Cayman
Showing 11251–11400 of 45550 results
-
Baicalin is a flavonoid that has been found in S. baicalensis and has diverse biological activities.{53853,53854,53855,53857,53856} It reduces myocardial apoptosis and increases cardiac microvessel levels of endothelial nitric oxide synthase (eNOS) in a rat model of ischemia-reperfusion injury when administered at doses of 30 and 100 mg/kg. Baicalin (50 and 80 mg/kg) increases the number of intratumor CD8+ T cells and reduces tumor volume in an H22 murine hepatocellular carcinoma model.{53854} It reduces LPS-induced cortical production of reactive oxygen species (ROS) and levels of IL-1β and TNF-α in a mouse model of neuroinflammation.{53855} Baicalin decreases body weight, increases the number of rats with regular estrous cycles, and ameliorates follicular development in a mouse model of dehydroepiandrosterone-induced polycystic ovary syndrome (PCOS).{53857} It also decreases immobility time in the forced swim test in a mouse model of depression induced by chronic mild stress.{53856}
Brand:CaymanSKU:19843 -Available on backorder
Baicalin is a flavonoid that has been found in S. baicalensis and has diverse biological activities.{53853,53854,53855,53857,53856} It reduces myocardial apoptosis and increases cardiac microvessel levels of endothelial nitric oxide synthase (eNOS) in a rat model of ischemia-reperfusion injury when administered at doses of 30 and 100 mg/kg. Baicalin (50 and 80 mg/kg) increases the number of intratumor CD8+ T cells and reduces tumor volume in an H22 murine hepatocellular carcinoma model.{53854} It reduces LPS-induced cortical production of reactive oxygen species (ROS) and levels of IL-1β and TNF-α in a mouse model of neuroinflammation.{53855} Baicalin decreases body weight, increases the number of rats with regular estrous cycles, and ameliorates follicular development in a mouse model of dehydroepiandrosterone-induced polycystic ovary syndrome (PCOS).{53857} It also decreases immobility time in the forced swim test in a mouse model of depression induced by chronic mild stress.{53856}
Brand:CaymanSKU:19843 -Available on backorder
Baicalin is a flavonoid that has been found in S. baicalensis and has diverse biological activities.{53853,53854,53855,53857,53856} It reduces myocardial apoptosis and increases cardiac microvessel levels of endothelial nitric oxide synthase (eNOS) in a rat model of ischemia-reperfusion injury when administered at doses of 30 and 100 mg/kg. Baicalin (50 and 80 mg/kg) increases the number of intratumor CD8+ T cells and reduces tumor volume in an H22 murine hepatocellular carcinoma model.{53854} It reduces LPS-induced cortical production of reactive oxygen species (ROS) and levels of IL-1β and TNF-α in a mouse model of neuroinflammation.{53855} Baicalin decreases body weight, increases the number of rats with regular estrous cycles, and ameliorates follicular development in a mouse model of dehydroepiandrosterone-induced polycystic ovary syndrome (PCOS).{53857} It also decreases immobility time in the forced swim test in a mouse model of depression induced by chronic mild stress.{53856}
Brand:CaymanSKU:19843 -Available on backorder
Baicalin is a flavonoid that has been found in S. baicalensis and has diverse biological activities.{53853,53854,53855,53857,53856} It reduces myocardial apoptosis and increases cardiac microvessel levels of endothelial nitric oxide synthase (eNOS) in a rat model of ischemia-reperfusion injury when administered at doses of 30 and 100 mg/kg. Baicalin (50 and 80 mg/kg) increases the number of intratumor CD8+ T cells and reduces tumor volume in an H22 murine hepatocellular carcinoma model.{53854} It reduces LPS-induced cortical production of reactive oxygen species (ROS) and levels of IL-1β and TNF-α in a mouse model of neuroinflammation.{53855} Baicalin decreases body weight, increases the number of rats with regular estrous cycles, and ameliorates follicular development in a mouse model of dehydroepiandrosterone-induced polycystic ovary syndrome (PCOS).{53857} It also decreases immobility time in the forced swim test in a mouse model of depression induced by chronic mild stress.{53856}
Brand:CaymanSKU:19843 -Available on backorder
Bakuchiol is a natural meroterpene isolated from P. corylifolia, a plant used in traditional Asian medicine. In addition to having antioxidant and antibacterial actions, bakuchiol has retinol-like effects on gene expression and properties of the skin.{27738,27739,27737} Bakuchiol also inhibits DNA polymerase and UDP-glucuronosyltransferase 2B7 (IC50 = 41 µM).{21166,27736}
Brand:CaymanSKU:11684 - 10 mgAvailable on backorder
Bakuchiol is a natural meroterpene isolated from P. corylifolia, a plant used in traditional Asian medicine. In addition to having antioxidant and antibacterial actions, bakuchiol has retinol-like effects on gene expression and properties of the skin.{27738,27739,27737} Bakuchiol also inhibits DNA polymerase and UDP-glucuronosyltransferase 2B7 (IC50 = 41 µM).{21166,27736}
Brand:CaymanSKU:11684 - 25 mgAvailable on backorder
Bakuchiol is a natural meroterpene isolated from P. corylifolia, a plant used in traditional Asian medicine. In addition to having antioxidant and antibacterial actions, bakuchiol has retinol-like effects on gene expression and properties of the skin.{27738,27739,27737} Bakuchiol also inhibits DNA polymerase and UDP-glucuronosyltransferase 2B7 (IC50 = 41 µM).{21166,27736}
Brand:CaymanSKU:11684 - 5 mgAvailable on backorder
Bakuchiol is a natural meroterpene isolated from P. corylifolia, a plant used in traditional Asian medicine. In addition to having antioxidant and antibacterial actions, bakuchiol has retinol-like effects on gene expression and properties of the skin.{27738,27739,27737} Bakuchiol also inhibits DNA polymerase and UDP-glucuronosyltransferase 2B7 (IC50 = 41 µM).{21166,27736}
Brand:CaymanSKU:11684 - 50 mgAvailable on backorder
Balaglitazone is a partial agonist of peroxisome proliferator-activated receptor γ (PPARγ; EC50 = 1.351 μM in a transactivation assay).{48619} It decreases non-fasting plasma glucose levels in diabetic db/db mice (ED90 = 3 mg/kg per day). Balaglitazone (5 and 10 mg/kg per day) decreases plasma levels of insulin and glucose in an oral glucose tolerance test in diet-induced obese rats.{48620} In doxorubicin-resistant K562 human myelogenous leukemia cells, balaglitazone (25 μM) decreases P-glycoprotein (P-gp) levels, increases intracellular accumulation of the P-gp substrate rhodamine 123 (Item No. 16672), and sensitizes cells to doxorubicin (Item No. 15007).{48621}
Brand:CaymanSKU:28866 - 1 mgAvailable on backorder
Balaglitazone is a partial agonist of peroxisome proliferator-activated receptor γ (PPARγ; EC50 = 1.351 μM in a transactivation assay).{48619} It decreases non-fasting plasma glucose levels in diabetic db/db mice (ED90 = 3 mg/kg per day). Balaglitazone (5 and 10 mg/kg per day) decreases plasma levels of insulin and glucose in an oral glucose tolerance test in diet-induced obese rats.{48620} In doxorubicin-resistant K562 human myelogenous leukemia cells, balaglitazone (25 μM) decreases P-glycoprotein (P-gp) levels, increases intracellular accumulation of the P-gp substrate rhodamine 123 (Item No. 16672), and sensitizes cells to doxorubicin (Item No. 15007).{48621}
Brand:CaymanSKU:28866 - 10 mgAvailable on backorder
Balaglitazone is a partial agonist of peroxisome proliferator-activated receptor γ (PPARγ; EC50 = 1.351 μM in a transactivation assay).{48619} It decreases non-fasting plasma glucose levels in diabetic db/db mice (ED90 = 3 mg/kg per day). Balaglitazone (5 and 10 mg/kg per day) decreases plasma levels of insulin and glucose in an oral glucose tolerance test in diet-induced obese rats.{48620} In doxorubicin-resistant K562 human myelogenous leukemia cells, balaglitazone (25 μM) decreases P-glycoprotein (P-gp) levels, increases intracellular accumulation of the P-gp substrate rhodamine 123 (Item No. 16672), and sensitizes cells to doxorubicin (Item No. 15007).{48621}
Brand:CaymanSKU:28866 - 25 mgAvailable on backorder
Balaglitazone is a partial agonist of peroxisome proliferator-activated receptor γ (PPARγ; EC50 = 1.351 μM in a transactivation assay).{48619} It decreases non-fasting plasma glucose levels in diabetic db/db mice (ED90 = 3 mg/kg per day). Balaglitazone (5 and 10 mg/kg per day) decreases plasma levels of insulin and glucose in an oral glucose tolerance test in diet-induced obese rats.{48620} In doxorubicin-resistant K562 human myelogenous leukemia cells, balaglitazone (25 μM) decreases P-glycoprotein (P-gp) levels, increases intracellular accumulation of the P-gp substrate rhodamine 123 (Item No. 16672), and sensitizes cells to doxorubicin (Item No. 15007).{48621}
Brand:CaymanSKU:28866 - 5 mgAvailable on backorder
Balicatib is a potent inhibitor of cathepsin K (IC50s = 1.4, 56, and 480 nM for human, rat, and mouse forms, respectively).{32548,32549} it is at least 100-fold selective for cathepsin K over cathepsins B, L, and S.{32549} Balicatib has a basic lipophilic nature, resulting in lysosomal trapping and increased selectivity for lysosomal cathepsin K.{32548,32549}
Brand:CaymanSKU:-Available on backorder
Balicatib is a potent inhibitor of cathepsin K (IC50s = 1.4, 56, and 480 nM for human, rat, and mouse forms, respectively).{32548,32549} it is at least 100-fold selective for cathepsin K over cathepsins B, L, and S.{32549} Balicatib has a basic lipophilic nature, resulting in lysosomal trapping and increased selectivity for lysosomal cathepsin K.{32548,32549}
Brand:CaymanSKU:-Available on backorder
Balicatib is a potent inhibitor of cathepsin K (IC50s = 1.4, 56, and 480 nM for human, rat, and mouse forms, respectively).{32548,32549} it is at least 100-fold selective for cathepsin K over cathepsins B, L, and S.{32549} Balicatib has a basic lipophilic nature, resulting in lysosomal trapping and increased selectivity for lysosomal cathepsin K.{32548,32549}
Brand:CaymanSKU:-Available on backorder
Balicatib is a potent inhibitor of cathepsin K (IC50s = 1.4, 56, and 480 nM for human, rat, and mouse forms, respectively).{32548,32549} it is at least 100-fold selective for cathepsin K over cathepsins B, L, and S.{32549} Balicatib has a basic lipophilic nature, resulting in lysosomal trapping and increased selectivity for lysosomal cathepsin K.{32548,32549}
Brand:CaymanSKU:-Available on backorder
Balofloxacin is a fluoroquinolone antibiotic.{36836} It is active against clinical isolates of a variety of Gram-positive and Gram-negative bacteria in vitro, including K. pneumoniae, H. influenzae, N. gonorrhoeae, P. mirabilis, S. pyogenes, and methicillin-resistant S. aureus (MRSA; MIC50s = 0.025-0.78 μg/ml). Balofloxacin inhibits DNA gyrase from E. coli, P. aeruginosa, and S. aureus (IC50s = 0.47, 11, and 2.5 μg/ml, respectively, in a DNA supercoiling assay). It reduces mortality in mouse models of systemic S. aureus, MRSA, S. pneumoniae, K. pneumoniae, and P. aeruginosa infection (ED50s = 5, 20, 10, 160, and 50.4 mg/kg, respectively).{36837}
Brand:CaymanSKU:25504 - 1 gAvailable on backorder
Balofloxacin is a fluoroquinolone antibiotic.{36836} It is active against clinical isolates of a variety of Gram-positive and Gram-negative bacteria in vitro, including K. pneumoniae, H. influenzae, N. gonorrhoeae, P. mirabilis, S. pyogenes, and methicillin-resistant S. aureus (MRSA; MIC50s = 0.025-0.78 μg/ml). Balofloxacin inhibits DNA gyrase from E. coli, P. aeruginosa, and S. aureus (IC50s = 0.47, 11, and 2.5 μg/ml, respectively, in a DNA supercoiling assay). It reduces mortality in mouse models of systemic S. aureus, MRSA, S. pneumoniae, K. pneumoniae, and P. aeruginosa infection (ED50s = 5, 20, 10, 160, and 50.4 mg/kg, respectively).{36837}
Brand:CaymanSKU:25504 - 10 gAvailable on backorder
Balofloxacin is a fluoroquinolone antibiotic.{36836} It is active against clinical isolates of a variety of Gram-positive and Gram-negative bacteria in vitro, including K. pneumoniae, H. influenzae, N. gonorrhoeae, P. mirabilis, S. pyogenes, and methicillin-resistant S. aureus (MRSA; MIC50s = 0.025-0.78 μg/ml). Balofloxacin inhibits DNA gyrase from E. coli, P. aeruginosa, and S. aureus (IC50s = 0.47, 11, and 2.5 μg/ml, respectively, in a DNA supercoiling assay). It reduces mortality in mouse models of systemic S. aureus, MRSA, S. pneumoniae, K. pneumoniae, and P. aeruginosa infection (ED50s = 5, 20, 10, 160, and 50.4 mg/kg, respectively).{36837}
Brand:CaymanSKU:25504 - 5 gAvailable on backorder
Balofloxacin is a fluoroquinolone antibiotic.{36836} It is active against clinical isolates of a variety of Gram-positive and Gram-negative bacteria in vitro, including K. pneumoniae, H. influenzae, N. gonorrhoeae, P. mirabilis, S. pyogenes, and methicillin-resistant S. aureus (MRSA; MIC50s = 0.025-0.78 μg/ml). Balofloxacin inhibits DNA gyrase from E. coli, P. aeruginosa, and S. aureus (IC50s = 0.47, 11, and 2.5 μg/ml, respectively, in a DNA supercoiling assay). It reduces mortality in mouse models of systemic S. aureus, MRSA, S. pneumoniae, K. pneumoniae, and P. aeruginosa infection (ED50s = 5, 20, 10, 160, and 50.4 mg/kg, respectively).{36837}
Brand:CaymanSKU:25504 - 500 mgAvailable on backorder
Balsalazide is a prodrug form of 5-aminosalicylic acid (5-ASA; Item No. 70265).{48536} It is cleaved by bacterial azoreductases in the intestinal lumen to release 5-ASA. Balsalazide (600 mg/kg per day) decreases IL-2 levels and increases IL-6 levels in the serum and colonic mucosa membrane, as well as decreases micro- and macroscopic colonic damage, in a rat model of colitis induced by 2,4-dinitrochlorobenzene (DNCB).{48537} Formulations containing balsalazide have been used in the treatment of ulcerative colitis.
Brand:CaymanSKU:-Available on backorder
Balsalazide is a prodrug form of 5-aminosalicylic acid (5-ASA; Item No. 70265).{48536} It is cleaved by bacterial azoreductases in the intestinal lumen to release 5-ASA. Balsalazide (600 mg/kg per day) decreases IL-2 levels and increases IL-6 levels in the serum and colonic mucosa membrane, as well as decreases micro- and macroscopic colonic damage, in a rat model of colitis induced by 2,4-dinitrochlorobenzene (DNCB).{48537} Formulations containing balsalazide have been used in the treatment of ulcerative colitis.
Brand:CaymanSKU:-Available on backorder
Balsalazide is a prodrug form of 5-aminosalicylic acid (5-ASA; Item No. 70265).{48536} It is cleaved by bacterial azoreductases in the intestinal lumen to release 5-ASA. Balsalazide (600 mg/kg per day) decreases IL-2 levels and increases IL-6 levels in the serum and colonic mucosa membrane, as well as decreases micro- and macroscopic colonic damage, in a rat model of colitis induced by 2,4-dinitrochlorobenzene (DNCB).{48537} Formulations containing balsalazide have been used in the treatment of ulcerative colitis.
Brand:CaymanSKU:-Available on backorder
Balsalazide is a prodrug form of 5-aminosalicylic acid (5-ASA; Item No. 70265).{48536} It is cleaved by bacterial azoreductases in the intestinal lumen to release 5-ASA. Balsalazide (600 mg/kg per day) decreases IL-2 levels and increases IL-6 levels in the serum and colonic mucosa membrane, as well as decreases micro- and macroscopic colonic damage, in a rat model of colitis induced by 2,4-dinitrochlorobenzene (DNCB).{48537} Formulations containing balsalazide have been used in the treatment of ulcerative colitis.
Brand:CaymanSKU:-Available on backorder
Typical mitochondrial uncouplers are lipophilic weak acids that increase proton transport into the mitochondrial matrix through an ATP synthase-independent pathway, thereby uncoupling nutrient oxidation from ATP production. These chemicals are used to determine rate of cellular respiration and have antioxidant effects that protect from ischemia-reperfusion injury. Most proton transporter uncouplers, however, exhibit off-target activity that can lead to undesired effects, including plasma membrane depolarization, mitochondrial inhibition, and cytotoxicity. BAM15 is a mitochondrial protonophore uncoupler that does not depolarize the plasma membrane and protects mice from acute renal ischemic-reperfusion injury.{28818} In comparison to FCCP (Item No. 15218), 1-10 µM BAM15 was shown to increase oxygen flux with equal potency as the classic uncoupler, while displaying a higher maximum rate of mitochondrial respiration and less cytotoxicity.{28818}
Brand:CaymanSKU:-Available on backorder
Typical mitochondrial uncouplers are lipophilic weak acids that increase proton transport into the mitochondrial matrix through an ATP synthase-independent pathway, thereby uncoupling nutrient oxidation from ATP production. These chemicals are used to determine rate of cellular respiration and have antioxidant effects that protect from ischemia-reperfusion injury. Most proton transporter uncouplers, however, exhibit off-target activity that can lead to undesired effects, including plasma membrane depolarization, mitochondrial inhibition, and cytotoxicity. BAM15 is a mitochondrial protonophore uncoupler that does not depolarize the plasma membrane and protects mice from acute renal ischemic-reperfusion injury.{28818} In comparison to FCCP (Item No. 15218), 1-10 µM BAM15 was shown to increase oxygen flux with equal potency as the classic uncoupler, while displaying a higher maximum rate of mitochondrial respiration and less cytotoxicity.{28818}
Brand:CaymanSKU:-Available on backorder
Typical mitochondrial uncouplers are lipophilic weak acids that increase proton transport into the mitochondrial matrix through an ATP synthase-independent pathway, thereby uncoupling nutrient oxidation from ATP production. These chemicals are used to determine rate of cellular respiration and have antioxidant effects that protect from ischemia-reperfusion injury. Most proton transporter uncouplers, however, exhibit off-target activity that can lead to undesired effects, including plasma membrane depolarization, mitochondrial inhibition, and cytotoxicity. BAM15 is a mitochondrial protonophore uncoupler that does not depolarize the plasma membrane and protects mice from acute renal ischemic-reperfusion injury.{28818} In comparison to FCCP (Item No. 15218), 1-10 µM BAM15 was shown to increase oxygen flux with equal potency as the classic uncoupler, while displaying a higher maximum rate of mitochondrial respiration and less cytotoxicity.{28818}
Brand:CaymanSKU:-Available on backorder
Typical mitochondrial uncouplers are lipophilic weak acids that increase proton transport into the mitochondrial matrix through an ATP synthase-independent pathway, thereby uncoupling nutrient oxidation from ATP production. These chemicals are used to determine rate of cellular respiration and have antioxidant effects that protect from ischemia-reperfusion injury. Most proton transporter uncouplers, however, exhibit off-target activity that can lead to undesired effects, including plasma membrane depolarization, mitochondrial inhibition, and cytotoxicity. BAM15 is a mitochondrial protonophore uncoupler that does not depolarize the plasma membrane and protects mice from acute renal ischemic-reperfusion injury.{28818} In comparison to FCCP (Item No. 15218), 1-10 µM BAM15 was shown to increase oxygen flux with equal potency as the classic uncoupler, while displaying a higher maximum rate of mitochondrial respiration and less cytotoxicity.{28818}
Brand:CaymanSKU:-Available on backorder
BAM7 is a direct activator of Bax (EC50 = 3.3 µM) that engages the Bax trigger site and promotes the functional oligomerization of Bax.{32274} It is selective for the BH3 binding site on Bax and does not interact with BH3 binding pockets on other proteins. BAM7 induces Bax-dependent cell death in mouse embryo fibroblasts.{32274}
Brand:CaymanSKU:- BAM7 is a direct activator of Bax (EC50 = 3.3 µM) that engages the Bax trigger site and promotes the functional oligomerization of Bax.{32274} It is selective for the BH3 binding site on Bax and does not interact with BH3 binding pockets on other proteins. BAM7 induces Bax-dependent cell death in mouse embryo fibroblasts.{32274}
Brand:CaymanSKU:- BAM7 is a direct activator of Bax (EC50 = 3.3 µM) that engages the Bax trigger site and promotes the functional oligomerization of Bax.{32274} It is selective for the BH3 binding site on Bax and does not interact with BH3 binding pockets on other proteins. BAM7 induces Bax-dependent cell death in mouse embryo fibroblasts.{32274}
Brand:CaymanSKU:- BAM7 is a direct activator of Bax (EC50 = 3.3 µM) that engages the Bax trigger site and promotes the functional oligomerization of Bax.{32274} It is selective for the BH3 binding site on Bax and does not interact with BH3 binding pockets on other proteins. BAM7 induces Bax-dependent cell death in mouse embryo fibroblasts.{32274}
Brand:CaymanSKU:-
Bambuterol is a prodrug for terbutaline, a long-acting β-adrenoceptor agonist (Ki = 15.4 µM for human β2-adrenergic receptor).{25395} Bambuterol is converted to terbutaline by butyrylcholinesterases in the liver and plasma.{29051} Long-acting β agonists are useful in ameliorating symptoms of asthma.{29052}
Brand:CaymanSKU:-Available on backorder
Bambuterol is a prodrug for terbutaline, a long-acting β-adrenoceptor agonist (Ki = 15.4 µM for human β2-adrenergic receptor).{25395} Bambuterol is converted to terbutaline by butyrylcholinesterases in the liver and plasma.{29051} Long-acting β agonists are useful in ameliorating symptoms of asthma.{29052}
Brand:CaymanSKU:-Available on backorder
Bambuterol is a prodrug for terbutaline, a long-acting β-adrenoceptor agonist (Ki = 15.4 µM for human β2-adrenergic receptor).{25395} Bambuterol is converted to terbutaline by butyrylcholinesterases in the liver and plasma.{29051} Long-acting β agonists are useful in ameliorating symptoms of asthma.{29052}
Brand:CaymanSKU:-Available on backorder
Brand:CaymanSKU:30000 - 1 mgAvailable on backorder
Brand:CaymanSKU:30000 - 5 mgAvailable on backorder
Baohuoside I is a flavonoid that has been isolated from E. koreanum and has diverse biological activities, including enzyme inhibitory, cytoprotective, neuroprotective, antiproliferative, and erectile function properties.{17617,42242,42243,42244,42245} It inhibits human recombinant phosphodiesterase 5A1 (PDE5A1; IC50 = 0.16 μM) in a cell-free assay and protects PC12 rat adrenal cells from hydrogen peroxide-induced death when used at a concentration of 25 μM.{17617,42242} Baohuoside I inhibits the proliferation of HeLa human cervical, MM96E human melanoma, HL-60 human leukemia, and L1210 mouse leukemia cancer cells (IC50s = 7.3, 7.5, 3.6, and 2.8 μg/ml, respectively).{42244} It decreases hippocampal neuronal death and the latency to find the platform in the Morris water maze in a rat model of neurodegeneration induced by streptozotocin (STZ; Item No. 13104) when administered at a dose of 10 mg/kg per day.{42243} Baohuoside I (10 mg/kg per day) also increases intracavernous pressure (ICP) in response to electrical stimulation of the cavernous nerve in an STZ-induced diabetic mouse model of erectile dysfunction.{42245}
Brand:CaymanSKU:25062 - 1 mgAvailable on backorder
Baohuoside I is a flavonoid that has been isolated from E. koreanum and has diverse biological activities, including enzyme inhibitory, cytoprotective, neuroprotective, antiproliferative, and erectile function properties.{17617,42242,42243,42244,42245} It inhibits human recombinant phosphodiesterase 5A1 (PDE5A1; IC50 = 0.16 μM) in a cell-free assay and protects PC12 rat adrenal cells from hydrogen peroxide-induced death when used at a concentration of 25 μM.{17617,42242} Baohuoside I inhibits the proliferation of HeLa human cervical, MM96E human melanoma, HL-60 human leukemia, and L1210 mouse leukemia cancer cells (IC50s = 7.3, 7.5, 3.6, and 2.8 μg/ml, respectively).{42244} It decreases hippocampal neuronal death and the latency to find the platform in the Morris water maze in a rat model of neurodegeneration induced by streptozotocin (STZ; Item No. 13104) when administered at a dose of 10 mg/kg per day.{42243} Baohuoside I (10 mg/kg per day) also increases intracavernous pressure (ICP) in response to electrical stimulation of the cavernous nerve in an STZ-induced diabetic mouse model of erectile dysfunction.{42245}
Brand:CaymanSKU:25062 - 10 mgAvailable on backorder
Baohuoside I is a flavonoid that has been isolated from E. koreanum and has diverse biological activities, including enzyme inhibitory, cytoprotective, neuroprotective, antiproliferative, and erectile function properties.{17617,42242,42243,42244,42245} It inhibits human recombinant phosphodiesterase 5A1 (PDE5A1; IC50 = 0.16 μM) in a cell-free assay and protects PC12 rat adrenal cells from hydrogen peroxide-induced death when used at a concentration of 25 μM.{17617,42242} Baohuoside I inhibits the proliferation of HeLa human cervical, MM96E human melanoma, HL-60 human leukemia, and L1210 mouse leukemia cancer cells (IC50s = 7.3, 7.5, 3.6, and 2.8 μg/ml, respectively).{42244} It decreases hippocampal neuronal death and the latency to find the platform in the Morris water maze in a rat model of neurodegeneration induced by streptozotocin (STZ; Item No. 13104) when administered at a dose of 10 mg/kg per day.{42243} Baohuoside I (10 mg/kg per day) also increases intracavernous pressure (ICP) in response to electrical stimulation of the cavernous nerve in an STZ-induced diabetic mouse model of erectile dysfunction.{42245}
Brand:CaymanSKU:25062 - 25 mgAvailable on backorder
Baohuoside I is a flavonoid that has been isolated from E. koreanum and has diverse biological activities, including enzyme inhibitory, cytoprotective, neuroprotective, antiproliferative, and erectile function properties.{17617,42242,42243,42244,42245} It inhibits human recombinant phosphodiesterase 5A1 (PDE5A1; IC50 = 0.16 μM) in a cell-free assay and protects PC12 rat adrenal cells from hydrogen peroxide-induced death when used at a concentration of 25 μM.{17617,42242} Baohuoside I inhibits the proliferation of HeLa human cervical, MM96E human melanoma, HL-60 human leukemia, and L1210 mouse leukemia cancer cells (IC50s = 7.3, 7.5, 3.6, and 2.8 μg/ml, respectively).{42244} It decreases hippocampal neuronal death and the latency to find the platform in the Morris water maze in a rat model of neurodegeneration induced by streptozotocin (STZ; Item No. 13104) when administered at a dose of 10 mg/kg per day.{42243} Baohuoside I (10 mg/kg per day) also increases intracavernous pressure (ICP) in response to electrical stimulation of the cavernous nerve in an STZ-induced diabetic mouse model of erectile dysfunction.{42245}
Brand:CaymanSKU:25062 - 5 mgAvailable on backorder
BAPTA is a membrane-impermeable calcium chelator that binds extracellular calcium ions.{22804,23059} The presence of four carboxylic acid functional groups allows for the binding of two calcium ions. BAPTA and its derivatives are widely used for the measurement and manipulation of intracellular free calcium concentration.
Brand:CaymanSKU:11706 - 1 gAvailable on backorder
BAPTA is a membrane-impermeable calcium chelator that binds extracellular calcium ions.{22804,23059} The presence of four carboxylic acid functional groups allows for the binding of two calcium ions. BAPTA and its derivatives are widely used for the measurement and manipulation of intracellular free calcium concentration.
Brand:CaymanSKU:11706 - 100 mgAvailable on backorder
BAPTA is a membrane-impermeable calcium chelator that binds extracellular calcium ions.{22804,23059} The presence of four carboxylic acid functional groups allows for the binding of two calcium ions. BAPTA and its derivatives are widely used for the measurement and manipulation of intracellular free calcium concentration.
Brand:CaymanSKU:11706 - 250 mgAvailable on backorder
BAPTA is a membrane-impermeable calcium chelator that binds extracellular calcium ions.{22804,23059} The presence of four carboxylic acid functional groups allows for the binding of two calcium ions. BAPTA and its derivatives are widely used for the measurement and manipulation of intracellular free calcium concentration.
Brand:CaymanSKU:11706 - 500 mgAvailable on backorder
BAPTA (Item No. 11706) is membrane-impermeable calcium chelator that binds extracellular calcium ions (Kd = 0.11 μM), with selectivity over magnesium ions or protons.{22804,23059} BAPTA and its derivatives can also be used as calcium indicators, since the absorption maximum for BAPTA changes when it is complexed with calcium (absorption maxima free/complexed = 254/274 nm, emission maxima free/complexed = 363/363 nm).{25230} BAPTA AM is a cell permeable analog of BAPTA that binds calcium only after the acetoxymethyl group is removed by cytoplasmic esterases.{25228} It is commonly used at 10-100 μM to evaluate the role of intracellular calcium in cell signaling.{25229,25228,25226,25225} It can also be used in animals.{25228} BAPTA AM also inhibits voltage-gated potassium (Kv) channels, including Kv1.3, Kv1.5, and Kv11.1 (Ki = 1.45, 1.23, and 1.30 μM, respectively).{25227}
Brand:CaymanSKU:- BAPTA (Item No. 11706) is membrane-impermeable calcium chelator that binds extracellular calcium ions (Kd = 0.11 μM), with selectivity over magnesium ions or protons.{22804,23059} BAPTA and its derivatives can also be used as calcium indicators, since the absorption maximum for BAPTA changes when it is complexed with calcium (absorption maxima free/complexed = 254/274 nm, emission maxima free/complexed = 363/363 nm).{25230} BAPTA AM is a cell permeable analog of BAPTA that binds calcium only after the acetoxymethyl group is removed by cytoplasmic esterases.{25228} It is commonly used at 10-100 μM to evaluate the role of intracellular calcium in cell signaling.{25229,25228,25226,25225} It can also be used in animals.{25228} BAPTA AM also inhibits voltage-gated potassium (Kv) channels, including Kv1.3, Kv1.5, and Kv11.1 (Ki = 1.45, 1.23, and 1.30 μM, respectively).{25227}
Brand:CaymanSKU:- BAPTA (Item No. 11706) is membrane-impermeable calcium chelator that binds extracellular calcium ions (Kd = 0.11 μM), with selectivity over magnesium ions or protons.{22804,23059} BAPTA and its derivatives can also be used as calcium indicators, since the absorption maximum for BAPTA changes when it is complexed with calcium (absorption maxima free/complexed = 254/274 nm, emission maxima free/complexed = 363/363 nm).{25230} BAPTA AM is a cell permeable analog of BAPTA that binds calcium only after the acetoxymethyl group is removed by cytoplasmic esterases.{25228} It is commonly used at 10-100 μM to evaluate the role of intracellular calcium in cell signaling.{25229,25228,25226,25225} It can also be used in animals.{25228} BAPTA AM also inhibits voltage-gated potassium (Kv) channels, including Kv1.3, Kv1.5, and Kv11.1 (Ki = 1.45, 1.23, and 1.30 μM, respectively).{25227}
Brand:CaymanSKU:- BAPTA (Item No. 11706) is membrane-impermeable calcium chelator that binds extracellular calcium ions (Kd = 0.11 μM), with selectivity over magnesium ions or protons.{22804,23059} BAPTA and its derivatives can also be used as calcium indicators, since the absorption maximum for BAPTA changes when it is complexed with calcium (absorption maxima free/complexed = 254/274 nm, emission maxima free/complexed = 363/363 nm).{25230} BAPTA AM is a cell permeable analog of BAPTA that binds calcium only after the acetoxymethyl group is removed by cytoplasmic esterases.{25228} It is commonly used at 10-100 μM to evaluate the role of intracellular calcium in cell signaling.{25229,25228,25226,25225} It can also be used in animals.{25228} BAPTA AM also inhibits voltage-gated potassium (Kv) channels, including Kv1.3, Kv1.5, and Kv11.1 (Ki = 1.45, 1.23, and 1.30 μM, respectively).{25227}
Brand:CaymanSKU:-
BAR501 is a selective agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1; EC50 = 1 μM) that lacks activity at the farnesoid X receptor (FXR).{36072} In vivo, BAR501 reduces hepatic perfusion pressure and counteracts norepinephrine-induced vasoconstriction in naïve rats. It protects against development of endothelial dysfunction by increasing liver cystathione-γ-liase (CSE) expression and activity, while reducing endothelin 1 (ET-1) gene expression in a rat model of cirrhosis. In vitro, BAR501 increases Akt-dependent phosphorylation of CSE and endothelial nitric oxide synthase (eNOS) and inhibits ET-1 transcription in human liver sinusoidal cells. BAR501 also shifts macrophages from the inflammatory (M1) phenotype to the anti-inflammatory (M2) phenotype and reduces trinitrobenzenesulfonic acid-induced colitis in mice in a dose-dependent manner.{36071}
Brand:CaymanSKU:22460 -Out of stock
BAR501 is a selective agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1; EC50 = 1 μM) that lacks activity at the farnesoid X receptor (FXR).{36072} In vivo, BAR501 reduces hepatic perfusion pressure and counteracts norepinephrine-induced vasoconstriction in naïve rats. It protects against development of endothelial dysfunction by increasing liver cystathione-γ-liase (CSE) expression and activity, while reducing endothelin 1 (ET-1) gene expression in a rat model of cirrhosis. In vitro, BAR501 increases Akt-dependent phosphorylation of CSE and endothelial nitric oxide synthase (eNOS) and inhibits ET-1 transcription in human liver sinusoidal cells. BAR501 also shifts macrophages from the inflammatory (M1) phenotype to the anti-inflammatory (M2) phenotype and reduces trinitrobenzenesulfonic acid-induced colitis in mice in a dose-dependent manner.{36071}
Brand:CaymanSKU:22460 -Out of stock
BAR501 is a selective agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1; EC50 = 1 μM) that lacks activity at the farnesoid X receptor (FXR).{36072} In vivo, BAR501 reduces hepatic perfusion pressure and counteracts norepinephrine-induced vasoconstriction in naïve rats. It protects against development of endothelial dysfunction by increasing liver cystathione-γ-liase (CSE) expression and activity, while reducing endothelin 1 (ET-1) gene expression in a rat model of cirrhosis. In vitro, BAR501 increases Akt-dependent phosphorylation of CSE and endothelial nitric oxide synthase (eNOS) and inhibits ET-1 transcription in human liver sinusoidal cells. BAR501 also shifts macrophages from the inflammatory (M1) phenotype to the anti-inflammatory (M2) phenotype and reduces trinitrobenzenesulfonic acid-induced colitis in mice in a dose-dependent manner.{36071}
Brand:CaymanSKU:22460 -Out of stock
BAR501 is a selective agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1; EC50 = 1 μM) that lacks activity at the farnesoid X receptor (FXR).{36072} In vivo, BAR501 reduces hepatic perfusion pressure and counteracts norepinephrine-induced vasoconstriction in naïve rats. It protects against development of endothelial dysfunction by increasing liver cystathione-γ-liase (CSE) expression and activity, while reducing endothelin 1 (ET-1) gene expression in a rat model of cirrhosis. In vitro, BAR501 increases Akt-dependent phosphorylation of CSE and endothelial nitric oxide synthase (eNOS) and inhibits ET-1 transcription in human liver sinusoidal cells. BAR501 also shifts macrophages from the inflammatory (M1) phenotype to the anti-inflammatory (M2) phenotype and reduces trinitrobenzenesulfonic acid-induced colitis in mice in a dose-dependent manner.{36071}
Brand:CaymanSKU:22460 -Out of stock
BAR501 impurity is an impurity found in the preparation of BAR501 (Item No. 22460) that acts as an agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1). BAR501 impurity (10 µM) induces a 150% increase in luciferase activity in a GP-BAR1 reporter gene assay.{35043}
Brand:CaymanSKU:22461 -Out of stock
BAR501 impurity is an impurity found in the preparation of BAR501 (Item No. 22460) that acts as an agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1). BAR501 impurity (10 µM) induces a 150% increase in luciferase activity in a GP-BAR1 reporter gene assay.{35043}
Brand:CaymanSKU:22461 -Out of stock
BAR501 impurity is an impurity found in the preparation of BAR501 (Item No. 22460) that acts as an agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1). BAR501 impurity (10 µM) induces a 150% increase in luciferase activity in a GP-BAR1 reporter gene assay.{35043}
Brand:CaymanSKU:22461 -Out of stock
BAR502 is a dual agonist of the G protein-coupled bile acid-activated receptor and farnesoid x receptor (GP-BAR1 and FXR; EC50s = 0.2 and 1 μM, respectively).{38107} It increases the expression of the FXR-regulated bile salt export pump (BSEP), organic solute transporter α (OSTα), and small heterodimer partner (SHP) in primary hepatocytes isolated from FXR wild-type mice. BAR502 also increases cAMP-luciferase reporter gene expression, a marker of GP-BAR1 activity, in HEK293T cells.
Brand:CaymanSKU:22462 -Out of stock
BAR502 is a dual agonist of the G protein-coupled bile acid-activated receptor and farnesoid x receptor (GP-BAR1 and FXR; EC50s = 0.2 and 1 μM, respectively).{38107} It increases the expression of the FXR-regulated bile salt export pump (BSEP), organic solute transporter α (OSTα), and small heterodimer partner (SHP) in primary hepatocytes isolated from FXR wild-type mice. BAR502 also increases cAMP-luciferase reporter gene expression, a marker of GP-BAR1 activity, in HEK293T cells.
Brand:CaymanSKU:22462 -Out of stock
BAR502 is a dual agonist of the G protein-coupled bile acid-activated receptor and farnesoid x receptor (GP-BAR1 and FXR; EC50s = 0.2 and 1 μM, respectively).{38107} It increases the expression of the FXR-regulated bile salt export pump (BSEP), organic solute transporter α (OSTα), and small heterodimer partner (SHP) in primary hepatocytes isolated from FXR wild-type mice. BAR502 also increases cAMP-luciferase reporter gene expression, a marker of GP-BAR1 activity, in HEK293T cells.
Brand:CaymanSKU:22462 -Out of stock
BAR502 is a dual agonist of the G protein-coupled bile acid-activated receptor and farnesoid x receptor (GP-BAR1 and FXR; EC50s = 0.2 and 1 μM, respectively).{38107} It increases the expression of the FXR-regulated bile salt export pump (BSEP), organic solute transporter α (OSTα), and small heterodimer partner (SHP) in primary hepatocytes isolated from FXR wild-type mice. BAR502 also increases cAMP-luciferase reporter gene expression, a marker of GP-BAR1 activity, in HEK293T cells.
Brand:CaymanSKU:22462 -Out of stock
Janus kinases (JAKs) are non-receptor kinases that mediate signaling through cytokine receptors, often to members of the signal transducer and activator of transcription (Stat) family.{20362} Baricitinib is an orally bioavailable, reversible inhibitor of JAK1 and JAK2 (IC50s = 5.9 and 5.7 nM, respectively) that has been shown to inhibit cytokine-induced phosphorylation of STAT3 in healthy human volunteers.{27359,27358,27357} It has potential application in various inflammatory disorders, including rheumatoid arthritis.{27359,27357}
Brand:CaymanSKU:-Out of stock
Janus kinases (JAKs) are non-receptor kinases that mediate signaling through cytokine receptors, often to members of the signal transducer and activator of transcription (Stat) family.{20362} Baricitinib is an orally bioavailable, reversible inhibitor of JAK1 and JAK2 (IC50s = 5.9 and 5.7 nM, respectively) that has been shown to inhibit cytokine-induced phosphorylation of STAT3 in healthy human volunteers.{27359,27358,27357} It has potential application in various inflammatory disorders, including rheumatoid arthritis.{27359,27357}
Brand:CaymanSKU:-Out of stock
Janus kinases (JAKs) are non-receptor kinases that mediate signaling through cytokine receptors, often to members of the signal transducer and activator of transcription (Stat) family.{20362} Baricitinib is an orally bioavailable, reversible inhibitor of JAK1 and JAK2 (IC50s = 5.9 and 5.7 nM, respectively) that has been shown to inhibit cytokine-induced phosphorylation of STAT3 in healthy human volunteers.{27359,27358,27357} It has potential application in various inflammatory disorders, including rheumatoid arthritis.{27359,27357}
Brand:CaymanSKU:-Out of stock
Janus kinases (JAKs) are non-receptor kinases that mediate signaling through cytokine receptors, often to members of the signal transducer and activator of transcription (Stat) family.{20362} Baricitinib is an orally bioavailable, reversible inhibitor of JAK1 and JAK2 (IC50s = 5.9 and 5.7 nM, respectively) that has been shown to inhibit cytokine-induced phosphorylation of STAT3 in healthy human volunteers.{27359,27358,27357} It has potential application in various inflammatory disorders, including rheumatoid arthritis.{27359,27357}
Brand:CaymanSKU:-Out of stock
Barnidipine is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery.{34407} It demonstrates antihypertensive activity by reducing peripheral vascular resistance. It decreases blood pressure in spontaneously hypertensive rats when administered orally at 1 and 3 mg/kg per day.{34406} Formulations containing barnidipine have been used as a treatment for hypertension. In obstructive sleep apnea patients with non-dipper pattern hypertension, barnidipine reduced mean nighttime systolic and diastolic arterial blood pressure.{34405}
Brand:CaymanSKU:20448 -Available on backorder
Barnidipine is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery.{34407} It demonstrates antihypertensive activity by reducing peripheral vascular resistance. It decreases blood pressure in spontaneously hypertensive rats when administered orally at 1 and 3 mg/kg per day.{34406} Formulations containing barnidipine have been used as a treatment for hypertension. In obstructive sleep apnea patients with non-dipper pattern hypertension, barnidipine reduced mean nighttime systolic and diastolic arterial blood pressure.{34405}
Brand:CaymanSKU:20448 -Available on backorder
Barnidipine is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery.{34407} It demonstrates antihypertensive activity by reducing peripheral vascular resistance. It decreases blood pressure in spontaneously hypertensive rats when administered orally at 1 and 3 mg/kg per day.{34406} Formulations containing barnidipine have been used as a treatment for hypertension. In obstructive sleep apnea patients with non-dipper pattern hypertension, barnidipine reduced mean nighttime systolic and diastolic arterial blood pressure.{34405}
Brand:CaymanSKU:20448 -Available on backorder
Basmisanil is a negative allosteric modulator/inverse agonist of α5 subunit-containing GABAA receptors.{35164},{35166} Formulations containing basmisanil are in clinical trials for the treatment of cognitive impairments associated with Down syndrome.
Brand:CaymanSKU:21137 -Out of stock
Basmisanil is a negative allosteric modulator/inverse agonist of α5 subunit-containing GABAA receptors.{35164},{35166} Formulations containing basmisanil are in clinical trials for the treatment of cognitive impairments associated with Down syndrome.
Brand:CaymanSKU:21137 -Out of stock
Basmisanil is a negative allosteric modulator/inverse agonist of α5 subunit-containing GABAA receptors.{35164},{35166} Formulations containing basmisanil are in clinical trials for the treatment of cognitive impairments associated with Down syndrome.
Brand:CaymanSKU:21137 -Out of stock
Basmisanil is a negative allosteric modulator/inverse agonist of α5 subunit-containing GABAA receptors.{35164},{35166} Formulations containing basmisanil are in clinical trials for the treatment of cognitive impairments associated with Down syndrome.
Brand:CaymanSKU:21137 -Out of stock
Bassianolide is a cyclodepsipeptide insecticide synthesized by the fungal species B. bassiana and V. lecanii.{34745, 34746} In vivo, the oral administration of bassianolide induces atony in the silkworm B. mori at a concentration of 4 ppm and is lethal at doses exceeding 8 ppm. Atony is similarly induced in silkworm larvae at oral doses as low as 2 µg/larva.{34745} In isolated guinea pig smooth muscle tissue, bassianolide (0.01-1 µM) specifically inhibits the muscarinic, but not nicotinic, receptor-induced contractions in response to acetylcholine.{34747, 34748}
Brand:CaymanSKU:22001 -Out of stock
Bassianolide is a cyclodepsipeptide insecticide synthesized by the fungal species B. bassiana and V. lecanii.{34745, 34746} In vivo, the oral administration of bassianolide induces atony in the silkworm B. mori at a concentration of 4 ppm and is lethal at doses exceeding 8 ppm. Atony is similarly induced in silkworm larvae at oral doses as low as 2 µg/larva.{34745} In isolated guinea pig smooth muscle tissue, bassianolide (0.01-1 µM) specifically inhibits the muscarinic, but not nicotinic, receptor-induced contractions in response to acetylcholine.{34747, 34748}
Brand:CaymanSKU:22001 -Out of stock
Batefenterol is a muscarinic antagonist and β2-adrenergic receptor (β2-AR) agonist (Kis = 1.4, 1.3, and 3.7 nM, for hM2, hM3, and hβ2-AR, respectively in a radioligand binding assay).{40016, 40017} Batefenterol exhibits potent hβ2-AR agonist activity (EC50 = 0.29 nM) with 440- and 320-fold functional selectivity over hβ1- and hβ3-ARs, respectively.{40016} Batefenterol induces smooth muscle relaxation (EC50 = 11 nM) in isolated guinea pig tracheal tissue and inhibits bronchoconstrictor response in a guinea pig bronchoprotection assay (ED50 = 6.4 µg/ml).{40016} Formulations containing batefenterol are in clinical trials to treat chronic obstructive pulmonary disease (COPD).{40018}
Brand:CaymanSKU:21793 -Out of stock
Batefenterol is a muscarinic antagonist and β2-adrenergic receptor (β2-AR) agonist (Kis = 1.4, 1.3, and 3.7 nM, for hM2, hM3, and hβ2-AR, respectively in a radioligand binding assay).{40016, 40017} Batefenterol exhibits potent hβ2-AR agonist activity (EC50 = 0.29 nM) with 440- and 320-fold functional selectivity over hβ1- and hβ3-ARs, respectively.{40016} Batefenterol induces smooth muscle relaxation (EC50 = 11 nM) in isolated guinea pig tracheal tissue and inhibits bronchoconstrictor response in a guinea pig bronchoprotection assay (ED50 = 6.4 µg/ml).{40016} Formulations containing batefenterol are in clinical trials to treat chronic obstructive pulmonary disease (COPD).{40018}
Brand:CaymanSKU:21793 -Out of stock
Batefenterol is a muscarinic antagonist and β2-adrenergic receptor (β2-AR) agonist (Kis = 1.4, 1.3, and 3.7 nM, for hM2, hM3, and hβ2-AR, respectively in a radioligand binding assay).{40016, 40017} Batefenterol exhibits potent hβ2-AR agonist activity (EC50 = 0.29 nM) with 440- and 320-fold functional selectivity over hβ1- and hβ3-ARs, respectively.{40016} Batefenterol induces smooth muscle relaxation (EC50 = 11 nM) in isolated guinea pig tracheal tissue and inhibits bronchoconstrictor response in a guinea pig bronchoprotection assay (ED50 = 6.4 µg/ml).{40016} Formulations containing batefenterol are in clinical trials to treat chronic obstructive pulmonary disease (COPD).{40018}
Brand:CaymanSKU:21793 -Out of stock
Batefenterol is a muscarinic antagonist and β2-adrenergic receptor (β2-AR) agonist (Kis = 1.4, 1.3, and 3.7 nM, for hM2, hM3, and hβ2-AR, respectively in a radioligand binding assay).{40016, 40017} Batefenterol exhibits potent hβ2-AR agonist activity (EC50 = 0.29 nM) with 440- and 320-fold functional selectivity over hβ1- and hβ3-ARs, respectively.{40016} Batefenterol induces smooth muscle relaxation (EC50 = 11 nM) in isolated guinea pig tracheal tissue and inhibits bronchoconstrictor response in a guinea pig bronchoprotection assay (ED50 = 6.4 µg/ml).{40016} Formulations containing batefenterol are in clinical trials to treat chronic obstructive pulmonary disease (COPD).{40018}
Brand:CaymanSKU:21793 -Out of stock
Batimastat is a broad spectrum inhibitor of matrix metalloproteinases (MMP), with IC50 values of 1-5 nM for all MMPs tested, including MMP-1, -2, -3, -7, -9, -13, and -14.{25118,25119,25120,25121} It also potently inhibits TNFα-converting enzyme (IC50 = 14.9 nM).{25119} Because of its action on MMPs, batimastat has anti-proliferative, anti-invasive, and anti-metastatic actions that are relevant, in particular, to cancer.{25117} Batimastat less effectively inhibits the processing of the low affinity IgE receptor CD23 (IC50 = 100 nM).{25122}
Brand:CaymanSKU:- Batimastat is a broad spectrum inhibitor of matrix metalloproteinases (MMP), with IC50 values of 1-5 nM for all MMPs tested, including MMP-1, -2, -3, -7, -9, -13, and -14.{25118,25119,25120,25121} It also potently inhibits TNFα-converting enzyme (IC50 = 14.9 nM).{25119} Because of its action on MMPs, batimastat has anti-proliferative, anti-invasive, and anti-metastatic actions that are relevant, in particular, to cancer.{25117} Batimastat less effectively inhibits the processing of the low affinity IgE receptor CD23 (IC50 = 100 nM).{25122}
Brand:CaymanSKU:- Batimastat is a broad spectrum inhibitor of matrix metalloproteinases (MMP), with IC50 values of 1-5 nM for all MMPs tested, including MMP-1, -2, -3, -7, -9, -13, and -14.{25118,25119,25120,25121} It also potently inhibits TNFα-converting enzyme (IC50 = 14.9 nM).{25119} Because of its action on MMPs, batimastat has anti-proliferative, anti-invasive, and anti-metastatic actions that are relevant, in particular, to cancer.{25117} Batimastat less effectively inhibits the processing of the low affinity IgE receptor CD23 (IC50 = 100 nM).{25122}
Brand:CaymanSKU:-
Bavachin is a flavonoid first isolated from seeds of P. corylifolia. It is a phytoestrogen that activates the estrogen receptors ERα and ERβ (EC50s = 320 and 680 nM, respectively).{31782,31780} Through this action, bavachin stimulates osteoblast proliferation and differentiation and prevents bone loss following ovariectomy in rats.{31779,31781} Bavachin less potently inhibits acyl-coenzyme A:cholesterol acyltransferase (IC50 = 86 µM).{31778}
Brand:CaymanSKU:11685 - 1 mgAvailable on backorder