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7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol is a benzopyrene derivative that is activated by hepatic cytosol into electrophilic sulfuric acid esters, which are capable of forming covalent DNA adducts and inducing mutations.{26509,26510}
Brand:CaymanSKU:- 7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol is a benzopyrene derivative that is activated by hepatic cytosol into electrophilic sulfuric acid esters, which are capable of forming covalent DNA adducts and inducing mutations.{26509,26510}
Brand:CaymanSKU:- 7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol is a benzopyrene derivative that is activated by hepatic cytosol into electrophilic sulfuric acid esters, which are capable of forming covalent DNA adducts and inducing mutations.{26509,26510}
Brand:CaymanSKU:-
7′-methoxy NABUTIE (Item No. 22630) is an analytical reference standard categorized as a synthetic cannabinoid.{23277} This product is intended for research and forensic applications.
Brand:CaymanSKU:22630 -Out of stock
7′-methoxy NABUTIE (Item No. 22630) is an analytical reference standard categorized as a synthetic cannabinoid.{23277} This product is intended for research and forensic applications.
Brand:CaymanSKU:22630 -Out of stock
Novel oxylipins, referred to as docosanoids, have been derived from C22 polyunsaturated fatty acids 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic acid (7(S),17(S)-hydroxy DPA) is a DPA-derived analog of the 17(S)-dihydroxy series of docosanoids known as protectins. Protectin D1, a DHA-derived dihydroxy fatty acid, exhibits potent anti-inflammatory activities.{14974,14973,14972} Potentially, 7(S),17(S)-hydroxy DPA demonstrates similar properties; however, its biological activity has yet to be determined.
Brand:CaymanSKU:10546 - 100 µgAvailable on backorder
Novel oxylipins, referred to as docosanoids, have been derived from C22 polyunsaturated fatty acids 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic acid (7(S),17(S)-hydroxy DPA) is a DPA-derived analog of the 17(S)-dihydroxy series of docosanoids known as protectins. Protectin D1, a DHA-derived dihydroxy fatty acid, exhibits potent anti-inflammatory activities.{14974,14973,14972} Potentially, 7(S),17(S)-hydroxy DPA demonstrates similar properties; however, its biological activity has yet to be determined.
Brand:CaymanSKU:10546 - 25 µgAvailable on backorder
Novel oxylipins, referred to as docosanoids, have been derived from C22 polyunsaturated fatty acids 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic acid (7(S),17(S)-hydroxy DPA) is a DPA-derived analog of the 17(S)-dihydroxy series of docosanoids known as protectins. Protectin D1, a DHA-derived dihydroxy fatty acid, exhibits potent anti-inflammatory activities.{14974,14973,14972} Potentially, 7(S),17(S)-hydroxy DPA demonstrates similar properties; however, its biological activity has yet to be determined.
Brand:CaymanSKU:10546 - 50 µgAvailable on backorder
7(Z)-Pentacosene is an unsaturated cuticular hydrocarbon that acts as a contact sex pheromone in fruit flies. In different species and genotypes of Drosophila, it can be found on both males and females.{16828,17569,17568} Pentacosene may stimulate copulation either by itself at high concentrations{16279} or when combined with other alkenes. Interestingly, the absolute level of pentacosene increases in Drosophila females immediately after copulation.{17568,16828}
Brand:CaymanSKU:9000530 - 1 mgAvailable on backorder
7(Z)-Pentacosene is an unsaturated cuticular hydrocarbon that acts as a contact sex pheromone in fruit flies. In different species and genotypes of Drosophila, it can be found on both males and females.{16828,17569,17568} Pentacosene may stimulate copulation either by itself at high concentrations{16279} or when combined with other alkenes. Interestingly, the absolute level of pentacosene increases in Drosophila females immediately after copulation.{17568,16828}
Brand:CaymanSKU:9000530 - 10 mgAvailable on backorder
7(Z)-Pentacosene is an unsaturated cuticular hydrocarbon that acts as a contact sex pheromone in fruit flies. In different species and genotypes of Drosophila, it can be found on both males and females.{16828,17569,17568} Pentacosene may stimulate copulation either by itself at high concentrations{16279} or when combined with other alkenes. Interestingly, the absolute level of pentacosene increases in Drosophila females immediately after copulation.{17568,16828}
Brand:CaymanSKU:9000530 - 5 mgAvailable on backorder
7(Z)-Pentacosene is an unsaturated cuticular hydrocarbon that acts as a contact sex pheromone in fruit flies. In different species and genotypes of Drosophila, it can be found on both males and females.{16828,17569,17568} Pentacosene may stimulate copulation either by itself at high concentrations{16279} or when combined with other alkenes. Interestingly, the absolute level of pentacosene increases in Drosophila females immediately after copulation.{17568,16828}
Brand:CaymanSKU:9000530 - 50 mgAvailable on backorder
7(Z)-Tricosene is an unsaturated cuticular hydrocarbon that acts as a pheromone in some insects, including Drosophila. While it is present in both sexes of some Drosophila species, it is abundant in males, but not females, of D. melanogaster and D. sechellia.{16894} In these species, 7(Z)-tricosene prevents or reduces male courtship behavior{16914} and increases female sexual receptivity.{16915} It is absent from virgin D. melanogaster females, but is transferred from males to females during mating.{16916} In addition, mating induces the synthesis of 7(Z)-tricosene by D. melanogaster females, so that it acts as an anti-aphrodisiac in mated females.{16916} 7(Z)-Tricosene is also a minor component of labial gland secretion and cuticle of Bombus spp.{16895,16896}
Brand:CaymanSKU:9000313 - 1 mgAvailable on backorder
7(Z)-Tricosene is an unsaturated cuticular hydrocarbon that acts as a pheromone in some insects, including Drosophila. While it is present in both sexes of some Drosophila species, it is abundant in males, but not females, of D. melanogaster and D. sechellia.{16894} In these species, 7(Z)-tricosene prevents or reduces male courtship behavior{16914} and increases female sexual receptivity.{16915} It is absent from virgin D. melanogaster females, but is transferred from males to females during mating.{16916} In addition, mating induces the synthesis of 7(Z)-tricosene by D. melanogaster females, so that it acts as an anti-aphrodisiac in mated females.{16916} 7(Z)-Tricosene is also a minor component of labial gland secretion and cuticle of Bombus spp.{16895,16896}
Brand:CaymanSKU:9000313 - 10 mgAvailable on backorder
7(Z)-Tricosene is an unsaturated cuticular hydrocarbon that acts as a pheromone in some insects, including Drosophila. While it is present in both sexes of some Drosophila species, it is abundant in males, but not females, of D. melanogaster and D. sechellia.{16894} In these species, 7(Z)-tricosene prevents or reduces male courtship behavior{16914} and increases female sexual receptivity.{16915} It is absent from virgin D. melanogaster females, but is transferred from males to females during mating.{16916} In addition, mating induces the synthesis of 7(Z)-tricosene by D. melanogaster females, so that it acts as an anti-aphrodisiac in mated females.{16916} 7(Z)-Tricosene is also a minor component of labial gland secretion and cuticle of Bombus spp.{16895,16896}
Brand:CaymanSKU:9000313 - 5 mgAvailable on backorder
7(Z)-Tricosene is an unsaturated cuticular hydrocarbon that acts as a pheromone in some insects, including Drosophila. While it is present in both sexes of some Drosophila species, it is abundant in males, but not females, of D. melanogaster and D. sechellia.{16894} In these species, 7(Z)-tricosene prevents or reduces male courtship behavior{16914} and increases female sexual receptivity.{16915} It is absent from virgin D. melanogaster females, but is transferred from males to females during mating.{16916} In addition, mating induces the synthesis of 7(Z)-tricosene by D. melanogaster females, so that it acts as an anti-aphrodisiac in mated females.{16916} 7(Z)-Tricosene is also a minor component of labial gland secretion and cuticle of Bombus spp.{16895,16896}
Brand:CaymanSKU:9000313 - 50 mgAvailable on backorder
4(Z),7(Z),10(Z),13(Z),16(Z)-N-(2-hydroxyethyl)-Docosapentaenamide is a long-chain ω-3 fatty acid with a hydroxyethylamide group attached at the alpha chain.
Brand:CaymanSKU:- 4(Z),7(Z),10(Z),13(Z),16(Z)-N-(2-hydroxyethyl)-Docosapentaenamide is a long-chain ω-3 fatty acid with a hydroxyethylamide group attached at the alpha chain.
Brand:CaymanSKU:- 4(Z),7(Z),10(Z),13(Z),16(Z)-N-(2-hydroxyethyl)-Docosapentaenamide is a long-chain ω-3 fatty acid with a hydroxyethylamide group attached at the alpha chain.
Brand:CaymanSKU:-
The mating and social behaviors of insects are largely orchestrated by a suite of volatile cuticular hydrocarbon pheromones. 7(Z),11(Z)-Heptacosadiene is the predominant female-specific courtship pheromone of the fruit fly D. melanogaster. At amounts above 100 ng, 7(Z),11(Z)-heptacosadiene elicits wing vibrations in male D. melanogaster flies in a dose-dependent manner.{16279}
Brand:CaymanSKU:10012567 - 1 mgAvailable on backorder
The mating and social behaviors of insects are largely orchestrated by a suite of volatile cuticular hydrocarbon pheromones. 7(Z),11(Z)-Heptacosadiene is the predominant female-specific courtship pheromone of the fruit fly D. melanogaster. At amounts above 100 ng, 7(Z),11(Z)-heptacosadiene elicits wing vibrations in male D. melanogaster flies in a dose-dependent manner.{16279}
Brand:CaymanSKU:10012567 - 10 mgAvailable on backorder
The mating and social behaviors of insects are largely orchestrated by a suite of volatile cuticular hydrocarbon pheromones. 7(Z),11(Z)-Heptacosadiene is the predominant female-specific courtship pheromone of the fruit fly D. melanogaster. At amounts above 100 ng, 7(Z),11(Z)-heptacosadiene elicits wing vibrations in male D. melanogaster flies in a dose-dependent manner.{16279}
Brand:CaymanSKU:10012567 - 5 mgAvailable on backorder
The mating and social behaviors of insects are largely orchestrated by a suite of volatile cuticular hydrocarbon pheromones. 7(Z),11(Z)-Heptacosadiene is the predominant female-specific courtship pheromone of the fruit fly D. melanogaster. At amounts above 100 ng, 7(Z),11(Z)-heptacosadiene elicits wing vibrations in male D. melanogaster flies in a dose-dependent manner.{16279}
Brand:CaymanSKU:10012567 - 50 mgAvailable on backorder
Unsaturated cuticular hydrocarbons serve as pheromones in insects. In D. melanogaster, these hydrocarbons are sexually dimorphic in both their occurrence and their effects. 7(Z),11(Z)-Nonacosadiene is a cuticular pheromone in female fruit flies that stimulates male courtship behavior.{16828} The biosynthesis of this C29 diene appears to be mediated by an elongase with female-based expression.{16827}
Brand:CaymanSKU:9000314 - 1 mgAvailable on backorder
Unsaturated cuticular hydrocarbons serve as pheromones in insects. In D. melanogaster, these hydrocarbons are sexually dimorphic in both their occurrence and their effects. 7(Z),11(Z)-Nonacosadiene is a cuticular pheromone in female fruit flies that stimulates male courtship behavior.{16828} The biosynthesis of this C29 diene appears to be mediated by an elongase with female-based expression.{16827}
Brand:CaymanSKU:9000314 - 10 mgAvailable on backorder
Unsaturated cuticular hydrocarbons serve as pheromones in insects. In D. melanogaster, these hydrocarbons are sexually dimorphic in both their occurrence and their effects. 7(Z),11(Z)-Nonacosadiene is a cuticular pheromone in female fruit flies that stimulates male courtship behavior.{16828} The biosynthesis of this C29 diene appears to be mediated by an elongase with female-based expression.{16827}
Brand:CaymanSKU:9000314 - 5 mgAvailable on backorder
Unsaturated cuticular hydrocarbons serve as pheromones in insects. In D. melanogaster, these hydrocarbons are sexually dimorphic in both their occurrence and their effects. 7(Z),11(Z)-Nonacosadiene is a cuticular pheromone in female fruit flies that stimulates male courtship behavior.{16828} The biosynthesis of this C29 diene appears to be mediated by an elongase with female-based expression.{16827}
Brand:CaymanSKU:9000314 - 50 mgAvailable on backorder
Unsaturated, long-chain hydrocarbons are found on the cuticles of insects and can act as pheromones. In mature Drosophila melanogaster, certain cuticular hydrocarbons are sexually dimorphic: males synthesize 23- and 25-C monoenes and females produce 27- and 29-C dienes. Each of these lipids plays specific roles in regulating male sexual behavior, with dienes stimulating courtship.{16828} 7(Z),11(Z)-Pentacosadiene is a 25-C hydrocarbon that is found in low abundance on cuticles of mature Drosophila females.{17569} Depletion of a female-specific elongase (eloF), which leads to an increase in 7(Z),11(Z)-pentacosadiene along with a parallel decrease in 7,11-nonacosadiene, significantly reduces copulation in Drosophila.{16827} This raises the possibility that 7(Z),11(Z)-pentacosadiene may act as an anti-aphrodisiac.
Brand:CaymanSKU:9000531 - 1 mgAvailable on backorder
Unsaturated, long-chain hydrocarbons are found on the cuticles of insects and can act as pheromones. In mature Drosophila melanogaster, certain cuticular hydrocarbons are sexually dimorphic: males synthesize 23- and 25-C monoenes and females produce 27- and 29-C dienes. Each of these lipids plays specific roles in regulating male sexual behavior, with dienes stimulating courtship.{16828} 7(Z),11(Z)-Pentacosadiene is a 25-C hydrocarbon that is found in low abundance on cuticles of mature Drosophila females.{17569} Depletion of a female-specific elongase (eloF), which leads to an increase in 7(Z),11(Z)-pentacosadiene along with a parallel decrease in 7,11-nonacosadiene, significantly reduces copulation in Drosophila.{16827} This raises the possibility that 7(Z),11(Z)-pentacosadiene may act as an anti-aphrodisiac.
Brand:CaymanSKU:9000531 - 10 mgAvailable on backorder
Unsaturated, long-chain hydrocarbons are found on the cuticles of insects and can act as pheromones. In mature Drosophila melanogaster, certain cuticular hydrocarbons are sexually dimorphic: males synthesize 23- and 25-C monoenes and females produce 27- and 29-C dienes. Each of these lipids plays specific roles in regulating male sexual behavior, with dienes stimulating courtship.{16828} 7(Z),11(Z)-Pentacosadiene is a 25-C hydrocarbon that is found in low abundance on cuticles of mature Drosophila females.{17569} Depletion of a female-specific elongase (eloF), which leads to an increase in 7(Z),11(Z)-pentacosadiene along with a parallel decrease in 7,11-nonacosadiene, significantly reduces copulation in Drosophila.{16827} This raises the possibility that 7(Z),11(Z)-pentacosadiene may act as an anti-aphrodisiac.
Brand:CaymanSKU:9000531 - 5 mgAvailable on backorder
Unsaturated, long-chain hydrocarbons are found on the cuticles of insects and can act as pheromones. In mature Drosophila melanogaster, certain cuticular hydrocarbons are sexually dimorphic: males synthesize 23- and 25-C monoenes and females produce 27- and 29-C dienes. Each of these lipids plays specific roles in regulating male sexual behavior, with dienes stimulating courtship.{16828} 7(Z),11(Z)-Pentacosadiene is a 25-C hydrocarbon that is found in low abundance on cuticles of mature Drosophila females.{17569} Depletion of a female-specific elongase (eloF), which leads to an increase in 7(Z),11(Z)-pentacosadiene along with a parallel decrease in 7,11-nonacosadiene, significantly reduces copulation in Drosophila.{16827} This raises the possibility that 7(Z),11(Z)-pentacosadiene may act as an anti-aphrodisiac.
Brand:CaymanSKU:9000531 - 50 mgAvailable on backorder
740 Y-P is a peptide activator of phosphatidylinositol 3-kinase (PI3K).{37145} It binds to the p85 N- and C-terminal SH2 domains of PI3K but not to GST or the N-terminal domain of phospholipase C (PLC) in an affinity purification assay. 740 Y-P is cell-permeable and stimulates mitogenesis in serum-starved C2 cells at a concentration of 50 μg/ml. This effect is abolished by treatment with 10 μM wortmannin (Item No. 10010591), a PI3K inhibitor, indicating 740 Y-P is interacting specifically with PI3K in cells. 740 Y-P also reverses inhibition of PI3K by schisandrin B in U251 and U87 melanoma cells, inducing expression of phosphorylated mammalian target of rapamycin (p-mTOR) and matrix metalloproteinase-9 (MMP-9).{37146}
Brand:CaymanSKU:22598 -Out of stock
740 Y-P is a peptide activator of phosphatidylinositol 3-kinase (PI3K).{37145} It binds to the p85 N- and C-terminal SH2 domains of PI3K but not to GST or the N-terminal domain of phospholipase C (PLC) in an affinity purification assay. 740 Y-P is cell-permeable and stimulates mitogenesis in serum-starved C2 cells at a concentration of 50 μg/ml. This effect is abolished by treatment with 10 μM wortmannin (Item No. 10010591), a PI3K inhibitor, indicating 740 Y-P is interacting specifically with PI3K in cells. 740 Y-P also reverses inhibition of PI3K by schisandrin B in U251 and U87 melanoma cells, inducing expression of phosphorylated mammalian target of rapamycin (p-mTOR) and matrix metalloproteinase-9 (MMP-9).{37146}
Brand:CaymanSKU:22598 -Out of stock
7ACC2 is a carboxycoumarin inhibitor of monocarboxylate transporter 1 (MCT1) with an IC50 value of 10 nM for lactate uptake, an MCT1-dependent process, in SiHa human cervix carcinoma cells.{36195} It inhibits proliferation of SiHa cells in the presence of lactate in a dose-dependent manner but lacks cytotoxicity in the presence of glucose. 7ACC2 also inhibits the mitochondrial pyruvate carrier (MPC) in a concentration- and time-dependent manner in isolated tumor cell mitochondria.{46097} In vivo, 7ACC2 (3 mg/kg) increases intratumor lactate accumulation and decreases tumor size in an SiHa mouse xenograft model.
Brand:CaymanSKU:23445 - 1 mgAvailable on backorder
7ACC2 is a carboxycoumarin inhibitor of monocarboxylate transporter 1 (MCT1) with an IC50 value of 10 nM for lactate uptake, an MCT1-dependent process, in SiHa human cervix carcinoma cells.{36195} It inhibits proliferation of SiHa cells in the presence of lactate in a dose-dependent manner but lacks cytotoxicity in the presence of glucose. 7ACC2 also inhibits the mitochondrial pyruvate carrier (MPC) in a concentration- and time-dependent manner in isolated tumor cell mitochondria.{46097} In vivo, 7ACC2 (3 mg/kg) increases intratumor lactate accumulation and decreases tumor size in an SiHa mouse xenograft model.
Brand:CaymanSKU:23445 - 10 mgAvailable on backorder
7ACC2 is a carboxycoumarin inhibitor of monocarboxylate transporter 1 (MCT1) with an IC50 value of 10 nM for lactate uptake, an MCT1-dependent process, in SiHa human cervix carcinoma cells.{36195} It inhibits proliferation of SiHa cells in the presence of lactate in a dose-dependent manner but lacks cytotoxicity in the presence of glucose. 7ACC2 also inhibits the mitochondrial pyruvate carrier (MPC) in a concentration- and time-dependent manner in isolated tumor cell mitochondria.{46097} In vivo, 7ACC2 (3 mg/kg) increases intratumor lactate accumulation and decreases tumor size in an SiHa mouse xenograft model.
Brand:CaymanSKU:23445 - 25 mgAvailable on backorder
7ACC2 is a carboxycoumarin inhibitor of monocarboxylate transporter 1 (MCT1) with an IC50 value of 10 nM for lactate uptake, an MCT1-dependent process, in SiHa human cervix carcinoma cells.{36195} It inhibits proliferation of SiHa cells in the presence of lactate in a dose-dependent manner but lacks cytotoxicity in the presence of glucose. 7ACC2 also inhibits the mitochondrial pyruvate carrier (MPC) in a concentration- and time-dependent manner in isolated tumor cell mitochondria.{46097} In vivo, 7ACC2 (3 mg/kg) increases intratumor lactate accumulation and decreases tumor size in an SiHa mouse xenograft model.
Brand:CaymanSKU:23445 - 5 mgAvailable on backorder
7BIO is a derivative of indirubin (Item No. 14155) that triggers a rapid cell death process that is distinct from apoptosis and devoid of cytochrome c release or caspase activation.{31285} Furthermore, in contrast to other indirubin derivatives, 7BIO has only marginal activity against the classic indirubin targets, cyclin-dependent kinases and GSK3.{31285,22470} Instead, 7BIO inhibits FLT3 (IC50 = 0.34 µM) and the dual-specificity tyrosine phosphorylation-regulated kinases, DYRK1A and DYRK2 (IC50s = 1.9 and 1.3 µM, respectively).{31285,31284} It also inhibits Aurora B and C kinases with IC50 values of 4.6 and 0.7 µM, respectively.{31285,31283}
Brand:CaymanSKU:19619 -Available on backorder
7BIO is a derivative of indirubin (Item No. 14155) that triggers a rapid cell death process that is distinct from apoptosis and devoid of cytochrome c release or caspase activation.{31285} Furthermore, in contrast to other indirubin derivatives, 7BIO has only marginal activity against the classic indirubin targets, cyclin-dependent kinases and GSK3.{31285,22470} Instead, 7BIO inhibits FLT3 (IC50 = 0.34 µM) and the dual-specificity tyrosine phosphorylation-regulated kinases, DYRK1A and DYRK2 (IC50s = 1.9 and 1.3 µM, respectively).{31285,31284} It also inhibits Aurora B and C kinases with IC50 values of 4.6 and 0.7 µM, respectively.{31285,31283}
Brand:CaymanSKU:19619 -Available on backorder
7Z,10Z,13Z,16Z-Docosatetraenoic acid is a naturally occurring polyunsaturated fatty acid (PUFA) formed through a 2-carbon chain elongation of arachidonic acid. It is present in the adrenal glands, brain, testis, and kidney.{1288} Although there is trace metabolism of adrenic acid in the forebrain, the renal medulla is the only tissue which readily metabolizes the acid through cyclooxygenase activity.{1288,2047} The primary metabolite of 7Z,10Z,13Z,16Z-docosatetraenoic acid in the rabbit kidney is 1a,1b-dihomo prostaglandin E2.{1288}
Brand:CaymanSKU:90300 - 10 mgAvailable on backorder
7Z,10Z,13Z,16Z-Docosatetraenoic acid is a naturally occurring polyunsaturated fatty acid (PUFA) formed through a 2-carbon chain elongation of arachidonic acid. It is present in the adrenal glands, brain, testis, and kidney.{1288} Although there is trace metabolism of adrenic acid in the forebrain, the renal medulla is the only tissue which readily metabolizes the acid through cyclooxygenase activity.{1288,2047} The primary metabolite of 7Z,10Z,13Z,16Z-docosatetraenoic acid in the rabbit kidney is 1a,1b-dihomo prostaglandin E2.{1288}
Brand:CaymanSKU:90300 - 100 mgAvailable on backorder
7Z,10Z,13Z,16Z-Docosatetraenoic acid is a naturally occurring polyunsaturated fatty acid (PUFA) formed through a 2-carbon chain elongation of arachidonic acid. It is present in the adrenal glands, brain, testis, and kidney.{1288} Although there is trace metabolism of adrenic acid in the forebrain, the renal medulla is the only tissue which readily metabolizes the acid through cyclooxygenase activity.{1288,2047} The primary metabolite of 7Z,10Z,13Z,16Z-docosatetraenoic acid in the rabbit kidney is 1a,1b-dihomo prostaglandin E2.{1288}
Brand:CaymanSKU:90300 - 25 mgAvailable on backorder
7Z,10Z,13Z,16Z-Docosatetraenoic acid is a naturally occurring polyunsaturated fatty acid (PUFA) formed through a 2-carbon chain elongation of arachidonic acid. It is present in the adrenal glands, brain, testis, and kidney.{1288} Although there is trace metabolism of adrenic acid in the forebrain, the renal medulla is the only tissue which readily metabolizes the acid through cyclooxygenase activity.{1288,2047} The primary metabolite of 7Z,10Z,13Z,16Z-docosatetraenoic acid in the rabbit kidney is 1a,1b-dihomo prostaglandin E2.{1288}
Brand:CaymanSKU:90300 - 50 mgAvailable on backorder
7α-hydroxy Cholesterol is an oxysterol and a precursor in the biosynthesis of the bile acids cholic acid (CA; Item No. 20250) and chenodeoxycholic acid (CDCA; Item No. 10011286).{42274,48225} It is formed via the oxidation of cholesterol (Item No. 9003100) by cholesterol 7α-hydroxylase/CYP7A1 in rat liver microsomes.{42274} 7α-hydroxy Cholesterol (40 µM) increases levels of the adhesion molecules ICAM-1, VCAM-1, and E-selectin in human umbilical vein endothelial cells (HUVECs).{60007} It increases secretion of chemokine (C-C motif) ligand 2 (CCL2) and matrix metalloproteinase-9 (MMP-9) in serum-deprived THP-1 cells when used at a concentration of 5 µg/ml.{42273} 7α-hydroxy Cholesterol has been found in macrophages isolated from atherosclerotic lesions in rabbits fed a high-cholesterol diet.{60008}
Brand:CaymanSKU:20098 -Available on backorder
7α-hydroxy Cholesterol is an oxysterol and a precursor in the biosynthesis of the bile acids cholic acid (CA; Item No. 20250) and chenodeoxycholic acid (CDCA; Item No. 10011286).{42274,48225} It is formed via the oxidation of cholesterol (Item No. 9003100) by cholesterol 7α-hydroxylase/CYP7A1 in rat liver microsomes.{42274} 7α-hydroxy Cholesterol (40 µM) increases levels of the adhesion molecules ICAM-1, VCAM-1, and E-selectin in human umbilical vein endothelial cells (HUVECs).{60007} It increases secretion of chemokine (C-C motif) ligand 2 (CCL2) and matrix metalloproteinase-9 (MMP-9) in serum-deprived THP-1 cells when used at a concentration of 5 µg/ml.{42273} 7α-hydroxy Cholesterol has been found in macrophages isolated from atherosclerotic lesions in rabbits fed a high-cholesterol diet.{60008}
Brand:CaymanSKU:20098 -Available on backorder
7α-hydroxy Cholesterol is an oxysterol and a precursor in the biosynthesis of the bile acids cholic acid (CA; Item No. 20250) and chenodeoxycholic acid (CDCA; Item No. 10011286).{42274,48225} It is formed via the oxidation of cholesterol (Item No. 9003100) by cholesterol 7α-hydroxylase/CYP7A1 in rat liver microsomes.{42274} 7α-hydroxy Cholesterol (40 µM) increases levels of the adhesion molecules ICAM-1, VCAM-1, and E-selectin in human umbilical vein endothelial cells (HUVECs).{60007} It increases secretion of chemokine (C-C motif) ligand 2 (CCL2) and matrix metalloproteinase-9 (MMP-9) in serum-deprived THP-1 cells when used at a concentration of 5 µg/ml.{42273} 7α-hydroxy Cholesterol has been found in macrophages isolated from atherosclerotic lesions in rabbits fed a high-cholesterol diet.{60008}
Brand:CaymanSKU:20098 -Available on backorder
7α-hydroxy Cholesterol is an oxysterol and a precursor in the biosynthesis of the bile acids cholic acid (CA; Item No. 20250) and chenodeoxycholic acid (CDCA; Item No. 10011286).{42274,48225} It is formed via the oxidation of cholesterol (Item No. 9003100) by cholesterol 7α-hydroxylase/CYP7A1 in rat liver microsomes.{42274} 7α-hydroxy Cholesterol (40 µM) increases levels of the adhesion molecules ICAM-1, VCAM-1, and E-selectin in human umbilical vein endothelial cells (HUVECs).{60007} It increases secretion of chemokine (C-C motif) ligand 2 (CCL2) and matrix metalloproteinase-9 (MMP-9) in serum-deprived THP-1 cells when used at a concentration of 5 µg/ml.{42273} 7α-hydroxy Cholesterol has been found in macrophages isolated from atherosclerotic lesions in rabbits fed a high-cholesterol diet.{60008}
Brand:CaymanSKU:20098 -Available on backorder
7α-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 7α-hydroxy cholesterol (Item No. 20098) by GC- or LC-MS. 7α-hydroxy Cholesterol is an oxysterol and a precursor in the biosynthesis of the bile acids cholic acid (CA; Item No. 20250) and chenodeoxycholic acid (CDCA; Item No. 10011286).{42274,48225} It is formed via the oxidation of cholesterol (Item No. 9003100) by cholesterol 7α-hydroxylase/CYP7A1 in rat liver microsomes.{42274} 7α-hydroxy Cholesterol (40 µM) increases levels of the adhesion molecules ICAM-1, VCAM-1, and E-selectin in human umbilical vein endothelial cells (HUVECs).{60007} It increases secretion of chemokine (C-C motif) ligand 2 (CCL2) and matrix metalloproteinase-9 (MMP-9) in serum-deprived THP-1 cells when used at a concentration of 5 µg/ml.{42273} 7α-hydroxy Cholesterol has been found in macrophages isolated from atherosclerotic lesions in rabbits fed a high-cholesterol diet.{60008}
Brand:CaymanSKU:25547 - 1 mgAvailable on backorder
7α-hydroxy-4-Cholesten-3-one is a metabolite of 7α-hydroxy cholesterol and an intermediate in the biosynthesis of bile acids.{37690} Plasma levels of 7α-hydroxy-4-cholesten-3-one positively correlate with the rate of bile acid synthesis in humans and are increased in patients following ileal resection.{37691}
Brand:CaymanSKU:25442 - 1 mgAvailable on backorder
GPR183 (also known as Epstein-Barr virus-induced gene 2) is an orphan G protein-coupled receptor (GPCR) that is highly expressed in spleen and is required for humoral immune responses, including B cell migration and T cell-dependent antibody production.{19918,19919} 7α,25-dihydroxy Cholesterol (7α,25-DHC) is a potent agonist of GPR183 that induces specific activation of the receptor with an EC50 value of 50 nM (Kd = 450 pM).{19918,19919} At concentrations below 3 μM, it does not show any appreciable binding activity when tested against eight different nuclear hormone receptors including LXR and thirty-one different G protein-coupled receptors in a panel of reporter gene assays.{19919} 7α,25-DHC can act as a potent chemokine, affecting migration of immune cells expressing GPR183 both in vitro (EC50 = 500 pM) and in vivo.{19918,19919}
Brand:CaymanSKU:11032 - 1 mgAvailable on backorder
GPR183 (also known as Epstein-Barr virus-induced gene 2) is an orphan G protein-coupled receptor (GPCR) that is highly expressed in spleen and is required for humoral immune responses, including B cell migration and T cell-dependent antibody production.{19918,19919} 7α,25-dihydroxy Cholesterol (7α,25-DHC) is a potent agonist of GPR183 that induces specific activation of the receptor with an EC50 value of 50 nM (Kd = 450 pM).{19918,19919} At concentrations below 3 μM, it does not show any appreciable binding activity when tested against eight different nuclear hormone receptors including LXR and thirty-one different G protein-coupled receptors in a panel of reporter gene assays.{19919} 7α,25-DHC can act as a potent chemokine, affecting migration of immune cells expressing GPR183 both in vitro (EC50 = 500 pM) and in vivo.{19918,19919}
Brand:CaymanSKU:11032 - 10 mgAvailable on backorder
GPR183 (also known as Epstein-Barr virus-induced gene 2) is an orphan G protein-coupled receptor (GPCR) that is highly expressed in spleen and is required for humoral immune responses, including B cell migration and T cell-dependent antibody production.{19918,19919} 7α,25-dihydroxy Cholesterol (7α,25-DHC) is a potent agonist of GPR183 that induces specific activation of the receptor with an EC50 value of 50 nM (Kd = 450 pM).{19918,19919} At concentrations below 3 μM, it does not show any appreciable binding activity when tested against eight different nuclear hormone receptors including LXR and thirty-one different G protein-coupled receptors in a panel of reporter gene assays.{19919} 7α,25-DHC can act as a potent chemokine, affecting migration of immune cells expressing GPR183 both in vitro (EC50 = 500 pM) and in vivo.{19918,19919}
Brand:CaymanSKU:11032 - 5 mgAvailable on backorder
7β-hydroxy Cholesterol is an oxysterol formed by enzymatic and non-enzymatic oxidation of cholesterol.{36765} It is the primary oxysterol found in LDL and induces apoptosis and cell death of human umbilical vein endothelial cells (HUVECs) in vitro in a concentration-dependent manner. Increased plasma levels of 7β-hydroxy cholesterol positively correlate with mortality in coronary heart disease in human males.{36766}
Brand:CaymanSKU:20099 -Available on backorder
7β-hydroxy Cholesterol is an oxysterol formed by enzymatic and non-enzymatic oxidation of cholesterol.{36765} It is the primary oxysterol found in LDL and induces apoptosis and cell death of human umbilical vein endothelial cells (HUVECs) in vitro in a concentration-dependent manner. Increased plasma levels of 7β-hydroxy cholesterol positively correlate with mortality in coronary heart disease in human males.{36766}
Brand:CaymanSKU:20099 -Available on backorder
7β-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 7β-hydroxy cholesterol by GC- or LC-MS. 7β-hydroxy Cholesterol is an oxysterol formed by enzymatic and non-enzymatic oxidation of cholesterol.{36765} It is the primary oxysterol found in LDL and induces apoptosis and cell death of human umbilical vein endothelial cells (HUVECs) in vitro in a concentration-dependent manner. Increased plasma levels of 7β-hydroxy cholesterol positively correlate with mortality in coronary heart disease in human males.{36766}
Brand:CaymanSKU:25548 - 1 mgAvailable on backorder
7β-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 7β-hydroxy cholesterol by GC- or LC-MS. 7β-hydroxy Cholesterol is an oxysterol formed by enzymatic and non-enzymatic oxidation of cholesterol.{36765} It is the primary oxysterol found in LDL and induces apoptosis and cell death of human umbilical vein endothelial cells (HUVECs) in vitro in a concentration-dependent manner. Increased plasma levels of 7β-hydroxy cholesterol positively correlate with mortality in coronary heart disease in human males.{36766}
Brand:CaymanSKU:25548 - 500 µgAvailable on backorder
7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt.{33003} It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 µM. It increases IL-17A production in Th17-polarized isolated human naïve CD4+ T cells when used at a concentration of 300 nM. 7β,27-dihydroxy Cholesterol (60 mg/kg) increases IL-17A production in isolated mouse γδ T cells stimulated with 12-myristate 13-acetate (PMA; Item No. 10008014) and ionomycin (Item Nos. 10004974 | 11932).
Brand:CaymanSKU:20102 -Available on backorder
7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt.{33003} It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 µM. It increases IL-17A production in Th17-polarized isolated human naïve CD4+ T cells when used at a concentration of 300 nM. 7β,27-dihydroxy Cholesterol (60 mg/kg) increases IL-17A production in isolated mouse γδ T cells stimulated with 12-myristate 13-acetate (PMA; Item No. 10008014) and ionomycin (Item Nos. 10004974 | 11932).
Brand:CaymanSKU:20102 -Available on backorder
8-(3-Chlorostyryl)caffeine (CSC) is an adenosine A2 receptor antagonist (Ki = 54 nM).{53268} It is selective for adenosine A2 over A1 receptors (Ki = 28 µM). CSC reverses locomotor depression induced by the adenosine A2A agonist APEC in mice (ED50 = 16 µg/kg, i.p.). It increases locomotion in mice when administered at a dose of 5 mg/kg. CSC (5 mg/kg) reverses the shortening of the rotational motor response and increases in striatal adenosine A2 receptor levels induced by L-DOPA (Item No. 13248) in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{53269} It also inhibits monoamine oxidase B (MAO-B; Ki = 100 nM) and reduces MAO-B activity in brain mitochondrial preparations from wild-type and A2A-/- mice.{53270}
Brand:CaymanSKU:29704 - 10 mgAvailable on backorder
8-(3-Chlorostyryl)caffeine (CSC) is an adenosine A2 receptor antagonist (Ki = 54 nM).{53268} It is selective for adenosine A2 over A1 receptors (Ki = 28 µM). CSC reverses locomotor depression induced by the adenosine A2A agonist APEC in mice (ED50 = 16 µg/kg, i.p.). It increases locomotion in mice when administered at a dose of 5 mg/kg. CSC (5 mg/kg) reverses the shortening of the rotational motor response and increases in striatal adenosine A2 receptor levels induced by L-DOPA (Item No. 13248) in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{53269} It also inhibits monoamine oxidase B (MAO-B; Ki = 100 nM) and reduces MAO-B activity in brain mitochondrial preparations from wild-type and A2A-/- mice.{53270}
Brand:CaymanSKU:29704 - 25 mgAvailable on backorder
8-(3-Chlorostyryl)caffeine (CSC) is an adenosine A2 receptor antagonist (Ki = 54 nM).{53268} It is selective for adenosine A2 over A1 receptors (Ki = 28 µM). CSC reverses locomotor depression induced by the adenosine A2A agonist APEC in mice (ED50 = 16 µg/kg, i.p.). It increases locomotion in mice when administered at a dose of 5 mg/kg. CSC (5 mg/kg) reverses the shortening of the rotational motor response and increases in striatal adenosine A2 receptor levels induced by L-DOPA (Item No. 13248) in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{53269} It also inhibits monoamine oxidase B (MAO-B; Ki = 100 nM) and reduces MAO-B activity in brain mitochondrial preparations from wild-type and A2A-/- mice.{53270}
Brand:CaymanSKU:29704 - 50 mgAvailable on backorder
8-Aminoclonazolam (Item No. 27247) is an analytical reference standard categorized as a benzodiazepine metabolite.{40539} It is a metabolite of clonazolam. This product is intended for research and forensic applications.
Brand:CaymanSKU:27247 - 1 mgAvailable on backorder
8-Aminoclonazolam (Item No. 27247) is an analytical reference standard categorized as a benzodiazepine metabolite.{40539} It is a metabolite of clonazolam. This product is intended for research and forensic applications.
Brand:CaymanSKU:27247 - 5 mgAvailable on backorder
8-Aminopyrene-1,3,6-trisulfonic acid (APTS) is an anionic fluorescent dye with excitation/emission spectra of 425/503 nm, respectively.{37198} It forms a ground state complex with viologen-type quenchers, inducing a red-shift in the absorbance spectrum from 425 to 464 nm. APTS is pH insensitive, with the emission maximum remaining constant over the pH range of 4-10. It can be used in solution or immobilized through attachment of an aldehyde functionalized monomer by reductive amination without significantly changing fluorescence intensity. APTS has been used as a reporter for glucose sensing and for the detection of other saccharides.{37198,37199}
Brand:CaymanSKU:23098 - 1 mgAvailable on backorder
8-Aminopyrene-1,3,6-trisulfonic acid (APTS) is an anionic fluorescent dye with excitation/emission spectra of 425/503 nm, respectively.{37198} It forms a ground state complex with viologen-type quenchers, inducing a red-shift in the absorbance spectrum from 425 to 464 nm. APTS is pH insensitive, with the emission maximum remaining constant over the pH range of 4-10. It can be used in solution or immobilized through attachment of an aldehyde functionalized monomer by reductive amination without significantly changing fluorescence intensity. APTS has been used as a reporter for glucose sensing and for the detection of other saccharides.{37198,37199}
Brand:CaymanSKU:23098 - 10 mgAvailable on backorder
8-Aminopyrene-1,3,6-trisulfonic acid (APTS) is an anionic fluorescent dye with excitation/emission spectra of 425/503 nm, respectively.{37198} It forms a ground state complex with viologen-type quenchers, inducing a red-shift in the absorbance spectrum from 425 to 464 nm. APTS is pH insensitive, with the emission maximum remaining constant over the pH range of 4-10. It can be used in solution or immobilized through attachment of an aldehyde functionalized monomer by reductive amination without significantly changing fluorescence intensity. APTS has been used as a reporter for glucose sensing and for the detection of other saccharides.{37198,37199}
Brand:CaymanSKU:23098 - 5 mgAvailable on backorder
8-bromo-Cyclic AMP is a brominated derivative of cAMP that remains long-acting due to its resistance to degradation by cAMP phosphodiesterase.{26217,26218} It can activate cAMP-dependent protein kinase, inhibiting growth, decreasing proliferation, increasing differentiation, and inducing apoptosis of cancer cells.{26218}
Brand:CaymanSKU:-Available on backorder
8-bromo-Cyclic AMP is a brominated derivative of cAMP that remains long-acting due to its resistance to degradation by cAMP phosphodiesterase.{26217,26218} It can activate cAMP-dependent protein kinase, inhibiting growth, decreasing proliferation, increasing differentiation, and inducing apoptosis of cancer cells.{26218}
Brand:CaymanSKU:-Available on backorder
8-bromo-Cyclic AMP is a brominated derivative of cAMP that remains long-acting due to its resistance to degradation by cAMP phosphodiesterase.{26217,26218} It can activate cAMP-dependent protein kinase, inhibiting growth, decreasing proliferation, increasing differentiation, and inducing apoptosis of cancer cells.{26218}
Brand:CaymanSKU:-Available on backorder
8-bromo-Cyclic AMP is a brominated derivative of cAMP that remains long-acting due to its resistance to degradation by cAMP phosphodiesterase.{26217,26218} It can activate cAMP-dependent protein kinase, inhibiting growth, decreasing proliferation, increasing differentiation, and inducing apoptosis of cancer cells.{26218}
Brand:CaymanSKU:-Available on backorder
8-bromo-Cyclic AMP (8-bromo-cAMP) is a cell-permeable analog of cAMP that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM.{22886} It activates cyclic-GMP-dependent protein kinase with 100-fold reduced potency (Ka = 5.8 μM).{22886} 8-bromo-cAMP is more stable to hydrolysis and has increased membrane permeability compared to unmodified cAMP.{22886}
Brand:CaymanSKU:- 8-bromo-Cyclic AMP (8-bromo-cAMP) is a cell-permeable analog of cAMP that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM.{22886} It activates cyclic-GMP-dependent protein kinase with 100-fold reduced potency (Ka = 5.8 μM).{22886} 8-bromo-cAMP is more stable to hydrolysis and has increased membrane permeability compared to unmodified cAMP.{22886}
Brand:CaymanSKU:- 8-bromo-Cyclic AMP (8-bromo-cAMP) is a cell-permeable analog of cAMP that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM.{22886} It activates cyclic-GMP-dependent protein kinase with 100-fold reduced potency (Ka = 5.8 μM).{22886} 8-bromo-cAMP is more stable to hydrolysis and has increased membrane permeability compared to unmodified cAMP.{22886}
Brand:CaymanSKU:-
8-bromo-Cyclic GMP (8-bromo-cGMP) is a cell-permeable analog of cGMP that exhibits greater resistance to hydrolysis by phosphodiesterases than its parent compound. It preferentially activates cGMP-dependent protein kinase.{25938} At 1 µM-0.1 mM, 8-bromo-cGMP can inhibit acetylcholine-induced increases in intracellular calcium concentrations.{25937}
Brand:CaymanSKU:- 8-bromo-Cyclic GMP (8-bromo-cGMP) is a cell-permeable analog of cGMP that exhibits greater resistance to hydrolysis by phosphodiesterases than its parent compound. It preferentially activates cGMP-dependent protein kinase.{25938} At 1 µM-0.1 mM, 8-bromo-cGMP can inhibit acetylcholine-induced increases in intracellular calcium concentrations.{25937}
Brand:CaymanSKU:- 8-bromo-Cyclic GMP (8-bromo-cGMP) is a cell-permeable analog of cGMP that exhibits greater resistance to hydrolysis by phosphodiesterases than its parent compound. It preferentially activates cGMP-dependent protein kinase.{25938} At 1 µM-0.1 mM, 8-bromo-cGMP can inhibit acetylcholine-induced increases in intracellular calcium concentrations.{25937}
Brand:CaymanSKU:- 8-bromo-Cyclic GMP (8-bromo-cGMP) is a cell-permeable analog of cGMP that exhibits greater resistance to hydrolysis by phosphodiesterases than its parent compound. It preferentially activates cGMP-dependent protein kinase.{25938} At 1 µM-0.1 mM, 8-bromo-cGMP can inhibit acetylcholine-induced increases in intracellular calcium concentrations.{25937}
Brand:CaymanSKU:-
8-Bromoguanosine is a brominated derivative of guanosine. Purine nucleobases with bromine at position eight are known to preferentially adopt the syn conformation as nucleosides and, thus, can be used to reduce the conformational heterogeneity of RNA to potentially enhance its function.{29473} It is reported to activate lymphocytes through an intracellular mechanism to exert immunostimulatory effects.{29472,29471}
Brand:CaymanSKU:-Available on backorder
8-Bromoguanosine is a brominated derivative of guanosine. Purine nucleobases with bromine at position eight are known to preferentially adopt the syn conformation as nucleosides and, thus, can be used to reduce the conformational heterogeneity of RNA to potentially enhance its function.{29473} It is reported to activate lymphocytes through an intracellular mechanism to exert immunostimulatory effects.{29472,29471}
Brand:CaymanSKU:-Available on backorder
8-Bromoguanosine is a brominated derivative of guanosine. Purine nucleobases with bromine at position eight are known to preferentially adopt the syn conformation as nucleosides and, thus, can be used to reduce the conformational heterogeneity of RNA to potentially enhance its function.{29473} It is reported to activate lymphocytes through an intracellular mechanism to exert immunostimulatory effects.{29472,29471}
Brand:CaymanSKU:-Available on backorder
8-Bromoguanosine is a brominated derivative of guanosine. Purine nucleobases with bromine at position eight are known to preferentially adopt the syn conformation as nucleosides and, thus, can be used to reduce the conformational heterogeneity of RNA to potentially enhance its function.{29473} It is reported to activate lymphocytes through an intracellular mechanism to exert immunostimulatory effects.{29472,29471}
Brand:CaymanSKU:-Available on backorder