Cayman
Showing 6301–6450 of 45550 results
-
4′-Aminomethyl-4,5′,8-trimethylpsoralen is a bifunctional photoreactive agent for crosslinking nucleic acids.{28101,28103} In the dark, it intercalates into double-stranded regions in DNA or RNA. Upon long wavelength UV irradiation (e.g., 365 nm), 4′-aminomethyl-4,5′,8-trimethylpsoralen first forms a covalent monoadduct with a pyrimidine base, followed by covalently linking with an adjacent pyrimidine on the opposite strand.{28101,28103} Short wavelength UV irradiation (e.g., 254 nm) reverses this reaction. 4′-Aminomethyl-4,5′,8-trimethylpsoralen has a high binding affinity for RNA and has been used to study different types of RNA from diverse organisms, including viruses.{28099,28100,28102}
Brand:CaymanSKU:-Out of stock
4’-bromo-Resveratrol is a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3).{33950} It is a brominated derivative of resveratrol, a polyphenol found in red wine, which activates SIRT1 and inhibits SIRT3. The use of 4’-bromo-resveratrol in an SIRT3 crystal binding study revealed two compound binding sites which, combined with homology modeling, suggested that the second site may account for the paradoxical activation of SIRT1 by unmodified resveratrol.{33950}
Brand:CaymanSKU:20541 -Available on backorder
4’-bromo-Resveratrol is a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3).{33950} It is a brominated derivative of resveratrol, a polyphenol found in red wine, which activates SIRT1 and inhibits SIRT3. The use of 4’-bromo-resveratrol in an SIRT3 crystal binding study revealed two compound binding sites which, combined with homology modeling, suggested that the second site may account for the paradoxical activation of SIRT1 by unmodified resveratrol.{33950}
Brand:CaymanSKU:20541 -Available on backorder
4’-bromo-Resveratrol is a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3).{33950} It is a brominated derivative of resveratrol, a polyphenol found in red wine, which activates SIRT1 and inhibits SIRT3. The use of 4’-bromo-resveratrol in an SIRT3 crystal binding study revealed two compound binding sites which, combined with homology modeling, suggested that the second site may account for the paradoxical activation of SIRT1 by unmodified resveratrol.{33950}
Brand:CaymanSKU:20541 -Available on backorder
4′-chloro-α-Pyrrolidinopropiophenone is a halogen-substituted form of the stimulant α-Pyrrolidinopropiophenone (Item No. 10445). The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:9002179 - 10 mgAvailable on backorder
4′-chloro-α-Pyrrolidinopropiophenone is a halogen-substituted form of the stimulant α-Pyrrolidinopropiophenone (Item No. 10445). The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:9002179 - 5 mgAvailable on backorder
4′-chloro-α-Pyrrolidinopropiophenone is a halogen-substituted form of the stimulant α-Pyrrolidinopropiophenone (Item No. 10445). The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:9002179 - 50 mgAvailable on backorder
4′-Demethylepipodophyllotoxin is an inhibitor of tubulin polymerization (IC50 = 13 μM).{48556} It inhibits the growth of human HepG2 liver, HeLa cervical, A549 lung, and BGC-823 stomach cancer cells in vitro (IC50s = 18.74, 15.96, 52.08, and 21.26 μM, respectively).{48557} 4′-Demethylepipodophyllotoxin also inhibits the growth of non-cancerous human HL-7702 liver cells (IC50 = 13.04 μM).
Brand:CaymanSKU:28393 - 1 gAvailable on backorder
4′-Demethylepipodophyllotoxin is an inhibitor of tubulin polymerization (IC50 = 13 μM).{48556} It inhibits the growth of human HepG2 liver, HeLa cervical, A549 lung, and BGC-823 stomach cancer cells in vitro (IC50s = 18.74, 15.96, 52.08, and 21.26 μM, respectively).{48557} 4′-Demethylepipodophyllotoxin also inhibits the growth of non-cancerous human HL-7702 liver cells (IC50 = 13.04 μM).
Brand:CaymanSKU:28393 - 10 gAvailable on backorder
4′-Demethylepipodophyllotoxin is an inhibitor of tubulin polymerization (IC50 = 13 μM).{48556} It inhibits the growth of human HepG2 liver, HeLa cervical, A549 lung, and BGC-823 stomach cancer cells in vitro (IC50s = 18.74, 15.96, 52.08, and 21.26 μM, respectively).{48557} 4′-Demethylepipodophyllotoxin also inhibits the growth of non-cancerous human HL-7702 liver cells (IC50 = 13.04 μM).
Brand:CaymanSKU:28393 - 25 gAvailable on backorder
4′-Demethylepipodophyllotoxin is an inhibitor of tubulin polymerization (IC50 = 13 μM).{48556} It inhibits the growth of human HepG2 liver, HeLa cervical, A549 lung, and BGC-823 stomach cancer cells in vitro (IC50s = 18.74, 15.96, 52.08, and 21.26 μM, respectively).{48557} 4′-Demethylepipodophyllotoxin also inhibits the growth of non-cancerous human HL-7702 liver cells (IC50 = 13.04 μM).
Brand:CaymanSKU:28393 - 5 gAvailable on backorder
4′-hydroxy Chalcone is a chalcone metabolite with diverse biological activities. It is formed when chalcone is metabolized by the cytochrome (CYP) P450 isoform CYP1A1 or CYP2C6.{40121} 4′-hydroxy Chalcone is estrogenic in MCF-7 cells and is cytotoxic at concentrations higher than 100 nM. It inhibits TNF-α-induced NF-κB signaling and the trypsin-, chymotrypsin-, and caspase-like proteolytic activities of the 26S proteasome in K562 cells in a dose-dependent manner.{40122} 4′-hydroxy Chalcone reduces growth of K562, U937, and Jurkat cancer cell lines in a dose-dependent manner without effecting viability of peripheral blood mononuclear cells (PBMCs). It also inhibits glutathione reductase (GSH-RD; IC50 = 47.3 μM) in vitro in a reversible and non-competitive manner.{40123}
Brand:CaymanSKU:22898 - 10 gAvailable on backorder
4′-hydroxy Chalcone is a chalcone metabolite with diverse biological activities. It is formed when chalcone is metabolized by the cytochrome (CYP) P450 isoform CYP1A1 or CYP2C6.{40121} 4′-hydroxy Chalcone is estrogenic in MCF-7 cells and is cytotoxic at concentrations higher than 100 nM. It inhibits TNF-α-induced NF-κB signaling and the trypsin-, chymotrypsin-, and caspase-like proteolytic activities of the 26S proteasome in K562 cells in a dose-dependent manner.{40122} 4′-hydroxy Chalcone reduces growth of K562, U937, and Jurkat cancer cell lines in a dose-dependent manner without effecting viability of peripheral blood mononuclear cells (PBMCs). It also inhibits glutathione reductase (GSH-RD; IC50 = 47.3 μM) in vitro in a reversible and non-competitive manner.{40123}
Brand:CaymanSKU:22898 - 25 gAvailable on backorder
4′-hydroxy Chalcone is a chalcone metabolite with diverse biological activities. It is formed when chalcone is metabolized by the cytochrome (CYP) P450 isoform CYP1A1 or CYP2C6.{40121} 4′-hydroxy Chalcone is estrogenic in MCF-7 cells and is cytotoxic at concentrations higher than 100 nM. It inhibits TNF-α-induced NF-κB signaling and the trypsin-, chymotrypsin-, and caspase-like proteolytic activities of the 26S proteasome in K562 cells in a dose-dependent manner.{40122} 4′-hydroxy Chalcone reduces growth of K562, U937, and Jurkat cancer cell lines in a dose-dependent manner without effecting viability of peripheral blood mononuclear cells (PBMCs). It also inhibits glutathione reductase (GSH-RD; IC50 = 47.3 μM) in vitro in a reversible and non-competitive manner.{40123}
Brand:CaymanSKU:22898 - 5 gAvailable on backorder
4′-hydroxy Chalcone is a chalcone metabolite with diverse biological activities. It is formed when chalcone is metabolized by the cytochrome (CYP) P450 isoform CYP1A1 or CYP2C6.{40121} 4′-hydroxy Chalcone is estrogenic in MCF-7 cells and is cytotoxic at concentrations higher than 100 nM. It inhibits TNF-α-induced NF-κB signaling and the trypsin-, chymotrypsin-, and caspase-like proteolytic activities of the 26S proteasome in K562 cells in a dose-dependent manner.{40122} 4′-hydroxy Chalcone reduces growth of K562, U937, and Jurkat cancer cell lines in a dose-dependent manner without effecting viability of peripheral blood mononuclear cells (PBMCs). It also inhibits glutathione reductase (GSH-RD; IC50 = 47.3 μM) in vitro in a reversible and non-competitive manner.{40123}
Brand:CaymanSKU:22898 - 50 gAvailable on backorder
4′-hydroxy Flurbiprofen is a major active metabolite of the COX inhibitor flurbiprofen (Item No. 70250) and its enantiomers (R)-flurbiprofen (Item No. 70255) and (S)-flurbiprofen (Item No. 10004207).{48402} It is formed from flurbiprofen by the cytochrome P450 (CYP) isoform CYP2C9, including CYP2C9 containing an R144C substitution mutation. 4’-hydroxy Flurbiprofen inhibits COX-1 by 94% at a concentration of 1,000 µM but does not inhibit cyclooxygenation of arachidonic acid.{48403} It completely inhibits cyclooxygenation of 2-arachidonoyl glycerol (2-AG; Item No. 62160) when used at a concentration of 300 µM. 4′-hydroxy Flurbiprofen inhibits fatty acid amide hydrolase (FAAH) hydrolysis of anandamide in rat brain homogenates with an IC50 value of 84 µM at a pH of 6.
Brand:CaymanSKU:21691 -Out of stock
4′-hydroxy Flurbiprofen is a major active metabolite of the COX inhibitor flurbiprofen (Item No. 70250) and its enantiomers (R)-flurbiprofen (Item No. 70255) and (S)-flurbiprofen (Item No. 10004207).{48402} It is formed from flurbiprofen by the cytochrome P450 (CYP) isoform CYP2C9, including CYP2C9 containing an R144C substitution mutation. 4’-hydroxy Flurbiprofen inhibits COX-1 by 94% at a concentration of 1,000 µM but does not inhibit cyclooxygenation of arachidonic acid.{48403} It completely inhibits cyclooxygenation of 2-arachidonoyl glycerol (2-AG; Item No. 62160) when used at a concentration of 300 µM. 4′-hydroxy Flurbiprofen inhibits fatty acid amide hydrolase (FAAH) hydrolysis of anandamide in rat brain homogenates with an IC50 value of 84 µM at a pH of 6.
Brand:CaymanSKU:21691 -Out of stock
4′-hydroxy Flurbiprofen is a major active metabolite of the COX inhibitor flurbiprofen (Item No. 70250) and its enantiomers (R)-flurbiprofen (Item No. 70255) and (S)-flurbiprofen (Item No. 10004207).{48402} It is formed from flurbiprofen by the cytochrome P450 (CYP) isoform CYP2C9, including CYP2C9 containing an R144C substitution mutation. 4’-hydroxy Flurbiprofen inhibits COX-1 by 94% at a concentration of 1,000 µM but does not inhibit cyclooxygenation of arachidonic acid.{48403} It completely inhibits cyclooxygenation of 2-arachidonoyl glycerol (2-AG; Item No. 62160) when used at a concentration of 300 µM. 4′-hydroxy Flurbiprofen inhibits fatty acid amide hydrolase (FAAH) hydrolysis of anandamide in rat brain homogenates with an IC50 value of 84 µM at a pH of 6.
Brand:CaymanSKU:21691 -Out of stock
4’-hydroxy Nitazene (Item No. 30218) is an analytical reference standard categorized as an opioid metabolite.{48876} 4’-hydroxy Nitazene is a metabolite of isotonitazene (Item No. 27255). This product is intended for research and forensic applications.
Brand:CaymanSKU:30218 - 1 mgAvailable on backorder
4’-hydroxy Nitazene (Item No. 30218) is an analytical reference standard categorized as an opioid metabolite.{48876} 4’-hydroxy Nitazene is a metabolite of isotonitazene (Item No. 27255). This product is intended for research and forensic applications.
Brand:CaymanSKU:30218 - 5 mgAvailable on backorder
4’-hydroxyphenyl Carvedilol is a metabolite of carvedilol (Item No. 15418) that is a more potent β-adrenergic receptor antagonist than carvedilol but has weaker vasodilatory activity.{49062} It is formed through oxidation primarily by the cytochrome P450 (CYP) isoform CYP2D6.{49063} 4’-hydroxyphenyl Carvedilol inhibits the formation of DPPH radicals in a cell-free assay.{49064}
Brand:CaymanSKU:27172 - 1 mgAvailable on backorder
4’-hydroxyphenyl Carvedilol is a metabolite of carvedilol (Item No. 15418) that is a more potent β-adrenergic receptor antagonist than carvedilol but has weaker vasodilatory activity.{49062} It is formed through oxidation primarily by the cytochrome P450 (CYP) isoform CYP2D6.{49063} 4’-hydroxyphenyl Carvedilol inhibits the formation of DPPH radicals in a cell-free assay.{49064}
Brand:CaymanSKU:27172 - 5 mgAvailable on backorder
Pyrrolidinophenones (PPPs) are a family of compounds that feature a pyrrolidinyl group affixed to the narcotic cathinone. Many have been identified as components of designer drugs.{19508} 4’-methyl-α-PPP (hydrochloride) shares structural features with the stimulant α-PPP and has been detected in bath salts and other formulations.{19508,19193} The metabolism of 4’-methyl-α-PPP has been characterized.{19755,19737} This product is intended to be used for forensic applications.
Brand:CaymanSKU:-
4′-O-methyl Quercetin is a flavonoid isolated from C. ordata with anticancer and antiplasmodial activity. 4′-O-methyl Quercetin is a major metabolite of quercetin (Item No. 10005169) that inhibits the viability of HL-60, U937, MOLT-3, Raji, K562, MCF-7, SK-MEL-1, and A549 human tumor cell lines with IC50 values ranging from 5.5-24.1 μM.{39035} It induces G2-M arrest and inhibits tubulin polymerization in vitro in a dose-dependent manner. 4′-O-methyl Quercetin inhibits breast cancer resistance protein (BCRP/ABCG2; IC50 = 40 nM in a vesicular transport assay) with no cellular toxicity indicating potential for use in overcoming multidrug resistance in chemotherapy.{39036} 4′-O-methyl Quercetin also reduces in vitro proliferation of chloroquine-resistant P. falciparum (IC50 = 4.8 μM) and suppresses infection in mice (65-81% suppression at 2.5-5 mg/kg dose).{39037}
Brand:CaymanSKU:22406 -Out of stock
4′-O-methyl Quercetin is a flavonoid isolated from C. ordata with anticancer and antiplasmodial activity. 4′-O-methyl Quercetin is a major metabolite of quercetin (Item No. 10005169) that inhibits the viability of HL-60, U937, MOLT-3, Raji, K562, MCF-7, SK-MEL-1, and A549 human tumor cell lines with IC50 values ranging from 5.5-24.1 μM.{39035} It induces G2-M arrest and inhibits tubulin polymerization in vitro in a dose-dependent manner. 4′-O-methyl Quercetin inhibits breast cancer resistance protein (BCRP/ABCG2; IC50 = 40 nM in a vesicular transport assay) with no cellular toxicity indicating potential for use in overcoming multidrug resistance in chemotherapy.{39036} 4′-O-methyl Quercetin also reduces in vitro proliferation of chloroquine-resistant P. falciparum (IC50 = 4.8 μM) and suppresses infection in mice (65-81% suppression at 2.5-5 mg/kg dose).{39037}
Brand:CaymanSKU:22406 -Out of stock
4′-O-methyl Quercetin is a flavonoid isolated from C. ordata with anticancer and antiplasmodial activity. 4′-O-methyl Quercetin is a major metabolite of quercetin (Item No. 10005169) that inhibits the viability of HL-60, U937, MOLT-3, Raji, K562, MCF-7, SK-MEL-1, and A549 human tumor cell lines with IC50 values ranging from 5.5-24.1 μM.{39035} It induces G2-M arrest and inhibits tubulin polymerization in vitro in a dose-dependent manner. 4′-O-methyl Quercetin inhibits breast cancer resistance protein (BCRP/ABCG2; IC50 = 40 nM in a vesicular transport assay) with no cellular toxicity indicating potential for use in overcoming multidrug resistance in chemotherapy.{39036} 4′-O-methyl Quercetin also reduces in vitro proliferation of chloroquine-resistant P. falciparum (IC50 = 4.8 μM) and suppresses infection in mice (65-81% suppression at 2.5-5 mg/kg dose).{39037}
Brand:CaymanSKU:22406 -Out of stock
4′-O-methyl Quercetin is a flavonoid isolated from C. ordata with anticancer and antiplasmodial activity. 4′-O-methyl Quercetin is a major metabolite of quercetin (Item No. 10005169) that inhibits the viability of HL-60, U937, MOLT-3, Raji, K562, MCF-7, SK-MEL-1, and A549 human tumor cell lines with IC50 values ranging from 5.5-24.1 μM.{39035} It induces G2-M arrest and inhibits tubulin polymerization in vitro in a dose-dependent manner. 4′-O-methyl Quercetin inhibits breast cancer resistance protein (BCRP/ABCG2; IC50 = 40 nM in a vesicular transport assay) with no cellular toxicity indicating potential for use in overcoming multidrug resistance in chemotherapy.{39036} 4′-O-methyl Quercetin also reduces in vitro proliferation of chloroquine-resistant P. falciparum (IC50 = 4.8 μM) and suppresses infection in mice (65-81% suppression at 2.5-5 mg/kg dose).{39037}
Brand:CaymanSKU:22406 -Out of stock
4′-O-Methylhonokiol is a phenol that has been found in M. grandiflora and has diverse biological activities.{58070,58073,58071,58072} It is active against the bacteria B. subtilis, S. aureus, and M. smegmatis (MIC = 2.5 µg/ml for all) and the fungus T. mentagrophytes (MIC = 1.25 µg/ml).{58070} 4′-O-Methylhonokiol (10 and 30 µM) inhibits LPS-induced activation of NF-kB and production of nitric oxide (NO) in RAW 264.7 macrophages.{58073} In vivo, 4′-O-Methylhonokiol (20 and 200 mg/kg) reduces carrageenan-induced paw edema in mice. It reduces neuronal apoptosis and escape latency in the Morris water maze in a mouse model of Alzheimer’s disease induced by amyloid-β 1-42 (Aβ42) when administered at a dose of 1 mg/kg.{58071} 4-O-methylhonokiol also reduces plasma cholesterol and triglyceride levels, ameliorates hepatic steatosis, and improves insulin resistance in a mouse model of high-fat diet-induced obesity.{58072}
Brand:CaymanSKU:11089 - 1 mgAvailable on backorder
4′-O-Methylhonokiol is a phenol that has been found in M. grandiflora and has diverse biological activities.{58070,58073,58071,58072} It is active against the bacteria B. subtilis, S. aureus, and M. smegmatis (MIC = 2.5 µg/ml for all) and the fungus T. mentagrophytes (MIC = 1.25 µg/ml).{58070} 4′-O-Methylhonokiol (10 and 30 µM) inhibits LPS-induced activation of NF-kB and production of nitric oxide (NO) in RAW 264.7 macrophages.{58073} In vivo, 4′-O-Methylhonokiol (20 and 200 mg/kg) reduces carrageenan-induced paw edema in mice. It reduces neuronal apoptosis and escape latency in the Morris water maze in a mouse model of Alzheimer’s disease induced by amyloid-β 1-42 (Aβ42) when administered at a dose of 1 mg/kg.{58071} 4-O-methylhonokiol also reduces plasma cholesterol and triglyceride levels, ameliorates hepatic steatosis, and improves insulin resistance in a mouse model of high-fat diet-induced obesity.{58072}
Brand:CaymanSKU:11089 - 10 mgAvailable on backorder
4′-O-Methylhonokiol is a phenol that has been found in M. grandiflora and has diverse biological activities.{58070,58073,58071,58072} It is active against the bacteria B. subtilis, S. aureus, and M. smegmatis (MIC = 2.5 µg/ml for all) and the fungus T. mentagrophytes (MIC = 1.25 µg/ml).{58070} 4′-O-Methylhonokiol (10 and 30 µM) inhibits LPS-induced activation of NF-kB and production of nitric oxide (NO) in RAW 264.7 macrophages.{58073} In vivo, 4′-O-Methylhonokiol (20 and 200 mg/kg) reduces carrageenan-induced paw edema in mice. It reduces neuronal apoptosis and escape latency in the Morris water maze in a mouse model of Alzheimer’s disease induced by amyloid-β 1-42 (Aβ42) when administered at a dose of 1 mg/kg.{58071} 4-O-methylhonokiol also reduces plasma cholesterol and triglyceride levels, ameliorates hepatic steatosis, and improves insulin resistance in a mouse model of high-fat diet-induced obesity.{58072}
Brand:CaymanSKU:11089 - 5 mgAvailable on backorder
4′-O-Methylhonokiol is a phenol that has been found in M. grandiflora and has diverse biological activities.{58070,58073,58071,58072} It is active against the bacteria B. subtilis, S. aureus, and M. smegmatis (MIC = 2.5 µg/ml for all) and the fungus T. mentagrophytes (MIC = 1.25 µg/ml).{58070} 4′-O-Methylhonokiol (10 and 30 µM) inhibits LPS-induced activation of NF-kB and production of nitric oxide (NO) in RAW 264.7 macrophages.{58073} In vivo, 4′-O-Methylhonokiol (20 and 200 mg/kg) reduces carrageenan-induced paw edema in mice. It reduces neuronal apoptosis and escape latency in the Morris water maze in a mouse model of Alzheimer’s disease induced by amyloid-β 1-42 (Aβ42) when administered at a dose of 1 mg/kg.{58071} 4-O-methylhonokiol also reduces plasma cholesterol and triglyceride levels, ameliorates hepatic steatosis, and improves insulin resistance in a mouse model of high-fat diet-induced obesity.{58072}
Brand:CaymanSKU:11089 - 500 µgAvailable on backorder
4’-O-Methylresveratrol is a stilbene that has been found in Rumex and has diverse biological activities.{49468,49469,49470,49471} It inhibits growth of A549, SKOV3, SK-MEL-2, XF498, and HCT15 cancer cells (IC50s = 3.8, 5.7, 3.2, 5.6, and 6.7 µg/ml, respectively).{49468} 4’-O-Methylresveratrol (0.05-0.2 mM) inhibits rabbit platelet aggregation induced by collagen or arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607).{49469} It scavenges free radicals in a Trolox equivalent antioxidant capacity (TEAC) assay.{49470} 4’-O-Methyresveratrol suppresses RANKL-induced osteoclastic differentiation of murine bone marrow-derived macrophages (BMDMs) and reduces LPS-induced bone loss in mice when administered at a dose of 50 mg/kg.{49471}
Brand:CaymanSKU:29106 - 10 mgAvailable on backorder
4’-O-Methylresveratrol is a stilbene that has been found in Rumex and has diverse biological activities.{49468,49469,49470,49471} It inhibits growth of A549, SKOV3, SK-MEL-2, XF498, and HCT15 cancer cells (IC50s = 3.8, 5.7, 3.2, 5.6, and 6.7 µg/ml, respectively).{49468} 4’-O-Methylresveratrol (0.05-0.2 mM) inhibits rabbit platelet aggregation induced by collagen or arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607).{49469} It scavenges free radicals in a Trolox equivalent antioxidant capacity (TEAC) assay.{49470} 4’-O-Methyresveratrol suppresses RANKL-induced osteoclastic differentiation of murine bone marrow-derived macrophages (BMDMs) and reduces LPS-induced bone loss in mice when administered at a dose of 50 mg/kg.{49471}
Brand:CaymanSKU:29106 - 25 mgAvailable on backorder
4’-O-Methylresveratrol is a stilbene that has been found in Rumex and has diverse biological activities.{49468,49469,49470,49471} It inhibits growth of A549, SKOV3, SK-MEL-2, XF498, and HCT15 cancer cells (IC50s = 3.8, 5.7, 3.2, 5.6, and 6.7 µg/ml, respectively).{49468} 4’-O-Methylresveratrol (0.05-0.2 mM) inhibits rabbit platelet aggregation induced by collagen or arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607).{49469} It scavenges free radicals in a Trolox equivalent antioxidant capacity (TEAC) assay.{49470} 4’-O-Methyresveratrol suppresses RANKL-induced osteoclastic differentiation of murine bone marrow-derived macrophages (BMDMs) and reduces LPS-induced bone loss in mice when administered at a dose of 50 mg/kg.{49471}
Brand:CaymanSKU:29106 - 5 mgAvailable on backorder
4’-O-Methylresveratrol is a stilbene that has been found in Rumex and has diverse biological activities.{49468,49469,49470,49471} It inhibits growth of A549, SKOV3, SK-MEL-2, XF498, and HCT15 cancer cells (IC50s = 3.8, 5.7, 3.2, 5.6, and 6.7 µg/ml, respectively).{49468} 4’-O-Methylresveratrol (0.05-0.2 mM) inhibits rabbit platelet aggregation induced by collagen or arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607).{49469} It scavenges free radicals in a Trolox equivalent antioxidant capacity (TEAC) assay.{49470} 4’-O-Methyresveratrol suppresses RANKL-induced osteoclastic differentiation of murine bone marrow-derived macrophages (BMDMs) and reduces LPS-induced bone loss in mice when administered at a dose of 50 mg/kg.{49471}
Brand:CaymanSKU:29106 - 50 mgAvailable on backorder
4’-hydroxy Tamoxifen is one of five main phase I metabolites of tamoxifen (Item No. 13258), a well-known estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium. 4’-hydroxy Tamoxifen is a product of cytochrome P450 (CYP)2D6 and CYP2B6 activity.{31466,28446,31468} With the addition of a hydroxyl group, 4’-hydroxy tamoxifen has been shown to have a higher affinity for estrogen receptors compared to tamoxifen.{31469} At 10-100 µM, 4’-hydroxy tamoxifen is cytotoxic, in a non-apoptotic manner, to HEC-1B and HEC-1A human endometrial adenocarcinoma cell lines.{31467}
Brand:CaymanSKU:-Available on backorder
4’-hydroxy Tamoxifen is one of five main phase I metabolites of tamoxifen (Item No. 13258), a well-known estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium. 4’-hydroxy Tamoxifen is a product of cytochrome P450 (CYP)2D6 and CYP2B6 activity.{31466,28446,31468} With the addition of a hydroxyl group, 4’-hydroxy tamoxifen has been shown to have a higher affinity for estrogen receptors compared to tamoxifen.{31469} At 10-100 µM, 4’-hydroxy tamoxifen is cytotoxic, in a non-apoptotic manner, to HEC-1B and HEC-1A human endometrial adenocarcinoma cell lines.{31467}
Brand:CaymanSKU:-Available on backorder
4’-methoxy-α-Ethylaminovalerophenone (hydrochloride) (Item No. 19275) is an analytical reference standard that is structurally classified as a cathinone. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research uses.
Brand:CaymanSKU:-Available on backorder
4’-methoxy-α-Ethylaminovalerophenone (hydrochloride) (Item No. 19275) is an analytical reference standard that is structurally classified as a cathinone. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research uses.
Brand:CaymanSKU:-Available on backorder
4(Z),7(Z)-Decadienoic acid is a polyunsaturated fatty acid (PUFA).{40631} It is increased in the plasma of patients with a medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, a fatty acid oxidation disorder.
Brand:CaymanSKU:23516 - 1 mgAvailable on backorder
4(Z),7(Z)-Decadienoic acid is a polyunsaturated fatty acid (PUFA).{40631} It is increased in the plasma of patients with a medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, a fatty acid oxidation disorder.
Brand:CaymanSKU:23516 - 10 mgAvailable on backorder
4(Z),7(Z)-Decadienoic acid is a polyunsaturated fatty acid (PUFA).{40631} It is increased in the plasma of patients with a medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, a fatty acid oxidation disorder.
Brand:CaymanSKU:23516 - 25 mgAvailable on backorder
4(Z),7(Z)-Decadienoic acid is a polyunsaturated fatty acid (PUFA).{40631} It is increased in the plasma of patients with a medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, a fatty acid oxidation disorder.
Brand:CaymanSKU:23516 - 5 mgAvailable on backorder
4(Z),7(Z),10(Z),13(Z)-Hexadecatetraenoic acid is an unusual polyunsaturated fatty acid (PUFA) generated during the synthesis of docosahexaenoic acid-d5 (Item No. 10005057). While the physiological properties of this compound are not known, dietary intake of n-3 long-chain PUFAs provides potential health benefits.{22300}
Brand:CaymanSKU:9002202 - 100 µgAvailable on backorder
4(Z),7(Z),10(Z),13(Z)-Hexadecatetraenoic acid is an unusual polyunsaturated fatty acid (PUFA) generated during the synthesis of docosahexaenoic acid-d5 (Item No. 10005057). While the physiological properties of this compound are not known, dietary intake of n-3 long-chain PUFAs provides potential health benefits.{22300}
Brand:CaymanSKU:9002202 - 50 µgAvailable on backorder
4(Z),7(Z),10(Z),13(Z)-Hexadecatetraenoic acid is an unusual polyunsaturated fatty acid (PUFA) generated during the synthesis of docosahexaenoic acid-d5 (Item No. 10005057). While the physiological properties of this compound are not known, dietary intake of n-3 long-chain PUFAs provides potential health benefits.{22300}
Brand:CaymanSKU:9002202 - 500 µgAvailable on backorder
4(Z),7(Z),10(Z),13(Z)-Hexadecatetraenoic acid methyl ester is the methyl ester version of an unusual polyunsaturated fatty acid (PUFA) generated during the synthesis of docosahexaenoic acid-d5 (Item No. 10005057). While the physiological properties of this compound are not known, dietary intake of n-3 long-chain PUFAs provides potential health benefits.{22300}
Brand:CaymanSKU:9002661 - 100 µgAvailable on backorder
4(Z),7(Z),10(Z),13(Z)-Hexadecatetraenoic acid methyl ester is the methyl ester version of an unusual polyunsaturated fatty acid (PUFA) generated during the synthesis of docosahexaenoic acid-d5 (Item No. 10005057). While the physiological properties of this compound are not known, dietary intake of n-3 long-chain PUFAs provides potential health benefits.{22300}
Brand:CaymanSKU:9002661 - 50 µgAvailable on backorder
4(Z),7(Z),10(Z),13(Z)-Hexadecatetraenoic acid methyl ester is the methyl ester version of an unusual polyunsaturated fatty acid (PUFA) generated during the synthesis of docosahexaenoic acid-d5 (Item No. 10005057). While the physiological properties of this compound are not known, dietary intake of n-3 long-chain PUFAs provides potential health benefits.{22300}
Brand:CaymanSKU:9002661 - 500 µgAvailable on backorder
4(Z),7(Z),10(Z),13(Z),16(Z)-N-(2-hydroxyethyl)-Docosapentaenamide is a long-chain ω-6 fatty acid with a hydroxyethylamide group attached at the alpha chain.
Brand:CaymanSKU:- 4(Z),7(Z),10(Z),13(Z),16(Z)-N-(2-hydroxyethyl)-Docosapentaenamide is a long-chain ω-6 fatty acid with a hydroxyethylamide group attached at the alpha chain.
Brand:CaymanSKU:- 4(Z),7(Z),10(Z),13(Z),16(Z)-N-(2-hydroxyethyl)-Docosapentaenamide is a long-chain ω-6 fatty acid with a hydroxyethylamide group attached at the alpha chain.
Brand:CaymanSKU:-
4(Z),7(Z),10(Z),13(Z),16(Z)-Nonadecapentaenoic acid is an unusual polyunsaturated fatty acid (PUFA) generated during the synthesis of docosahexaenoic acid-d5 (Item No. 10005057). While the physiological properties of this compound are not known, dietary intake of n-3 long-chain PUFAs provides potential health benefits.{22300}
Brand:CaymanSKU:-Available on backorder
4(Z),7(Z),10(Z),13(Z),16(Z)-Nonadecapentaenoic acid is an unusual polyunsaturated fatty acid (PUFA) generated during the synthesis of docosahexaenoic acid-d5 (Item No. 10005057). While the physiological properties of this compound are not known, dietary intake of n-3 long-chain PUFAs provides potential health benefits.{22300}
Brand:CaymanSKU:-Available on backorder
4(Z),7(Z),10(Z),13(Z),16(Z)-Nonadecapentaenoic acid is an unusual polyunsaturated fatty acid (PUFA) generated during the synthesis of docosahexaenoic acid-d5 (Item No. 10005057). While the physiological properties of this compound are not known, dietary intake of n-3 long-chain PUFAs provides potential health benefits.{22300}
Brand:CaymanSKU:-Available on backorder
4(Z),7(Z),10(Z),13(Z),16(Z)-Nonadecapentaenoic acid is an unusual polyunsaturated fatty acid (PUFA) generated during the synthesis of docosahexaenoic acid-d5 (Item No. 10005057). While the physiological properties of this compound are not known, dietary intake of n-3 long-chain PUFAs provides potential health benefits.{22300}
Brand:CaymanSKU:-Available on backorder
4BP-TQS is an allosteric agonist of α7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs).{47588} It activates human α7 subunit-containing nAChRs expressed in X. laevis oocytes more potently than acetylcholine (Item No. 23829; EC50s = 17 and 128 µM, respectively). It is selective for α7 subunit-containing nAChRs, having no activity for α1β1δε-, α3β4-, and α4β2 subunit-containing nAChRs at 100 µM.{47589} 4BP-TQS (10 µM) potentiates acetylcholine-induced activation of α7 subunit-containing nAChRs by greater than 540-fold in X. laevis oocytes.{47588} It activates wild-type α7 subunit-containing nAChRs and nAChRs containing the α7 subunit and W148F, but not M253L, mutations in X. laevis oocytes.
Brand:CaymanSKU:21881 -Out of stock
4BP-TQS is an allosteric agonist of α7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs).{47588} It activates human α7 subunit-containing nAChRs expressed in X. laevis oocytes more potently than acetylcholine (Item No. 23829; EC50s = 17 and 128 µM, respectively). It is selective for α7 subunit-containing nAChRs, having no activity for α1β1δε-, α3β4-, and α4β2 subunit-containing nAChRs at 100 µM.{47589} 4BP-TQS (10 µM) potentiates acetylcholine-induced activation of α7 subunit-containing nAChRs by greater than 540-fold in X. laevis oocytes.{47588} It activates wild-type α7 subunit-containing nAChRs and nAChRs containing the α7 subunit and W148F, but not M253L, mutations in X. laevis oocytes.
Brand:CaymanSKU:21881 -Out of stock
4BP-TQS is an allosteric agonist of α7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs).{47588} It activates human α7 subunit-containing nAChRs expressed in X. laevis oocytes more potently than acetylcholine (Item No. 23829; EC50s = 17 and 128 µM, respectively). It is selective for α7 subunit-containing nAChRs, having no activity for α1β1δε-, α3β4-, and α4β2 subunit-containing nAChRs at 100 µM.{47589} 4BP-TQS (10 µM) potentiates acetylcholine-induced activation of α7 subunit-containing nAChRs by greater than 540-fold in X. laevis oocytes.{47588} It activates wild-type α7 subunit-containing nAChRs and nAChRs containing the α7 subunit and W148F, but not M253L, mutations in X. laevis oocytes.
Brand:CaymanSKU:21881 -Out of stock
4BP-TQS is an allosteric agonist of α7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs).{47588} It activates human α7 subunit-containing nAChRs expressed in X. laevis oocytes more potently than acetylcholine (Item No. 23829; EC50s = 17 and 128 µM, respectively). It is selective for α7 subunit-containing nAChRs, having no activity for α1β1δε-, α3β4-, and α4β2 subunit-containing nAChRs at 100 µM.{47589} 4BP-TQS (10 µM) potentiates acetylcholine-induced activation of α7 subunit-containing nAChRs by greater than 540-fold in X. laevis oocytes.{47588} It activates wild-type α7 subunit-containing nAChRs and nAChRs containing the α7 subunit and W148F, but not M253L, mutations in X. laevis oocytes.
Brand:CaymanSKU:21881 -Out of stock
4E1RCat is an inhibitor of the eIF4F translation initiation complex that blocks eIF4E:eIF4G and eIF4E:4E-BP1 interactions.{31602} It has been shown to prevent the assembly of the eIF4F complex and to inhibit cap-dependent translation with an IC50 value of ~4 μM.{31602} 4E1RCat was shown to reverse tumor chemoresistance in a mouse model of lymphoma by sensitizing cells to the proapoptotic action of DNA damage.{31602}
Brand:CaymanSKU:-Available on backorder
4E1RCat is an inhibitor of the eIF4F translation initiation complex that blocks eIF4E:eIF4G and eIF4E:4E-BP1 interactions.{31602} It has been shown to prevent the assembly of the eIF4F complex and to inhibit cap-dependent translation with an IC50 value of ~4 μM.{31602} 4E1RCat was shown to reverse tumor chemoresistance in a mouse model of lymphoma by sensitizing cells to the proapoptotic action of DNA damage.{31602}
Brand:CaymanSKU:-Available on backorder
4E1RCat is an inhibitor of the eIF4F translation initiation complex that blocks eIF4E:eIF4G and eIF4E:4E-BP1 interactions.{31602} It has been shown to prevent the assembly of the eIF4F complex and to inhibit cap-dependent translation with an IC50 value of ~4 μM.{31602} 4E1RCat was shown to reverse tumor chemoresistance in a mouse model of lymphoma by sensitizing cells to the proapoptotic action of DNA damage.{31602}
Brand:CaymanSKU:-Available on backorder
In eukaryotes, a set of initiation factors (eIFs) interact with ribosomal subunits to initiate mRNA translation.{25211} A major step in initiation is the assembly of a large multiprotein complex that includes the cap-binding protein eIF4E and the multidomain adaptor protein eIF4G.{25211} 4EGI-1 is an inhibitor of the initiation of translation that blocks the interaction of eIF4G with eIF4E (KD = 25 μM).{25208} It directly binds eIF4E, competitively inhibiting an association with eIF4G that is necessary for cap-dependent translation.{25208} 4EGI-1 prevents the expression of oncogenic proteins in mammalian cancer cells, leading to apoptosis.{25208,25207,25213} Research with this inhibitor supports a role for normal eIF4E/eIF4G interaction in memory consolidation and excess interaction in autism spectrum disorders.{25212,25210,25206} 4EGI-1 also blocks translation in some viruses that do not require eIF4E or a cap structure for initiation.{25209}
Brand:CaymanSKU:- In eukaryotes, a set of initiation factors (eIFs) interact with ribosomal subunits to initiate mRNA translation.{25211} A major step in initiation is the assembly of a large multiprotein complex that includes the cap-binding protein eIF4E and the multidomain adaptor protein eIF4G.{25211} 4EGI-1 is an inhibitor of the initiation of translation that blocks the interaction of eIF4G with eIF4E (KD = 25 μM).{25208} It directly binds eIF4E, competitively inhibiting an association with eIF4G that is necessary for cap-dependent translation.{25208} 4EGI-1 prevents the expression of oncogenic proteins in mammalian cancer cells, leading to apoptosis.{25208,25207,25213} Research with this inhibitor supports a role for normal eIF4E/eIF4G interaction in memory consolidation and excess interaction in autism spectrum disorders.{25212,25210,25206} 4EGI-1 also blocks translation in some viruses that do not require eIF4E or a cap structure for initiation.{25209}
Brand:CaymanSKU:- In eukaryotes, a set of initiation factors (eIFs) interact with ribosomal subunits to initiate mRNA translation.{25211} A major step in initiation is the assembly of a large multiprotein complex that includes the cap-binding protein eIF4E and the multidomain adaptor protein eIF4G.{25211} 4EGI-1 is an inhibitor of the initiation of translation that blocks the interaction of eIF4G with eIF4E (KD = 25 μM).{25208} It directly binds eIF4E, competitively inhibiting an association with eIF4G that is necessary for cap-dependent translation.{25208} 4EGI-1 prevents the expression of oncogenic proteins in mammalian cancer cells, leading to apoptosis.{25208,25207,25213} Research with this inhibitor supports a role for normal eIF4E/eIF4G interaction in memory consolidation and excess interaction in autism spectrum disorders.{25212,25210,25206} 4EGI-1 also blocks translation in some viruses that do not require eIF4E or a cap structure for initiation.{25209}
Brand:CaymanSKU:- In eukaryotes, a set of initiation factors (eIFs) interact with ribosomal subunits to initiate mRNA translation.{25211} A major step in initiation is the assembly of a large multiprotein complex that includes the cap-binding protein eIF4E and the multidomain adaptor protein eIF4G.{25211} 4EGI-1 is an inhibitor of the initiation of translation that blocks the interaction of eIF4G with eIF4E (KD = 25 μM).{25208} It directly binds eIF4E, competitively inhibiting an association with eIF4G that is necessary for cap-dependent translation.{25208} 4EGI-1 prevents the expression of oncogenic proteins in mammalian cancer cells, leading to apoptosis.{25208,25207,25213} Research with this inhibitor supports a role for normal eIF4E/eIF4G interaction in memory consolidation and excess interaction in autism spectrum disorders.{25212,25210,25206} 4EGI-1 also blocks translation in some viruses that do not require eIF4E or a cap structure for initiation.{25209}
Brand:CaymanSKU:-
4SC-202 is an inhibitor of the class I histone deacetylases (HDACs) HDAC1-3 and the histone demethylase KDM1A.{48065} It reduces cell viability in a panel of colorectal cancer (CRC) cell lines when used at concentrations ranging from 1 to 10 µM and in patient-derived CRC cell lines when used at a concentration of 5 µM.{48066} 4SC-202 (5 µM) induces cell cycle arrest at the G2/M phase in HT-29 cells and primary human CRC cells and increases apoptosis in HT-29 cells in a concentration-dependent manner, an effect that is enhanced by the Akt inhibitors perifosine (Item No. 10008112) and MK-2206 (Item No. 11593). 4SC-202 (100 mg/kg, p.o., every other day) reduces tumor growth in an HT-29 mouse xenograft model when administered alone and to an enhanced degree when co-administered with oxaliplatin (Item No. 13106).
Brand:CaymanSKU:26175 - 10 mgAvailable on backorder
4SC-202 is an inhibitor of the class I histone deacetylases (HDACs) HDAC1-3 and the histone demethylase KDM1A.{48065} It reduces cell viability in a panel of colorectal cancer (CRC) cell lines when used at concentrations ranging from 1 to 10 µM and in patient-derived CRC cell lines when used at a concentration of 5 µM.{48066} 4SC-202 (5 µM) induces cell cycle arrest at the G2/M phase in HT-29 cells and primary human CRC cells and increases apoptosis in HT-29 cells in a concentration-dependent manner, an effect that is enhanced by the Akt inhibitors perifosine (Item No. 10008112) and MK-2206 (Item No. 11593). 4SC-202 (100 mg/kg, p.o., every other day) reduces tumor growth in an HT-29 mouse xenograft model when administered alone and to an enhanced degree when co-administered with oxaliplatin (Item No. 13106).
Brand:CaymanSKU:26175 - 25 mgAvailable on backorder
4SC-202 is an inhibitor of the class I histone deacetylases (HDACs) HDAC1-3 and the histone demethylase KDM1A.{48065} It reduces cell viability in a panel of colorectal cancer (CRC) cell lines when used at concentrations ranging from 1 to 10 µM and in patient-derived CRC cell lines when used at a concentration of 5 µM.{48066} 4SC-202 (5 µM) induces cell cycle arrest at the G2/M phase in HT-29 cells and primary human CRC cells and increases apoptosis in HT-29 cells in a concentration-dependent manner, an effect that is enhanced by the Akt inhibitors perifosine (Item No. 10008112) and MK-2206 (Item No. 11593). 4SC-202 (100 mg/kg, p.o., every other day) reduces tumor growth in an HT-29 mouse xenograft model when administered alone and to an enhanced degree when co-administered with oxaliplatin (Item No. 13106).
Brand:CaymanSKU:26175 - 5 mgAvailable on backorder
4SC-202 is an inhibitor of the class I histone deacetylases (HDACs) HDAC1-3 and the histone demethylase KDM1A.{48065} It reduces cell viability in a panel of colorectal cancer (CRC) cell lines when used at concentrations ranging from 1 to 10 µM and in patient-derived CRC cell lines when used at a concentration of 5 µM.{48066} 4SC-202 (5 µM) induces cell cycle arrest at the G2/M phase in HT-29 cells and primary human CRC cells and increases apoptosis in HT-29 cells in a concentration-dependent manner, an effect that is enhanced by the Akt inhibitors perifosine (Item No. 10008112) and MK-2206 (Item No. 11593). 4SC-202 (100 mg/kg, p.o., every other day) reduces tumor growth in an HT-29 mouse xenograft model when administered alone and to an enhanced degree when co-administered with oxaliplatin (Item No. 13106).
Brand:CaymanSKU:26175 - 50 mgAvailable on backorder
Phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) is a phorbol ester that is commonly used to activate certain types of PKC, including group A (α, βI, βII, γ) and group B (δ, ε, η, θ) isoforms.{17804} 4α-PMA is a structural analog of PMA that does not activate PKC.{27366,27365} It is used as a negative control for PMA signaling through PKC.{27365}
Brand:CaymanSKU:-Out of stock
4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation.{31450} It is formed from cholesterol by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5.{31450} 4β-hydroxy Cholesterol has an unusually long half-life in plasma (~60 hours) as a result of slow elimination, particularly due to a slow rate of 7α-hydroxylation, which is the rate-limiting step for further conversion into bile acids.
Brand:CaymanSKU:-Available on backorder
4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation.{31450} It is formed from cholesterol by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5.{31450} 4β-hydroxy Cholesterol has an unusually long half-life in plasma (~60 hours) as a result of slow elimination, particularly due to a slow rate of 7α-hydroxylation, which is the rate-limiting step for further conversion into bile acids.
Brand:CaymanSKU:-Available on backorder
4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation.{31450} It is formed from cholesterol by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5.{31450} 4β-hydroxy Cholesterol has an unusually long half-life in plasma (~60 hours) as a result of slow elimination, particularly due to a slow rate of 7α-hydroxylation, which is the rate-limiting step for further conversion into bile acids.
Brand:CaymanSKU:-Available on backorder
4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation.{31450} It is formed from cholesterol by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5.{31450} 4β-hydroxy Cholesterol has an unusually long half-life in plasma (~60 hours) as a result of slow elimination, particularly due to a slow rate of 7α-hydroxylation, which is the rate-limiting step for further conversion into bile acids.
Brand:CaymanSKU:-Available on backorder
4β-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 4β-hydroxy cholesterol (Item No. 19518) by GC- or LC-MS. 4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation.{31450} It is formed from cholesterol by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5.{31450} 4β-hydroxy Cholesterol has an unusually long half-life in plasma (~60 hours) as a result of slow elimination, particularly due to a slow rate of 7α-hydroxylation, which is the rate-limiting step for further conversion into bile acids.
Brand:CaymanSKU:25971 - 1 mgAvailable on backorder
4β-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 4β-hydroxy cholesterol (Item No. 19518) by GC- or LC-MS. 4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation.{31450} It is formed from cholesterol by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5.{31450} 4β-hydroxy Cholesterol has an unusually long half-life in plasma (~60 hours) as a result of slow elimination, particularly due to a slow rate of 7α-hydroxylation, which is the rate-limiting step for further conversion into bile acids.
Brand:CaymanSKU:25971 - 500 µgAvailable on backorder
4β-Hydroxywithanolide E is a withanolide steroidal lactone that has been found in P. peruviana and has anti-inflammatory and anticancer activities.{47526,47527,47528} It inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 cells and TNF-α-induced NF-κB activity in HEK293 cells (IC50s = 0.32 and 0.04 μM, respectively).{47526} 4β-Hydroxywithanolide E (5 μM) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) and COX-2 levels and Akt and STAT1 phosphorylation in RAW 264.7 cells.{47527} It inhibits Wnt signaling in HCT116 and SW480 colorectal cancer cells (IC50s = 1.85 and 2.67 μM, respectively).{47528} 4β-Hydroxywithanolide E inhibits the proliferation of HCT116, SW480, HT-29, and LoVo cells (IC50s = 0.24-0.51 μM). It halts the cell cycle at the G0/G1 phase in HCT116 and HT-29 cells and induces apoptosis in HCT116 and SW480 cells in a concentration-dependent manner. 4β-Hydroxywithanolide E (10 mg/kg per day for 14 days) reduces tumor growth in an HCT116 mouse xenograft model.
Brand:CaymanSKU:27245 - 1 mgAvailable on backorder
4µ8C is an inhibitor of inositol requiring enzyme 1 α (IRE1α), which is a protein located in the endoplasmic reticulum (ER) membrane that has kinase and RNase activities triggered by ER stress.{39181} 4µ8C inhibits IRE1α splicing of Xbp1 mRNA (IC50 = 6.8 µM) and reduces subsequent gene expression of Erdj4 (IC50 = 3.4 µM) in stress-cultured MEF cells but does not block IRE1α autophosphorylation. It reduces IL-4 production in CD4+ T cells isolated from murine spleen and LPS-stimulated increases in TNF-α and IL-6 mRNA expression and protein secretion in isolated alveolar macrophages from patients with cystic fibrosis.{39182,39183}
Brand:CaymanSKU:22110 -Out of stock
4µ8C is an inhibitor of inositol requiring enzyme 1 α (IRE1α), which is a protein located in the endoplasmic reticulum (ER) membrane that has kinase and RNase activities triggered by ER stress.{39181} 4µ8C inhibits IRE1α splicing of Xbp1 mRNA (IC50 = 6.8 µM) and reduces subsequent gene expression of Erdj4 (IC50 = 3.4 µM) in stress-cultured MEF cells but does not block IRE1α autophosphorylation. It reduces IL-4 production in CD4+ T cells isolated from murine spleen and LPS-stimulated increases in TNF-α and IL-6 mRNA expression and protein secretion in isolated alveolar macrophages from patients with cystic fibrosis.{39182,39183}
Brand:CaymanSKU:22110 -Out of stock