Cayman
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Amino tadalafil is an analog of tadalafil (Item No. 14024), a potent inhibitor of phosphodiesterase 5 with applications in several conditions, including erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.{32875} Amino tadalafil has been detected as an illegal adulterant in a dietary supplement marketed for “tonic effect.”{32874}
Brand:CaymanSKU:20876 -Out of stock
Amino tadalafil is an analog of tadalafil (Item No. 14024), a potent inhibitor of phosphodiesterase 5 with applications in several conditions, including erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.{32875} Amino tadalafil has been detected as an illegal adulterant in a dietary supplement marketed for “tonic effect.”{32874}
Brand:CaymanSKU:20876 -Out of stock
Aminoacetone is a threonine and glycine catabolite that can be converted to methylglyoxal by amine oxidases.{28509} It has been identified as one of several endogenous sources of methylglyoxal found in the plasma of diabetes patients.{28508} As a pro-oxidant, 0.10-5 mM aminoacetone can induce cell death in RINm5f pancreatic β-cells.{28508} Aminoacetone is used as a growth substrate for Pseudomonas.{28507}
Brand:CaymanSKU:-Available on backorder
Aminoacetone is a threonine and glycine catabolite that can be converted to methylglyoxal by amine oxidases.{28509} It has been identified as one of several endogenous sources of methylglyoxal found in the plasma of diabetes patients.{28508} As a pro-oxidant, 0.10-5 mM aminoacetone can induce cell death in RINm5f pancreatic β-cells.{28508} Aminoacetone is used as a growth substrate for Pseudomonas.{28507}
Brand:CaymanSKU:-Available on backorder
Aminoacetone is a threonine and glycine catabolite that can be converted to methylglyoxal by amine oxidases.{28509} It has been identified as one of several endogenous sources of methylglyoxal found in the plasma of diabetes patients.{28508} As a pro-oxidant, 0.10-5 mM aminoacetone can induce cell death in RINm5f pancreatic β-cells.{28508} Aminoacetone is used as a growth substrate for Pseudomonas.{28507}
Brand:CaymanSKU:-Available on backorder
Ethylene, an important plant regulator, is synthesized from S-adenosyl-L-methionine by the sequential action of 1-amino-cyclopropane-carboxylate (ACC) synthases (ACSs) and ACC oxidases (ACOs). Aminoethoxyvinyl glycine is an inhibitor of ethylene biosynthesis that, at 1 µM, blocks the activity of both ACSs and ACOs.{25600} Through this action, it reduces ethylene-mediated changes in plant growth and development.{25602,25599,25598} Aminoethoxyvinyl glycine also inhibits cystathionine γ-lyase (Ki = 10.5 μM) with slow- and tight-binding characteristics.{17812}
Brand:CaymanSKU:- Ethylene, an important plant regulator, is synthesized from S-adenosyl-L-methionine by the sequential action of 1-amino-cyclopropane-carboxylate (ACC) synthases (ACSs) and ACC oxidases (ACOs). Aminoethoxyvinyl glycine is an inhibitor of ethylene biosynthesis that, at 1 µM, blocks the activity of both ACSs and ACOs.{25600} Through this action, it reduces ethylene-mediated changes in plant growth and development.{25602,25599,25598} Aminoethoxyvinyl glycine also inhibits cystathionine γ-lyase (Ki = 10.5 μM) with slow- and tight-binding characteristics.{17812}
Brand:CaymanSKU:- Ethylene, an important plant regulator, is synthesized from S-adenosyl-L-methionine by the sequential action of 1-amino-cyclopropane-carboxylate (ACC) synthases (ACSs) and ACC oxidases (ACOs). Aminoethoxyvinyl glycine is an inhibitor of ethylene biosynthesis that, at 1 µM, blocks the activity of both ACSs and ACOs.{25600} Through this action, it reduces ethylene-mediated changes in plant growth and development.{25602,25599,25598} Aminoethoxyvinyl glycine also inhibits cystathionine γ-lyase (Ki = 10.5 μM) with slow- and tight-binding characteristics.{17812}
Brand:CaymanSKU:- Ethylene, an important plant regulator, is synthesized from S-adenosyl-L-methionine by the sequential action of 1-amino-cyclopropane-carboxylate (ACC) synthases (ACSs) and ACC oxidases (ACOs). Aminoethoxyvinyl glycine is an inhibitor of ethylene biosynthesis that, at 1 µM, blocks the activity of both ACSs and ACOs.{25600} Through this action, it reduces ethylene-mediated changes in plant growth and development.{25602,25599,25598} Aminoethoxyvinyl glycine also inhibits cystathionine γ-lyase (Ki = 10.5 μM) with slow- and tight-binding characteristics.{17812}
Brand:CaymanSKU:-
Aminoglutethimide is an aromatase inhibitor (IC50 = 7.5 µM).{27484} Aromatase inhibitors, including aminoglutethimide, inhibit estrogen synthesis via aromatase, suppressing estrogen levels in post-menopausal women. Formulations containing aromatase inhibitors have been used to treat estrogen receptor-positive breast cancer in post-menopausal women.{22657,11203}
Brand:CaymanSKU:20947 -Out of stock
Aminoglutethimide is an aromatase inhibitor (IC50 = 7.5 µM).{27484} Aromatase inhibitors, including aminoglutethimide, inhibit estrogen synthesis via aromatase, suppressing estrogen levels in post-menopausal women. Formulations containing aromatase inhibitors have been used to treat estrogen receptor-positive breast cancer in post-menopausal women.{22657,11203}
Brand:CaymanSKU:20947 -Out of stock
Aminoglutethimide is an aromatase inhibitor (IC50 = 7.5 µM).{27484} Aromatase inhibitors, including aminoglutethimide, inhibit estrogen synthesis via aromatase, suppressing estrogen levels in post-menopausal women. Formulations containing aromatase inhibitors have been used to treat estrogen receptor-positive breast cancer in post-menopausal women.{22657,11203}
Brand:CaymanSKU:20947 -Out of stock
Aminoguanidine is equipotent to L-NMMA and L-NNA as an inhibitor of iNOS.{1856,1859} The IC50 values for inhibition of mouse iNOS and rat nNOS are 5.4 and 160 µM, respectively.{1859} Aminoguanidine also inhibits induction of iNOS protein expression by endotoxin in rat macrophages.{3447}
Brand:CaymanSKU:81530 - 10 gAvailable on backorder
Aminoguanidine is equipotent to L-NMMA and L-NNA as an inhibitor of iNOS.{1856,1859} The IC50 values for inhibition of mouse iNOS and rat nNOS are 5.4 and 160 µM, respectively.{1859} Aminoguanidine also inhibits induction of iNOS protein expression by endotoxin in rat macrophages.{3447}
Brand:CaymanSKU:81530 - 100 gAvailable on backorder
Aminoguanidine is equipotent to L-NMMA and L-NNA as an inhibitor of iNOS.{1856,1859} The IC50 values for inhibition of mouse iNOS and rat nNOS are 5.4 and 160 µM, respectively.{1859} Aminoguanidine also inhibits induction of iNOS protein expression by endotoxin in rat macrophages.{3447}
Brand:CaymanSKU:81530 - 25 gAvailable on backorder
Aminoguanidine is equipotent to L-NMMA and L-NNA as an inhibitor of iNOS.{1856,1859} The IC50 values for inhibition of mouse iNOS and rat nNOS are 5.4 and 160 µM, respectively.{1859} Aminoguanidine also inhibits induction of iNOS protein expression by endotoxin in rat macrophages.{3447}
Brand:CaymanSKU:81530 - 50 gAvailable on backorder
Aminooxyacetic acid is a GABA transaminase (GABA-T) inhibitor (Ki = 9.16 μM) that induces GABA accumulation in the brain.{51157} It also inhibits cystathionine β synthase (CBS) and cystathionine γ lyase (CSE; IC50s = 8.5 and 1.1 μM, respectively).{51158} Aminooxyacetic acid (100 mg/kg) decreases GABA-T activity, without affecting glutamic acid decarboxylase (GAD) activity, and increases GABA levels in all regions of rat brain.{51159} It also decreases GABA-T activity and increases GABA in mouse brain when administered at a dose of 13 mg/kg.{51160} Aminooxyacetic acid inhibits 3-mercaptopropionic acid-, strychnine-, and pentetrazole-induced seizures in mice (ED50s = 53, 130, and 85 mg/kg, respectively), however, it exhibits neurotoxicity in the chimney test (ED50 = 62 mg/kg) and is lethal (LD50 = 105 mg/kg) to mice.
Brand:CaymanSKU:28298 - 1 gAvailable on backorder
Aminooxyacetic acid is a GABA transaminase (GABA-T) inhibitor (Ki = 9.16 μM) that induces GABA accumulation in the brain.{51157} It also inhibits cystathionine β synthase (CBS) and cystathionine γ lyase (CSE; IC50s = 8.5 and 1.1 μM, respectively).{51158} Aminooxyacetic acid (100 mg/kg) decreases GABA-T activity, without affecting glutamic acid decarboxylase (GAD) activity, and increases GABA levels in all regions of rat brain.{51159} It also decreases GABA-T activity and increases GABA in mouse brain when administered at a dose of 13 mg/kg.{51160} Aminooxyacetic acid inhibits 3-mercaptopropionic acid-, strychnine-, and pentetrazole-induced seizures in mice (ED50s = 53, 130, and 85 mg/kg, respectively), however, it exhibits neurotoxicity in the chimney test (ED50 = 62 mg/kg) and is lethal (LD50 = 105 mg/kg) to mice.
Brand:CaymanSKU:28298 - 100 mgAvailable on backorder
Aminooxyacetic acid is a GABA transaminase (GABA-T) inhibitor (Ki = 9.16 μM) that induces GABA accumulation in the brain.{51157} It also inhibits cystathionine β synthase (CBS) and cystathionine γ lyase (CSE; IC50s = 8.5 and 1.1 μM, respectively).{51158} Aminooxyacetic acid (100 mg/kg) decreases GABA-T activity, without affecting glutamic acid decarboxylase (GAD) activity, and increases GABA levels in all regions of rat brain.{51159} It also decreases GABA-T activity and increases GABA in mouse brain when administered at a dose of 13 mg/kg.{51160} Aminooxyacetic acid inhibits 3-mercaptopropionic acid-, strychnine-, and pentetrazole-induced seizures in mice (ED50s = 53, 130, and 85 mg/kg, respectively), however, it exhibits neurotoxicity in the chimney test (ED50 = 62 mg/kg) and is lethal (LD50 = 105 mg/kg) to mice.
Brand:CaymanSKU:28298 - 250 mgAvailable on backorder
Aminooxyacetic acid is a GABA transaminase (GABA-T) inhibitor (Ki = 9.16 μM) that induces GABA accumulation in the brain.{51157} It also inhibits cystathionine β synthase (CBS) and cystathionine γ lyase (CSE; IC50s = 8.5 and 1.1 μM, respectively).{51158} Aminooxyacetic acid (100 mg/kg) decreases GABA-T activity, without affecting glutamic acid decarboxylase (GAD) activity, and increases GABA levels in all regions of rat brain.{51159} It also decreases GABA-T activity and increases GABA in mouse brain when administered at a dose of 13 mg/kg.{51160} Aminooxyacetic acid inhibits 3-mercaptopropionic acid-, strychnine-, and pentetrazole-induced seizures in mice (ED50s = 53, 130, and 85 mg/kg, respectively), however, it exhibits neurotoxicity in the chimney test (ED50 = 62 mg/kg) and is lethal (LD50 = 105 mg/kg) to mice.
Brand:CaymanSKU:28298 - 500 mgAvailable on backorder
Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM).{39592} It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM.
Brand:CaymanSKU:24307 - 1 mgAvailable on backorder
Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM).{39592} It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM.
Brand:CaymanSKU:24307 - 10 mgAvailable on backorder
Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM).{39592} It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM.
Brand:CaymanSKU:24307 - 5 mgAvailable on backorder
Aminophenazone is an analgesic and anti-inflammatory compound.{45093} It decreases acetic acid-induced writhing in mice (ED50 = 46 mg/kg, s.c.) and reduces inflammation in a rat model of paw edema when administered at a dose of 48.2 mg/kg. Formulations containing aminophenazone have previously been used in the treatment of pain.
Brand:CaymanSKU:- Aminophenazone is an analgesic and anti-inflammatory compound.{45093} It decreases acetic acid-induced writhing in mice (ED50 = 46 mg/kg, s.c.) and reduces inflammation in a rat model of paw edema when administered at a dose of 48.2 mg/kg. Formulations containing aminophenazone have previously been used in the treatment of pain.
Brand:CaymanSKU:- Aminophenazone is an analgesic and anti-inflammatory compound.{45093} It decreases acetic acid-induced writhing in mice (ED50 = 46 mg/kg, s.c.) and reduces inflammation in a rat model of paw edema when administered at a dose of 48.2 mg/kg. Formulations containing aminophenazone have previously been used in the treatment of pain.
Brand:CaymanSKU:- Aminophenazone is an analgesic and anti-inflammatory compound.{45093} It decreases acetic acid-induced writhing in mice (ED50 = 46 mg/kg, s.c.) and reduces inflammation in a rat model of paw edema when administered at a dose of 48.2 mg/kg. Formulations containing aminophenazone have previously been used in the treatment of pain.
Brand:CaymanSKU:-
Aminophylline is a competitive and non-selective phosphodiesterase inhibitor (IC50 = 120 µM) and adenosine receptor antagonist.{37006,37010} It is a complex of theophylline and ethylenediamine that has in vivo bronchodilator and vasodilator effects.{37006,37007} Aminophylline suppresses maternal separation- and acetic acid administration-induced visceral hypersensitivity to colorectal distension in a rat model of irritable bowel syndrome with diarrhea (IBS-D).{37008} Aminophylline also provides renoprotection against murine renal ischemia-reperfusion injury.{37009}
Brand:CaymanSKU:22235 -Out of stock
Aminophylline is a competitive and non-selective phosphodiesterase inhibitor (IC50 = 120 µM) and adenosine receptor antagonist.{37006,37010} It is a complex of theophylline and ethylenediamine that has in vivo bronchodilator and vasodilator effects.{37006,37007} Aminophylline suppresses maternal separation- and acetic acid administration-induced visceral hypersensitivity to colorectal distension in a rat model of irritable bowel syndrome with diarrhea (IBS-D).{37008} Aminophylline also provides renoprotection against murine renal ischemia-reperfusion injury.{37009}
Brand:CaymanSKU:22235 -Out of stock
Aminophylline is a competitive and non-selective phosphodiesterase inhibitor (IC50 = 120 µM) and adenosine receptor antagonist.{37006,37010} It is a complex of theophylline and ethylenediamine that has in vivo bronchodilator and vasodilator effects.{37006,37007} Aminophylline suppresses maternal separation- and acetic acid administration-induced visceral hypersensitivity to colorectal distension in a rat model of irritable bowel syndrome with diarrhea (IBS-D).{37008} Aminophylline also provides renoprotection against murine renal ischemia-reperfusion injury.{37009}
Brand:CaymanSKU:22235 -Out of stock
Aminophylline is a competitive and non-selective phosphodiesterase inhibitor (IC50 = 120 µM) and adenosine receptor antagonist.{37006,37010} It is a complex of theophylline and ethylenediamine that has in vivo bronchodilator and vasodilator effects.{37006,37007} Aminophylline suppresses maternal separation- and acetic acid administration-induced visceral hypersensitivity to colorectal distension in a rat model of irritable bowel syndrome with diarrhea (IBS-D).{37008} Aminophylline also provides renoprotection against murine renal ischemia-reperfusion injury.{37009}
Brand:CaymanSKU:22235 -Out of stock
Aminopterin is a synthetic folic acid (Item No. 20515) derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase, which is a cofactor for nucleic acid synthesis. Aminopterin has anticancer and immunosuppressive properties. Formulations containing it have been used for pediatric leukemia though methotrexate (Item No. 13960) is now more commonly used due to a more favorable therapeutic index.{34057,34058,34056} Aminopterin is a component of the widely used HAT (hypoxanthine-aminopterin-thymidine) medium to select cells for mammalian cell culture.{34059}
Brand:CaymanSKU:21802 -Out of stock
Aminopterin is a synthetic folic acid (Item No. 20515) derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase, which is a cofactor for nucleic acid synthesis. Aminopterin has anticancer and immunosuppressive properties. Formulations containing it have been used for pediatric leukemia though methotrexate (Item No. 13960) is now more commonly used due to a more favorable therapeutic index.{34057,34058,34056} Aminopterin is a component of the widely used HAT (hypoxanthine-aminopterin-thymidine) medium to select cells for mammalian cell culture.{34059}
Brand:CaymanSKU:21802 -Out of stock
Aminopterin is a synthetic folic acid (Item No. 20515) derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase, which is a cofactor for nucleic acid synthesis. Aminopterin has anticancer and immunosuppressive properties. Formulations containing it have been used for pediatric leukemia though methotrexate (Item No. 13960) is now more commonly used due to a more favorable therapeutic index.{34057,34058,34056} Aminopterin is a component of the widely used HAT (hypoxanthine-aminopterin-thymidine) medium to select cells for mammalian cell culture.{34059}
Brand:CaymanSKU:21802 -Out of stock
Aminopurvalanol A is a selective, cell-permeable, and competitive cyclin-dependent kinase (CDK) inhibitor that potently inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p35 (IC50s = 33, 33, 28, and 20 nM, respectively).{39089} It is over 90-fold selective for CDKs over ERK1, ERK2, PKC-δ, protein kinase A (PKA), casein kinase 1, insulin receptor tyrosine kinase (IC50s = 3.0-36 μM), and over 3,000-fold selective over a range of other kinases (IC50s > 100 μM). In antiproliferative assays in vitro, aminopurvalanol A inhibits growth of ovarian (IGROV1), leukemic (SR), lung (NCI-H522), and colonic (KM12) cells (GI50s = 470, 420, 1,000, and 30 nM, respectively). Aminopurvalanol A also inhibits mitotic division and preferentially arrests cells in the G2/M phase via Cdk1/cyclin B{39090,39091}
Brand:CaymanSKU:21424 -Out of stock
Aminopurvalanol A is a selective, cell-permeable, and competitive cyclin-dependent kinase (CDK) inhibitor that potently inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p35 (IC50s = 33, 33, 28, and 20 nM, respectively).{39089} It is over 90-fold selective for CDKs over ERK1, ERK2, PKC-δ, protein kinase A (PKA), casein kinase 1, insulin receptor tyrosine kinase (IC50s = 3.0-36 μM), and over 3,000-fold selective over a range of other kinases (IC50s > 100 μM). In antiproliferative assays in vitro, aminopurvalanol A inhibits growth of ovarian (IGROV1), leukemic (SR), lung (NCI-H522), and colonic (KM12) cells (GI50s = 470, 420, 1,000, and 30 nM, respectively). Aminopurvalanol A also inhibits mitotic division and preferentially arrests cells in the G2/M phase via Cdk1/cyclin B{39090,39091}
Brand:CaymanSKU:21424 -Out of stock
Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents.{22478} It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM.{24593} In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ8Δ7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC50s = 0.6, 0.65 µM, respectively).{24575,24578} It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.{24577}
Brand:CaymanSKU:- Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents.{22478} It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM.{24593} In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ8Δ7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC50s = 0.6, 0.65 µM, respectively).{24575,24578} It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.{24577}
Brand:CaymanSKU:- Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents.{22478} It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM.{24593} In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ8Δ7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC50s = 0.6, 0.65 µM, respectively).{24575,24578} It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.{24577}
Brand:CaymanSKU:- Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents.{22478} It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM.{24593} In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ8Δ7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC50s = 0.6, 0.65 µM, respectively).{24575,24578} It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.{24577}
Brand:CaymanSKU:-
Amiodarone-d4 is intended for use as an internal standard for the quantification of amiodarone (Item No. 15213) by GC- or LC-MS. Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents.{22478} It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM.{24593} In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ8Δ7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC50s = 0.6 and 0.65 µM, respectively).{24575,24578} It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.{24577}
Brand:CaymanSKU:10010668 - 1 mgAvailable on backorder
Amiodarone-d4 is intended for use as an internal standard for the quantification of amiodarone (Item No. 15213) by GC- or LC-MS. Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents.{22478} It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM.{24593} In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ8Δ7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC50s = 0.6 and 0.65 µM, respectively).{24575,24578} It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.{24577}
Brand:CaymanSKU:10010668 - 5 mgAvailable on backorder
Amiprofos-methyl (APM) is a phosphoric amide herbicide.{38408} It reversibly decreases H. vulgare root and shoot length and inhibits in vitro polymerization of Rosa tubulin induced by paclitaxel (Item No. 10461) in a dose-dependent manner.{38408,38409} APM completely inhibits tubulin polymerization in Hemanthus endosperm cells at a concentration of 0.1 μM.{38408} The antitubulin effects of APM are specific to plants as it has no effect on bovine brain tubulin polymerization at concentrations up to 100 μM. APM inhibits calcium accumulation in corn mitochondria (ID50 = 140 nM) and induces a 3-fold increase in the rate of calcium efflux from rat liver mitochondria at a concentration of 100 nM.{38410} APM inhibits the growth of P. falciparum (IC50 = 3.5 μM) and completely inhibits microtubule polymerization in P. falciparum trophozoites at a concentration of 20 μM.{38411}
Brand:CaymanSKU:23379 - 10 mgAvailable on backorder
Amiprofos-methyl (APM) is a phosphoric amide herbicide.{38408} It reversibly decreases H. vulgare root and shoot length and inhibits in vitro polymerization of Rosa tubulin induced by paclitaxel (Item No. 10461) in a dose-dependent manner.{38408,38409} APM completely inhibits tubulin polymerization in Hemanthus endosperm cells at a concentration of 0.1 μM.{38408} The antitubulin effects of APM are specific to plants as it has no effect on bovine brain tubulin polymerization at concentrations up to 100 μM. APM inhibits calcium accumulation in corn mitochondria (ID50 = 140 nM) and induces a 3-fold increase in the rate of calcium efflux from rat liver mitochondria at a concentration of 100 nM.{38410} APM inhibits the growth of P. falciparum (IC50 = 3.5 μM) and completely inhibits microtubule polymerization in P. falciparum trophozoites at a concentration of 20 μM.{38411}
Brand:CaymanSKU:23379 - 100 mgAvailable on backorder
Amiprofos-methyl (APM) is a phosphoric amide herbicide.{38408} It reversibly decreases H. vulgare root and shoot length and inhibits in vitro polymerization of Rosa tubulin induced by paclitaxel (Item No. 10461) in a dose-dependent manner.{38408,38409} APM completely inhibits tubulin polymerization in Hemanthus endosperm cells at a concentration of 0.1 μM.{38408} The antitubulin effects of APM are specific to plants as it has no effect on bovine brain tubulin polymerization at concentrations up to 100 μM. APM inhibits calcium accumulation in corn mitochondria (ID50 = 140 nM) and induces a 3-fold increase in the rate of calcium efflux from rat liver mitochondria at a concentration of 100 nM.{38410} APM inhibits the growth of P. falciparum (IC50 = 3.5 μM) and completely inhibits microtubule polymerization in P. falciparum trophozoites at a concentration of 20 μM.{38411}
Brand:CaymanSKU:23379 - 5 mgAvailable on backorder
Amiprofos-methyl (APM) is a phosphoric amide herbicide.{38408} It reversibly decreases H. vulgare root and shoot length and inhibits in vitro polymerization of Rosa tubulin induced by paclitaxel (Item No. 10461) in a dose-dependent manner.{38408,38409} APM completely inhibits tubulin polymerization in Hemanthus endosperm cells at a concentration of 0.1 μM.{38408} The antitubulin effects of APM are specific to plants as it has no effect on bovine brain tubulin polymerization at concentrations up to 100 μM. APM inhibits calcium accumulation in corn mitochondria (ID50 = 140 nM) and induces a 3-fold increase in the rate of calcium efflux from rat liver mitochondria at a concentration of 100 nM.{38410} APM inhibits the growth of P. falciparum (IC50 = 3.5 μM) and completely inhibits microtubule polymerization in P. falciparum trophozoites at a concentration of 20 μM.{38411}
Brand:CaymanSKU:23379 - 50 mgAvailable on backorder
Amiselimod is a prodrug that is converted to (S)-amiselimod phosphate by sphingosine kinases.{33207} Amiselimod phosphate is a highly selective S1P1 receptor antagonist (EC50 = 74 pM) that is without activity at S1P3 receptors.{33207} It is approximately five-fold weaker as an activator of G protein-coupled inwardly rectifying K+ (GIRK) channels than fingolimod phosphate.{33207} Amiselimod is orally bioavailable and has minimal cardiac effects when tested clinically.{33207}
Brand:CaymanSKU:20970 -Out of stock
Amiselimod is a prodrug that is converted to (S)-amiselimod phosphate by sphingosine kinases.{33207} Amiselimod phosphate is a highly selective S1P1 receptor antagonist (EC50 = 74 pM) that is without activity at S1P3 receptors.{33207} It is approximately five-fold weaker as an activator of G protein-coupled inwardly rectifying K+ (GIRK) channels than fingolimod phosphate.{33207} Amiselimod is orally bioavailable and has minimal cardiac effects when tested clinically.{33207}
Brand:CaymanSKU:20970 -Out of stock
Amiselimod is a prodrug that is converted to (S)-amiselimod phosphate by sphingosine kinases.{33207} Amiselimod phosphate is a highly selective S1P1 receptor antagonist (EC50 = 74 pM) that is without activity at S1P3 receptors.{33207} It is approximately five-fold weaker as an activator of G protein-coupled inwardly rectifying K+ (GIRK) channels than fingolimod phosphate.{33207} Amiselimod is orally bioavailable and has minimal cardiac effects when tested clinically.{33207}
Brand:CaymanSKU:20970 -Out of stock
Amiselimod is a prodrug that is converted to (S)-amiselimod phosphate by sphingosine kinases.{33207} Amiselimod phosphate is a highly selective S1P1 receptor antagonist (EC50 = 74 pM) that is without activity at S1P3 receptors.{33207} It is approximately five-fold weaker as an activator of G protein-coupled inwardly rectifying K+ (GIRK) channels than fingolimod phosphate.{33207} Amiselimod is orally bioavailable and has minimal cardiac effects when tested clinically.{33207}
Brand:CaymanSKU:20970 -Out of stock
Amisulpride is a dopamine D2 and D3 receptor antagonist (Kis = 3 and 3.5 nM, respectively).{23395} It is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT2B, 5-HT7, and 5-HT7A (Kis = 13, 11.5, and 135.5 nM, respectively). It is selective for these receptors over a panel of 39 additional receptors, ion channels, and transporters (Kis = >1,000 nM for all). Amisulpride increases 7-OH-DPAT-induced decreases in dopamine and acetylcholine release in electrically stimulated rat striatal slices (EC50s = 2.2 and 1.2 nM, respectively).{23392} It increases the levels of dopamine and the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in rat striatum and nucleus accumbens when administered intraperitoneally at a dose of 10 mg/kg. Amisulpride decreases immobility time in the forced swim test in rats, as well as increases stress-induced decreases in sucrose consumption in a rat model of depression induced by chronic mild stress.{48918}
Brand:CaymanSKU:- Amisulpride is a dopamine D2 and D3 receptor antagonist (Kis = 3 and 3.5 nM, respectively).{23395} It is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT2B, 5-HT7, and 5-HT7A (Kis = 13, 11.5, and 135.5 nM, respectively). It is selective for these receptors over a panel of 39 additional receptors, ion channels, and transporters (Kis = >1,000 nM for all). Amisulpride increases 7-OH-DPAT-induced decreases in dopamine and acetylcholine release in electrically stimulated rat striatal slices (EC50s = 2.2 and 1.2 nM, respectively).{23392} It increases the levels of dopamine and the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in rat striatum and nucleus accumbens when administered intraperitoneally at a dose of 10 mg/kg. Amisulpride decreases immobility time in the forced swim test in rats, as well as increases stress-induced decreases in sucrose consumption in a rat model of depression induced by chronic mild stress.{48918}
Brand:CaymanSKU:- Amisulpride is a dopamine D2 and D3 receptor antagonist (Kis = 3 and 3.5 nM, respectively).{23395} It is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT2B, 5-HT7, and 5-HT7A (Kis = 13, 11.5, and 135.5 nM, respectively). It is selective for these receptors over a panel of 39 additional receptors, ion channels, and transporters (Kis = >1,000 nM for all). Amisulpride increases 7-OH-DPAT-induced decreases in dopamine and acetylcholine release in electrically stimulated rat striatal slices (EC50s = 2.2 and 1.2 nM, respectively).{23392} It increases the levels of dopamine and the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in rat striatum and nucleus accumbens when administered intraperitoneally at a dose of 10 mg/kg. Amisulpride decreases immobility time in the forced swim test in rats, as well as increases stress-induced decreases in sucrose consumption in a rat model of depression induced by chronic mild stress.{48918}
Brand:CaymanSKU:- Amisulpride is a dopamine D2 and D3 receptor antagonist (Kis = 3 and 3.5 nM, respectively).{23395} It is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT2B, 5-HT7, and 5-HT7A (Kis = 13, 11.5, and 135.5 nM, respectively). It is selective for these receptors over a panel of 39 additional receptors, ion channels, and transporters (Kis = >1,000 nM for all). Amisulpride increases 7-OH-DPAT-induced decreases in dopamine and acetylcholine release in electrically stimulated rat striatal slices (EC50s = 2.2 and 1.2 nM, respectively).{23392} It increases the levels of dopamine and the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in rat striatum and nucleus accumbens when administered intraperitoneally at a dose of 10 mg/kg. Amisulpride decreases immobility time in the forced swim test in rats, as well as increases stress-induced decreases in sucrose consumption in a rat model of depression induced by chronic mild stress.{48918}
Brand:CaymanSKU:-
Amisulpride-d5 is intended for use as an internal standard for the quantification of amisulpride (Item No. 14619) by GC- or LC-MS. Amisulpride is a dopamine D2 and D3 receptor antagonist (Kis = 3 and 3.5 nM, respectively).{23395} It is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT2B, 5-HT7, and 5-HT7A (Kis = 13, 11.5, and 135.5 nM, respectively). It is selective for these receptors over a panel of 39 additional receptors, ion channels, and transporters (Kis = >1,000 nM for all). Amisulpride increases 7-OH-DPAT-induced decreases in dopamine and acetylcholine release in electrically stimulated rat striatal slices (EC50s = 2.2 and 1.2 nM, respectively).{23392} It increases the levels of dopamine and the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in rat striatum and nucleus accumbens when administered intraperitoneally at a dose of 10 mg/kg. Amisulpride decreases immobility time in the forced swim test in rats, as well as reduces stress-induced decreases in sucrose consumption in a rat model of depression induced by chronic mild stress.{48918}
Brand:CaymanSKU:30075 - 1 mgAvailable on backorder
Amitraz is a formamidine acaricide.{52328} It induces mortality and reduces fecundity in adult R. annulatus when used at a concentration of 300 ppm. It is lethal to adult H. bipinosa (LC50 = 181 ppm). Amitraz (100 µM) reduces viability of primary rat hippocampal cells.{52329} In vivo, amitraz (170 mg/kg) increases malondialdehyde (MDA) and nitric oxide (NO) levels and decreases superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) activities in rat liver, kidney, brain, spleen, and testis.{52330} Dietary administration of amitraz reduces larval weight and larval and pupal survival in honey bee (A. mellifera) populations.{52331}
Brand:CaymanSKU:28852 - 1 gAvailable on backorder
Amitraz is a formamidine acaricide.{52328} It induces mortality and reduces fecundity in adult R. annulatus when used at a concentration of 300 ppm. It is lethal to adult H. bipinosa (LC50 = 181 ppm). Amitraz (100 µM) reduces viability of primary rat hippocampal cells.{52329} In vivo, amitraz (170 mg/kg) increases malondialdehyde (MDA) and nitric oxide (NO) levels and decreases superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) activities in rat liver, kidney, brain, spleen, and testis.{52330} Dietary administration of amitraz reduces larval weight and larval and pupal survival in honey bee (A. mellifera) populations.{52331}
Brand:CaymanSKU:28852 - 250 mgAvailable on backorder
Amitraz is a formamidine acaricide.{52328} It induces mortality and reduces fecundity in adult R. annulatus when used at a concentration of 300 ppm. It is lethal to adult H. bipinosa (LC50 = 181 ppm). Amitraz (100 µM) reduces viability of primary rat hippocampal cells.{52329} In vivo, amitraz (170 mg/kg) increases malondialdehyde (MDA) and nitric oxide (NO) levels and decreases superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) activities in rat liver, kidney, brain, spleen, and testis.{52330} Dietary administration of amitraz reduces larval weight and larval and pupal survival in honey bee (A. mellifera) populations.{52331}
Brand:CaymanSKU:28852 - 5 gAvailable on backorder
Amitraz is a formamidine acaricide.{52328} It induces mortality and reduces fecundity in adult R. annulatus when used at a concentration of 300 ppm. It is lethal to adult H. bipinosa (LC50 = 181 ppm). Amitraz (100 µM) reduces viability of primary rat hippocampal cells.{52329} In vivo, amitraz (170 mg/kg) increases malondialdehyde (MDA) and nitric oxide (NO) levels and decreases superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) activities in rat liver, kidney, brain, spleen, and testis.{52330} Dietary administration of amitraz reduces larval weight and larval and pupal survival in honey bee (A. mellifera) populations.{52331}
Brand:CaymanSKU:28852 - 500 mgAvailable on backorder
Amitriptyline is a first generation tricyclic antidepressant that binds to the serotonin and norepinephrine transporters (Kds = 4.3 and 35 nM, respectively).{25873,22877} It is an antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (Ki =20 nM) as well as histamine H1, muscarinic acetylcholine, and α1-adrenergic receptors (Kis = 1.1, 18, and 27 nM, respectively).{25919,25914,25803} Formulations containing amitriptyline have been used in the treatment of depression and nerve pain. This product is also available as an analytical reference standard (Item Nos. 19029 | 19031).
Brand:CaymanSKU:- Amitriptyline is a first generation tricyclic antidepressant that binds to the serotonin and norepinephrine transporters (Kds = 4.3 and 35 nM, respectively).{25873,22877} It is an antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (Ki =20 nM) as well as histamine H1, muscarinic acetylcholine, and α1-adrenergic receptors (Kis = 1.1, 18, and 27 nM, respectively).{25919,25914,25803} Formulations containing amitriptyline have been used in the treatment of depression and nerve pain. This product is also available as an analytical reference standard (Item Nos. 19029 | 19031).
Brand:CaymanSKU:- Amitriptyline is a first generation tricyclic antidepressant that binds to the serotonin and norepinephrine transporters (Kds = 4.3 and 35 nM, respectively).{25873,22877} It is an antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (Ki =20 nM) as well as histamine H1, muscarinic acetylcholine, and α1-adrenergic receptors (Kis = 1.1, 18, and 27 nM, respectively).{25919,25914,25803} Formulations containing amitriptyline have been used in the treatment of depression and nerve pain. This product is also available as an analytical reference standard (Item Nos. 19029 | 19031).
Brand:CaymanSKU:-
Amlexanox is an anti-inflammatory and anti-allergic compound which is useful in the amelioration of aphthous ulcers (canker sores), commonly used as a 5% topical oral paste.{22218,22215} By way of mechanism of action, amlexanox associates with the calcium-binding proteins S100A12 and S100A13, inhibits the release of FGF1, and, at 1 mM, induces changes in the actin cytoskeleton.{22216,22217} More recently, amlexanox has been found to inhibit the non-canonical IKK-ε and TANK-binding kinase 1.{22219}
Brand:CaymanSKU:- Amlexanox is an anti-inflammatory and anti-allergic compound which is useful in the amelioration of aphthous ulcers (canker sores), commonly used as a 5% topical oral paste.{22218,22215} By way of mechanism of action, amlexanox associates with the calcium-binding proteins S100A12 and S100A13, inhibits the release of FGF1, and, at 1 mM, induces changes in the actin cytoskeleton.{22216,22217} More recently, amlexanox has been found to inhibit the non-canonical IKK-ε and TANK-binding kinase 1.{22219}
Brand:CaymanSKU:- Amlexanox is an anti-inflammatory and anti-allergic compound which is useful in the amelioration of aphthous ulcers (canker sores), commonly used as a 5% topical oral paste.{22218,22215} By way of mechanism of action, amlexanox associates with the calcium-binding proteins S100A12 and S100A13, inhibits the release of FGF1, and, at 1 mM, induces changes in the actin cytoskeleton.{22216,22217} More recently, amlexanox has been found to inhibit the non-canonical IKK-ε and TANK-binding kinase 1.{22219}
Brand:CaymanSKU:-
Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle.{23674} Acting as a vasodilator, amlodipine reduces blood pressure by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance. It inhibits calcium-induced contractions in depolarized rat aorta with an IC50 value of 1.9 nM, displaying a slow rate of association and dissociation in isolated vascular and cardiac tissues. Amlodipine also demonstrates actions independent of L-type calcium channel blockade by regulating membrane fluidity and cholesterol deposition, stimulating nitric oxide production, acting as an antioxidant, and regulating matrix deposition in vitro and in vivo.{23673} Formulations containing amlodipine have been used in the treatment of hypertension.
Brand:CaymanSKU:- Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle.{23674} Acting as a vasodilator, amlodipine reduces blood pressure by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance. It inhibits calcium-induced contractions in depolarized rat aorta with an IC50 value of 1.9 nM, displaying a slow rate of association and dissociation in isolated vascular and cardiac tissues. Amlodipine also demonstrates actions independent of L-type calcium channel blockade by regulating membrane fluidity and cholesterol deposition, stimulating nitric oxide production, acting as an antioxidant, and regulating matrix deposition in vitro and in vivo.{23673} Formulations containing amlodipine have been used in the treatment of hypertension.
Brand:CaymanSKU:- Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle.{23674} Acting as a vasodilator, amlodipine reduces blood pressure by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance. It inhibits calcium-induced contractions in depolarized rat aorta with an IC50 value of 1.9 nM, displaying a slow rate of association and dissociation in isolated vascular and cardiac tissues. Amlodipine also demonstrates actions independent of L-type calcium channel blockade by regulating membrane fluidity and cholesterol deposition, stimulating nitric oxide production, acting as an antioxidant, and regulating matrix deposition in vitro and in vivo.{23673} Formulations containing amlodipine have been used in the treatment of hypertension.
Brand:CaymanSKU:-
Amlodipine-d4 is intended for use as an internal standard for the quantification of amlodipine (Item No. 14838) by GC- or LC-MS. Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle.{23674} Acting as a vasodilator, amlodipine reduces blood pressure by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance. It inhibits calcium-induced contractions in depolarized rat aorta with an IC50 value of 1.9 nM, displaying a slow rate of association and dissociation in isolated vascular and cardiac tissues.{23674} Amlodipine also demonstrates actions independent of L-type calcium channel blockade by regulating membrane fluidity and cholesterol deposition, stimulating nitric oxide production, acting as an antioxidant, and regulating matrix deposition in vitro and in vivo.{23673} Formulations containing amlodipine have been used in the treatment of hypertension.
Brand:CaymanSKU:25035 - 1 mgAvailable on backorder
Amlodipine-d4 is intended for use as an internal standard for the quantification of amlodipine (Item No. 14838) by GC- or LC-MS. Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle.{23674} Acting as a vasodilator, amlodipine reduces blood pressure by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance. It inhibits calcium-induced contractions in depolarized rat aorta with an IC50 value of 1.9 nM, displaying a slow rate of association and dissociation in isolated vascular and cardiac tissues.{23674} Amlodipine also demonstrates actions independent of L-type calcium channel blockade by regulating membrane fluidity and cholesterol deposition, stimulating nitric oxide production, acting as an antioxidant, and regulating matrix deposition in vitro and in vivo.{23673} Formulations containing amlodipine have been used in the treatment of hypertension.
Brand:CaymanSKU:25035 - 5 mgAvailable on backorder
AMN082 is an orally bioavailable allosteric agonist of metabotropic glutamate receptor 7 (mGluR7).{47688} It inhibits cAMP accumulation induced by forskolin in CHO cells expressing human mGluR7b (EC50 = 64 nM). AMN082 (10 μM) is selective for mGluR7a and mGluR7b over mGluR1b, mGluR4, and mGluR8a with 140, 90, 15, 18, and 20% activation, respectively, as well as over mGluR2, mGluR3, mGluR5a, mGluR6, GluR3, and NMDA receptors containing NR1a, NR2A, or NR2B subunits. AMN082 also binds to the norepinephrine transporter (NET) and α1-adrenergic receptor (α1-AR).{47689} It increases the proliferation of neural progenitor cells (NPCs) and induces their differentiation into neurons when used at a concentration of 1 μM.{47690} AMN082 (2.5 mg/kg) inhibits apomorphine-induced circling in a rat model of Parkinson’s disease induced by 6-hydroxy dopamine (6-OHDA; Item No. 25330).{47691}
Brand:CaymanSKU:28779 - 10 mgAvailable on backorder
AMN082 is an orally bioavailable allosteric agonist of metabotropic glutamate receptor 7 (mGluR7).{47688} It inhibits cAMP accumulation induced by forskolin in CHO cells expressing human mGluR7b (EC50 = 64 nM). AMN082 (10 μM) is selective for mGluR7a and mGluR7b over mGluR1b, mGluR4, and mGluR8a with 140, 90, 15, 18, and 20% activation, respectively, as well as over mGluR2, mGluR3, mGluR5a, mGluR6, GluR3, and NMDA receptors containing NR1a, NR2A, or NR2B subunits. AMN082 also binds to the norepinephrine transporter (NET) and α1-adrenergic receptor (α1-AR).{47689} It increases the proliferation of neural progenitor cells (NPCs) and induces their differentiation into neurons when used at a concentration of 1 μM.{47690} AMN082 (2.5 mg/kg) inhibits apomorphine-induced circling in a rat model of Parkinson’s disease induced by 6-hydroxy dopamine (6-OHDA; Item No. 25330).{47691}
Brand:CaymanSKU:28779 - 25 mgAvailable on backorder
AMN082 is an orally bioavailable allosteric agonist of metabotropic glutamate receptor 7 (mGluR7).{47688} It inhibits cAMP accumulation induced by forskolin in CHO cells expressing human mGluR7b (EC50 = 64 nM). AMN082 (10 μM) is selective for mGluR7a and mGluR7b over mGluR1b, mGluR4, and mGluR8a with 140, 90, 15, 18, and 20% activation, respectively, as well as over mGluR2, mGluR3, mGluR5a, mGluR6, GluR3, and NMDA receptors containing NR1a, NR2A, or NR2B subunits. AMN082 also binds to the norepinephrine transporter (NET) and α1-adrenergic receptor (α1-AR).{47689} It increases the proliferation of neural progenitor cells (NPCs) and induces their differentiation into neurons when used at a concentration of 1 μM.{47690} AMN082 (2.5 mg/kg) inhibits apomorphine-induced circling in a rat model of Parkinson’s disease induced by 6-hydroxy dopamine (6-OHDA; Item No. 25330).{47691}
Brand:CaymanSKU:28779 - 5 mgAvailable on backorder
Amodiaquine is a prodrug form of the antimalarial compound N-desethyl amodiaquine (Item No. 20822).{26895,26896} It is active against several strains of P. falciparum in vitro (EC50s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine.{26895} Amodiaquine dose-dependently inhibits development of parasitemia in a mouse model of P. berghei infection.{47585}
Brand:CaymanSKU:- Amodiaquine is a prodrug form of the antimalarial compound N-desethyl amodiaquine (Item No. 20822).{26895,26896} It is active against several strains of P. falciparum in vitro (EC50s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine.{26895} Amodiaquine dose-dependently inhibits development of parasitemia in a mouse model of P. berghei infection.{47585}
Brand:CaymanSKU:- Amodiaquine is a prodrug form of the antimalarial compound N-desethyl amodiaquine (Item No. 20822).{26895,26896} It is active against several strains of P. falciparum in vitro (EC50s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine.{26895} Amodiaquine dose-dependently inhibits development of parasitemia in a mouse model of P. berghei infection.{47585}
Brand:CaymanSKU:- Amodiaquine is a prodrug form of the antimalarial compound N-desethyl amodiaquine (Item No. 20822).{26895,26896} It is active against several strains of P. falciparum in vitro (EC50s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine.{26895} Amodiaquine dose-dependently inhibits development of parasitemia in a mouse model of P. berghei infection.{47585}
Brand:CaymanSKU:-
Amodiaquine-d10 is intended for use as an internal standard for the quantification of amodiaquine (Item No. 15954) by GC- or LC-MS. Amodiaquine is a prodrug form of the antimalarial compound N-desethyl amodiaquine (Item No. 20822).{26895,26896} It is active against several strains of P. falciparum in vitro (EC50s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine.{26895} Amodiaquine dose-dependently inhibits development of parasitemia in a mouse model of P. berghei infection.{47585}
Brand:CaymanSKU:28525 - 1 mgAvailable on backorder
Amonafide is a DNA-intercalating topoisomerase II poison.{59203} It reduces the formation of kinetoplast DNA minicircles, a marker of topoisomerase II activity, in a cell-free assay at 100 µM, but does not induce relaxation of supercoiled DNA, a marker of topoisomerase I activity, at the same concentration.{59204} Amonafide inhibits growth in a panel of 11 human cancer cell lines, including leukemia, gastric, breast, and lung cancer cells, with GI50 values ranging from 1 to 10 µM.{59205} It induces cell cycle arrest at the G2/M phase and apoptosis in AGS gastric and Huh7 hepatoma cancer cells, respectively, when used at concentrations ranging from 2.5 to 10 µM. Amonafide (5 mg/kg) reduces primary tumor growth and decreases pulmonary metastasis in a murine H22 hepatoma model.{59206}
Brand:CaymanSKU:31623 - 10 mgAvailable on backorder
Amonafide is a DNA-intercalating topoisomerase II poison.{59203} It reduces the formation of kinetoplast DNA minicircles, a marker of topoisomerase II activity, in a cell-free assay at 100 µM, but does not induce relaxation of supercoiled DNA, a marker of topoisomerase I activity, at the same concentration.{59204} Amonafide inhibits growth in a panel of 11 human cancer cell lines, including leukemia, gastric, breast, and lung cancer cells, with GI50 values ranging from 1 to 10 µM.{59205} It induces cell cycle arrest at the G2/M phase and apoptosis in AGS gastric and Huh7 hepatoma cancer cells, respectively, when used at concentrations ranging from 2.5 to 10 µM. Amonafide (5 mg/kg) reduces primary tumor growth and decreases pulmonary metastasis in a murine H22 hepatoma model.{59206}
Brand:CaymanSKU:31623 - 100 mgAvailable on backorder
Amonafide is a DNA-intercalating topoisomerase II poison.{59203} It reduces the formation of kinetoplast DNA minicircles, a marker of topoisomerase II activity, in a cell-free assay at 100 µM, but does not induce relaxation of supercoiled DNA, a marker of topoisomerase I activity, at the same concentration.{59204} Amonafide inhibits growth in a panel of 11 human cancer cell lines, including leukemia, gastric, breast, and lung cancer cells, with GI50 values ranging from 1 to 10 µM.{59205} It induces cell cycle arrest at the G2/M phase and apoptosis in AGS gastric and Huh7 hepatoma cancer cells, respectively, when used at concentrations ranging from 2.5 to 10 µM. Amonafide (5 mg/kg) reduces primary tumor growth and decreases pulmonary metastasis in a murine H22 hepatoma model.{59206}
Brand:CaymanSKU:31623 - 5 mgAvailable on backorder