Cayman
Showing 10201–10350 of 45550 results
-
Arctigenin is an extract from A. lappa, a burdock plant traditionally used in Japanese Kampo medicine for its antioxidant, anti-inflammatory, antiproliferative, and antiviral activity. At 0.1 μM, arctigenin can block the activation of Akt induced by glucose starvation in pancreatic cancer PANC-1 cells, which is a key process in the tolerance exhibited by cancer cells to glucose starvation.{23767} It has potent in vitro antiviral activities against influenza A virus and shows neuroprotective effects against an experimental mouse model of Japanese encephalitis.{23769,23766} Arctigenin also demonstrates a therapeutic effect in ischemic stroke treatment of middle cerebral artery occluded rats by suppressing microglia activation and decreasing IL-1β and TNF-α expression.{23768}
Brand:CaymanSKU:- Arctigenin is an extract from A. lappa, a burdock plant traditionally used in Japanese Kampo medicine for its antioxidant, anti-inflammatory, antiproliferative, and antiviral activity. At 0.1 μM, arctigenin can block the activation of Akt induced by glucose starvation in pancreatic cancer PANC-1 cells, which is a key process in the tolerance exhibited by cancer cells to glucose starvation.{23767} It has potent in vitro antiviral activities against influenza A virus and shows neuroprotective effects against an experimental mouse model of Japanese encephalitis.{23769,23766} Arctigenin also demonstrates a therapeutic effect in ischemic stroke treatment of middle cerebral artery occluded rats by suppressing microglia activation and decreasing IL-1β and TNF-α expression.{23768}
Brand:CaymanSKU:- Arctigenin is an extract from A. lappa, a burdock plant traditionally used in Japanese Kampo medicine for its antioxidant, anti-inflammatory, antiproliferative, and antiviral activity. At 0.1 μM, arctigenin can block the activation of Akt induced by glucose starvation in pancreatic cancer PANC-1 cells, which is a key process in the tolerance exhibited by cancer cells to glucose starvation.{23767} It has potent in vitro antiviral activities against influenza A virus and shows neuroprotective effects against an experimental mouse model of Japanese encephalitis.{23769,23766} Arctigenin also demonstrates a therapeutic effect in ischemic stroke treatment of middle cerebral artery occluded rats by suppressing microglia activation and decreasing IL-1β and TNF-α expression.{23768}
Brand:CaymanSKU:- Arctigenin is an extract from A. lappa, a burdock plant traditionally used in Japanese Kampo medicine for its antioxidant, anti-inflammatory, antiproliferative, and antiviral activity. At 0.1 μM, arctigenin can block the activation of Akt induced by glucose starvation in pancreatic cancer PANC-1 cells, which is a key process in the tolerance exhibited by cancer cells to glucose starvation.{23767} It has potent in vitro antiviral activities against influenza A virus and shows neuroprotective effects against an experimental mouse model of Japanese encephalitis.{23769,23766} Arctigenin also demonstrates a therapeutic effect in ischemic stroke treatment of middle cerebral artery occluded rats by suppressing microglia activation and decreasing IL-1β and TNF-α expression.{23768}
Brand:CaymanSKU:-
Arctiin is the major active lignin in fruits of the burdock plant A. lappa. It demonstrates potent antiviral activity against influenza A virus and anti-inflammatory effects by decreasing the production of nitric oxide and pro-inflammatory cytokines.{23769,24978} Arctiin is metabolized by human intestinal bacteria into various bioactive metabolites including arctigenin (Item No. 14913) and enterolactone (Item No. 10112), which respectively exhibit growth inhibitory and growth promoting activity in MCF-7 breast cancer cells at 10 μM.{24977}
Brand:CaymanSKU:- Arctiin is the major active lignin in fruits of the burdock plant A. lappa. It demonstrates potent antiviral activity against influenza A virus and anti-inflammatory effects by decreasing the production of nitric oxide and pro-inflammatory cytokines.{23769,24978} Arctiin is metabolized by human intestinal bacteria into various bioactive metabolites including arctigenin (Item No. 14913) and enterolactone (Item No. 10112), which respectively exhibit growth inhibitory and growth promoting activity in MCF-7 breast cancer cells at 10 μM.{24977}
Brand:CaymanSKU:- Arctiin is the major active lignin in fruits of the burdock plant A. lappa. It demonstrates potent antiviral activity against influenza A virus and anti-inflammatory effects by decreasing the production of nitric oxide and pro-inflammatory cytokines.{23769,24978} Arctiin is metabolized by human intestinal bacteria into various bioactive metabolites including arctigenin (Item No. 14913) and enterolactone (Item No. 10112), which respectively exhibit growth inhibitory and growth promoting activity in MCF-7 breast cancer cells at 10 μM.{24977}
Brand:CaymanSKU:-
Arcyriaflavin A is an inhibitor of cyclin-dependent kinase 4 (CDK4; IC50 = 140 nM) and calcium/calmodulin-dependent protein kinase II (CaMKII; IC50 = 25 nM).{38695} It is selective for CDK4 and CaMKII over protein kinase A (PKA) and PKC (IC50s = >2 and >100 µM, respectively). In vitro, arcyriaflavin A inhibits replication of human cytomegalovirus (HCMV; IC50 = 200 nM), as well as proliferation of HCT116 and NCI H460 human carcinoma cells (IC50s = 850 and 590 nM, respectively).{38695,38696} It also inhibits proliferation and induces apoptosis of endometriotic cyst stromal cells (ECSCs).{38699}
Brand:CaymanSKU:- Arcyriaflavin A is an inhibitor of cyclin-dependent kinase 4 (CDK4; IC50 = 140 nM) and calcium/calmodulin-dependent protein kinase II (CaMKII; IC50 = 25 nM).{38695} It is selective for CDK4 and CaMKII over protein kinase A (PKA) and PKC (IC50s = >2 and >100 µM, respectively). In vitro, arcyriaflavin A inhibits replication of human cytomegalovirus (HCMV; IC50 = 200 nM), as well as proliferation of HCT116 and NCI H460 human carcinoma cells (IC50s = 850 and 590 nM, respectively).{38695,38696} It also inhibits proliferation and induces apoptosis of endometriotic cyst stromal cells (ECSCs).{38699}
Brand:CaymanSKU:- Arcyriaflavin A is an inhibitor of cyclin-dependent kinase 4 (CDK4; IC50 = 140 nM) and calcium/calmodulin-dependent protein kinase II (CaMKII; IC50 = 25 nM).{38695} It is selective for CDK4 and CaMKII over protein kinase A (PKA) and PKC (IC50s = >2 and >100 µM, respectively). In vitro, arcyriaflavin A inhibits replication of human cytomegalovirus (HCMV; IC50 = 200 nM), as well as proliferation of HCT116 and NCI H460 human carcinoma cells (IC50s = 850 and 590 nM, respectively).{38695,38696} It also inhibits proliferation and induces apoptosis of endometriotic cyst stromal cells (ECSCs).{38699}
Brand:CaymanSKU:-
Arecoline is a natural alkaloid that is found in the betel nut of the Areca palm. It is an agonist of the muscarinic acetylcholine receptors with EC50 values of 7, 95, 11, 410, and 69 nM for M1, M2, M3, M4, and M5, respectively.{18340,18339,19164} Generally, arecoline causes smooth muscle contraction.{18340,18343,18342} Arecoline and other muscarinic receptor agonists have been shown to improve learning and memory and may prove to be useful in treating dementia.{18345,18341,18344}
Brand:CaymanSKU:- Arecoline is a natural alkaloid that is found in the betel nut of the Areca palm. It is an agonist of the muscarinic acetylcholine receptors with EC50 values of 7, 95, 11, 410, and 69 nM for M1, M2, M3, M4, and M5, respectively.{18340,18339,19164} Generally, arecoline causes smooth muscle contraction.{18340,18343,18342} Arecoline and other muscarinic receptor agonists have been shown to improve learning and memory and may prove to be useful in treating dementia.{18345,18341,18344}
Brand:CaymanSKU:- Arecoline is a natural alkaloid that is found in the betel nut of the Areca palm. It is an agonist of the muscarinic acetylcholine receptors with EC50 values of 7, 95, 11, 410, and 69 nM for M1, M2, M3, M4, and M5, respectively.{18340,18339,19164} Generally, arecoline causes smooth muscle contraction.{18340,18343,18342} Arecoline and other muscarinic receptor agonists have been shown to improve learning and memory and may prove to be useful in treating dementia.{18345,18341,18344}
Brand:CaymanSKU:-
Arenobufagin is a cardiotonic steroid that has been found in the skin secretions of the toad B. gargarizans and has anticancer activity.{52655,52656,42766,52657} It inhibits Na+/K+-ATPase activity in isolated guinea pig ventricular myocytes with an IC50 value of 290 nM.{52655} Arenobufagin (20-500 nM) induces cleavage of poly(ADP-ribose) polymerase (PARP), caspase-3, and caspase-9, as well as induces apoptosis in HepG2 hepatocellular carcinoma cells.{52656} It inhibits proliferation of HepG2, Hep3B, BEL-7402, and MCF-7 cancer cells (IC50s = 101.9, 39.8, 416.3, and 143.7 nM, respectively), as well as multidrug-resistant HepG2/adm and MCF-7/adr cancer cells (IC50s = 730 and 67.5 nM, respectively). Arenobufagin (1 mg/kg once per day, i.v.) reduces tumor growth, the number and size of lung metastases, and tumor levels of the epithelial-to-mesenchymal transition (EMT) markers vimentin and β-catenin in a PC3 mouse xenograft model.{42766} Arenobufagin (5 and 10 µM/plug) inhibits VEGF-induced angiogenesis in a Matrigel™ plug assay in mice.{52657}
Brand:CaymanSKU:30695 - 1 mgAvailable on backorder
Arenobufagin is a cardiotonic steroid that has been found in the skin secretions of the toad B. gargarizans and has anticancer activity.{52655,52656,42766,52657} It inhibits Na+/K+-ATPase activity in isolated guinea pig ventricular myocytes with an IC50 value of 290 nM.{52655} Arenobufagin (20-500 nM) induces cleavage of poly(ADP-ribose) polymerase (PARP), caspase-3, and caspase-9, as well as induces apoptosis in HepG2 hepatocellular carcinoma cells.{52656} It inhibits proliferation of HepG2, Hep3B, BEL-7402, and MCF-7 cancer cells (IC50s = 101.9, 39.8, 416.3, and 143.7 nM, respectively), as well as multidrug-resistant HepG2/adm and MCF-7/adr cancer cells (IC50s = 730 and 67.5 nM, respectively). Arenobufagin (1 mg/kg once per day, i.v.) reduces tumor growth, the number and size of lung metastases, and tumor levels of the epithelial-to-mesenchymal transition (EMT) markers vimentin and β-catenin in a PC3 mouse xenograft model.{42766} Arenobufagin (5 and 10 µM/plug) inhibits VEGF-induced angiogenesis in a Matrigel™ plug assay in mice.{52657}
Brand:CaymanSKU:30695 - 10 mgAvailable on backorder
Arenobufagin is a cardiotonic steroid that has been found in the skin secretions of the toad B. gargarizans and has anticancer activity.{52655,52656,42766,52657} It inhibits Na+/K+-ATPase activity in isolated guinea pig ventricular myocytes with an IC50 value of 290 nM.{52655} Arenobufagin (20-500 nM) induces cleavage of poly(ADP-ribose) polymerase (PARP), caspase-3, and caspase-9, as well as induces apoptosis in HepG2 hepatocellular carcinoma cells.{52656} It inhibits proliferation of HepG2, Hep3B, BEL-7402, and MCF-7 cancer cells (IC50s = 101.9, 39.8, 416.3, and 143.7 nM, respectively), as well as multidrug-resistant HepG2/adm and MCF-7/adr cancer cells (IC50s = 730 and 67.5 nM, respectively). Arenobufagin (1 mg/kg once per day, i.v.) reduces tumor growth, the number and size of lung metastases, and tumor levels of the epithelial-to-mesenchymal transition (EMT) markers vimentin and β-catenin in a PC3 mouse xenograft model.{42766} Arenobufagin (5 and 10 µM/plug) inhibits VEGF-induced angiogenesis in a Matrigel™ plug assay in mice.{52657}
Brand:CaymanSKU:30695 - 5 mgAvailable on backorder
Aformoterol is the (R,R)-enantiomer of the β2-adrenergic receptor (β2-AR) agonist formoterol (Item No. 15584).{43065} It selectively binds to β1- over β2-ARs (Kds = 2.9 and 113 nM, respectively) as well as β3-adrenergic, B2 bradykinin, neurokinin 1 (NK1) and NK2 receptors when used at concentrations up to 3 μM. Aformoterol induces cAMP accumulation in cultured human bronchial epithelial cells. Ex vivo, aformoterol (0.01-1,000 nM) induces dose-dependent relaxation of guinea pig tracheal strips precontracted with carbamoylcholine (Item No. 14486), ovalbumin, or histamine (pD2s = 8.4, 9.5, and 9.5, respectively). In vivo, aformoterol reverses histamine- and ovalbumin-induced bronchoconstriction in guinea pigs (ED50s = 1 and 40 nmol/kg, respectively). Formulations containing aformoterol have been used in the treatment of chronic obstructive pulmonary disease (COPD).
Brand:CaymanSKU:23935 - 10 mgAvailable on backorder
Aformoterol is the (R,R)-enantiomer of the β2-adrenergic receptor (β2-AR) agonist formoterol (Item No. 15584).{43065} It selectively binds to β1- over β2-ARs (Kds = 2.9 and 113 nM, respectively) as well as β3-adrenergic, B2 bradykinin, neurokinin 1 (NK1) and NK2 receptors when used at concentrations up to 3 μM. Aformoterol induces cAMP accumulation in cultured human bronchial epithelial cells. Ex vivo, aformoterol (0.01-1,000 nM) induces dose-dependent relaxation of guinea pig tracheal strips precontracted with carbamoylcholine (Item No. 14486), ovalbumin, or histamine (pD2s = 8.4, 9.5, and 9.5, respectively). In vivo, aformoterol reverses histamine- and ovalbumin-induced bronchoconstriction in guinea pigs (ED50s = 1 and 40 nmol/kg, respectively). Formulations containing aformoterol have been used in the treatment of chronic obstructive pulmonary disease (COPD).
Brand:CaymanSKU:23935 - 25 mgAvailable on backorder
Aformoterol is the (R,R)-enantiomer of the β2-adrenergic receptor (β2-AR) agonist formoterol (Item No. 15584).{43065} It selectively binds to β1- over β2-ARs (Kds = 2.9 and 113 nM, respectively) as well as β3-adrenergic, B2 bradykinin, neurokinin 1 (NK1) and NK2 receptors when used at concentrations up to 3 μM. Aformoterol induces cAMP accumulation in cultured human bronchial epithelial cells. Ex vivo, aformoterol (0.01-1,000 nM) induces dose-dependent relaxation of guinea pig tracheal strips precontracted with carbamoylcholine (Item No. 14486), ovalbumin, or histamine (pD2s = 8.4, 9.5, and 9.5, respectively). In vivo, aformoterol reverses histamine- and ovalbumin-induced bronchoconstriction in guinea pigs (ED50s = 1 and 40 nmol/kg, respectively). Formulations containing aformoterol have been used in the treatment of chronic obstructive pulmonary disease (COPD).
Brand:CaymanSKU:23935 - 5 mgAvailable on backorder
Aformoterol is the (R,R)-enantiomer of the β2-adrenergic receptor (β2-AR) agonist formoterol (Item No. 15584).{43065} It selectively binds to β1- over β2-ARs (Kds = 2.9 and 113 nM, respectively) as well as β3-adrenergic, B2 bradykinin, neurokinin 1 (NK1) and NK2 receptors when used at concentrations up to 3 μM. Aformoterol induces cAMP accumulation in cultured human bronchial epithelial cells. Ex vivo, aformoterol (0.01-1,000 nM) induces dose-dependent relaxation of guinea pig tracheal strips precontracted with carbamoylcholine (Item No. 14486), ovalbumin, or histamine (pD2s = 8.4, 9.5, and 9.5, respectively). In vivo, aformoterol reverses histamine- and ovalbumin-induced bronchoconstriction in guinea pigs (ED50s = 1 and 40 nmol/kg, respectively). Formulations containing aformoterol have been used in the treatment of chronic obstructive pulmonary disease (COPD).
Brand:CaymanSKU:23935 - 50 mgAvailable on backorder
Arg-Gly-Asp (RGD) is a synthetic peptide corresponding to the cell adhesion sequence for the integrins αVβ1, αVβ3, αVβ5, αVβ6, αVβ8, α8β1, and α5β1.{57283,57284} It is a component of radioligands and peptidomimetics that have been used in the study of integrin expression and activity in vivo.{57284,57285}
Brand:CaymanSKU:31369 - 10 mgAvailable on backorder
Arg-Gly-Asp (RGD) is a synthetic peptide corresponding to the cell adhesion sequence for the integrins αVβ1, αVβ3, αVβ5, αVβ6, αVβ8, α8β1, and α5β1.{57283,57284} It is a component of radioligands and peptidomimetics that have been used in the study of integrin expression and activity in vivo.{57284,57285}
Brand:CaymanSKU:31369 - 25 mgAvailable on backorder
Arg-Gly-Asp (RGD) is a synthetic peptide corresponding to the cell adhesion sequence for the integrins αVβ1, αVβ3, αVβ5, αVβ6, αVβ8, α8β1, and α5β1.{57283,57284} It is a component of radioligands and peptidomimetics that have been used in the study of integrin expression and activity in vivo.{57284,57285}
Brand:CaymanSKU:31369 - 5 mgAvailable on backorder
Arg-Gly-Asp (RGD) is a synthetic peptide corresponding to the cell adhesion sequence for the integrins αVβ1, αVβ3, αVβ5, αVβ6, αVβ8, α8β1, and α5β1.{57283,57284} It is a component of radioligands and peptidomimetics that have been used in the study of integrin expression and activity in vivo.{57284,57285}
Brand:CaymanSKU:31369 - 50 mgAvailable on backorder
Argatroban is a reversible inhibitor of thrombin (IC50s = 0.01 and 0.09 µM for the free and clot-bound forms, respectively).{31477} It is selective for thrombin over factor Xa, trypsin, plasmin, and tissue plasminogen activator (Kis = 0.0045, 53, 0.19, 25.7, and 87.7 µM, respectively). It inhibits thrombin-induced platelet aggregation in washed isolated guinea pig platelets with an IC50 value of 0.077 µM.{54177} Argatroban (3.2 mg/kg, s.c.) decreases thrombus formation in a guinea pig model of iron chloride-induced arterial thrombosis. Formulations containing argatroban have been used in the prevention or treatment of thrombosis in patients with heparin-induced thrombocytopenia.
Brand:CaymanSKU:19639 -Available on backorder
Argatroban is a reversible inhibitor of thrombin (IC50s = 0.01 and 0.09 µM for the free and clot-bound forms, respectively).{31477} It is selective for thrombin over factor Xa, trypsin, plasmin, and tissue plasminogen activator (Kis = 0.0045, 53, 0.19, 25.7, and 87.7 µM, respectively). It inhibits thrombin-induced platelet aggregation in washed isolated guinea pig platelets with an IC50 value of 0.077 µM.{54177} Argatroban (3.2 mg/kg, s.c.) decreases thrombus formation in a guinea pig model of iron chloride-induced arterial thrombosis. Formulations containing argatroban have been used in the prevention or treatment of thrombosis in patients with heparin-induced thrombocytopenia.
Brand:CaymanSKU:19639 -Available on backorder
Argatroban is a reversible inhibitor of thrombin (IC50s = 0.01 and 0.09 µM for the free and clot-bound forms, respectively).{31477} It is selective for thrombin over factor Xa, trypsin, plasmin, and tissue plasminogen activator (Kis = 0.0045, 53, 0.19, 25.7, and 87.7 µM, respectively). It inhibits thrombin-induced platelet aggregation in washed isolated guinea pig platelets with an IC50 value of 0.077 µM.{54177} Argatroban (3.2 mg/kg, s.c.) decreases thrombus formation in a guinea pig model of iron chloride-induced arterial thrombosis. Formulations containing argatroban have been used in the prevention or treatment of thrombosis in patients with heparin-induced thrombocytopenia.
Brand:CaymanSKU:19639 -Available on backorder
Argatroban is a reversible inhibitor of thrombin (IC50s = 0.01 and 0.09 µM for the free and clot-bound forms, respectively).{31477} It is selective for thrombin over factor Xa, trypsin, plasmin, and tissue plasminogen activator (Kis = 0.0045, 53, 0.19, 25.7, and 87.7 µM, respectively). It inhibits thrombin-induced platelet aggregation in washed isolated guinea pig platelets with an IC50 value of 0.077 µM.{54177} Argatroban (3.2 mg/kg, s.c.) decreases thrombus formation in a guinea pig model of iron chloride-induced arterial thrombosis. Formulations containing argatroban have been used in the prevention or treatment of thrombosis in patients with heparin-induced thrombocytopenia.
Brand:CaymanSKU:19639 -Available on backorder
Argatroban-d3 is intended for use as an internal standard for the quantification of argatroban (Item No. 19639) by GC- or LC-MS. Argatroban is a reversible inhibitor of thrombin (IC50s = 0.01 and 0.09 µM for the free and clot-bound forms, respectively).{31477} It is selective for thrombin over factor Xa, trypsin, plasmin, and tissue plasminogen activator (Kis = 0.0045, 53, 0.19, 25.7, and 87.7 µM, respectively). It inhibits thrombin-induced platelet aggregation in washed isolated guinea pig platelets with an IC50 value of 0.077 µM.{54177} Argatroban (3.2 mg/kg, s.c.) decreases thrombus formation in a guinea pig model of iron chloride-induced arterial thrombosis. Formulations containing argatroban have been used in the prevention or treatment of thrombosis in patients with heparin-induced thrombocytopenia.
Brand:CaymanSKU:25757 - 1 mgAvailable on backorder
Argatroban-d3 is intended for use as an internal standard for the quantification of argatroban (Item No. 19639) by GC- or LC-MS. Argatroban is a reversible inhibitor of thrombin (IC50s = 0.01 and 0.09 µM for the free and clot-bound forms, respectively).{31477} It is selective for thrombin over factor Xa, trypsin, plasmin, and tissue plasminogen activator (Kis = 0.0045, 53, 0.19, 25.7, and 87.7 µM, respectively). It inhibits thrombin-induced platelet aggregation in washed isolated guinea pig platelets with an IC50 value of 0.077 µM.{54177} Argatroban (3.2 mg/kg, s.c.) decreases thrombus formation in a guinea pig model of iron chloride-induced arterial thrombosis. Formulations containing argatroban have been used in the prevention or treatment of thrombosis in patients with heparin-induced thrombocytopenia.
Brand:CaymanSKU:25757 - 5 mgAvailable on backorder
Arginase inhibitor 1 is an inhibitor of arginase I and II (IC50s = 223 and 509 nM, respectively, for the recombinant human enzymes).{50100} It decreases arginase I activity in CHOK cells expressing human arginase I (IC50 = 8 µM). Arginase inhibitor 1 (100 mg/kg, i.v.) reduces infarct size in a rat model of myocardial ischemia and reperfusion injury induced by left-main coronary artery occlusion.
Brand:CaymanSKU:28418 - 1 mgAvailable on backorder
Arginase inhibitor 1 is an inhibitor of arginase I and II (IC50s = 223 and 509 nM, respectively, for the recombinant human enzymes).{50100} It decreases arginase I activity in CHOK cells expressing human arginase I (IC50 = 8 µM). Arginase inhibitor 1 (100 mg/kg, i.v.) reduces infarct size in a rat model of myocardial ischemia and reperfusion injury induced by left-main coronary artery occlusion.
Brand:CaymanSKU:28418 - 5 mgAvailable on backorder
Argipressin is a peptide hormone with vasoconstrictive and antidiuretic activities that binds to the vascular arginine vasopressin receptor, V1, with Kd values of 1.31 and 1.44 nM in A7r5 rat aortic smooth muscle cells and neonatal rat cardiomyocytes, respectively.{38625,38626} It also stimulates the intracellular release of calcium in A7r5 cells (EC50 = 5 nM).{38623} In rat models, argipressin induces hypertension and tachycardia when injected into the lateral septal nuclei at a dose of 100-400 ng and increases heart rate and mean arterial pressure (MAP) when injected into the medial amygdaloid body at a dose of 150-600 ng.{38624,38622}
Brand:CaymanSKU:24154 - 1 mgAvailable on backorder
Arglabin is a sesquiterpene γ-lactone originally isolated from A. glabella that has anticancer and anti-inflammatory activities.{45407} It inhibits the growth of LS-180, SSC-4, HeLa, MCF-7, and HL-60 cancer cells (IC50s = 20, 10, 20, 20, and 50 µM, respectively).{45408} Arglabin reduces tumor growth in an SCC-4 mouse xenograft model when administered at a dose of 40 µg/g. It is a selective inhibitor of the NLRP3 inflammasome over the NLRP1, AIM2, and NLRC4 inflammasomes when used at a concentration of 50 nM.{45407} Arglabin (50 nM) reduces increases in protein levels of NLRP3, caspase-1, IL-1β, and IL-18 induced by cholesterol crystals in LPS-primed mouse peritoneal macrophages. It decreases plasma levels of IL-1β, oxidized LDL autoantibodies, total cholesterol, and triglycerides, and reduces the size of atherosclerotic lesions in the aorta of mice fed a high-fat diet when administered at a dose of 2.5 ng/g.
Brand:CaymanSKU:-Available on backorder
Arglabin is a sesquiterpene γ-lactone originally isolated from A. glabella that has anticancer and anti-inflammatory activities.{45407} It inhibits the growth of LS-180, SSC-4, HeLa, MCF-7, and HL-60 cancer cells (IC50s = 20, 10, 20, 20, and 50 µM, respectively).{45408} Arglabin reduces tumor growth in an SCC-4 mouse xenograft model when administered at a dose of 40 µg/g. It is a selective inhibitor of the NLRP3 inflammasome over the NLRP1, AIM2, and NLRC4 inflammasomes when used at a concentration of 50 nM.{45407} Arglabin (50 nM) reduces increases in protein levels of NLRP3, caspase-1, IL-1β, and IL-18 induced by cholesterol crystals in LPS-primed mouse peritoneal macrophages. It decreases plasma levels of IL-1β, oxidized LDL autoantibodies, total cholesterol, and triglycerides, and reduces the size of atherosclerotic lesions in the aorta of mice fed a high-fat diet when administered at a dose of 2.5 ng/g.
Brand:CaymanSKU:-Available on backorder
Arglabin is a sesquiterpene γ-lactone originally isolated from A. glabella that has anticancer and anti-inflammatory activities.{45407} It inhibits the growth of LS-180, SSC-4, HeLa, MCF-7, and HL-60 cancer cells (IC50s = 20, 10, 20, 20, and 50 µM, respectively).{45408} Arglabin reduces tumor growth in an SCC-4 mouse xenograft model when administered at a dose of 40 µg/g. It is a selective inhibitor of the NLRP3 inflammasome over the NLRP1, AIM2, and NLRC4 inflammasomes when used at a concentration of 50 nM.{45407} Arglabin (50 nM) reduces increases in protein levels of NLRP3, caspase-1, IL-1β, and IL-18 induced by cholesterol crystals in LPS-primed mouse peritoneal macrophages. It decreases plasma levels of IL-1β, oxidized LDL autoantibodies, total cholesterol, and triglycerides, and reduces the size of atherosclerotic lesions in the aorta of mice fed a high-fat diet when administered at a dose of 2.5 ng/g.
Brand:CaymanSKU:-Available on backorder
Aripiprazole is an atypical antipsychotic.{47557} It is a partial agonist at dopamine D2, D2L, and D3 receptors (Kis = 3.3, 0.74, 9.7 nM, respectively), a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 5.6 nM), and an inverse agonist of 5-HT2B receptors (Ki = 0.36 nM). It is functionally selective at the dopamine D2 receptor with cell-type- and function-selective activities. Aripiprazole inhibits disruptions in prepulse inhibition induced by phencyclidine in mice when administered at doses of 5 and 10 mg/kg.{47558} Formulations containing aripiprazole have been used in the treatment of schizophrenia, bipolar mania or mixed episodes, and Tourette’s disorder.
Brand:CaymanSKU:19989 -Available on backorder
Aripiprazole is an atypical antipsychotic.{47557} It is a partial agonist at dopamine D2, D2L, and D3 receptors (Kis = 3.3, 0.74, 9.7 nM, respectively), a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 5.6 nM), and an inverse agonist of 5-HT2B receptors (Ki = 0.36 nM). It is functionally selective at the dopamine D2 receptor with cell-type- and function-selective activities. Aripiprazole inhibits disruptions in prepulse inhibition induced by phencyclidine in mice when administered at doses of 5 and 10 mg/kg.{47558} Formulations containing aripiprazole have been used in the treatment of schizophrenia, bipolar mania or mixed episodes, and Tourette’s disorder.
Brand:CaymanSKU:19989 -Available on backorder
Aripiprazole is an atypical antipsychotic.{47557} It is a partial agonist at dopamine D2, D2L, and D3 receptors (Kis = 3.3, 0.74, 9.7 nM, respectively), a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 5.6 nM), and an inverse agonist of 5-HT2B receptors (Ki = 0.36 nM). It is functionally selective at the dopamine D2 receptor with cell-type- and function-selective activities. Aripiprazole inhibits disruptions in prepulse inhibition induced by phencyclidine in mice when administered at doses of 5 and 10 mg/kg.{47558} Formulations containing aripiprazole have been used in the treatment of schizophrenia, bipolar mania or mixed episodes, and Tourette’s disorder.
Brand:CaymanSKU:19989 -Available on backorder
Aripiprazole is an atypical antipsychotic.{47557} It is a partial agonist at dopamine D2, D2L, and D3 receptors (Kis = 3.3, 0.74, 9.7 nM, respectively), a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 5.6 nM), and an inverse agonist of 5-HT2B receptors (Ki = 0.36 nM). It is functionally selective at the dopamine D2 receptor with cell-type- and function-selective activities. Aripiprazole inhibits disruptions in prepulse inhibition induced by phencyclidine in mice when administered at doses of 5 and 10 mg/kg.{47558} Formulations containing aripiprazole have been used in the treatment of schizophrenia, bipolar mania or mixed episodes, and Tourette’s disorder.
Brand:CaymanSKU:19989 -Available on backorder
Aripiprazole-d8 is intended for use as an internal standard for the quantification of aripiprazole (Item No. 19989) by GC- or LC-MS. Aripiprazole is an atypical antipsychotic.{47557} It is a partial agonist at dopamine D2, D2L, and D3 receptors (Kis = 3.3, 0.74, 9.7 nM, respectively), a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 5.6 nM), and an inverse agonist of 5-HT2B receptors (Ki = 0.36 nM). It is functionally selective at the dopamine D2 receptor with cell-type- and function-selective activities. Aripiprazole inhibits disruptions in prepulse inhibition induced by phencyclidine in mice when administered at doses of 5 and 10 mg/kg.{47558} Formulations containing aripiprazole have been used in the treatment of schizophrenia, bipolar mania or mixed episodes, and Tourette’s disorder.
Brand:CaymanSKU:28487 - 1 mgAvailable on backorder
Aristolochic acid is an alkaloid originally isolated from A. radix that inhibits inflammatory phospholipase A2 (PLA2) activity (IC50 = 40 µM in human neutrophils).{34789} It inhibits human synovial fluid PLA2-induced edema in a dose-dependent manner in vivo which positively correlates with in vitro inhibition of PLA2.{812} Aristolochic acid inhibits hemolytic activity of PLA2s TFV PL-X, TFV PL-Ia, and TFV PL-Ib from T. flavoviridis venom (IC50s = 4.6, 4.0, and 3.9 µM, respectively) but enhances the edema-inducing activity of TFV PL-Ia and TFV PL-Ib.{667} Aristolochic acid exposure is also associated with progressive interstitial fibrosing nephropathy and upper urinary tract urothelial carcinomas.{34790}
Brand:CaymanSKU:21520 -Out of stock
Aristolochic acid is an alkaloid originally isolated from A. radix that inhibits inflammatory phospholipase A2 (PLA2) activity (IC50 = 40 µM in human neutrophils).{34789} It inhibits human synovial fluid PLA2-induced edema in a dose-dependent manner in vivo which positively correlates with in vitro inhibition of PLA2.{812} Aristolochic acid inhibits hemolytic activity of PLA2s TFV PL-X, TFV PL-Ia, and TFV PL-Ib from T. flavoviridis venom (IC50s = 4.6, 4.0, and 3.9 µM, respectively) but enhances the edema-inducing activity of TFV PL-Ia and TFV PL-Ib.{667} Aristolochic acid exposure is also associated with progressive interstitial fibrosing nephropathy and upper urinary tract urothelial carcinomas.{34790}
Brand:CaymanSKU:21520 -Out of stock
Aristolochic acid is an alkaloid originally isolated from A. radix that inhibits inflammatory phospholipase A2 (PLA2) activity (IC50 = 40 µM in human neutrophils).{34789} It inhibits human synovial fluid PLA2-induced edema in a dose-dependent manner in vivo which positively correlates with in vitro inhibition of PLA2.{812} Aristolochic acid inhibits hemolytic activity of PLA2s TFV PL-X, TFV PL-Ia, and TFV PL-Ib from T. flavoviridis venom (IC50s = 4.6, 4.0, and 3.9 µM, respectively) but enhances the edema-inducing activity of TFV PL-Ia and TFV PL-Ib.{667} Aristolochic acid exposure is also associated with progressive interstitial fibrosing nephropathy and upper urinary tract urothelial carcinomas.{34790}
Brand:CaymanSKU:21520 -Out of stock
Aristolochic acid is an alkaloid originally isolated from A. radix that inhibits inflammatory phospholipase A2 (PLA2) activity (IC50 = 40 µM in human neutrophils).{34789} It inhibits human synovial fluid PLA2-induced edema in a dose-dependent manner in vivo which positively correlates with in vitro inhibition of PLA2.{812} Aristolochic acid inhibits hemolytic activity of PLA2s TFV PL-X, TFV PL-Ia, and TFV PL-Ib from T. flavoviridis venom (IC50s = 4.6, 4.0, and 3.9 µM, respectively) but enhances the edema-inducing activity of TFV PL-Ia and TFV PL-Ib.{667} Aristolochic acid exposure is also associated with progressive interstitial fibrosing nephropathy and upper urinary tract urothelial carcinomas.{34790}
Brand:CaymanSKU:21520 -Out of stock
Aristolochic acid B is an alkaloid that has been found in Aristolochia with mutagenic activity.{45593} It forms DNA adducts under anaerobic conditions in vitro when used at a concentration of 0.4 mM. Oral administration of aristolochic acid B (0.03 mmol/kg) induces bladder, forestomach, and kidney DNA adduct formation in rats. Aristolochic acid B reduces body weight and urine concentrations of sodium, potassium, and calcium, enlarges the liver and kidneys, and increases blood concentrations of hemoglobin and hematocrit in rats.{45594}
Brand:CaymanSKU:28504 - 1 mgAvailable on backorder
Aristolochic acid B is an alkaloid that has been found in Aristolochia with mutagenic activity.{45593} It forms DNA adducts under anaerobic conditions in vitro when used at a concentration of 0.4 mM. Oral administration of aristolochic acid B (0.03 mmol/kg) induces bladder, forestomach, and kidney DNA adduct formation in rats. Aristolochic acid B reduces body weight and urine concentrations of sodium, potassium, and calcium, enlarges the liver and kidneys, and increases blood concentrations of hemoglobin and hematocrit in rats.{45594}
Brand:CaymanSKU:28504 - 10 mgAvailable on backorder
Aristolochic acid B is an alkaloid that has been found in Aristolochia with mutagenic activity.{45593} It forms DNA adducts under anaerobic conditions in vitro when used at a concentration of 0.4 mM. Oral administration of aristolochic acid B (0.03 mmol/kg) induces bladder, forestomach, and kidney DNA adduct formation in rats. Aristolochic acid B reduces body weight and urine concentrations of sodium, potassium, and calcium, enlarges the liver and kidneys, and increases blood concentrations of hemoglobin and hematocrit in rats.{45594}
Brand:CaymanSKU:28504 - 5 mgAvailable on backorder
Aristolochic acid C is an alkaloid originally isolated from Aristolochia argentina and a derivative of aristolochic acid (Item No. 21520) that has anticancer activities.{46438,46439,46440} It inhibits the growth of LLC-PK1, P388, HT-29, and HL-60 cancer cells (IC50s = 85, 8.8, 17.1, and 40 µM, respectively).{46438,46439}
Brand:CaymanSKU:28505 - 1 mgAvailable on backorder
Aristolochic acid C is an alkaloid originally isolated from Aristolochia argentina and a derivative of aristolochic acid (Item No. 21520) that has anticancer activities.{46438,46439,46440} It inhibits the growth of LLC-PK1, P388, HT-29, and HL-60 cancer cells (IC50s = 85, 8.8, 17.1, and 40 µM, respectively).{46438,46439}
Brand:CaymanSKU:28505 - 10 mgAvailable on backorder
Aristolochic acid C is an alkaloid originally isolated from Aristolochia argentina and a derivative of aristolochic acid (Item No. 21520) that has anticancer activities.{46438,46439,46440} It inhibits the growth of LLC-PK1, P388, HT-29, and HL-60 cancer cells (IC50s = 85, 8.8, 17.1, and 40 µM, respectively).{46438,46439}
Brand:CaymanSKU:28505 - 5 mgAvailable on backorder
Arjunolic acid is a triterpene that has been found in T. arjuna and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties.{53190,53191,53192} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay when used at a concentration of 0.8 mM.{53190} Arjunolic acid (20 mg/kg for four days) prevents arsenic-induced decreases in the activity of superoxide dismutase (SOD1), catalase, GST, and glutathione reductase in mouse brain. It reduces tumor growth in an Ehrlich murine spontaneous adenocarcinoma model when administered at doses of 100 and 250 mg/kg for 20 days.{53191} Arjunolic acid reduces renal fibrosis and increases in kidney TNF-α and IL-1β levels induced by cisplatin (Item No. 13119) in mice when administered at doses of 100 and 250 mg/kg per day for 10 days.{53192}
Brand:CaymanSKU:29438 - 1 mgAvailable on backorder
Arjunolic acid is a triterpene that has been found in T. arjuna and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties.{53190,53191,53192} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay when used at a concentration of 0.8 mM.{53190} Arjunolic acid (20 mg/kg for four days) prevents arsenic-induced decreases in the activity of superoxide dismutase (SOD1), catalase, GST, and glutathione reductase in mouse brain. It reduces tumor growth in an Ehrlich murine spontaneous adenocarcinoma model when administered at doses of 100 and 250 mg/kg for 20 days.{53191} Arjunolic acid reduces renal fibrosis and increases in kidney TNF-α and IL-1β levels induced by cisplatin (Item No. 13119) in mice when administered at doses of 100 and 250 mg/kg per day for 10 days.{53192}
Brand:CaymanSKU:29438 - 10 mgAvailable on backorder
Arjunolic acid is a triterpene that has been found in T. arjuna and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties.{53190,53191,53192} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay when used at a concentration of 0.8 mM.{53190} Arjunolic acid (20 mg/kg for four days) prevents arsenic-induced decreases in the activity of superoxide dismutase (SOD1), catalase, GST, and glutathione reductase in mouse brain. It reduces tumor growth in an Ehrlich murine spontaneous adenocarcinoma model when administered at doses of 100 and 250 mg/kg for 20 days.{53191} Arjunolic acid reduces renal fibrosis and increases in kidney TNF-α and IL-1β levels induced by cisplatin (Item No. 13119) in mice when administered at doses of 100 and 250 mg/kg per day for 10 days.{53192}
Brand:CaymanSKU:29438 - 5 mgAvailable on backorder
Arjunolic acid is a triterpene that has been found in T. arjuna and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties.{53190,53191,53192} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay when used at a concentration of 0.8 mM.{53190} Arjunolic acid (20 mg/kg for four days) prevents arsenic-induced decreases in the activity of superoxide dismutase (SOD1), catalase, GST, and glutathione reductase in mouse brain. It reduces tumor growth in an Ehrlich murine spontaneous adenocarcinoma model when administered at doses of 100 and 250 mg/kg for 20 days.{53191} Arjunolic acid reduces renal fibrosis and increases in kidney TNF-α and IL-1β levels induced by cisplatin (Item No. 13119) in mice when administered at doses of 100 and 250 mg/kg per day for 10 days.{53192}
Brand:CaymanSKU:29438 - 500 µgAvailable on backorder
Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 (Item No. 20110) from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro.{12673,20329} ARM1 is a thiazolamine that inhibits LTB4 synthesis in human neutrophils (IC50 = ~0.5 µM) and conversion of LTA4 to LTB4 by purified LTA4 hydrolase (Ki = 2.3 µM).{25663} ARM1 does not significantly affect the hydrolysis of Pro-Gly-Pro by LTA4 hydrolase.{25663}
Brand:CaymanSKU:- Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 (Item No. 20110) from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro.{12673,20329} ARM1 is a thiazolamine that inhibits LTB4 synthesis in human neutrophils (IC50 = ~0.5 µM) and conversion of LTA4 to LTB4 by purified LTA4 hydrolase (Ki = 2.3 µM).{25663} ARM1 does not significantly affect the hydrolysis of Pro-Gly-Pro by LTA4 hydrolase.{25663}
Brand:CaymanSKU:- Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 (Item No. 20110) from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro.{12673,20329} ARM1 is a thiazolamine that inhibits LTB4 synthesis in human neutrophils (IC50 = ~0.5 µM) and conversion of LTA4 to LTB4 by purified LTA4 hydrolase (Ki = 2.3 µM).{25663} ARM1 does not significantly affect the hydrolysis of Pro-Gly-Pro by LTA4 hydrolase.{25663}
Brand:CaymanSKU:- Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 (Item No. 20110) from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro.{12673,20329} ARM1 is a thiazolamine that inhibits LTB4 synthesis in human neutrophils (IC50 = ~0.5 µM) and conversion of LTA4 to LTB4 by purified LTA4 hydrolase (Ki = 2.3 µM).{25663} ARM1 does not significantly affect the hydrolysis of Pro-Gly-Pro by LTA4 hydrolase.{25663}
Brand:CaymanSKU:-
ARN-509 is an antagonist of the androgen receptor (IC50 = 16 nM).{28061} It binds the receptor but does not cause nuclear localization or DNA binding.{28061} ARN-509 is orally bioavailable and, at 30 mg/kg/d, suppresses tumor growth in a mouse model of castration-resistant prostate cancer.{28061} This compound can be used to study androgen signaling in vitro and in vivo and has potential applications in certain types of cancer.{28062}
Brand:CaymanSKU:-Out of stock
ARN-509 is an antagonist of the androgen receptor (IC50 = 16 nM).{28061} It binds the receptor but does not cause nuclear localization or DNA binding.{28061} ARN-509 is orally bioavailable and, at 30 mg/kg/d, suppresses tumor growth in a mouse model of castration-resistant prostate cancer.{28061} This compound can be used to study androgen signaling in vitro and in vivo and has potential applications in certain types of cancer.{28062}
Brand:CaymanSKU:-Out of stock
ARN-509 is an antagonist of the androgen receptor (IC50 = 16 nM).{28061} It binds the receptor but does not cause nuclear localization or DNA binding.{28061} ARN-509 is orally bioavailable and, at 30 mg/kg/d, suppresses tumor growth in a mouse model of castration-resistant prostate cancer.{28061} This compound can be used to study androgen signaling in vitro and in vivo and has potential applications in certain types of cancer.{28062}
Brand:CaymanSKU:-Out of stock
Arachidonoyl ethanolamide (AEA, Item No. 90050), also known as anandamide, is an endogenous ligand of the cannabinoid receptors.{2713} AEA is metabolized by fatty acid amide hydrolase (FAAH) to give arachidonic acid (Item No. 90010) and ethanolamine.{15373} ARN1203 is a fluorinated analog of AEA that serves as a substrate of FAAH (Km = 29 µM).{25931} Fluorinated substrates, like ARN1023, are used in ‘n-fluorine atoms for biochemical screening’ (n-FABS) assays, NMR functional assays that directly measure the conversion of the substrate into product.{25932} ARN1203 is used to perform n-FABS against FAAH to identify novel inhibitors.{25931, 25932,25933}
Brand:CaymanSKU:- Arachidonoyl ethanolamide (AEA, Item No. 90050), also known as anandamide, is an endogenous ligand of the cannabinoid receptors.{2713} AEA is metabolized by fatty acid amide hydrolase (FAAH) to give arachidonic acid (Item No. 90010) and ethanolamine.{15373} ARN1203 is a fluorinated analog of AEA that serves as a substrate of FAAH (Km = 29 µM).{25931} Fluorinated substrates, like ARN1023, are used in ‘n-fluorine atoms for biochemical screening’ (n-FABS) assays, NMR functional assays that directly measure the conversion of the substrate into product.{25932} ARN1203 is used to perform n-FABS against FAAH to identify novel inhibitors.{25931, 25932,25933}
Brand:CaymanSKU:- Arachidonoyl ethanolamide (AEA, Item No. 90050), also known as anandamide, is an endogenous ligand of the cannabinoid receptors.{2713} AEA is metabolized by fatty acid amide hydrolase (FAAH) to give arachidonic acid (Item No. 90010) and ethanolamine.{15373} ARN1203 is a fluorinated analog of AEA that serves as a substrate of FAAH (Km = 29 µM).{25931} Fluorinated substrates, like ARN1023, are used in ‘n-fluorine atoms for biochemical screening’ (n-FABS) assays, NMR functional assays that directly measure the conversion of the substrate into product.{25932} ARN1203 is used to perform n-FABS against FAAH to identify novel inhibitors.{25931, 25932,25933}
Brand:CaymanSKU:- Arachidonoyl ethanolamide (AEA, Item No. 90050), also known as anandamide, is an endogenous ligand of the cannabinoid receptors.{2713} AEA is metabolized by fatty acid amide hydrolase (FAAH) to give arachidonic acid (Item No. 90010) and ethanolamine.{15373} ARN1203 is a fluorinated analog of AEA that serves as a substrate of FAAH (Km = 29 µM).{25931} Fluorinated substrates, like ARN1023, are used in ‘n-fluorine atoms for biochemical screening’ (n-FABS) assays, NMR functional assays that directly measure the conversion of the substrate into product.{25932} ARN1203 is used to perform n-FABS against FAAH to identify novel inhibitors.{25931, 25932,25933}
Brand:CaymanSKU:-
ARN14686 is an activity-based affinity probe for the detection of N-acylethanolamine acid amidase (NAAA) using click chemistry.{36895} It binds covalently to the N-terminal cysteine of catalytically active NAAA to form a thioester adduct. ARN14686 inhibits the hydrolysis of the NAAA substrate PAMCA in HEK293 cells (IC50s = 6 and 13 nM for human and rat recombinant enzymes, respectively) and is selective for NAAA over acid ceramidase (IC50 = 1,200 nM for the rat enzyme). It labels NAAA in HEK293 cells overexpressing human or rat recombinant NAAA and, when used at concentrations of 1 and 10 µM, in rat lung lysosomal fractions in vitro. It also detects NAAA in lung lysosomal fractions following intravenous administration at a dose of 10 mg/kg in rats. ARN14686 (3 mg/kg) has been used to determine that catalytically active NAAA is present in inflamed rat paw in a complete Freund’s adjuvant model of inflammation.{36896}
Brand:CaymanSKU:24261 - 1 mgAvailable on backorder
ARN14686 is an activity-based affinity probe for the detection of N-acylethanolamine acid amidase (NAAA) using click chemistry.{36895} It binds covalently to the N-terminal cysteine of catalytically active NAAA to form a thioester adduct. ARN14686 inhibits the hydrolysis of the NAAA substrate PAMCA in HEK293 cells (IC50s = 6 and 13 nM for human and rat recombinant enzymes, respectively) and is selective for NAAA over acid ceramidase (IC50 = 1,200 nM for the rat enzyme). It labels NAAA in HEK293 cells overexpressing human or rat recombinant NAAA and, when used at concentrations of 1 and 10 µM, in rat lung lysosomal fractions in vitro. It also detects NAAA in lung lysosomal fractions following intravenous administration at a dose of 10 mg/kg in rats. ARN14686 (3 mg/kg) has been used to determine that catalytically active NAAA is present in inflamed rat paw in a complete Freund’s adjuvant model of inflammation.{36896}
Brand:CaymanSKU:24261 - 10 mgAvailable on backorder
ARN14686 is an activity-based affinity probe for the detection of N-acylethanolamine acid amidase (NAAA) using click chemistry.{36895} It binds covalently to the N-terminal cysteine of catalytically active NAAA to form a thioester adduct. ARN14686 inhibits the hydrolysis of the NAAA substrate PAMCA in HEK293 cells (IC50s = 6 and 13 nM for human and rat recombinant enzymes, respectively) and is selective for NAAA over acid ceramidase (IC50 = 1,200 nM for the rat enzyme). It labels NAAA in HEK293 cells overexpressing human or rat recombinant NAAA and, when used at concentrations of 1 and 10 µM, in rat lung lysosomal fractions in vitro. It also detects NAAA in lung lysosomal fractions following intravenous administration at a dose of 10 mg/kg in rats. ARN14686 (3 mg/kg) has been used to determine that catalytically active NAAA is present in inflamed rat paw in a complete Freund’s adjuvant model of inflammation.{36896}
Brand:CaymanSKU:24261 - 25 mgAvailable on backorder
ARN14686 is an activity-based affinity probe for the detection of N-acylethanolamine acid amidase (NAAA) using click chemistry.{36895} It binds covalently to the N-terminal cysteine of catalytically active NAAA to form a thioester adduct. ARN14686 inhibits the hydrolysis of the NAAA substrate PAMCA in HEK293 cells (IC50s = 6 and 13 nM for human and rat recombinant enzymes, respectively) and is selective for NAAA over acid ceramidase (IC50 = 1,200 nM for the rat enzyme). It labels NAAA in HEK293 cells overexpressing human or rat recombinant NAAA and, when used at concentrations of 1 and 10 µM, in rat lung lysosomal fractions in vitro. It also detects NAAA in lung lysosomal fractions following intravenous administration at a dose of 10 mg/kg in rats. ARN14686 (3 mg/kg) has been used to determine that catalytically active NAAA is present in inflamed rat paw in a complete Freund’s adjuvant model of inflammation.{36896}
Brand:CaymanSKU:24261 - 5 mgAvailable on backorder
ARN14974 is a benzoxazolone carboxamide inhibitor of acid ceramidase (IC50 = 79 nM).{27811} It inhibits acid ceramidase activity, reduces levels of sphingosine and dihydroceramide, and increases levels of ceramide in SW403 adenocarcinoma cells and RAW 264.7 murine macrophages when used at concentrations ranging from 0.1 to 20 mM. In vivo, ARN14974 (10 mg/kg, i.v.) reduces acid ceramidase activity in multiple organs, including brain, liver, heart, lungs, and kidney, and increases pulmonary ceramide levels in mice.
Brand:CaymanSKU:-Out of stock
ARN14974 is a benzoxazolone carboxamide inhibitor of acid ceramidase (IC50 = 79 nM).{27811} It inhibits acid ceramidase activity, reduces levels of sphingosine and dihydroceramide, and increases levels of ceramide in SW403 adenocarcinoma cells and RAW 264.7 murine macrophages when used at concentrations ranging from 0.1 to 20 mM. In vivo, ARN14974 (10 mg/kg, i.v.) reduces acid ceramidase activity in multiple organs, including brain, liver, heart, lungs, and kidney, and increases pulmonary ceramide levels in mice.
Brand:CaymanSKU:-Out of stock
ARN14974 is a benzoxazolone carboxamide inhibitor of acid ceramidase (IC50 = 79 nM).{27811} It inhibits acid ceramidase activity, reduces levels of sphingosine and dihydroceramide, and increases levels of ceramide in SW403 adenocarcinoma cells and RAW 264.7 murine macrophages when used at concentrations ranging from 0.1 to 20 mM. In vivo, ARN14974 (10 mg/kg, i.v.) reduces acid ceramidase activity in multiple organs, including brain, liver, heart, lungs, and kidney, and increases pulmonary ceramide levels in mice.
Brand:CaymanSKU:-Out of stock
ARN14974 is a benzoxazolone carboxamide inhibitor of acid ceramidase (IC50 = 79 nM).{27811} It inhibits acid ceramidase activity, reduces levels of sphingosine and dihydroceramide, and increases levels of ceramide in SW403 adenocarcinoma cells and RAW 264.7 murine macrophages when used at concentrations ranging from 0.1 to 20 mM. In vivo, ARN14974 (10 mg/kg, i.v.) reduces acid ceramidase activity in multiple organs, including brain, liver, heart, lungs, and kidney, and increases pulmonary ceramide levels in mice.
Brand:CaymanSKU:-Out of stock
ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme).{40582} It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide (Item No. 24369) and C16 ceramide (Item No. 10681) in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 µM, respectively).
Brand:CaymanSKU:24284 - 1 mgAvailable on backorder
ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme).{40582} It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide (Item No. 24369) and C16 ceramide (Item No. 10681) in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 µM, respectively).
Brand:CaymanSKU:24284 - 10 mgAvailable on backorder
ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme).{40582} It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide (Item No. 24369) and C16 ceramide (Item No. 10681) in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 µM, respectively).
Brand:CaymanSKU:24284 - 25 mgAvailable on backorder
ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme).{40582} It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide (Item No. 24369) and C16 ceramide (Item No. 10681) in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 µM, respectively).
Brand:CaymanSKU:24284 - 5 mgAvailable on backorder
ARN19874 is an inhibitor of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD; IC50 = 33.7 µM).{40567} It is selective for NAPD-PLD over carbonic anhydrase II, neutral endopeptidase, and angiotensin-converting enzyme (ACE) up to 50 µM. ARN19874 (50 µM) increases the levels of certain NAPE substrates and decreases the endogenous levels of stearoyl ethanolamide (Item No. 90245), but not oleoyl ethanolamide (Item No. 90265) or palmitoyl ethanolamide (Item No. 90350), in HEK293 cells.
Brand:CaymanSKU:24283 - 1 mgAvailable on backorder
ARN19874 is an inhibitor of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD; IC50 = 33.7 µM).{40567} It is selective for NAPD-PLD over carbonic anhydrase II, neutral endopeptidase, and angiotensin-converting enzyme (ACE) up to 50 µM. ARN19874 (50 µM) increases the levels of certain NAPE substrates and decreases the endogenous levels of stearoyl ethanolamide (Item No. 90245), but not oleoyl ethanolamide (Item No. 90265) or palmitoyl ethanolamide (Item No. 90350), in HEK293 cells.
Brand:CaymanSKU:24283 - 10 mgAvailable on backorder
ARN19874 is an inhibitor of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD; IC50 = 33.7 µM).{40567} It is selective for NAPD-PLD over carbonic anhydrase II, neutral endopeptidase, and angiotensin-converting enzyme (ACE) up to 50 µM. ARN19874 (50 µM) increases the levels of certain NAPE substrates and decreases the endogenous levels of stearoyl ethanolamide (Item No. 90245), but not oleoyl ethanolamide (Item No. 90265) or palmitoyl ethanolamide (Item No. 90350), in HEK293 cells.
Brand:CaymanSKU:24283 - 5 mgAvailable on backorder