Cayman
Showing 6151–6300 of 45550 results
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4-Methylumbelliferyl-β-D-Glucopyranoside (4-MUG) is a fluorogenic substrate of β-glucosidase and β-glucocerebrosidase (also known as glucosylceramidase). In addition to its use in characterizing novel β-glucosidases, 4-MUG is used in assays to evaluate deficiency in β- glucocerebrosidase activity related to Gaucher disease.{32719,32720,32721} Hydrolysis of 4-MUG releases the fluorescent product 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251}
Brand:CaymanSKU:20948 -Out of stock
4-Methylumbelliferyl-β-D-Glucopyranoside (4-MUG) is a fluorogenic substrate of β-glucosidase and β-glucocerebrosidase (also known as glucosylceramidase). In addition to its use in characterizing novel β-glucosidases, 4-MUG is used in assays to evaluate deficiency in β- glucocerebrosidase activity related to Gaucher disease.{32719,32720,32721} Hydrolysis of 4-MUG releases the fluorescent product 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251}
Brand:CaymanSKU:20948 -Out of stock
4-Methylumbelliferyl-β-D-Glucopyranoside (4-MUG) is a fluorogenic substrate of β-glucosidase and β-glucocerebrosidase (also known as glucosylceramidase). In addition to its use in characterizing novel β-glucosidases, 4-MUG is used in assays to evaluate deficiency in β- glucocerebrosidase activity related to Gaucher disease.{32719,32720,32721} Hydrolysis of 4-MUG releases the fluorescent product 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251}
Brand:CaymanSKU:20948 -Out of stock
4-Methylumbelliferyl-β-D-Glucopyranoside (4-MUG) is a fluorogenic substrate of β-glucosidase and β-glucocerebrosidase (also known as glucosylceramidase). In addition to its use in characterizing novel β-glucosidases, 4-MUG is used in assays to evaluate deficiency in β- glucocerebrosidase activity related to Gaucher disease.{32719,32720,32721} Hydrolysis of 4-MUG releases the fluorescent product 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251}
Brand:CaymanSKU:20948 -Out of stock
4-Methylumbelliferyl-β-D-N,N’,N”-triacetylchitotrioside is a fluorogenic substrate for chitinases and chitotriosidases.{31643,31644,31645} 4-Methylumbelliferyl-β-D-N,N’,N”-triacetylchitotrioside is cleaved by chitinases and chitotriosidases to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251} It has been used to screen plasma samples for reduced chitotriosidase activity that may be indicative of lysosomal storage disorders.{31643}
Brand:CaymanSKU:19715 -Available on backorder
4-Methylumbelliferyl-β-D-N,N’,N”-triacetylchitotrioside is a fluorogenic substrate for chitinases and chitotriosidases.{31643,31644,31645} 4-Methylumbelliferyl-β-D-N,N’,N”-triacetylchitotrioside is cleaved by chitinases and chitotriosidases to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251} It has been used to screen plasma samples for reduced chitotriosidase activity that may be indicative of lysosomal storage disorders.{31643}
Brand:CaymanSKU:19715 -Available on backorder
4-Methylumbelliferyl-β-D-N,N’,N”-triacetylchitotrioside is a fluorogenic substrate for chitinases and chitotriosidases.{31643,31644,31645} 4-Methylumbelliferyl-β-D-N,N’,N”-triacetylchitotrioside is cleaved by chitinases and chitotriosidases to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases.{27251} It has been used to screen plasma samples for reduced chitotriosidase activity that may be indicative of lysosomal storage disorders.{31643}
Brand:CaymanSKU:19715 -Available on backorder
4-MTA is a methylthio analog of para-methoxyamphetamine (PMA), a hallucinogenic drug that has been scheduled in many countries.{19874} In animal models, the effects of 4-MTA are qualitatively and quantitatively indistinguishable from those of PMA.{19874} The metabolism of this compound has recently been described.{19874} This product is intended for forensic applications.
Brand:CaymanSKU:11555 - 1 mgAvailable on backorder
4-MTA is a methylthio analog of para-methoxyamphetamine (PMA), a hallucinogenic drug that has been scheduled in many countries.{19874} In animal models, the effects of 4-MTA are qualitatively and quantitatively indistinguishable from those of PMA.{19874} The metabolism of this compound has recently been described.{19874} This product is intended for forensic applications.
Brand:CaymanSKU:11555 - 10 mgAvailable on backorder
4-MTA is a methylthio analog of para-methoxyamphetamine (PMA), a hallucinogenic drug that has been scheduled in many countries.{19874} In animal models, the effects of 4-MTA are qualitatively and quantitatively indistinguishable from those of PMA.{19874} The metabolism of this compound has recently been described.{19874} This product is intended for forensic applications.
Brand:CaymanSKU:11555 - 5 mgAvailable on backorder
4-MTA, is a selective serotonergic agent which increases serotonin release, blocks its re-uptake (IC50 = 102 nM), and inhibits monoamine oxidase A.{21516,21515,19874} The detection of this designer drug in serum and urine has been described, as has its metabolism. {21281,21517,21514,19874} This product is intended for research and forensic applications.
Brand:CaymanSKU:11862 - 1 mgAvailable on backorder
4-MTA, is a selective serotonergic agent which increases serotonin release, blocks its re-uptake (IC50 = 102 nM), and inhibits monoamine oxidase A.{21516,21515,19874} The detection of this designer drug in serum and urine has been described, as has its metabolism. {21281,21517,21514,19874} This product is intended for research and forensic applications.
Brand:CaymanSKU:11862 - 10 mgAvailable on backorder
4-MTA, is a selective serotonergic agent which increases serotonin release, blocks its re-uptake (IC50 = 102 nM), and inhibits monoamine oxidase A.{21516,21515,19874} The detection of this designer drug in serum and urine has been described, as has its metabolism. {21281,21517,21514,19874} This product is intended for research and forensic applications.
Brand:CaymanSKU:11862 - 5 mgAvailable on backorder
4-Nitrobenzeneboronic acid is an arylboronic acid building block that has been used in the synthesis of phenols.{46916,46917}
Brand:CaymanSKU:30401 - 1 gAvailable on backorder
4-Nitrobenzeneboronic acid is an arylboronic acid building block that has been used in the synthesis of phenols.{46916,46917}
Brand:CaymanSKU:30401 - 5 gAvailable on backorder
4-Nitrophenyl butyrate (4-NPB) is a colorimetric substrate for lipases.{43279,43278} Upon hydrolysis, 4-NPB is converted into p-nitrophenoxide, which can be monitored using UV-Vis spectrophotometry at 400 nm to quantify lipase activity.
Brand:CaymanSKU:25439 - 1 gAvailable on backorder
4-Nitrophenyl butyrate (4-NPB) is a colorimetric substrate for lipases.{43279,43278} Upon hydrolysis, 4-NPB is converted into p-nitrophenoxide, which can be monitored using UV-Vis spectrophotometry at 400 nm to quantify lipase activity.
Brand:CaymanSKU:25439 - 10 gAvailable on backorder
4-Nitrophenyl butyrate (4-NPB) is a colorimetric substrate for lipases.{43279,43278} Upon hydrolysis, 4-NPB is converted into p-nitrophenoxide, which can be monitored using UV-Vis spectrophotometry at 400 nm to quantify lipase activity.
Brand:CaymanSKU:25439 - 25 gAvailable on backorder
4-Nitrophenyl butyrate (4-NPB) is a colorimetric substrate for lipases.{43279,43278} Upon hydrolysis, 4-NPB is converted into p-nitrophenoxide, which can be monitored using UV-Vis spectrophotometry at 400 nm to quantify lipase activity.
Brand:CaymanSKU:25439 - 5 gAvailable on backorder
4-Nitrophenyl palmitate is a colorimetric lipase and esterase substrate.{59582} Upon enzymatic hydrolysis of 4-nitrophenyl palmitate, 4-nitrophenol is released which can be quantified by colorimetric detection at 410 nm as a measure of enzyme activity. 4-Nitrophenyl palmitate has been used to characterize the activity of various bacterial and mammalian enzymes, including Burkholderia and porcine pancreatic lipases.
Brand:CaymanSKU:30870 - 1 gAvailable on backorder
4-Nitrophenyl palmitate is a colorimetric lipase and esterase substrate.{59582} Upon enzymatic hydrolysis of 4-nitrophenyl palmitate, 4-nitrophenol is released which can be quantified by colorimetric detection at 410 nm as a measure of enzyme activity. 4-Nitrophenyl palmitate has been used to characterize the activity of various bacterial and mammalian enzymes, including Burkholderia and porcine pancreatic lipases.
Brand:CaymanSKU:30870 - 10 gAvailable on backorder
4-Nitrophenyl palmitate is a colorimetric lipase and esterase substrate.{59582} Upon enzymatic hydrolysis of 4-nitrophenyl palmitate, 4-nitrophenol is released which can be quantified by colorimetric detection at 410 nm as a measure of enzyme activity. 4-Nitrophenyl palmitate has been used to characterize the activity of various bacterial and mammalian enzymes, including Burkholderia and porcine pancreatic lipases.
Brand:CaymanSKU:30870 - 25 gAvailable on backorder
4-Nitrophenyl palmitate is a colorimetric lipase and esterase substrate.{59582} Upon enzymatic hydrolysis of 4-nitrophenyl palmitate, 4-nitrophenol is released which can be quantified by colorimetric detection at 410 nm as a measure of enzyme activity. 4-Nitrophenyl palmitate has been used to characterize the activity of various bacterial and mammalian enzymes, including Burkholderia and porcine pancreatic lipases.
Brand:CaymanSKU:30870 - 5 gAvailable on backorder
4-Nitrophenyl phenylphosphonate is a substrate for 5’-nucleotide phosphodiesterases.{31514} It is a more preferable substrate to 5’-nucleotide phosphodiesterases than naturally occurring nucleotides or bis(4-nitrophenyl) phosphate because of its stability, ease of synthesis, and higher rate of hydrolysis under saturating conditions.{31513}
Brand:CaymanSKU:-Available on backorder
4-Nitrophenyl phenylphosphonate is a substrate for 5’-nucleotide phosphodiesterases.{31514} It is a more preferable substrate to 5’-nucleotide phosphodiesterases than naturally occurring nucleotides or bis(4-nitrophenyl) phosphate because of its stability, ease of synthesis, and higher rate of hydrolysis under saturating conditions.{31513}
Brand:CaymanSKU:-Available on backorder
4-Nitrophenyl α-L-rhamnopyranoside is a colorimetric substrate for naringinase.{52136} Upon hydrolysis by the α-rhamnosidase subunit of naringinase, 4-nitrophenol is released which can be quantified by colorimetric detection at 405 nm as a measure of naringinase α-rhamnosidase activity. 4-Nitrophenyl α-L-rhamnopyranoside has been used in the detection of naringinase α-rhamnosidase activity in various bacteria.
Brand:CaymanSKU:29195 - 10 mgAvailable on backorder
4-Nitrophenyl α-L-rhamnopyranoside is a colorimetric substrate for naringinase.{52136} Upon hydrolysis by the α-rhamnosidase subunit of naringinase, 4-nitrophenol is released which can be quantified by colorimetric detection at 405 nm as a measure of naringinase α-rhamnosidase activity. 4-Nitrophenyl α-L-rhamnopyranoside has been used in the detection of naringinase α-rhamnosidase activity in various bacteria.
Brand:CaymanSKU:29195 - 100 mgAvailable on backorder
4-Nitrophenyl α-L-rhamnopyranoside is a colorimetric substrate for naringinase.{52136} Upon hydrolysis by the α-rhamnosidase subunit of naringinase, 4-nitrophenol is released which can be quantified by colorimetric detection at 405 nm as a measure of naringinase α-rhamnosidase activity. 4-Nitrophenyl α-L-rhamnopyranoside has been used in the detection of naringinase α-rhamnosidase activity in various bacteria.
Brand:CaymanSKU:29195 - 25 mgAvailable on backorder
4-Nitrophenyl α-L-rhamnopyranoside is a colorimetric substrate for naringinase.{52136} Upon hydrolysis by the α-rhamnosidase subunit of naringinase, 4-nitrophenol is released which can be quantified by colorimetric detection at 405 nm as a measure of naringinase α-rhamnosidase activity. 4-Nitrophenyl α-L-rhamnopyranoside has been used in the detection of naringinase α-rhamnosidase activity in various bacteria.
Brand:CaymanSKU:29195 - 50 mgAvailable on backorder
4-Nitrophenyl β-D-cellobioside is a disaccharide and an enzyme substrate.{38351} It has been used to characterize the function of endoglucanase 1 from T. harzianum, β-glucosidase from T. xylanolyticum, and glycoside hydrolase family 3 (GH3) aryl β-glucosidases from A. oryzae.{38351,38352,38353}
Brand:CaymanSKU:23378 - 100 mgAvailable on backorder
4-Nitrophenyl β-D-cellobioside is a disaccharide and an enzyme substrate.{38351} It has been used to characterize the function of endoglucanase 1 from T. harzianum, β-glucosidase from T. xylanolyticum, and glycoside hydrolase family 3 (GH3) aryl β-glucosidases from A. oryzae.{38351,38352,38353}
Brand:CaymanSKU:23378 - 25 mgAvailable on backorder
4-Nitrophenyl β-D-cellobioside is a disaccharide and an enzyme substrate.{38351} It has been used to characterize the function of endoglucanase 1 from T. harzianum, β-glucosidase from T. xylanolyticum, and glycoside hydrolase family 3 (GH3) aryl β-glucosidases from A. oryzae.{38351,38352,38353}
Brand:CaymanSKU:23378 - 50 mgAvailable on backorder
4-Nitrophenyl β-D-cellobioside is a disaccharide and an enzyme substrate.{38351} It has been used to characterize the function of endoglucanase 1 from T. harzianum, β-glucosidase from T. xylanolyticum, and glycoside hydrolase family 3 (GH3) aryl β-glucosidases from A. oryzae.{38351,38352,38353}
Brand:CaymanSKU:23378 - 500 mgAvailable on backorder
4-Nitrophenyl β-D-cellotetraoside is small molecule cellulose mimic that consists of a tetramer of D-glucose units joined by β-1-4-glycosidic bonds. An aglycosidic bond links a 4-nitrophenyl moiety to the anomeric carbon of the first glucose unit. 4-Nitrophenyl β-D-cellotetraoside is employed in cellulose degradation studies to determine the specificity of cellulases.{34543,34544,34542} The defined, small, and soluble structure of 4-nitrophenyl β-D-cellotetraoside makes it well suited for these studies. Its fragmentation pattern after enzymatic digestion can be analyzed by TLC or by release of 4-nitrophenol which exhibits strong absorbance at 395 nm in alkaline solution.{34543,34544,34542}
Brand:CaymanSKU:21406 -Out of stock
4-Nitrophenyl β-D-cellotetraoside is small molecule cellulose mimic that consists of a tetramer of D-glucose units joined by β-1-4-glycosidic bonds. An aglycosidic bond links a 4-nitrophenyl moiety to the anomeric carbon of the first glucose unit. 4-Nitrophenyl β-D-cellotetraoside is employed in cellulose degradation studies to determine the specificity of cellulases.{34543,34544,34542} The defined, small, and soluble structure of 4-nitrophenyl β-D-cellotetraoside makes it well suited for these studies. Its fragmentation pattern after enzymatic digestion can be analyzed by TLC or by release of 4-nitrophenol which exhibits strong absorbance at 395 nm in alkaline solution.{34543,34544,34542}
Brand:CaymanSKU:21406 -Out of stock
4-Nitrophenyl β-D-cellotrioside is a chromogenic substrate for endoglucanases and cellobiohydrolases.{31609} Hydrolysis of this substrate by these enzymes liberates 4-nitrophenol, which generates a yellow color that is measured by monitoring absorbance at 405 nm.
Brand:CaymanSKU:-Available on backorder
4-Nitrophenyl β-D-cellotrioside is a chromogenic substrate for endoglucanases and cellobiohydrolases.{31609} Hydrolysis of this substrate by these enzymes liberates 4-nitrophenol, which generates a yellow color that is measured by monitoring absorbance at 405 nm.
Brand:CaymanSKU:-Available on backorder
4-Nitrophenyl β-D-cellotrioside is a chromogenic substrate for endoglucanases and cellobiohydrolases.{31609} Hydrolysis of this substrate by these enzymes liberates 4-nitrophenol, which generates a yellow color that is measured by monitoring absorbance at 405 nm.
Brand:CaymanSKU:-Available on backorder
N-acetyl-D-galactosaminidase catalyzes the cleavage of N-acetylglucosamine (GlcNAc), the monomeric unit of the polymer chitin. 4-Nitrophenyl-N-acetyl-α-D-galactosaminide can be used as a chromogenic substrate for N-acetyl-D-galactosaminidase, generating a yellow solution upon cleavage.{27296,27297,27298}
Brand:CaymanSKU:-Out of stock
N-acetyl-D-galactosaminidase catalyzes the cleavage of N-acetylglucosamine (GlcNAc), the monomeric unit of the polymer chitin. 4-Nitrophenyl-N-acetyl-α-D-galactosaminide can be used as a chromogenic substrate for N-acetyl-D-galactosaminidase, generating a yellow solution upon cleavage.{27296,27297,27298}
Brand:CaymanSKU:-Out of stock
N-acetyl-D-galactosaminidase catalyzes the cleavage of N-acetylglucosamine (GlcNAc), the monomeric unit of the polymer chitin. 4-Nitrophenyl-N-acetyl-α-D-galactosaminide can be used as a chromogenic substrate for N-acetyl-D-galactosaminidase, generating a yellow solution upon cleavage.{27296,27297,27298}
Brand:CaymanSKU:-Out of stock
N-acetyl-D-galactosaminidase catalyzes the cleavage of N-acetylglucosamine (GlcNAc), the monomeric unit of the polymer chitin. 4-Nitrophenyl-N-acetyl-α-D-galactosaminide can be used as a chromogenic substrate for N-acetyl-D-galactosaminidase, generating a yellow solution upon cleavage.{27296,27297,27298}
Brand:CaymanSKU:-Out of stock
4-Nitrophenyl-N-acetyl-β-D-glucosaminide is a chromogenic substrate for N-acetyl-β-glucosaminidase.{48651,48652} Hydrolysis of 4-nitrophenyl-N-acetyl-β-D-glucosaminide by N-acetyl-β-glucosaminidase releases 4-nitrophenol, which can be quantified by colorimetric detection at 405 nm as a measure of N-acetyl-β-glucosaminidase activity. It has been used to quantify the activity of N-acetyl-β-D-glucosaminidase in human serum and urine in parenterally fed patients.{48653}
Brand:CaymanSKU:28954 - 1 gAvailable on backorder
4-Nitrophenyl-N-acetyl-β-D-glucosaminide is a chromogenic substrate for N-acetyl-β-glucosaminidase.{48651,48652} Hydrolysis of 4-nitrophenyl-N-acetyl-β-D-glucosaminide by N-acetyl-β-glucosaminidase releases 4-nitrophenol, which can be quantified by colorimetric detection at 405 nm as a measure of N-acetyl-β-glucosaminidase activity. It has been used to quantify the activity of N-acetyl-β-D-glucosaminidase in human serum and urine in parenterally fed patients.{48653}
Brand:CaymanSKU:28954 - 100 mgAvailable on backorder
4-Nitrophenyl-N-acetyl-β-D-glucosaminide is a chromogenic substrate for N-acetyl-β-glucosaminidase.{48651,48652} Hydrolysis of 4-nitrophenyl-N-acetyl-β-D-glucosaminide by N-acetyl-β-glucosaminidase releases 4-nitrophenol, which can be quantified by colorimetric detection at 405 nm as a measure of N-acetyl-β-glucosaminidase activity. It has been used to quantify the activity of N-acetyl-β-D-glucosaminidase in human serum and urine in parenterally fed patients.{48653}
Brand:CaymanSKU:28954 - 250 mgAvailable on backorder
4-Nitrophenyl-N-acetyl-β-D-glucosaminide is a chromogenic substrate for N-acetyl-β-glucosaminidase.{48651,48652} Hydrolysis of 4-nitrophenyl-N-acetyl-β-D-glucosaminide by N-acetyl-β-glucosaminidase releases 4-nitrophenol, which can be quantified by colorimetric detection at 405 nm as a measure of N-acetyl-β-glucosaminidase activity. It has been used to quantify the activity of N-acetyl-β-D-glucosaminidase in human serum and urine in parenterally fed patients.{48653}
Brand:CaymanSKU:28954 - 500 mgAvailable on backorder
4-octyl Itaconate is a prodrug form of itaconate, an endogenous cellular metabolite produced via decarboxylation of cis-aconitate by the enzyme encoded by IRG1.{42667,40962} It is hydrolyzed to itaconate by esterases in C2C12 cells and LPS-activated mouse macrophages where it acts as a regulator of macrophage function with anti-inflammatory properties.{40962} 4-octyl Itaconate increases nuclear factor erythroid 2-related factor 2 (Nrf2) protein levels and expression of Nrf2 target genes and enhances LPS-induced Nrf2 stabilization in mouse macrophages. In vivo, 4-octyl itaconate (50 mg/kg) decreases serum levels of IL-1β and TNF-α, increases Nrf2 protein expression, and protects against LPS-induced lethality in wild-type, but not Nrf2 knockout, mice.
Brand:CaymanSKU:25374 - 100 mgAvailable on backorder
4-octyl Itaconate is a prodrug form of itaconate, an endogenous cellular metabolite produced via decarboxylation of cis-aconitate by the enzyme encoded by IRG1.{42667,40962} It is hydrolyzed to itaconate by esterases in C2C12 cells and LPS-activated mouse macrophages where it acts as a regulator of macrophage function with anti-inflammatory properties.{40962} 4-octyl Itaconate increases nuclear factor erythroid 2-related factor 2 (Nrf2) protein levels and expression of Nrf2 target genes and enhances LPS-induced Nrf2 stabilization in mouse macrophages. In vivo, 4-octyl itaconate (50 mg/kg) decreases serum levels of IL-1β and TNF-α, increases Nrf2 protein expression, and protects against LPS-induced lethality in wild-type, but not Nrf2 knockout, mice.
Brand:CaymanSKU:25374 - 25 mgAvailable on backorder
4-octyl Itaconate is a prodrug form of itaconate, an endogenous cellular metabolite produced via decarboxylation of cis-aconitate by the enzyme encoded by IRG1.{42667,40962} It is hydrolyzed to itaconate by esterases in C2C12 cells and LPS-activated mouse macrophages where it acts as a regulator of macrophage function with anti-inflammatory properties.{40962} 4-octyl Itaconate increases nuclear factor erythroid 2-related factor 2 (Nrf2) protein levels and expression of Nrf2 target genes and enhances LPS-induced Nrf2 stabilization in mouse macrophages. In vivo, 4-octyl itaconate (50 mg/kg) decreases serum levels of IL-1β and TNF-α, increases Nrf2 protein expression, and protects against LPS-induced lethality in wild-type, but not Nrf2 knockout, mice.
Brand:CaymanSKU:25374 - 250 mgAvailable on backorder
4-octyl Itaconate is a prodrug form of itaconate, an endogenous cellular metabolite produced via decarboxylation of cis-aconitate by the enzyme encoded by IRG1.{42667,40962} It is hydrolyzed to itaconate by esterases in C2C12 cells and LPS-activated mouse macrophages where it acts as a regulator of macrophage function with anti-inflammatory properties.{40962} 4-octyl Itaconate increases nuclear factor erythroid 2-related factor 2 (Nrf2) protein levels and expression of Nrf2 target genes and enhances LPS-induced Nrf2 stabilization in mouse macrophages. In vivo, 4-octyl itaconate (50 mg/kg) decreases serum levels of IL-1β and TNF-α, increases Nrf2 protein expression, and protects against LPS-induced lethality in wild-type, but not Nrf2 knockout, mice.
Brand:CaymanSKU:25374 - 50 mgAvailable on backorder
4-octynyl Itaconate is an alkyne derivative of the itaconate prodrug 4-octyl itaconate (Item No. 25374). 4-octynyl Itaconate can be used for click chemistry applications.
Brand:CaymanSKU:28455 - 1 mgAvailable on backorder
4-octynyl Itaconate is an alkyne derivative of the itaconate prodrug 4-octyl itaconate (Item No. 25374). 4-octynyl Itaconate can be used for click chemistry applications.
Brand:CaymanSKU:28455 - 10 mgAvailable on backorder
4-octynyl Itaconate is an alkyne derivative of the itaconate prodrug 4-octyl itaconate (Item No. 25374). 4-octynyl Itaconate can be used for click chemistry applications.
Brand:CaymanSKU:28455 - 5 mgAvailable on backorder
4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA (Item No. 90310) with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 µM, however it increased proliferation of MCF-7 cells.{34687} 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 µM.{16872}
Brand:CaymanSKU:21373 -Out of stock
4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA (Item No. 90310) with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 µM, however it increased proliferation of MCF-7 cells.{34687} 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 µM.{16872}
Brand:CaymanSKU:21373 -Out of stock
4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA (Item No. 90310) with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 µM, however it increased proliferation of MCF-7 cells.{34687} 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 µM.{16872}
Brand:CaymanSKU:21373 -Out of stock
4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA (Item No. 90310) with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 µM, however it increased proliferation of MCF-7 cells.{34687} 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 µM.{16872}
Brand:CaymanSKU:21373 -Out of stock
4-oxo Withaferin A is a derivative of the steroidal lactone withaferin A (Item No. 11352) that has anticancer activity.{50042} It is cytotoxic to A2780 ovarian cancer cells and carboplatin-resistant A2780 (A2780/CP70) cells (IC50s = 7.3 and <1 µM, respectively) and is 4.4-fold selective for A2780 cells over non-cancerous ARPE19 cells.
Brand:CaymanSKU:28295 - 1 mgAvailable on backorder
4-oxo Withaferin A is a derivative of the steroidal lactone withaferin A (Item No. 11352) that has anticancer activity.{50042} It is cytotoxic to A2780 ovarian cancer cells and carboplatin-resistant A2780 (A2780/CP70) cells (IC50s = 7.3 and <1 µM, respectively) and is 4.4-fold selective for A2780 cells over non-cancerous ARPE19 cells.
Brand:CaymanSKU:28295 - 10 mgAvailable on backorder
4-oxo Withaferin A is a derivative of the steroidal lactone withaferin A (Item No. 11352) that has anticancer activity.{50042} It is cytotoxic to A2780 ovarian cancer cells and carboplatin-resistant A2780 (A2780/CP70) cells (IC50s = 7.3 and <1 µM, respectively) and is 4.4-fold selective for A2780 cells over non-cancerous ARPE19 cells.
Brand:CaymanSKU:28295 - 5 mgAvailable on backorder
4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid.{869,1103} It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.{869,1103,1109} 4-oxo-2-Nonenal is a more recently identified product of lipid peroxidation.{9278,11422,11421} It actively modifies histidine and lysine residues on proteins and causes protein cross-linking.{11420,11419} 4-oxo-2-Nonenal also modifies 2′-deoxyguanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.{9278}
Brand:CaymanSKU:10185 - 1 mgAvailable on backorder
4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid.{869,1103} It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.{869,1103,1109} 4-oxo-2-Nonenal is a more recently identified product of lipid peroxidation.{9278,11422,11421} It actively modifies histidine and lysine residues on proteins and causes protein cross-linking.{11420,11419} 4-oxo-2-Nonenal also modifies 2′-deoxyguanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.{9278}
Brand:CaymanSKU:10185 - 10 mgAvailable on backorder
4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid.{869,1103} It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.{869,1103,1109} 4-oxo-2-Nonenal is a more recently identified product of lipid peroxidation.{9278,11422,11421} It actively modifies histidine and lysine residues on proteins and causes protein cross-linking.{11420,11419} 4-oxo-2-Nonenal also modifies 2′-deoxyguanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.{9278}
Brand:CaymanSKU:10185 - 5 mgAvailable on backorder
4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid.{869,1103} It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.{869,1103,1109} 4-oxo-2-Nonenal is a more recently identified product of lipid peroxidation.{9278,11422,11421} It actively modifies histidine and lysine residues on proteins and causes protein cross-linking.{11420,11419} 4-oxo-2-Nonenal also modifies 2′-deoxyguanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.{9278}
Brand:CaymanSKU:10185 - 500 µgAvailable on backorder
4-oxo-2-Nonenal (4-ONE, Item No. 10185) is a product of lipid peroxidation that actively modifies histidine and lysine residues on proteins and causes protein cross-linking.{9278,11422,11421,11420,11419} It also modifies 2′-deoxyguanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.{9278} 4-ONE alkyne is an alkyne-tagged electrophile that can be used as a probe to isolate and identify the reaction products of lipid peroxidation using click chemistry.{26588,26526}
Brand:CaymanSKU:-Out of stock
4-oxo-2-Nonenal (4-ONE, Item No. 10185) is a product of lipid peroxidation that actively modifies histidine and lysine residues on proteins and causes protein cross-linking.{9278,11422,11421,11420,11419} It also modifies 2′-deoxyguanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.{9278} 4-ONE alkyne is an alkyne-tagged electrophile that can be used as a probe to isolate and identify the reaction products of lipid peroxidation using click chemistry.{26588,26526}
Brand:CaymanSKU:-Out of stock
4-oxo-2-Nonenal (4-ONE, Item No. 10185) is a product of lipid peroxidation that actively modifies histidine and lysine residues on proteins and causes protein cross-linking.{9278,11422,11421,11420,11419} It also modifies 2′-deoxyguanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.{9278} 4-ONE alkyne is an alkyne-tagged electrophile that can be used as a probe to isolate and identify the reaction products of lipid peroxidation using click chemistry.{26588,26526}
Brand:CaymanSKU:-Out of stock
4-oxo-2-Nonenal (4-ONE, Item No. 10185) is a product of lipid peroxidation that actively modifies histidine and lysine residues on proteins and causes protein cross-linking.{9278,11422,11421,11420,11419} It also modifies 2′-deoxyguanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.{9278} 4-ONE alkyne is an alkyne-tagged electrophile that can be used as a probe to isolate and identify the reaction products of lipid peroxidation using click chemistry.{26588,26526}
Brand:CaymanSKU:-Out of stock
4-oxo-2-Nonenal-d3 (4-ONE-d3) contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-ONE (Item No. 10185) by GC- or LC-mass spectrometry (MS). 4-ONE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid.{869,1103} It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.{869,1103,1109} 4-ONE is a more recently identified product of lipid peroxidation.{9278,11422,11421} It actively modifies histidine and lysine residues on proteins and causes protein cross-linking.{11420,11419} 4-ONE also modifies 2′-deoxy guanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.{869}
Brand:CaymanSKU:10004174 - 1 mgAvailable on backorder
4-oxo-2-Nonenal-d3 (4-ONE-d3) contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-ONE (Item No. 10185) by GC- or LC-mass spectrometry (MS). 4-ONE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid.{869,1103} It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.{869,1103,1109} 4-ONE is a more recently identified product of lipid peroxidation.{9278,11422,11421} It actively modifies histidine and lysine residues on proteins and causes protein cross-linking.{11420,11419} 4-ONE also modifies 2′-deoxy guanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.{869}
Brand:CaymanSKU:10004174 - 100 µgAvailable on backorder
4-oxo-2-Nonenal-d3 (4-ONE-d3) contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-ONE (Item No. 10185) by GC- or LC-mass spectrometry (MS). 4-ONE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid.{869,1103} It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.{869,1103,1109} 4-ONE is a more recently identified product of lipid peroxidation.{9278,11422,11421} It actively modifies histidine and lysine residues on proteins and causes protein cross-linking.{11420,11419} 4-ONE also modifies 2′-deoxy guanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.{869}
Brand:CaymanSKU:10004174 - 50 µgAvailable on backorder
4-oxo-2-Nonenal-d3 (4-ONE-d3) contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-ONE (Item No. 10185) by GC- or LC-mass spectrometry (MS). 4-ONE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid.{869,1103} It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.{869,1103,1109} 4-ONE is a more recently identified product of lipid peroxidation.{9278,11422,11421} It actively modifies histidine and lysine residues on proteins and causes protein cross-linking.{11420,11419} 4-ONE also modifies 2′-deoxy guanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.{869}
Brand:CaymanSKU:10004174 - 500 µgAvailable on backorder
4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A (Item No. 11352) that has anticancer activity.{50042} It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 µM) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 µM). It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 µM). 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells.
Brand:CaymanSKU:28323 - 1 mgAvailable on backorder
4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A (Item No. 11352) that has anticancer activity.{50042} It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 µM) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 µM). It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 µM). 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells.
Brand:CaymanSKU:28323 - 10 mgAvailable on backorder
4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A (Item No. 11352) that has anticancer activity.{50042} It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 µM) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 µM). It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 µM). 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells.
Brand:CaymanSKU:28323 - 5 mgAvailable on backorder
4-P-PDOT is an antagonist of the melatonin 2 (MT2) receptor (pKi = 8.37) that displays 60-fold selectivity for MT2 over MT1.{26021,26017} 4-P-PDOT is used in cells, explants, and animals to elucidate the role of MT2 in melatonin-mediated signaling.{33899,33900}
Brand:CaymanSKU:-Available on backorder
4-P-PDOT is an antagonist of the melatonin 2 (MT2) receptor (pKi = 8.37) that displays 60-fold selectivity for MT2 over MT1.{26021,26017} 4-P-PDOT is used in cells, explants, and animals to elucidate the role of MT2 in melatonin-mediated signaling.{33899,33900}
Brand:CaymanSKU:-Available on backorder
4-P-PDOT is an antagonist of the melatonin 2 (MT2) receptor (pKi = 8.37) that displays 60-fold selectivity for MT2 over MT1.{26021,26017} 4-P-PDOT is used in cells, explants, and animals to elucidate the role of MT2 in melatonin-mediated signaling.{33899,33900}
Brand:CaymanSKU:-Available on backorder
4-P-PDOT is an antagonist of the melatonin 2 (MT2) receptor (pKi = 8.37) that displays 60-fold selectivity for MT2 over MT1.{26021,26017} 4-P-PDOT is used in cells, explants, and animals to elucidate the role of MT2 in melatonin-mediated signaling.{33899,33900}
Brand:CaymanSKU:-Available on backorder
4-palmitamido TEMPO is a lipid-soluble spin label.{49152,49153} It incorporates into vesicles and cell membranes and has been used to study the entrapment of molecules within phosphatidylcholine vesicles.{49154}
Brand:CaymanSKU:25995 - 1 mgAvailable on backorder
4-palmitamido TEMPO is a lipid-soluble spin label.{49152,49153} It incorporates into vesicles and cell membranes and has been used to study the entrapment of molecules within phosphatidylcholine vesicles.{49154}
Brand:CaymanSKU:25995 - 10 mgAvailable on backorder