Cayman
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5α-Cholestane is a sterol that has been found in dust samples from urban and rural paved and agricultural and public unpaved roads.{47409} It has been used as an internal standard for the quantification of phytosterols by HPLC-MS/MS and fecal sterols by GC-FID and GC-MS.{47410,47411}
Brand:CaymanSKU:26763 - 1 gAvailable on backorder
5α-Cholestane is a sterol that has been found in dust samples from urban and rural paved and agricultural and public unpaved roads.{47409} It has been used as an internal standard for the quantification of phytosterols by HPLC-MS/MS and fecal sterols by GC-FID and GC-MS.{47410,47411}
Brand:CaymanSKU:26763 - 250 mgAvailable on backorder
5α-Cholestane is a sterol that has been found in dust samples from urban and rural paved and agricultural and public unpaved roads.{47409} It has been used as an internal standard for the quantification of phytosterols by HPLC-MS/MS and fecal sterols by GC-FID and GC-MS.{47410,47411}
Brand:CaymanSKU:26763 - 500 mgAvailable on backorder
5α-dihydro Levonorgestrel is a metabolite of the synthetic progestin levonorgestrel (Item No. 10006318).{47343,47344} It lacks in vitro and in vivo estrogenic activity, but induces copulatory behavior in male rats when administered at a dose of 1 mg per animal per day.
Brand:CaymanSKU:27854 - 1 mgAvailable on backorder
5α-dihydro Levonorgestrel is a metabolite of the synthetic progestin levonorgestrel (Item No. 10006318).{47343,47344} It lacks in vitro and in vivo estrogenic activity, but induces copulatory behavior in male rats when administered at a dose of 1 mg per animal per day.
Brand:CaymanSKU:27854 - 5 mgAvailable on backorder
5α-dihydro-11-keto Testosterone is an analytical reference standard that is structurally classified as a steroid hormone. It is a metabolite of 11β-hydroxyandrostenedione and 11β-hydroxytestosterone that has been shown to act as a full androgen receptor agonist with equal potency as that of dihydrotestosterone (Item No. 15874).{31737,31739,31738} The androgenic activity of 5α-dihydro-11-keto testosterone has been implicated in contributing to the androgen pool that drives castration-resistant prostate cancer cells.{31739,31738} This product is intended for forensic and research applications.
Brand:CaymanSKU:20200 -Available on backorder
5α-dihydro-11-keto Testosterone is an analytical reference standard that is structurally classified as a steroid hormone. It is a metabolite of 11β-hydroxyandrostenedione and 11β-hydroxytestosterone that has been shown to act as a full androgen receptor agonist with equal potency as that of dihydrotestosterone (Item No. 15874).{31737,31739,31738} The androgenic activity of 5α-dihydro-11-keto testosterone has been implicated in contributing to the androgen pool that drives castration-resistant prostate cancer cells.{31739,31738} This product is intended for forensic and research applications.
Brand:CaymanSKU:20200 -Available on backorder
5α-Dihydroprogesterone (5α-DHP) is a progesterone receptor agonist and metabolite of progesterone (Item No. 15876).{59179} It is formed from progesterone by 5α-reductase.{59180} It induces gene expression mediated by the progesterone receptor (PR) in reporter assays using HepG2 cells expressing equine PR or human PR (EC50s = 14 and 23.1 nM, respectively).{59179} 5α-DHP (0.7 mg/kg) maintains equine pregnancy in the absence of luteal progesterone. It increases proliferation of C4HD murine mammary cells when used at a concentration of 1 µM and induces tumor formation in a C4HD mouse model of tumorigenesis in a dose-dependent manner.{59181} 5α-DHP levels increase locally following spinal cord injury or traumatic brain injury in rats and ischemic brain injury in mice.{59180}
Brand:CaymanSKU:31505 - 1 gAvailable on backorder
5α-Dihydroprogesterone (5α-DHP) is a progesterone receptor agonist and metabolite of progesterone (Item No. 15876).{59179} It is formed from progesterone by 5α-reductase.{59180} It induces gene expression mediated by the progesterone receptor (PR) in reporter assays using HepG2 cells expressing equine PR or human PR (EC50s = 14 and 23.1 nM, respectively).{59179} 5α-DHP (0.7 mg/kg) maintains equine pregnancy in the absence of luteal progesterone. It increases proliferation of C4HD murine mammary cells when used at a concentration of 1 µM and induces tumor formation in a C4HD mouse model of tumorigenesis in a dose-dependent manner.{59181} 5α-DHP levels increase locally following spinal cord injury or traumatic brain injury in rats and ischemic brain injury in mice.{59180}
Brand:CaymanSKU:31505 - 5 gAvailable on backorder
5α-Dihydroprogesterone (5α-DHP) is a progesterone receptor agonist and metabolite of progesterone (Item No. 15876).{59179} It is formed from progesterone by 5α-reductase.{59180} It induces gene expression mediated by the progesterone receptor (PR) in reporter assays using HepG2 cells expressing equine PR or human PR (EC50s = 14 and 23.1 nM, respectively).{59179} 5α-DHP (0.7 mg/kg) maintains equine pregnancy in the absence of luteal progesterone. It increases proliferation of C4HD murine mammary cells when used at a concentration of 1 µM and induces tumor formation in a C4HD mouse model of tumorigenesis in a dose-dependent manner.{59181} 5α-DHP levels increase locally following spinal cord injury or traumatic brain injury in rats and ischemic brain injury in mice.{59180}
Brand:CaymanSKU:31505 - 500 mgAvailable on backorder
5α-hydroxy Laxogenin is a brassinosteroid analog and a derivative of diosgenin (Item No. 19847).{52168,52167} Topical administration of 5α-hydroxy laxogenin (4, 8, and 12 ppm), in combination with a commercial fertilizer, increases the yield and fresh weight of endives (C. endivia).{52167} It also inhibits sodium chloride-induced decreases in the fresh weight of lettuce shoots and roots when applied topically at concentrations of 0.1 and 1 μM, as well as inhibits increases in ethylene emission at a concentration of 1 μM.{52166}
Brand:CaymanSKU:27665 - 1 gAvailable on backorder
5α-hydroxy Laxogenin is a brassinosteroid analog and a derivative of diosgenin (Item No. 19847).{52168,52167} Topical administration of 5α-hydroxy laxogenin (4, 8, and 12 ppm), in combination with a commercial fertilizer, increases the yield and fresh weight of endives (C. endivia).{52167} It also inhibits sodium chloride-induced decreases in the fresh weight of lettuce shoots and roots when applied topically at concentrations of 0.1 and 1 μM, as well as inhibits increases in ethylene emission at a concentration of 1 μM.{52166}
Brand:CaymanSKU:27665 - 100 mgAvailable on backorder
5α-hydroxy Laxogenin is a brassinosteroid analog and a derivative of diosgenin (Item No. 19847).{52168,52167} Topical administration of 5α-hydroxy laxogenin (4, 8, and 12 ppm), in combination with a commercial fertilizer, increases the yield and fresh weight of endives (C. endivia).{52167} It also inhibits sodium chloride-induced decreases in the fresh weight of lettuce shoots and roots when applied topically at concentrations of 0.1 and 1 μM, as well as inhibits increases in ethylene emission at a concentration of 1 μM.{52166}
Brand:CaymanSKU:27665 - 250 mgAvailable on backorder
5α-hydroxy Laxogenin is a brassinosteroid analog and a derivative of diosgenin (Item No. 19847).{52168,52167} Topical administration of 5α-hydroxy laxogenin (4, 8, and 12 ppm), in combination with a commercial fertilizer, increases the yield and fresh weight of endives (C. endivia).{52167} It also inhibits sodium chloride-induced decreases in the fresh weight of lettuce shoots and roots when applied topically at concentrations of 0.1 and 1 μM, as well as inhibits increases in ethylene emission at a concentration of 1 μM.{52166}
Brand:CaymanSKU:27665 - 500 mgAvailable on backorder
Cholesterol is the most abundant neutral lipid present in the surfactant of the lung epithelial lining fluid. The double bond between carbons 5 and 6 of cholesterol is susceptible to attack by ozone within this surfactant environment. 5α-hydroxy-6-keto Cholesterol (6-oxo-3,5,-diol) is a major metabolite of cholesterol formed during exposure of lung epithelial cells to ozone, with formation of 5β,6β-epoxycholesterol as a predominant precursor.{13448} Exposure of C57BL/6J mice to 0.5-3 ppm ozone produced a dose-dependent formation of 6-oxo-3,5,-diol which was detectable in the bronchalveolar lavage fluid, lavaged cells, and lung homogenates.{13449} 6-Oxo-3,5-diol is a potent inhibitor of cholesterol synthesis in human bronchial epithelial cells with an IC50 of 350 nM and exhibits significant cytotoxicity in the low µM range.{13448} Therefore, the toxic effects of ozone may be mediated by formation oxysterols of this type.
Brand:CaymanSKU:10007601 - 1 mgAvailable on backorder
Cholesterol is the most abundant neutral lipid present in the surfactant of the lung epithelial lining fluid. The double bond between carbons 5 and 6 of cholesterol is susceptible to attack by ozone within this surfactant environment. 5α-hydroxy-6-keto Cholesterol (6-oxo-3,5,-diol) is a major metabolite of cholesterol formed during exposure of lung epithelial cells to ozone, with formation of 5β,6β-epoxycholesterol as a predominant precursor.{13448} Exposure of C57BL/6J mice to 0.5-3 ppm ozone produced a dose-dependent formation of 6-oxo-3,5,-diol which was detectable in the bronchalveolar lavage fluid, lavaged cells, and lung homogenates.{13449} 6-Oxo-3,5-diol is a potent inhibitor of cholesterol synthesis in human bronchial epithelial cells with an IC50 of 350 nM and exhibits significant cytotoxicity in the low µM range.{13448} Therefore, the toxic effects of ozone may be mediated by formation oxysterols of this type.
Brand:CaymanSKU:10007601 - 10 mgAvailable on backorder
Cholesterol is the most abundant neutral lipid present in the surfactant of the lung epithelial lining fluid. The double bond between carbons 5 and 6 of cholesterol is susceptible to attack by ozone within this surfactant environment. 5α-hydroxy-6-keto Cholesterol (6-oxo-3,5,-diol) is a major metabolite of cholesterol formed during exposure of lung epithelial cells to ozone, with formation of 5β,6β-epoxycholesterol as a predominant precursor.{13448} Exposure of C57BL/6J mice to 0.5-3 ppm ozone produced a dose-dependent formation of 6-oxo-3,5,-diol which was detectable in the bronchalveolar lavage fluid, lavaged cells, and lung homogenates.{13449} 6-Oxo-3,5-diol is a potent inhibitor of cholesterol synthesis in human bronchial epithelial cells with an IC50 of 350 nM and exhibits significant cytotoxicity in the low µM range.{13448} Therefore, the toxic effects of ozone may be mediated by formation oxysterols of this type.
Brand:CaymanSKU:10007601 - 5 mgAvailable on backorder
5α,6α-epoxy Cholestanol is an oxysterol and a metabolite of cholesterol produced by oxidation.{45075} 5α,6α-epoxy Cholestanol accumulates in MCF-7 breast cancer cells in a reactive oxygen species-dependent manner following tamoxifen and PBPE application and induces triacylglycerol biosynthesis by binding to liver x receptor β (LXRβ).{45076} 5α,6α-epoxy Cholestanol levels are increased in rat aorta and mesenteric artery following orchidectomy, an effect that can be prevented by a DHA-supplemented diet.{45075} Levels are also increased in post-mortem frontal and occipital cortex of patients with Alzheimer’s disease.{45077}
Brand:CaymanSKU:25539 - 100 mgAvailable on backorder
5α,6α-epoxy Cholestanol is an oxysterol and a metabolite of cholesterol produced by oxidation.{45075} 5α,6α-epoxy Cholestanol accumulates in MCF-7 breast cancer cells in a reactive oxygen species-dependent manner following tamoxifen and PBPE application and induces triacylglycerol biosynthesis by binding to liver x receptor β (LXRβ).{45076} 5α,6α-epoxy Cholestanol levels are increased in rat aorta and mesenteric artery following orchidectomy, an effect that can be prevented by a DHA-supplemented diet.{45075} Levels are also increased in post-mortem frontal and occipital cortex of patients with Alzheimer’s disease.{45077}
Brand:CaymanSKU:25539 - 25 mgAvailable on backorder
5α,6α-epoxy Cholestanol is an oxysterol and a metabolite of cholesterol produced by oxidation.{45075} 5α,6α-epoxy Cholestanol accumulates in MCF-7 breast cancer cells in a reactive oxygen species-dependent manner following tamoxifen and PBPE application and induces triacylglycerol biosynthesis by binding to liver x receptor β (LXRβ).{45076} 5α,6α-epoxy Cholestanol levels are increased in rat aorta and mesenteric artery following orchidectomy, an effect that can be prevented by a DHA-supplemented diet.{45075} Levels are also increased in post-mortem frontal and occipital cortex of patients with Alzheimer’s disease.{45077}
Brand:CaymanSKU:25539 - 250 mgAvailable on backorder
5α,6α-epoxy Cholestanol is an oxysterol and a metabolite of cholesterol produced by oxidation.{45075} 5α,6α-epoxy Cholestanol accumulates in MCF-7 breast cancer cells in a reactive oxygen species-dependent manner following tamoxifen and PBPE application and induces triacylglycerol biosynthesis by binding to liver x receptor β (LXRβ).{45076} 5α,6α-epoxy Cholestanol levels are increased in rat aorta and mesenteric artery following orchidectomy, an effect that can be prevented by a DHA-supplemented diet.{45075} Levels are also increased in post-mortem frontal and occipital cortex of patients with Alzheimer’s disease.{45077}
Brand:CaymanSKU:25539 - 50 mgAvailable on backorder
5α,6β-Dihydroxycholestanol is an oxysterol metabolite of cholesterol formed from conversion of cholesterol epoxides by 5,6-epoxysterol hydrolase.{41987,41988} It inhibits NMDA-mediated calcium influx in HEK293 cells expressing NR1/NR2B NMDA receptors in a concentration-dependent manner. It also binds to voltage-gated sodium (Nav) channels and decreases action potentials in hippocampal neurons in vitro when used at a concentration of 10 µM.{41988} It increases survival of spinal cord motoneurons, cortical neurons, and cerebellar granule neurons in vitro when used at concentrations ranging from 5 to 15 µM.{41989} 5α,6β-Dihydroxycholestanol is neuroprotective in a rat model of cerebral ischemia when administered at a dose of 12 mg/kg and increases latency to seizure onset and reduces severity of seizures induced by pentylenetetrazole (PTZ; Item No. 18682) in rats. 5α,6β-Dihydroxycholestanol has been used as a replacement for cholesterol in the study of cholesterol binding proteins.{41990}
Brand:CaymanSKU:25538 - 10 mgAvailable on backorder
5α,6β-Dihydroxycholestanol is an oxysterol metabolite of cholesterol formed from conversion of cholesterol epoxides by 5,6-epoxysterol hydrolase.{41987,41988} It inhibits NMDA-mediated calcium influx in HEK293 cells expressing NR1/NR2B NMDA receptors in a concentration-dependent manner. It also binds to voltage-gated sodium (Nav) channels and decreases action potentials in hippocampal neurons in vitro when used at a concentration of 10 µM.{41988} It increases survival of spinal cord motoneurons, cortical neurons, and cerebellar granule neurons in vitro when used at concentrations ranging from 5 to 15 µM.{41989} 5α,6β-Dihydroxycholestanol is neuroprotective in a rat model of cerebral ischemia when administered at a dose of 12 mg/kg and increases latency to seizure onset and reduces severity of seizures induced by pentylenetetrazole (PTZ; Item No. 18682) in rats. 5α,6β-Dihydroxycholestanol has been used as a replacement for cholesterol in the study of cholesterol binding proteins.{41990}
Brand:CaymanSKU:25538 - 25 mgAvailable on backorder
5α,6β-Dihydroxycholestanol is an oxysterol metabolite of cholesterol formed from conversion of cholesterol epoxides by 5,6-epoxysterol hydrolase.{41987,41988} It inhibits NMDA-mediated calcium influx in HEK293 cells expressing NR1/NR2B NMDA receptors in a concentration-dependent manner. It also binds to voltage-gated sodium (Nav) channels and decreases action potentials in hippocampal neurons in vitro when used at a concentration of 10 µM.{41988} It increases survival of spinal cord motoneurons, cortical neurons, and cerebellar granule neurons in vitro when used at concentrations ranging from 5 to 15 µM.{41989} 5α,6β-Dihydroxycholestanol is neuroprotective in a rat model of cerebral ischemia when administered at a dose of 12 mg/kg and increases latency to seizure onset and reduces severity of seizures induced by pentylenetetrazole (PTZ; Item No. 18682) in rats. 5α,6β-Dihydroxycholestanol has been used as a replacement for cholesterol in the study of cholesterol binding proteins.{41990}
Brand:CaymanSKU:25538 - 5 mgAvailable on backorder
5α,6β-Dihydroxycholestanol is an oxysterol metabolite of cholesterol formed from conversion of cholesterol epoxides by 5,6-epoxysterol hydrolase.{41987,41988} It inhibits NMDA-mediated calcium influx in HEK293 cells expressing NR1/NR2B NMDA receptors in a concentration-dependent manner. It also binds to voltage-gated sodium (Nav) channels and decreases action potentials in hippocampal neurons in vitro when used at a concentration of 10 µM.{41988} It increases survival of spinal cord motoneurons, cortical neurons, and cerebellar granule neurons in vitro when used at concentrations ranging from 5 to 15 µM.{41989} 5α,6β-Dihydroxycholestanol is neuroprotective in a rat model of cerebral ischemia when administered at a dose of 12 mg/kg and increases latency to seizure onset and reduces severity of seizures induced by pentylenetetrazole (PTZ; Item No. 18682) in rats. 5α,6β-Dihydroxycholestanol has been used as a replacement for cholesterol in the study of cholesterol binding proteins.{41990}
Brand:CaymanSKU:25538 - 50 mgAvailable on backorder
5α,6β-Dihydroxycholestanol-d7 is intended for use as an internal standard for the quantification of 5α,6β-dihydroxycholestanol (Item No. 25538) by GC- or LC-MS. 5α,6β-Dihydroxycholestanol is an oxysterol metabolite of cholesterol formed from conversion of cholesterol epoxides by 5,6-epoxysterol hydrolase.{41987,41988} It inhibits NMDA-mediated calcium influx in HEK293 cells expressing NR1/NR2B NMDA receptors in a concentration-dependent manner. It also binds to voltage-gated sodium (Nav) channels and decreases action potentials in hippocampal neurons in vitro when used at a concentration of 10 µM.{41988} It increases survival of spinal cord motoneurons, cortical neurons, and cerebellar granule neurons in vitro when used at concentrations ranging from 5 to 15 µM.{41989} 5α,6β-Dihydroxycholestanol is neuroprotective in a rat model of cerebral ischemia when administered at a dose of 12 mg/kg and increases latency to seizure onset and reduces severity of seizures induced by pentylenetetrazole (PTZ; Item No. 18682) in rats. 5α,6β-Dihydroxycholestanol has been used as a replacement for cholesterol in the study of cholesterol binding proteins.{41990}
Brand:CaymanSKU:25968 - 1 mgAvailable on backorder
5α,6β-Dihydroxycholestanol-d7 is intended for use as an internal standard for the quantification of 5α,6β-dihydroxycholestanol (Item No. 25538) by GC- or LC-MS. 5α,6β-Dihydroxycholestanol is an oxysterol metabolite of cholesterol formed from conversion of cholesterol epoxides by 5,6-epoxysterol hydrolase.{41987,41988} It inhibits NMDA-mediated calcium influx in HEK293 cells expressing NR1/NR2B NMDA receptors in a concentration-dependent manner. It also binds to voltage-gated sodium (Nav) channels and decreases action potentials in hippocampal neurons in vitro when used at a concentration of 10 µM.{41988} It increases survival of spinal cord motoneurons, cortical neurons, and cerebellar granule neurons in vitro when used at concentrations ranging from 5 to 15 µM.{41989} 5α,6β-Dihydroxycholestanol is neuroprotective in a rat model of cerebral ischemia when administered at a dose of 12 mg/kg and increases latency to seizure onset and reduces severity of seizures induced by pentylenetetrazole (PTZ; Item No. 18682) in rats. 5α,6β-Dihydroxycholestanol has been used as a replacement for cholesterol in the study of cholesterol binding proteins.{41990}
Brand:CaymanSKU:25968 - 500 µgAvailable on backorder
5β,6β-epoxy Cholestanol is an oxidative metabolite of cholesterol that is formed via radical and non-radical oxidation of cholesterol at the 5,6-double bond.{13448,41987} It induces release of lactate dehydrogenase (LDH) and apoptosis in macrophage-differentiated U937 cells.{39949} 5β,6β-epoxy Cholestanol has been found in human fatty streaks and advanced atherosclerotic lesions but is not present in normal aortic tissue.{39950}
Brand:CaymanSKU:25603 - 10 mgAvailable on backorder
5β,6β-epoxy Cholestanol is an oxidative metabolite of cholesterol that is formed via radical and non-radical oxidation of cholesterol at the 5,6-double bond.{13448,41987} It induces release of lactate dehydrogenase (LDH) and apoptosis in macrophage-differentiated U937 cells.{39949} 5β,6β-epoxy Cholestanol has been found in human fatty streaks and advanced atherosclerotic lesions but is not present in normal aortic tissue.{39950}
Brand:CaymanSKU:25603 - 100 mgAvailable on backorder
5β,6β-epoxy Cholestanol is an oxidative metabolite of cholesterol that is formed via radical and non-radical oxidation of cholesterol at the 5,6-double bond.{13448,41987} It induces release of lactate dehydrogenase (LDH) and apoptosis in macrophage-differentiated U937 cells.{39949} 5β,6β-epoxy Cholestanol has been found in human fatty streaks and advanced atherosclerotic lesions but is not present in normal aortic tissue.{39950}
Brand:CaymanSKU:25603 - 50 mgAvailable on backorder
Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influence on target neurons. These receptors are the major targets for benzodiazepines and related anxiolytic drugs.{18157} 6-(4-Methoxyphenyl)-3-pyridazinamine is an aminopyridazine derivative that acts as a GABAA receptor antagonist.{28832} It can also be used as an intermediate in the synthesis of SR 95531 (Item No. 14585).{28832}
Brand:CaymanSKU:-Available on backorder
Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influence on target neurons. These receptors are the major targets for benzodiazepines and related anxiolytic drugs.{18157} 6-(4-Methoxyphenyl)-3-pyridazinamine is an aminopyridazine derivative that acts as a GABAA receptor antagonist.{28832} It can also be used as an intermediate in the synthesis of SR 95531 (Item No. 14585).{28832}
Brand:CaymanSKU:-Available on backorder
Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influence on target neurons. These receptors are the major targets for benzodiazepines and related anxiolytic drugs.{18157} 6-(4-Methoxyphenyl)-3-pyridazinamine is an aminopyridazine derivative that acts as a GABAA receptor antagonist.{28832} It can also be used as an intermediate in the synthesis of SR 95531 (Item No. 14585).{28832}
Brand:CaymanSKU:-Available on backorder
Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influence on target neurons. These receptors are the major targets for benzodiazepines and related anxiolytic drugs.{18157} 6-(4-Methoxyphenyl)-3-pyridazinamine is an aminopyridazine derivative that acts as a GABAA receptor antagonist.{28832} It can also be used as an intermediate in the synthesis of SR 95531 (Item No. 14585).{28832}
Brand:CaymanSKU:-Available on backorder
6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine (Item No. 26420).{48080} It inhibits protein folding activity of the ribosome (PFAR) when used at a concentration of 150 µM.{48081} 6A-8tFP directly competes with protein substrates for the ribosomal active site.
Brand:CaymanSKU:26419 - 1 mgAvailable on backorder
6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine (Item No. 26420).{48080} It inhibits protein folding activity of the ribosome (PFAR) when used at a concentration of 150 µM.{48081} 6A-8tFP directly competes with protein substrates for the ribosomal active site.
Brand:CaymanSKU:26419 - 10 mgAvailable on backorder
6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine (Item No. 26420).{48080} It inhibits protein folding activity of the ribosome (PFAR) when used at a concentration of 150 µM.{48081} 6A-8tFP directly competes with protein substrates for the ribosomal active site.
Brand:CaymanSKU:26419 - 25 mgAvailable on backorder
6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine (Item No. 26420).{48080} It inhibits protein folding activity of the ribosome (PFAR) when used at a concentration of 150 µM.{48081} 6A-8tFP directly competes with protein substrates for the ribosomal active site.
Brand:CaymanSKU:26419 - 5 mgAvailable on backorder
6-Aminocaproic acid is an inhibitor of the plasmin activating enzymes streptokinase, fibrinokinase, and urokinase (IC50s = ~8 μM for all in an enzyme assay).{37233} It is selective for plasmin activating enzymes over trypsin (IC50 = >500 μM). 6-Aminocaproic acid inhibits in vitro plasmin activation and fibrinolysis in a dose-dependent manner. Ex vivo, 6-aminocaproic acid reduces fibrinolysis in dog plasma following i.p. administration at doses ranging from 20-100 mg/kg.{37234} Formulations containing 6-aminocaproic acid have been used to decrease postoperative blood transfusion rates following knee surgery.{37235}
Brand:CaymanSKU:23724 - 100 gAvailable on backorder
6-Aminocaproic acid is an inhibitor of the plasmin activating enzymes streptokinase, fibrinokinase, and urokinase (IC50s = ~8 μM for all in an enzyme assay).{37233} It is selective for plasmin activating enzymes over trypsin (IC50 = >500 μM). 6-Aminocaproic acid inhibits in vitro plasmin activation and fibrinolysis in a dose-dependent manner. Ex vivo, 6-aminocaproic acid reduces fibrinolysis in dog plasma following i.p. administration at doses ranging from 20-100 mg/kg.{37234} Formulations containing 6-aminocaproic acid have been used to decrease postoperative blood transfusion rates following knee surgery.{37235}
Brand:CaymanSKU:23724 - 50 gAvailable on backorder
6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase (Ki = 0.46 μM).{16482} Through this action, 6-AN interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, like cisplatin, in killing cancer cells (IC50 = 0.5 mM).{16480,16483} 6-AN also reduces cardiovascular oxidative injury following ischemia/reperfusion.{16479} In addition, 6-AN causes glial neurodegeneration.{16481}
Brand:CaymanSKU:10009315 - 1 gAvailable on backorder
6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase (Ki = 0.46 μM).{16482} Through this action, 6-AN interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, like cisplatin, in killing cancer cells (IC50 = 0.5 mM).{16480,16483} 6-AN also reduces cardiovascular oxidative injury following ischemia/reperfusion.{16479} In addition, 6-AN causes glial neurodegeneration.{16481}
Brand:CaymanSKU:10009315 - 100 mgAvailable on backorder
6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase (Ki = 0.46 μM).{16482} Through this action, 6-AN interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, like cisplatin, in killing cancer cells (IC50 = 0.5 mM).{16480,16483} 6-AN also reduces cardiovascular oxidative injury following ischemia/reperfusion.{16479} In addition, 6-AN causes glial neurodegeneration.{16481}
Brand:CaymanSKU:10009315 - 250 mgAvailable on backorder
6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase (Ki = 0.46 μM).{16482} Through this action, 6-AN interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, like cisplatin, in killing cancer cells (IC50 = 0.5 mM).{16480,16483} 6-AN also reduces cardiovascular oxidative injury following ischemia/reperfusion.{16479} In addition, 6-AN causes glial neurodegeneration.{16481}
Brand:CaymanSKU:10009315 - 500 mgAvailable on backorder
6-Aminophenanthridine is an antiprion agent.{47109} It inhibits prion formation in yeast- and mammalian-based screening assays when used alone and, to a greater extent, when used in combination with the α2-adrenergic receptor agonist guanabenz (Item No. 10851). 6-Aminophenanthridine (300 µM) inhibits protein folding activity of the ribosome (PFAR) by directly competing with protein substrates for the active site and decreases the yield of refolded protein without affecting the refolding rate.{47109,47110,48081} It prevents progressive wing position defects in a Drosophila model of oculopharyngeal muscular dystrophy (OPMD) when larvae are raised on medium containing doses ranging from 300 to 400 µM and in adults following dietary administration of 1-3 mM doses.{47111} 6-Aminophenanthridine also reduces muscle degeneration and decreases the number of nuclear inclusions in thoracic muscle in a Drosophila model of OPMD.
Brand:CaymanSKU:26420 - 1 mgAvailable on backorder
6-Aminophenanthridine is an antiprion agent.{47109} It inhibits prion formation in yeast- and mammalian-based screening assays when used alone and, to a greater extent, when used in combination with the α2-adrenergic receptor agonist guanabenz (Item No. 10851). 6-Aminophenanthridine (300 µM) inhibits protein folding activity of the ribosome (PFAR) by directly competing with protein substrates for the active site and decreases the yield of refolded protein without affecting the refolding rate.{47109,47110,48081} It prevents progressive wing position defects in a Drosophila model of oculopharyngeal muscular dystrophy (OPMD) when larvae are raised on medium containing doses ranging from 300 to 400 µM and in adults following dietary administration of 1-3 mM doses.{47111} 6-Aminophenanthridine also reduces muscle degeneration and decreases the number of nuclear inclusions in thoracic muscle in a Drosophila model of OPMD.
Brand:CaymanSKU:26420 - 10 mgAvailable on backorder
6-Aminophenanthridine is an antiprion agent.{47109} It inhibits prion formation in yeast- and mammalian-based screening assays when used alone and, to a greater extent, when used in combination with the α2-adrenergic receptor agonist guanabenz (Item No. 10851). 6-Aminophenanthridine (300 µM) inhibits protein folding activity of the ribosome (PFAR) by directly competing with protein substrates for the active site and decreases the yield of refolded protein without affecting the refolding rate.{47109,47110,48081} It prevents progressive wing position defects in a Drosophila model of oculopharyngeal muscular dystrophy (OPMD) when larvae are raised on medium containing doses ranging from 300 to 400 µM and in adults following dietary administration of 1-3 mM doses.{47111} 6-Aminophenanthridine also reduces muscle degeneration and decreases the number of nuclear inclusions in thoracic muscle in a Drosophila model of OPMD.
Brand:CaymanSKU:26420 - 25 mgAvailable on backorder
6-Aminophenanthridine is an antiprion agent.{47109} It inhibits prion formation in yeast- and mammalian-based screening assays when used alone and, to a greater extent, when used in combination with the α2-adrenergic receptor agonist guanabenz (Item No. 10851). 6-Aminophenanthridine (300 µM) inhibits protein folding activity of the ribosome (PFAR) by directly competing with protein substrates for the active site and decreases the yield of refolded protein without affecting the refolding rate.{47109,47110,48081} It prevents progressive wing position defects in a Drosophila model of oculopharyngeal muscular dystrophy (OPMD) when larvae are raised on medium containing doses ranging from 300 to 400 µM and in adults following dietary administration of 1-3 mM doses.{47111} 6-Aminophenanthridine also reduces muscle degeneration and decreases the number of nuclear inclusions in thoracic muscle in a Drosophila model of OPMD.
Brand:CaymanSKU:26420 - 5 mgAvailable on backorder
6-APB is a phenethylamine designer drug which is analogous to the amphetamine MDA in that the 3,4-methylendioxyphenyl ring system has been replaced with a benzofuran ring. The physiological and toxicological actions of this compound have not been assessed. This product is intended for forensic and research applications.
Brand:CaymanSKU:11079 - 1 mgAvailable on backorder
6-APB is a phenethylamine designer drug which is analogous to the amphetamine MDA in that the 3,4-methylendioxyphenyl ring system has been replaced with a benzofuran ring. The physiological and toxicological actions of this compound have not been assessed. This product is intended for forensic and research applications.
Brand:CaymanSKU:11079 - 10 mgAvailable on backorder
6-APB is a phenethylamine designer drug which is analogous to the amphetamine MDA in that the 3,4-methylendioxyphenyl ring system has been replaced with a benzofuran ring. The physiological and toxicological actions of this compound have not been assessed. This product is intended for forensic and research applications.
Brand:CaymanSKU:11079 - 5 mgAvailable on backorder
6-APDB, known more formally as 2,3-dihydro-α-methyl-6-benzofuranethanamine, is an analog of the psychedelic drugs MDA and 6-APB. This compound fully substitutes for the entactogen MBDB in animal drug-discrimination studies and blocks the reuptake of serotonin (IC50 = 322 nM) more potently than dopamine and norepinephrine (IC50s = 1,997 and 980 nM, respectively) by rat synaptosomes.{21930} This product is intended for forensic and research applications.
Brand:CaymanSKU:11146 - 1 mgAvailable on backorder
6-APDB, known more formally as 2,3-dihydro-α-methyl-6-benzofuranethanamine, is an analog of the psychedelic drugs MDA and 6-APB. This compound fully substitutes for the entactogen MBDB in animal drug-discrimination studies and blocks the reuptake of serotonin (IC50 = 322 nM) more potently than dopamine and norepinephrine (IC50s = 1,997 and 980 nM, respectively) by rat synaptosomes.{21930} This product is intended for forensic and research applications.
Brand:CaymanSKU:11146 - 10 mgAvailable on backorder
6-APDB, known more formally as 2,3-dihydro-α-methyl-6-benzofuranethanamine, is an analog of the psychedelic drugs MDA and 6-APB. This compound fully substitutes for the entactogen MBDB in animal drug-discrimination studies and blocks the reuptake of serotonin (IC50 = 322 nM) more potently than dopamine and norepinephrine (IC50s = 1,997 and 980 nM, respectively) by rat synaptosomes.{21930} This product is intended for forensic and research applications.
Brand:CaymanSKU:11146 - 5 mgAvailable on backorder
6-Azidohexanoic acid is a six carbon saturated fatty acid with an ω-terminal azide group. This terminal group allows conjugation with compounds containing alkyne groups through a copper(I)-catalyzed cycloaddition reaction, also known as click chemistry. 6-Azidohexanoic acid is commonly used as a linker that is first acylated to one compound to create a derivative that can then be joined to another compound using click chemistry.{26954,26955,26956}
Brand:CaymanSKU:-Out of stock
6-Azidohexanoic acid is a six carbon saturated fatty acid with an ω-terminal azide group. This terminal group allows conjugation with compounds containing alkyne groups through a copper(I)-catalyzed cycloaddition reaction, also known as click chemistry. 6-Azidohexanoic acid is commonly used as a linker that is first acylated to one compound to create a derivative that can then be joined to another compound using click chemistry.{26954,26955,26956}
Brand:CaymanSKU:-Out of stock
6-Azidohexanoic acid is a six carbon saturated fatty acid with an ω-terminal azide group. This terminal group allows conjugation with compounds containing alkyne groups through a copper(I)-catalyzed cycloaddition reaction, also known as click chemistry. 6-Azidohexanoic acid is commonly used as a linker that is first acylated to one compound to create a derivative that can then be joined to another compound using click chemistry.{26954,26955,26956}
Brand:CaymanSKU:-Out of stock
6-Bromo-2-oxindole is a secondary metabolite that has been isolated from the sea squirt (D. skoogi).{37584} It is cytotoxic to MDA-MB-231 breast cancer cells with an IC50 value of 74.41 µM. 6-Bromo-2-oxindole has been used in the synthesis of 1,3-disubstituted 2-oxindoles and indolin-2-one p38α inhibitors, which have anti-inflammatory activity.{37585,37586}
Brand:CaymanSKU:20041 -Available on backorder
6-Bromo-2-oxindole is a secondary metabolite that has been isolated from the sea squirt (D. skoogi).{37584} It is cytotoxic to MDA-MB-231 breast cancer cells with an IC50 value of 74.41 µM. 6-Bromo-2-oxindole has been used in the synthesis of 1,3-disubstituted 2-oxindoles and indolin-2-one p38α inhibitors, which have anti-inflammatory activity.{37585,37586}
Brand:CaymanSKU:20041 -Available on backorder
6-Bromo-2-oxindole is a secondary metabolite that has been isolated from the sea squirt (D. skoogi).{37584} It is cytotoxic to MDA-MB-231 breast cancer cells with an IC50 value of 74.41 µM. 6-Bromo-2-oxindole has been used in the synthesis of 1,3-disubstituted 2-oxindoles and indolin-2-one p38α inhibitors, which have anti-inflammatory activity.{37585,37586}
Brand:CaymanSKU:20041 -Available on backorder
Brand:CaymanSKU:10007080 - 1 gAvailable on backorder
Brand:CaymanSKU:10007080 - 5 gAvailable on backorder
Brand:CaymanSKU:10007080 - 500 mgAvailable on backorder
6-Carboxyfluorescein (6-FAM) is a single isomer derivative of 5(6)-carboxyfluorescein (Item No. 17172) that can be used to fluorescently label biomolecules through the interaction of carboxylic acid with primary amines.{13893} It demonstrates excitation/emission maxima of 492 and 518 nm, respectively.
Brand:CaymanSKU:21233 -Out of stock
6-Carboxyfluorescein (6-FAM) is a single isomer derivative of 5(6)-carboxyfluorescein (Item No. 17172) that can be used to fluorescently label biomolecules through the interaction of carboxylic acid with primary amines.{13893} It demonstrates excitation/emission maxima of 492 and 518 nm, respectively.
Brand:CaymanSKU:21233 -Out of stock
6-Carboxyfluorescein (6-FAM) is a single isomer derivative of 5(6)-carboxyfluorescein (Item No. 17172) that can be used to fluorescently label biomolecules through the interaction of carboxylic acid with primary amines.{13893} It demonstrates excitation/emission maxima of 492 and 518 nm, respectively.
Brand:CaymanSKU:21233 -Out of stock
6-Carboxyfluorescein (6-FAM) is a single isomer derivative of 5(6)-carboxyfluorescein (Item No. 17172) that can be used to fluorescently label biomolecules through the interaction of carboxylic acid with primary amines.{13893} It demonstrates excitation/emission maxima of 492 and 518 nm, respectively.
Brand:CaymanSKU:21233 -Out of stock
6-Carboxytetramethylrhodamine is a fluorescent dye that has commonly been used for the covalent labeling of oligonucleotides for DNA analysis.{53071,53072} It displays excitation/emission maxima of 543/572 nm, respectively. 6-Carboxytetramethylrhodamine has been used in various DNA-protein binding studies, DNA FRET experiments, and as a standard reporter or quencher dye in RT-PCR.
Brand:CaymanSKU:29046 - 1 mgAvailable on backorder
6-Carboxytetramethylrhodamine is a fluorescent dye that has commonly been used for the covalent labeling of oligonucleotides for DNA analysis.{53071,53072} It displays excitation/emission maxima of 543/572 nm, respectively. 6-Carboxytetramethylrhodamine has been used in various DNA-protein binding studies, DNA FRET experiments, and as a standard reporter or quencher dye in RT-PCR.
Brand:CaymanSKU:29046 - 10 mgAvailable on backorder
6-Carboxytetramethylrhodamine is a fluorescent dye that has commonly been used for the covalent labeling of oligonucleotides for DNA analysis.{53071,53072} It displays excitation/emission maxima of 543/572 nm, respectively. 6-Carboxytetramethylrhodamine has been used in various DNA-protein binding studies, DNA FRET experiments, and as a standard reporter or quencher dye in RT-PCR.
Brand:CaymanSKU:29046 - 5 mgAvailable on backorder
6-Carboxytetramethylrhodamine is a fluorescent dye that has commonly been used for the covalent labeling of oligonucleotides for DNA analysis.{53071,53072} It displays excitation/emission maxima of 543/572 nm, respectively. 6-Carboxytetramethylrhodamine has been used in various DNA-protein binding studies, DNA FRET experiments, and as a standard reporter or quencher dye in RT-PCR.
Brand:CaymanSKU:29046 - 50 mgAvailable on backorder
6-Chloro-2-fluoropurine is a heterocyclic building block.{48982,48983} It has been used in the synthesis of purine nucleosides that inhibit cyclin-dependent kinases (CDKs) in vitro.{48982} 6-Chloro-2-fluoropurine has also been used in the synthesis of purine nucleosides that are active against HIV-1 and hepatitis B virus (HBV) in vitro.{48983}
Brand:CaymanSKU:30481 - 1 gAvailable on backorder
6-Chloro-2-fluoropurine is a heterocyclic building block.{48982,48983} It has been used in the synthesis of purine nucleosides that inhibit cyclin-dependent kinases (CDKs) in vitro.{48982} 6-Chloro-2-fluoropurine has also been used in the synthesis of purine nucleosides that are active against HIV-1 and hepatitis B virus (HBV) in vitro.{48983}
Brand:CaymanSKU:30481 - 250 mgAvailable on backorder
6-Chloro-3-indolyl-β-D-glucuronide is a chromogenic substrate for β-glucuronidase.{55026} Upon cleavage by β-glucuronidase, an insoluble salmon precipitate is formed that can be used in histochemical analysis of β-glucuronidase activity.
Brand:CaymanSKU:30131 - 1 gAvailable on backorder
6-Chloro-3-indolyl-β-D-glucuronide is a chromogenic substrate for β-glucuronidase.{55026} Upon cleavage by β-glucuronidase, an insoluble salmon precipitate is formed that can be used in histochemical analysis of β-glucuronidase activity.
Brand:CaymanSKU:30131 - 100 mgAvailable on backorder
6-Chloro-3-indolyl-β-D-glucuronide is a chromogenic substrate for β-glucuronidase.{55026} Upon cleavage by β-glucuronidase, an insoluble salmon precipitate is formed that can be used in histochemical analysis of β-glucuronidase activity.
Brand:CaymanSKU:30131 - 250 mgAvailable on backorder
6-Chloro-3-indolyl-β-D-glucuronide is a chromogenic substrate for β-glucuronidase.{55026} Upon cleavage by β-glucuronidase, an insoluble salmon precipitate is formed that can be used in histochemical analysis of β-glucuronidase activity.
Brand:CaymanSKU:30131 - 500 mgAvailable on backorder
6-Diazo-5-oxo-L-nor-Leucine (DON) is a glutamine analog that inhibits glutaminases (Ki = 6 µM) and other glutamine-utilizing enzymes, including cytidine triphosphate synthase (CTPS), which uses glutamine in the synthesis of CTP.{28578,28576,28577} DON is commonly used in cells or tissues but its use in whole animals is limited by its teratogenicity.{28577,28574,28575}
Brand:CaymanSKU:-Available on backorder
6-Diazo-5-oxo-L-nor-Leucine (DON) is a glutamine analog that inhibits glutaminases (Ki = 6 µM) and other glutamine-utilizing enzymes, including cytidine triphosphate synthase (CTPS), which uses glutamine in the synthesis of CTP.{28578,28576,28577} DON is commonly used in cells or tissues but its use in whole animals is limited by its teratogenicity.{28577,28574,28575}
Brand:CaymanSKU:-Available on backorder
6-Diazo-5-oxo-L-nor-Leucine (DON) is a glutamine analog that inhibits glutaminases (Ki = 6 µM) and other glutamine-utilizing enzymes, including cytidine triphosphate synthase (CTPS), which uses glutamine in the synthesis of CTP.{28578,28576,28577} DON is commonly used in cells or tissues but its use in whole animals is limited by its teratogenicity.{28577,28574,28575}
Brand:CaymanSKU:-Available on backorder
6-Diazo-5-oxo-L-nor-Leucine (DON) is a glutamine analog that inhibits glutaminases (Ki = 6 µM) and other glutamine-utilizing enzymes, including cytidine triphosphate synthase (CTPS), which uses glutamine in the synthesis of CTP.{28578,28576,28577} DON is commonly used in cells or tissues but its use in whole animals is limited by its teratogenicity.{28577,28574,28575}
Brand:CaymanSKU:-Available on backorder