Cayman

Showing 9001–9150 of 45550 results

  • Salbutamol (albuterol) is a selective β2-adrenergic partial agonist that is used as a bronchodilator.{25569} Its detection and chemical analysis is of interest in various clinical and doping abuse settings.{25237} Albuterol methyl ether is a process impurity product associated with salbutamol that may be detected in urine samples.{28822}  

     

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    Cayman
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  • Salbutamol (albuterol) is a selective β2-adrenergic partial agonist that is used as a bronchodilator.{25569} Its detection and chemical analysis is of interest in various clinical and doping abuse settings.{25237} Albuterol methyl ether is a process impurity product associated with salbutamol that may be detected in urine samples.{28822}  

     

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    Cayman
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  • Alcaftadine is a potent antagonist of the H1 histamine receptor (IC50 = 8.6 nM) with lower affinities for the H2 and H4 receptors (IC50s = 62 nM and 4.4 μM, respectively).{34359} This antiallergenic agent has anti-inflammatory and mast cell stabilizing effects.{34330} Alcaftadine has been shown to reduce edema and erythema in a guinea pig model of allergic conjunctivitis (ED50 = 0.1 mg/kg) more effectively than ketotifen (Item No. 20303) (ED50 = 1.0 mg/kg) and has been used in clinical formulations in eye drops for treatment of ocular itching associated with allergic conjunctivitis.{34359,34360} Alcaftadine also binds to 5-HT2A and 5-HT2C receptors (Kis = 2.5 and 1.5 μM, respectively).{34359}  

     

    Brand:
    Cayman
    SKU:21290 -

    Out of stock

  • Alcaftadine is a potent antagonist of the H1 histamine receptor (IC50 = 8.6 nM) with lower affinities for the H2 and H4 receptors (IC50s = 62 nM and 4.4 μM, respectively).{34359} This antiallergenic agent has anti-inflammatory and mast cell stabilizing effects.{34330} Alcaftadine has been shown to reduce edema and erythema in a guinea pig model of allergic conjunctivitis (ED50 = 0.1 mg/kg) more effectively than ketotifen (Item No. 20303) (ED50 = 1.0 mg/kg) and has been used in clinical formulations in eye drops for treatment of ocular itching associated with allergic conjunctivitis.{34359,34360} Alcaftadine also binds to 5-HT2A and 5-HT2C receptors (Kis = 2.5 and 1.5 μM, respectively).{34359}  

     

    Brand:
    Cayman
    SKU:21290 -

    Out of stock

  • Alcaftadine is a potent antagonist of the H1 histamine receptor (IC50 = 8.6 nM) with lower affinities for the H2 and H4 receptors (IC50s = 62 nM and 4.4 μM, respectively).{34359} This antiallergenic agent has anti-inflammatory and mast cell stabilizing effects.{34330} Alcaftadine has been shown to reduce edema and erythema in a guinea pig model of allergic conjunctivitis (ED50 = 0.1 mg/kg) more effectively than ketotifen (Item No. 20303) (ED50 = 1.0 mg/kg) and has been used in clinical formulations in eye drops for treatment of ocular itching associated with allergic conjunctivitis.{34359,34360} Alcaftadine also binds to 5-HT2A and 5-HT2C receptors (Kis = 2.5 and 1.5 μM, respectively).{34359}  

     

    Brand:
    Cayman
    SKU:21290 -

    Out of stock

  • Alcaftadine is a potent antagonist of the H1 histamine receptor (IC50 = 8.6 nM) with lower affinities for the H2 and H4 receptors (IC50s = 62 nM and 4.4 μM, respectively).{34359} This antiallergenic agent has anti-inflammatory and mast cell stabilizing effects.{34330} Alcaftadine has been shown to reduce edema and erythema in a guinea pig model of allergic conjunctivitis (ED50 = 0.1 mg/kg) more effectively than ketotifen (Item No. 20303) (ED50 = 1.0 mg/kg) and has been used in clinical formulations in eye drops for treatment of ocular itching associated with allergic conjunctivitis.{34359,34360} Alcaftadine also binds to 5-HT2A and 5-HT2C receptors (Kis = 2.5 and 1.5 μM, respectively).{34359}  

     

    Brand:
    Cayman
    SKU:21290 -

    Out of stock

  • Alclometasone dipropionate (ACM) is a corticosteroid.{41325} It reduces cutaneous anaphylaxis reactions induced by tuberculin or albumin in mice when administered topically (20 μl of a 0.1% solution). ACM also inhibits androgen-dependent cytochrome P450 activity and the O-depropylation activity of 7-alkoxy-coumarin O-dealkylase in a dose-dependent manner in male rats but has no effect on hepatic drug metabolism in female rats or mice of both sexes.{41326} Formulations containing ACM have been used to treat radiation and allergic contact dermatitis.  

     

    Brand:
    Cayman
    SKU:23901 - 10 mg

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  • Alclometasone dipropionate (ACM) is a corticosteroid.{41325} It reduces cutaneous anaphylaxis reactions induced by tuberculin or albumin in mice when administered topically (20 μl of a 0.1% solution). ACM also inhibits androgen-dependent cytochrome P450 activity and the O-depropylation activity of 7-alkoxy-coumarin O-dealkylase in a dose-dependent manner in male rats but has no effect on hepatic drug metabolism in female rats or mice of both sexes.{41326} Formulations containing ACM have been used to treat radiation and allergic contact dermatitis.  

     

    Brand:
    Cayman
    SKU:23901 - 25 mg

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  • Alclometasone dipropionate (ACM) is a corticosteroid.{41325} It reduces cutaneous anaphylaxis reactions induced by tuberculin or albumin in mice when administered topically (20 μl of a 0.1% solution). ACM also inhibits androgen-dependent cytochrome P450 activity and the O-depropylation activity of 7-alkoxy-coumarin O-dealkylase in a dose-dependent manner in male rats but has no effect on hepatic drug metabolism in female rats or mice of both sexes.{41326} Formulations containing ACM have been used to treat radiation and allergic contact dermatitis.  

     

    Brand:
    Cayman
    SKU:23901 - 5 mg

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  • Alda-1 is a selective aldehyde dehydrogenase 2 (ALDH2) agonist.{39173} This cell-permeable benzamide selectively enhances the activity of WT ALDH2*1 and the East Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-, 2.2-, and 11-fold increase in Vmax of 20 µg homozygous WT, heterozygous WT/mutant, and homozygous mutant tetramer, respectively, at 100 µM), while exhibiting no effect toward alcohol dehydrogenase 1, cytosolic ALDH1, or mitochondrial ALDH5. Alda-1 (20 µM) protects against ex vivo ischemic tissue damage to excised rat hearts (25% and 24% reduction in infarct size and creatine phosphokinase (CPK) release, respectively).{39172} Alda-1 also, at a dose of 8.5 mg/kg, reduces infarct size by 60% in anesthetized live rats.  

     

    Brand:
    Cayman
    SKU:21555 -

    Out of stock

  • Alda-1 is a selective aldehyde dehydrogenase 2 (ALDH2) agonist.{39173} This cell-permeable benzamide selectively enhances the activity of WT ALDH2*1 and the East Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-, 2.2-, and 11-fold increase in Vmax of 20 µg homozygous WT, heterozygous WT/mutant, and homozygous mutant tetramer, respectively, at 100 µM), while exhibiting no effect toward alcohol dehydrogenase 1, cytosolic ALDH1, or mitochondrial ALDH5. Alda-1 (20 µM) protects against ex vivo ischemic tissue damage to excised rat hearts (25% and 24% reduction in infarct size and creatine phosphokinase (CPK) release, respectively).{39172} Alda-1 also, at a dose of 8.5 mg/kg, reduces infarct size by 60% in anesthetized live rats.  

     

    Brand:
    Cayman
    SKU:21555 -

    Out of stock

  • Alda-1 is a selective aldehyde dehydrogenase 2 (ALDH2) agonist.{39173} This cell-permeable benzamide selectively enhances the activity of WT ALDH2*1 and the East Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-, 2.2-, and 11-fold increase in Vmax of 20 µg homozygous WT, heterozygous WT/mutant, and homozygous mutant tetramer, respectively, at 100 µM), while exhibiting no effect toward alcohol dehydrogenase 1, cytosolic ALDH1, or mitochondrial ALDH5. Alda-1 (20 µM) protects against ex vivo ischemic tissue damage to excised rat hearts (25% and 24% reduction in infarct size and creatine phosphokinase (CPK) release, respectively).{39172} Alda-1 also, at a dose of 8.5 mg/kg, reduces infarct size by 60% in anesthetized live rats.  

     

    Brand:
    Cayman
    SKU:21555 -

    Out of stock

  • Aldehyde dehydrogenases (ALDHs) represent a group of enzymes that oxidize a wide range of endogenous and exogenous aldehydes to their corresponding carboxylic acids, which affect both developmental and toxicological functions. Pharmacological inhibitors or activators of ALDH activity have been developed to examine the metabolism of alcohol as well as a number of pathological conditions, including cancer, Type II hyperprolinemia, Sjögren-Larsson Syndrome, Parkinson’s Disease, Cardiac Disease, and hyperammonemia. Cayman’s Aldehyde Dehydrogenase Assay provides a fluorescence-based method for detecting ALDH activity in tissue homogenates, cell culture samples, and purified ALDH preparations. In the assay, ALDH catalyzes the oxidation of acetaldehyde to acetic acid, along with the concomitant reduction of NAD+ to NADH. NADH reacts with the fluorometric developer to yield a highly fluorescent product which can be analyzed with an excitation wavelength of 530-540 nm and an emission wavelength of 585-595 nm.  

     

    Brand:
    Cayman
    SKU:700800 - 96 wells

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  • DNA is continually damaged by endogenous and environmental agents leading to the formation of abasic (apurinic/apyrimidinic, AP) sites that are disruptive to DNA synthesis. Aldehyde Reactive Probe (ARP) is a biotinylated reagent for the detection and quantification of AP sites in damaged DNA. ARP reacts with aldehyde groups formed when reactive oxygen species depurinate DNA, resulting in covalent linkage of biotin to these AP sites.{16234} The biotin-tagged DNA can then be detected using common avidin-conjugated reporters such as avidin-HRP. The ARP method is highly sensitive, enabling detection of 2.4 AP sites per 1×107 nucleotides of DNA.{16233}  

     

    Brand:
    Cayman
    SKU:10009350 - 10 mg

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  • DNA is continually damaged by endogenous and environmental agents leading to the formation of abasic (apurinic/apyrimidinic, AP) sites that are disruptive to DNA synthesis. Aldehyde Reactive Probe (ARP) is a biotinylated reagent for the detection and quantification of AP sites in damaged DNA. ARP reacts with aldehyde groups formed when reactive oxygen species depurinate DNA, resulting in covalent linkage of biotin to these AP sites.{16234} The biotin-tagged DNA can then be detected using common avidin-conjugated reporters such as avidin-HRP. The ARP method is highly sensitive, enabling detection of 2.4 AP sites per 1×107 nucleotides of DNA.{16233}  

     

    Brand:
    Cayman
    SKU:10009350 - 25 mg

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  • DNA is continually damaged by endogenous and environmental agents leading to the formation of abasic (apurinic/apyrimidinic, AP) sites that are disruptive to DNA synthesis. Aldehyde Reactive Probe (ARP) is a biotinylated reagent for the detection and quantification of AP sites in damaged DNA. ARP reacts with aldehyde groups formed when reactive oxygen species depurinate DNA, resulting in covalent linkage of biotin to these AP sites.{16234} The biotin-tagged DNA can then be detected using common avidin-conjugated reporters such as avidin-HRP. The ARP method is highly sensitive, enabling detection of 2.4 AP sites per 1×107 nucleotides of DNA.{16233}  

     

    Brand:
    Cayman
    SKU:10009350 - 5 mg

    Available on backorder

  • DNA is continually damaged by endogenous and environmental agents leading to the formation of abasic (apurinic/apyrimidinic, AP) sites that are disruptive to DNA synthesis. Aldehyde Reactive Probe (ARP) is a biotinylated reagent for the detection and quantification of AP sites in damaged DNA. ARP reacts with aldehyde groups formed when reactive oxygen species depurinate DNA, resulting in covalent linkage of biotin to these AP sites.{16234} The biotin-tagged DNA can then be detected using common avidin-conjugated reporters such as avidin-HRP. The ARP method is highly sensitive, enabling detection of 2.4 AP sites per 1×107 nucleotides of DNA.{16233}  

     

    Brand:
    Cayman
    SKU:10009350 - 50 mg

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  • Aldicarb is a carbamate pesticide that reversibly inhibits acetylcholinesterase.{30082} It is the active ingredient in mixtures used to control insect, mite, and nematode pests in agriculture. Aldicarb has a high acute mammalian toxicity (LD50 = 0.3-0.5 mg/kg) following oral or parenteral administration.{30082,30083} Aside from its use as a pesticide, aldicarb has applications as an acetylcholinesterase inhibitor for research purposes.{30084,30085}  

     

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    Cayman
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  • Aldicarb is a carbamate pesticide that reversibly inhibits acetylcholinesterase.{30082} It is the active ingredient in mixtures used to control insect, mite, and nematode pests in agriculture. Aldicarb has a high acute mammalian toxicity (LD50 = 0.3-0.5 mg/kg) following oral or parenteral administration.{30082,30083} Aside from its use as a pesticide, aldicarb has applications as an acetylcholinesterase inhibitor for research purposes.{30084,30085}  

     

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    Cayman
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  • Aldicarb sulfone is a metabolite and degradation product of the carbamate pesticide aldicarb (Item No. 18466).{36838} Aldicarb sulfone (100 μg/ml) reduces the number of male T. semipenetrans second-stage larvae that reach the third, fourth, and adult stages of development.  

     

    Brand:
    Cayman
    SKU:24210 - 100 mg

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  • Aldicarb sulfone is a metabolite and degradation product of the carbamate pesticide aldicarb (Item No. 18466).{36838} Aldicarb sulfone (100 μg/ml) reduces the number of male T. semipenetrans second-stage larvae that reach the third, fourth, and adult stages of development.  

     

    Brand:
    Cayman
    SKU:24210 - 25 mg

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  • Aldicarb sulfone is a metabolite and degradation product of the carbamate pesticide aldicarb (Item No. 18466).{36838} Aldicarb sulfone (100 μg/ml) reduces the number of male T. semipenetrans second-stage larvae that reach the third, fourth, and adult stages of development.  

     

    Brand:
    Cayman
    SKU:24210 - 50 mg

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  • Aldicarb sulfoxide is a metabolite and degradation product of the carbamate pesticide aldicarb (Item No. 18466).{36838} Aldicarb sulfoxide (10 μg/ml) reduces the number of male T. semipenetrans second-stage larvae that reach the third, fourth, and adult stages of development. It inhibits carboxylesterase and cholinesterase in zebrafish (IC50 = 10 μM for both).{36841}  

     

    Brand:
    Cayman
    SKU:24211 - 10 mg

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  • Aldicarb sulfoxide is a metabolite and degradation product of the carbamate pesticide aldicarb (Item No. 18466).{36838} Aldicarb sulfoxide (10 μg/ml) reduces the number of male T. semipenetrans second-stage larvae that reach the third, fourth, and adult stages of development. It inhibits carboxylesterase and cholinesterase in zebrafish (IC50 = 10 μM for both).{36841}  

     

    Brand:
    Cayman
    SKU:24211 - 25 mg

    Available on backorder

  • Aldicarb sulfoxide is a metabolite and degradation product of the carbamate pesticide aldicarb (Item No. 18466).{36838} Aldicarb sulfoxide (10 μg/ml) reduces the number of male T. semipenetrans second-stage larvae that reach the third, fourth, and adult stages of development. It inhibits carboxylesterase and cholinesterase in zebrafish (IC50 = 10 μM for both).{36841}  

     

    Brand:
    Cayman
    SKU:24211 - 5 mg

    Available on backorder

  • Aldicarb sulfoxide is a metabolite and degradation product of the carbamate pesticide aldicarb (Item No. 18466).{36838} Aldicarb sulfoxide (10 μg/ml) reduces the number of male T. semipenetrans second-stage larvae that reach the third, fourth, and adult stages of development. It inhibits carboxylesterase and cholinesterase in zebrafish (IC50 = 10 μM for both).{36841}  

     

    Brand:
    Cayman
    SKU:24211 - 50 mg

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  • Aldosterone is a steroid hormone secreted by the adrenal cortex and is the principle mineralocorticoid controlling sodium and potassium balance.{7629,7630} Its primary role is to promote unidirectional salt reabsorption in epithelial tissues. Aldosterone is synthesized from cholesterol in the zona glomerulosa of the adrenal cortex and its secretion is regulated via the renin-angiotensin system.{7628}  

     

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  • Aldosterone is a steroid hormone secreted by the adrenal cortex and is the principle mineralocorticoid controlling sodium and potassium balance.{7629,7630} Its primary role is to promote unidirectional salt reabsorption in epithelial tissues. Aldosterone is synthesized from cholesterol in the zona glomerulosa of the adrenal cortex and its secretion is regulated via the renin-angiotensin system.{7628}  

     

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    Cayman
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  • Aldosterone is a steroid hormone secreted by the adrenal cortex and is the principle mineralocorticoid controlling sodium and potassium balance.{7629,7630} Its primary role is to promote unidirectional salt reabsorption in epithelial tissues. Aldosterone is synthesized from cholesterol in the zona glomerulosa of the adrenal cortex and its secretion is regulated via the renin-angiotensin system.{7628}  

     

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    Cayman
    SKU:-
  • Aldosterone is a steroid hormone secreted by the adrenal cortex and is the principle mineralocorticoid controlling sodium and potassium balance.{7629,7630} Its primary role is to promote unidirectional salt reabsorption in epithelial tissues. Aldosterone is synthesized from cholesterol in the zona glomerulosa of the adrenal cortex and its secretion is regulated via the renin-angiotensin system.{7628}  

     

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    Cayman
    SKU:-
  • Aldosterone, a steroid hormone secreted by the adrenal cortex, is the principle mineralocorticoid controlling sodium and potassium balance. Serum aldosterone levels in normal upright adult individuals are generally less than 300 pg/ml. Only a fraction of urinary aldosterone is excreted intact, thus urinary excretion of aldosterone in normal adults is typically assessed as a combination of free aldosterone and aldosterone-18-glucuronide and is generally less than 20 µg/24 hr. Cayman’s Aldosterone ELISA Kit is a competitive assay that can be used for quantification of aldosterone in serum, plasma, urine, and other sample matrices. The assay has a range from 15.6-2,000 pg/ml and a sensitivity (80% B/B0) of approximately 30 pg/ml.  

     

    Brand:
    Cayman
    SKU:501090 - 480 wells

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  • Aldosterone, a steroid hormone secreted by the adrenal cortex, is the principle mineralocorticoid controlling sodium and potassium balance. Serum aldosterone levels in normal upright adult individuals are generally less than 300 pg/ml. Only a fraction of urinary aldosterone is excreted intact, thus urinary excretion of aldosterone in normal adults is typically assessed as a combination of free aldosterone and aldosterone-18-glucuronide and is generally less than 20 µg/24 hr. Cayman’s Aldosterone ELISA Kit is a competitive assay that can be used for quantification of aldosterone in serum, plasma, urine, and other sample matrices. The assay has a range from 15.6-2,000 pg/ml and a sensitivity (80% B/B0) of approximately 30 pg/ml.  

     

    Brand:
    Cayman
    SKU:501090 - 96 wells

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  • Brand:
    Cayman
    SKU:401094 - 100 ng

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  • Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts.{18288,18286} Alendronate is a nitrogen-containing bisphosphonate that is commonly used in the treatment of osteoporosis and other metabolic bone diseases.{18287,18285,18282} It inhibits bone resorption in vitro with an IC50 value of 2 nM.{18288} In vivo, alendronate significantly increases (or prevents a decrease in) bone mineral density and reduces vertebral fractures.{18285,18282,17616}  

     

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    Cayman
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  • Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts.{18288,18286} Alendronate is a nitrogen-containing bisphosphonate that is commonly used in the treatment of osteoporosis and other metabolic bone diseases.{18287,18285,18282} It inhibits bone resorption in vitro with an IC50 value of 2 nM.{18288} In vivo, alendronate significantly increases (or prevents a decrease in) bone mineral density and reduces vertebral fractures.{18285,18282,17616}  

     

    Brand:
    Cayman
    SKU:-
  • Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts.{18288,18286} Alendronate is a nitrogen-containing bisphosphonate that is commonly used in the treatment of osteoporosis and other metabolic bone diseases.{18287,18285,18282} It inhibits bone resorption in vitro with an IC50 value of 2 nM.{18288} In vivo, alendronate significantly increases (or prevents a decrease in) bone mineral density and reduces vertebral fractures.{18285,18282,17616}  

     

    Brand:
    Cayman
    SKU:-
  • Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts.{18288,18286} Alendronate is a nitrogen-containing bisphosphonate that is commonly used in the treatment of osteoporosis and other metabolic bone diseases.{18287,18285,18282} It inhibits bone resorption in vitro with an IC50 value of 2 nM.{18288} In vivo, alendronate significantly increases (or prevents a decrease in) bone mineral density and reduces vertebral fractures.{18285,18282,17616}  

     

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    Cayman
    SKU:-
  • Alexidine is an alkyl bis(biguanide) antiseptic which has been used in mouthwashes to eliminate plaque forming microorganisms.{22073} It binds to lipopolysaccharide and lipoteichoic acid and inhibits fungal phospholipase B (IC50 ~ 250 nM).{22077,22075} Alexidine also inhibits the mitochondrial phosphatase PTPMT1 (IC50 = 1.08 μM, in vitro) and induces apoptosis in cancer cell lines (ED50 = 1.8-2.6 μM).{22074,22076}  

     

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    Cayman
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  • Alexidine is an alkyl bis(biguanide) antiseptic which has been used in mouthwashes to eliminate plaque forming microorganisms.{22073} It binds to lipopolysaccharide and lipoteichoic acid and inhibits fungal phospholipase B (IC50 ~ 250 nM).{22077,22075} Alexidine also inhibits the mitochondrial phosphatase PTPMT1 (IC50 = 1.08 μM, in vitro) and induces apoptosis in cancer cell lines (ED50 = 1.8-2.6 μM).{22074,22076}  

     

    Brand:
    Cayman
    SKU:-
  • Alexidine is an alkyl bis(biguanide) antiseptic which has been used in mouthwashes to eliminate plaque forming microorganisms.{22073} It binds to lipopolysaccharide and lipoteichoic acid and inhibits fungal phospholipase B (IC50 ~ 250 nM).{22077,22075} Alexidine also inhibits the mitochondrial phosphatase PTPMT1 (IC50 = 1.08 μM, in vitro) and induces apoptosis in cancer cell lines (ED50 = 1.8-2.6 μM).{22074,22076}  

     

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    Cayman
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  • Aflutinib is an inhibitor of mutant EGFRs.{54445} It is selective for EGFRL858R, EGFRG719X, EGFRL858R, EGFRL861A, and EGFRT790M mutant EGFRs over wild-type EGFR. Aflutinib (10 and 30 mg/kg) reduces tumor growth in an EGFRL858R and EGFRT790M-expressing LU1868 non-small cell lung cancer (NSCLC) patient-derived xenograft (PDX) mouse model.  

     

    Brand:
    Cayman
    SKU:31473 - 10 mg

    Available on backorder

  • Aflutinib is an inhibitor of mutant EGFRs.{54445} It is selective for EGFRL858R, EGFRG719X, EGFRL858R, EGFRL861A, and EGFRT790M mutant EGFRs over wild-type EGFR. Aflutinib (10 and 30 mg/kg) reduces tumor growth in an EGFRL858R and EGFRT790M-expressing LU1868 non-small cell lung cancer (NSCLC) patient-derived xenograft (PDX) mouse model.  

     

    Brand:
    Cayman
    SKU:31473 - 25 mg

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  • Aflutinib is an inhibitor of mutant EGFRs.{54445} It is selective for EGFRL858R, EGFRG719X, EGFRL858R, EGFRL861A, and EGFRT790M mutant EGFRs over wild-type EGFR. Aflutinib (10 and 30 mg/kg) reduces tumor growth in an EGFRL858R and EGFRT790M-expressing LU1868 non-small cell lung cancer (NSCLC) patient-derived xenograft (PDX) mouse model.  

     

    Brand:
    Cayman
    SKU:31473 - 5 mg

    Available on backorder

  • Aflutinib is an inhibitor of mutant EGFRs.{54445} It is selective for EGFRL858R, EGFRG719X, EGFRL858R, EGFRL861A, and EGFRT790M mutant EGFRs over wild-type EGFR. Aflutinib (10 and 30 mg/kg) reduces tumor growth in an EGFRL858R and EGFRT790M-expressing LU1868 non-small cell lung cancer (NSCLC) patient-derived xenograft (PDX) mouse model.  

     

    Brand:
    Cayman
    SKU:31473 - 50 mg

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  • Alfuzosin is a post-synaptic α1-adrenergic receptor antagonist commonly used to improve lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH).{18261,18269} It displays high-affinity with non-selectivity for the three known human α1 adrenoceptors (pKi = 8.0, 8.0, and 8.5 for α1A, α1B, and α1D, respectively).{18268} Consistent with a role for α1 adrenoceptors in mediating contraction of smooth muscle, alfuzosin was first described as having anti-hypertensive effects with peripheral vasodilator properties.{18261} In patients with BPH, alfuzosin increases mean urinary flow rate and decreases residual volume.{18269} Alfuzosin produces minimal vasodilatory and sexual function side effects.{18262,18266,18267}  

     

    Brand:
    Cayman
    SKU:-
  • Alfuzosin is a post-synaptic α1-adrenergic receptor antagonist commonly used to improve lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH).{18261,18269} It displays high-affinity with non-selectivity for the three known human α1 adrenoceptors (pKi = 8.0, 8.0, and 8.5 for α1A, α1B, and α1D, respectively).{18268} Consistent with a role for α1 adrenoceptors in mediating contraction of smooth muscle, alfuzosin was first described as having anti-hypertensive effects with peripheral vasodilator properties.{18261} In patients with BPH, alfuzosin increases mean urinary flow rate and decreases residual volume.{18269} Alfuzosin produces minimal vasodilatory and sexual function side effects.{18262,18266,18267}  

     

    Brand:
    Cayman
    SKU:-
  • Alfuzosin is a post-synaptic α1-adrenergic receptor antagonist commonly used to improve lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH).{18261,18269} It displays high-affinity with non-selectivity for the three known human α1 adrenoceptors (pKi = 8.0, 8.0, and 8.5 for α1A, α1B, and α1D, respectively).{18268} Consistent with a role for α1 adrenoceptors in mediating contraction of smooth muscle, alfuzosin was first described as having anti-hypertensive effects with peripheral vasodilator properties.{18261} In patients with BPH, alfuzosin increases mean urinary flow rate and decreases residual volume.{18269} Alfuzosin produces minimal vasodilatory and sexual function side effects.{18262,18266,18267}  

     

    Brand:
    Cayman
    SKU:-
  • Alfuzosin is a post-synaptic α1-adrenergic receptor antagonist commonly used to improve lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH).{18261,18269} It displays high-affinity with non-selectivity for the three known human α1 adrenoceptors (pKi = 8.0, 8.0, and 8.5 for α1A, α1B, and α1D, respectively).{18268} Consistent with a role for α1 adrenoceptors in mediating contraction of smooth muscle, alfuzosin was first described as having anti-hypertensive effects with peripheral vasodilator properties.{18261} In patients with BPH, alfuzosin increases mean urinary flow rate and decreases residual volume.{18269} Alfuzosin produces minimal vasodilatory and sexual function side effects.{18262,18266,18267}  

     

    Brand:
    Cayman
    SKU:-
  • Aliskiren is a nonpeptide renin inhibitor (IC50 = 0.6 nM) that selectively binds to the S3 sub-pocket of renin, preventing the conversion of angiotensinogen to angiotensin I, thereby blocking eventual conversion to angiotensin II.{31535,12909} Thus, by blocking renin, aliskiren was designed to prevent angiotensin II-mediated arterial vasoconstriction and aldosterone production.{31535,10615} Aliskiren is orally bioavailable and, in combination with valsartan (Item No. 14178), was shown to reduce blood pressure in db/db mice.{21725}  

     

    Brand:
    Cayman
    SKU:19640 -

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  • Aliskiren is a nonpeptide renin inhibitor (IC50 = 0.6 nM) that selectively binds to the S3 sub-pocket of renin, preventing the conversion of angiotensinogen to angiotensin I, thereby blocking eventual conversion to angiotensin II.{31535,12909} Thus, by blocking renin, aliskiren was designed to prevent angiotensin II-mediated arterial vasoconstriction and aldosterone production.{31535,10615} Aliskiren is orally bioavailable and, in combination with valsartan (Item No. 14178), was shown to reduce blood pressure in db/db mice.{21725}  

     

    Brand:
    Cayman
    SKU:19640 -

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  • Aliskiren is a nonpeptide renin inhibitor (IC50 = 0.6 nM) that selectively binds to the S3 sub-pocket of renin, preventing the conversion of angiotensinogen to angiotensin I, thereby blocking eventual conversion to angiotensin II.{31535,12909} Thus, by blocking renin, aliskiren was designed to prevent angiotensin II-mediated arterial vasoconstriction and aldosterone production.{31535,10615} Aliskiren is orally bioavailable and, in combination with valsartan (Item No. 14178), was shown to reduce blood pressure in db/db mice.{21725}  

     

    Brand:
    Cayman
    SKU:19640 -

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  • Aliskiren is a nonpeptide renin inhibitor (IC50 = 0.6 nM) that selectively binds to the S3 sub-pocket of renin, preventing the conversion of angiotensinogen to angiotensin I, thereby blocking eventual conversion to angiotensin II.{31535,12909} Thus, by blocking renin, aliskiren was designed to prevent angiotensin II-mediated arterial vasoconstriction and aldosterone production.{31535,10615} Aliskiren is orally bioavailable and, in combination with valsartan (Item No. 14178), was shown to reduce blood pressure in db/db mice.{21725}  

     

    Brand:
    Cayman
    SKU:19640 -

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  • Alizapride is a dopamine D2 receptor antagonist.{45087,45088} It selectively inhibits [3H]haloperidol and [3H]spiperone binding to dopamine D2 receptors over [3H]WB 4101, [3H]clonidine, and [3H]dihydroalprenolol binding to α1-adrenergic, α2-adrenergic, and β-adrenergic receptors, respectively, in rat striatal membranes (IC50s = 340, 66, >10,000, >10,000, and >10,000 nM, respectively).{45087} It reduces apomorphine- and dopamine-induced decreases in gastrointestinal transit of charcoal dust in rats.{45088} Formulations containing alizapride have been used in the treatment of pre- and postoperative nausea.  

     

    Brand:
    Cayman
    SKU:25645 - 1 g

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  • Alizapride is a dopamine D2 receptor antagonist.{45087,45088} It selectively inhibits [3H]haloperidol and [3H]spiperone binding to dopamine D2 receptors over [3H]WB 4101, [3H]clonidine, and [3H]dihydroalprenolol binding to α1-adrenergic, α2-adrenergic, and β-adrenergic receptors, respectively, in rat striatal membranes (IC50s = 340, 66, >10,000, >10,000, and >10,000 nM, respectively).{45087} It reduces apomorphine- and dopamine-induced decreases in gastrointestinal transit of charcoal dust in rats.{45088} Formulations containing alizapride have been used in the treatment of pre- and postoperative nausea.  

     

    Brand:
    Cayman
    SKU:25645 - 100 mg

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  • Alizapride is a dopamine D2 receptor antagonist.{45087,45088} It selectively inhibits [3H]haloperidol and [3H]spiperone binding to dopamine D2 receptors over [3H]WB 4101, [3H]clonidine, and [3H]dihydroalprenolol binding to α1-adrenergic, α2-adrenergic, and β-adrenergic receptors, respectively, in rat striatal membranes (IC50s = 340, 66, >10,000, >10,000, and >10,000 nM, respectively).{45087} It reduces apomorphine- and dopamine-induced decreases in gastrointestinal transit of charcoal dust in rats.{45088} Formulations containing alizapride have been used in the treatment of pre- and postoperative nausea.  

     

    Brand:
    Cayman
    SKU:25645 - 250 mg

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  • Alizapride is a dopamine D2 receptor antagonist.{45087,45088} It selectively inhibits [3H]haloperidol and [3H]spiperone binding to dopamine D2 receptors over [3H]WB 4101, [3H]clonidine, and [3H]dihydroalprenolol binding to α1-adrenergic, α2-adrenergic, and β-adrenergic receptors, respectively, in rat striatal membranes (IC50s = 340, 66, >10,000, >10,000, and >10,000 nM, respectively).{45087} It reduces apomorphine- and dopamine-induced decreases in gastrointestinal transit of charcoal dust in rats.{45088} Formulations containing alizapride have been used in the treatment of pre- and postoperative nausea.  

     

    Brand:
    Cayman
    SKU:25645 - 50 mg

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  • Alizarin is a small molecule inhibitor of cytochrome P450 isoforms CYP1A1, CYP1A2, and CYP1B1 (IC50s = 6.2, 10, and 2.7 µM, respectively).{22084} Alizarin acts as an antioxidant against iodophenol-derived phenoxyl radicals, superoxide anion radicals, and lipid peroxidation in rat liver microsomes.{34371} It also reduces hepatic content of thiobarbituric acid-reactive substances and serum levels of alanine aminotransferase in poisoned rats.{34371} Alizarin is also used as a red dye to stain bacteria, human adipose-derived stem cells, multipotent adult progenitor cells, skin, hair, and keratin fibers.{22804,34372,34370}  

     

    Brand:
    Cayman
    SKU:11676 - 100 g

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  • Alizarin is a small molecule inhibitor of cytochrome P450 isoforms CYP1A1, CYP1A2, and CYP1B1 (IC50s = 6.2, 10, and 2.7 µM, respectively).{22084} Alizarin acts as an antioxidant against iodophenol-derived phenoxyl radicals, superoxide anion radicals, and lipid peroxidation in rat liver microsomes.{34371} It also reduces hepatic content of thiobarbituric acid-reactive substances and serum levels of alanine aminotransferase in poisoned rats.{34371} Alizarin is also used as a red dye to stain bacteria, human adipose-derived stem cells, multipotent adult progenitor cells, skin, hair, and keratin fibers.{22804,34372,34370}  

     

    Brand:
    Cayman
    SKU:11676 - 250 g

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  • Alizarin is a small molecule inhibitor of cytochrome P450 isoforms CYP1A1, CYP1A2, and CYP1B1 (IC50s = 6.2, 10, and 2.7 µM, respectively).{22084} Alizarin acts as an antioxidant against iodophenol-derived phenoxyl radicals, superoxide anion radicals, and lipid peroxidation in rat liver microsomes.{34371} It also reduces hepatic content of thiobarbituric acid-reactive substances and serum levels of alanine aminotransferase in poisoned rats.{34371} Alizarin is also used as a red dye to stain bacteria, human adipose-derived stem cells, multipotent adult progenitor cells, skin, hair, and keratin fibers.{22804,34372,34370}  

     

    Brand:
    Cayman
    SKU:11676 - 50 g

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  • Alizarin-3-methyliminodiacetic acid is a colorimetric dye for the detection of fluoride ions.{43187} It reacts with fluoride to form a lilac-blue complex which can be quantified colorimetrically at 620 nm to determine fluoride concentration. Alizarin-3-methyliminodiacetic acid has been used to visualize fluoride deposition and bone mineralization during development in medaka larvae.{43188} It is also an inhibitor of inducible nitric oxide synthase (iNOS; IC50 = 35 nM).{43189}  

     

    Brand:
    Cayman
    SKU:22890 - 1 g

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  • Alizarin-3-methyliminodiacetic acid is a colorimetric dye for the detection of fluoride ions.{43187} It reacts with fluoride to form a lilac-blue complex which can be quantified colorimetrically at 620 nm to determine fluoride concentration. Alizarin-3-methyliminodiacetic acid has been used to visualize fluoride deposition and bone mineralization during development in medaka larvae.{43188} It is also an inhibitor of inducible nitric oxide synthase (iNOS; IC50 = 35 nM).{43189}  

     

    Brand:
    Cayman
    SKU:22890 - 5 g

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  • Alizarin-3-methyliminodiacetic acid is a colorimetric dye for the detection of fluoride ions.{43187} It reacts with fluoride to form a lilac-blue complex which can be quantified colorimetrically at 620 nm to determine fluoride concentration. Alizarin-3-methyliminodiacetic acid has been used to visualize fluoride deposition and bone mineralization during development in medaka larvae.{43188} It is also an inhibitor of inducible nitric oxide synthase (iNOS; IC50 = 35 nM).{43189}  

     

    Brand:
    Cayman
    SKU:22890 - 500 mg

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  • ALK-IN-1 is an analog of AP26113, a phosphine oxide-containing ALK inhibitor. ALK-IN-1 potently inhibits ALK (IC50 = 0.07 nM) over IGF-1R and InsR (IC50s = 3.2 and 100 nM, respectively).{31299} It drives cell death in (ALK+) Karpas-299 lymphoma cells with an IC50 value of 41.5 nM, while killing (ALK-) U937 cells with an IC50 value of 1,718 nM.{31299}  

     

    Brand:
    Cayman
    SKU:-

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  • ALK-IN-1 is an analog of AP26113, a phosphine oxide-containing ALK inhibitor. ALK-IN-1 potently inhibits ALK (IC50 = 0.07 nM) over IGF-1R and InsR (IC50s = 3.2 and 100 nM, respectively).{31299} It drives cell death in (ALK+) Karpas-299 lymphoma cells with an IC50 value of 41.5 nM, while killing (ALK-) U937 cells with an IC50 value of 1,718 nM.{31299}  

     

    Brand:
    Cayman
    SKU:-

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  • ALK-IN-1 is an analog of AP26113, a phosphine oxide-containing ALK inhibitor. ALK-IN-1 potently inhibits ALK (IC50 = 0.07 nM) over IGF-1R and InsR (IC50s = 3.2 and 100 nM, respectively).{31299} It drives cell death in (ALK+) Karpas-299 lymphoma cells with an IC50 value of 41.5 nM, while killing (ALK-) U937 cells with an IC50 value of 1,718 nM.{31299}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • ALK-IN-1 is an analog of AP26113, a phosphine oxide-containing ALK inhibitor. ALK-IN-1 potently inhibits ALK (IC50 = 0.07 nM) over IGF-1R and InsR (IC50s = 3.2 and 100 nM, respectively).{31299} It drives cell death in (ALK+) Karpas-299 lymphoma cells with an IC50 value of 41.5 nM, while killing (ALK-) U937 cells with an IC50 value of 1,718 nM.{31299}  

     

    Brand:
    Cayman
    SKU:-

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  • ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively).{23565} This inhibitor demonstrated less potent activity (IC50s > 16 μM) when tested against a panel of 9 related kinases, including p38 MAPK and GSK3.{23565} At 25 μM, this compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription.{23566}  

     

    Brand:
    Cayman
    SKU:-
  • ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively).{23565} This inhibitor demonstrated less potent activity (IC50s > 16 μM) when tested against a panel of 9 related kinases, including p38 MAPK and GSK3.{23565} At 25 μM, this compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription.{23566}  

     

    Brand:
    Cayman
    SKU:-
  • ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively).{23565} This inhibitor demonstrated less potent activity (IC50s > 16 μM) when tested against a panel of 9 related kinases, including p38 MAPK and GSK3.{23565} At 25 μM, this compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription.{23566}  

     

    Brand:
    Cayman
    SKU:-
  • ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively).{23565} This inhibitor demonstrated less potent activity (IC50s > 16 μM) when tested against a panel of 9 related kinases, including p38 MAPK and GSK3.{23565} At 25 μM, this compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription.{23566}  

     

    Brand:
    Cayman
    SKU:-
  • Cayman’s Alkaline Phosphatase (ALP) Colorimetric Activity Assay Kit provides a convenient method of measuring ALP activity in serum, plasma, tissue samples, and cell lysates with a limit of detection of 0.5 U/L. Measurement of ALP activity is carried out by monitoring the dephosphorylation of the chromogenic substrate p-nitrophenyl phosphate (pNPP). In the first step, ALP dephosphorylates pNPP generating p-nitrophenol. In the second step, the phenolic hydroxyl group is deprotonated under alkaline conditions resulting in p-nitrophenolate, which yields an intense yellow color that can be measured using absorbance at 405 nm. Under circumstances in which ALP activity is rate limiting, the increase in absorbance at 405 nm is directly proportional to ALP activity in the sample.  

     

    Brand:
    Cayman
    SKU:701710 - 480 wells

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  • Alkannin is a naphthoquinone and enantiomer of shikonin (Item No. 14751) that has been found in A. tinctoria and has diverse biological activities.{23515,45363,45364,45365,45366} It inhibits tumor-specific pyruvate kinase M2 (PKM2; IC50 = 0.3 μM) with 20- and 10-fold selectivity over PKM1 and pyruvate kinase L (PKL), respectively.{23515} Alkannin inhibits proliferation of HCT116 and SW480 colorectal cancer cells with IC50 values of 2.38 and 4.53 μM, respectively.{45363} It halts the cell cycle at the G1 phase and induces apoptosis in HCT116 cells when used at a concentration of 3 μM. Alkannin (1 μM) increases levels of Hsp70 in untreated and UVB-irradiated HaCaT cells as well as inhibits UVB-induced DNA fragmentation and caspase-3 activity in HaCaT cells.{45364} It is active against methicillin-sensitive and -resistant S. aureus (MICs = 6.25 μg/ml) as well as vancomycin-sensitive and -resistant E. faecalis (MICs = 50 and 25 μg/ml, respectively).{45365} Alkannin scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (EC50 = 22 ppm).{45366}  

     

    Brand:
    Cayman
    SKU:25058 - 1 mg

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  • Alkannin is a naphthoquinone and enantiomer of shikonin (Item No. 14751) that has been found in A. tinctoria and has diverse biological activities.{23515,45363,45364,45365,45366} It inhibits tumor-specific pyruvate kinase M2 (PKM2; IC50 = 0.3 μM) with 20- and 10-fold selectivity over PKM1 and pyruvate kinase L (PKL), respectively.{23515} Alkannin inhibits proliferation of HCT116 and SW480 colorectal cancer cells with IC50 values of 2.38 and 4.53 μM, respectively.{45363} It halts the cell cycle at the G1 phase and induces apoptosis in HCT116 cells when used at a concentration of 3 μM. Alkannin (1 μM) increases levels of Hsp70 in untreated and UVB-irradiated HaCaT cells as well as inhibits UVB-induced DNA fragmentation and caspase-3 activity in HaCaT cells.{45364} It is active against methicillin-sensitive and -resistant S. aureus (MICs = 6.25 μg/ml) as well as vancomycin-sensitive and -resistant E. faecalis (MICs = 50 and 25 μg/ml, respectively).{45365} Alkannin scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (EC50 = 22 ppm).{45366}  

     

    Brand:
    Cayman
    SKU:25058 - 10 mg

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  • Alkannin is a naphthoquinone and enantiomer of shikonin (Item No. 14751) that has been found in A. tinctoria and has diverse biological activities.{23515,45363,45364,45365,45366} It inhibits tumor-specific pyruvate kinase M2 (PKM2; IC50 = 0.3 μM) with 20- and 10-fold selectivity over PKM1 and pyruvate kinase L (PKL), respectively.{23515} Alkannin inhibits proliferation of HCT116 and SW480 colorectal cancer cells with IC50 values of 2.38 and 4.53 μM, respectively.{45363} It halts the cell cycle at the G1 phase and induces apoptosis in HCT116 cells when used at a concentration of 3 μM. Alkannin (1 μM) increases levels of Hsp70 in untreated and UVB-irradiated HaCaT cells as well as inhibits UVB-induced DNA fragmentation and caspase-3 activity in HaCaT cells.{45364} It is active against methicillin-sensitive and -resistant S. aureus (MICs = 6.25 μg/ml) as well as vancomycin-sensitive and -resistant E. faecalis (MICs = 50 and 25 μg/ml, respectively).{45365} Alkannin scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (EC50 = 22 ppm).{45366}  

     

    Brand:
    Cayman
    SKU:25058 - 25 mg

    Available on backorder

  • Alkannin is a naphthoquinone and enantiomer of shikonin (Item No. 14751) that has been found in A. tinctoria and has diverse biological activities.{23515,45363,45364,45365,45366} It inhibits tumor-specific pyruvate kinase M2 (PKM2; IC50 = 0.3 μM) with 20- and 10-fold selectivity over PKM1 and pyruvate kinase L (PKL), respectively.{23515} Alkannin inhibits proliferation of HCT116 and SW480 colorectal cancer cells with IC50 values of 2.38 and 4.53 μM, respectively.{45363} It halts the cell cycle at the G1 phase and induces apoptosis in HCT116 cells when used at a concentration of 3 μM. Alkannin (1 μM) increases levels of Hsp70 in untreated and UVB-irradiated HaCaT cells as well as inhibits UVB-induced DNA fragmentation and caspase-3 activity in HaCaT cells.{45364} It is active against methicillin-sensitive and -resistant S. aureus (MICs = 6.25 μg/ml) as well as vancomycin-sensitive and -resistant E. faecalis (MICs = 50 and 25 μg/ml, respectively).{45365} Alkannin scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (EC50 = 22 ppm).{45366}  

     

    Brand:
    Cayman
    SKU:25058 - 5 mg

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  • Alkynyl-biotin is a form of biotin with a terminal alkyne group separated by two polyethylene glycol moieties. It is used to add biotin to other molecules bearing an azide group using a copper Cu(I)-catalyzed azide-alkyne cycloaddition reaction. Alkynyl-biotin has been used to add a biotin tag to a range of biochemicals, amino acids, proteins, and nucleotides that have been modified by the addition of an azide group.{33225,33226,33227} Alkynyl-biotin can also be used to capture sulfenic acid-modified proteins that have been tagged with the cell-permeable probe DAz-2 (Item No. 13382).{17444}  

     

    Brand:
    Cayman
    SKU:13038 - 1 mg

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  • Alkynyl-biotin is a form of biotin with a terminal alkyne group separated by two polyethylene glycol moieties. It is used to add biotin to other molecules bearing an azide group using a copper Cu(I)-catalyzed azide-alkyne cycloaddition reaction. Alkynyl-biotin has been used to add a biotin tag to a range of biochemicals, amino acids, proteins, and nucleotides that have been modified by the addition of an azide group.{33225,33226,33227} Alkynyl-biotin can also be used to capture sulfenic acid-modified proteins that have been tagged with the cell-permeable probe DAz-2 (Item No. 13382).{17444}  

     

    Brand:
    Cayman
    SKU:13038 - 10 mg

    Available on backorder

  • Alkynyl-biotin is a form of biotin with a terminal alkyne group separated by two polyethylene glycol moieties. It is used to add biotin to other molecules bearing an azide group using a copper Cu(I)-catalyzed azide-alkyne cycloaddition reaction. Alkynyl-biotin has been used to add a biotin tag to a range of biochemicals, amino acids, proteins, and nucleotides that have been modified by the addition of an azide group.{33225,33226,33227} Alkynyl-biotin can also be used to capture sulfenic acid-modified proteins that have been tagged with the cell-permeable probe DAz-2 (Item No. 13382).{17444}  

     

    Brand:
    Cayman
    SKU:13038 - 5 mg

    Available on backorder

  • all-cis-1,2,3-Docosahexaenoyl glycerol is a polyunsaturated triacylglycerol that contains all-cis docosahexaenoic acid (DHA; Item No. 90310) at the sn-1, sn-2, and sn-3 positions.  

     

    Brand:
    Cayman
    SKU:10009667 - 1 mg

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  • all-cis-1,2,3-Docosahexaenoyl glycerol is a polyunsaturated triacylglycerol that contains all-cis docosahexaenoic acid (DHA; Item No. 90310) at the sn-1, sn-2, and sn-3 positions.  

     

    Brand:
    Cayman
    SKU:10009667 - 10 mg

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  • all-cis-1,2,3-Docosahexaenoyl glycerol is a polyunsaturated triacylglycerol that contains all-cis docosahexaenoic acid (DHA; Item No. 90310) at the sn-1, sn-2, and sn-3 positions.  

     

    Brand:
    Cayman
    SKU:10009667 - 25 mg

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  • all-cis-1,2,3-Docosahexaenoyl glycerol is a polyunsaturated triacylglycerol that contains all-cis docosahexaenoic acid (DHA; Item No. 90310) at the sn-1, sn-2, and sn-3 positions.  

     

    Brand:
    Cayman
    SKU:10009667 - 5 mg

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  • Docosapentaenoic acid (DPA) (Item No. 90165) is a 22-carbon fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936} all-cis-4,7,10,13,16-DPA, also known as osbond acid, is an isomer of DPA. It is an ω-6 fatty acid formed by the elongation and desaturation of arachidonic acid (Item No. 90010). Levels of this fatty acid may be diminished during fatty acid desaturase syndrome and this may affect development.{27613} Upregulated expression of hepatic elongation of very long fatty acids protein 6 and increased levels of very long chain fatty acids, including all-cis-4,7,10,13,16-DPA, are characteristic of non-alcoholic steatohepatitis, a preneoplastic condition of hepatocellular carcinoma.{27614}  

     

    Brand:
    Cayman
    SKU:10008335 - 1 mg

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  • Docosapentaenoic acid (DPA) (Item No. 90165) is a 22-carbon fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936} all-cis-4,7,10,13,16-DPA, also known as osbond acid, is an isomer of DPA. It is an ω-6 fatty acid formed by the elongation and desaturation of arachidonic acid (Item No. 90010). Levels of this fatty acid may be diminished during fatty acid desaturase syndrome and this may affect development.{27613} Upregulated expression of hepatic elongation of very long fatty acids protein 6 and increased levels of very long chain fatty acids, including all-cis-4,7,10,13,16-DPA, are characteristic of non-alcoholic steatohepatitis, a preneoplastic condition of hepatocellular carcinoma.{27614}  

     

    Brand:
    Cayman
    SKU:10008335 - 10 mg

    Available on backorder

  • Docosapentaenoic acid (DPA) (Item No. 90165) is a 22-carbon fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936} all-cis-4,7,10,13,16-DPA, also known as osbond acid, is an isomer of DPA. It is an ω-6 fatty acid formed by the elongation and desaturation of arachidonic acid (Item No. 90010). Levels of this fatty acid may be diminished during fatty acid desaturase syndrome and this may affect development.{27613} Upregulated expression of hepatic elongation of very long fatty acids protein 6 and increased levels of very long chain fatty acids, including all-cis-4,7,10,13,16-DPA, are characteristic of non-alcoholic steatohepatitis, a preneoplastic condition of hepatocellular carcinoma.{27614}  

     

    Brand:
    Cayman
    SKU:10008335 - 25 mg

    Available on backorder

  • Docosapentaenoic acid (DPA) (Item No. 90165) is a 22-carbon fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans, ranging from 0.1 to 1%, and increases on dietary supplementation.{1936} all-cis-4,7,10,13,16-DPA, also known as osbond acid, is an isomer of DPA. It is an ω-6 fatty acid formed by the elongation and desaturation of arachidonic acid (Item No. 90010). Levels of this fatty acid may be diminished during fatty acid desaturase syndrome and this may affect development.{27613} Upregulated expression of hepatic elongation of very long fatty acids protein 6 and increased levels of very long chain fatty acids, including all-cis-4,7,10,13,16-DPA, are characteristic of non-alcoholic steatohepatitis, a preneoplastic condition of hepatocellular carcinoma.{27614}  

     

    Brand:
    Cayman
    SKU:10008335 - 5 mg

    Available on backorder

  • all-cis-4,7,10,13,16-Docosapentaenoic acid ethyl ester (all-cis-4,7,10,13,16-DPA ethyl ester) is a derivative of DPA (Item No. 90165), an ω-3 fatty acid found in fish oils. Ethyl ester derivatives of fatty acids, including DPA, are often used in formulations designed as dietary supplements.{16505,33057,33058}  

     

    Brand:
    Cayman
    SKU:23607 - 100 mg

    Available on backorder

  • all-cis-4,7,10,13,16-Docosapentaenoic acid ethyl ester (all-cis-4,7,10,13,16-DPA ethyl ester) is a derivative of DPA (Item No. 90165), an ω-3 fatty acid found in fish oils. Ethyl ester derivatives of fatty acids, including DPA, are often used in formulations designed as dietary supplements.{16505,33057,33058}  

     

    Brand:
    Cayman
    SKU:23607 - 25 mg

    Available on backorder

  • all-cis-4,7,10,13,16-Docosapentaenoic acid ethyl ester (all-cis-4,7,10,13,16-DPA ethyl ester) is a derivative of DPA (Item No. 90165), an ω-3 fatty acid found in fish oils. Ethyl ester derivatives of fatty acids, including DPA, are often used in formulations designed as dietary supplements.{16505,33057,33058}  

     

    Brand:
    Cayman
    SKU:23607 - 250 mg

    Available on backorder

  • all-cis-4,7,10,13,16-Docosapentaenoic acid ethyl ester (all-cis-4,7,10,13,16-DPA ethyl ester) is a derivative of DPA (Item No. 90165), an ω-3 fatty acid found in fish oils. Ethyl ester derivatives of fatty acids, including DPA, are often used in formulations designed as dietary supplements.{16505,33057,33058}  

     

    Brand:
    Cayman
    SKU:23607 - 5 mg

    Available on backorder

  • all-cis-4,7,10,13,16-Docosapentaenoic acid (all-cis-4,7,10,13,16-DPA) methyl ester is a more lipid-soluble form of the free acid (Item No. 10008335). all-cis-4,7,10,13,16-DPA, also known as osbond acid, is an isomer of DPA (Item No. 90165) an ω-3, 22-carbon fatty acid found in fish oils. It is an ω-6 fatty acid formed by the elongation and desaturation of arachidonic acid (Item No. 90010). Levels of all-cis-4,7,10,13,16-DPA fatty acid may be diminished during fatty acid desaturase syndrome and this may affect development.{27613} Upregulated expression of hepatic elongation of very long fatty acids protein 6 and increased levels of very long chain fatty acids, including all-cis-4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a preneoplastic condition of hepatocellular carcinoma.{27614}  

     

    Brand:
    Cayman
    SKU:21124 -

    Out of stock

  • all-cis-4,7,10,13,16-Docosapentaenoic acid (all-cis-4,7,10,13,16-DPA) methyl ester is a more lipid-soluble form of the free acid (Item No. 10008335). all-cis-4,7,10,13,16-DPA, also known as osbond acid, is an isomer of DPA (Item No. 90165) an ω-3, 22-carbon fatty acid found in fish oils. It is an ω-6 fatty acid formed by the elongation and desaturation of arachidonic acid (Item No. 90010). Levels of all-cis-4,7,10,13,16-DPA fatty acid may be diminished during fatty acid desaturase syndrome and this may affect development.{27613} Upregulated expression of hepatic elongation of very long fatty acids protein 6 and increased levels of very long chain fatty acids, including all-cis-4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a preneoplastic condition of hepatocellular carcinoma.{27614}  

     

    Brand:
    Cayman
    SKU:21124 -

    Out of stock

  • all-cis-4,7,10,13,16-Docosapentaenoic acid (all-cis-4,7,10,13,16-DPA) methyl ester is a more lipid-soluble form of the free acid (Item No. 10008335). all-cis-4,7,10,13,16-DPA, also known as osbond acid, is an isomer of DPA (Item No. 90165) an ω-3, 22-carbon fatty acid found in fish oils. It is an ω-6 fatty acid formed by the elongation and desaturation of arachidonic acid (Item No. 90010). Levels of all-cis-4,7,10,13,16-DPA fatty acid may be diminished during fatty acid desaturase syndrome and this may affect development.{27613} Upregulated expression of hepatic elongation of very long fatty acids protein 6 and increased levels of very long chain fatty acids, including all-cis-4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a preneoplastic condition of hepatocellular carcinoma.{27614}  

     

    Brand:
    Cayman
    SKU:21124 -

    Out of stock

  • all-cis-4,7,10,13,16-Docosapentaenoic acid (all-cis-4,7,10,13,16-DPA) methyl ester is a more lipid-soluble form of the free acid (Item No. 10008335). all-cis-4,7,10,13,16-DPA, also known as osbond acid, is an isomer of DPA (Item No. 90165) an ω-3, 22-carbon fatty acid found in fish oils. It is an ω-6 fatty acid formed by the elongation and desaturation of arachidonic acid (Item No. 90010). Levels of all-cis-4,7,10,13,16-DPA fatty acid may be diminished during fatty acid desaturase syndrome and this may affect development.{27613} Upregulated expression of hepatic elongation of very long fatty acids protein 6 and increased levels of very long chain fatty acids, including all-cis-4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a preneoplastic condition of hepatocellular carcinoma.{27614}  

     

    Brand:
    Cayman
    SKU:21124 -

    Out of stock

  • all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARα, RARβ, and RARγ, respectively, in radioligand binding assays.{34779} It induces expression of a luciferase reporter in COS-7 cells expressing RARα, RARβ, or RARγ (EC50s = 169, 9, and 2 nM, respectively). all-trans Retinoic acid (17 nmol) reduces papilloma formation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice.{36738} It reduces bile duct proliferation, hydroxyproline levels, and liver inflammation in a rat model of α-naphthylisothiocyanate-induced chronic cholestasis and reduces plasma levels of alkaline phosphatase and bile salts in the Mdr2-/- mouse model of cholestasis.{36739} all-trans Retinoic acid also reduces hepatic fat accumulation, triglycerides, body weight, and serum glucose levels in mice with Western diet-induced obesity.{36740}  

     

    Brand:
    Cayman
    SKU:11017 - 1 g

    Available on backorder

  • all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARα, RARβ, and RARγ, respectively, in radioligand binding assays.{34779} It induces expression of a luciferase reporter in COS-7 cells expressing RARα, RARβ, or RARγ (EC50s = 169, 9, and 2 nM, respectively). all-trans Retinoic acid (17 nmol) reduces papilloma formation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice.{36738} It reduces bile duct proliferation, hydroxyproline levels, and liver inflammation in a rat model of α-naphthylisothiocyanate-induced chronic cholestasis and reduces plasma levels of alkaline phosphatase and bile salts in the Mdr2-/- mouse model of cholestasis.{36739} all-trans Retinoic acid also reduces hepatic fat accumulation, triglycerides, body weight, and serum glucose levels in mice with Western diet-induced obesity.{36740}  

     

    Brand:
    Cayman
    SKU:11017 - 5 g

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  • all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARα, RARβ, and RARγ, respectively, in radioligand binding assays.{34779} It induces expression of a luciferase reporter in COS-7 cells expressing RARα, RARβ, or RARγ (EC50s = 169, 9, and 2 nM, respectively). all-trans Retinoic acid (17 nmol) reduces papilloma formation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice.{36738} It reduces bile duct proliferation, hydroxyproline levels, and liver inflammation in a rat model of α-naphthylisothiocyanate-induced chronic cholestasis and reduces plasma levels of alkaline phosphatase and bile salts in the Mdr2-/- mouse model of cholestasis.{36739} all-trans Retinoic acid also reduces hepatic fat accumulation, triglycerides, body weight, and serum glucose levels in mice with Western diet-induced obesity.{36740}  

     

    Brand:
    Cayman
    SKU:11017 - 50 mg

    Available on backorder

  • all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARα, RARβ, and RARγ, respectively, in radioligand binding assays.{34779} It induces expression of a luciferase reporter in COS-7 cells expressing RARα, RARβ, or RARγ (EC50s = 169, 9, and 2 nM, respectively). all-trans Retinoic acid (17 nmol) reduces papilloma formation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice.{36738} It reduces bile duct proliferation, hydroxyproline levels, and liver inflammation in a rat model of α-naphthylisothiocyanate-induced chronic cholestasis and reduces plasma levels of alkaline phosphatase and bile salts in the Mdr2-/- mouse model of cholestasis.{36739} all-trans Retinoic acid also reduces hepatic fat accumulation, triglycerides, body weight, and serum glucose levels in mice with Western diet-induced obesity.{36740}  

     

    Brand:
    Cayman
    SKU:11017 - 500 mg

    Available on backorder

  • all-trans Retinoyl β-D-glucuronide is a metabolite of all-trans retinoic acid (Item No. 11017) formed by the UDP-glucuronosyltransferase (UGT) system.{51003} It is rapidly converted to all-trans retinoic acid following in vitro or in vivo administration.{51004,51005}  

     

    Brand:
    Cayman
    SKU:28057 - 2 mg

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  • all-trans-4-hydroxy Retinoic acid is a metabolite of all-trans retinoic acid (Item No. 11017) formed by the cytochrome P450 (CYP) isoforms CYP26A1, B1, and C1.{34779,38575} It binds to retinoic acid receptors (RARs) with a lower affinity than other all-trans retinoic acid metabolites (IC50s = 606, 298, and 892 nM for RARα, RARβ, and RARγ, respectively, in a radioligand binding assay). It also transactivates RARs with a lower efficacy than other metabolites (EC50s = 791, 64, and 94 nM for RARα, RARβ, and RARγ, respectively) but induces transcription of a reporter plasmid equipotently. all-trans-4-hydroxy Retinoic acid inhibits cell growth, halts the cell cycle in the G1 phase, and induces differentiation of NB4 acute promyelocytic leukemia cells (EC50 = 79.8 nM).{34781}  

     

    Brand:
    Cayman
    SKU:21378 -

    Out of stock

  • all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR; EC50s = 77, 35, and 4 nM for RARα, RARβ, and RARγ, respectively).{34779} 5,6-epoxy RA (1 µM) also induces growth arrest of MCF-7 and NB4 cells in vitro.{34780, 34781} It is a natural metabolite of all-trans retinoic acid (Item No. 11017), which is a metabolite of vitamin A.{34778}  

     

    Brand:
    Cayman
    SKU:22124 -

    Out of stock

  • all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR; EC50s = 77, 35, and 4 nM for RARα, RARβ, and RARγ, respectively).{34779} 5,6-epoxy RA (1 µM) also induces growth arrest of MCF-7 and NB4 cells in vitro.{34780, 34781} It is a natural metabolite of all-trans retinoic acid (Item No. 11017), which is a metabolite of vitamin A.{34778}  

     

    Brand:
    Cayman
    SKU:22124 -

    Out of stock

  • all-trans-Retinal is a natural retinoid that is derived from vitamin A. It is the oxidation product of all-trans-retinol and associates with cellular retinol-binding protein-I (CRBP-I) and CRBP-II (Kds = 50 and 90 nM, respectively), which are involved in the intracellular transport of retinol.{14372} all-trans-Retinal is also an intermediate of the phototransduction pathway of photoreceptors, including rhodopsin and bacterial opsins.{29923} As a chemically reactive aldehyde, all-trans-retinal can form toxic conjugates with proteins and lipids, leading to degeneration of the retina.{29923}  

     

    Brand:
    Cayman
    SKU:-

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  • all-trans-Retinal is a natural retinoid that is derived from vitamin A. It is the oxidation product of all-trans-retinol and associates with cellular retinol-binding protein-I (CRBP-I) and CRBP-II (Kds = 50 and 90 nM, respectively), which are involved in the intracellular transport of retinol.{14372} all-trans-Retinal is also an intermediate of the phototransduction pathway of photoreceptors, including rhodopsin and bacterial opsins.{29923} As a chemically reactive aldehyde, all-trans-retinal can form toxic conjugates with proteins and lipids, leading to degeneration of the retina.{29923}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • all-trans-Retinal is a natural retinoid that is derived from vitamin A. It is the oxidation product of all-trans-retinol and associates with cellular retinol-binding protein-I (CRBP-I) and CRBP-II (Kds = 50 and 90 nM, respectively), which are involved in the intracellular transport of retinol.{14372} all-trans-Retinal is also an intermediate of the phototransduction pathway of photoreceptors, including rhodopsin and bacterial opsins.{29923} As a chemically reactive aldehyde, all-trans-retinal can form toxic conjugates with proteins and lipids, leading to degeneration of the retina.{29923}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • all-trans-Retinal is a natural retinoid that is derived from vitamin A. It is the oxidation product of all-trans-retinol and associates with cellular retinol-binding protein-I (CRBP-I) and CRBP-II (Kds = 50 and 90 nM, respectively), which are involved in the intracellular transport of retinol.{14372} all-trans-Retinal is also an intermediate of the phototransduction pathway of photoreceptors, including rhodopsin and bacterial opsins.{29923} As a chemically reactive aldehyde, all-trans-retinal can form toxic conjugates with proteins and lipids, leading to degeneration of the retina.{29923}  

     

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    Cayman
    SKU:-

    Available on backorder

  • Allantoin is a product of purine and uric acid metabolism.{45992} It is formed through oxidation of uric acid by urate oxidase in most mammals but is formed only through non-enzymatic oxidation by free radicals in humans. Urinary levels of allantoin are increased prior to the onset of Alzheimer’s disease symptoms in mice expressing mutations in amyloid precursor protein and tau (APP/tau) but not during the early/middle stage of the disease, indicating its potential use as a biomarker for predicting Alzheimer’s disease onset.{45993} Due to the formation of allantoin by free radicals in humans, increased urinary levels are a potential biomarker for oxidative stress status.{45992}  

     

    Brand:
    Cayman
    SKU:30204 - 100 g

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  • Allantoin is a product of purine and uric acid metabolism.{45992} It is formed through oxidation of uric acid by urate oxidase in most mammals but is formed only through non-enzymatic oxidation by free radicals in humans. Urinary levels of allantoin are increased prior to the onset of Alzheimer’s disease symptoms in mice expressing mutations in amyloid precursor protein and tau (APP/tau) but not during the early/middle stage of the disease, indicating its potential use as a biomarker for predicting Alzheimer’s disease onset.{45993} Due to the formation of allantoin by free radicals in humans, increased urinary levels are a potential biomarker for oxidative stress status.{45992}  

     

    Brand:
    Cayman
    SKU:30204 - 25 g

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  • Allethrin is a pyrethroid insecticide and modulator of voltage-gated sodium channels (NaV).{39796} It delays channel deactivation in cockroach giant axons when used at a concentration of 1 μM. Allethrin is 100-fold more potent at insect than rat NaV1.8 channels expressed in Xenopus oocytes.{36375} It decreases egg production by and is lethal to mosquitoes (LC50 = 0.01%).{39797} Allethrin induces production of reactive oxygen species (ROS), lipid peroxidation, and apoptosis in rat primary Leydig cells.{39798} In vivo, the smoke of an allethrin-based mosquito coil increases levels of the hepatic enzymes ALT and AST and induces hepatocyte apoptosis as well as emphysema and lung hyperplasia in mice.{39799}  

     

    Brand:
    Cayman
    SKU:24132 - 100 mg

    Available on backorder

  • Allethrin is a pyrethroid insecticide and modulator of voltage-gated sodium channels (NaV).{39796} It delays channel deactivation in cockroach giant axons when used at a concentration of 1 μM. Allethrin is 100-fold more potent at insect than rat NaV1.8 channels expressed in Xenopus oocytes.{36375} It decreases egg production by and is lethal to mosquitoes (LC50 = 0.01%).{39797} Allethrin induces production of reactive oxygen species (ROS), lipid peroxidation, and apoptosis in rat primary Leydig cells.{39798} In vivo, the smoke of an allethrin-based mosquito coil increases levels of the hepatic enzymes ALT and AST and induces hepatocyte apoptosis as well as emphysema and lung hyperplasia in mice.{39799}  

     

    Brand:
    Cayman
    SKU:24132 - 50 mg

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  • Allicin is a natural product originally isolated from A. sativum that has wide-ranging biological effects including antioxidative, anticancer, antimicrobial, and antifungal activities.{25626,36056,36054,36055} It inhibits the cysteine proteases cathepsin B and L, facipain 2, and rhodesain with Ki values of 8.6 and 9.3, 1.04, and 5.31 µM, respectively.{25625} It shows antiparasitic activity against P. falciparum (IC50 = 5.2 µM) and T. b. brucei (IC50 = 13.8 µM), the parasites that cause malaria and African sleeping sickness, respectively. Allicin (5-10 µM) dose-dependently inhibits cell adhesion, invasion, and migration in various lung adenocarcinoma cell lines.{36056} It also alters the balance of tissue inhibitors of matrix metalloproteinases (TIMPs) and matrix metalloproteinases (MMPs), decreases phosphorylation of Akt, and decreases PI3K/Akt signaling.  

     

    Brand:
    Cayman
    SKU:-
  • Allicin is a natural product originally isolated from A. sativum that has wide-ranging biological effects including antioxidative, anticancer, antimicrobial, and antifungal activities.{25626,36056,36054,36055} It inhibits the cysteine proteases cathepsin B and L, facipain 2, and rhodesain with Ki values of 8.6 and 9.3, 1.04, and 5.31 µM, respectively.{25625} It shows antiparasitic activity against P. falciparum (IC50 = 5.2 µM) and T. b. brucei (IC50 = 13.8 µM), the parasites that cause malaria and African sleeping sickness, respectively. Allicin (5-10 µM) dose-dependently inhibits cell adhesion, invasion, and migration in various lung adenocarcinoma cell lines.{36056} It also alters the balance of tissue inhibitors of matrix metalloproteinases (TIMPs) and matrix metalloproteinases (MMPs), decreases phosphorylation of Akt, and decreases PI3K/Akt signaling.  

     

    Brand:
    Cayman
    SKU:-
  • Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of the GPCR-like receptor, Smoothened (SMO).{21774} In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers.{27050} ALLO-1 is a SMO antagonist that inhibits both wild-type (IC50 = 50 nM) and mutant SMO, including the D473H SMO mutant (IC50s = 300-1000 nM).{29056} This compound binds to the SMO cysteine-rich domain, which is a different mechanism of interaction compared to other known SMO ligands that bind the transmembrane pocket.{29056,28806}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of the GPCR-like receptor, Smoothened (SMO).{21774} In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers.{27050} ALLO-1 is a SMO antagonist that inhibits both wild-type (IC50 = 50 nM) and mutant SMO, including the D473H SMO mutant (IC50s = 300-1000 nM).{29056} This compound binds to the SMO cysteine-rich domain, which is a different mechanism of interaction compared to other known SMO ligands that bind the transmembrane pocket.{29056,28806}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of the GPCR-like receptor, Smoothened (SMO).{21774} In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers.{27050} ALLO-1 is a SMO antagonist that inhibits both wild-type (IC50 = 50 nM) and mutant SMO, including the D473H SMO mutant (IC50s = 300-1000 nM).{29056} This compound binds to the SMO cysteine-rich domain, which is a different mechanism of interaction compared to other known SMO ligands that bind the transmembrane pocket.{29056,28806}  

     

    Brand:
    Cayman
    SKU:-

    Available on backorder

  • Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of the GPCR-like receptor, Smoothened (SMO).{21774} In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers.{27050} ALLO-1 is a SMO antagonist that inhibits both wild-type (IC50 = 50 nM) and mutant SMO, including the D473H SMO mutant (IC50s = 300-1000 nM).{29056} This compound binds to the SMO cysteine-rich domain, which is a different mechanism of interaction compared to other known SMO ligands that bind the transmembrane pocket.{29056,28806}  

     

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    Cayman
    SKU:-

    Available on backorder

  • Allocholic acid is a bile acid and an isomer of cholic acid (Item No. 20250).{53996} It is typically produced in the fetal or larval stages of development but has been found in adult mammals in the context of cancer or during liver regeneration in rats.{53996,53997} Allocholic acid is a precursor to petromyzonol (Item No. 98250), a bile acid of larval sea lamprey that acts as a migratory pheromone.{55234} The levels of allocholic acid are elevated in the plasma of mdr2-/- mice, a model of bile duct inflammation leading to hepatocellular carcinoma.{53998}  

     

    Brand:
    Cayman
    SKU:30415 - 1 mg

    Available on backorder

  • Allocholic acid is a bile acid and an isomer of cholic acid (Item No. 20250).{53996} It is typically produced in the fetal or larval stages of development but has been found in adult mammals in the context of cancer or during liver regeneration in rats.{53996,53997} Allocholic acid is a precursor to petromyzonol (Item No. 98250), a bile acid of larval sea lamprey that acts as a migratory pheromone.{55234} The levels of allocholic acid are elevated in the plasma of mdr2-/- mice, a model of bile duct inflammation leading to hepatocellular carcinoma.{53998}  

     

    Brand:
    Cayman
    SKU:30415 - 10 mg

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  • Allocholic acid is a bile acid and an isomer of cholic acid (Item No. 20250).{53996} It is typically produced in the fetal or larval stages of development but has been found in adult mammals in the context of cancer or during liver regeneration in rats.{53996,53997} Allocholic acid is a precursor to petromyzonol (Item No. 98250), a bile acid of larval sea lamprey that acts as a migratory pheromone.{55234} The levels of allocholic acid are elevated in the plasma of mdr2-/- mice, a model of bile duct inflammation leading to hepatocellular carcinoma.{53998}  

     

    Brand:
    Cayman
    SKU:30415 - 5 mg

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  • Alloisolithocholic acid (AILCA) is an allomonohydroxy bile acid.{53938,53939} It activates large-conductance calcium-activated potassium channels (BKCas; EC50 = 44.21 µM in Xenopus oocytes expressing human channels).{53938} AILCA (6 mg/kg) reduces hepatic bile flow and bile salt, cholesterol, and phospholipid secretion, as well as induces loss of microvilli and dilation of canaliculi in hepatocytes, markers of cholestasis, in rats.{53939}  

     

    Brand:
    Cayman
    SKU:29542 - 10 mg

    Available on backorder

  • Alloisolithocholic acid (AILCA) is an allomonohydroxy bile acid.{53938,53939} It activates large-conductance calcium-activated potassium channels (BKCas; EC50 = 44.21 µM in Xenopus oocytes expressing human channels).{53938} AILCA (6 mg/kg) reduces hepatic bile flow and bile salt, cholesterol, and phospholipid secretion, as well as induces loss of microvilli and dilation of canaliculi in hepatocytes, markers of cholestasis, in rats.{53939}  

     

    Brand:
    Cayman
    SKU:29542 - 25 mg

    Available on backorder

  • Alloisolithocholic acid (AILCA) is an allomonohydroxy bile acid.{53938,53939} It activates large-conductance calcium-activated potassium channels (BKCas; EC50 = 44.21 µM in Xenopus oocytes expressing human channels).{53938} AILCA (6 mg/kg) reduces hepatic bile flow and bile salt, cholesterol, and phospholipid secretion, as well as induces loss of microvilli and dilation of canaliculi in hepatocytes, markers of cholestasis, in rats.{53939}  

     

    Brand:
    Cayman
    SKU:29542 - 5 mg

    Available on backorder

  • Xanthine oxidoreductase mediates the successive oxidation of hypoxanthine and xanthine to produce uric acid. The enzyme can interconvert between xanthine dehydrogenase and xanthine oxidase activities through reversible sulfhydryl oxidation on specific cysteine residues. Both forms oxidize hypoxanthine and xanthine to uric acid. However the dehydrogenase simultaneously reduces nicotinamide adenine dinucleotide while the oxidase reduces oxygen to superoxide. Allopurinol is an isomer of hypoxanthine that inhibits xanthine oxidoreductase (IC50 values between 0.2 and 50 μM, depending on assay and cell type).{17631,17630} In vivo, allopurinol has been reported to effectively and safely lower serum and urinary uric acid levels and is also reported to be effective in the treatment of gout and hyperuricemia. Allopurinol is rapidly metabolized in vivo to the xanthine analog oxypurinol, which is a metabolite that clearly augments the therapeutic effect of allopurinol.{17632}  

     

    Brand:
    Cayman
    SKU:10012597 - 100 g

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  • Xanthine oxidoreductase mediates the successive oxidation of hypoxanthine and xanthine to produce uric acid. The enzyme can interconvert between xanthine dehydrogenase and xanthine oxidase activities through reversible sulfhydryl oxidation on specific cysteine residues. Both forms oxidize hypoxanthine and xanthine to uric acid. However the dehydrogenase simultaneously reduces nicotinamide adenine dinucleotide while the oxidase reduces oxygen to superoxide. Allopurinol is an isomer of hypoxanthine that inhibits xanthine oxidoreductase (IC50 values between 0.2 and 50 μM, depending on assay and cell type).{17631,17630} In vivo, allopurinol has been reported to effectively and safely lower serum and urinary uric acid levels and is also reported to be effective in the treatment of gout and hyperuricemia. Allopurinol is rapidly metabolized in vivo to the xanthine analog oxypurinol, which is a metabolite that clearly augments the therapeutic effect of allopurinol.{17632}  

     

    Brand:
    Cayman
    SKU:10012597 - 25 g

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  • Xanthine oxidoreductase mediates the successive oxidation of hypoxanthine and xanthine to produce uric acid. The enzyme can interconvert between xanthine dehydrogenase and xanthine oxidase activities through reversible sulfhydryl oxidation on specific cysteine residues. Both forms oxidize hypoxanthine and xanthine to uric acid. However the dehydrogenase simultaneously reduces nicotinamide adenine dinucleotide while the oxidase reduces oxygen to superoxide. Allopurinol is an isomer of hypoxanthine that inhibits xanthine oxidoreductase (IC50 values between 0.2 and 50 μM, depending on assay and cell type).{17631,17630} In vivo, allopurinol has been reported to effectively and safely lower serum and urinary uric acid levels and is also reported to be effective in the treatment of gout and hyperuricemia. Allopurinol is rapidly metabolized in vivo to the xanthine analog oxypurinol, which is a metabolite that clearly augments the therapeutic effect of allopurinol.{17632}  

     

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    Cayman
    SKU:10012597 - 50 g

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  • Allylescaline is a derivative of the phenethylamine escaline (Item No. 14107) in which an allyl group replaces the ethyl group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:9001982 - 1 mg

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  • Allylescaline is a derivative of the phenethylamine escaline (Item No. 14107) in which an allyl group replaces the ethyl group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:9001982 - 10 mg

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  • Allylescaline is a derivative of the phenethylamine escaline (Item No. 14107) in which an allyl group replaces the ethyl group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:9001982 - 5 mg

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  • Almorexant is a dual antagonist of orexin 1 receptor (OX1R) and OX2R (Kis = 4.7 and 0.9 nM, respectively, in a radioligand binding assay).{28150} It decreases the latency to persistent non-rapid eye movement (NREM) sleep and increases the duration of NREM and REM sleep in male rats when administered at a dose of 100 mg/kg.{49493} Almorexant (300 mg/kg) does not impair spatial learning and memory in the Morris water maze and does not reverse spatial memory impairments induced by scopolamine in rats.{49494}  

     

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    Cayman
    SKU:-
  • Almorexant is a dual antagonist of orexin 1 receptor (OX1R) and OX2R (Kis = 4.7 and 0.9 nM, respectively, in a radioligand binding assay).{28150} It decreases the latency to persistent non-rapid eye movement (NREM) sleep and increases the duration of NREM and REM sleep in male rats when administered at a dose of 100 mg/kg.{49493} Almorexant (300 mg/kg) does not impair spatial learning and memory in the Morris water maze and does not reverse spatial memory impairments induced by scopolamine in rats.{49494}  

     

    Brand:
    Cayman
    SKU:-
  • Almorexant is a dual antagonist of orexin 1 receptor (OX1R) and OX2R (Kis = 4.7 and 0.9 nM, respectively, in a radioligand binding assay).{28150} It decreases the latency to persistent non-rapid eye movement (NREM) sleep and increases the duration of NREM and REM sleep in male rats when administered at a dose of 100 mg/kg.{49493} Almorexant (300 mg/kg) does not impair spatial learning and memory in the Morris water maze and does not reverse spatial memory impairments induced by scopolamine in rats.{49494}  

     

    Brand:
    Cayman
    SKU:-
  • Almotriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 12 and 13 nM, respectively, in a radioligand binding assay).{47183} It is selective for human 5-HT1B and 5-HT1D receptors over rat 5-HT1A and human 5-HT2A and 5-HT4 receptors (IC50s = 0.85, 25.1, and 140 μM, respectively). Almotriptan induces contractions in isolated canine saphenous veins (EC50 = 394 nM) but not isolated rabbit renal or mesenteric arteries. It increases carotid vascular resistance in anesthetized cats (ED100 = 11 μg/kg, i.v.) without increasing blood pressure or heart rate.{47184} Formulations containing almotriptan have been used in the treatment of migraine headaches.  

     

    Brand:
    Cayman
    SKU:25646 - 10 mg

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  • Almotriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 12 and 13 nM, respectively, in a radioligand binding assay).{47183} It is selective for human 5-HT1B and 5-HT1D receptors over rat 5-HT1A and human 5-HT2A and 5-HT4 receptors (IC50s = 0.85, 25.1, and 140 μM, respectively). Almotriptan induces contractions in isolated canine saphenous veins (EC50 = 394 nM) but not isolated rabbit renal or mesenteric arteries. It increases carotid vascular resistance in anesthetized cats (ED100 = 11 μg/kg, i.v.) without increasing blood pressure or heart rate.{47184} Formulations containing almotriptan have been used in the treatment of migraine headaches.  

     

    Brand:
    Cayman
    SKU:25646 - 25 mg

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  • Almotriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 12 and 13 nM, respectively, in a radioligand binding assay).{47183} It is selective for human 5-HT1B and 5-HT1D receptors over rat 5-HT1A and human 5-HT2A and 5-HT4 receptors (IC50s = 0.85, 25.1, and 140 μM, respectively). Almotriptan induces contractions in isolated canine saphenous veins (EC50 = 394 nM) but not isolated rabbit renal or mesenteric arteries. It increases carotid vascular resistance in anesthetized cats (ED100 = 11 μg/kg, i.v.) without increasing blood pressure or heart rate.{47184} Formulations containing almotriptan have been used in the treatment of migraine headaches.  

     

    Brand:
    Cayman
    SKU:25646 - 5 mg

    Available on backorder

  • Almotriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 12 and 13 nM, respectively, in a radioligand binding assay).{47183} It is selective for human 5-HT1B and 5-HT1D receptors over rat 5-HT1A and human 5-HT2A and 5-HT4 receptors (IC50s = 0.85, 25.1, and 140 μM, respectively). Almotriptan induces contractions in isolated canine saphenous veins (EC50 = 394 nM) but not isolated rabbit renal or mesenteric arteries. It increases carotid vascular resistance in anesthetized cats (ED100 = 11 μg/kg, i.v.) without increasing blood pressure or heart rate.{47184} Formulations containing almotriptan have been used in the treatment of migraine headaches.  

     

    Brand:
    Cayman
    SKU:25646 - 50 mg

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  • Aloe-emodin is a hydroxyanthraquinone found in Aloe vera leaves that has potent laxative action by inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle.{28847} It also demonstrates anti-tumor activity (ED50s = 1-13 µM), inducing apoptosis in various cancer cells by increasing the production of reactive oxygen species.{28848,28849} Aloe-emodin is reported to have estrogenic activity as a phytoestrogen and has been shown to inhibit breast cancer cell proliferation by downregulating ERα protein levels, and thus, suppressing transcriptional activation of the receptor.{21490,28850}  

     

    Brand:
    Cayman
    SKU:11677 - 10 mg

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  • Aloe-emodin is a hydroxyanthraquinone found in Aloe vera leaves that has potent laxative action by inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle.{28847} It also demonstrates anti-tumor activity (ED50s = 1-13 µM), inducing apoptosis in various cancer cells by increasing the production of reactive oxygen species.{28848,28849} Aloe-emodin is reported to have estrogenic activity as a phytoestrogen and has been shown to inhibit breast cancer cell proliferation by downregulating ERα protein levels, and thus, suppressing transcriptional activation of the receptor.{21490,28850}  

     

    Brand:
    Cayman
    SKU:11677 - 100 mg

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  • Aloe-emodin is a hydroxyanthraquinone found in Aloe vera leaves that has potent laxative action by inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle.{28847} It also demonstrates anti-tumor activity (ED50s = 1-13 µM), inducing apoptosis in various cancer cells by increasing the production of reactive oxygen species.{28848,28849} Aloe-emodin is reported to have estrogenic activity as a phytoestrogen and has been shown to inhibit breast cancer cell proliferation by downregulating ERα protein levels, and thus, suppressing transcriptional activation of the receptor.{21490,28850}  

     

    Brand:
    Cayman
    SKU:11677 - 25 mg

    Available on backorder

  • Aloe-emodin is a hydroxyanthraquinone found in Aloe vera leaves that has potent laxative action by inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle.{28847} It also demonstrates anti-tumor activity (ED50s = 1-13 µM), inducing apoptosis in various cancer cells by increasing the production of reactive oxygen species.{28848,28849} Aloe-emodin is reported to have estrogenic activity as a phytoestrogen and has been shown to inhibit breast cancer cell proliferation by downregulating ERα protein levels, and thus, suppressing transcriptional activation of the receptor.{21490,28850}  

     

    Brand:
    Cayman
    SKU:11677 - 50 mg

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  • Aloesin is a C-glycosylated chromone compound found in aloe (Liliaceae) that inhibits tyrosinase (IC50 = 0.9 mM), an enzyme responsible for catalyzing the first step of the conversion of tyrosine to melanin.{23238} Derivatives of aloesin have been shown to exhibit free radical scavenging and anti-inflammatory activity.{23236} The antihyperpigmenting effects of aloesin have been explored in melanocytes.{23237}  

     

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    Cayman
    SKU:-
  • Aloesin is a C-glycosylated chromone compound found in aloe (Liliaceae) that inhibits tyrosinase (IC50 = 0.9 mM), an enzyme responsible for catalyzing the first step of the conversion of tyrosine to melanin.{23238} Derivatives of aloesin have been shown to exhibit free radical scavenging and anti-inflammatory activity.{23236} The antihyperpigmenting effects of aloesin have been explored in melanocytes.{23237}  

     

    Brand:
    Cayman
    SKU:-
  • Aloesin is a C-glycosylated chromone compound found in aloe (Liliaceae) that inhibits tyrosinase (IC50 = 0.9 mM), an enzyme responsible for catalyzing the first step of the conversion of tyrosine to melanin.{23238} Derivatives of aloesin have been shown to exhibit free radical scavenging and anti-inflammatory activity.{23236} The antihyperpigmenting effects of aloesin have been explored in melanocytes.{23237}  

     

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    Cayman
    SKU:-
  • Alofanib is an allosteric inhibitor of FGFR2.{58160,58161} It inhibits FGF2-induced phosphorylation of FGFR substrate 2 (FRS2α) in KATO III gastric carcinoma cells (IC50 = 50s = 370 and 210 nM, respectively). It inhibits proliferation of human umbilical vein endothelial cells (HUVECs) induced by basic FGF (bFGF; IC50 = 11 nM) and tube formation of SVEC4-10 endothelial cells when used at a concentration of 50 nM.{58160} It also inhibits migration of SVEC4-10 cells in a wound healing assay. Alofanib (50 mg/kg) decreases the number of microvessels in tumor tissue by 50% in a SKOV3 ovarian serous carcinoma mouse model. It reduces tumor growth in mouse xenograft models when administered at a dose of 30 mg/kg per day, and the degree of tumor volume reduction positively correlates with the expression level of FGFR2{58161}  

     

    Brand:
    Cayman
    SKU:31754 - 100 mg

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  • Alofanib is an allosteric inhibitor of FGFR2.{58160,58161} It inhibits FGF2-induced phosphorylation of FGFR substrate 2 (FRS2α) in KATO III gastric carcinoma cells (IC50 = 50s = 370 and 210 nM, respectively). It inhibits proliferation of human umbilical vein endothelial cells (HUVECs) induced by basic FGF (bFGF; IC50 = 11 nM) and tube formation of SVEC4-10 endothelial cells when used at a concentration of 50 nM.{58160} It also inhibits migration of SVEC4-10 cells in a wound healing assay. Alofanib (50 mg/kg) decreases the number of microvessels in tumor tissue by 50% in a SKOV3 ovarian serous carcinoma mouse model. It reduces tumor growth in mouse xenograft models when administered at a dose of 30 mg/kg per day, and the degree of tumor volume reduction positively correlates with the expression level of FGFR2{58161}  

     

    Brand:
    Cayman
    SKU:31754 - 25 mg

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  • Alofanib is an allosteric inhibitor of FGFR2.{58160,58161} It inhibits FGF2-induced phosphorylation of FGFR substrate 2 (FRS2α) in KATO III gastric carcinoma cells (IC50 = 50s = 370 and 210 nM, respectively). It inhibits proliferation of human umbilical vein endothelial cells (HUVECs) induced by basic FGF (bFGF; IC50 = 11 nM) and tube formation of SVEC4-10 endothelial cells when used at a concentration of 50 nM.{58160} It also inhibits migration of SVEC4-10 cells in a wound healing assay. Alofanib (50 mg/kg) decreases the number of microvessels in tumor tissue by 50% in a SKOV3 ovarian serous carcinoma mouse model. It reduces tumor growth in mouse xenograft models when administered at a dose of 30 mg/kg per day, and the degree of tumor volume reduction positively correlates with the expression level of FGFR2{58161}  

     

    Brand:
    Cayman
    SKU:31754 - 5 mg

    Available on backorder

  • Alofanib is an allosteric inhibitor of FGFR2.{58160,58161} It inhibits FGF2-induced phosphorylation of FGFR substrate 2 (FRS2α) in KATO III gastric carcinoma cells (IC50 = 50s = 370 and 210 nM, respectively). It inhibits proliferation of human umbilical vein endothelial cells (HUVECs) induced by basic FGF (bFGF; IC50 = 11 nM) and tube formation of SVEC4-10 endothelial cells when used at a concentration of 50 nM.{58160} It also inhibits migration of SVEC4-10 cells in a wound healing assay. Alofanib (50 mg/kg) decreases the number of microvessels in tumor tissue by 50% in a SKOV3 ovarian serous carcinoma mouse model. It reduces tumor growth in mouse xenograft models when administered at a dose of 30 mg/kg per day, and the degree of tumor volume reduction positively correlates with the expression level of FGFR2{58161}  

     

    Brand:
    Cayman
    SKU:31754 - 50 mg

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  • Alogliptin is an orally bioavailable dipeptidyl peptidase 4 (DPP-4) inhibitor (IC50 = 6.9 nM) that is selective for DPP-4 over DPP-2, DPP-8, DPP-9, prolyl endopeptidase, fibroblast activation protein (FAP), and tryptase (IC50s = >100,000 nM).{36524} It does not inhibit cytochrome P450 enzymes and does not block the human ether-a-go-go-related gene (hERG) channel when used at concentrations up to 30 μM.{36525} Alogliptin inhibits DPP-4 activity in vivo in rats, dogs, and cynomolgus monkeys (EC50s = 3.4, 4.9, and 5.6 ng/ml, respectively, in plasma).{36524} It increases plasma glucagon-like peptide-1 (GLP-1; Item No. 24460) and insulin levels and decreases blood glucose levels during an oral glucose challenge in Zucker fa/fa rats when administered at a dose of 10 mg/kg. Alogliptin (2.8 mg/kg per day) decreases plasma DPP-4 activity and increases GLP-1 levels in diabetic ob/ob mice when administered for 29 days.{36526} Formulations containing alogliptin have been used as an adjunct treatment for type 2 diabetes mellitus.  

     

    Brand:
    Cayman
    SKU:23768 - 100 mg

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  • Alogliptin is an orally bioavailable dipeptidyl peptidase 4 (DPP-4) inhibitor (IC50 = 6.9 nM) that is selective for DPP-4 over DPP-2, DPP-8, DPP-9, prolyl endopeptidase, fibroblast activation protein (FAP), and tryptase (IC50s = >100,000 nM).{36524} It does not inhibit cytochrome P450 enzymes and does not block the human ether-a-go-go-related gene (hERG) channel when used at concentrations up to 30 μM.{36525} Alogliptin inhibits DPP-4 activity in vivo in rats, dogs, and cynomolgus monkeys (EC50s = 3.4, 4.9, and 5.6 ng/ml, respectively, in plasma).{36524} It increases plasma glucagon-like peptide-1 (GLP-1; Item No. 24460) and insulin levels and decreases blood glucose levels during an oral glucose challenge in Zucker fa/fa rats when administered at a dose of 10 mg/kg. Alogliptin (2.8 mg/kg per day) decreases plasma DPP-4 activity and increases GLP-1 levels in diabetic ob/ob mice when administered for 29 days.{36526} Formulations containing alogliptin have been used as an adjunct treatment for type 2 diabetes mellitus.  

     

    Brand:
    Cayman
    SKU:23768 - 25 mg

    Available on backorder

  • Alogliptin is an orally bioavailable dipeptidyl peptidase 4 (DPP-4) inhibitor (IC50 = 6.9 nM) that is selective for DPP-4 over DPP-2, DPP-8, DPP-9, prolyl endopeptidase, fibroblast activation protein (FAP), and tryptase (IC50s = >100,000 nM).{36524} It does not inhibit cytochrome P450 enzymes and does not block the human ether-a-go-go-related gene (hERG) channel when used at concentrations up to 30 μM.{36525} Alogliptin inhibits DPP-4 activity in vivo in rats, dogs, and cynomolgus monkeys (EC50s = 3.4, 4.9, and 5.6 ng/ml, respectively, in plasma).{36524} It increases plasma glucagon-like peptide-1 (GLP-1; Item No. 24460) and insulin levels and decreases blood glucose levels during an oral glucose challenge in Zucker fa/fa rats when administered at a dose of 10 mg/kg. Alogliptin (2.8 mg/kg per day) decreases plasma DPP-4 activity and increases GLP-1 levels in diabetic ob/ob mice when administered for 29 days.{36526} Formulations containing alogliptin have been used as an adjunct treatment for type 2 diabetes mellitus.  

     

    Brand:
    Cayman
    SKU:23768 - 250 mg

    Available on backorder

  • Alogliptin is an orally bioavailable dipeptidyl peptidase 4 (DPP-4) inhibitor (IC50 = 6.9 nM) that is selective for DPP-4 over DPP-2, DPP-8, DPP-9, prolyl endopeptidase, fibroblast activation protein (FAP), and tryptase (IC50s = >100,000 nM).{36524} It does not inhibit cytochrome P450 enzymes and does not block the human ether-a-go-go-related gene (hERG) channel when used at concentrations up to 30 μM.{36525} Alogliptin inhibits DPP-4 activity in vivo in rats, dogs, and cynomolgus monkeys (EC50s = 3.4, 4.9, and 5.6 ng/ml, respectively, in plasma).{36524} It increases plasma glucagon-like peptide-1 (GLP-1; Item No. 24460) and insulin levels and decreases blood glucose levels during an oral glucose challenge in Zucker fa/fa rats when administered at a dose of 10 mg/kg. Alogliptin (2.8 mg/kg per day) decreases plasma DPP-4 activity and increases GLP-1 levels in diabetic ob/ob mice when administered for 29 days.{36526} Formulations containing alogliptin have been used as an adjunct treatment for type 2 diabetes mellitus.  

     

    Brand:
    Cayman
    SKU:23768 - 50 mg

    Available on backorder