Cayman
Showing 11101–11250 of 45550 results
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AZD3839 is an inhibitor of beta-secretase 1 (BACE1).{48539,48540} It selectively binds to BACE1 over BACE2 (Kis = 26.1 and 372.4 nM, respectively, for the human enzymes).{48539} It also inhibits human ether-a-go-go-related gene (hERG) potassium channels expressed in CHO cells (IC50 = 4.8 μM).{48540} AZD3839 decreases amyloid-β (Aβ) secretion from mouse Neuro2a neuroblastoma cells and primary neurons (IC50s = 32.2 and 50.9 nM, respectively).{48539} It dose- and time-dependently decreases Aβ levels in the plasma and brain of mice and guinea pigs. AZD3839 also decreases Aβ in the cerebrospinal fluid (CSF) of cynomolgus monkeys when administered at a dose of 20 μmol/kg.
Brand:CaymanSKU:28388 - 10 mgAvailable on backorder
AZD3839 is an inhibitor of beta-secretase 1 (BACE1).{48539,48540} It selectively binds to BACE1 over BACE2 (Kis = 26.1 and 372.4 nM, respectively, for the human enzymes).{48539} It also inhibits human ether-a-go-go-related gene (hERG) potassium channels expressed in CHO cells (IC50 = 4.8 μM).{48540} AZD3839 decreases amyloid-β (Aβ) secretion from mouse Neuro2a neuroblastoma cells and primary neurons (IC50s = 32.2 and 50.9 nM, respectively).{48539} It dose- and time-dependently decreases Aβ levels in the plasma and brain of mice and guinea pigs. AZD3839 also decreases Aβ in the cerebrospinal fluid (CSF) of cynomolgus monkeys when administered at a dose of 20 μmol/kg.
Brand:CaymanSKU:28388 - 25 mgAvailable on backorder
AZD3839 is an inhibitor of beta-secretase 1 (BACE1).{48539,48540} It selectively binds to BACE1 over BACE2 (Kis = 26.1 and 372.4 nM, respectively, for the human enzymes).{48539} It also inhibits human ether-a-go-go-related gene (hERG) potassium channels expressed in CHO cells (IC50 = 4.8 μM).{48540} AZD3839 decreases amyloid-β (Aβ) secretion from mouse Neuro2a neuroblastoma cells and primary neurons (IC50s = 32.2 and 50.9 nM, respectively).{48539} It dose- and time-dependently decreases Aβ levels in the plasma and brain of mice and guinea pigs. AZD3839 also decreases Aβ in the cerebrospinal fluid (CSF) of cynomolgus monkeys when administered at a dose of 20 μmol/kg.
Brand:CaymanSKU:28388 - 5 mgAvailable on backorder
Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3′ hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3.{8039,12235,13740} PI3Kα, β, and δ are class 1A enzymes composed of p110 and p85 subunits, whereas PI3Kγ is a class 1B PI3K composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit.{14518} AZD6482 is a PI3K inhibitor that targets the β isoform more potently than PI3Kδ, PI3Kγ, or PI3Kα (IC50s = 0.69, 13.6, 47.8, and 136 nM, respectively).{29907} It displays 80-fold selectivity for PI3Kβ over PI3k-C2 and DNA-PK and more than 1,000-fold over other PI3K-related kinases.{29907} AZD6482 blocks Akt signaling and tumor growth in a large number of cancer cell lines, including those that are dependent on PI3Kβ activation or PTEN loss.{29907,29910,29908} AZD6482 (20 mg/kg, i.p.) suppresses the growth of PTEN-deficient xenograft tumors in mice.{29907} It also produces an anti-thrombotic effect in dogs without an increase in bleeding time or blood loss.{29909}
Brand:CaymanSKU:- Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3′ hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3.{8039,12235,13740} PI3Kα, β, and δ are class 1A enzymes composed of p110 and p85 subunits, whereas PI3Kγ is a class 1B PI3K composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit.{14518} AZD6482 is a PI3K inhibitor that targets the β isoform more potently than PI3Kδ, PI3Kγ, or PI3Kα (IC50s = 0.69, 13.6, 47.8, and 136 nM, respectively).{29907} It displays 80-fold selectivity for PI3Kβ over PI3k-C2 and DNA-PK and more than 1,000-fold over other PI3K-related kinases.{29907} AZD6482 blocks Akt signaling and tumor growth in a large number of cancer cell lines, including those that are dependent on PI3Kβ activation or PTEN loss.{29907,29910,29908} AZD6482 (20 mg/kg, i.p.) suppresses the growth of PTEN-deficient xenograft tumors in mice.{29907} It also produces an anti-thrombotic effect in dogs without an increase in bleeding time or blood loss.{29909}
Brand:CaymanSKU:- Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3′ hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3.{8039,12235,13740} PI3Kα, β, and δ are class 1A enzymes composed of p110 and p85 subunits, whereas PI3Kγ is a class 1B PI3K composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit.{14518} AZD6482 is a PI3K inhibitor that targets the β isoform more potently than PI3Kδ, PI3Kγ, or PI3Kα (IC50s = 0.69, 13.6, 47.8, and 136 nM, respectively).{29907} It displays 80-fold selectivity for PI3Kβ over PI3k-C2 and DNA-PK and more than 1,000-fold over other PI3K-related kinases.{29907} AZD6482 blocks Akt signaling and tumor growth in a large number of cancer cell lines, including those that are dependent on PI3Kβ activation or PTEN loss.{29907,29910,29908} AZD6482 (20 mg/kg, i.p.) suppresses the growth of PTEN-deficient xenograft tumors in mice.{29907} It also produces an anti-thrombotic effect in dogs without an increase in bleeding time or blood loss.{29909}
Brand:CaymanSKU:- Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3′ hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3.{8039,12235,13740} PI3Kα, β, and δ are class 1A enzymes composed of p110 and p85 subunits, whereas PI3Kγ is a class 1B PI3K composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit.{14518} AZD6482 is a PI3K inhibitor that targets the β isoform more potently than PI3Kδ, PI3Kγ, or PI3Kα (IC50s = 0.69, 13.6, 47.8, and 136 nM, respectively).{29907} It displays 80-fold selectivity for PI3Kβ over PI3k-C2 and DNA-PK and more than 1,000-fold over other PI3K-related kinases.{29907} AZD6482 blocks Akt signaling and tumor growth in a large number of cancer cell lines, including those that are dependent on PI3Kβ activation or PTEN loss.{29907,29910,29908} AZD6482 (20 mg/kg, i.p.) suppresses the growth of PTEN-deficient xenograft tumors in mice.{29907} It also produces an anti-thrombotic effect in dogs without an increase in bleeding time or blood loss.{29909}
Brand:CaymanSKU:-
Azelaic acid is a naturally occurring and saturated dicarboxylic acid with diverse biological activities.{38830,38831,38832,38833,38834} It is a competitive inhibitor of tyrosinase, NADH dehydrogenase, succinic dehydrogenase, and reduced ubiquitinone:cytochrome C oxidoreductase in vitro.{38830,38831} Azelaic acid inhibits the growth and colony formation of B16 murine as well as HMB2 and SK32 human melanoma cells in a concentration-dependent manner but has no effect on CHO cells.{38832} It decreases DNA synthesis, induces mitochondrial damage and dilation of the rough endoplasmic reticulum (RER), and reduces growth of mouse keratinocytes in a dose- and time-dependent manner.{38833} Azelaic acid is bacteriostatic against S. epidermidis, S. aureus, S. capitis, P. acnes, P. avidum, P. mirabilis, and C. albicans in vitro (MICs = 0.03-0.25 M).{38834} Formulations containing azelaic acid have been used in the treatment of acne and hyperpigmentation disorders.
Brand:CaymanSKU:23977 - 100 gAvailable on backorder
Azelaic acid is a naturally occurring and saturated dicarboxylic acid with diverse biological activities.{38830,38831,38832,38833,38834} It is a competitive inhibitor of tyrosinase, NADH dehydrogenase, succinic dehydrogenase, and reduced ubiquitinone:cytochrome C oxidoreductase in vitro.{38830,38831} Azelaic acid inhibits the growth and colony formation of B16 murine as well as HMB2 and SK32 human melanoma cells in a concentration-dependent manner but has no effect on CHO cells.{38832} It decreases DNA synthesis, induces mitochondrial damage and dilation of the rough endoplasmic reticulum (RER), and reduces growth of mouse keratinocytes in a dose- and time-dependent manner.{38833} Azelaic acid is bacteriostatic against S. epidermidis, S. aureus, S. capitis, P. acnes, P. avidum, P. mirabilis, and C. albicans in vitro (MICs = 0.03-0.25 M).{38834} Formulations containing azelaic acid have been used in the treatment of acne and hyperpigmentation disorders.
Brand:CaymanSKU:23977 - 25 gAvailable on backorder
Azelaic acid is a naturally occurring and saturated dicarboxylic acid with diverse biological activities.{38830,38831,38832,38833,38834} It is a competitive inhibitor of tyrosinase, NADH dehydrogenase, succinic dehydrogenase, and reduced ubiquitinone:cytochrome C oxidoreductase in vitro.{38830,38831} Azelaic acid inhibits the growth and colony formation of B16 murine as well as HMB2 and SK32 human melanoma cells in a concentration-dependent manner but has no effect on CHO cells.{38832} It decreases DNA synthesis, induces mitochondrial damage and dilation of the rough endoplasmic reticulum (RER), and reduces growth of mouse keratinocytes in a dose- and time-dependent manner.{38833} Azelaic acid is bacteriostatic against S. epidermidis, S. aureus, S. capitis, P. acnes, P. avidum, P. mirabilis, and C. albicans in vitro (MICs = 0.03-0.25 M).{38834} Formulations containing azelaic acid have been used in the treatment of acne and hyperpigmentation disorders.
Brand:CaymanSKU:23977 - 250 gAvailable on backorder
Azelaic acid is a naturally occurring and saturated dicarboxylic acid with diverse biological activities.{38830,38831,38832,38833,38834} It is a competitive inhibitor of tyrosinase, NADH dehydrogenase, succinic dehydrogenase, and reduced ubiquitinone:cytochrome C oxidoreductase in vitro.{38830,38831} Azelaic acid inhibits the growth and colony formation of B16 murine as well as HMB2 and SK32 human melanoma cells in a concentration-dependent manner but has no effect on CHO cells.{38832} It decreases DNA synthesis, induces mitochondrial damage and dilation of the rough endoplasmic reticulum (RER), and reduces growth of mouse keratinocytes in a dose- and time-dependent manner.{38833} Azelaic acid is bacteriostatic against S. epidermidis, S. aureus, S. capitis, P. acnes, P. avidum, P. mirabilis, and C. albicans in vitro (MICs = 0.03-0.25 M).{38834} Formulations containing azelaic acid have been used in the treatment of acne and hyperpigmentation disorders.
Brand:CaymanSKU:23977 - 50 gAvailable on backorder
Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ.{8499} One of these substances was recently isolated and purified from oxLDL, and identified as azelaoyl PAF.{8953} Azelaoyl PAF is a potent PPARγ agonist which competes for the thiazolidinedione binding site. Azelaoyl PAF is more potent than 15-deoxy-Δ12,14-prostaglandin J2, and equipotent with rosiglitazone as a ligand for this receptor.{8953}
Brand:CaymanSKU:60924 - 1 mgAvailable on backorder
Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ.{8499} One of these substances was recently isolated and purified from oxLDL, and identified as azelaoyl PAF.{8953} Azelaoyl PAF is a potent PPARγ agonist which competes for the thiazolidinedione binding site. Azelaoyl PAF is more potent than 15-deoxy-Δ12,14-prostaglandin J2, and equipotent with rosiglitazone as a ligand for this receptor.{8953}
Brand:CaymanSKU:60924 - 10 mgAvailable on backorder
Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ.{8499} One of these substances was recently isolated and purified from oxLDL, and identified as azelaoyl PAF.{8953} Azelaoyl PAF is a potent PPARγ agonist which competes for the thiazolidinedione binding site. Azelaoyl PAF is more potent than 15-deoxy-Δ12,14-prostaglandin J2, and equipotent with rosiglitazone as a ligand for this receptor.{8953}
Brand:CaymanSKU:60924 - 5 mgAvailable on backorder
Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ.{8499} One of these substances was recently isolated and purified from oxLDL, and identified as azelaoyl PAF.{8953} Azelaoyl PAF is a potent PPARγ agonist which competes for the thiazolidinedione binding site. Azelaoyl PAF is more potent than 15-deoxy-Δ12,14-prostaglandin J2, and equipotent with rosiglitazone as a ligand for this receptor.{8953}
Brand:CaymanSKU:60924 - 500 µgAvailable on backorder
Azelastine is a second generation antihistamine that targets the histamine H1 receptor (Ki = 6.4 nM).{23214,31603} It displays a terminal half-life of 25 hours in man.{31603} Azelastine may be combined with the synthetic glucocorticoid fluticasone in certain formulations for the improvement of symptoms related to allergies.{32981}
Brand:CaymanSKU:20873 -Out of stock
Azelastine is a second generation antihistamine that targets the histamine H1 receptor (Ki = 6.4 nM).{23214,31603} It displays a terminal half-life of 25 hours in man.{31603} Azelastine may be combined with the synthetic glucocorticoid fluticasone in certain formulations for the improvement of symptoms related to allergies.{32981}
Brand:CaymanSKU:20873 -Out of stock
Azelastine is a second generation antihistamine that targets the histamine H1 receptor (Ki = 6.4 nM).{23214,31603} It displays a terminal half-life of 25 hours in man.{31603} Azelastine may be combined with the synthetic glucocorticoid fluticasone in certain formulations for the improvement of symptoms related to allergies.{32981}
Brand:CaymanSKU:20873 -Out of stock
Azeliragon is an orally bioavailable inhibitor of the receptor for advanced glycation endproducts (RAGE; Kd = 12.7 nM for human recombinant sRAGE), which transports amyloid-β (Aβ) from plasma into the CNS.{39734} It is selective for sRAGE over greater than 100 receptors and transporters in a screening assay. Azeliragon (0.3, 1, and 3 mg/kg per day) prevents brain deposition of Aβ (1-40) (Aβ40) and Aβ42 in the APP/SWE/LON transgenic mouse model of Alzheimer’s disease and increases plasma Aβ levels when administered for three months starting at 12 months of age. In the same treatment paradigm, it dose-dependently reduces memory impairments in the Morris water maze compared with untreated control mice, decreasing the latency and distance traveled to the platform. Azeliragon (10 mg/kg) also increases cerebral blood flow in the hippocampus and frontal cortex in tgAPP/SWE/LON mice greater than six months old.
Brand:CaymanSKU:24678 - 10 mgAvailable on backorder
Azeliragon is an orally bioavailable inhibitor of the receptor for advanced glycation endproducts (RAGE; Kd = 12.7 nM for human recombinant sRAGE), which transports amyloid-β (Aβ) from plasma into the CNS.{39734} It is selective for sRAGE over greater than 100 receptors and transporters in a screening assay. Azeliragon (0.3, 1, and 3 mg/kg per day) prevents brain deposition of Aβ (1-40) (Aβ40) and Aβ42 in the APP/SWE/LON transgenic mouse model of Alzheimer’s disease and increases plasma Aβ levels when administered for three months starting at 12 months of age. In the same treatment paradigm, it dose-dependently reduces memory impairments in the Morris water maze compared with untreated control mice, decreasing the latency and distance traveled to the platform. Azeliragon (10 mg/kg) also increases cerebral blood flow in the hippocampus and frontal cortex in tgAPP/SWE/LON mice greater than six months old.
Brand:CaymanSKU:24678 - 25 mgAvailable on backorder
Azeliragon is an orally bioavailable inhibitor of the receptor for advanced glycation endproducts (RAGE; Kd = 12.7 nM for human recombinant sRAGE), which transports amyloid-β (Aβ) from plasma into the CNS.{39734} It is selective for sRAGE over greater than 100 receptors and transporters in a screening assay. Azeliragon (0.3, 1, and 3 mg/kg per day) prevents brain deposition of Aβ (1-40) (Aβ40) and Aβ42 in the APP/SWE/LON transgenic mouse model of Alzheimer’s disease and increases plasma Aβ levels when administered for three months starting at 12 months of age. In the same treatment paradigm, it dose-dependently reduces memory impairments in the Morris water maze compared with untreated control mice, decreasing the latency and distance traveled to the platform. Azeliragon (10 mg/kg) also increases cerebral blood flow in the hippocampus and frontal cortex in tgAPP/SWE/LON mice greater than six months old.
Brand:CaymanSKU:24678 - 5 mgAvailable on backorder
Azelnidipine is a third generation, dihydropyridine L-type calcium channel blocker with a slow onset profile that displays long-lasting antihypertensive activity in hypertensive rat models compared to other L-type calcium channel blockers.{33379,33378}
Brand:CaymanSKU:21249 -Out of stock
Azelnidipine is a third generation, dihydropyridine L-type calcium channel blocker with a slow onset profile that displays long-lasting antihypertensive activity in hypertensive rat models compared to other L-type calcium channel blockers.{33379,33378}
Brand:CaymanSKU:21249 -Out of stock
Azelnidipine is a third generation, dihydropyridine L-type calcium channel blocker with a slow onset profile that displays long-lasting antihypertensive activity in hypertensive rat models compared to other L-type calcium channel blockers.{33379,33378}
Brand:CaymanSKU:21249 -Out of stock
Azidamfenicol is a broad-spectrum chloramphenicol-like antibiotic that is active against Gram-negative and Gram-positive bacteria.{37623} It inhibits ribosomal peptidyltransferase (Ki = 22 µM).{37624}
Brand:CaymanSKU:25449 - 1 mgAvailable on backorder
Azidamfenicol is a broad-spectrum chloramphenicol-like antibiotic that is active against Gram-negative and Gram-positive bacteria.{37623} It inhibits ribosomal peptidyltransferase (Ki = 22 µM).{37624}
Brand:CaymanSKU:25449 - 5 mgAvailable on backorder
Azido-dPEG7-amine is a heterobifunctional PEGylated linker.{52509} It contains a reactive NH2 end group, as well as an azide functional group for use in click chemistry reactions. Azido-dPEG7-amine has been used as a linker in the synthesis of bivalent mammalian target of rapamycin (mTOR) inhibitors.{52510}
Brand:CaymanSKU:30544 - 1 mgAvailable on backorder
Azido-dPEG7-amine is a heterobifunctional PEGylated linker.{52509} It contains a reactive NH2 end group, as well as an azide functional group for use in click chemistry reactions. Azido-dPEG7-amine has been used as a linker in the synthesis of bivalent mammalian target of rapamycin (mTOR) inhibitors.{52510}
Brand:CaymanSKU:30544 - 10 mgAvailable on backorder
Azido-dPEG7-amine is a heterobifunctional PEGylated linker.{52509} It contains a reactive NH2 end group, as well as an azide functional group for use in click chemistry reactions. Azido-dPEG7-amine has been used as a linker in the synthesis of bivalent mammalian target of rapamycin (mTOR) inhibitors.{52510}
Brand:CaymanSKU:30544 - 25 mgAvailable on backorder
Azido-dPEG7-amine is a heterobifunctional PEGylated linker.{52509} It contains a reactive NH2 end group, as well as an azide functional group for use in click chemistry reactions. Azido-dPEG7-amine has been used as a linker in the synthesis of bivalent mammalian target of rapamycin (mTOR) inhibitors.{52510}
Brand:CaymanSKU:30544 - 5 mgAvailable on backorder
FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.{11265} FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5).{11284} Down-regulation of S1P1 receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer’s patch.{11738} azido-FTY720 is a highly photoreactive analog of FTY720 that can be used to identify receptor binding sites for this ligand.{14080}
Brand:CaymanSKU:10008612 - 1 mgAvailable on backorder
FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.{11265} FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5).{11284} Down-regulation of S1P1 receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer’s patch.{11738} azido-FTY720 is a highly photoreactive analog of FTY720 that can be used to identify receptor binding sites for this ligand.{14080}
Brand:CaymanSKU:10008612 - 100 µgAvailable on backorder
FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.{11265} FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5).{11284} Down-regulation of S1P1 receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer’s patch.{11738} azido-FTY720 is a highly photoreactive analog of FTY720 that can be used to identify receptor binding sites for this ligand.{14080}
Brand:CaymanSKU:10008612 - 5 mgAvailable on backorder
FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.{11265} FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5).{11284} Down-regulation of S1P1 receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer’s patch.{11738} azido-FTY720 is a highly photoreactive analog of FTY720 that can be used to identify receptor binding sites for this ligand.{14080}
Brand:CaymanSKU:10008612 - 500 µgAvailable on backorder
Azido-thalidomide is a building block in the synthesis of proteolysis-targeting chimera (PROTAC) technologies.{46112} It contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry. Azido-thalidomide has been used in the synthesis of a SirReal-based PROTAC for the degradation of sirtuin 2 (Sirt2) in cells.
Brand:CaymanSKU:26146 - 10 mgAvailable on backorder
Azido-thalidomide is a building block in the synthesis of proteolysis-targeting chimera (PROTAC) technologies.{46112} It contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry. Azido-thalidomide has been used in the synthesis of a SirReal-based PROTAC for the degradation of sirtuin 2 (Sirt2) in cells.
Brand:CaymanSKU:26146 - 25 mgAvailable on backorder
Azido-thalidomide is a building block in the synthesis of proteolysis-targeting chimera (PROTAC) technologies.{46112} It contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry. Azido-thalidomide has been used in the synthesis of a SirReal-based PROTAC for the degradation of sirtuin 2 (Sirt2) in cells.
Brand:CaymanSKU:26146 - 5 mgAvailable on backorder
Azido-thalidomide is a building block in the synthesis of proteolysis-targeting chimera (PROTAC) technologies.{46112} It contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry. Azido-thalidomide has been used in the synthesis of a SirReal-based PROTAC for the degradation of sirtuin 2 (Sirt2) in cells.
Brand:CaymanSKU:26146 - 50 mgAvailable on backorder
UR-144 (Item No. 11502) and XLR11 (Item No. 11565) are potent synthetic cannabinoids (CBs) that have been identified as adulterants of herbal products.{22648,23290} Azidoindolene 1 is structurally similar to UR-144, XLR11, and a number of additional synthetic CBs with a hydrazide linking the tetramethylcyclopropyl group to the aminoalkylindole group. The physiological and toxicological properties of this compound are not known. Typically, a tetramethylcyclopropyl group confers selectivity for the peripheral CB2 receptor, and the addition of substituents at the N1-amine of the aminoalkylindole group is necessary for high affinity at either CB1 or CB2.{20487} This product is intended for forensic and research applications.
Brand:CaymanSKU:-Out of stock
UR-144 (Item No. 11502) and XLR11 (Item No. 11565) are potent synthetic cannabinoids (CBs) that have been identified as adulterants of herbal products.{22648,23290} Azidoindolene 1 is structurally similar to UR-144, XLR11, and a number of additional synthetic CBs with a hydrazide linking the tetramethylcyclopropyl group to the aminoalkylindole group. The physiological and toxicological properties of this compound are not known. Typically, a tetramethylcyclopropyl group confers selectivity for the peripheral CB2 receptor, and the addition of substituents at the N1-amine of the aminoalkylindole group is necessary for high affinity at either CB1 or CB2.{20487} This product is intended for forensic and research applications.
Brand:CaymanSKU:-Out of stock
UR-144 (Item No. 11502) and XLR11 (Item No. 11565) are potent synthetic cannabinoids (CBs) that have been identified as adulterants of herbal products.{22648,23290} Azidoindolene 1 is structurally similar to UR-144, XLR11, and a number of additional synthetic CBs with a hydrazide linking the tetramethylcyclopropyl group to the aminoalkylindole group. The physiological and toxicological properties of this compound are not known. Typically, a tetramethylcyclopropyl group confers selectivity for the peripheral CB2 receptor, and the addition of substituents at the N1-amine of the aminoalkylindole group is necessary for high affinity at either CB1 or CB2.{20487} This product is intended for forensic and research applications.
Brand:CaymanSKU:-Out of stock
Azilsartan is an inverse agonist of the angiotensin II type 1 receptor (AT1; IC50 = 2.6 nM) and the active metabolite of the prodrug azilsartan medoxomil (Item No. 23805).{46062} It reduces the maximal contractile response induced by angiotensin II in isolated rabbit aortic strips (pD2 = 9.9), an effect that persists following washout, indicating slow dissociation.
Brand:CaymanSKU:26091 - 1 gAvailable on backorder
Azilsartan is an inverse agonist of the angiotensin II type 1 receptor (AT1; IC50 = 2.6 nM) and the active metabolite of the prodrug azilsartan medoxomil (Item No. 23805).{46062} It reduces the maximal contractile response induced by angiotensin II in isolated rabbit aortic strips (pD2 = 9.9), an effect that persists following washout, indicating slow dissociation.
Brand:CaymanSKU:26091 - 100 mgAvailable on backorder
Azilsartan is an inverse agonist of the angiotensin II type 1 receptor (AT1; IC50 = 2.6 nM) and the active metabolite of the prodrug azilsartan medoxomil (Item No. 23805).{46062} It reduces the maximal contractile response induced by angiotensin II in isolated rabbit aortic strips (pD2 = 9.9), an effect that persists following washout, indicating slow dissociation.
Brand:CaymanSKU:26091 - 250 mgAvailable on backorder
Azilsartan is an inverse agonist of the angiotensin II type 1 receptor (AT1; IC50 = 2.6 nM) and the active metabolite of the prodrug azilsartan medoxomil (Item No. 23805).{46062} It reduces the maximal contractile response induced by angiotensin II in isolated rabbit aortic strips (pD2 = 9.9), an effect that persists following washout, indicating slow dissociation.
Brand:CaymanSKU:26091 - 500 mgAvailable on backorder
Azilsartan medoxomil is a prodrug form of azilsartan (Item No. 26091), a potent and selective angiotensin II receptor 1 (AT1) antagonist.{36288,36289} Azilsartan medoxomil (0.1-10 mg/kg) reduces blood pressure and decreases plasminogen activator inhibitor 1 (PAI-1) levels in the plasma, left ventricle, and aortic wall in mice in a dose-dependent manner.{36289} It also inhibits the pressor response induced by angiotensin II (Item No. 17150) in normotensive rats (ID50 = 0.12 mg/kg) and reduces blood pressure and improves glucose infusion, a marker of insulin sensitivity, in spontaneously hypertensive rats.{36290} Azilsartan medoxomil also has more potent antiproteinuric effects in Wistar fatty rats than olmesartan medoxomil (Item No. 11614). Formulations containing azilsartan medoxomil have been used in the treatment of hypertension.
Brand:CaymanSKU:23805 - 1 mgAvailable on backorder
Azilsartan medoxomil is a prodrug form of azilsartan (Item No. 26091), a potent and selective angiotensin II receptor 1 (AT1) antagonist.{36288,36289} Azilsartan medoxomil (0.1-10 mg/kg) reduces blood pressure and decreases plasminogen activator inhibitor 1 (PAI-1) levels in the plasma, left ventricle, and aortic wall in mice in a dose-dependent manner.{36289} It also inhibits the pressor response induced by angiotensin II (Item No. 17150) in normotensive rats (ID50 = 0.12 mg/kg) and reduces blood pressure and improves glucose infusion, a marker of insulin sensitivity, in spontaneously hypertensive rats.{36290} Azilsartan medoxomil also has more potent antiproteinuric effects in Wistar fatty rats than olmesartan medoxomil (Item No. 11614). Formulations containing azilsartan medoxomil have been used in the treatment of hypertension.
Brand:CaymanSKU:23805 - 10 mgAvailable on backorder
Azilsartan medoxomil is a prodrug form of azilsartan (Item No. 26091), a potent and selective angiotensin II receptor 1 (AT1) antagonist.{36288,36289} Azilsartan medoxomil (0.1-10 mg/kg) reduces blood pressure and decreases plasminogen activator inhibitor 1 (PAI-1) levels in the plasma, left ventricle, and aortic wall in mice in a dose-dependent manner.{36289} It also inhibits the pressor response induced by angiotensin II (Item No. 17150) in normotensive rats (ID50 = 0.12 mg/kg) and reduces blood pressure and improves glucose infusion, a marker of insulin sensitivity, in spontaneously hypertensive rats.{36290} Azilsartan medoxomil also has more potent antiproteinuric effects in Wistar fatty rats than olmesartan medoxomil (Item No. 11614). Formulations containing azilsartan medoxomil have been used in the treatment of hypertension.
Brand:CaymanSKU:23805 - 25 mgAvailable on backorder
Azilsartan medoxomil is a prodrug form of azilsartan (Item No. 26091), a potent and selective angiotensin II receptor 1 (AT1) antagonist.{36288,36289} Azilsartan medoxomil (0.1-10 mg/kg) reduces blood pressure and decreases plasminogen activator inhibitor 1 (PAI-1) levels in the plasma, left ventricle, and aortic wall in mice in a dose-dependent manner.{36289} It also inhibits the pressor response induced by angiotensin II (Item No. 17150) in normotensive rats (ID50 = 0.12 mg/kg) and reduces blood pressure and improves glucose infusion, a marker of insulin sensitivity, in spontaneously hypertensive rats.{36290} Azilsartan medoxomil also has more potent antiproteinuric effects in Wistar fatty rats than olmesartan medoxomil (Item No. 11614). Formulations containing azilsartan medoxomil have been used in the treatment of hypertension.
Brand:CaymanSKU:23805 - 5 mgAvailable on backorder
Azimilide is a class III antiarrhythmic agent.{46367} It blocks rapidly activating delayed rectifier (IKr) and slowly activating delayed rectifier (IKs) potassium currents in isolated guinea pig ventricular myocytes (IC50s = 0.3 and 3 μM, respectively). Azimilide (0.1-10 μM) prolongs action potential duration (APD) in isolated calf Purkinje fibers and ventricular trabeculae in a concentration-dependent manner. It increases the effective refractory period (ERP) in isolated perfused guinea pig hearts and ferret papillary muscles. Azimilide (0.3-30 mg/kg) increases ERP and the absolute refractory period and decreases heart rate in dogs. It reduces mean arrhythmia score in a rat model of coronary artery ligation and reperfusion-induced severe ventricular arrhythmia. Azimilide (10-30 mg/kg) also prevents sustained and non-sustained ventricular tachyarrhythmias in dogs.
Brand:CaymanSKU:28300 - 10 mgAvailable on backorder
Azimilide is a class III antiarrhythmic agent.{46367} It blocks rapidly activating delayed rectifier (IKr) and slowly activating delayed rectifier (IKs) potassium currents in isolated guinea pig ventricular myocytes (IC50s = 0.3 and 3 μM, respectively). Azimilide (0.1-10 μM) prolongs action potential duration (APD) in isolated calf Purkinje fibers and ventricular trabeculae in a concentration-dependent manner. It increases the effective refractory period (ERP) in isolated perfused guinea pig hearts and ferret papillary muscles. Azimilide (0.3-30 mg/kg) increases ERP and the absolute refractory period and decreases heart rate in dogs. It reduces mean arrhythmia score in a rat model of coronary artery ligation and reperfusion-induced severe ventricular arrhythmia. Azimilide (10-30 mg/kg) also prevents sustained and non-sustained ventricular tachyarrhythmias in dogs.
Brand:CaymanSKU:28300 - 100 mgAvailable on backorder
Azimilide is a class III antiarrhythmic agent.{46367} It blocks rapidly activating delayed rectifier (IKr) and slowly activating delayed rectifier (IKs) potassium currents in isolated guinea pig ventricular myocytes (IC50s = 0.3 and 3 μM, respectively). Azimilide (0.1-10 μM) prolongs action potential duration (APD) in isolated calf Purkinje fibers and ventricular trabeculae in a concentration-dependent manner. It increases the effective refractory period (ERP) in isolated perfused guinea pig hearts and ferret papillary muscles. Azimilide (0.3-30 mg/kg) increases ERP and the absolute refractory period and decreases heart rate in dogs. It reduces mean arrhythmia score in a rat model of coronary artery ligation and reperfusion-induced severe ventricular arrhythmia. Azimilide (10-30 mg/kg) also prevents sustained and non-sustained ventricular tachyarrhythmias in dogs.
Brand:CaymanSKU:28300 - 50 mgAvailable on backorder
Azithromycin is a macrolide antibiotic.{22758} It is active against S. pneumoniae, S. aureus, N. gonorrhoeae, M. pneumoniae, H. pylori, C. trachomatis, and H. influenzae in vitro (MIC90s = S. pyogenes, S. pneumoniae, E. faecalis, or H. influenzae infection (ED50s = 0.78, 8.7, 12.7, and 30.3 mg/kg, respectively).{53594} It also decreases plasma levels of IL-6, TNF-α, and IL-1β and increases survival in mouse model of LPS-induced sepsis when administered at a dose of 100 mg/kg.{53595} Formulations containing azithromycin have been used in the treatment of a variety of bacterial infections.
Brand:CaymanSKU:- Azithromycin is a macrolide antibiotic.{22758} It is active against S. pneumoniae, S. aureus, N. gonorrhoeae, M. pneumoniae, H. pylori, C. trachomatis, and H. influenzae in vitro (MIC90s = S. pyogenes, S. pneumoniae, E. faecalis, or H. influenzae infection (ED50s = 0.78, 8.7, 12.7, and 30.3 mg/kg, respectively).{53594} It also decreases plasma levels of IL-6, TNF-α, and IL-1β and increases survival in mouse model of LPS-induced sepsis when administered at a dose of 100 mg/kg.{53595} Formulations containing azithromycin have been used in the treatment of a variety of bacterial infections.
Brand:CaymanSKU:- Azithromycin is a macrolide antibiotic.{22758} It is active against S. pneumoniae, S. aureus, N. gonorrhoeae, M. pneumoniae, H. pylori, C. trachomatis, and H. influenzae in vitro (MIC90s = S. pyogenes, S. pneumoniae, E. faecalis, or H. influenzae infection (ED50s = 0.78, 8.7, 12.7, and 30.3 mg/kg, respectively).{53594} It also decreases plasma levels of IL-6, TNF-α, and IL-1β and increases survival in mouse model of LPS-induced sepsis when administered at a dose of 100 mg/kg.{53595} Formulations containing azithromycin have been used in the treatment of a variety of bacterial infections.
Brand:CaymanSKU:- Azithromycin is a macrolide antibiotic.{22758} It is active against S. pneumoniae, S. aureus, N. gonorrhoeae, M. pneumoniae, H. pylori, C. trachomatis, and H. influenzae in vitro (MIC90s = S. pyogenes, S. pneumoniae, E. faecalis, or H. influenzae infection (ED50s = 0.78, 8.7, 12.7, and 30.3 mg/kg, respectively).{53594} It also decreases plasma levels of IL-6, TNF-α, and IL-1β and increases survival in mouse model of LPS-induced sepsis when administered at a dose of 100 mg/kg.{53595} Formulations containing azithromycin have been used in the treatment of a variety of bacterial infections.
Brand:CaymanSKU:-
Azithromycin-d3 is intended for use as an internal standard for the quantification of azithromycin (Item No. 15004) by GC- or LC-MS. Azithromycin is a macrolide antibiotic.{22758} It is active against S. pneumoniae, S. aureus, N. gonorrhoeae, M. pneumoniae, H. pylori, C. trachomatis, and H. influenzae in vitro (MIC90s = S. pyogenes, S. pneumoniae, E. faecalis, or H. influenzae infection (ED50s = 0.78, 8.7, 12.7, and 30.3 mg/kg, respectively).{53594} It also decreases plasma levels of IL-6, TNF-α, and IL-1β and increases survival in mouse model of LPS-induced sepsis when administered at a dose of 100 mg/kg.{53595} Formulations containing azithromycin have been used in the treatment of a variety of bacterial infections.
Brand:CaymanSKU:20675 -Available on backorder
Azlocillin is a semi-synthetic acylureidopenicillin with broad spectrum antibacterial properties.{29939,29941} Like the structurally related antibiotics mezlocillin and piperacillin (Item no. 20766), azlocillin is effective against the Enterobacteriaceae, including strains of K. pneumoniae that are resistant to older penicillins.{29938} Azlocillin is part of antibiotic cocktails known as PANTA (with polymyxin B (Item No. 14157)), amphotericin B (Item No. 11636), nalidixic acid (Item No. 19807), and trimethoprim (Item No. 16473) and PANTAV (PANTA with vancomycin (Item No. 15327)).{20813} Azlocillin is also effective against the malarial parasite P. falciparum at concentrations similar to those used during antibiotic therapy.{29940}
Brand:CaymanSKU:-Available on backorder
Azlocillin is a semi-synthetic acylureidopenicillin with broad spectrum antibacterial properties.{29939,29941} Like the structurally related antibiotics mezlocillin and piperacillin (Item no. 20766), azlocillin is effective against the Enterobacteriaceae, including strains of K. pneumoniae that are resistant to older penicillins.{29938} Azlocillin is part of antibiotic cocktails known as PANTA (with polymyxin B (Item No. 14157)), amphotericin B (Item No. 11636), nalidixic acid (Item No. 19807), and trimethoprim (Item No. 16473) and PANTAV (PANTA with vancomycin (Item No. 15327)).{20813} Azlocillin is also effective against the malarial parasite P. falciparum at concentrations similar to those used during antibiotic therapy.{29940}
Brand:CaymanSKU:-Available on backorder
Azlocillin is a semi-synthetic acylureidopenicillin with broad spectrum antibacterial properties.{29939,29941} Like the structurally related antibiotics mezlocillin and piperacillin (Item no. 20766), azlocillin is effective against the Enterobacteriaceae, including strains of K. pneumoniae that are resistant to older penicillins.{29938} Azlocillin is part of antibiotic cocktails known as PANTA (with polymyxin B (Item No. 14157)), amphotericin B (Item No. 11636), nalidixic acid (Item No. 19807), and trimethoprim (Item No. 16473) and PANTAV (PANTA with vancomycin (Item No. 15327)).{20813} Azlocillin is also effective against the malarial parasite P. falciparum at concentrations similar to those used during antibiotic therapy.{29940}
Brand:CaymanSKU:-Available on backorder
Azomycin is a nitroimidazole antibiotic and radiosensitizer.{42142,52143} It is active against B. subtilis, M. pyogenes, E. coli, S. dysenteriae, S. paradysenteriae, S. typhi, S. paratyphosa, B. anthracis, M. tuberculosis, and M. phlei in vitro.{42142} Azomycin enhances radiation-induced cell death in HT-1080, LoVo, and V79-379A cancer cells.{52143}
Brand:CaymanSKU:29395 - 1 gAvailable on backorder
Azomycin is a nitroimidazole antibiotic and radiosensitizer.{42142,52143} It is active against B. subtilis, M. pyogenes, E. coli, S. dysenteriae, S. paradysenteriae, S. typhi, S. paratyphosa, B. anthracis, M. tuberculosis, and M. phlei in vitro.{42142} Azomycin enhances radiation-induced cell death in HT-1080, LoVo, and V79-379A cancer cells.{52143}
Brand:CaymanSKU:29395 - 5 gAvailable on backorder
Azomycin is a nitroimidazole antibiotic and radiosensitizer.{42142,52143} It is active against B. subtilis, M. pyogenes, E. coli, S. dysenteriae, S. paradysenteriae, S. typhi, S. paratyphosa, B. anthracis, M. tuberculosis, and M. phlei in vitro.{42142} Azomycin enhances radiation-induced cell death in HT-1080, LoVo, and V79-379A cancer cells.{52143}
Brand:CaymanSKU:29395 - 500 mgAvailable on backorder
The unfolded protein response (UPR) maintains balance between protein synthesis and endoplasmic reticulum (ER) protein-folding by inhibiting translation to decrease global protein synthesis, increasing degradation and disposal of unfolded protein intermediates from the ER, and increasing the folding capacity of the ER by expanding its volume and increasing chaperone synthesis. Chronic ER stress leads to a defective UPR and is strongly associated with neurodegenerative diseases, cancers, and metabolic syndrome. Azoramide is a small molecule that has been shown to improve ER protein-folding ability by dose-dependently (1-25 µM) activating reporter genes whose expression is driven by the cellular UPR response element and the ER stress response element.{29136} At 1-25 µM, this compound can also stimulate the expression of multiple chaperone proteins to enhance ER chaperone capacity and induce phosphorylation of eukaryotic translation initiation factor 2α subunit (eIF2α) to reduce protein synthesis.{29136} At 150 mg/kg, azoramide exerts antidiabetic activity in both ob/ob and diet-induced obese mice, improving insulin sensitivity and glucose homeostasis, as well as protecting pancreatic β cells against ER stress.{29136}
Brand:CaymanSKU:-Available on backorder
The unfolded protein response (UPR) maintains balance between protein synthesis and endoplasmic reticulum (ER) protein-folding by inhibiting translation to decrease global protein synthesis, increasing degradation and disposal of unfolded protein intermediates from the ER, and increasing the folding capacity of the ER by expanding its volume and increasing chaperone synthesis. Chronic ER stress leads to a defective UPR and is strongly associated with neurodegenerative diseases, cancers, and metabolic syndrome. Azoramide is a small molecule that has been shown to improve ER protein-folding ability by dose-dependently (1-25 µM) activating reporter genes whose expression is driven by the cellular UPR response element and the ER stress response element.{29136} At 1-25 µM, this compound can also stimulate the expression of multiple chaperone proteins to enhance ER chaperone capacity and induce phosphorylation of eukaryotic translation initiation factor 2α subunit (eIF2α) to reduce protein synthesis.{29136} At 150 mg/kg, azoramide exerts antidiabetic activity in both ob/ob and diet-induced obese mice, improving insulin sensitivity and glucose homeostasis, as well as protecting pancreatic β cells against ER stress.{29136}
Brand:CaymanSKU:-Available on backorder
The unfolded protein response (UPR) maintains balance between protein synthesis and endoplasmic reticulum (ER) protein-folding by inhibiting translation to decrease global protein synthesis, increasing degradation and disposal of unfolded protein intermediates from the ER, and increasing the folding capacity of the ER by expanding its volume and increasing chaperone synthesis. Chronic ER stress leads to a defective UPR and is strongly associated with neurodegenerative diseases, cancers, and metabolic syndrome. Azoramide is a small molecule that has been shown to improve ER protein-folding ability by dose-dependently (1-25 µM) activating reporter genes whose expression is driven by the cellular UPR response element and the ER stress response element.{29136} At 1-25 µM, this compound can also stimulate the expression of multiple chaperone proteins to enhance ER chaperone capacity and induce phosphorylation of eukaryotic translation initiation factor 2α subunit (eIF2α) to reduce protein synthesis.{29136} At 150 mg/kg, azoramide exerts antidiabetic activity in both ob/ob and diet-induced obese mice, improving insulin sensitivity and glucose homeostasis, as well as protecting pancreatic β cells against ER stress.{29136}
Brand:CaymanSKU:-Available on backorder
The unfolded protein response (UPR) maintains balance between protein synthesis and endoplasmic reticulum (ER) protein-folding by inhibiting translation to decrease global protein synthesis, increasing degradation and disposal of unfolded protein intermediates from the ER, and increasing the folding capacity of the ER by expanding its volume and increasing chaperone synthesis. Chronic ER stress leads to a defective UPR and is strongly associated with neurodegenerative diseases, cancers, and metabolic syndrome. Azoramide is a small molecule that has been shown to improve ER protein-folding ability by dose-dependently (1-25 µM) activating reporter genes whose expression is driven by the cellular UPR response element and the ER stress response element.{29136} At 1-25 µM, this compound can also stimulate the expression of multiple chaperone proteins to enhance ER chaperone capacity and induce phosphorylation of eukaryotic translation initiation factor 2α subunit (eIF2α) to reduce protein synthesis.{29136} At 150 mg/kg, azoramide exerts antidiabetic activity in both ob/ob and diet-induced obese mice, improving insulin sensitivity and glucose homeostasis, as well as protecting pancreatic β cells against ER stress.{29136}
Brand:CaymanSKU:-Available on backorder
Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide (LC95s = o site of the cytochrome bc1 complex and inhibiting electron transfer.{36648} Azoxystrobin is cytotoxic to MDA-kb2 cells with an EC20 value of 2.9 µM but has no antiandrogenic activity.{42005} It disrupts mRNA expression of antioxidant-, stress response-, and innate immune-related genes and induces the production of reactive oxygen species (ROS) in zebrafish larva when used at doses ranging from 0.1 to 100 µg/L.{36649} Azoxystrobin inhibits proliferation of KYSE-150 human esophageal squamous cell carcinoma cells (IC50 = 2.42 µg/ml after 48 hours) and induces apoptosis in a time- and dose-dependent manner.{36650} In a KYSE-150 nude mouse xenograft model, azoxystrobin reduces tumor growth when administered at a dose of 40 mg/kg per day.
Brand:CaymanSKU:24056 - 100 mgAvailable on backorder
Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide (LC95s = o site of the cytochrome bc1 complex and inhibiting electron transfer.{36648} Azoxystrobin is cytotoxic to MDA-kb2 cells with an EC20 value of 2.9 µM but has no antiandrogenic activity.{42005} It disrupts mRNA expression of antioxidant-, stress response-, and innate immune-related genes and induces the production of reactive oxygen species (ROS) in zebrafish larva when used at doses ranging from 0.1 to 100 µg/L.{36649} Azoxystrobin inhibits proliferation of KYSE-150 human esophageal squamous cell carcinoma cells (IC50 = 2.42 µg/ml after 48 hours) and induces apoptosis in a time- and dose-dependent manner.{36650} In a KYSE-150 nude mouse xenograft model, azoxystrobin reduces tumor growth when administered at a dose of 40 mg/kg per day.
Brand:CaymanSKU:24056 - 25 mgAvailable on backorder
Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide (LC95s = o site of the cytochrome bc1 complex and inhibiting electron transfer.{36648} Azoxystrobin is cytotoxic to MDA-kb2 cells with an EC20 value of 2.9 µM but has no antiandrogenic activity.{42005} It disrupts mRNA expression of antioxidant-, stress response-, and innate immune-related genes and induces the production of reactive oxygen species (ROS) in zebrafish larva when used at doses ranging from 0.1 to 100 µg/L.{36649} Azoxystrobin inhibits proliferation of KYSE-150 human esophageal squamous cell carcinoma cells (IC50 = 2.42 µg/ml after 48 hours) and induces apoptosis in a time- and dose-dependent manner.{36650} In a KYSE-150 nude mouse xenograft model, azoxystrobin reduces tumor growth when administered at a dose of 40 mg/kg per day.
Brand:CaymanSKU:24056 - 50 mgAvailable on backorder
Aztreonam is a synthetic β-lactam antibiotic of the monobactam class.{31705} It is active against clinical isolates of E. coli, S. marcescens, P. aeruginosa, Klebsiella species, Proteus species, and Enterobacter species (MICs = S. pneumoniae, B. fragilis, and S. faecalis (MICs = >100 µg/ml for all). It interferes with peptidoglycan synthesis in the bacterial cell wall of the Gram-negative bacteria E. coli, P. vulgaris, E. cloacae, K. pneumoniae, and P. aeruginosa by inhibiting penicillin-binding protein 3 (PBP3; IC100 = 0.1 µg/ml for all). It increases survival in mice with systemic Gram-negative bacterial infections (ED50s = 0.1-24.7 mg/kg). Formulations containing aztreonam have been used in the treatment of P. aeruginosa infections in individuals with cystic fibrosis.
Brand:CaymanSKU:19784 -Available on backorder
Aztreonam is a synthetic β-lactam antibiotic of the monobactam class.{31705} It is active against clinical isolates of E. coli, S. marcescens, P. aeruginosa, Klebsiella species, Proteus species, and Enterobacter species (MICs = S. pneumoniae, B. fragilis, and S. faecalis (MICs = >100 µg/ml for all). It interferes with peptidoglycan synthesis in the bacterial cell wall of the Gram-negative bacteria E. coli, P. vulgaris, E. cloacae, K. pneumoniae, and P. aeruginosa by inhibiting penicillin-binding protein 3 (PBP3; IC100 = 0.1 µg/ml for all). It increases survival in mice with systemic Gram-negative bacterial infections (ED50s = 0.1-24.7 mg/kg). Formulations containing aztreonam have been used in the treatment of P. aeruginosa infections in individuals with cystic fibrosis.
Brand:CaymanSKU:19784 -Available on backorder
Aztreonam is a synthetic β-lactam antibiotic of the monobactam class.{31705} It is active against clinical isolates of E. coli, S. marcescens, P. aeruginosa, Klebsiella species, Proteus species, and Enterobacter species (MICs = S. pneumoniae, B. fragilis, and S. faecalis (MICs = >100 µg/ml for all). It interferes with peptidoglycan synthesis in the bacterial cell wall of the Gram-negative bacteria E. coli, P. vulgaris, E. cloacae, K. pneumoniae, and P. aeruginosa by inhibiting penicillin-binding protein 3 (PBP3; IC100 = 0.1 µg/ml for all). It increases survival in mice with systemic Gram-negative bacterial infections (ED50s = 0.1-24.7 mg/kg). Formulations containing aztreonam have been used in the treatment of P. aeruginosa infections in individuals with cystic fibrosis.
Brand:CaymanSKU:19784 -Available on backorder
Aztreonam is a synthetic β-lactam antibiotic of the monobactam class.{31705} It is active against clinical isolates of E. coli, S. marcescens, P. aeruginosa, Klebsiella species, Proteus species, and Enterobacter species (MICs = S. pneumoniae, B. fragilis, and S. faecalis (MICs = >100 µg/ml for all). It interferes with peptidoglycan synthesis in the bacterial cell wall of the Gram-negative bacteria E. coli, P. vulgaris, E. cloacae, K. pneumoniae, and P. aeruginosa by inhibiting penicillin-binding protein 3 (PBP3; IC100 = 0.1 µg/ml for all). It increases survival in mice with systemic Gram-negative bacterial infections (ED50s = 0.1-24.7 mg/kg). Formulations containing aztreonam have been used in the treatment of P. aeruginosa infections in individuals with cystic fibrosis.
Brand:CaymanSKU:19784 -Available on backorder
Aztreonam-d6 is intended for use as an internal standard for the quantification of aztreonam (Item No. 19784) by GC- or LC-MS. Aztreonam is a synthetic β-lactam antibiotic of the monobactam class.{31705} It is active against clinical isolates of E. coli, S. marcescens, P. aeruginosa, Klebsiella species, Proteus species, and Enterobacter species (MICs = S. pneumoniae, B. fragilis, and S. faecalis (MICs = >100 µg/ml for all). It interferes with peptidoglycan synthesis in the bacterial cell wall of the Gram-negative bacteria E. coli, P. vulgaris, E. cloacae, K. pneumoniae, and P. aeruginosa by inhibiting penicillin-binding protein 3 (PBP3; IC100 = 0.1 µg/ml for all). It increases survival in mice with systemic Gram-negative bacterial infections (ED50s = 0.1-24.7 mg/kg). Formulations containing aztreonam have been used in the treatment of P. aeruginosa infections in individuals with cystic fibrosis.
Brand:CaymanSKU:28799 - 500 µgAvailable on backorder
Azumolene is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum.{27018,27021} It inhibits a component of store-operated calcium entry (SOCE) that is coupled to the skeletal muscle ryanodine receptor, with 20 µM azumolene causing a 70% reduction in SOCE in myotubes.{27020,27019} Azumolene has utility in countering muscle dysfunction associated with malignant hyperthermia.{27019}
Brand:CaymanSKU:-Out of stock
Azumolene is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum.{27018,27021} It inhibits a component of store-operated calcium entry (SOCE) that is coupled to the skeletal muscle ryanodine receptor, with 20 µM azumolene causing a 70% reduction in SOCE in myotubes.{27020,27019} Azumolene has utility in countering muscle dysfunction associated with malignant hyperthermia.{27019}
Brand:CaymanSKU:-Out of stock
Azumolene is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum.{27018,27021} It inhibits a component of store-operated calcium entry (SOCE) that is coupled to the skeletal muscle ryanodine receptor, with 20 µM azumolene causing a 70% reduction in SOCE in myotubes.{27020,27019} Azumolene has utility in countering muscle dysfunction associated with malignant hyperthermia.{27019}
Brand:CaymanSKU:-Out of stock
Proteasome-associated deubiquitinases (DUBs) release ubiquitin from proteasome-targeted ubiquitinated proteins, regenerating free ubiquitin.{25593} b-AP15 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs.{20322} It inhibits DUB activity in purified 19S proteasomes with an IC50 value of 2.1 µM.{20322} It exhibits little or no activity against several other DUBs.{20322} Through its effects on USP14 and UCHL5, b-AP15 blocks tumor progression in vivo in mice and prevents organ infiltration in mouse models of myeloid leukemia.{20322,25591} b-AP15 also renders tumor cells sensitive to TNF-mediated apoptosis by natural killer and T cells.{25592}
Brand:CaymanSKU:11324 - 1 mgAvailable on backorder
Proteasome-associated deubiquitinases (DUBs) release ubiquitin from proteasome-targeted ubiquitinated proteins, regenerating free ubiquitin.{25593} b-AP15 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs.{20322} It inhibits DUB activity in purified 19S proteasomes with an IC50 value of 2.1 µM.{20322} It exhibits little or no activity against several other DUBs.{20322} Through its effects on USP14 and UCHL5, b-AP15 blocks tumor progression in vivo in mice and prevents organ infiltration in mouse models of myeloid leukemia.{20322,25591} b-AP15 also renders tumor cells sensitive to TNF-mediated apoptosis by natural killer and T cells.{25592}
Brand:CaymanSKU:11324 - 10 mgAvailable on backorder
Proteasome-associated deubiquitinases (DUBs) release ubiquitin from proteasome-targeted ubiquitinated proteins, regenerating free ubiquitin.{25593} b-AP15 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs.{20322} It inhibits DUB activity in purified 19S proteasomes with an IC50 value of 2.1 µM.{20322} It exhibits little or no activity against several other DUBs.{20322} Through its effects on USP14 and UCHL5, b-AP15 blocks tumor progression in vivo in mice and prevents organ infiltration in mouse models of myeloid leukemia.{20322,25591} b-AP15 also renders tumor cells sensitive to TNF-mediated apoptosis by natural killer and T cells.{25592}
Brand:CaymanSKU:11324 - 25 mgAvailable on backorder