Cayman
Showing 7051–7200 of 45550 results
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6-MNA is a competitive, non-selective COX inhibitor.{1286,1364,1791} The Ki values for ovine COX-1 and -2 are 21 and 19 µM, respectively.{1364} The IC50 values are 70 and 20 µM for human recombinant COX-1 and -2, respectively.{1286}
Brand:CaymanSKU:70620 - 5 mgAvailable on backorder
6-MNA is a competitive, non-selective COX inhibitor.{1286,1364,1791} The Ki values for ovine COX-1 and -2 are 21 and 19 µM, respectively.{1364} The IC50 values are 70 and 20 µM for human recombinant COX-1 and -2, respectively.{1286}
Brand:CaymanSKU:70620 - 50 mgAvailable on backorder
6-Methylsulfinylhexyl isothiocyanate (6-MSITC) is an isothiocyanate that has been found in wasabi (W. japonica) and has diverse biological activities.{31411,31409,54330,31410,54331} It inhibits nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at a concentration of 5 µM.{31411} It inhibits aggregation of isolated human platelets induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607; IC50 = 21.9 µM).{31409} 6-MSITC reduces cell survival in a panel of breast, brain, colon, lung, ovarian, renal, and prostate cancer cell lines (mean IC50 = 43.7 µM).{54330} In vivo, 6-MSITC (5 mg/kg twice weekly) reduces apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{31410} 6-MSITC also reduces the number of lung metastases in a B16/F10 murine melanoma model.{54331}
Brand:CaymanSKU:19638 -Available on backorder
6-Methylsulfinylhexyl isothiocyanate (6-MSITC) is an isothiocyanate that has been found in wasabi (W. japonica) and has diverse biological activities.{31411,31409,54330,31410,54331} It inhibits nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at a concentration of 5 µM.{31411} It inhibits aggregation of isolated human platelets induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607; IC50 = 21.9 µM).{31409} 6-MSITC reduces cell survival in a panel of breast, brain, colon, lung, ovarian, renal, and prostate cancer cell lines (mean IC50 = 43.7 µM).{54330} In vivo, 6-MSITC (5 mg/kg twice weekly) reduces apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{31410} 6-MSITC also reduces the number of lung metastases in a B16/F10 murine melanoma model.{54331}
Brand:CaymanSKU:19638 -Available on backorder
6-Methylsulfinylhexyl isothiocyanate (6-MSITC) is an isothiocyanate that has been found in wasabi (W. japonica) and has diverse biological activities.{31411,31409,54330,31410,54331} It inhibits nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at a concentration of 5 µM.{31411} It inhibits aggregation of isolated human platelets induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607; IC50 = 21.9 µM).{31409} 6-MSITC reduces cell survival in a panel of breast, brain, colon, lung, ovarian, renal, and prostate cancer cell lines (mean IC50 = 43.7 µM).{54330} In vivo, 6-MSITC (5 mg/kg twice weekly) reduces apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{31410} 6-MSITC also reduces the number of lung metastases in a B16/F10 murine melanoma model.{54331}
Brand:CaymanSKU:19638 -Available on backorder
6-Methylsulfinylhexyl isothiocyanate (6-MSITC) is an isothiocyanate that has been found in wasabi (W. japonica) and has diverse biological activities.{31411,31409,54330,31410,54331} It inhibits nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at a concentration of 5 µM.{31411} It inhibits aggregation of isolated human platelets induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607; IC50 = 21.9 µM).{31409} 6-MSITC reduces cell survival in a panel of breast, brain, colon, lung, ovarian, renal, and prostate cancer cell lines (mean IC50 = 43.7 µM).{54330} In vivo, 6-MSITC (5 mg/kg twice weekly) reduces apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{31410} 6-MSITC also reduces the number of lung metastases in a B16/F10 murine melanoma model.{54331}
Brand:CaymanSKU:19638 -Available on backorder
6-NBDG is a non-hydrolyzable fluorescent glucose analog that is used to monitor glucose uptake and transport in living cells.{33229,33230,33231} 6-NBDG has been validated as a probe for the glucose transporter GLUT1 in cells.{33228} The fluorophore NBD displays excitation/emission maxima of 465/535 nm.
Brand:CaymanSKU:- 6-NBDG is a non-hydrolyzable fluorescent glucose analog that is used to monitor glucose uptake and transport in living cells.{33229,33230,33231} 6-NBDG has been validated as a probe for the glucose transporter GLUT1 in cells.{33228} The fluorophore NBD displays excitation/emission maxima of 465/535 nm.
Brand:CaymanSKU:- 6-NBDG is a non-hydrolyzable fluorescent glucose analog that is used to monitor glucose uptake and transport in living cells.{33229,33230,33231} 6-NBDG has been validated as a probe for the glucose transporter GLUT1 in cells.{33228} The fluorophore NBD displays excitation/emission maxima of 465/535 nm.
Brand:CaymanSKU:-
6-Nitroveratraldehyde is a photolabile H+-donor that releases acid when excited at 405 nm.{36196} It has been used for fluorescence imaging, in conjunction with the pH sensitive fluorescent probe cSNARF1, to study nuclear proton dynamics, acid venting from cancer cells, and hemoglobin-restricted diffusion in the cytoplasm of red blood cells.{36196,36197,36198} 6-Nitroveratraldehyde has also been used as a precursor for [18F]fluoride displacement reactions in the synthesis of NCA 6-[18F]fluoro-L-dopa that is used in positron emission tomography (PET) studies of dopaminergic systems.{36199}
Brand:CaymanSKU:23364 - 10 gAvailable on backorder
6-Nitroveratraldehyde is a photolabile H+-donor that releases acid when excited at 405 nm.{36196} It has been used for fluorescence imaging, in conjunction with the pH sensitive fluorescent probe cSNARF1, to study nuclear proton dynamics, acid venting from cancer cells, and hemoglobin-restricted diffusion in the cytoplasm of red blood cells.{36196,36197,36198} 6-Nitroveratraldehyde has also been used as a precursor for [18F]fluoride displacement reactions in the synthesis of NCA 6-[18F]fluoro-L-dopa that is used in positron emission tomography (PET) studies of dopaminergic systems.{36199}
Brand:CaymanSKU:23364 - 25 gAvailable on backorder
6-Nitroveratraldehyde is a photolabile H+-donor that releases acid when excited at 405 nm.{36196} It has been used for fluorescence imaging, in conjunction with the pH sensitive fluorescent probe cSNARF1, to study nuclear proton dynamics, acid venting from cancer cells, and hemoglobin-restricted diffusion in the cytoplasm of red blood cells.{36196,36197,36198} 6-Nitroveratraldehyde has also been used as a precursor for [18F]fluoride displacement reactions in the synthesis of NCA 6-[18F]fluoro-L-dopa that is used in positron emission tomography (PET) studies of dopaminergic systems.{36199}
Brand:CaymanSKU:23364 - 5 gAvailable on backorder
6-Nitroveratraldehyde is a photolabile H+-donor that releases acid when excited at 405 nm.{36196} It has been used for fluorescence imaging, in conjunction with the pH sensitive fluorescent probe cSNARF1, to study nuclear proton dynamics, acid venting from cancer cells, and hemoglobin-restricted diffusion in the cytoplasm of red blood cells.{36196,36197,36198} 6-Nitroveratraldehyde has also been used as a precursor for [18F]fluoride displacement reactions in the synthesis of NCA 6-[18F]fluoro-L-dopa that is used in positron emission tomography (PET) studies of dopaminergic systems.{36199}
Brand:CaymanSKU:23364 - 50 gAvailable on backorder
6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil (Item No. 13245).{42676} It is formed through dealkylation by the cytochrome P450 (CYP) isoform CYP2D6.{42677} It inhibits human ether a go-go (hERG) channels (IC50 = 1.5 µM in HEK293 cells expressing hERG).{42676}
Brand:CaymanSKU:27175 - 1 mgAvailable on backorder
6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil (Item No. 13245).{42676} It is formed through dealkylation by the cytochrome P450 (CYP) isoform CYP2D6.{42677} It inhibits human ether a go-go (hERG) channels (IC50 = 1.5 µM in HEK293 cells expressing hERG).{42676}
Brand:CaymanSKU:27175 - 5 mgAvailable on backorder
6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil (Item No. 13245).{42676} It is formed through dealkylation by the cytochrome P450 (CYP) isoform CYP2D6.{42677} It inhibits human ether a go-go (hERG) channels (IC50 = 1.5 µM in HEK293 cells expressing hERG).{42676}
Brand:CaymanSKU:27175 - 500 µgAvailable on backorder
6-O-Sulfo-β-cyclodextrin is a sulfated cyclodextrin.{56041} It has been used for the chiral separation of nadolol racemates by capillary electrophoresis.
Brand:CaymanSKU:30168 - 100 mgAvailable on backorder
6-O-Sulfo-β-cyclodextrin is a sulfated cyclodextrin.{56041} It has been used for the chiral separation of nadolol racemates by capillary electrophoresis.
Brand:CaymanSKU:30168 - 250 mgAvailable on backorder
6-O-Sulfo-β-cyclodextrin is a sulfated cyclodextrin.{56041} It has been used for the chiral separation of nadolol racemates by capillary electrophoresis.
Brand:CaymanSKU:30168 - 50 mgAvailable on backorder
GPR84 is a Gαi protein-coupled receptor that is activated by medium-chain free fatty acids, but only at micromolar concentrations.{27421} GPR84 is expressed in leukocytes and its expression is further induced by LPS.{27421,29190} 6-OAU is a synthetic agonist for GPR84 (EC50 = 512 nM).{29190} It has insignificant actions at a panel of 69 other receptors, channels, or transporters.{29190} 6-OAU promotes chemotaxis in human neutrophils (EC50 = 318 nM) and amplifies TNF-α production by LPS-treated U937 macrophages.{29190} In rats, 6-OAU (1 mg/ml) drives the recruitment of neutrophils and macrophages when injected into a subcutaneous air pouch and raises serum levels of CXCL1 (growth-regulated α protein) when delivered intravenously.{29190}
Brand:CaymanSKU:-Available on backorder
GPR84 is a Gαi protein-coupled receptor that is activated by medium-chain free fatty acids, but only at micromolar concentrations.{27421} GPR84 is expressed in leukocytes and its expression is further induced by LPS.{27421,29190} 6-OAU is a synthetic agonist for GPR84 (EC50 = 512 nM).{29190} It has insignificant actions at a panel of 69 other receptors, channels, or transporters.{29190} 6-OAU promotes chemotaxis in human neutrophils (EC50 = 318 nM) and amplifies TNF-α production by LPS-treated U937 macrophages.{29190} In rats, 6-OAU (1 mg/ml) drives the recruitment of neutrophils and macrophages when injected into a subcutaneous air pouch and raises serum levels of CXCL1 (growth-regulated α protein) when delivered intravenously.{29190}
Brand:CaymanSKU:-Available on backorder
GPR84 is a Gαi protein-coupled receptor that is activated by medium-chain free fatty acids, but only at micromolar concentrations.{27421} GPR84 is expressed in leukocytes and its expression is further induced by LPS.{27421,29190} 6-OAU is a synthetic agonist for GPR84 (EC50 = 512 nM).{29190} It has insignificant actions at a panel of 69 other receptors, channels, or transporters.{29190} 6-OAU promotes chemotaxis in human neutrophils (EC50 = 318 nM) and amplifies TNF-α production by LPS-treated U937 macrophages.{29190} In rats, 6-OAU (1 mg/ml) drives the recruitment of neutrophils and macrophages when injected into a subcutaneous air pouch and raises serum levels of CXCL1 (growth-regulated α protein) when delivered intravenously.{29190}
Brand:CaymanSKU:-Available on backorder
6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson’s disease in rodents.{37722} It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively.{37727} Intracisternal administration of 6-OHDA (200 μg) decreases dopamine (Item No. 21992) and norepinephrine (Item No. 16673) levels in rat brain.{37726} It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 μM.{37723,37724} 6-OHDA (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB.{37724,37725}
Brand:CaymanSKU:25330 - 1 gAvailable on backorder
6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson’s disease in rodents.{37722} It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively.{37727} Intracisternal administration of 6-OHDA (200 μg) decreases dopamine (Item No. 21992) and norepinephrine (Item No. 16673) levels in rat brain.{37726} It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 μM.{37723,37724} 6-OHDA (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB.{37724,37725}
Brand:CaymanSKU:25330 - 250 mgAvailable on backorder
6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson’s disease in rodents.{37722} It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively.{37727} Intracisternal administration of 6-OHDA (200 μg) decreases dopamine (Item No. 21992) and norepinephrine (Item No. 16673) levels in rat brain.{37726} It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 μM.{37723,37724} 6-OHDA (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB.{37724,37725}
Brand:CaymanSKU:25330 - 50 mgAvailable on backorder
6-Paradol is a phenolic ketone that has been found in ginger (Z. officinale) and has diverse biological activities, including antioxidant, anti-inflammatory, and anti-hyperglycemic properties.{50301,50302,50303} It inhibits hydrogen peroxide-induced oxidation of cell-free calf thymus DNA when used at a concentration of 100 μM.{50301} In vitro, 6-paradol (10 μg/ml) inhibits LPS-induced nitric oxide (NO), IL-6, and TNF-α production by mouse BV-2 microglia.{50302} In vivo, 6-paradol (6.75 mg/kg per day) lowers blood glucose levels in an oral glucose tolerance test (OGTT) and inhibits weight-gain in a mouse model of high-fat diet-induced obesity.{50303}
Brand:CaymanSKU:27554 - 100 mgAvailable on backorder
6-Paradol is a phenolic ketone that has been found in ginger (Z. officinale) and has diverse biological activities, including antioxidant, anti-inflammatory, and anti-hyperglycemic properties.{50301,50302,50303} It inhibits hydrogen peroxide-induced oxidation of cell-free calf thymus DNA when used at a concentration of 100 μM.{50301} In vitro, 6-paradol (10 μg/ml) inhibits LPS-induced nitric oxide (NO), IL-6, and TNF-α production by mouse BV-2 microglia.{50302} In vivo, 6-paradol (6.75 mg/kg per day) lowers blood glucose levels in an oral glucose tolerance test (OGTT) and inhibits weight-gain in a mouse model of high-fat diet-induced obesity.{50303}
Brand:CaymanSKU:27554 - 25 mgAvailable on backorder
6-Paradol is a phenolic ketone that has been found in ginger (Z. officinale) and has diverse biological activities, including antioxidant, anti-inflammatory, and anti-hyperglycemic properties.{50301,50302,50303} It inhibits hydrogen peroxide-induced oxidation of cell-free calf thymus DNA when used at a concentration of 100 μM.{50301} In vitro, 6-paradol (10 μg/ml) inhibits LPS-induced nitric oxide (NO), IL-6, and TNF-α production by mouse BV-2 microglia.{50302} In vivo, 6-paradol (6.75 mg/kg per day) lowers blood glucose levels in an oral glucose tolerance test (OGTT) and inhibits weight-gain in a mouse model of high-fat diet-induced obesity.{50303}
Brand:CaymanSKU:27554 - 250 mgAvailable on backorder
6-Paradol is a phenolic ketone that has been found in ginger (Z. officinale) and has diverse biological activities, including antioxidant, anti-inflammatory, and anti-hyperglycemic properties.{50301,50302,50303} It inhibits hydrogen peroxide-induced oxidation of cell-free calf thymus DNA when used at a concentration of 100 μM.{50301} In vitro, 6-paradol (10 μg/ml) inhibits LPS-induced nitric oxide (NO), IL-6, and TNF-α production by mouse BV-2 microglia.{50302} In vivo, 6-paradol (6.75 mg/kg per day) lowers blood glucose levels in an oral glucose tolerance test (OGTT) and inhibits weight-gain in a mouse model of high-fat diet-induced obesity.{50303}
Brand:CaymanSKU:27554 - 50 mgAvailable on backorder
6-piperazin-1-yl-Isoquinoline (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:10007148 - 1 gAvailable on backorder
6-piperazin-1-yl-Isoquinoline (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:10007148 - 100 mgAvailable on backorder
6-piperazin-1-yl-Isoquinoline (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:10007148 - 50 mgAvailable on backorder
6-piperazin-1-yl-Isoquinoline (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.
Brand:CaymanSKU:10007148 - 500 mgAvailable on backorder
6-Prenylindole is a bacterial metabolite that has been found in Streptomyces and has antifungal and antimalarial properties.{46404} It is active against A. brassicicola strain TP-F0423 and F. oxysporum f. sp. tulipae TU-4-2 (15 and 30 µg/disc in the paper disc assay), and also drug-resistant P. falciparum strain K1 (IC50 = 21 µg/ml).{46405}
Brand:CaymanSKU:28465 - 1 mgAvailable on backorder
6-Shogaol is a minor, bioactive component of ginger (Zingiber officinale Roscoe) with anti-inflammatory and anticancer properties. It is present in fresh ginger at low levels, but quantities of 6-shogaol are significantly increased in dried ginger. 6-Shogaol induces apoptosis in cancer cells through the production of reactive oxygen species and the activation of caspase, impairs tubulin polymerization, downregulates NF-κB signaling, inhibits the expression of inflammatory mediators, and suppresses Toll-like receptor signaling.{29734} 6-Shogaol-rich extracts have been shown to enhance antioxidant defense mechanisms by inducing Nrf2/ARE-mediated gene expression in cell and animal models.{29733} It can also activate both TRPV1 and TRPA1 channels (EC50s = 0.32 and 16 µM, respectively).{25921}
Brand:CaymanSKU:11901 - 1 mgAvailable on backorder
6-Shogaol is a minor, bioactive component of ginger (Zingiber officinale Roscoe) with anti-inflammatory and anticancer properties. It is present in fresh ginger at low levels, but quantities of 6-shogaol are significantly increased in dried ginger. 6-Shogaol induces apoptosis in cancer cells through the production of reactive oxygen species and the activation of caspase, impairs tubulin polymerization, downregulates NF-κB signaling, inhibits the expression of inflammatory mediators, and suppresses Toll-like receptor signaling.{29734} 6-Shogaol-rich extracts have been shown to enhance antioxidant defense mechanisms by inducing Nrf2/ARE-mediated gene expression in cell and animal models.{29733} It can also activate both TRPV1 and TRPA1 channels (EC50s = 0.32 and 16 µM, respectively).{25921}
Brand:CaymanSKU:11901 - 10 mgAvailable on backorder
6-Shogaol is a minor, bioactive component of ginger (Zingiber officinale Roscoe) with anti-inflammatory and anticancer properties. It is present in fresh ginger at low levels, but quantities of 6-shogaol are significantly increased in dried ginger. 6-Shogaol induces apoptosis in cancer cells through the production of reactive oxygen species and the activation of caspase, impairs tubulin polymerization, downregulates NF-κB signaling, inhibits the expression of inflammatory mediators, and suppresses Toll-like receptor signaling.{29734} 6-Shogaol-rich extracts have been shown to enhance antioxidant defense mechanisms by inducing Nrf2/ARE-mediated gene expression in cell and animal models.{29733} It can also activate both TRPV1 and TRPA1 channels (EC50s = 0.32 and 16 µM, respectively).{25921}
Brand:CaymanSKU:11901 - 5 mgAvailable on backorder
6-thio-2′-Deoxyguanosine (6-thio-dG) is a nucleoside analog that is incorporated into de novo-synthesized telomeres by telomerase.{31123,31124} This induces telomerase dysfunction resulting in telomeric DNA damage and rapid cell death.{31123} This process occurs in cells expressing telomerase but not in telomerase-negative cells.{31123} DNA containing 6-thio-dG inhibits the function of RNase H, preventing the cleavage of DNA-RNA heteroduplexes.{31122} In mouse xenograft studies using A549 lung cancer cells, 6-thio-dG causes a decrease in tumor growth rate associated with telomere dysfunction.{31123}
Brand:CaymanSKU:-Available on backorder
6-thio-2′-Deoxyguanosine (6-thio-dG) is a nucleoside analog that is incorporated into de novo-synthesized telomeres by telomerase.{31123,31124} This induces telomerase dysfunction resulting in telomeric DNA damage and rapid cell death.{31123} This process occurs in cells expressing telomerase but not in telomerase-negative cells.{31123} DNA containing 6-thio-dG inhibits the function of RNase H, preventing the cleavage of DNA-RNA heteroduplexes.{31122} In mouse xenograft studies using A549 lung cancer cells, 6-thio-dG causes a decrease in tumor growth rate associated with telomere dysfunction.{31123}
Brand:CaymanSKU:-Available on backorder
6-thio-2′-Deoxyguanosine (6-thio-dG) is a nucleoside analog that is incorporated into de novo-synthesized telomeres by telomerase.{31123,31124} This induces telomerase dysfunction resulting in telomeric DNA damage and rapid cell death.{31123} This process occurs in cells expressing telomerase but not in telomerase-negative cells.{31123} DNA containing 6-thio-dG inhibits the function of RNase H, preventing the cleavage of DNA-RNA heteroduplexes.{31122} In mouse xenograft studies using A549 lung cancer cells, 6-thio-dG causes a decrease in tumor growth rate associated with telomere dysfunction.{31123}
Brand:CaymanSKU:-Available on backorder
6-thio-2′-Deoxyguanosine (6-thio-dG) is a nucleoside analog that is incorporated into de novo-synthesized telomeres by telomerase.{31123,31124} This induces telomerase dysfunction resulting in telomeric DNA damage and rapid cell death.{31123} This process occurs in cells expressing telomerase but not in telomerase-negative cells.{31123} DNA containing 6-thio-dG inhibits the function of RNase H, preventing the cleavage of DNA-RNA heteroduplexes.{31122} In mouse xenograft studies using A549 lung cancer cells, 6-thio-dG causes a decrease in tumor growth rate associated with telomere dysfunction.{31123}
Brand:CaymanSKU:-Available on backorder
6-Thioguanine (6-TG) is a thio analog of the purine base guanine that incorporates into DNA during replication, inducing double-strand breaks that destabilize its structure and result in cytotoxicity.{25754,25756} Upon incorporation into DNA, 6-TG has been shown to disrupt cytosine methylation by DNA methyltransferases, interfering with the epigenetic pathway of gene regulation.{25757,25758} This compound has been used as a chemotherapeutic for acute leukemia and other types of cancer, including BRCA2-mutated tumors.{25755}
Brand:CaymanSKU:- 6-Thioguanine (6-TG) is a thio analog of the purine base guanine that incorporates into DNA during replication, inducing double-strand breaks that destabilize its structure and result in cytotoxicity.{25754,25756} Upon incorporation into DNA, 6-TG has been shown to disrupt cytosine methylation by DNA methyltransferases, interfering with the epigenetic pathway of gene regulation.{25757,25758} This compound has been used as a chemotherapeutic for acute leukemia and other types of cancer, including BRCA2-mutated tumors.{25755}
Brand:CaymanSKU:- 6-Thioguanine (6-TG) is a thio analog of the purine base guanine that incorporates into DNA during replication, inducing double-strand breaks that destabilize its structure and result in cytotoxicity.{25754,25756} Upon incorporation into DNA, 6-TG has been shown to disrupt cytosine methylation by DNA methyltransferases, interfering with the epigenetic pathway of gene regulation.{25757,25758} This compound has been used as a chemotherapeutic for acute leukemia and other types of cancer, including BRCA2-mutated tumors.{25755}
Brand:CaymanSKU:- 6-Thioguanine (6-TG) is a thio analog of the purine base guanine that incorporates into DNA during replication, inducing double-strand breaks that destabilize its structure and result in cytotoxicity.{25754,25756} Upon incorporation into DNA, 6-TG has been shown to disrupt cytosine methylation by DNA methyltransferases, interfering with the epigenetic pathway of gene regulation.{25757,25758} This compound has been used as a chemotherapeutic for acute leukemia and other types of cancer, including BRCA2-mutated tumors.{25755}
Brand:CaymanSKU:-
6-trans LTB4 is produced by the non-enzymatic hydrolysis of LTA4.{530} Oxidative decomposition of cysteinyl-leukotrienes such as LTC4 in the presence of myeloperoxidase and hypochlorous acid can also produce 6-trans LTB4, but the physiologic importance of this mechanism is not clear.{531} 6-trans LTB4 is relatively inactive compared to LTB4, but chemoattractant properties in neutrophils have been reported.{83}
Brand:CaymanSKU:35250 - 100 µgAvailable on backorder
6-trans LTB4 is produced by the non-enzymatic hydrolysis of LTA4.{530} Oxidative decomposition of cysteinyl-leukotrienes such as LTC4 in the presence of myeloperoxidase and hypochlorous acid can also produce 6-trans LTB4, but the physiologic importance of this mechanism is not clear.{531} 6-trans LTB4 is relatively inactive compared to LTB4, but chemoattractant properties in neutrophils have been reported.{83}
Brand:CaymanSKU:35250 - 25 µgAvailable on backorder
6-trans LTB4 is produced by the non-enzymatic hydrolysis of LTA4.{530} Oxidative decomposition of cysteinyl-leukotrienes such as LTC4 in the presence of myeloperoxidase and hypochlorous acid can also produce 6-trans LTB4, but the physiologic importance of this mechanism is not clear.{531} 6-trans LTB4 is relatively inactive compared to LTB4, but chemoattractant properties in neutrophils have been reported.{83}
Brand:CaymanSKU:35250 - 50 µgAvailable on backorder
6-trans-12-epi Leukotriene B4 (LTB4) is a non-enzymatic hydrolysis product of LTA4. It was originally isolated from glycogen-induced rabbit peritoneal polymorphonuclear leukocytes (PMNL).{530,523} 6-trans-12-epi LTB4 is weakly chemotactic for PMNL, with approximately 20 times less potency than LTB4, and has no effect on the aggregation response.{551}
Brand:CaymanSKU:35265 - 100 µgAvailable on backorder
6-trans-12-epi Leukotriene B4 (LTB4) is a non-enzymatic hydrolysis product of LTA4. It was originally isolated from glycogen-induced rabbit peritoneal polymorphonuclear leukocytes (PMNL).{530,523} 6-trans-12-epi LTB4 is weakly chemotactic for PMNL, with approximately 20 times less potency than LTB4, and has no effect on the aggregation response.{551}
Brand:CaymanSKU:35265 - 25 µgAvailable on backorder
6-trans-12-epi Leukotriene B4 (LTB4) is a non-enzymatic hydrolysis product of LTA4. It was originally isolated from glycogen-induced rabbit peritoneal polymorphonuclear leukocytes (PMNL).{530,523} 6-trans-12-epi LTB4 is weakly chemotactic for PMNL, with approximately 20 times less potency than LTB4, and has no effect on the aggregation response.{551}
Brand:CaymanSKU:35265 - 50 µgAvailable on backorder
6,15-diketo-13,14-dihydro PGF1α is a metabolite of PGI2. It was shown to enhance intracellular cAMP and cholesterol catabolism in bovine arterial smooth muscle cells.{1156}
Brand:CaymanSKU:- 6,15-diketo-13,14-dihydro PGF1α is a metabolite of PGI2. It was shown to enhance intracellular cAMP and cholesterol catabolism in bovine arterial smooth muscle cells.{1156}
Brand:CaymanSKU:- 6,15-diketo-13,14-dihydro PGF1α is a metabolite of PGI2. It was shown to enhance intracellular cAMP and cholesterol catabolism in bovine arterial smooth muscle cells.{1156}
Brand:CaymanSKU:- 6,15-diketo-13,14-dihydro PGF1α is a metabolite of PGI2. It was shown to enhance intracellular cAMP and cholesterol catabolism in bovine arterial smooth muscle cells.{1156}
Brand:CaymanSKU:-
6,7-Dihydro-5H-quinolin-8-one is a synthetic intermediate.{52481,52482} It has been used in the synthesis of tetrahydropyridoazepinones and thiosemicarbazones with anticancer activity.
Brand:CaymanSKU:30480 - 1 gAvailable on backorder
6,7-Dihydro-5H-quinolin-8-one is a synthetic intermediate.{52481,52482} It has been used in the synthesis of tetrahydropyridoazepinones and thiosemicarbazones with anticancer activity.
Brand:CaymanSKU:30480 - 5 gAvailable on backorder
6,7-Dihydro-5H-quinolin-8-one is a synthetic intermediate.{52481,52482} It has been used in the synthesis of tetrahydropyridoazepinones and thiosemicarbazones with anticancer activity.
Brand:CaymanSKU:30480 - 500 mgAvailable on backorder
6,7-dihydroxy Bergamottin (6,7-DHB) is a potent inhibitor of CYP3A4 (IC50 = 25 µM).{14836} It appears to be the primary compound in grapefruit juice that is responsible for inhibition of testosterone 6β-hydrolase activity. Ingestion of grapefruit juice during treatment regimes with drugs normally metabolized by cytochrome P450 enzymes of the CYP3A subfamily results in a substantial increase in plasma concentration of these agents.{14571,14836} However, giving a patient grapefruit juice or just 6,7-DHB could be advantageous in cases where a drug is metabolized too quickly by CYP3A4.
Brand:CaymanSKU:10009598 - 1 mgAvailable on backorder
6,7-dihydroxy Bergamottin (6,7-DHB) is a potent inhibitor of CYP3A4 (IC50 = 25 µM).{14836} It appears to be the primary compound in grapefruit juice that is responsible for inhibition of testosterone 6β-hydrolase activity. Ingestion of grapefruit juice during treatment regimes with drugs normally metabolized by cytochrome P450 enzymes of the CYP3A subfamily results in a substantial increase in plasma concentration of these agents.{14571,14836} However, giving a patient grapefruit juice or just 6,7-DHB could be advantageous in cases where a drug is metabolized too quickly by CYP3A4.
Brand:CaymanSKU:10009598 - 10 mgAvailable on backorder
6,7-dihydroxy Bergamottin (6,7-DHB) is a potent inhibitor of CYP3A4 (IC50 = 25 µM).{14836} It appears to be the primary compound in grapefruit juice that is responsible for inhibition of testosterone 6β-hydrolase activity. Ingestion of grapefruit juice during treatment regimes with drugs normally metabolized by cytochrome P450 enzymes of the CYP3A subfamily results in a substantial increase in plasma concentration of these agents.{14571,14836} However, giving a patient grapefruit juice or just 6,7-DHB could be advantageous in cases where a drug is metabolized too quickly by CYP3A4.
Brand:CaymanSKU:10009598 - 25 mgAvailable on backorder
6,7-dihydroxy Bergamottin (6,7-DHB) is a potent inhibitor of CYP3A4 (IC50 = 25 µM).{14836} It appears to be the primary compound in grapefruit juice that is responsible for inhibition of testosterone 6β-hydrolase activity. Ingestion of grapefruit juice during treatment regimes with drugs normally metabolized by cytochrome P450 enzymes of the CYP3A subfamily results in a substantial increase in plasma concentration of these agents.{14571,14836} However, giving a patient grapefruit juice or just 6,7-DHB could be advantageous in cases where a drug is metabolized too quickly by CYP3A4.
Brand:CaymanSKU:10009598 - 5 mgAvailable on backorder
6,7-dimethyl-5,6,7,8-Tetrahydropterin is a synthetic analog of tetrahydro-L-biopterin (BH4; Item No. 81880), a required cofactor for all NOS isoforms, phenylalanine, tyrosine, and tryptophan hydroxylases, and other enzymes.{1697,32923,32924,32925,32926}
Brand:CaymanSKU:21050 -Out of stock
6,7-dimethyl-5,6,7,8-Tetrahydropterin is a synthetic analog of tetrahydro-L-biopterin (BH4; Item No. 81880), a required cofactor for all NOS isoforms, phenylalanine, tyrosine, and tryptophan hydroxylases, and other enzymes.{1697,32923,32924,32925,32926}
Brand:CaymanSKU:21050 -Out of stock
6,7-dimethyl-5,6,7,8-Tetrahydropterin is a synthetic analog of tetrahydro-L-biopterin (BH4; Item No. 81880), a required cofactor for all NOS isoforms, phenylalanine, tyrosine, and tryptophan hydroxylases, and other enzymes.{1697,32923,32924,32925,32926}
Brand:CaymanSKU:21050 -Out of stock
6,7-dimethyl-5,6,7,8-Tetrahydropterin is a synthetic analog of tetrahydro-L-biopterin (BH4; Item No. 81880), a required cofactor for all NOS isoforms, phenylalanine, tyrosine, and tryptophan hydroxylases, and other enzymes.{1697,32923,32924,32925,32926}
Brand:CaymanSKU:21050 -Out of stock
6,7-dimethyl-8-Ribityllumazine (DMRL) is a natural chromophore of lumazine protein (LumP), a fluorescent accessory protein that induces a blue shift (495 to 475 nm) in luciferase emission wavelengths in bioluminescent Photobacterium.{39355} DMRL binds noncovalently to both the N- and C-terminal domains of LumP. It is also a biosynthetic precursor of riboflavin and substrate of riboflavin synthase.{39356}
Brand:CaymanSKU:23370 - 1 mgAvailable on backorder
6,7-Dimethylpterin is a pteridine that has been found in A549 cells, as well as human urine.{53828,53829}
Brand:CaymanSKU:30887 - 1 gAvailable on backorder
6,7-Dimethylpterin is a pteridine that has been found in A549 cells, as well as human urine.{53828,53829}
Brand:CaymanSKU:30887 - 100 mgAvailable on backorder
6,7-Dimethylpterin is a pteridine that has been found in A549 cells, as well as human urine.{53828,53829}
Brand:CaymanSKU:30887 - 250 mgAvailable on backorder
6,7-Dimethylpterin is a pteridine that has been found in A549 cells, as well as human urine.{53828,53829}
Brand:CaymanSKU:30887 - 500 mgAvailable on backorder
6,7-Dimethyltetrahydropterin is a noncompetitive inhibitor of GTP cyclohydrolase I exhibiting an IC50 of 76-112 µM.{1268}
Brand:CaymanSKU:81040 - 10 mgAvailable on backorder
6,7-Dimethyltetrahydropterin is a noncompetitive inhibitor of GTP cyclohydrolase I exhibiting an IC50 of 76-112 µM.{1268}
Brand:CaymanSKU:81040 - 100 mgAvailable on backorder
6,7-Dimethyltetrahydropterin is a noncompetitive inhibitor of GTP cyclohydrolase I exhibiting an IC50 of 76-112 µM.{1268}
Brand:CaymanSKU:81040 - 50 mgAvailable on backorder
6,7-Dimethyltetrahydropterin is a noncompetitive inhibitor of GTP cyclohydrolase I exhibiting an IC50 of 76-112 µM.{1268}
Brand:CaymanSKU:81040 - 500 mgAvailable on backorder
6,9-Dichloro-1,2,3,4-tetrahydroacridine is a synthetic intermediate in the synthesis of tacrine-based acetylcholinesterase (AChE) inhibitors.{54104} It is also an intermediate in the synthesis of multifunctional tacrine hybrids that possess radical scavenging, amyloid-β aggregation inhibitory, and/or β-secretase 1 (BACE1) inhibitory activities in addition to their activity as AChE inhibitors.{54105,54106}
Brand:CaymanSKU:30502 - 100 mgAvailable on backorder
6,9-Dichloro-1,2,3,4-tetrahydroacridine is a synthetic intermediate in the synthesis of tacrine-based acetylcholinesterase (AChE) inhibitors.{54104} It is also an intermediate in the synthesis of multifunctional tacrine hybrids that possess radical scavenging, amyloid-β aggregation inhibitory, and/or β-secretase 1 (BACE1) inhibitory activities in addition to their activity as AChE inhibitors.{54105,54106}
Brand:CaymanSKU:30502 - 25 mgAvailable on backorder
6,9-Dichloro-1,2,3,4-tetrahydroacridine is a synthetic intermediate in the synthesis of tacrine-based acetylcholinesterase (AChE) inhibitors.{54104} It is also an intermediate in the synthesis of multifunctional tacrine hybrids that possess radical scavenging, amyloid-β aggregation inhibitory, and/or β-secretase 1 (BACE1) inhibitory activities in addition to their activity as AChE inhibitors.{54105,54106}
Brand:CaymanSKU:30502 - 250 mgAvailable on backorder
6,9-Dichloro-1,2,3,4-tetrahydroacridine is a synthetic intermediate in the synthesis of tacrine-based acetylcholinesterase (AChE) inhibitors.{54104} It is also an intermediate in the synthesis of multifunctional tacrine hybrids that possess radical scavenging, amyloid-β aggregation inhibitory, and/or β-secretase 1 (BACE1) inhibitory activities in addition to their activity as AChE inhibitors.{54105,54106}
Brand:CaymanSKU:30502 - 50 mgAvailable on backorder
6′-Sialyllactose consists of the monosaccharide N-acetylneuraminic acid (Item No. 16091) linked to the galactosyl subunit of lactose at the 6 position. This connection is at the 3 position in the related compound, 3’-sialyllactose (Item No. 16617). Both are major milk oligosaccharides that avidly bind several viral strains, including strains of influenza, HIV-1, reovirus, and polyomavirus.{27235,27232,27228,27229,27230,27234} These compounds can be used to differentiate and characterize the binding domains of viruses that recognize N-acetylneuraminic acid-capped cell surface receptors. They are also used as analytical reference standards for quantification in samples such as milk or colostrum.
Brand:CaymanSKU:-Available on backorder
6′-Sialyllactose consists of the monosaccharide N-acetylneuraminic acid (Item No. 16091) linked to the galactosyl subunit of lactose at the 6 position. This connection is at the 3 position in the related compound, 3’-sialyllactose (Item No. 16617). Both are major milk oligosaccharides that avidly bind several viral strains, including strains of influenza, HIV-1, reovirus, and polyomavirus.{27235,27232,27228,27229,27230,27234} These compounds can be used to differentiate and characterize the binding domains of viruses that recognize N-acetylneuraminic acid-capped cell surface receptors. They are also used as analytical reference standards for quantification in samples such as milk or colostrum.
Brand:CaymanSKU:-Available on backorder