Cayman
Showing 11551–11700 of 45550 results
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Benserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC), an enzyme that has dopamine decarboxylase activity.{32006,32007} It is also unable to cross the blood-brain barrier. As a result, benserazide blocks the conversion of L-DOPA (Item No. 13248) to dopamine by AADC in the peripheral circulatory system. Benserazide is often combined with L-DOPA in patients with Parkinson’s disease.{32008}
Brand:CaymanSKU:20298 -Available on backorder
Bentamapimod is an orally bioavailable inhibitor of Jun kinases (JNKs), with IC50 values for JNK1, JNK2, and JNK3 of 80, 90, and 230 nM, respectively.{33921,33920} It is selective for JNKs over a panel of 25 related kinases.{33921} Bentamapimod induces regression of endometriotic lesions without suppressing estrogen action in animal models of endometriosis.{33922,33924} It blocks proliferation and induces apoptosis of T cells in vitro and inhibits cancer stem cell survival, self-renewal, and tumor-initiating capacity in vitro and in mice.{33920,33923}
Brand:CaymanSKU:21482 -Out of stock
Bentamapimod is an orally bioavailable inhibitor of Jun kinases (JNKs), with IC50 values for JNK1, JNK2, and JNK3 of 80, 90, and 230 nM, respectively.{33921,33920} It is selective for JNKs over a panel of 25 related kinases.{33921} Bentamapimod induces regression of endometriotic lesions without suppressing estrogen action in animal models of endometriosis.{33922,33924} It blocks proliferation and induces apoptosis of T cells in vitro and inhibits cancer stem cell survival, self-renewal, and tumor-initiating capacity in vitro and in mice.{33920,33923}
Brand:CaymanSKU:21482 -Out of stock
Bentamapimod is an orally bioavailable inhibitor of Jun kinases (JNKs), with IC50 values for JNK1, JNK2, and JNK3 of 80, 90, and 230 nM, respectively.{33921,33920} It is selective for JNKs over a panel of 25 related kinases.{33921} Bentamapimod induces regression of endometriotic lesions without suppressing estrogen action in animal models of endometriosis.{33922,33924} It blocks proliferation and induces apoptosis of T cells in vitro and inhibits cancer stem cell survival, self-renewal, and tumor-initiating capacity in vitro and in mice.{33920,33923}
Brand:CaymanSKU:21482 -Out of stock
Bentamapimod is an orally bioavailable inhibitor of Jun kinases (JNKs), with IC50 values for JNK1, JNK2, and JNK3 of 80, 90, and 230 nM, respectively.{33921,33920} It is selective for JNKs over a panel of 25 related kinases.{33921} Bentamapimod induces regression of endometriotic lesions without suppressing estrogen action in animal models of endometriosis.{33922,33924} It blocks proliferation and induces apoptosis of T cells in vitro and inhibits cancer stem cell survival, self-renewal, and tumor-initiating capacity in vitro and in mice.{33920,33923}
Brand:CaymanSKU:21482 -Out of stock
Bentazepam (Item No. 27748) is an analytical reference standard categorized as a benzodiazepine.{46401} This product is intended for research and forensic applications.
Brand:CaymanSKU:27748 - 1 mgAvailable on backorder
Bentazepam (Item No. 27748) is an analytical reference standard categorized as a benzodiazepine.{46401} This product is intended for research and forensic applications.
Brand:CaymanSKU:27748 - 5 mgAvailable on backorder
Benzamidine is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Kis = 35, 350, and 220 µM, respectively).{33232,33233,33235} In addition to its use as a general serine protease inhibitor, benzamidine is used, when immobilized, to purify novel proteases.{33234,33236}
Brand:CaymanSKU:20651 -Available on backorder
Benzamidine is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Kis = 35, 350, and 220 µM, respectively).{33232,33233,33235} In addition to its use as a general serine protease inhibitor, benzamidine is used, when immobilized, to purify novel proteases.{33234,33236}
Brand:CaymanSKU:20651 -Available on backorder
Benzamidine is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Kis = 35, 350, and 220 µM, respectively).{33232,33233,33235} In addition to its use as a general serine protease inhibitor, benzamidine is used, when immobilized, to purify novel proteases.{33234,33236}
Brand:CaymanSKU:20651 -Available on backorder
Benzamidine is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Kis = 35, 350, and 220 µM, respectively).{33232,33233,33235} In addition to its use as a general serine protease inhibitor, benzamidine is used, when immobilized, to purify novel proteases.{33234,33236}
Brand:CaymanSKU:20651 -Available on backorder
Benzamil is a derivative of amiloride (Item No. 14409).{48507} Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles. It is also an inhibitor of the Na+/Ca2+ exchanger (NCX) that inhibits the cytosolic calcium response to extracellular sodium depletion in mouse podocytes (IC50 = ~100 nM).{48508} Benzamil inhibits transient receptor potential polycystin-L (TRPP3; IC50 = 1.1 μM), a member of the TRP superfamily of cation channels.{24798}
Brand:CaymanSKU:- Benzamil is a derivative of amiloride (Item No. 14409).{48507} Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles. It is also an inhibitor of the Na+/Ca2+ exchanger (NCX) that inhibits the cytosolic calcium response to extracellular sodium depletion in mouse podocytes (IC50 = ~100 nM).{48508} Benzamil inhibits transient receptor potential polycystin-L (TRPP3; IC50 = 1.1 μM), a member of the TRP superfamily of cation channels.{24798}
Brand:CaymanSKU:-
Benzbromarone is an inhibitor of the urate anion transporter (IC50 = 0.3 µM for hURAT1) that prevents renal urate resorption.{31716} It also potently inhibits CYP2C9 (Ki = 20 nM), a major cytochrome P450 enzyme involved in the metabolic clearance of a wide range of therapeutic agents.{24422} Several analogs of benzabromarone have been developed with varying binding affinities to CYP2C9 in order to study adverse drug-drug interactions.{24411}
Brand:CaymanSKU:19768 -Available on backorder
Benzbromarone is an inhibitor of the urate anion transporter (IC50 = 0.3 µM for hURAT1) that prevents renal urate resorption.{31716} It also potently inhibits CYP2C9 (Ki = 20 nM), a major cytochrome P450 enzyme involved in the metabolic clearance of a wide range of therapeutic agents.{24422} Several analogs of benzabromarone have been developed with varying binding affinities to CYP2C9 in order to study adverse drug-drug interactions.{24411}
Brand:CaymanSKU:19768 -Available on backorder
Benzbromarone is an inhibitor of the urate anion transporter (IC50 = 0.3 µM for hURAT1) that prevents renal urate resorption.{31716} It also potently inhibits CYP2C9 (Ki = 20 nM), a major cytochrome P450 enzyme involved in the metabolic clearance of a wide range of therapeutic agents.{24422} Several analogs of benzabromarone have been developed with varying binding affinities to CYP2C9 in order to study adverse drug-drug interactions.{24411}
Brand:CaymanSKU:19768 -Available on backorder
4-Methylmethcathinone (also known as Mephedrone) is a stimulatory designer drug found in bath salts and similar products.{19193,19508,20369} Benzedrone is an analog of mephedrone characterized by the replacement of the amino methyl group with a benzyl moiety. The physiological and toxicological properties of this compound are unknown. This product is intended for forensic and research applications.
Brand:CaymanSKU:11915 - 10 mgAvailable on backorder
4-Methylmethcathinone (also known as Mephedrone) is a stimulatory designer drug found in bath salts and similar products.{19193,19508,20369} Benzedrone is an analog of mephedrone characterized by the replacement of the amino methyl group with a benzyl moiety. The physiological and toxicological properties of this compound are unknown. This product is intended for forensic and research applications.
Brand:CaymanSKU:11915 - 5 mgAvailable on backorder
4-Methylmethcathinone (also known as Mephedrone) is a stimulatory designer drug found in bath salts and similar products.{19193,19508,20369} Benzedrone is an analog of mephedrone characterized by the replacement of the amino methyl group with a benzyl moiety. The physiological and toxicological properties of this compound are unknown. This product is intended for forensic and research applications.
Brand:CaymanSKU:11915 - 50 mgAvailable on backorder
Benzisoxazole Hsp90 inhibitor is an inhibitor of heat shock protein 90 (Hsp90; IC50 = 30 nM in a fluorescence polarization assay).{15810} It is selective for Hsp90 over a panel of kinases (IC50s = >20 µM). Benzisoxazole Hsp90 inhibitor inhibits the proliferation of HCT116, SK-BR-3, LNCaP, DU145, and H157 cancer cells (IC50s = 0.28, 0.37, 0.17, 0.29, and 0.23 µM, respectively). It also induces degradation of the Hsp90 targets HER2 and the androgen receptor in SK-BR-3 and LNCaP cells, respectively, with an IC50 value of 0.33 µM for both.
Brand:CaymanSKU:10012694 - 1 mgAvailable on backorder
Benzisoxazole Hsp90 inhibitor is an inhibitor of heat shock protein 90 (Hsp90; IC50 = 30 nM in a fluorescence polarization assay).{15810} It is selective for Hsp90 over a panel of kinases (IC50s = >20 µM). Benzisoxazole Hsp90 inhibitor inhibits the proliferation of HCT116, SK-BR-3, LNCaP, DU145, and H157 cancer cells (IC50s = 0.28, 0.37, 0.17, 0.29, and 0.23 µM, respectively). It also induces degradation of the Hsp90 targets HER2 and the androgen receptor in SK-BR-3 and LNCaP cells, respectively, with an IC50 value of 0.33 µM for both.
Brand:CaymanSKU:10012694 - 10 mgAvailable on backorder
Benzisoxazole Hsp90 inhibitor is an inhibitor of heat shock protein 90 (Hsp90; IC50 = 30 nM in a fluorescence polarization assay).{15810} It is selective for Hsp90 over a panel of kinases (IC50s = >20 µM). Benzisoxazole Hsp90 inhibitor inhibits the proliferation of HCT116, SK-BR-3, LNCaP, DU145, and H157 cancer cells (IC50s = 0.28, 0.37, 0.17, 0.29, and 0.23 µM, respectively). It also induces degradation of the Hsp90 targets HER2 and the androgen receptor in SK-BR-3 and LNCaP cells, respectively, with an IC50 value of 0.33 µM for both.
Brand:CaymanSKU:10012694 - 5 mgAvailable on backorder
Benznidazole is an orally bioavailable antiprotozoal agent.{48626} It is a 2-nitroimidazole prodrug that becomes active when the nitro group is reduced within the parasite.{48630} It inhibits the growth of the parasites T. cruzi, T. vaginalis, G. lamblia, and E. histolytica (IC50s = 8.1, 18.62, 22.58, and 4.27 μM, respectively).{48627,48628} It also inhibits clonogenic growth of human C33A cervical and KNS42 glioblastoma cancer cells under hypoxic, but not normoxic, conditions when used at a concentration of 100 μM.{48629} Benznidazole (100 mg/kg per day) decreases T. cruzi blood parasitemia to below detectable levels in a mouse model of chronic stable Chagas disease.{48626} Formulations containing benznidazole have been used in the treatment of Chagas disease caused by T. cruzi.
Brand:CaymanSKU:29090 - 100 mgAvailable on backorder
Benznidazole is an orally bioavailable antiprotozoal agent.{48626} It is a 2-nitroimidazole prodrug that becomes active when the nitro group is reduced within the parasite.{48630} It inhibits the growth of the parasites T. cruzi, T. vaginalis, G. lamblia, and E. histolytica (IC50s = 8.1, 18.62, 22.58, and 4.27 μM, respectively).{48627,48628} It also inhibits clonogenic growth of human C33A cervical and KNS42 glioblastoma cancer cells under hypoxic, but not normoxic, conditions when used at a concentration of 100 μM.{48629} Benznidazole (100 mg/kg per day) decreases T. cruzi blood parasitemia to below detectable levels in a mouse model of chronic stable Chagas disease.{48626} Formulations containing benznidazole have been used in the treatment of Chagas disease caused by T. cruzi.
Brand:CaymanSKU:29090 - 25 mgAvailable on backorder
Benznidazole is an orally bioavailable antiprotozoal agent.{48626} It is a 2-nitroimidazole prodrug that becomes active when the nitro group is reduced within the parasite.{48630} It inhibits the growth of the parasites T. cruzi, T. vaginalis, G. lamblia, and E. histolytica (IC50s = 8.1, 18.62, 22.58, and 4.27 μM, respectively).{48627,48628} It also inhibits clonogenic growth of human C33A cervical and KNS42 glioblastoma cancer cells under hypoxic, but not normoxic, conditions when used at a concentration of 100 μM.{48629} Benznidazole (100 mg/kg per day) decreases T. cruzi blood parasitemia to below detectable levels in a mouse model of chronic stable Chagas disease.{48626} Formulations containing benznidazole have been used in the treatment of Chagas disease caused by T. cruzi.
Brand:CaymanSKU:29090 - 250 mgAvailable on backorder
Benznidazole is an orally bioavailable antiprotozoal agent.{48626} It is a 2-nitroimidazole prodrug that becomes active when the nitro group is reduced within the parasite.{48630} It inhibits the growth of the parasites T. cruzi, T. vaginalis, G. lamblia, and E. histolytica (IC50s = 8.1, 18.62, 22.58, and 4.27 μM, respectively).{48627,48628} It also inhibits clonogenic growth of human C33A cervical and KNS42 glioblastoma cancer cells under hypoxic, but not normoxic, conditions when used at a concentration of 100 μM.{48629} Benznidazole (100 mg/kg per day) decreases T. cruzi blood parasitemia to below detectable levels in a mouse model of chronic stable Chagas disease.{48626} Formulations containing benznidazole have been used in the treatment of Chagas disease caused by T. cruzi.
Brand:CaymanSKU:29090 - 50 mgAvailable on backorder
Benzocaine (Item No. 20132) is an analytical reference standard that is categorized as an adulterant. It is commonly used as a topical anesthetic.{31800} Benzocaine is also found as an adulterant in cocaine (Item Nos. 16186 | ISO60176).{31797,31798,31799,31801} This product is intended for research and forensic applications.
Brand:CaymanSKU:20132 -Available on backorder
Benzocaine (Item No. 20132) is an analytical reference standard that is categorized as an adulterant. It is commonly used as a topical anesthetic.{31800} Benzocaine is also found as an adulterant in cocaine (Item Nos. 16186 | ISO60176).{31797,31798,31799,31801} This product is intended for research and forensic applications.
Brand:CaymanSKU:20132 -Available on backorder
Cayman’s Benzodiazepine ELISA Kit is a competitive assay that can be used for quantification of benzodiazepines in plasma, serum, and urine. The assay has a range of 0.041-25 ng/ml with a midpoint of approximately 1.3 ng/ml (50% B/B0) and a sensitivity (80% B/B0) of approximately 0.3 ng/ml.
Brand:CaymanSKU:501800 - 96 solid wellAvailable on backorder
Cayman’s Benzodiazepine ELISA Kit is a competitive assay that can be used for quantification of benzodiazepines in plasma, serum, and urine. The assay has a range of 0.041-25 ng/ml with a midpoint of approximately 1.3 ng/ml (50% B/B0) and a sensitivity (80% B/B0) of approximately 0.3 ng/ml.
Brand:CaymanSKU:501800 - 96 strip wellAvailable on backorder
Benzodiazepine ELISA Standard has been tested and formulated to work exclusively with Cayman’s Benzodiazepine ELISA Kit (Item No. 501800). Please visit Benzodiazepine ELISA Kit (Item No. 501800) for the kit protocol, procedures, and product handling.
Brand:CaymanSKU:401804 - 1.25 µgAvailable on backorder
Benzomalvin A is a fungal metabolite produced by Penicillium.{43022,38039} It inhibits yeast α-glucosidase in vitro (IC50 = 383.2 μM).{43022} In vivo, benzomalvin A (3.1-31.6 mg/kg) decreases plasma glucose levels in mice following administration of sucrose. It also decreases the plasma glucose postprandial peak in nicotinamide-streptozotocin-induced hyperglycemic mice when administered at a dose of 10 mg/kg. Benzomalvin A also acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P (Item No. 24035) to guinea pig, rat, and human NK1 (Kis = 12, 42, and 43 μM, respectively).{38039}
Brand:CaymanSKU:25016 - 1 mgAvailable on backorder
Benzomalvin A is a fungal metabolite produced by Penicillium.{43022,38039} It inhibits yeast α-glucosidase in vitro (IC50 = 383.2 μM).{43022} In vivo, benzomalvin A (3.1-31.6 mg/kg) decreases plasma glucose levels in mice following administration of sucrose. It also decreases the plasma glucose postprandial peak in nicotinamide-streptozotocin-induced hyperglycemic mice when administered at a dose of 10 mg/kg. Benzomalvin A also acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P (Item No. 24035) to guinea pig, rat, and human NK1 (Kis = 12, 42, and 43 μM, respectively).{38039}
Brand:CaymanSKU:25016 - 5 mgAvailable on backorder
Benzomalvin B is a fungal metabolite originally isolated from Penicillium.{38039} It acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P (Item No. 24035) by 24% in vitro when used at a concentration of 100 μg/ml.
Brand:CaymanSKU:25088 - 1 mgAvailable on backorder
Benzomalvin B is a fungal metabolite originally isolated from Penicillium.{38039} It acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P (Item No. 24035) by 24% in vitro when used at a concentration of 100 μg/ml.
Brand:CaymanSKU:25088 - 5 mgAvailable on backorder
Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 µg/ml in vitro.{38039} It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC50 value of 130 µM for recombinant IDO.{38038} It was isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.
Brand:CaymanSKU:22064 -Out of stock
Benzonatate is a reversible voltage-gated sodium channel blocker.{37382} It blocks Nav1.7 currents in a concentration- and voltage-dependent manner (IC50s = 5.9 and 1.4 μM at holding potentials of -100 and -70 mV, respectively) and inhibits action potential firing in catecholamine A differentiated (CAD) cells. Benzonatate also blocks 80% of Nav1.3 currents in N1E-115 cells when used at a concentration of 100 μM. In vivo, benzonatate (0.85 mg/min) reduces the frequency, but has no effect on the amplitude, of the cough reflex in anesthetized dogs.{37383} Formulations containing benzonatate have been used as antitussive agents for the treatment of coughs.
Brand:CaymanSKU:23936 - 1 mgAvailable on backorder
Benzonatate is a reversible voltage-gated sodium channel blocker.{37382} It blocks Nav1.7 currents in a concentration- and voltage-dependent manner (IC50s = 5.9 and 1.4 μM at holding potentials of -100 and -70 mV, respectively) and inhibits action potential firing in catecholamine A differentiated (CAD) cells. Benzonatate also blocks 80% of Nav1.3 currents in N1E-115 cells when used at a concentration of 100 μM. In vivo, benzonatate (0.85 mg/min) reduces the frequency, but has no effect on the amplitude, of the cough reflex in anesthetized dogs.{37383} Formulations containing benzonatate have been used as antitussive agents for the treatment of coughs.
Brand:CaymanSKU:23936 - 10 mgAvailable on backorder
Benzonatate is a reversible voltage-gated sodium channel blocker.{37382} It blocks Nav1.7 currents in a concentration- and voltage-dependent manner (IC50s = 5.9 and 1.4 μM at holding potentials of -100 and -70 mV, respectively) and inhibits action potential firing in catecholamine A differentiated (CAD) cells. Benzonatate also blocks 80% of Nav1.3 currents in N1E-115 cells when used at a concentration of 100 μM. In vivo, benzonatate (0.85 mg/min) reduces the frequency, but has no effect on the amplitude, of the cough reflex in anesthetized dogs.{37383} Formulations containing benzonatate have been used as antitussive agents for the treatment of coughs.
Brand:CaymanSKU:23936 - 5 mgAvailable on backorder
Benzoylaconine is an aconitine-type diterpenoid alkaloid that has been found in Aconitum species.{42485,42486} Benzoylaconine increases protein levels of the efflux transporters P-glycoprotein, multidrug resistance-associated protein 2 (MRP2), and breast cancer resistance protein (BCRP) in LS174T cells in a concentration-dependent manner.{42486,42487} It also increases the protein levels of P-glycoprotein in Caco-2 cells and the pregnane X receptor (PXR) in both Caco-2 and LS174T cells when used at a concentration of 50 μM.{42487} Benzoylaconine (50 μM) reduces the cytotoxic effects of the P-glycoprotein substrates vincristine (Item No. 11764) and doxorubicin (Item No. 15007) in Caco-2 cells. In vivo, benzoylaconine (0.6 mg/kg) increases protein levels of Nrf2, MRP2, and BCRP in the jejunum, ileum, and colon in mice.{42486} It also increases survival of mice injected with a lethal dose of the neurotoxin aconitine (ED50 = 15 mg/kg, i.p.).{42485}
Brand:CaymanSKU:25687 - 1 mgAvailable on backorder
Benzoylaconine is an aconitine-type diterpenoid alkaloid that has been found in Aconitum species.{42485,42486} Benzoylaconine increases protein levels of the efflux transporters P-glycoprotein, multidrug resistance-associated protein 2 (MRP2), and breast cancer resistance protein (BCRP) in LS174T cells in a concentration-dependent manner.{42486,42487} It also increases the protein levels of P-glycoprotein in Caco-2 cells and the pregnane X receptor (PXR) in both Caco-2 and LS174T cells when used at a concentration of 50 μM.{42487} Benzoylaconine (50 μM) reduces the cytotoxic effects of the P-glycoprotein substrates vincristine (Item No. 11764) and doxorubicin (Item No. 15007) in Caco-2 cells. In vivo, benzoylaconine (0.6 mg/kg) increases protein levels of Nrf2, MRP2, and BCRP in the jejunum, ileum, and colon in mice.{42486} It also increases survival of mice injected with a lethal dose of the neurotoxin aconitine (ED50 = 15 mg/kg, i.p.).{42485}
Brand:CaymanSKU:25687 - 10 mgAvailable on backorder
Benzoylaconine is an aconitine-type diterpenoid alkaloid that has been found in Aconitum species.{42485,42486} Benzoylaconine increases protein levels of the efflux transporters P-glycoprotein, multidrug resistance-associated protein 2 (MRP2), and breast cancer resistance protein (BCRP) in LS174T cells in a concentration-dependent manner.{42486,42487} It also increases the protein levels of P-glycoprotein in Caco-2 cells and the pregnane X receptor (PXR) in both Caco-2 and LS174T cells when used at a concentration of 50 μM.{42487} Benzoylaconine (50 μM) reduces the cytotoxic effects of the P-glycoprotein substrates vincristine (Item No. 11764) and doxorubicin (Item No. 15007) in Caco-2 cells. In vivo, benzoylaconine (0.6 mg/kg) increases protein levels of Nrf2, MRP2, and BCRP in the jejunum, ileum, and colon in mice.{42486} It also increases survival of mice injected with a lethal dose of the neurotoxin aconitine (ED50 = 15 mg/kg, i.p.).{42485}
Brand:CaymanSKU:25687 - 25 mgAvailable on backorder
Benzoylaconine is an aconitine-type diterpenoid alkaloid that has been found in Aconitum species.{42485,42486} Benzoylaconine increases protein levels of the efflux transporters P-glycoprotein, multidrug resistance-associated protein 2 (MRP2), and breast cancer resistance protein (BCRP) in LS174T cells in a concentration-dependent manner.{42486,42487} It also increases the protein levels of P-glycoprotein in Caco-2 cells and the pregnane X receptor (PXR) in both Caco-2 and LS174T cells when used at a concentration of 50 μM.{42487} Benzoylaconine (50 μM) reduces the cytotoxic effects of the P-glycoprotein substrates vincristine (Item No. 11764) and doxorubicin (Item No. 15007) in Caco-2 cells. In vivo, benzoylaconine (0.6 mg/kg) increases protein levels of Nrf2, MRP2, and BCRP in the jejunum, ileum, and colon in mice.{42486} It also increases survival of mice injected with a lethal dose of the neurotoxin aconitine (ED50 = 15 mg/kg, i.p.).{42485}
Brand:CaymanSKU:25687 - 5 mgAvailable on backorder
Benzoylpiperazine (Item No. 24016) is an analytical reference standard categorized as a piperazine. This product is intended for research and forensic applications.
Brand:CaymanSKU:24016 - 1 mgAvailable on backorder
Benzoylpiperazine (Item No. 24016) is an analytical reference standard categorized as a piperazine. This product is intended for research and forensic applications.
Brand:CaymanSKU:24016 - 5 mgAvailable on backorder
Benzoylpiperazine (Item No. 24016) is an analytical reference standard categorized as a piperazine. This product is intended for research and forensic applications.
Brand:CaymanSKU:24016 - 50 mgAvailable on backorder
Benztropine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 0.59 nM in rat brain membranes).{26585} It is selective for M1 receptors over the serotonin transporter (Ki = 5,150 nM), however, it also binds to the dopamine transporter and inhibits dopamine reuptake (Kis = 237 and 130 nM, respectively).{26585,20213,26584} Benztropine also inhibits acid sphingomyelinase by 87% when used at a concentration of 10 mM.{26583} Formulations containing benztropine have been used in the management of Parkinson’s disease symptoms such as involuntary tremor and dystonia.
Brand:CaymanSKU:- Benztropine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 0.59 nM in rat brain membranes).{26585} It is selective for M1 receptors over the serotonin transporter (Ki = 5,150 nM), however, it also binds to the dopamine transporter and inhibits dopamine reuptake (Kis = 237 and 130 nM, respectively).{26585,20213,26584} Benztropine also inhibits acid sphingomyelinase by 87% when used at a concentration of 10 mM.{26583} Formulations containing benztropine have been used in the management of Parkinson’s disease symptoms such as involuntary tremor and dystonia.
Brand:CaymanSKU:- Benztropine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 0.59 nM in rat brain membranes).{26585} It is selective for M1 receptors over the serotonin transporter (Ki = 5,150 nM), however, it also binds to the dopamine transporter and inhibits dopamine reuptake (Kis = 237 and 130 nM, respectively).{26585,20213,26584} Benztropine also inhibits acid sphingomyelinase by 87% when used at a concentration of 10 mM.{26583} Formulations containing benztropine have been used in the management of Parkinson’s disease symptoms such as involuntary tremor and dystonia.
Brand:CaymanSKU:- Benztropine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 0.59 nM in rat brain membranes).{26585} It is selective for M1 receptors over the serotonin transporter (Ki = 5,150 nM), however, it also binds to the dopamine transporter and inhibits dopamine reuptake (Kis = 237 and 130 nM, respectively).{26585,20213,26584} Benztropine also inhibits acid sphingomyelinase by 87% when used at a concentration of 10 mM.{26583} Formulations containing benztropine have been used in the management of Parkinson’s disease symptoms such as involuntary tremor and dystonia.
Brand:CaymanSKU:-
Benzydamine is an analytical reference standard categorized as an analgesic.{25012} Benzydamine has been abused and is associated with hallucinations, muscle weakness, and excitability.{25013} This product is intended for research and forensic applications.
Brand:CaymanSKU:- Benzydamine is an analytical reference standard categorized as an analgesic.{25012} Benzydamine has been abused and is associated with hallucinations, muscle weakness, and excitability.{25013} This product is intended for research and forensic applications.
Brand:CaymanSKU:- Benzydamine is an analytical reference standard categorized as an analgesic.{25012} Benzydamine has been abused and is associated with hallucinations, muscle weakness, and excitability.{25013} This product is intended for research and forensic applications.
Brand:CaymanSKU:-
Benzyl-2-acetamido-2-deoxy-α-D-galactopyranoside (benzyl-α-GalNAc) is an inhibitor of mucin synthesis.{54644,54645,54646} It inhibits glucosamine labeling, a marker of mucin synthesis, in Caco-2, HT-29, and T84 colon cancer cells when used at a concentration of 2 mM.{54644} Benzyl-α-GalNAc (0.4, 0.6, and 0.8 mg/ml) enhances cell death induced by 5-fluorouracil (Item No. 14416) in Capan-1 and HPAF-II cells.{54645} LS 174T colon cancer cells grown in the presence of benzyl-α-GalNAc exhibit reduced liver metastasis in a mouse xenograft model compared with control LS 174T cells.{54646}
Brand:CaymanSKU:31747 - 100 mgAvailable on backorder
Benzyl-2-acetamido-2-deoxy-α-D-galactopyranoside (benzyl-α-GalNAc) is an inhibitor of mucin synthesis.{54644,54645,54646} It inhibits glucosamine labeling, a marker of mucin synthesis, in Caco-2, HT-29, and T84 colon cancer cells when used at a concentration of 2 mM.{54644} Benzyl-α-GalNAc (0.4, 0.6, and 0.8 mg/ml) enhances cell death induced by 5-fluorouracil (Item No. 14416) in Capan-1 and HPAF-II cells.{54645} LS 174T colon cancer cells grown in the presence of benzyl-α-GalNAc exhibit reduced liver metastasis in a mouse xenograft model compared with control LS 174T cells.{54646}
Brand:CaymanSKU:31747 - 25 mgAvailable on backorder
Benzyl-2-acetamido-2-deoxy-α-D-galactopyranoside (benzyl-α-GalNAc) is an inhibitor of mucin synthesis.{54644,54645,54646} It inhibits glucosamine labeling, a marker of mucin synthesis, in Caco-2, HT-29, and T84 colon cancer cells when used at a concentration of 2 mM.{54644} Benzyl-α-GalNAc (0.4, 0.6, and 0.8 mg/ml) enhances cell death induced by 5-fluorouracil (Item No. 14416) in Capan-1 and HPAF-II cells.{54645} LS 174T colon cancer cells grown in the presence of benzyl-α-GalNAc exhibit reduced liver metastasis in a mouse xenograft model compared with control LS 174T cells.{54646}
Brand:CaymanSKU:31747 - 250 mgAvailable on backorder
Benzyl-2-acetamido-2-deoxy-α-D-galactopyranoside (benzyl-α-GalNAc) is an inhibitor of mucin synthesis.{54644,54645,54646} It inhibits glucosamine labeling, a marker of mucin synthesis, in Caco-2, HT-29, and T84 colon cancer cells when used at a concentration of 2 mM.{54644} Benzyl-α-GalNAc (0.4, 0.6, and 0.8 mg/ml) enhances cell death induced by 5-fluorouracil (Item No. 14416) in Capan-1 and HPAF-II cells.{54645} LS 174T colon cancer cells grown in the presence of benzyl-α-GalNAc exhibit reduced liver metastasis in a mouse xenograft model compared with control LS 174T cells.{54646}
Brand:CaymanSKU:31747 - 50 mgAvailable on backorder
Bepotastine is an antagonist of the histamine H1 receptor that is selective over H3, α1-, α2-, and β-adrenergic, dopamine D2long, serotonin 5-HT2, muscarinic acetylcholine, and benzodiazepine receptors.{40405} It reduces dye leakage from the nasal passages of rats acutely sensitized to an antigen (ED50 = 0.03 mg/kg) and inhibits histamine-induced bronchoconstriction in the anesthetized dog (ED50 = 3.2 µg/kg).{40408,40407} Bepotastine prevents conjunctival vascular hyperpermeability in a guinea pig model of conjunctivitis in a dose-dependent manner.{40406} Formulations containing bepotastine have been used in the treatment of itching associated with allergic conjunctivitis.
Brand:CaymanSKU:23721 - 10 mgAvailable on backorder
Bepotastine is an antagonist of the histamine H1 receptor that is selective over H3, α1-, α2-, and β-adrenergic, dopamine D2long, serotonin 5-HT2, muscarinic acetylcholine, and benzodiazepine receptors.{40405} It reduces dye leakage from the nasal passages of rats acutely sensitized to an antigen (ED50 = 0.03 mg/kg) and inhibits histamine-induced bronchoconstriction in the anesthetized dog (ED50 = 3.2 µg/kg).{40408,40407} Bepotastine prevents conjunctival vascular hyperpermeability in a guinea pig model of conjunctivitis in a dose-dependent manner.{40406} Formulations containing bepotastine have been used in the treatment of itching associated with allergic conjunctivitis.
Brand:CaymanSKU:23721 - 25 mgAvailable on backorder
Bepotastine is an antagonist of the histamine H1 receptor that is selective over H3, α1-, α2-, and β-adrenergic, dopamine D2long, serotonin 5-HT2, muscarinic acetylcholine, and benzodiazepine receptors.{40405} It reduces dye leakage from the nasal passages of rats acutely sensitized to an antigen (ED50 = 0.03 mg/kg) and inhibits histamine-induced bronchoconstriction in the anesthetized dog (ED50 = 3.2 µg/kg).{40408,40407} Bepotastine prevents conjunctival vascular hyperpermeability in a guinea pig model of conjunctivitis in a dose-dependent manner.{40406} Formulations containing bepotastine have been used in the treatment of itching associated with allergic conjunctivitis.
Brand:CaymanSKU:23721 - 5 mgAvailable on backorder
Bepridil is a dihydropyridine that has anti-anginal and anti-arrhythmic actions by blocking calcium channels in heart and smooth muscle.{22485,28732} It is recognized as a non-selective channel blocker, altering myocardial Ca2+, Na+, and K+ currents.{31412} For example, it blocks voltage-gated Ca2+ (Cav3.2) and K+ (hERG and KCNQ4) channels, sarcoplasmic ATP-sensitive K+ (KATP) channels, and Na+-activated (KNa) channels (IC50s = 7.1, 22, 9.4, 10, and 2.2 µM, respectively).{24593,31415,31413,28732} It also activates mitochondrial ATP-sensitive KATP channels (ED50 = 27.5 µM).{31414}
Brand:CaymanSKU:19645 -Available on backorder
Bepridil is a dihydropyridine that has anti-anginal and anti-arrhythmic actions by blocking calcium channels in heart and smooth muscle.{22485,28732} It is recognized as a non-selective channel blocker, altering myocardial Ca2+, Na+, and K+ currents.{31412} For example, it blocks voltage-gated Ca2+ (Cav3.2) and K+ (hERG and KCNQ4) channels, sarcoplasmic ATP-sensitive K+ (KATP) channels, and Na+-activated (KNa) channels (IC50s = 7.1, 22, 9.4, 10, and 2.2 µM, respectively).{24593,31415,31413,28732} It also activates mitochondrial ATP-sensitive KATP channels (ED50 = 27.5 µM).{31414}
Brand:CaymanSKU:19645 -Available on backorder
Bepridil is a dihydropyridine that has anti-anginal and anti-arrhythmic actions by blocking calcium channels in heart and smooth muscle.{22485,28732} It is recognized as a non-selective channel blocker, altering myocardial Ca2+, Na+, and K+ currents.{31412} For example, it blocks voltage-gated Ca2+ (Cav3.2) and K+ (hERG and KCNQ4) channels, sarcoplasmic ATP-sensitive K+ (KATP) channels, and Na+-activated (KNa) channels (IC50s = 7.1, 22, 9.4, 10, and 2.2 µM, respectively).{24593,31415,31413,28732} It also activates mitochondrial ATP-sensitive KATP channels (ED50 = 27.5 µM).{31414}
Brand:CaymanSKU:19645 -Available on backorder
Bepridil is a dihydropyridine that has anti-anginal and anti-arrhythmic actions by blocking calcium channels in heart and smooth muscle.{22485,28732} It is recognized as a non-selective channel blocker, altering myocardial Ca2+, Na+, and K+ currents.{31412} For example, it blocks voltage-gated Ca2+ (Cav3.2) and K+ (hERG and KCNQ4) channels, sarcoplasmic ATP-sensitive K+ (KATP) channels, and Na+-activated (KNa) channels (IC50s = 7.1, 22, 9.4, 10, and 2.2 µM, respectively).{24593,31415,31413,28732} It also activates mitochondrial ATP-sensitive KATP channels (ED50 = 27.5 µM).{31414}
Brand:CaymanSKU:19645 -Available on backorder
Beraprost is an analog of prostacyclin in which the unstable enol-ether has been replaced by a benzofuran ether function. This modification increases the plasma half-life from 30 seconds to several hours, and permits the compound to be taken orally. Doses of 20-100 µg in humans, given 1 to 3 times per day, have been demonstrated to improve clinical end points in diseases responsive to prostacyclin. Oral beraprost therapy improved the survival and pulmonary hemodynamics of patients with primary pulmonary hypertension.{8136} Beraprost inhibits platelet aggregation in healthy subjects and in diabetic patients at similar doses.{8137,8139}
Brand:CaymanSKU:-Available on backorder
Beraprost is an analog of prostacyclin in which the unstable enol-ether has been replaced by a benzofuran ether function. This modification increases the plasma half-life from 30 seconds to several hours, and permits the compound to be taken orally. Doses of 20-100 µg in humans, given 1 to 3 times per day, have been demonstrated to improve clinical end points in diseases responsive to prostacyclin. Oral beraprost therapy improved the survival and pulmonary hemodynamics of patients with primary pulmonary hypertension.{8136} Beraprost inhibits platelet aggregation in healthy subjects and in diabetic patients at similar doses.{8137,8139}
Brand:CaymanSKU:-Available on backorder
Beraprost is an analog of prostacyclin in which the unstable enol-ether has been replaced by a benzofuran ether function. This modification increases the plasma half-life from 30 seconds to several hours, and permits the compound to be taken orally. Doses of 20-100 µg in humans, given 1 to 3 times per day, have been demonstrated to improve clinical end points in diseases responsive to prostacyclin. Oral beraprost therapy improved the survival and pulmonary hemodynamics of patients with primary pulmonary hypertension.{8136} Beraprost inhibits platelet aggregation in healthy subjects and in diabetic patients at similar doses.{8137,8139}
Brand:CaymanSKU:-Available on backorder
Berberine is a widely distributed berberidaceaen alkaloid found in Berberis, H. canadensis, X. simplicissima, P. amurense, C. chinensis, T. cordifolia, A. mexicana, and E. californica that has been employed in traditional medicine as an antiprotozoal and antidiarrheal agent. Berberine reduces total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides in both humans (at 1 g/day) and hamsters fed 50 mg/kg/day along with a high fat diet.{12390} Berberine does not act through 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibition, but instead enhances LDL-receptor protein and mRNA levels in hepatocytes. Berberine is therefore a natural product that may help control serum cholesterol without the side effects typical of the statin family of hypocholesterolemic drugs.
Brand:CaymanSKU:10006427 - 1 gAvailable on backorder
Berberine is a widely distributed berberidaceaen alkaloid found in Berberis, H. canadensis, X. simplicissima, P. amurense, C. chinensis, T. cordifolia, A. mexicana, and E. californica that has been employed in traditional medicine as an antiprotozoal and antidiarrheal agent. Berberine reduces total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides in both humans (at 1 g/day) and hamsters fed 50 mg/kg/day along with a high fat diet.{12390} Berberine does not act through 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibition, but instead enhances LDL-receptor protein and mRNA levels in hepatocytes. Berberine is therefore a natural product that may help control serum cholesterol without the side effects typical of the statin family of hypocholesterolemic drugs.
Brand:CaymanSKU:10006427 - 10 gAvailable on backorder
Berberine is a widely distributed berberidaceaen alkaloid found in Berberis, H. canadensis, X. simplicissima, P. amurense, C. chinensis, T. cordifolia, A. mexicana, and E. californica that has been employed in traditional medicine as an antiprotozoal and antidiarrheal agent. Berberine reduces total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides in both humans (at 1 g/day) and hamsters fed 50 mg/kg/day along with a high fat diet.{12390} Berberine does not act through 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibition, but instead enhances LDL-receptor protein and mRNA levels in hepatocytes. Berberine is therefore a natural product that may help control serum cholesterol without the side effects typical of the statin family of hypocholesterolemic drugs.
Brand:CaymanSKU:10006427 - 5 gAvailable on backorder
Berberine is a widely distributed berberidaceaen alkaloid found in Berberis, H. canadensis, X. simplicissima, P. amurense, C. chinensis, T. cordifolia, A. mexicana, and E. californica that has been employed in traditional medicine as an antiprotozoal and antidiarrheal agent. Berberine reduces total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides in both humans (at 1 g/day) and hamsters fed 50 mg/kg/day along with a high fat diet.{12390} Berberine does not act through 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibition, but instead enhances LDL-receptor protein and mRNA levels in hepatocytes. Berberine is therefore a natural product that may help control serum cholesterol without the side effects typical of the statin family of hypocholesterolemic drugs.
Brand:CaymanSKU:10006427 - 50 gAvailable on backorder
Bergamottin is a furanocoumarin found in grapefruit juice and lemon, lime, and bergamot oils that has diverse biological activities.{41018} In vitro, bergamottin inhibits migration and invasion of HT-1080 fibrosarcoma cells at sub-cytotoxic concentrations via inhibition of matrix metalloproteinase-9 (MMP-9) expression.{41019} It shows antiproliferative activity against HepG2 liver, HL-60 leukemia, and BGC-823 gastric cancer cell lines in a dose-dependent manner and induces cell death of CHO cells following near ultraviolet irradiation.{41018,41020} Bergamottin inhibits the cytochrome P450 isoform 3A4 (CYP3A4; Ki = 7.7 μM) and is a mixed inhibitor of simvastatin (Item No. 10010344) drug metabolism (Ki = 174 μM).{41021,41022} It also increases glucose consumption in HepG2 cells in a dose-dependent manner.{41020}
Brand:CaymanSKU:10009439 - 1 mgAvailable on backorder
Bergamottin is a furanocoumarin found in grapefruit juice and lemon, lime, and bergamot oils that has diverse biological activities.{41018} In vitro, bergamottin inhibits migration and invasion of HT-1080 fibrosarcoma cells at sub-cytotoxic concentrations via inhibition of matrix metalloproteinase-9 (MMP-9) expression.{41019} It shows antiproliferative activity against HepG2 liver, HL-60 leukemia, and BGC-823 gastric cancer cell lines in a dose-dependent manner and induces cell death of CHO cells following near ultraviolet irradiation.{41018,41020} Bergamottin inhibits the cytochrome P450 isoform 3A4 (CYP3A4; Ki = 7.7 μM) and is a mixed inhibitor of simvastatin (Item No. 10010344) drug metabolism (Ki = 174 μM).{41021,41022} It also increases glucose consumption in HepG2 cells in a dose-dependent manner.{41020}
Brand:CaymanSKU:10009439 - 10 mgAvailable on backorder
Bergamottin is a furanocoumarin found in grapefruit juice and lemon, lime, and bergamot oils that has diverse biological activities.{41018} In vitro, bergamottin inhibits migration and invasion of HT-1080 fibrosarcoma cells at sub-cytotoxic concentrations via inhibition of matrix metalloproteinase-9 (MMP-9) expression.{41019} It shows antiproliferative activity against HepG2 liver, HL-60 leukemia, and BGC-823 gastric cancer cell lines in a dose-dependent manner and induces cell death of CHO cells following near ultraviolet irradiation.{41018,41020} Bergamottin inhibits the cytochrome P450 isoform 3A4 (CYP3A4; Ki = 7.7 μM) and is a mixed inhibitor of simvastatin (Item No. 10010344) drug metabolism (Ki = 174 μM).{41021,41022} It also increases glucose consumption in HepG2 cells in a dose-dependent manner.{41020}
Brand:CaymanSKU:10009439 - 5 mgAvailable on backorder
Bergapten is a furanocoumarin derivative that has been found in grapefruit peel oil and has diverse biological activities.{22311,47434,47435,47436} It decreases the viability of DLD-1 and LoVo colorectal cancer cells in a concentration-dependent manner, halts the cell cycle at the G0/G1 and sub-G1 phases, and induces apoptosis when used at a concentration of 50 μM.{47434} Bergapten has photosensitizing activity and increases the number of sunburn cells in guinea pig skin in response to UVA radiation.{47435} It increases the pain threshold in assays for mechanical, cold, and hot allodynia, as well as mechanical hyperalgesia, in a rat model of vincristine-induced neuropathic pain when administered at a dose of 10 mg/kg. {47436} Bergapten inhibits vincristine-induced increases in plasma TNF-α and IL-1β levels and decreases in glutathione (GSH) levels in the spinal cord and sciatic nerve in rats. It also inhibits the cytochrome P450 (CYP) isoform CYP3A4 with IC50 value of approximately 25 μM in human liver microsomes.{22311}
Brand:CaymanSKU:26254 - 1 gAvailable on backorder
Bergapten is a furanocoumarin derivative that has been found in grapefruit peel oil and has diverse biological activities.{22311,47434,47435,47436} It decreases the viability of DLD-1 and LoVo colorectal cancer cells in a concentration-dependent manner, halts the cell cycle at the G0/G1 and sub-G1 phases, and induces apoptosis when used at a concentration of 50 μM.{47434} Bergapten has photosensitizing activity and increases the number of sunburn cells in guinea pig skin in response to UVA radiation.{47435} It increases the pain threshold in assays for mechanical, cold, and hot allodynia, as well as mechanical hyperalgesia, in a rat model of vincristine-induced neuropathic pain when administered at a dose of 10 mg/kg. {47436} Bergapten inhibits vincristine-induced increases in plasma TNF-α and IL-1β levels and decreases in glutathione (GSH) levels in the spinal cord and sciatic nerve in rats. It also inhibits the cytochrome P450 (CYP) isoform CYP3A4 with IC50 value of approximately 25 μM in human liver microsomes.{22311}
Brand:CaymanSKU:26254 - 10 gAvailable on backorder
Bergapten is a furanocoumarin derivative that has been found in grapefruit peel oil and has diverse biological activities.{22311,47434,47435,47436} It decreases the viability of DLD-1 and LoVo colorectal cancer cells in a concentration-dependent manner, halts the cell cycle at the G0/G1 and sub-G1 phases, and induces apoptosis when used at a concentration of 50 μM.{47434} Bergapten has photosensitizing activity and increases the number of sunburn cells in guinea pig skin in response to UVA radiation.{47435} It increases the pain threshold in assays for mechanical, cold, and hot allodynia, as well as mechanical hyperalgesia, in a rat model of vincristine-induced neuropathic pain when administered at a dose of 10 mg/kg. {47436} Bergapten inhibits vincristine-induced increases in plasma TNF-α and IL-1β levels and decreases in glutathione (GSH) levels in the spinal cord and sciatic nerve in rats. It also inhibits the cytochrome P450 (CYP) isoform CYP3A4 with IC50 value of approximately 25 μM in human liver microsomes.{22311}
Brand:CaymanSKU:26254 - 5 gAvailable on backorder
Bergapten is a furanocoumarin derivative that has been found in grapefruit peel oil and has diverse biological activities.{22311,47434,47435,47436} It decreases the viability of DLD-1 and LoVo colorectal cancer cells in a concentration-dependent manner, halts the cell cycle at the G0/G1 and sub-G1 phases, and induces apoptosis when used at a concentration of 50 μM.{47434} Bergapten has photosensitizing activity and increases the number of sunburn cells in guinea pig skin in response to UVA radiation.{47435} It increases the pain threshold in assays for mechanical, cold, and hot allodynia, as well as mechanical hyperalgesia, in a rat model of vincristine-induced neuropathic pain when administered at a dose of 10 mg/kg. {47436} Bergapten inhibits vincristine-induced increases in plasma TNF-α and IL-1β levels and decreases in glutathione (GSH) levels in the spinal cord and sciatic nerve in rats. It also inhibits the cytochrome P450 (CYP) isoform CYP3A4 with IC50 value of approximately 25 μM in human liver microsomes.{22311}
Brand:CaymanSKU:26254 - 500 mgAvailable on backorder
Bergenin is a glycoside and a major constituent of Peltophorum plants and has diverse biological activities.{43645,43646,43647,43648} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS radicals and inhibits nitrite production in vitro when used at concentrations ranging from 0.1 to 3 mM.{43645} Bergenin induces production of TNF-α, nitric oxide (NO), and IL-12 in M. tuberculosis-infected macrophages.{43646} In vivo, bergenin reduces pulmonary lesion formation and bacterial load in mice infected with M. tuberculosis H37Rv. Bergenin (10 mg/kg, i.p) restores activity of mitochondrial complex I, II, and IV and reduces renal lipid peroxidation, IL-1β production, and shrinkage of glomeruli in a rat model of ethylene glycol-induced renal injury.{43647} It also prevents arrhythmias induced by coronary artery ligation and reperfusion and BaCl2 in mice.{43648}
Brand:CaymanSKU:26406 - 1 gAvailable on backorder
Bergenin is a glycoside and a major constituent of Peltophorum plants and has diverse biological activities.{43645,43646,43647,43648} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS radicals and inhibits nitrite production in vitro when used at concentrations ranging from 0.1 to 3 mM.{43645} Bergenin induces production of TNF-α, nitric oxide (NO), and IL-12 in M. tuberculosis-infected macrophages.{43646} In vivo, bergenin reduces pulmonary lesion formation and bacterial load in mice infected with M. tuberculosis H37Rv. Bergenin (10 mg/kg, i.p) restores activity of mitochondrial complex I, II, and IV and reduces renal lipid peroxidation, IL-1β production, and shrinkage of glomeruli in a rat model of ethylene glycol-induced renal injury.{43647} It also prevents arrhythmias induced by coronary artery ligation and reperfusion and BaCl2 in mice.{43648}
Brand:CaymanSKU:26406 - 250 mgAvailable on backorder
Bergenin is a glycoside and a major constituent of Peltophorum plants and has diverse biological activities.{43645,43646,43647,43648} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS radicals and inhibits nitrite production in vitro when used at concentrations ranging from 0.1 to 3 mM.{43645} Bergenin induces production of TNF-α, nitric oxide (NO), and IL-12 in M. tuberculosis-infected macrophages.{43646} In vivo, bergenin reduces pulmonary lesion formation and bacterial load in mice infected with M. tuberculosis H37Rv. Bergenin (10 mg/kg, i.p) restores activity of mitochondrial complex I, II, and IV and reduces renal lipid peroxidation, IL-1β production, and shrinkage of glomeruli in a rat model of ethylene glycol-induced renal injury.{43647} It also prevents arrhythmias induced by coronary artery ligation and reperfusion and BaCl2 in mice.{43648}
Brand:CaymanSKU:26406 - 5 gAvailable on backorder