Like capsaicin, capsiconiate is an agonist of the transient receptor potential vanilloid receptor TRPV1 (EC50 = 3.2 µM).{29501} However, the maximum response induced by capsiconiate through TRPV1 is only 20% of that of capsaicin, indicating that it’s a partial agonist of TRPV1.{29501}  

     

    Brand:
    Cayman
    SKU:-

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  • Capsiconiate is a coniferyl ester that has been isolated from certain plants in the Solanaceae family, including plants in the genus Capsicum.{29501} It is structurally related to capsaicin (Item No. 92350), the primary heat- and pain-eliciting compound from the Capsicum pepper.{10293} Like capsaicin, capsiconiate is an agonist of the transient receptor potential vanilloid receptor TRPV1 (EC50 = 3.2 µM).{29501} However, the maximum response induced by capsiconiate through TRPV1 is only 20% of that of capsaicin, indicating that it’s a partial agonist of TRPV1.{29501}  

     

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    Cayman
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  • Captan is a trichloromethyl sulfenyl fungicide that degrades into thiophosgene, a highly reactive compound that reacts with thiol and non-thiol proteins, in cells.{42163} It reduces radial growth of and starch depletion by A. fumigatus on the leaf surface of A. tenuis when used at a concentration of 50 μg/ml.{42164} Captan (50-1,000 mg/kg) increases the number of micronuclei and chromosomal aberrations in polychromatic erythrocytes in bone marrow in mice.{42165} It also induces chromosomal aberrations in spermatocytes and sperm head abnormalities in mice. Captan reduces survival of adult male and female alfalfa leafcutting bees (M. rotunda) when applied topically or administered in the diet at concentrations of 150-684 and 24.45-48.9 g/L, respectively.{42166}  

     

    Brand:
    Cayman
    SKU:24138 - 100 mg

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  • Captan is a trichloromethyl sulfenyl fungicide that degrades into thiophosgene, a highly reactive compound that reacts with thiol and non-thiol proteins, in cells.{42163} It reduces radial growth of and starch depletion by A. fumigatus on the leaf surface of A. tenuis when used at a concentration of 50 μg/ml.{42164} Captan (50-1,000 mg/kg) increases the number of micronuclei and chromosomal aberrations in polychromatic erythrocytes in bone marrow in mice.{42165} It also induces chromosomal aberrations in spermatocytes and sperm head abnormalities in mice. Captan reduces survival of adult male and female alfalfa leafcutting bees (M. rotunda) when applied topically or administered in the diet at concentrations of 150-684 and 24.45-48.9 g/L, respectively.{42166}  

     

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    Cayman
    SKU:24138 - 50 mg

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  • Captopril is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 23 nM for the rabbit lung enzyme).{42208,52244} It inhibits contractions in isolated guinea pig ileal segments induced by angiotensin I or bradykinin (IC50s = 23 and 3 nM, respectively) but not those induced by angiotensin II, histamine, acetylcholine, serotonin (5-HT), or prostaglandin E1 (PGE1; IC50s = >10 µM for all).{52244} Captopril (0.1-1 mg/kg) inhibits angiotensin I-induced pressor responses in conscious normotensive rats.{42208} It reduces mean blood pressure in two kidney-one clip renal hypertensive (2K-1C) rats and spontaneously hypertensive rats (SHRs). Captopril also reduces cytopathogenicity induced by herpes simplex virus 1 (HSV-1) in SH-SY5Y human neuroblastoma cells.{61145} Formulations containing captopril have been used in the treatment of hypertension, congestive heart failure, and diabetic nephropathy.  

     

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    Cayman
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  • Captopril is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 23 nM for the rabbit lung enzyme).{42208,52244} It inhibits contractions in isolated guinea pig ileal segments induced by angiotensin I or bradykinin (IC50s = 23 and 3 nM, respectively) but not those induced by angiotensin II, histamine, acetylcholine, serotonin (5-HT), or prostaglandin E1 (PGE1; IC50s = >10 µM for all).{52244} Captopril (0.1-1 mg/kg) inhibits angiotensin I-induced pressor responses in conscious normotensive rats.{42208} It reduces mean blood pressure in two kidney-one clip renal hypertensive (2K-1C) rats and spontaneously hypertensive rats (SHRs). Captopril also reduces cytopathogenicity induced by herpes simplex virus 1 (HSV-1) in SH-SY5Y human neuroblastoma cells.{61145} Formulations containing captopril have been used in the treatment of hypertension, congestive heart failure, and diabetic nephropathy.  

     

    Brand:
    Cayman
    SKU:-
  • Captopril is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 23 nM for the rabbit lung enzyme).{42208,52244} It inhibits contractions in isolated guinea pig ileal segments induced by angiotensin I or bradykinin (IC50s = 23 and 3 nM, respectively) but not those induced by angiotensin II, histamine, acetylcholine, serotonin (5-HT), or prostaglandin E1 (PGE1; IC50s = >10 µM for all).{52244} Captopril (0.1-1 mg/kg) inhibits angiotensin I-induced pressor responses in conscious normotensive rats.{42208} It reduces mean blood pressure in two kidney-one clip renal hypertensive (2K-1C) rats and spontaneously hypertensive rats (SHRs). Captopril also reduces cytopathogenicity induced by herpes simplex virus 1 (HSV-1) in SH-SY5Y human neuroblastoma cells.{61145} Formulations containing captopril have been used in the treatment of hypertension, congestive heart failure, and diabetic nephropathy.  

     

    Brand:
    Cayman
    SKU:-
  • Captopril is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 23 nM for the rabbit lung enzyme).{42208,52244} It inhibits contractions in isolated guinea pig ileal segments induced by angiotensin I or bradykinin (IC50s = 23 and 3 nM, respectively) but not those induced by angiotensin II, histamine, acetylcholine, serotonin (5-HT), or prostaglandin E1 (PGE1; IC50s = >10 µM for all).{52244} Captopril (0.1-1 mg/kg) inhibits angiotensin I-induced pressor responses in conscious normotensive rats.{42208} It reduces mean blood pressure in two kidney-one clip renal hypertensive (2K-1C) rats and spontaneously hypertensive rats (SHRs). Captopril also reduces cytopathogenicity induced by herpes simplex virus 1 (HSV-1) in SH-SY5Y human neuroblastoma cells.{61145} Formulations containing captopril have been used in the treatment of hypertension, congestive heart failure, and diabetic nephropathy.  

     

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    Cayman
    SKU:-
  • Captopril disulfide is a metabolite and symmetrical disulfide form of the angiotensin converting enzyme (ACE) inhibitor captopril (Item No. 15313).{47405} Captopril disulfide is the main degradation product of captopril and is formed by oxidation.{47406} It is a potential impurity in commercial preparations of captopril. Captopril disulfide inhibits angiotensin I-induced increases in mean arterial pressure in anesthetized dogs (ID50 = 0.231 mg/kg, i.v.).{47407}  

     

    Brand:
    Cayman
    SKU:28018 - 10 mg

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  • Captopril disulfide is a metabolite and symmetrical disulfide form of the angiotensin converting enzyme (ACE) inhibitor captopril (Item No. 15313).{47405} Captopril disulfide is the main degradation product of captopril and is formed by oxidation.{47406} It is a potential impurity in commercial preparations of captopril. Captopril disulfide inhibits angiotensin I-induced increases in mean arterial pressure in anesthetized dogs (ID50 = 0.231 mg/kg, i.v.).{47407}  

     

    Brand:
    Cayman
    SKU:28018 - 25 mg

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  • Captopril disulfide is a metabolite and symmetrical disulfide form of the angiotensin converting enzyme (ACE) inhibitor captopril (Item No. 15313).{47405} Captopril disulfide is the main degradation product of captopril and is formed by oxidation.{47406} It is a potential impurity in commercial preparations of captopril. Captopril disulfide inhibits angiotensin I-induced increases in mean arterial pressure in anesthetized dogs (ID50 = 0.231 mg/kg, i.v.).{47407}  

     

    Brand:
    Cayman
    SKU:28018 - 5 mg

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  • Captopril-d3 is intended for use as an internal standard for the quantification of captopril (Item No. 15313) by GC- or LC-MS. Captopril is a first generation nonpeptidic ACE inhibitor (IC50 = 6.3 nM) that was designed based on bradykinin-potentiating peptides isolated from the venom of B. jararaca, a pit viper native to Brazil. {25198,25199,25197} It does not exhibit a domain preference for binding either the C- or N-terminal active sites of the somatic form of ACE.{25198} Acute and chronic administration of captopril reduces blood pressure in spontaneously hypertensive Wistar-Kyoto rats and does not induce hypotension in salt-repleted normotensive Wistar-Kyoto rats.{42208} Captopril is also a competitive and reversible inhibitor of leukotriene (LTA4) hydrolase, which results in the disruption of LTB4 synthesis with an IC50 value of 14 μM.{25196}  

     

    Brand:
    Cayman
    SKU:25235 - 100 µg

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  • Captopril-d3 is intended for use as an internal standard for the quantification of captopril (Item No. 15313) by GC- or LC-MS. Captopril is a first generation nonpeptidic ACE inhibitor (IC50 = 6.3 nM) that was designed based on bradykinin-potentiating peptides isolated from the venom of B. jararaca, a pit viper native to Brazil. {25198,25199,25197} It does not exhibit a domain preference for binding either the C- or N-terminal active sites of the somatic form of ACE.{25198} Acute and chronic administration of captopril reduces blood pressure in spontaneously hypertensive Wistar-Kyoto rats and does not induce hypotension in salt-repleted normotensive Wistar-Kyoto rats.{42208} Captopril is also a competitive and reversible inhibitor of leukotriene (LTA4) hydrolase, which results in the disruption of LTB4 synthesis with an IC50 value of 14 μM.{25196}  

     

    Brand:
    Cayman
    SKU:25235 - 250 µg

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  • Captopril-d3 is intended for use as an internal standard for the quantification of captopril (Item No. 15313) by GC- or LC-MS. Captopril is a first generation nonpeptidic ACE inhibitor (IC50 = 6.3 nM) that was designed based on bradykinin-potentiating peptides isolated from the venom of B. jararaca, a pit viper native to Brazil. {25198,25199,25197} It does not exhibit a domain preference for binding either the C- or N-terminal active sites of the somatic form of ACE.{25198} Acute and chronic administration of captopril reduces blood pressure in spontaneously hypertensive Wistar-Kyoto rats and does not induce hypotension in salt-repleted normotensive Wistar-Kyoto rats.{42208} Captopril is also a competitive and reversible inhibitor of leukotriene (LTA4) hydrolase, which results in the disruption of LTB4 synthesis with an IC50 value of 14 μM.{25196}  

     

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    Cayman
    SKU:25235 - 500 µg

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  • Carazolol is a high-affinity, lipophilic, non-selective ligand of the β-adrenergic receptors (Kis = 0.114 and 0.4 nM for β2- and β3-adrenoceptors, respectively).{30279,30277,30275} It acts as a receptor antagonist (beta blocker) or inverse agonist for β1 and β2 receptors but functions as an agonist at the β3-adrenergic receptor.{30277,30275,30278,30276}  

     

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    Cayman
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  • Carazolol is a high-affinity, lipophilic, non-selective ligand of the β-adrenergic receptors (Kis = 0.114 and 0.4 nM for β2- and β3-adrenoceptors, respectively).{30279,30277,30275} It acts as a receptor antagonist (beta blocker) or inverse agonist for β1 and β2 receptors but functions as an agonist at the β3-adrenergic receptor.{30277,30275,30278,30276}  

     

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    Cayman
    SKU:-

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  • Carazolol is a high-affinity, lipophilic, non-selective ligand of the β-adrenergic receptors (Kis = 0.114 and 0.4 nM for β2- and β3-adrenoceptors, respectively).{30279,30277,30275} It acts as a receptor antagonist (beta blocker) or inverse agonist for β1 and β2 receptors but functions as an agonist at the β3-adrenergic receptor.{30277,30275,30278,30276}  

     

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    Cayman
    SKU:-

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  • Carazolol is a high-affinity, lipophilic, non-selective ligand of the β-adrenergic receptors (Kis = 0.114 and 0.4 nM for β2- and β3-adrenoceptors, respectively).{30279,30277,30275} It acts as a receptor antagonist (beta blocker) or inverse agonist for β1 and β2 receptors but functions as an agonist at the β3-adrenergic receptor.{30277,30275,30278,30276}  

     

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    Cayman
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  • Carbamoylcholine, also known as carbachol, is an analog of acetylcholine that activates acetylcholine receptors (AChR). Carbamoylcholine is an agonist of both nicotinic (nAChR) and muscarinic (mAChR) receptors, with reported Ki values ranging from 10 to 10,000 nM for different receptors and different preparations.{27179,27173,27178,27174,27175} Carbamoylcholine (chloride) is used to study responses mediated by nAChR and mAChR, including smooth muscle contraction, gut motility, and neuronal signaling.{27180,27177,27176}  

     

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    Cayman
    SKU:-
  • Carbamoylcholine, also known as carbachol, is an analog of acetylcholine that activates acetylcholine receptors (AChR). Carbamoylcholine is an agonist of both nicotinic (nAChR) and muscarinic (mAChR) receptors, with reported Ki values ranging from 10 to 10,000 nM for different receptors and different preparations.{27179,27173,27178,27174,27175} Carbamoylcholine (chloride) is used to study responses mediated by nAChR and mAChR, including smooth muscle contraction, gut motility, and neuronal signaling.{27180,27177,27176}  

     

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    Cayman
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  • Alpha-1 antitrypsin is a serine protease inhibitor and member of the serpin superfamily.{36461} It has a five-stranded A β-sheet and a mobile reactive center loop that acts as a pseudosubstrate for various proteases. Alpha-1 antitrypsin binds to a protease, undergoes proteolytic cleavage, and forms a covalent linkage between a carboxyl group in the reactive loop and the serine hydroxyl of the protease active site, effectively inactivating the enzyme which is then cleared from circulation. The primary targets of alpha-1 antitrypsin are neutrophil elastase and proteinase 3, however, it also inhibits trypsin, kallikreins 7 and 14, and matriptase.{36460} Alpha-1 antitrypsin protects the lower respiratory tract from proteolytic destruction via inhibition of neutrophil elastase and reduced serum levels of alpha-1 antitrypsin have been linked to early-onset liver disease and emphysema.{36459} Alpha-1 antitrypsin is an acute-phase protein that reduces production of inflammatory cytokines, inhibits apoptosis, blocks leukocyte degranulation and migration, as well as suppresses NF-κB nuclear translocation in monocytes. It delays disease onset in mouse models of inflammatory disease, including collagen-induced arthritis and experimental autoimmune encephalomyelitis (EAE). Alpha-1 antitrypsin is subject to post-translational modifications such as glycosylation and carbamylation in vivo. Carbamylated alpha-1 antitrypsin has been found in synovial fluid samples from rheumatoid arthritis patients and is predicted to act as an autoantigen.{36462} Cayman’s Carbamylated Alpha-1 Antitrypsin (K359) Polyclonal Antibody can be used for Western blot applications. This antibody recognizes carbamylated alpha-1 antitrypsin at ~47 kDa from human samples.  

     

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    Cayman
    SKU:25340 - 500 µl

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  • Immunogen: Synthetic peptide surrounding homocitrulline 359 (335 of the mature enzyme) of human A1AT • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) Carbamylated A1AT (-) Non-carbamylated proteins • Application: WB • MW = ~47 kDa  

     

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    Cayman
    SKU:25340- 500 µl

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  • Immunogen: Synthetic peptide surrounding homocitrulline 359 (335 of the mature enzyme) of human A1AT • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) Carbamylated A1AT (-) Non-carbamylated proteins • Application: WB • MW = ~47 kDa  

     

    Brand:
    Cayman
    SKU:25340- 500 µl
  • Carbaprostacyclin is a stable analog of PGI2. When infused in rabbits or dogs, it inhibits ex vivo platelet aggregation, but the effect persists only 10 minutes after termination of the infusion. This implies rapid metabolic inactivation of carbaprostacyclin.{509} Carbaprostacyclin inhibits platelet aggregation with 10% of the molar potency exhibited by PGI2.{509,513} The ED50 of carbaprostacyclin for the in vitro inhibition of ADP-induced platelet aggregation in human PRP is 47 nM.{511} It was also shown to effect terminal differentiation of preadipose into adipose cells and enhance the expression of angiotensinogen and adipose fatty acid binding protein with an EC50 of about 0.5 µM.{4061}  

     

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    Cayman
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  • Carbaprostacyclin is a stable analog of PGI2. When infused in rabbits or dogs, it inhibits ex vivo platelet aggregation, but the effect persists only 10 minutes after termination of the infusion. This implies rapid metabolic inactivation of carbaprostacyclin.{509} Carbaprostacyclin inhibits platelet aggregation with 10% of the molar potency exhibited by PGI2.{509,513} The ED50 of carbaprostacyclin for the in vitro inhibition of ADP-induced platelet aggregation in human PRP is 47 nM.{511} It was also shown to effect terminal differentiation of preadipose into adipose cells and enhance the expression of angiotensinogen and adipose fatty acid binding protein with an EC50 of about 0.5 µM.{4061}  

     

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    Cayman
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  • Carbaprostacyclin is a stable analog of PGI2. When infused in rabbits or dogs, it inhibits ex vivo platelet aggregation, but the effect persists only 10 minutes after termination of the infusion. This implies rapid metabolic inactivation of carbaprostacyclin.{509} Carbaprostacyclin inhibits platelet aggregation with 10% of the molar potency exhibited by PGI2.{509,513} The ED50 of carbaprostacyclin for the in vitro inhibition of ADP-induced platelet aggregation in human PRP is 47 nM.{511} It was also shown to effect terminal differentiation of preadipose into adipose cells and enhance the expression of angiotensinogen and adipose fatty acid binding protein with an EC50 of about 0.5 µM.{4061}  

     

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    Cayman
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  • Carbaprostacyclin is a stable analog of prostacyclin (prostaglandin I2) which can activate the prostacyclin receptor or PPARδ.{4061,3321,18709} Carbaprostacyclin methyl ester is a more lipid soluble form of carbaprostacyclin. As a result, it may more readily enter cells to activate PPARδ. The biological activities of carbaprostacyclin methyl ester have not been studied.  

     

    Brand:
    Cayman
    SKU:9000183 - 1 mg

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