Cayman
Showing 1051–1200 of 45550 results
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α-Hydroxyglutaric acid (2-HG; Item No. 16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder.{26770,26771,26772} Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than α-ketoglutarate.{26773,26775} 2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.{26775,26774,26769} (2R)-Octyl-α-hydroxyglutarate is a cell-permeable derivative of the D-isomer of 2-HG. It has been used to examine the contribution of D-2HG to the oxidative mitochondrial processes of IDH1-mutated cancer cells.{28419}
Brand:CaymanSKU:-Out of stock
α-Hydroxyglutaric acid (2-HG; Item No. 16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder.{26770,26771,26772} Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than α-ketoglutarate.{26773,26775} 2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.{26775,26774,26769} (2R)-Octyl-α-hydroxyglutarate is a cell-permeable derivative of the D-isomer of 2-HG. It has been used to examine the contribution of D-2HG to the oxidative mitochondrial processes of IDH1-mutated cancer cells.{28419}
Brand:CaymanSKU:-Out of stock
α-Hydroxyglutaric acid (2-HG; Item No. 16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder.{26770,26771,26772} Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than α-ketoglutarate.{26773,26775} 2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.{26775,26774,26769} (2S)-Octyl-α-hydroxyglutarate is a cell-permeable derivative of the L-isomer of 2-HG.
Brand:CaymanSKU:-Out of stock
α-Hydroxyglutaric acid (2-HG; Item No. 16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder.{26770,26771,26772} Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than α-ketoglutarate.{26773,26775} 2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.{26775,26774,26769} (2S)-Octyl-α-hydroxyglutarate is a cell-permeable derivative of the L-isomer of 2-HG.
Brand:CaymanSKU:-Out of stock
α-Hydroxyglutaric acid (2-HG; Item No. 16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder.{26770,26771,26772} Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than α-ketoglutarate.{26773,26775} 2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.{26775,26774,26769} (2S)-Octyl-α-hydroxyglutarate is a cell-permeable derivative of the L-isomer of 2-HG.
Brand:CaymanSKU:-Out of stock
Lysophosphatidic acid (LPA) is a potent lipid mediator that elicits its effect through four distinct receptors – LPA1/EDG-2, LPA2/EDG-4, LPA3/EDG-7 and LPA4/GPR23.{11049,13009} OMPT is a selective agonist of the lysophosphatidic acid 3 (LPA3) receptor. It exhibits EC50 values of 68 nM and >6.8 µM for calcium mobilization in LPA1 and LPA2-expressing Sf9 cells, respectively.{11057} The (2S)-OMPT enantiomer is 5- to 20-fold more active than (2R)-OMPT in calcium release assays in both LPA3-transfected Sf9 and rat hepatoma Rh7777 cells.{13369}
Brand:CaymanSKU:10005707 - 1 mgAvailable on backorder
Lysophosphatidic acid (LPA) is a potent lipid mediator that elicits its effect through four distinct receptors – LPA1/EDG-2, LPA2/EDG-4, LPA3/EDG-7 and LPA4/GPR23.{11049,13009} OMPT is a selective agonist of the lysophosphatidic acid 3 (LPA3) receptor. It exhibits EC50 values of 68 nM and >6.8 µM for calcium mobilization in LPA1 and LPA2-expressing Sf9 cells, respectively.{11057} The (2S)-OMPT enantiomer is 5- to 20-fold more active than (2R)-OMPT in calcium release assays in both LPA3-transfected Sf9 and rat hepatoma Rh7777 cells.{13369}
Brand:CaymanSKU:10005707 - 10 mgAvailable on backorder
Lysophosphatidic acid (LPA) is a potent lipid mediator that elicits its effect through four distinct receptors – LPA1/EDG-2, LPA2/EDG-4, LPA3/EDG-7 and LPA4/GPR23.{11049,13009} OMPT is a selective agonist of the lysophosphatidic acid 3 (LPA3) receptor. It exhibits EC50 values of 68 nM and >6.8 µM for calcium mobilization in LPA1 and LPA2-expressing Sf9 cells, respectively.{11057} The (2S)-OMPT enantiomer is 5- to 20-fold more active than (2R)-OMPT in calcium release assays in both LPA3-transfected Sf9 and rat hepatoma Rh7777 cells.{13369}
Brand:CaymanSKU:10005707 - 5 mgAvailable on backorder
Lysophosphatidic acid (LPA) is a potent lipid mediator that elicits its effect through four distinct receptors – LPA1/EDG-2, LPA2/EDG-4, LPA3/EDG-7 and LPA4/GPR23.{11049,13009} OMPT is a selective agonist of the lysophosphatidic acid 3 (LPA3) receptor. It exhibits EC50 values of 68 nM and >6.8 µM for calcium mobilization in LPA1 and LPA2-expressing Sf9 cells, respectively.{11057} The (2S)-OMPT enantiomer is 5- to 20-fold more active than (2R)-OMPT in calcium release assays in both LPA3-transfected Sf9 and rat hepatoma Rh7777 cells.{13369}
Brand:CaymanSKU:10005707 - 500 µgAvailable on backorder
(3R,8S)-Falcarindiol is a polyacetylene that has been found in N. incisum and has diverse biological activities.{54293,54294,54295} It is active against M. tuberculosis strain H37Ra (MIC = 6.25 μg/ml).{54293} (3R,8S)-Falcarindiol is cytotoxic to MCF-7, H1299, and HepG2 cells (IC50s = 29.4, 22.1, and 23.6 μM, respectively).{54294} It has algicidal activity against H. circularisquama when used at concentrations of 2 and 4 μM.{54295}
Brand:CaymanSKU:30919 - 1 mgAvailable on backorder
(3R,8S)-Falcarindiol is a polyacetylene that has been found in N. incisum and has diverse biological activities.{54293,54294,54295} It is active against M. tuberculosis strain H37Ra (MIC = 6.25 μg/ml).{54293} (3R,8S)-Falcarindiol is cytotoxic to MCF-7, H1299, and HepG2 cells (IC50s = 29.4, 22.1, and 23.6 μM, respectively).{54294} It has algicidal activity against H. circularisquama when used at concentrations of 2 and 4 μM.{54295}
Brand:CaymanSKU:30919 - 10 mgAvailable on backorder
(3R,8S)-Falcarindiol is a polyacetylene that has been found in N. incisum and has diverse biological activities.{54293,54294,54295} It is active against M. tuberculosis strain H37Ra (MIC = 6.25 μg/ml).{54293} (3R,8S)-Falcarindiol is cytotoxic to MCF-7, H1299, and HepG2 cells (IC50s = 29.4, 22.1, and 23.6 μM, respectively).{54294} It has algicidal activity against H. circularisquama when used at concentrations of 2 and 4 μM.{54295}
Brand:CaymanSKU:30919 - 5 mgAvailable on backorder
(3R)-hydroxy Quinidine is an isomer of (3S)-hydroxy quinidine (Item No. 23411), the major metabolite of quinidine.{40353}
Brand:CaymanSKU:23410 - 1 mgAvailable on backorder
Atorvastatin (Item No. 10493) is an HMG-CoA reductase inhibitor (IC50 = 154 nM) that is effective against hypercholesterolemia and certain dyslipidemias.{18240,18241,18235} Atorvastatin can exist in four optical forms, with the 3R,5R enantiomer displaying the greatest activity against HMG-CoA reductase. (3S,5S)-Atorvastatin is an enantiomer of atorvastatin that has little or no inhibitory activity against HMG-CoA reductase.{29980} It also differs from other atorvastatin enantiomers in cytotoxicity, activation of the pregnane X receptor, and induction of cytochrome P450 isoforms.{29980,29981}
Brand:CaymanSKU:-Available on backorder
Atorvastatin (Item No. 10493) is an HMG-CoA reductase inhibitor (IC50 = 154 nM) that is effective against hypercholesterolemia and certain dyslipidemias.{18240,18241,18235} Atorvastatin can exist in four optical forms, with the 3R,5R enantiomer displaying the greatest activity against HMG-CoA reductase. (3S,5S)-Atorvastatin is an enantiomer of atorvastatin that has little or no inhibitory activity against HMG-CoA reductase.{29980} It also differs from other atorvastatin enantiomers in cytotoxicity, activation of the pregnane X receptor, and induction of cytochrome P450 isoforms.{29980,29981}
Brand:CaymanSKU:-Available on backorder
Atorvastatin (Item No. 10493) is an HMG-CoA reductase inhibitor (IC50 = 154 nM) that is effective against hypercholesterolemia and certain dyslipidemias.{18240,18241,18235} Atorvastatin can exist in four optical forms, with the 3R,5R enantiomer displaying the greatest activity against HMG-CoA reductase. (3S,5S)-Atorvastatin is an enantiomer of atorvastatin that has little or no inhibitory activity against HMG-CoA reductase.{29980} It also differs from other atorvastatin enantiomers in cytotoxicity, activation of the pregnane X receptor, and induction of cytochrome P450 isoforms.{29980,29981}
Brand:CaymanSKU:-Available on backorder
(3S)-hydroxy Quinidine is an active quinidine metabolite.{38062} Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, CYP2E1, and CYP3A5, with CYP3A4 being the most active enzyme in the (3S)-hydroxy quinidine formation. (3S)-hydroxy Quinidine prolongs repolarization of canine Purkinje fibers in vitro and prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in isolated rat hearts in a dose-dependent manner.{36200,36201}
Brand:CaymanSKU:23411 - 1 mgAvailable on backorder
(3S)-hydroxy Quinidine is an active quinidine metabolite.{38062} Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, CYP2E1, and CYP3A5, with CYP3A4 being the most active enzyme in the (3S)-hydroxy quinidine formation. (3S)-hydroxy Quinidine prolongs repolarization of canine Purkinje fibers in vitro and prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in isolated rat hearts in a dose-dependent manner.{36200,36201}
Brand:CaymanSKU:23411 - 500 µgAvailable on backorder
(4-Chloro-3,5-dimethylphenoxy)acetic acid is a synthetic auxin, a class of plant growth regulators, that has been used to promote hypocotyl elongation during seedling emergence.{27598}
Brand:CaymanSKU:-Out of stock
(4-Chloro-3,5-dimethylphenoxy)acetic acid is a synthetic auxin, a class of plant growth regulators, that has been used to promote hypocotyl elongation during seedling emergence.{27598}
Brand:CaymanSKU:-Out of stock
(4-Chloro-3,5-dimethylphenoxy)acetic acid is a synthetic auxin, a class of plant growth regulators, that has been used to promote hypocotyl elongation during seedling emergence.{27598}
Brand:CaymanSKU:-Out of stock
(4-Chloro-3,5-dimethylphenoxy)acetic acid is a synthetic auxin, a class of plant growth regulators, that has been used to promote hypocotyl elongation during seedling emergence.{27598}
Brand:CaymanSKU:-Out of stock
Brand:CaymanSKU:29891 - 10 mgAvailable on backorder
Brand:CaymanSKU:29891 - 100 mgAvailable on backorder
Brand:CaymanSKU:29891 - 50 mgAvailable on backorder
(5E)-7-Oxozeaenol is a resorcylic acid lactone that has been found in the fungus MSX 63935 and has enzyme inhibitory and anticancer activities.{45257,49486} It inhibits TGF-β-activated kinase 1 (TAK-1; IC50 = 1.3 µM).{45257} (5E)-7-Oxozeaenol inhibits proliferation of MCF-7, H460, SF-268, HT-29, and MDA-MB-435 human cancer cells with IC50 values of 4.9, 1.2, 5.6, 4.4, and 5.5 µM, respectively.{49486}
Brand:CaymanSKU:29840 - 1 mgAvailable on backorder
(5E)-7-Oxozeaenol is a resorcylic acid lactone that has been found in the fungus MSX 63935 and has enzyme inhibitory and anticancer activities.{45257,49486} It inhibits TGF-β-activated kinase 1 (TAK-1; IC50 = 1.3 µM).{45257} (5E)-7-Oxozeaenol inhibits proliferation of MCF-7, H460, SF-268, HT-29, and MDA-MB-435 human cancer cells with IC50 values of 4.9, 1.2, 5.6, 4.4, and 5.5 µM, respectively.{49486}
Brand:CaymanSKU:29840 - 5 mgAvailable on backorder
(5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid is a stable isomer of 15(S)-HETE (Item No. 34720), a major arachidonic acid metabolite from the 15-lipoxygenase pathway.{31168} (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid elicits concentration-dependent contraction of isolated pulmonary arteries from rabbits and inhibits the proliferation and migration of hormone-independent prostate carcinoma PC-3 cells.{31168}
Brand:CaymanSKU:-Available on backorder
(5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid is a stable isomer of 15(S)-HETE (Item No. 34720), a major arachidonic acid metabolite from the 15-lipoxygenase pathway.{31168} (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid elicits concentration-dependent contraction of isolated pulmonary arteries from rabbits and inhibits the proliferation and migration of hormone-independent prostate carcinoma PC-3 cells.{31168}
Brand:CaymanSKU:-Available on backorder
(5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid is a stable isomer of 15(S)-HETE (Item No. 34720), a major arachidonic acid metabolite from the 15-lipoxygenase pathway.{31168} (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid elicits concentration-dependent contraction of isolated pulmonary arteries from rabbits and inhibits the proliferation and migration of hormone-independent prostate carcinoma PC-3 cells.{31168}
Brand:CaymanSKU:-Available on backorder
(5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid is a stable isomer of 15(S)-HETE (Item No. 34720), a major arachidonic acid metabolite from the 15-lipoxygenase pathway.{31168} (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid elicits concentration-dependent contraction of isolated pulmonary arteries from rabbits and inhibits the proliferation and migration of hormone-independent prostate carcinoma PC-3 cells.{31168}
Brand:CaymanSKU:-Available on backorder
Transforming growth factor-β-activated kinase 1 (TAK-1) is a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family that activates JNK/p38 and NF-κB pro-inflammatory signaling pathways. (5Z)-7-Oxozeaenol is a natural resorcylic lactone derived from fungi that selectively inhibits purified TAK-1 (IC50 = 8.1 nM when co-expressed with the TAK-1-binding protein) without significantly affecting the kinase activities of other MAPKKK family members (IC50 = 411 nM for MEK1).{28252} In cells, (5Z)-7-Oxozeaenol is reported to irreversibly block IL-1-induced activation of TAK-1, NF-κB, and JNK/p38 with IC50 values of 65-83 nM.{28252} (5Z)-7-Oxozeaenol has also been shown to inhibit IL-1-induced COX-2 production in cells and to relieve ear swelling induced by picryl chloride in a mouse model of COX-2-mediated inflammation.{28252} This compound has been found to sensitize cells to TRAIL- and TNF-α-induced apoptosis in vitro.{28253}
Brand:CaymanSKU:-Available on backorder
Transforming growth factor-β-activated kinase 1 (TAK-1) is a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family that activates JNK/p38 and NF-κB pro-inflammatory signaling pathways. (5Z)-7-Oxozeaenol is a natural resorcylic lactone derived from fungi that selectively inhibits purified TAK-1 (IC50 = 8.1 nM when co-expressed with the TAK-1-binding protein) without significantly affecting the kinase activities of other MAPKKK family members (IC50 = 411 nM for MEK1).{28252} In cells, (5Z)-7-Oxozeaenol is reported to irreversibly block IL-1-induced activation of TAK-1, NF-κB, and JNK/p38 with IC50 values of 65-83 nM.{28252} (5Z)-7-Oxozeaenol has also been shown to inhibit IL-1-induced COX-2 production in cells and to relieve ear swelling induced by picryl chloride in a mouse model of COX-2-mediated inflammation.{28252} This compound has been found to sensitize cells to TRAIL- and TNF-α-induced apoptosis in vitro.{28253}
Brand:CaymanSKU:-Available on backorder
(6aR,9R)-∆10-THC (exempt preparation) (Item No. 29780) is an analytical reference standard that is categorized as a synthetic cannabinoid.{51088} (6aR,9R)-∆10-THC is regulated as a Schedule I compound in the United States. (6aR,9R)-Δ10-THC (Item No. 29780) is provided as a DEA exempt preparation. This product is intended for research and forensic applications
Brand:CaymanSKU:29780 - 1 mgAvailable on backorder
(6aR,9S)-Δ10-THC (exempt preparation) (Item No. 29781) is an analytical reference standard categorized as a synthetic cannabinoid.{51088} (6aR,9S)-Δ10-THC is regulated as a Schedule I compound in the United States. (6aR,9S)-Δ10-THC (Item No. 29781) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
Brand:CaymanSKU:29781 - 1 mgAvailable on backorder
(6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.{29515} Its metabolites participate in the synthesis of thymidine for incorporation into DNA or the synthesis of purines, as well as in the formation of methionine, which can be converted to the ubiquitous methyl donor, S-adenosylmethionine (Item No. 13956).{29515} THFA has also been used to study the activation of metabolite-binding riboswitches.{29514}
Brand:CaymanSKU:20526 -Available on backorder
(6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.{29515} Its metabolites participate in the synthesis of thymidine for incorporation into DNA or the synthesis of purines, as well as in the formation of methionine, which can be converted to the ubiquitous methyl donor, S-adenosylmethionine (Item No. 13956).{29515} THFA has also been used to study the activation of metabolite-binding riboswitches.{29514}
Brand:CaymanSKU:20526 -Available on backorder
(6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.{29515} Its metabolites participate in the synthesis of thymidine for incorporation into DNA or the synthesis of purines, as well as in the formation of methionine, which can be converted to the ubiquitous methyl donor, S-adenosylmethionine (Item No. 13956).{29515} THFA has also been used to study the activation of metabolite-binding riboswitches.{29514}
Brand:CaymanSKU:20526 -Available on backorder
(6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.{29515} Its metabolites participate in the synthesis of thymidine for incorporation into DNA or the synthesis of purines, as well as in the formation of methionine, which can be converted to the ubiquitous methyl donor, S-adenosylmethionine (Item No. 13956).{29515} THFA has also been used to study the activation of metabolite-binding riboswitches.{29514}
Brand:CaymanSKU:20526 -Available on backorder
(6S)-Tetrahydrofolic acid is a diastereomer of tetrahydrofolic acid (Item No. 20526), a reduced form of folic acid that serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.{29515} (6S)-Tetrahydrofolic acid is 1,000-fold more active than the (6R) form at promoting the binding of fluorodeoxyuridylate to thymidylate synthase and 600-fold more active as a growth factor of P. cerevisiae.{32161} (6S)-Tetrahydrofolic acid also has a low affinity and high dissociation rate for folate-binding protein.{32160}
Brand:CaymanSKU:-Available on backorder
(6S)-Tetrahydrofolic acid is a diastereomer of tetrahydrofolic acid (Item No. 20526), a reduced form of folic acid that serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.{29515} (6S)-Tetrahydrofolic acid is 1,000-fold more active than the (6R) form at promoting the binding of fluorodeoxyuridylate to thymidylate synthase and 600-fold more active as a growth factor of P. cerevisiae.{32161} (6S)-Tetrahydrofolic acid also has a low affinity and high dissociation rate for folate-binding protein.{32160}
Brand:CaymanSKU:-Available on backorder
(6S)-Tetrahydrofolic acid is a diastereomer of tetrahydrofolic acid (Item No. 20526), a reduced form of folic acid that serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.{29515} (6S)-Tetrahydrofolic acid is 1,000-fold more active than the (6R) form at promoting the binding of fluorodeoxyuridylate to thymidylate synthase and 600-fold more active as a growth factor of P. cerevisiae.{32161} (6S)-Tetrahydrofolic acid also has a low affinity and high dissociation rate for folate-binding protein.{32160}
Brand:CaymanSKU:-Available on backorder
(Des-Arg9)-Bradykinin is an active metabolite of the endogenous vasodilator bradykinin (Item No. 15539) and a peptide agonist of the bradykinin B1 receptor.{49599,59178} It binds to bradykinin B1 and B2 receptors (Kis = 1.93 and 8.1 µM, respectively).{49601} (Des-Arg9)-Bradykinin is formed via carboxypeptidase-mediated cleavage of the bradykinin C-terminal arginine residue in plasma and tissues.{59178} It induces relaxation of precontracted isolated endothelium-denuded dog renal artery strips (pD2 = 8.6).{49603} (Des-Arg9)-Bradykinin decreases blood pressure in LPS-treated rabbits in a dose-dependent manner.{49600}
Brand:CaymanSKU:31136 - 10 mgAvailable on backorder
(Des-Arg9)-Bradykinin is an active metabolite of the endogenous vasodilator bradykinin (Item No. 15539) and a peptide agonist of the bradykinin B1 receptor.{49599,59178} It binds to bradykinin B1 and B2 receptors (Kis = 1.93 and 8.1 µM, respectively).{49601} (Des-Arg9)-Bradykinin is formed via carboxypeptidase-mediated cleavage of the bradykinin C-terminal arginine residue in plasma and tissues.{59178} It induces relaxation of precontracted isolated endothelium-denuded dog renal artery strips (pD2 = 8.6).{49603} (Des-Arg9)-Bradykinin decreases blood pressure in LPS-treated rabbits in a dose-dependent manner.{49600}
Brand:CaymanSKU:31136 - 25 mgAvailable on backorder
(Des-Arg9)-Bradykinin is an active metabolite of the endogenous vasodilator bradykinin (Item No. 15539) and a peptide agonist of the bradykinin B1 receptor.{49599,59178} It binds to bradykinin B1 and B2 receptors (Kis = 1.93 and 8.1 µM, respectively).{49601} (Des-Arg9)-Bradykinin is formed via carboxypeptidase-mediated cleavage of the bradykinin C-terminal arginine residue in plasma and tissues.{59178} It induces relaxation of precontracted isolated endothelium-denuded dog renal artery strips (pD2 = 8.6).{49603} (Des-Arg9)-Bradykinin decreases blood pressure in LPS-treated rabbits in a dose-dependent manner.{49600}
Brand:CaymanSKU:31136 - 5 mgAvailable on backorder
(Des-Arg9)-Bradykinin is an active metabolite of the endogenous vasodilator bradykinin (Item No. 15539) and a peptide agonist of the bradykinin B1 receptor.{49599,59178} It binds to bradykinin B1 and B2 receptors (Kis = 1.93 and 8.1 µM, respectively).{49601} (Des-Arg9)-Bradykinin is formed via carboxypeptidase-mediated cleavage of the bradykinin C-terminal arginine residue in plasma and tissues.{59178} It induces relaxation of precontracted isolated endothelium-denuded dog renal artery strips (pD2 = 8.6).{49603} (Des-Arg9)-Bradykinin decreases blood pressure in LPS-treated rabbits in a dose-dependent manner.{49600}
Brand:CaymanSKU:31136 - 50 mgAvailable on backorder
(E,Z)-2-propyl-2-Pentenoic acid is a bioactive metabolite of valproic acid (Item No. 13033) that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity and hepatotoxicity.{31715}
Brand:CaymanSKU:19591 -Available on backorder
(E,Z)-2-propyl-2-Pentenoic acid is a bioactive metabolite of valproic acid (Item No. 13033) that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity and hepatotoxicity.{31715}
Brand:CaymanSKU:19591 -Available on backorder
(E,Z)-2-propyl-2-Pentenoic acid is a bioactive metabolite of valproic acid (Item No. 13033) that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity and hepatotoxicity.{31715}
Brand:CaymanSKU:19591 -Available on backorder
(E,Z)-2-propyl-2-Pentenoic acid is a bioactive metabolite of valproic acid (Item No. 13033) that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity and hepatotoxicity.{31715}
Brand:CaymanSKU:19591 -Available on backorder
(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities.{43230,43231,43232} It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM).{43230} CSTMP reduces hydrogen peroxide-induced release of lactate dehydrogenase (LDH) in and increases viability of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner via inhibition of apoptosis.{43231} It reverses hydrogen peroxide-induced release of malondialdehyde (MDA) and decreases in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities as well as increases constitutive nitric oxide synthase (cNOS) activity and nitric oxide (NO) production in HUVECs. CSTMP also induces cell death of A549 non-small cell lung cancer (NSCLC) cells in an IRE1α-dependent manner through induction of IRE1α-TRAF2-ASK1 complex-mediated endoplasmic reticulum (ER) stress and mitochondrial apoptosis.{43232}
Brand:CaymanSKU:9003202 - 1 mgAvailable on backorder
(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities.{43230,43231,43232} It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM).{43230} CSTMP reduces hydrogen peroxide-induced release of lactate dehydrogenase (LDH) in and increases viability of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner via inhibition of apoptosis.{43231} It reverses hydrogen peroxide-induced release of malondialdehyde (MDA) and decreases in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities as well as increases constitutive nitric oxide synthase (cNOS) activity and nitric oxide (NO) production in HUVECs. CSTMP also induces cell death of A549 non-small cell lung cancer (NSCLC) cells in an IRE1α-dependent manner through induction of IRE1α-TRAF2-ASK1 complex-mediated endoplasmic reticulum (ER) stress and mitochondrial apoptosis.{43232}
Brand:CaymanSKU:9003202 - 10 mgAvailable on backorder
(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities.{43230,43231,43232} It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM).{43230} CSTMP reduces hydrogen peroxide-induced release of lactate dehydrogenase (LDH) in and increases viability of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner via inhibition of apoptosis.{43231} It reverses hydrogen peroxide-induced release of malondialdehyde (MDA) and decreases in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities as well as increases constitutive nitric oxide synthase (cNOS) activity and nitric oxide (NO) production in HUVECs. CSTMP also induces cell death of A549 non-small cell lung cancer (NSCLC) cells in an IRE1α-dependent manner through induction of IRE1α-TRAF2-ASK1 complex-mediated endoplasmic reticulum (ER) stress and mitochondrial apoptosis.{43232}
Brand:CaymanSKU:9003202 - 25 mgAvailable on backorder
(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities.{43230,43231,43232} It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM).{43230} CSTMP reduces hydrogen peroxide-induced release of lactate dehydrogenase (LDH) in and increases viability of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner via inhibition of apoptosis.{43231} It reverses hydrogen peroxide-induced release of malondialdehyde (MDA) and decreases in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities as well as increases constitutive nitric oxide synthase (cNOS) activity and nitric oxide (NO) production in HUVECs. CSTMP also induces cell death of A549 non-small cell lung cancer (NSCLC) cells in an IRE1α-dependent manner through induction of IRE1α-TRAF2-ASK1 complex-mediated endoplasmic reticulum (ER) stress and mitochondrial apoptosis.{43232}
Brand:CaymanSKU:9003202 - 5 mgAvailable on backorder
Sphingosine-1-phosphate (S1P), a bioactive lipid involved in many signaling processes, is irreversibly degraded by the membrane-bound S1P lyase. (E)-2-Hexadecenal is a sphingolipid degradation product resulting from the action of S1P lyase. It can be further oxidized to (2E)-hexadecenoic acid by long-chain fatty aldehyde dehydrogenase prior to activation via coupling to coenzyme A. (E)-2-Hexadecenal has been shown to induce cytoskeletal reorganization that results in cell rounding, detachment, activation of downstream JNK targets, and eventual apoptosis in various cell types.{28538} It reacts readily with deoxyguanosine and DNA to form aldehyde-derived DNA adducts.{28539}
Brand:CaymanSKU:-Available on backorder
Sphingosine-1-phosphate (S1P), a bioactive lipid involved in many signaling processes, is irreversibly degraded by the membrane-bound S1P lyase. (E)-2-Hexadecenal is a sphingolipid degradation product resulting from the action of S1P lyase. It can be further oxidized to (2E)-hexadecenoic acid by long-chain fatty aldehyde dehydrogenase prior to activation via coupling to coenzyme A. (E)-2-Hexadecenal has been shown to induce cytoskeletal reorganization that results in cell rounding, detachment, activation of downstream JNK targets, and eventual apoptosis in various cell types.{28538} It reacts readily with deoxyguanosine and DNA to form aldehyde-derived DNA adducts.{28539}
Brand:CaymanSKU:-Available on backorder
Sphingosine-1-phosphate (S1P), a bioactive lipid involved in many signaling processes, is irreversibly degraded by the membrane-bound S1P lyase. (E)-2-Hexadecenal is a sphingolipid degradation product resulting from the action of S1P lyase. It can be further oxidized to (2E)-hexadecenoic acid by long-chain fatty aldehyde dehydrogenase prior to activation via coupling to coenzyme A. (E)-2-Hexadecenal has been shown to induce cytoskeletal reorganization that results in cell rounding, detachment, activation of downstream JNK targets, and eventual apoptosis in various cell types.{28538} It reacts readily with deoxyguanosine and DNA to form aldehyde-derived DNA adducts.{28539}
Brand:CaymanSKU:-Available on backorder
(E)-2-Hexadecenal alkyne is an alkyne version of the sphingolipid degradation product (E)-2-hexadecenal (Item No. 17566) that can be used as a click chemistry probe.{33406} (E)-2-Hexadecenal has been shown to induce cytoskeletal reorganization that results in cell rounding, detachment, activation of downstream JNK targets, and eventual apoptosis in various cell types.{28538} It reacts readily with deoxyguanosine and DNA to form aldehyde-derived DNA adducts.{28539}
Brand:CaymanSKU:20714 -Available on backorder
(E)-2-Hexadecenal alkyne is an alkyne version of the sphingolipid degradation product (E)-2-hexadecenal (Item No. 17566) that can be used as a click chemistry probe.{33406} (E)-2-Hexadecenal has been shown to induce cytoskeletal reorganization that results in cell rounding, detachment, activation of downstream JNK targets, and eventual apoptosis in various cell types.{28538} It reacts readily with deoxyguanosine and DNA to form aldehyde-derived DNA adducts.{28539}
Brand:CaymanSKU:20714 -Available on backorder
(E)-2-Hexadecenal alkyne is an alkyne version of the sphingolipid degradation product (E)-2-hexadecenal (Item No. 17566) that can be used as a click chemistry probe.{33406} (E)-2-Hexadecenal has been shown to induce cytoskeletal reorganization that results in cell rounding, detachment, activation of downstream JNK targets, and eventual apoptosis in various cell types.{28538} It reacts readily with deoxyguanosine and DNA to form aldehyde-derived DNA adducts.{28539}
Brand:CaymanSKU:20714 -Available on backorder
(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo.{42576,42577,42575} BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner.{42576,42578} It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil (5-FU; Item No. 14416) in a P388 murine leukemia model when administered at a dose of 200 µmol/kg, increasing survival time.{42578}
Brand:CaymanSKU:21030 -Out of stock
(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo.{42576,42577,42575} BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner.{42576,42578} It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil (5-FU; Item No. 14416) in a P388 murine leukemia model when administered at a dose of 200 µmol/kg, increasing survival time.{42578}
Brand:CaymanSKU:21030 -Out of stock
(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo.{42576,42577,42575} BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner.{42576,42578} It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil (5-FU; Item No. 14416) in a P388 murine leukemia model when administered at a dose of 200 µmol/kg, increasing survival time.{42578}
Brand:CaymanSKU:21030 -Out of stock
(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo.{42576,42577,42575} BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner.{42576,42578} It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil (5-FU; Item No. 14416) in a P388 murine leukemia model when administered at a dose of 200 µmol/kg, increasing survival time.{42578}
Brand:CaymanSKU:21030 -Out of stock
(E)-8-Methyl-6-nonenoic acid is a potential thermal degradant of capsaicin (Item No. 92350) with possible mutagenic effects.{10293,10294}
Brand:CaymanSKU:-Out of stock
(E)-8-Methyl-6-nonenoic acid is a potential thermal degradant of capsaicin (Item No. 92350) with possible mutagenic effects.{10293,10294}
Brand:CaymanSKU:-Out of stock
(E)-8-Methyl-6-nonenoic acid is a potential thermal degradant of capsaicin (Item No. 92350) with possible mutagenic effects.{10293,10294}
Brand:CaymanSKU:-Out of stock
(E)-8-Methyl-6-nonenoic acid is a potential thermal degradant of capsaicin (Item No. 92350) with possible mutagenic effects.{10293,10294}
Brand:CaymanSKU:-Out of stock
(E)-Anethol is a phenylpropanoid that has been found in P. anisum seed oil and has antifungal and antioxidant activity.{54031,54032,54033} It is active against fermentatively growing S. cerevisiae under hypoxic, but not normoxic, conditions (MIC = 100 µg/ml), and against C. parapsilosis when used at a concentration of 15% w/w.{54032,54033} (E)-Anethol has antioxidant activity in a Trolox equivalent antioxidant capacity (TEAC) assay but does not scavenge 2,2-diphenyl-1-picrylhydrazel (DPPH) radicals in a cell-free assay.{54033}
Brand:CaymanSKU:29862 - 100 gAvailable on backorder
(E)-Anethol is a phenylpropanoid that has been found in P. anisum seed oil and has antifungal and antioxidant activity.{54031,54032,54033} It is active against fermentatively growing S. cerevisiae under hypoxic, but not normoxic, conditions (MIC = 100 µg/ml), and against C. parapsilosis when used at a concentration of 15% w/w.{54032,54033} (E)-Anethol has antioxidant activity in a Trolox equivalent antioxidant capacity (TEAC) assay but does not scavenge 2,2-diphenyl-1-picrylhydrazel (DPPH) radicals in a cell-free assay.{54033}
Brand:CaymanSKU:29862 - 250 gAvailable on backorder
(E)-Anethol is a phenylpropanoid that has been found in P. anisum seed oil and has antifungal and antioxidant activity.{54031,54032,54033} It is active against fermentatively growing S. cerevisiae under hypoxic, but not normoxic, conditions (MIC = 100 µg/ml), and against C. parapsilosis when used at a concentration of 15% w/w.{54032,54033} (E)-Anethol has antioxidant activity in a Trolox equivalent antioxidant capacity (TEAC) assay but does not scavenge 2,2-diphenyl-1-picrylhydrazel (DPPH) radicals in a cell-free assay.{54033}
Brand:CaymanSKU:29862 - 50 gAvailable on backorder
Synthetic and natural alkyl phosphates, also known as phosphoantigens, stimulate the proliferation of γδ-T lymphocytes.{17387} Isopentenyl pyrophosphate, and related derivatives including (E)-hydroxy-dimethyl-allyl pyrophosphate ((E)-HDMAPP), are particularly effective activators of γδ-T cells.{17389}{17388} (E)-C-HDMAPP is the pyrophosphonate form of (E)-HDMAPP. The pyrophosphonate moiety in (E)-C-HDMAPP is much less susceptible to chemical or enzymatic hydrolysis than its pyrophosphate counterpart. As a result, (E)-C-HDMAPP is much more stable in solution and in vascular circulation.{16651} (E)-C-HDMAPP possesses comparable activity to (E)-HDMAPP, which is the most potent of the isoprenoid phosphoantigens. (E)-C-HDMAPP stimulates the synthesis of tumor necrosis factor (TNF-α) by γδ-T lymphocytes with an IC50 value of 0.91 nM.{16651} (E)-C-HDMAPP also significantly increases the number of circulating γδ-T cells in vivo, in cynomolgus monkeys.{16651}
Brand:CaymanSKU:- Synthetic and natural alkyl phosphates, also known as phosphoantigens, stimulate the proliferation of γδ-T lymphocytes.{17387} Isopentenyl pyrophosphate, and related derivatives including (E)-hydroxy-dimethyl-allyl pyrophosphate ((E)-HDMAPP), are particularly effective activators of γδ-T cells.{17389}{17388} (E)-C-HDMAPP is the pyrophosphonate form of (E)-HDMAPP. The pyrophosphonate moiety in (E)-C-HDMAPP is much less susceptible to chemical or enzymatic hydrolysis than its pyrophosphate counterpart. As a result, (E)-C-HDMAPP is much more stable in solution and in vascular circulation.{16651} (E)-C-HDMAPP possesses comparable activity to (E)-HDMAPP, which is the most potent of the isoprenoid phosphoantigens. (E)-C-HDMAPP stimulates the synthesis of tumor necrosis factor (TNF-α) by γδ-T lymphocytes with an IC50 value of 0.91 nM.{16651} (E)-C-HDMAPP also significantly increases the number of circulating γδ-T cells in vivo, in cynomolgus monkeys.{16651}
Brand:CaymanSKU:- Synthetic and natural alkyl phosphates, also known as phosphoantigens, stimulate the proliferation of γδ-T lymphocytes.{17387} Isopentenyl pyrophosphate, and related derivatives including (E)-hydroxy-dimethyl-allyl pyrophosphate ((E)-HDMAPP), are particularly effective activators of γδ-T cells.{17389}{17388} (E)-C-HDMAPP is the pyrophosphonate form of (E)-HDMAPP. The pyrophosphonate moiety in (E)-C-HDMAPP is much less susceptible to chemical or enzymatic hydrolysis than its pyrophosphate counterpart. As a result, (E)-C-HDMAPP is much more stable in solution and in vascular circulation.{16651} (E)-C-HDMAPP possesses comparable activity to (E)-HDMAPP, which is the most potent of the isoprenoid phosphoantigens. (E)-C-HDMAPP stimulates the synthesis of tumor necrosis factor (TNF-α) by γδ-T lymphocytes with an IC50 value of 0.91 nM.{16651} (E)-C-HDMAPP also significantly increases the number of circulating γδ-T cells in vivo, in cynomolgus monkeys.{16651}
Brand:CaymanSKU:- Synthetic and natural alkyl phosphates, also known as phosphoantigens, stimulate the proliferation of γδ-T lymphocytes.{17387} Isopentenyl pyrophosphate, and related derivatives including (E)-hydroxy-dimethyl-allyl pyrophosphate ((E)-HDMAPP), are particularly effective activators of γδ-T cells.{17389}{17388} (E)-C-HDMAPP is the pyrophosphonate form of (E)-HDMAPP. The pyrophosphonate moiety in (E)-C-HDMAPP is much less susceptible to chemical or enzymatic hydrolysis than its pyrophosphate counterpart. As a result, (E)-C-HDMAPP is much more stable in solution and in vascular circulation.{16651} (E)-C-HDMAPP possesses comparable activity to (E)-HDMAPP, which is the most potent of the isoprenoid phosphoantigens. (E)-C-HDMAPP stimulates the synthesis of tumor necrosis factor (TNF-α) by γδ-T lymphocytes with an IC50 value of 0.91 nM.{16651} (E)-C-HDMAPP also significantly increases the number of circulating γδ-T cells in vivo, in cynomolgus monkeys.{16651}
Brand:CaymanSKU:-
(E)-Fenpyroximate is a phenoxypyrazole acaricide.{41957} It is lethal to mobile adult phytophagous mites of the genera Tetranychidae, Eriophyidae, and Tarsonemidae and inhibits molting at immature stages. (E)-Fenpyroximate reduces the number of eggs laid per female and is lethal to female A. swirskii predatory mites.{41958} It is also selectively lethal to worker over queen honey bees (LD50s = 30 and >1,620 μg/g, respectively).{41959} (E)-Fenpyroximate induces cell death in marine flounder (P. olivaceus) gill cells (IC50 = 800-1,250 nM) and is lethal to adult living flounder (LC50 = 28.84 nM in seawater).{41960}
Brand:CaymanSKU:25625 - 100 mgAvailable on backorder
(E)-Fenpyroximate is a phenoxypyrazole acaricide.{41957} It is lethal to mobile adult phytophagous mites of the genera Tetranychidae, Eriophyidae, and Tarsonemidae and inhibits molting at immature stages. (E)-Fenpyroximate reduces the number of eggs laid per female and is lethal to female A. swirskii predatory mites.{41958} It is also selectively lethal to worker over queen honey bees (LD50s = 30 and >1,620 μg/g, respectively).{41959} (E)-Fenpyroximate induces cell death in marine flounder (P. olivaceus) gill cells (IC50 = 800-1,250 nM) and is lethal to adult living flounder (LC50 = 28.84 nM in seawater).{41960}
Brand:CaymanSKU:25625 - 50 mgAvailable on backorder
Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.{10943} They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.{14024,16793} Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.Guggulsterone, derived from resin of the guggul tree, is a competitive antagonist of FXR both in vitro and in vivo.{9823} The cis stereoisomer of guggulsterone, (E)-guggulsterone, decreases chenodeoxycholic acid (CDCA)-induced FXR activation with an IC50 value of 15 µM. {17615, 17566} By inhibiting CDCA-induced transactivation of FXR, guggulsterone lowers low-density lipoprotein cholesterol and triglyceride levels in rodents fed a high cholesterol diet.{9823}
Brand:CaymanSKU:10011296 - 1 mgAvailable on backorder
Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.{10943} They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.{14024,16793} Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.Guggulsterone, derived from resin of the guggul tree, is a competitive antagonist of FXR both in vitro and in vivo.{9823} The cis stereoisomer of guggulsterone, (E)-guggulsterone, decreases chenodeoxycholic acid (CDCA)-induced FXR activation with an IC50 value of 15 µM. {17615, 17566} By inhibiting CDCA-induced transactivation of FXR, guggulsterone lowers low-density lipoprotein cholesterol and triglyceride levels in rodents fed a high cholesterol diet.{9823}
Brand:CaymanSKU:10011296 - 10 mgAvailable on backorder
Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.{10943} They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.{14024,16793} Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.Guggulsterone, derived from resin of the guggul tree, is a competitive antagonist of FXR both in vitro and in vivo.{9823} The cis stereoisomer of guggulsterone, (E)-guggulsterone, decreases chenodeoxycholic acid (CDCA)-induced FXR activation with an IC50 value of 15 µM. {17615, 17566} By inhibiting CDCA-induced transactivation of FXR, guggulsterone lowers low-density lipoprotein cholesterol and triglyceride levels in rodents fed a high cholesterol diet.{9823}
Brand:CaymanSKU:10011296 - 25 mgAvailable on backorder
Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.{10943} They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.{14024,16793} Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.Guggulsterone, derived from resin of the guggul tree, is a competitive antagonist of FXR both in vitro and in vivo.{9823} The cis stereoisomer of guggulsterone, (E)-guggulsterone, decreases chenodeoxycholic acid (CDCA)-induced FXR activation with an IC50 value of 15 µM. {17615, 17566} By inhibiting CDCA-induced transactivation of FXR, guggulsterone lowers low-density lipoprotein cholesterol and triglyceride levels in rodents fed a high cholesterol diet.{9823}
Brand:CaymanSKU:10011296 - 5 mgAvailable on backorder