Cayman
Showing 12301–12450 of 45550 results
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BMS-3 is a potent inhibitor of activated LIM domain kinases LIMK1 and LIMK2 (IC50s = 5 and 6 nM, respectively).{32445} It is used to study the role of activated LIMK isoforms in the signaling of Rho family GTPases to cytoskeletal proteins, including cofilin and tubulin.{32443,32444,32446}
Brand:CaymanSKU:-Available on backorder
BMS-3 is a potent inhibitor of activated LIM domain kinases LIMK1 and LIMK2 (IC50s = 5 and 6 nM, respectively).{32445} It is used to study the role of activated LIMK isoforms in the signaling of Rho family GTPases to cytoskeletal proteins, including cofilin and tubulin.{32443,32444,32446}
Brand:CaymanSKU:-Available on backorder
BMS-5 is a potent inhibitor of activated LIM domain kinases LIMK1 and LIMK2 with IC50 values of 7 and 8 nM, respectively.{32445} LIMK1 and LIMK2 participate in signal pathways affecting actin dynamics by deactivating cofilin.{32443,32444} This compound can be used to study the role of activated LIMK isoforms in the signaling of Rho family GTPases to cytoskeletal proteins, including cofilin.
Brand:CaymanSKU:21072 -Out of stock
BMS-5 is a potent inhibitor of activated LIM domain kinases LIMK1 and LIMK2 with IC50 values of 7 and 8 nM, respectively.{32445} LIMK1 and LIMK2 participate in signal pathways affecting actin dynamics by deactivating cofilin.{32443,32444} This compound can be used to study the role of activated LIMK isoforms in the signaling of Rho family GTPases to cytoskeletal proteins, including cofilin.
Brand:CaymanSKU:21072 -Out of stock
BMS-5 is a potent inhibitor of activated LIM domain kinases LIMK1 and LIMK2 with IC50 values of 7 and 8 nM, respectively.{32445} LIMK1 and LIMK2 participate in signal pathways affecting actin dynamics by deactivating cofilin.{32443,32444} This compound can be used to study the role of activated LIMK isoforms in the signaling of Rho family GTPases to cytoskeletal proteins, including cofilin.
Brand:CaymanSKU:21072 -Out of stock
BMS-536924 is a dual inhibitor of insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IC50s = 100 and 73 nM, respectively).{29658} In this way, it blocks IGF-1R autophosphorylation and signaling through MEK1/2 and Akt, leading to G1 arrest and apoptosis in myeloblastic leukemia ML-1 cells. BMS-536924 reverses epithelial-to-mesenchymal transition in immortalized mammary epithelial MCF10A cells overexpressing constitutively activated IGF-1R and causes growth inhibition and polarization of breast cancer MCF-7 cells.{29655,29657} It also induces expression of cytochrome P450 3A4 isoform in primary hepatocytes.{29656}
Brand:CaymanSKU:- BMS-536924 is a dual inhibitor of insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IC50s = 100 and 73 nM, respectively).{29658} In this way, it blocks IGF-1R autophosphorylation and signaling through MEK1/2 and Akt, leading to G1 arrest and apoptosis in myeloblastic leukemia ML-1 cells. BMS-536924 reverses epithelial-to-mesenchymal transition in immortalized mammary epithelial MCF10A cells overexpressing constitutively activated IGF-1R and causes growth inhibition and polarization of breast cancer MCF-7 cells.{29655,29657} It also induces expression of cytochrome P450 3A4 isoform in primary hepatocytes.{29656}
Brand:CaymanSKU:- BMS-536924 is a dual inhibitor of insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IC50s = 100 and 73 nM, respectively).{29658} In this way, it blocks IGF-1R autophosphorylation and signaling through MEK1/2 and Akt, leading to G1 arrest and apoptosis in myeloblastic leukemia ML-1 cells. BMS-536924 reverses epithelial-to-mesenchymal transition in immortalized mammary epithelial MCF10A cells overexpressing constitutively activated IGF-1R and causes growth inhibition and polarization of breast cancer MCF-7 cells.{29655,29657} It also induces expression of cytochrome P450 3A4 isoform in primary hepatocytes.{29656}
Brand:CaymanSKU:- BMS-536924 is a dual inhibitor of insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IC50s = 100 and 73 nM, respectively).{29658} In this way, it blocks IGF-1R autophosphorylation and signaling through MEK1/2 and Akt, leading to G1 arrest and apoptosis in myeloblastic leukemia ML-1 cells. BMS-536924 reverses epithelial-to-mesenchymal transition in immortalized mammary epithelial MCF10A cells overexpressing constitutively activated IGF-1R and causes growth inhibition and polarization of breast cancer MCF-7 cells.{29655,29657} It also induces expression of cytochrome P450 3A4 isoform in primary hepatocytes.{29656}
Brand:CaymanSKU:-
BMS-777607 is an inhibitor of the Met kinase family. It inhibits Ron, Met, Tyro-3, and AxI with IC50 values of 1.8, 3.9, 4.3, and 1.1 nM, respectively.{29883} At higher concentrations it is reported to inhibit Mer, FLT3, Aurora B, Lck, and VEGFR2 (IC50s = 14, 16, 78, 120, and 180 nM, respectively).{29883} In cancer cells, BMS-777607 induces polyploidy with multiple sets of chromosomes, as well as suppresses metastasis.{29883,29882} In tumor xenograft models, BMS-777607 at 50 mg/kg/mouse inhibits the growth of tumor cells expressing Met/Ron.{29883}
Brand:CaymanSKU:-Available on backorder
BMS-777607 is an inhibitor of the Met kinase family. It inhibits Ron, Met, Tyro-3, and AxI with IC50 values of 1.8, 3.9, 4.3, and 1.1 nM, respectively.{29883} At higher concentrations it is reported to inhibit Mer, FLT3, Aurora B, Lck, and VEGFR2 (IC50s = 14, 16, 78, 120, and 180 nM, respectively).{29883} In cancer cells, BMS-777607 induces polyploidy with multiple sets of chromosomes, as well as suppresses metastasis.{29883,29882} In tumor xenograft models, BMS-777607 at 50 mg/kg/mouse inhibits the growth of tumor cells expressing Met/Ron.{29883}
Brand:CaymanSKU:-Available on backorder
BMS-777607 is an inhibitor of the Met kinase family. It inhibits Ron, Met, Tyro-3, and AxI with IC50 values of 1.8, 3.9, 4.3, and 1.1 nM, respectively.{29883} At higher concentrations it is reported to inhibit Mer, FLT3, Aurora B, Lck, and VEGFR2 (IC50s = 14, 16, 78, 120, and 180 nM, respectively).{29883} In cancer cells, BMS-777607 induces polyploidy with multiple sets of chromosomes, as well as suppresses metastasis.{29883,29882} In tumor xenograft models, BMS-777607 at 50 mg/kg/mouse inhibits the growth of tumor cells expressing Met/Ron.{29883}
Brand:CaymanSKU:-Available on backorder
BMS-777607 is an inhibitor of the Met kinase family. It inhibits Ron, Met, Tyro-3, and AxI with IC50 values of 1.8, 3.9, 4.3, and 1.1 nM, respectively.{29883} At higher concentrations it is reported to inhibit Mer, FLT3, Aurora B, Lck, and VEGFR2 (IC50s = 14, 16, 78, 120, and 180 nM, respectively).{29883} In cancer cells, BMS-777607 induces polyploidy with multiple sets of chromosomes, as well as suppresses metastasis.{29883,29882} In tumor xenograft models, BMS-777607 at 50 mg/kg/mouse inhibits the growth of tumor cells expressing Met/Ron.{29883}
Brand:CaymanSKU:-Available on backorder
BMS-8 is a small molecule inhibitor of the interaction between programmed death protein 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) with an IC50 value of 146 nM in a homogeneous time-resolved fluorescence (HTRF) binding assay.{40457}
Brand:CaymanSKU:22355 -Out of stock
BMS-8 is a small molecule inhibitor of the interaction between programmed death protein 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) with an IC50 value of 146 nM in a homogeneous time-resolved fluorescence (HTRF) binding assay.{40457}
Brand:CaymanSKU:22355 -Out of stock
BMS-8 is a small molecule inhibitor of the interaction between programmed death protein 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) with an IC50 value of 146 nM in a homogeneous time-resolved fluorescence (HTRF) binding assay.{40457}
Brand:CaymanSKU:22355 -Out of stock
BMS-8 is a small molecule inhibitor of the interaction between programmed death protein 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) with an IC50 value of 146 nM in a homogeneous time-resolved fluorescence (HTRF) binding assay.{40457}
Brand:CaymanSKU:22355 -Out of stock
BMS-806 is a small molecule that inhibits the first step of HIV-1 infection by blocking the binding of host cell CD4 with viral gp120 protein.{29893} It binds the exterior envelope glycoprotein gp120 (Kd= 21.1 nM; Ki = 24.9 nM), blocking the conformational change that occurs with CD4 binding and preventing fusion of the viral and target cell membranes.{29893,29895,29896} BMS-806 is specific to HIV-1 irrespective of chemokine receptor preference, with no activity against HIV-2, SIV, or a panel of additional viruses.{29894}
Brand:CaymanSKU:-Available on backorder
BMS-806 is a small molecule that inhibits the first step of HIV-1 infection by blocking the binding of host cell CD4 with viral gp120 protein.{29893} It binds the exterior envelope glycoprotein gp120 (Kd= 21.1 nM; Ki = 24.9 nM), blocking the conformational change that occurs with CD4 binding and preventing fusion of the viral and target cell membranes.{29893,29895,29896} BMS-806 is specific to HIV-1 irrespective of chemokine receptor preference, with no activity against HIV-2, SIV, or a panel of additional viruses.{29894}
Brand:CaymanSKU:-Available on backorder
BMS-806 is a small molecule that inhibits the first step of HIV-1 infection by blocking the binding of host cell CD4 with viral gp120 protein.{29893} It binds the exterior envelope glycoprotein gp120 (Kd= 21.1 nM; Ki = 24.9 nM), blocking the conformational change that occurs with CD4 binding and preventing fusion of the viral and target cell membranes.{29893,29895,29896} BMS-806 is specific to HIV-1 irrespective of chemokine receptor preference, with no activity against HIV-2, SIV, or a panel of additional viruses.{29894}
Brand:CaymanSKU:-Available on backorder
BMS-911543 is a potent, selective ATP-competitive inhibitor of Janus kinase 2 (JAK2) that exhibits IC50 values of 1, 356, 73, and 66 nM for JAK2, JAK1, JAK3, and TYK2, respectively.{33764} It exhibits antiproliferative activity in a variety of cell lines engineered to express the JAK2V617F activating mutation (IC50s = 60-70 nM).{33764,33765} BMS-911543 exhibited limited activity in a mouse model of JAK2V617F-driven myeloproliferative neoplasm.{33766}
Brand:CaymanSKU:21088 -Out of stock
BMS-911543 is a potent, selective ATP-competitive inhibitor of Janus kinase 2 (JAK2) that exhibits IC50 values of 1, 356, 73, and 66 nM for JAK2, JAK1, JAK3, and TYK2, respectively.{33764} It exhibits antiproliferative activity in a variety of cell lines engineered to express the JAK2V617F activating mutation (IC50s = 60-70 nM).{33764,33765} BMS-911543 exhibited limited activity in a mouse model of JAK2V617F-driven myeloproliferative neoplasm.{33766}
Brand:CaymanSKU:21088 -Out of stock
BMS-911543 is a potent, selective ATP-competitive inhibitor of Janus kinase 2 (JAK2) that exhibits IC50 values of 1, 356, 73, and 66 nM for JAK2, JAK1, JAK3, and TYK2, respectively.{33764} It exhibits antiproliferative activity in a variety of cell lines engineered to express the JAK2V617F activating mutation (IC50s = 60-70 nM).{33764,33765} BMS-911543 exhibited limited activity in a mouse model of JAK2V617F-driven myeloproliferative neoplasm.{33766}
Brand:CaymanSKU:21088 -Out of stock
BMS-911543 is a potent, selective ATP-competitive inhibitor of Janus kinase 2 (JAK2) that exhibits IC50 values of 1, 356, 73, and 66 nM for JAK2, JAK1, JAK3, and TYK2, respectively.{33764} It exhibits antiproliferative activity in a variety of cell lines engineered to express the JAK2V617F activating mutation (IC50s = 60-70 nM).{33764,33765} BMS-911543 exhibited limited activity in a mouse model of JAK2V617F-driven myeloproliferative neoplasm.{33766}
Brand:CaymanSKU:21088 -Out of stock
BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX; IC50 = 8 nM) that targets Cys496 in the BMX ATP binding domain.{31496} It additionally targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent for inhibition of Blk, JAK3, EGFR, Itk, or Tec activity. BMX-IN-1 was shown to inhibit the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells with a GI50 value of 25 nM.{31496} Antiproliferative activity was also observed in RV-1, DU-145, PC-3, and VCAP prostate cancer cell lines (GI50s = 2.54, 4.38, 5.37, and 2.46 µM, respectively).{31496}
Brand:CaymanSKU:-Available on backorder
BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX; IC50 = 8 nM) that targets Cys496 in the BMX ATP binding domain.{31496} It additionally targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent for inhibition of Blk, JAK3, EGFR, Itk, or Tec activity. BMX-IN-1 was shown to inhibit the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells with a GI50 value of 25 nM.{31496} Antiproliferative activity was also observed in RV-1, DU-145, PC-3, and VCAP prostate cancer cell lines (GI50s = 2.54, 4.38, 5.37, and 2.46 µM, respectively).{31496}
Brand:CaymanSKU:-Available on backorder
BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX; IC50 = 8 nM) that targets Cys496 in the BMX ATP binding domain.{31496} It additionally targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent for inhibition of Blk, JAK3, EGFR, Itk, or Tec activity. BMX-IN-1 was shown to inhibit the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells with a GI50 value of 25 nM.{31496} Antiproliferative activity was also observed in RV-1, DU-145, PC-3, and VCAP prostate cancer cell lines (GI50s = 2.54, 4.38, 5.37, and 2.46 µM, respectively).{31496}
Brand:CaymanSKU:-Available on backorder
BMY 7378 is an antagonist of the α2C-adrenoceptor and α1D-adrenoceptor with pKi values of 6.54 and 8.2, respectively, that has been used in functional systems to assess the contribution of these receptors in vascular smooth muscle contraction.{33564,33563} It also acts as a partial agonist at the serotonin 5-HT1A receptor with a pKi value of 8.3.{33564}
Brand:CaymanSKU:21369 -Out of stock
BMY 7378 is an antagonist of the α2C-adrenoceptor and α1D-adrenoceptor with pKi values of 6.54 and 8.2, respectively, that has been used in functional systems to assess the contribution of these receptors in vascular smooth muscle contraction.{33564,33563} It also acts as a partial agonist at the serotonin 5-HT1A receptor with a pKi value of 8.3.{33564}
Brand:CaymanSKU:21369 -Out of stock
BMY 7378 is an antagonist of the α2C-adrenoceptor and α1D-adrenoceptor with pKi values of 6.54 and 8.2, respectively, that has been used in functional systems to assess the contribution of these receptors in vascular smooth muscle contraction.{33564,33563} It also acts as a partial agonist at the serotonin 5-HT1A receptor with a pKi value of 8.3.{33564}
Brand:CaymanSKU:21369 -Out of stock
BMY 7378 is an antagonist of the α2C-adrenoceptor and α1D-adrenoceptor with pKi values of 6.54 and 8.2, respectively, that has been used in functional systems to assess the contribution of these receptors in vascular smooth muscle contraction.{33564,33563} It also acts as a partial agonist at the serotonin 5-HT1A receptor with a pKi value of 8.3.{33564}
Brand:CaymanSKU:21369 -Out of stock
Antigen: synthetic peptide from human Bnc 1 within the region of amino acids 330-380 • Host: rabbit • Cross-reactivity: (+) chimpanzee, human, and monkey Bnc 1 • Application(s): WB • Bnc 1 is a 994 amino acid transcription factor specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. It is a soluble protein that can shuttle between the nucleus and the cytoplasm. Phosphorylation on Ser537 and Ser541 leads to its cytoplasmic localization.
Brand:CaymanSKU:13502- 1 eaAvailable on backorder
Antigen: synthetic peptide from human Bnc 1 within the region of amino acids 330-380 • Host: rabbit • Cross-reactivity: (+) chimpanzee, human, and monkey Bnc 1 • Application(s): WB • Bnc 1 is a 994 amino acid transcription factor specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. It is a soluble protein that can shuttle between the nucleus and the cytoplasm. Phosphorylation on Ser537 and Ser541 leads to its cytoplasmic localization.
Brand:CaymanSKU:13502- 1 ea Bnc 1 is a 994 amino acid transcription factor specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. It is a zinc finger protein with three separated pairs of zinc fingers and a nuclear localization signal. Bnc 1 is a soluble protein that can shuttle between the nucleus and the cytoplasm, and its location depends on the proliferative potential of the cell. It is expressed relatively uniformly in the nucleoplasm, and phosphorylation on Ser537 and Ser541 leads to its cytoplasmic localization. It is present in the basal cell layer of the epidermis, in hair follicles and also in abundance in the germ cells of testis and ovary, and to a lower extent in thymus, spleen, mammary glands, placenta, brain, and heart. Reports suggest that it plays a regulatory role in keratinocyte proliferation and also in rRNA transcription. It is also known to play a role in the differentiation of spermatozoa and oocytes.
Brand:CaymanSKU:13502 - 1 eaAvailable on backorder
Bobcat 339 is an inhibitor of ten-eleven translocation methylcytosine dioxygenase 1 (TET1) and TET2 (IC50s = 33 and 73 µM, respectively).{61034} It is selective for TET1 and TET2 over DNA methyltransferase 3a (DNMT3a) at 500 µM. Bobcat 339 (10 µM) reduces DNA 5-hydroxymethylcytosine (5-hmC) levels in HT22 hippocampal neurons.
Brand:CaymanSKU:31453 - 1 mgAvailable on backorder
Bobcat 339 is an inhibitor of ten-eleven translocation methylcytosine dioxygenase 1 (TET1) and TET2 (IC50s = 33 and 73 µM, respectively).{61034} It is selective for TET1 and TET2 over DNA methyltransferase 3a (DNMT3a) at 500 µM. Bobcat 339 (10 µM) reduces DNA 5-hydroxymethylcytosine (5-hmC) levels in HT22 hippocampal neurons.
Brand:CaymanSKU:31453 - 10 mgAvailable on backorder
Bobcat 339 is an inhibitor of ten-eleven translocation methylcytosine dioxygenase 1 (TET1) and TET2 (IC50s = 33 and 73 µM, respectively).{61034} It is selective for TET1 and TET2 over DNA methyltransferase 3a (DNMT3a) at 500 µM. Bobcat 339 (10 µM) reduces DNA 5-hydroxymethylcytosine (5-hmC) levels in HT22 hippocampal neurons.
Brand:CaymanSKU:31453 - 25 mgAvailable on backorder
Bobcat 339 is an inhibitor of ten-eleven translocation methylcytosine dioxygenase 1 (TET1) and TET2 (IC50s = 33 and 73 µM, respectively).{61034} It is selective for TET1 and TET2 over DNA methyltransferase 3a (DNMT3a) at 500 µM. Bobcat 339 (10 µM) reduces DNA 5-hydroxymethylcytosine (5-hmC) levels in HT22 hippocampal neurons.
Brand:CaymanSKU:31453 - 5 mgAvailable on backorder
BOC-(1R,3S)-3-Aminocyclopentane carboxylic acid is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:11405 - 50 mgAvailable on backorder
BOC-(1S,3R)-3-Aminocyclopentane carboxylic acid is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:11406 - 50 mgAvailable on backorder
Boc-Arg(Boc)2-OH is an amino acid building block and derivative of arginine.{46890,46891} It has been used in the synthesis of amino acid prodrug forms of cytotoxic anthraquinones with anticancer activity.{46891}
Brand:CaymanSKU:30522 - 1 gAvailable on backorder
Boc-Arg(Boc)2-OH is an amino acid building block and derivative of arginine.{46890,46891} It has been used in the synthesis of amino acid prodrug forms of cytotoxic anthraquinones with anticancer activity.{46891}
Brand:CaymanSKU:30522 - 500 mgAvailable on backorder
Boc-D-FMK is a cell-permeable, irreversible pan-caspase inhibitor.{26387,26384} Also known as Boc-D(OMe)-FMK, this compound contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor. Boc-D-FMK blocks apoptosis stimulated by TNF-α in neutrophils (IC50 = 39 µM), by bile duct ligation in hepatocytes, and by TNF-α in renal endothelial cells.{26383,26385,26386} The FMK pharmacophore is known to interact with non-caspase cysteine proteases, presumably explaining why Boc-D-FMK also inhibits cathepsins H and L.{26387}
Brand:CaymanSKU:- Boc-D-FMK is a cell-permeable, irreversible pan-caspase inhibitor.{26387,26384} Also known as Boc-D(OMe)-FMK, this compound contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor. Boc-D-FMK blocks apoptosis stimulated by TNF-α in neutrophils (IC50 = 39 µM), by bile duct ligation in hepatocytes, and by TNF-α in renal endothelial cells.{26383,26385,26386} The FMK pharmacophore is known to interact with non-caspase cysteine proteases, presumably explaining why Boc-D-FMK also inhibits cathepsins H and L.{26387}
Brand:CaymanSKU:- Boc-D-FMK is a cell-permeable, irreversible pan-caspase inhibitor.{26387,26384} Also known as Boc-D(OMe)-FMK, this compound contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor. Boc-D-FMK blocks apoptosis stimulated by TNF-α in neutrophils (IC50 = 39 µM), by bile duct ligation in hepatocytes, and by TNF-α in renal endothelial cells.{26383,26385,26386} The FMK pharmacophore is known to interact with non-caspase cysteine proteases, presumably explaining why Boc-D-FMK also inhibits cathepsins H and L.{26387}
Brand:CaymanSKU:-
Boc-D-Leu-OSu is an amino acid-containing building block.{46906,46907} It has been used in the synthesis of peptide gastrin antagonists, as well as analogs of the peptide antibiotic gramicidin S.
Brand:CaymanSKU:30543 - 1 gAvailable on backorder
Boc-D-Leu-OSu is an amino acid-containing building block.{46906,46907} It has been used in the synthesis of peptide gastrin antagonists, as well as analogs of the peptide antibiotic gramicidin S.
Brand:CaymanSKU:30543 - 500 mgAvailable on backorder
Boc-Glu-OBzl is an amino acid building block.{7777,52497} It has been used in the synthesis of peptide-based inhibitors of human caspases and human rhinovirus (HRV) 3C protease that have enzyme inhibitory activity in vitro.
Brand:CaymanSKU:30464 - 1 gAvailable on backorder
Boc-Glu-OBzl is an amino acid building block.{7777,52497} It has been used in the synthesis of peptide-based inhibitors of human caspases and human rhinovirus (HRV) 3C protease that have enzyme inhibitory activity in vitro.
Brand:CaymanSKU:30464 - 5 gAvailable on backorder
Boc-L-Arg-OH is an amino acid building block.{49613,49614,49615} It has been used in the synthesis of antibacterial peptides and as an in vitro model substrate in the study of methylglyoxal peptide crosslinking via the Maillard reaction.
Brand:CaymanSKU:30448 - 1 gAvailable on backorder
Boc-L-Arg-OH is an amino acid building block.{49613,49614,49615} It has been used in the synthesis of antibacterial peptides and as an in vitro model substrate in the study of methylglyoxal peptide crosslinking via the Maillard reaction.
Brand:CaymanSKU:30448 - 5 gAvailable on backorder
Boc-Leu-Leu-OH is a peptide building block.{54085} It has been used in the synthesis of a peptide-based curcumin derivative with anticancer activity in vitro. It has also been used in the synthesis of fluorescent peptides containing naphthalene and protoporphyrin IX.{54086}
Brand:CaymanSKU:30499 - 1 gAvailable on backorder
Boc-Leu-Leu-OH is a peptide building block.{54085} It has been used in the synthesis of a peptide-based curcumin derivative with anticancer activity in vitro. It has also been used in the synthesis of fluorescent peptides containing naphthalene and protoporphyrin IX.{54086}
Brand:CaymanSKU:30499 - 10 gAvailable on backorder
Boc-Leu-Leu-OH is a peptide building block.{54085} It has been used in the synthesis of a peptide-based curcumin derivative with anticancer activity in vitro. It has also been used in the synthesis of fluorescent peptides containing naphthalene and protoporphyrin IX.{54086}
Brand:CaymanSKU:30499 - 25 gAvailable on backorder
Boc-Leu-Leu-OH is a peptide building block.{54085} It has been used in the synthesis of a peptide-based curcumin derivative with anticancer activity in vitro. It has also been used in the synthesis of fluorescent peptides containing naphthalene and protoporphyrin IX.{54086}
Brand:CaymanSKU:30499 - 5 gAvailable on backorder
Boc-LRR-AMC is a fluorogenic substrate for the trypsin-like activity of the 26S proteasome or 20S proteolytic core.{41518,42816} Upon enzymatic cleavage by the 26S proteasome or 20S proteolytic core, amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify 26S proteasome or 20S proteolytic core trypsin-like activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
Brand:CaymanSKU:26642 - 1 mgAvailable on backorder
Boc-LRR-AMC is a fluorogenic substrate for the trypsin-like activity of the 26S proteasome or 20S proteolytic core.{41518,42816} Upon enzymatic cleavage by the 26S proteasome or 20S proteolytic core, amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify 26S proteasome or 20S proteolytic core trypsin-like activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
Brand:CaymanSKU:26642 - 10 mgAvailable on backorder
Boc-LRR-AMC is a fluorogenic substrate for the trypsin-like activity of the 26S proteasome or 20S proteolytic core.{41518,42816} Upon enzymatic cleavage by the 26S proteasome or 20S proteolytic core, amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify 26S proteasome or 20S proteolytic core trypsin-like activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
Brand:CaymanSKU:26642 - 5 mgAvailable on backorder
Boc-Lys(Ac)-AMC is a fluorescent substrate for histone deacetylases (HDACs).{12266} Following deacetylation by an HDAC, Boc-Lys-AMC is cleaved by trypsin and 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify HDAC activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
Brand:CaymanSKU:29682 - 10 mgAvailable on backorder
Boc-Lys(Ac)-AMC is a fluorescent substrate for histone deacetylases (HDACs).{12266} Following deacetylation by an HDAC, Boc-Lys-AMC is cleaved by trypsin and 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify HDAC activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
Brand:CaymanSKU:29682 - 25 mgAvailable on backorder
Boc-Lys(Ac)-AMC is a fluorescent substrate for histone deacetylases (HDACs).{12266} Following deacetylation by an HDAC, Boc-Lys-AMC is cleaved by trypsin and 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify HDAC activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
Brand:CaymanSKU:29682 - 5 mgAvailable on backorder
Boc-Lys(Ac)-AMC is a fluorescent substrate for histone deacetylases (HDACs).{12266} Following deacetylation by an HDAC, Boc-Lys-AMC is cleaved by trypsin and 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify HDAC activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
Brand:CaymanSKU:29682 - 50 mgAvailable on backorder
Boc-NH-PEG3-CH2COOH is a building block.{53629,53630} It has been used as a linker in the synthesis of proteolysis-targeting chimeras (PROTACs) targeting MEK.{53629} It has also been used as a spacer in the synthesis of radiolabeled probes for dual labeling of tumor integrin αVβ3 and the gastrin-releasing peptide receptor (GRPR) in tumor tissue in vivo.{53630}
Brand:CaymanSKU:30536 - 100 mgAvailable on backorder
Boc-NH-PEG3-CH2COOH is a building block.{53629,53630} It has been used as a linker in the synthesis of proteolysis-targeting chimeras (PROTACs) targeting MEK.{53629} It has also been used as a spacer in the synthesis of radiolabeled probes for dual labeling of tumor integrin αVβ3 and the gastrin-releasing peptide receptor (GRPR) in tumor tissue in vivo.{53630}
Brand:CaymanSKU:30536 - 25 mgAvailable on backorder
Boc-NH-PEG3-CH2COOH is a building block.{53629,53630} It has been used as a linker in the synthesis of proteolysis-targeting chimeras (PROTACs) targeting MEK.{53629} It has also been used as a spacer in the synthesis of radiolabeled probes for dual labeling of tumor integrin αVβ3 and the gastrin-releasing peptide receptor (GRPR) in tumor tissue in vivo.{53630}
Brand:CaymanSKU:30536 - 250 mgAvailable on backorder
Boc-NH-PEG3-CH2COOH is a building block.{53629,53630} It has been used as a linker in the synthesis of proteolysis-targeting chimeras (PROTACs) targeting MEK.{53629} It has also been used as a spacer in the synthesis of radiolabeled probes for dual labeling of tumor integrin αVβ3 and the gastrin-releasing peptide receptor (GRPR) in tumor tissue in vivo.{53630}
Brand:CaymanSKU:30536 - 50 mgAvailable on backorder
Boc-NH-PEG3-OH is a PEGylated building block that contains a tert-butyloxy carbonyl (Boc) protecting group.{53606} It has been used as a spacer in biotinylated heterobifunctional cross-linker agents and in near infrared imaging probes for the cytochrome P450 (CYP) isoform CYP1B1, which is expressed in a variety of tumors.{53606,53607} Boc-NH-PEG3-OH has also been used in the synthesis of graftable peptidomimetics that bind to human αVβ3 integrin and inhibit adhesion of human osteoprogenitor cells to vitronectin.{53608}
Brand:CaymanSKU:30496 - 100 mgAvailable on backorder
Boc-NH-PEG3-OH is a PEGylated building block that contains a tert-butyloxy carbonyl (Boc) protecting group.{53606} It has been used as a spacer in biotinylated heterobifunctional cross-linker agents and in near infrared imaging probes for the cytochrome P450 (CYP) isoform CYP1B1, which is expressed in a variety of tumors.{53606,53607} Boc-NH-PEG3-OH has also been used in the synthesis of graftable peptidomimetics that bind to human αVβ3 integrin and inhibit adhesion of human osteoprogenitor cells to vitronectin.{53608}
Brand:CaymanSKU:30496 - 250 mgAvailable on backorder
Boc-NH-PEG3-OH is a PEGylated building block that contains a tert-butyloxy carbonyl (Boc) protecting group.{53606} It has been used as a spacer in biotinylated heterobifunctional cross-linker agents and in near infrared imaging probes for the cytochrome P450 (CYP) isoform CYP1B1, which is expressed in a variety of tumors.{53606,53607} Boc-NH-PEG3-OH has also been used in the synthesis of graftable peptidomimetics that bind to human αVβ3 integrin and inhibit adhesion of human osteoprogenitor cells to vitronectin.{53608}
Brand:CaymanSKU:30496 - 50 mgAvailable on backorder
Boc-NH-PEG3-OH is a PEGylated building block that contains a tert-butyloxy carbonyl (Boc) protecting group.{53606} It has been used as a spacer in biotinylated heterobifunctional cross-linker agents and in near infrared imaging probes for the cytochrome P450 (CYP) isoform CYP1B1, which is expressed in a variety of tumors.{53606,53607} Boc-NH-PEG3-OH has also been used in the synthesis of graftable peptidomimetics that bind to human αVβ3 integrin and inhibit adhesion of human osteoprogenitor cells to vitronectin.{53608}
Brand:CaymanSKU:30496 - 500 mgAvailable on backorder
Boc-Orn(Fmoc)-OH is an amino acid-containing building block.{46899} It has been used to introduce δ-linked ornithine turns into synthetic macrocyclic β-sheets.{46899,46900}
Brand:CaymanSKU:30495 - 1 gAvailable on backorder
Boc-Orn(Fmoc)-OH is an amino acid-containing building block.{46899} It has been used to introduce δ-linked ornithine turns into synthetic macrocyclic β-sheets.{46899,46900}
Brand:CaymanSKU:30495 - 500 mgAvailable on backorder
Boceprevir is an inhibitor of hepatitis C virus (HCV) non-structural protease 3/4A (NS3/4A; Ki = 14 nM for the HCV genotype 1b enzyme).{30614} Boceprevir inhibits HCV replication in Huh7 cells (EC50 = 200 nM).{36164} It also inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro; Ki = 1.8 µM) and reduces cytopathic effects of SARS-CoV-2 in Vero cells (EC50 = 1.31 µM).{58053} Formulations containing boceprevir have been used in the treatment of HCV.
Brand:CaymanSKU:-Available on backorder
Boceprevir is an inhibitor of hepatitis C virus (HCV) non-structural protease 3/4A (NS3/4A; Ki = 14 nM for the HCV genotype 1b enzyme).{30614} Boceprevir inhibits HCV replication in Huh7 cells (EC50 = 200 nM).{36164} It also inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro; Ki = 1.8 µM) and reduces cytopathic effects of SARS-CoV-2 in Vero cells (EC50 = 1.31 µM).{58053} Formulations containing boceprevir have been used in the treatment of HCV.
Brand:CaymanSKU:-Available on backorder
Boceprevir is an inhibitor of hepatitis C virus (HCV) non-structural protease 3/4A (NS3/4A; Ki = 14 nM for the HCV genotype 1b enzyme).{30614} Boceprevir inhibits HCV replication in Huh7 cells (EC50 = 200 nM).{36164} It also inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro; Ki = 1.8 µM) and reduces cytopathic effects of SARS-CoV-2 in Vero cells (EC50 = 1.31 µM).{58053} Formulations containing boceprevir have been used in the treatment of HCV.
Brand:CaymanSKU:-Available on backorder
Boceprevir is an inhibitor of hepatitis C virus (HCV) non-structural protease 3/4A (NS3/4A; Ki = 14 nM for the HCV genotype 1b enzyme).{30614} Boceprevir inhibits HCV replication in Huh7 cells (EC50 = 200 nM).{36164} It also inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro; Ki = 1.8 µM) and reduces cytopathic effects of SARS-CoV-2 in Vero cells (EC50 = 1.31 µM).{58053} Formulations containing boceprevir have been used in the treatment of HCV.
Brand:CaymanSKU:-Available on backorder
Boceprevir-d9 is intended for use as an internal standard for the quantification of boceprevir (Item No. 18379) by GC- or LC-MS. Boceprevir is an inhibitor of hepatitis C virus (HCV) non-structural protease 3/4A (NS3/4A; Ki = 14 nM for the HCV genotype 1b enzyme).{30614} Boceprevir inhibits HCV replication in Huh7 cells (EC50 = 200 nM).{36164} It also inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro; Ki = 1.8 µM) and reduces cytopathic effects of SARS-CoV-2 in Vero cells (EC50 = 1.31 µM).{58053} Formulations containing boceprevir have been used in the treatment of HCV.
Brand:CaymanSKU:31461 - 500 µgAvailable on backorder
BODIPY 493/503 is a lipophilic fluorescent probe that localizes to polar lipids and can be used to label cellular neutral lipid contents, particularly those localized to lipid droplets, in live and fixed cells.{17124,43470} BODIPY 493/503 is compatible with epifluorescent, confocal, and two-photon microscopy, as well as flow cytometry. It displays excitation/emission maxima of 493/503 nm, respectively, and can be used for live and fixed cell applications.
Brand:CaymanSKU:25892 - 10 mgAvailable on backorder
BODIPY 493/503 is a lipophilic fluorescent probe that localizes to polar lipids and can be used to label cellular neutral lipid contents, particularly those localized to lipid droplets, in live and fixed cells.{17124,43470} BODIPY 493/503 is compatible with epifluorescent, confocal, and two-photon microscopy, as well as flow cytometry. It displays excitation/emission maxima of 493/503 nm, respectively, and can be used for live and fixed cell applications.
Brand:CaymanSKU:25892 - 5 mgAvailable on backorder
BODIPY 503/512 is a lipophilic, amine-reactive fluorescent probe.{48577} It has been used to label oligonucleotide probes and primers for the quantitation of DNA and RNA by PCR and to monitor the uptake and trafficking of BODIPY-labeled proteins and other compounds within cells by fluorescence microscopy.{48578,48579,48580,48577} BODIPY 503/512 has also been used to identify and sort adipocytes from mouse white and brown adipose tissue by flow cytometry.{48581} It displays excitation/emission maxima of 503/512 nm, respectively.{48577}
Brand:CaymanSKU:28800 - 1 mgAvailable on backorder
BODIPY 503/512 is a lipophilic, amine-reactive fluorescent probe.{48577} It has been used to label oligonucleotide probes and primers for the quantitation of DNA and RNA by PCR and to monitor the uptake and trafficking of BODIPY-labeled proteins and other compounds within cells by fluorescence microscopy.{48578,48579,48580,48577} BODIPY 503/512 has also been used to identify and sort adipocytes from mouse white and brown adipose tissue by flow cytometry.{48581} It displays excitation/emission maxima of 503/512 nm, respectively.{48577}
Brand:CaymanSKU:28800 - 10 mgAvailable on backorder