Cayman
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3,4-Dimethylpyrazole (phosphate) (3,4-DMPP) is an inhibitor of nitrification deemed safe by extensive standard toxicology and ecotoxicology tests.{34653} When utilized on crops, 3,4-DMPP prevents nitrogen loss from soil, increases nitrogen use efficiency, and boosts crop yields.{34653,34654} However, a meta-analysis found no influence of 3,4-DMPP on net crop yield, although it may boost yields in alkaline soil.{34655} 3,4-DMPP may be less effective in acidic soils and in the post-harvest period.{34656,34657} DMPP interferes with ammonia monooxygenase from ammonia-oxidizing bacteria (AOB) and archaea (AOA) but may not directly affect AOB, AOA, and non-target populations.{34658}
Brand:CaymanSKU:21887 -Out of stock
3,4-Dimethylpyrazole (phosphate) (3,4-DMPP) is an inhibitor of nitrification deemed safe by extensive standard toxicology and ecotoxicology tests.{34653} When utilized on crops, 3,4-DMPP prevents nitrogen loss from soil, increases nitrogen use efficiency, and boosts crop yields.{34653,34654} However, a meta-analysis found no influence of 3,4-DMPP on net crop yield, although it may boost yields in alkaline soil.{34655} 3,4-DMPP may be less effective in acidic soils and in the post-harvest period.{34656,34657} DMPP interferes with ammonia monooxygenase from ammonia-oxidizing bacteria (AOB) and archaea (AOA) but may not directly affect AOB, AOA, and non-target populations.{34658}
Brand:CaymanSKU:21887 -Out of stock
3,4-Dimethylpyrazole (phosphate) (3,4-DMPP) is an inhibitor of nitrification deemed safe by extensive standard toxicology and ecotoxicology tests.{34653} When utilized on crops, 3,4-DMPP prevents nitrogen loss from soil, increases nitrogen use efficiency, and boosts crop yields.{34653,34654} However, a meta-analysis found no influence of 3,4-DMPP on net crop yield, although it may boost yields in alkaline soil.{34655} 3,4-DMPP may be less effective in acidic soils and in the post-harvest period.{34656,34657} DMPP interferes with ammonia monooxygenase from ammonia-oxidizing bacteria (AOB) and archaea (AOA) but may not directly affect AOB, AOA, and non-target populations.{34658}
Brand:CaymanSKU:21887 -Out of stock
3,4-Dimethylpyrazole (phosphate) (3,4-DMPP) is an inhibitor of nitrification deemed safe by extensive standard toxicology and ecotoxicology tests.{34653} When utilized on crops, 3,4-DMPP prevents nitrogen loss from soil, increases nitrogen use efficiency, and boosts crop yields.{34653,34654} However, a meta-analysis found no influence of 3,4-DMPP on net crop yield, although it may boost yields in alkaline soil.{34655} 3,4-DMPP may be less effective in acidic soils and in the post-harvest period.{34656,34657} DMPP interferes with ammonia monooxygenase from ammonia-oxidizing bacteria (AOB) and archaea (AOA) but may not directly affect AOB, AOA, and non-target populations.{34658}
Brand:CaymanSKU:21887 -Out of stock
3,4-DMA (hydrochloride) (Item No. 14142) is an analytical reference standard that is structurally categorized as an amphetamine. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:- 3,4-DMA (hydrochloride) (Item No. 14142) is an analytical reference standard that is structurally categorized as an amphetamine. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:-
3,4-Dimethoxymethamphetamine (3,4-DMMA) (hydrochloride) is an analog of 3,4-methylenedioxymethamphetamine (MDMA), a psychoactive drug and research chemical of the phenethylamine and amphetamine chemical classes. DMMA appears to interfere with monoamine transport, inhibiting uptake of noradrenalin and serotonin transporters (Kis = 22.8 and 7.7 μM, IC50s = 253.4 and 108 μM, respectively).{20483} DMMA is significantly less potent than MDMA (Kis = 0.6 and 2.5 μM; IC50s = 6.6 and 34.8 μM for MDMA inhibition of noradrenalin and serotonin transporters, respectively).{20483}
Brand:CaymanSKU:11128 - 10 mgAvailable on backorder
3,4-Dimethoxymethamphetamine (3,4-DMMA) (hydrochloride) is an analog of 3,4-methylenedioxymethamphetamine (MDMA), a psychoactive drug and research chemical of the phenethylamine and amphetamine chemical classes. DMMA appears to interfere with monoamine transport, inhibiting uptake of noradrenalin and serotonin transporters (Kis = 22.8 and 7.7 μM, IC50s = 253.4 and 108 μM, respectively).{20483} DMMA is significantly less potent than MDMA (Kis = 0.6 and 2.5 μM; IC50s = 6.6 and 34.8 μM for MDMA inhibition of noradrenalin and serotonin transporters, respectively).{20483}
Brand:CaymanSKU:11128 - 5 mgAvailable on backorder
3,4-Dimethoxymethamphetamine (3,4-DMMA) (hydrochloride) is an analog of 3,4-methylenedioxymethamphetamine (MDMA), a psychoactive drug and research chemical of the phenethylamine and amphetamine chemical classes. DMMA appears to interfere with monoamine transport, inhibiting uptake of noradrenalin and serotonin transporters (Kis = 22.8 and 7.7 μM, IC50s = 253.4 and 108 μM, respectively).{20483} DMMA is significantly less potent than MDMA (Kis = 0.6 and 2.5 μM; IC50s = 6.6 and 34.8 μM for MDMA inhibition of noradrenalin and serotonin transporters, respectively).{20483}
Brand:CaymanSKU:11128 - 50 mgAvailable on backorder
Methylone (Item No. 10986) is designer cathinone that is structurally similar to the illicit, psychotropic drug 3,4-MDMA (Item No. 13971).{20370,20369} 3,4-EDMC is an analog of methylone. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research purposes.
Brand:CaymanSKU:- Methylone (Item No. 10986) is designer cathinone that is structurally similar to the illicit, psychotropic drug 3,4-MDMA (Item No. 13971).{20370,20369} 3,4-EDMC is an analog of methylone. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research purposes.
Brand:CaymanSKU:- Methylone (Item No. 10986) is designer cathinone that is structurally similar to the illicit, psychotropic drug 3,4-MDMA (Item No. 13971).{20370,20369} 3,4-EDMC is an analog of methylone. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research purposes.
Brand:CaymanSKU:-
3,4-MDEA-d5 (hydrochloride) (exempt preparation) (Item No. 22876) is intended for use as an internal standard for the quantification of 3,4-MDEA (Item Nos. 14085 | ISO60196) by GC- or LC-MS. 3,4-MDEA is categorized as an amphetamine. It has similar psychotropic action to MDMA and shares the common name of “ecstasy”.{22187} Postmortem findings in human deaths associated with 3,4-MDEA as well as 3,4-MDMA indicate striking brain and myocardial damage as well as liver necrosis.{22188} 3,4-MDEA is regulated as a Schedule I compound in the United States. 3,4-MDEA-d5 (hydrochloride) (exempt preparation) (Item No. 22876) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
Brand:CaymanSKU:22876 - 1 mgAvailable on backorder
MDMA is a psychoactive drug, also known as ecstasy, that is banned in most countries, including the United States. 3,4-MDMA methylene homolog (hydrochloride) is a potential designer drug created by inserting a methylene group in the methylamphetamine portion of MDMA. The biological and toxicological activities of this compound have not been evaluated. This product is to be used in the forensic analysis of samples that may contain this compound.
Brand:CaymanSKU:10979 - 1 mgAvailable on backorder
MDMA is a psychoactive drug, also known as ecstasy, that is banned in most countries, including the United States. 3,4-MDMA methylene homolog (hydrochloride) is a potential designer drug created by inserting a methylene group in the methylamphetamine portion of MDMA. The biological and toxicological activities of this compound have not been evaluated. This product is to be used in the forensic analysis of samples that may contain this compound.
Brand:CaymanSKU:10979 - 10 mgAvailable on backorder
MDMA is a psychoactive drug, also known as ecstasy, that is banned in most countries, including the United States. 3,4-MDMA methylene homolog (hydrochloride) is a potential designer drug created by inserting a methylene group in the methylamphetamine portion of MDMA. The biological and toxicological activities of this compound have not been evaluated. This product is to be used in the forensic analysis of samples that may contain this compound.
Brand:CaymanSKU:10979 - 5 mgAvailable on backorder
3,4-MDMA tert-butyl Carbamate (Item No. 22740) is an analytical reference standard that is structurally characterized as an amphetamine and is a precursor in the synthesis of 3,4-MDMA (Item Nos. 13971 | ISO60190).{18959} This product is intended for research and forensic applications.
Brand:CaymanSKU:22740 -Out of stock
3,4-MDMA tert-butyl Carbamate (Item No. 22740) is an analytical reference standard that is structurally characterized as an amphetamine and is a precursor in the synthesis of 3,4-MDMA (Item Nos. 13971 | ISO60190).{18959} This product is intended for research and forensic applications.
Brand:CaymanSKU:22740 -Out of stock
3,4-MDPA (hydrochloride) is a lesser known psychoactive substituted amphetamine of the phenethylamine class. Though little is known about the pharmacological properties, metabolism, and toxicity of 3,4-MDPA, it has been used as an internal standard for qualitative and quantitative analyses of hallucinogenic designer drugs in biological samples.{21380}. This compound is intended for forensic and research purposes only.
Brand:CaymanSKU:- 3,4-MDPA (hydrochloride) is a lesser known psychoactive substituted amphetamine of the phenethylamine class. Though little is known about the pharmacological properties, metabolism, and toxicity of 3,4-MDPA, it has been used as an internal standard for qualitative and quantitative analyses of hallucinogenic designer drugs in biological samples.{21380}. This compound is intended for forensic and research purposes only.
Brand:CaymanSKU:- 3,4-MDPA (hydrochloride) is a lesser known psychoactive substituted amphetamine of the phenethylamine class. Though little is known about the pharmacological properties, metabolism, and toxicity of 3,4-MDPA, it has been used as an internal standard for qualitative and quantitative analyses of hallucinogenic designer drugs in biological samples.{21380}. This compound is intended for forensic and research purposes only.
Brand:CaymanSKU:-
3,4-Methylenedioxy PV9 (hydrochloride) (Item No. 16359) is an analytical reference standard that is structurally categorized as a cathinone. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:-Out of stock
3,4-Methylenedioxy PV9 (hydrochloride) (Item No. 16359) is an analytical reference standard that is structurally categorized as a cathinone. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:-Out of stock
3,4-Methylenedioxy PV9 (hydrochloride) (Item No. 16359) is an analytical reference standard that is structurally categorized as a cathinone. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:-Out of stock
Substituted cathinones are psychoactive compounds sold in packets labeled as bath salts or plant food.{21394,20369} 3,4-Methylenedioxy-N-benzylcathinone is a substituted cathinone that is structurally analogous to methylone, a narcotic that is regulated in the United States. This compound has a phenyl group added to the amino methyl group, substantially decreasing its solubility in aqueous solutions. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:9001330 - 10 mgAvailable on backorder
Substituted cathinones are psychoactive compounds sold in packets labeled as bath salts or plant food.{21394,20369} 3,4-Methylenedioxy-N-benzylcathinone is a substituted cathinone that is structurally analogous to methylone, a narcotic that is regulated in the United States. This compound has a phenyl group added to the amino methyl group, substantially decreasing its solubility in aqueous solutions. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:9001330 - 5 mgAvailable on backorder
Substituted cathinones are psychoactive compounds sold in packets labeled as bath salts or plant food.{21394,20369} 3,4-Methylenedioxy-N-benzylcathinone is a substituted cathinone that is structurally analogous to methylone, a narcotic that is regulated in the United States. This compound has a phenyl group added to the amino methyl group, substantially decreasing its solubility in aqueous solutions. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:9001330 - 50 mgAvailable on backorder
3,4-Methylenedioxy-α-methylaminohexanophenone (hydrochloride) (Item No. 29753) is an analytical reference standard categorized as a cathinone. This product is intended for research and forensic applications.
Brand:CaymanSKU:29753 - 1 mgAvailable on backorder
3,4-Methylenedioxy-α-methylaminohexanophenone (hydrochloride) (Item No. 29753) is an analytical reference standard categorized as a cathinone. This product is intended for research and forensic applications.
Brand:CaymanSKU:29753 - 5 mgAvailable on backorder
Pyrrolidinophenones (PPPs) are a family of compounds that feature a pyrrolidinyl group affixed to the narcotic cathinone. Many have been identified as components of designer drugs.{19508} 3,4-Methylenedioxy-α-Pyrrolidinobutiophenone (hydrochloride) shares structural features of the stimulants α-PPP (Item No. 10445) and methylenedioxypyrovalerone (Item No. 10684). This product is intended to be used for forensic applications.
Brand:CaymanSKU:10437 - 10 mgAvailable on backorder
Pyrrolidinophenones (PPPs) are a family of compounds that feature a pyrrolidinyl group affixed to the narcotic cathinone. Many have been identified as components of designer drugs.{19508} 3,4-Methylenedioxy-α-Pyrrolidinobutiophenone (hydrochloride) shares structural features of the stimulants α-PPP (Item No. 10445) and methylenedioxypyrovalerone (Item No. 10684). This product is intended to be used for forensic applications.
Brand:CaymanSKU:10437 - 5 mgAvailable on backorder
Pyrrolidinophenones (PPPs) are a family of compounds that feature a pyrrolidinyl group affixed to the narcotic cathinone. Many have been identified as components of designer drugs.{19508} 3,4-Methylenedioxy-α-Pyrrolidinobutiophenone (hydrochloride) shares structural features of the stimulants α-PPP (Item No. 10445) and methylenedioxypyrovalerone (Item No. 10684). This product is intended to be used for forensic applications.
Brand:CaymanSKU:10437 - 50 mgAvailable on backorder
3,4-Methylenedioxy Pyrovalerone (3,4-MDPV, Item No. 10684) is a central nervous system stimulant that has been widely abused.{18947} 3,4-Methylenedioxy-α-pyrrolidinohexanophenone (3,4-MDPHP) is an analog of 3,4-MDPV that differs only by the addition of a single carbon to the alkyl chain. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:-Out of stock
3,4-Methylenedioxy Pyrovalerone (3,4-MDPV, Item No. 10684) is a central nervous system stimulant that has been widely abused.{18947} 3,4-Methylenedioxy-α-pyrrolidinohexanophenone (3,4-MDPHP) is an analog of 3,4-MDPV that differs only by the addition of a single carbon to the alkyl chain. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:-Out of stock
3,4-Methylenedioxy Pyrovalerone (3,4-MDPV, Item No. 10684) is a central nervous system stimulant that has been widely abused.{18947} 3,4-Methylenedioxy-α-pyrrolidinohexanophenone (3,4-MDPHP) is an analog of 3,4-MDPV that differs only by the addition of a single carbon to the alkyl chain. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:-Out of stock
Pyrrolidinophenones (PPPs) are a family of compounds that feature a pyrrolidinyl group affixed to the narcotic cathinone. Many have been identified as components of designer drugs.{19508} 3,4-Methylenedioxy-α-Pyrrolidinopropiophenone (3,4-MD-α-PPP) (hydrochloride) shares structural features of the stimulants α-PPP (Item No. 10445) and methylenedioxypyrovalerone (Item No. 10684). The metabolism of 3,4-MD-α-PPP in male Wistar rats has been characterized.{19736,19874} This product is intended to be used for forensic applications.
Brand:CaymanSKU:10439 - 10 mgAvailable on backorder
Pyrrolidinophenones (PPPs) are a family of compounds that feature a pyrrolidinyl group affixed to the narcotic cathinone. Many have been identified as components of designer drugs.{19508} 3,4-Methylenedioxy-α-Pyrrolidinopropiophenone (3,4-MD-α-PPP) (hydrochloride) shares structural features of the stimulants α-PPP (Item No. 10445) and methylenedioxypyrovalerone (Item No. 10684). The metabolism of 3,4-MD-α-PPP in male Wistar rats has been characterized.{19736,19874} This product is intended to be used for forensic applications.
Brand:CaymanSKU:10439 - 5 mgAvailable on backorder
Pyrrolidinophenones (PPPs) are a family of compounds that feature a pyrrolidinyl group affixed to the narcotic cathinone. Many have been identified as components of designer drugs.{19508} 3,4-Methylenedioxy-α-Pyrrolidinopropiophenone (3,4-MD-α-PPP) (hydrochloride) shares structural features of the stimulants α-PPP (Item No. 10445) and methylenedioxypyrovalerone (Item No. 10684). The metabolism of 3,4-MD-α-PPP in male Wistar rats has been characterized.{19736,19874} This product is intended to be used for forensic applications.
Brand:CaymanSKU:10439 - 50 mgAvailable on backorder
3,4,5-Trimethoxyamphetamine (TMA), is a psychedelic hallucinogen that has appeared on the illicit drug market.{21281} Unlike amphetamines and cathinones, TMA has no effect on monoamine re-uptake.{19758} TMA has modest effects on the 5-HT2 serotonin receptors (pEC50s = 5.15 and 5.31 for phosphatidyl inositol release through 5-HT2A and 5-HT2C, respectively).{20772} This product is intended for research and forensic applications.
Brand:CaymanSKU:-
3,4,6-Tri-O-benzyl-β-D-mannopyranose 1,2-(methyl orthoacetate) is a synthetic intermediate used in glycosylation reactions.{26790,26789} Typically, the methyl orthoester protecting group is first removed by mild acid hydrolysis, producing a glycosyl donor. Removal of the O-benzyl protecting groups is performed late in the synthesis.
Brand:CaymanSKU:-Out of stock
3,4,6-Tri-O-benzyl-β-D-mannopyranose 1,2-(methyl orthoacetate) is a synthetic intermediate used in glycosylation reactions.{26790,26789} Typically, the methyl orthoester protecting group is first removed by mild acid hydrolysis, producing a glycosyl donor. Removal of the O-benzyl protecting groups is performed late in the synthesis.
Brand:CaymanSKU:-Out of stock
3,4,6-Tri-O-benzyl-β-D-mannopyranose 1,2-(methyl orthoacetate) is a synthetic intermediate used in glycosylation reactions.{26790,26789} Typically, the methyl orthoester protecting group is first removed by mild acid hydrolysis, producing a glycosyl donor. Removal of the O-benzyl protecting groups is performed late in the synthesis.
Brand:CaymanSKU:-Out of stock
3,4,6-Tri-O-benzyl-β-D-mannopyranose 1,2-(methyl orthoacetate) is a synthetic intermediate used in glycosylation reactions.{26790,26789} Typically, the methyl orthoester protecting group is first removed by mild acid hydrolysis, producing a glycosyl donor. Removal of the O-benzyl protecting groups is performed late in the synthesis.
Brand:CaymanSKU:-Out of stock
Resveratrol is a potent phenolic antioxidant found in natural sources that has antiproliferative activity.{9146} When the three phenolic hydroxyl groups of resveratrol are converted to methyl ethers, the inhibition of cell growth is enhanced.{10510} 3,4′,5-Trismethoxybenzophenone is an analog of trismethoxy resveratrol. It inhibits the growth of a variety of human tumor cell lines at concentrations from 0.4 to 2 µg/ml, which is 5-6 times more potent than resveratrol.{11554}
Brand:CaymanSKU:10004185 - 10 mgAvailable on backorder
Resveratrol is a potent phenolic antioxidant found in natural sources that has antiproliferative activity.{9146} When the three phenolic hydroxyl groups of resveratrol are converted to methyl ethers, the inhibition of cell growth is enhanced.{10510} 3,4′,5-Trismethoxybenzophenone is an analog of trismethoxy resveratrol. It inhibits the growth of a variety of human tumor cell lines at concentrations from 0.4 to 2 µg/ml, which is 5-6 times more potent than resveratrol.{11554}
Brand:CaymanSKU:10004185 - 100 mgAvailable on backorder
Resveratrol is a potent phenolic antioxidant found in natural sources that has antiproliferative activity.{9146} When the three phenolic hydroxyl groups of resveratrol are converted to methyl ethers, the inhibition of cell growth is enhanced.{10510} 3,4′,5-Trismethoxybenzophenone is an analog of trismethoxy resveratrol. It inhibits the growth of a variety of human tumor cell lines at concentrations from 0.4 to 2 µg/ml, which is 5-6 times more potent than resveratrol.{11554}
Brand:CaymanSKU:10004185 - 25 mgAvailable on backorder
Resveratrol is a potent phenolic antioxidant found in natural sources that has antiproliferative activity.{9146} When the three phenolic hydroxyl groups of resveratrol are converted to methyl ethers, the inhibition of cell growth is enhanced.{10510} 3,4′,5-Trismethoxybenzophenone is an analog of trismethoxy resveratrol. It inhibits the growth of a variety of human tumor cell lines at concentrations from 0.4 to 2 µg/ml, which is 5-6 times more potent than resveratrol.{11554}
Brand:CaymanSKU:10004185 - 50 mgAvailable on backorder
3,5-Dicaffeoylquinic acid (3,5-DCQA) is a natural phenolic compound that has been found in L. japonica, I. kaushue, and other plants.{36684,36685} It has antioxidant, anti-inflammatory, and antiviral biological activities.{36685,36686,36687} 3,5-DCQA scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 71.8 μM) and inhibits superoxide production in human neutrophils activated by N-formyl-Met-Leu-Phe (fMLF) and cytochalasin B (IC50 = 1.92 μM).{36685,36686} It inhibits HIV-1 integrase 3′-end processing, strand transfer, and disintegration in a cell-free assay (IC50s = 0.33, 0.34, and 0.66 μg/ml, respectively) and inhibits HIV-1-induced cytotoxicity in MT-2 cells (ED50 = 1 μg/ml).{36687} In vivo, 3,5-DCQA (25 mg/kg) protects mice from acute lung injury induced by LPS and decreases neutrophil count in bronchoalveolar lavage fluid (BALF).{36685}
Brand:CaymanSKU:24964 - 10 mgAvailable on backorder
3,5-Dicaffeoylquinic acid (3,5-DCQA) is a natural phenolic compound that has been found in L. japonica, I. kaushue, and other plants.{36684,36685} It has antioxidant, anti-inflammatory, and antiviral biological activities.{36685,36686,36687} 3,5-DCQA scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 71.8 μM) and inhibits superoxide production in human neutrophils activated by N-formyl-Met-Leu-Phe (fMLF) and cytochalasin B (IC50 = 1.92 μM).{36685,36686} It inhibits HIV-1 integrase 3′-end processing, strand transfer, and disintegration in a cell-free assay (IC50s = 0.33, 0.34, and 0.66 μg/ml, respectively) and inhibits HIV-1-induced cytotoxicity in MT-2 cells (ED50 = 1 μg/ml).{36687} In vivo, 3,5-DCQA (25 mg/kg) protects mice from acute lung injury induced by LPS and decreases neutrophil count in bronchoalveolar lavage fluid (BALF).{36685}
Brand:CaymanSKU:24964 - 25 mgAvailable on backorder
3,5-Dicaffeoylquinic acid (3,5-DCQA) is a natural phenolic compound that has been found in L. japonica, I. kaushue, and other plants.{36684,36685} It has antioxidant, anti-inflammatory, and antiviral biological activities.{36685,36686,36687} 3,5-DCQA scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 71.8 μM) and inhibits superoxide production in human neutrophils activated by N-formyl-Met-Leu-Phe (fMLF) and cytochalasin B (IC50 = 1.92 μM).{36685,36686} It inhibits HIV-1 integrase 3′-end processing, strand transfer, and disintegration in a cell-free assay (IC50s = 0.33, 0.34, and 0.66 μg/ml, respectively) and inhibits HIV-1-induced cytotoxicity in MT-2 cells (ED50 = 1 μg/ml).{36687} In vivo, 3,5-DCQA (25 mg/kg) protects mice from acute lung injury induced by LPS and decreases neutrophil count in bronchoalveolar lavage fluid (BALF).{36685}
Brand:CaymanSKU:24964 - 5 mgAvailable on backorder
3,5-Dicaffeoylquinic acid (3,5-DCQA) is a natural phenolic compound that has been found in L. japonica, I. kaushue, and other plants.{36684,36685} It has antioxidant, anti-inflammatory, and antiviral biological activities.{36685,36686,36687} 3,5-DCQA scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 71.8 μM) and inhibits superoxide production in human neutrophils activated by N-formyl-Met-Leu-Phe (fMLF) and cytochalasin B (IC50 = 1.92 μM).{36685,36686} It inhibits HIV-1 integrase 3′-end processing, strand transfer, and disintegration in a cell-free assay (IC50s = 0.33, 0.34, and 0.66 μg/ml, respectively) and inhibits HIV-1-induced cytotoxicity in MT-2 cells (ED50 = 1 μg/ml).{36687} In vivo, 3,5-DCQA (25 mg/kg) protects mice from acute lung injury induced by LPS and decreases neutrophil count in bronchoalveolar lavage fluid (BALF).{36685}
Brand:CaymanSKU:24964 - 50 mgAvailable on backorder
3,5-Dihydroxybenzaldehyde is a building block.{46911,46912} It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.
Brand:CaymanSKU:30445 - 1 gAvailable on backorder
3,5-Dihydroxybenzaldehyde is a building block.{46911,46912} It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.
Brand:CaymanSKU:30445 - 500 mgAvailable on backorder
3,5-Diiodothyroacetic acid (diac) is the acetic acid variant of thyroxine. Formulations containing dosages in the range of 100 mg/day decrease serum cholesterol and produce calorigenic effects in humans.{34677} Formulations containing diac also protect human LDL cholesterol from oxidation in vitro.{34678} Diac treatment prevents elevated liver cholesterol in rats fed a high-fat diet and reduces previously elevated liver cholesterol to control levels.{34679}
Brand:CaymanSKU:22108 -Out of stock
3,5-Diiodothyroacetic acid (diac) is the acetic acid variant of thyroxine. Formulations containing dosages in the range of 100 mg/day decrease serum cholesterol and produce calorigenic effects in humans.{34677} Formulations containing diac also protect human LDL cholesterol from oxidation in vitro.{34678} Diac treatment prevents elevated liver cholesterol in rats fed a high-fat diet and reduces previously elevated liver cholesterol to control levels.{34679}
Brand:CaymanSKU:22108 -Out of stock
3,5-Diiodothyroacetic acid (diac) is the acetic acid variant of thyroxine. Formulations containing dosages in the range of 100 mg/day decrease serum cholesterol and produce calorigenic effects in humans.{34677} Formulations containing diac also protect human LDL cholesterol from oxidation in vitro.{34678} Diac treatment prevents elevated liver cholesterol in rats fed a high-fat diet and reduces previously elevated liver cholesterol to control levels.{34679}
Brand:CaymanSKU:22108 -Out of stock
3,5-Diiodothyroacetic acid (diac) is the acetic acid variant of thyroxine. Formulations containing dosages in the range of 100 mg/day decrease serum cholesterol and produce calorigenic effects in humans.{34677} Formulations containing diac also protect human LDL cholesterol from oxidation in vitro.{34678} Diac treatment prevents elevated liver cholesterol in rats fed a high-fat diet and reduces previously elevated liver cholesterol to control levels.{34679}
Brand:CaymanSKU:22108 -Out of stock
3,5-Diiodothyropropionic acid (DITPA) is an inotropic thyroid hormone analogue of L-thyroxine (Item No. 14116) that binds to the thyroid hormone receptors TRα and TRβ (Kas = 2.4 and 4.06 x 107 M-1, respectively, for human recombinant receptors).{40907} DITPA increases mRNA expression of α-myosin heavy chain (α-MHC) in primary rat cardiomyocytes (EC50 = ~0.5 μM). Ex vivo, DITPA prevents myocardial infarction-induced loss of contractility in rabbit cardiomyocytes when administered at a dose of 3.75 mg/kg per day.{40908} DITPA (3.75 mg/kg per day) increases expression of VEGF, basic fibroblast growth factor (bFGF), angiopoietin-1, and angiopoietin-1 receptor (Tie-2) as well as angiogenesis in non-infarcted cardiac tissue in rats.{40909} It also decreases infarct size expansion, stimulates arteriolar growth, and inhibits ventricular remodeling post-myocardial infarction in rats when administered at a dose of 3.5 mg/kg per day.{40910}
Brand:CaymanSKU:23299 - 100 mgAvailable on backorder
3,5-Diiodothyropropionic acid (DITPA) is an inotropic thyroid hormone analogue of L-thyroxine (Item No. 14116) that binds to the thyroid hormone receptors TRα and TRβ (Kas = 2.4 and 4.06 x 107 M-1, respectively, for human recombinant receptors).{40907} DITPA increases mRNA expression of α-myosin heavy chain (α-MHC) in primary rat cardiomyocytes (EC50 = ~0.5 μM). Ex vivo, DITPA prevents myocardial infarction-induced loss of contractility in rabbit cardiomyocytes when administered at a dose of 3.75 mg/kg per day.{40908} DITPA (3.75 mg/kg per day) increases expression of VEGF, basic fibroblast growth factor (bFGF), angiopoietin-1, and angiopoietin-1 receptor (Tie-2) as well as angiogenesis in non-infarcted cardiac tissue in rats.{40909} It also decreases infarct size expansion, stimulates arteriolar growth, and inhibits ventricular remodeling post-myocardial infarction in rats when administered at a dose of 3.5 mg/kg per day.{40910}
Brand:CaymanSKU:23299 - 25 mgAvailable on backorder
3,5-Diiodothyropropionic acid (DITPA) is an inotropic thyroid hormone analogue of L-thyroxine (Item No. 14116) that binds to the thyroid hormone receptors TRα and TRβ (Kas = 2.4 and 4.06 x 107 M-1, respectively, for human recombinant receptors).{40907} DITPA increases mRNA expression of α-myosin heavy chain (α-MHC) in primary rat cardiomyocytes (EC50 = ~0.5 μM). Ex vivo, DITPA prevents myocardial infarction-induced loss of contractility in rabbit cardiomyocytes when administered at a dose of 3.75 mg/kg per day.{40908} DITPA (3.75 mg/kg per day) increases expression of VEGF, basic fibroblast growth factor (bFGF), angiopoietin-1, and angiopoietin-1 receptor (Tie-2) as well as angiogenesis in non-infarcted cardiac tissue in rats.{40909} It also decreases infarct size expansion, stimulates arteriolar growth, and inhibits ventricular remodeling post-myocardial infarction in rats when administered at a dose of 3.5 mg/kg per day.{40910}
Brand:CaymanSKU:23299 - 50 mgAvailable on backorder
PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer.{12235} 3,5-dimethyl PIT-1 is a dimethyl analog of PIT-1, the selective inhibitor of PIP3/Akt PH domain binding, that is designed for more favorable solubility in vivo. 3,5-dimethyl PIT-1 inhibits PI3K/Akt signaling (IC50 = 27 μM), suppressing PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 36 μM).{18957} 4T1 breast cancer growth is significantly attenuated in BALB/c mice with a dose of 1 mg/kg of 3,5-dimethyl PIT-1 per day.
Brand:CaymanSKU:10727 - 1 mgAvailable on backorder
PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer.{12235} 3,5-dimethyl PIT-1 is a dimethyl analog of PIT-1, the selective inhibitor of PIP3/Akt PH domain binding, that is designed for more favorable solubility in vivo. 3,5-dimethyl PIT-1 inhibits PI3K/Akt signaling (IC50 = 27 μM), suppressing PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 36 μM).{18957} 4T1 breast cancer growth is significantly attenuated in BALB/c mice with a dose of 1 mg/kg of 3,5-dimethyl PIT-1 per day.
Brand:CaymanSKU:10727 - 10 mgAvailable on backorder
PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer.{12235} 3,5-dimethyl PIT-1 is a dimethyl analog of PIT-1, the selective inhibitor of PIP3/Akt PH domain binding, that is designed for more favorable solubility in vivo. 3,5-dimethyl PIT-1 inhibits PI3K/Akt signaling (IC50 = 27 μM), suppressing PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 36 μM).{18957} 4T1 breast cancer growth is significantly attenuated in BALB/c mice with a dose of 1 mg/kg of 3,5-dimethyl PIT-1 per day.
Brand:CaymanSKU:10727 - 25 mgAvailable on backorder
PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer.{12235} 3,5-dimethyl PIT-1 is a dimethyl analog of PIT-1, the selective inhibitor of PIP3/Akt PH domain binding, that is designed for more favorable solubility in vivo. 3,5-dimethyl PIT-1 inhibits PI3K/Akt signaling (IC50 = 27 μM), suppressing PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 36 μM).{18957} 4T1 breast cancer growth is significantly attenuated in BALB/c mice with a dose of 1 mg/kg of 3,5-dimethyl PIT-1 per day.
Brand:CaymanSKU:10727 - 5 mgAvailable on backorder
3,5-Dinitrocatechol is a potent catechol O-methyltransferase (COMT) inhibitor (IC50 = 12 nM).{46554} It is selective for COMT over tyrosine hydroxylase, dopamine β-hydroxylase, dopamine decarboxylase, monoamine oxidase A (MAO-A), and MAO-B (IC50s = >14 μM for all). 3,5-Dintrocatechol (30 mg/kg), in combination with L-DOPA (Item No. 13248) and carbidopa (Item No. 23783), reduces 3-O-methyldopa (3-OMD) levels in rat serum, compared with control animals receiving only L-DOPA and carbidopa. Chronic administration of 3,5-dinitrocatechol (15 mg/kg per day for seven days) induces COMT-dependent thermal hyperalgesia and increases preference for dark in a light/dark preference test, indicating anxiety-like behavior, in rats, effects that can be prevented by the β-adrenergic receptor antagonist propranolol (Item No. 23349).{46555}
Brand:CaymanSKU:29180 - 1 mgAvailable on backorder
3,5-Dinitrocatechol is a potent catechol O-methyltransferase (COMT) inhibitor (IC50 = 12 nM).{46554} It is selective for COMT over tyrosine hydroxylase, dopamine β-hydroxylase, dopamine decarboxylase, monoamine oxidase A (MAO-A), and MAO-B (IC50s = >14 μM for all). 3,5-Dintrocatechol (30 mg/kg), in combination with L-DOPA (Item No. 13248) and carbidopa (Item No. 23783), reduces 3-O-methyldopa (3-OMD) levels in rat serum, compared with control animals receiving only L-DOPA and carbidopa. Chronic administration of 3,5-dinitrocatechol (15 mg/kg per day for seven days) induces COMT-dependent thermal hyperalgesia and increases preference for dark in a light/dark preference test, indicating anxiety-like behavior, in rats, effects that can be prevented by the β-adrenergic receptor antagonist propranolol (Item No. 23349).{46555}
Brand:CaymanSKU:29180 - 10 mgAvailable on backorder
3,5-Dinitrocatechol is a potent catechol O-methyltransferase (COMT) inhibitor (IC50 = 12 nM).{46554} It is selective for COMT over tyrosine hydroxylase, dopamine β-hydroxylase, dopamine decarboxylase, monoamine oxidase A (MAO-A), and MAO-B (IC50s = >14 μM for all). 3,5-Dintrocatechol (30 mg/kg), in combination with L-DOPA (Item No. 13248) and carbidopa (Item No. 23783), reduces 3-O-methyldopa (3-OMD) levels in rat serum, compared with control animals receiving only L-DOPA and carbidopa. Chronic administration of 3,5-dinitrocatechol (15 mg/kg per day for seven days) induces COMT-dependent thermal hyperalgesia and increases preference for dark in a light/dark preference test, indicating anxiety-like behavior, in rats, effects that can be prevented by the β-adrenergic receptor antagonist propranolol (Item No. 23349).{46555}
Brand:CaymanSKU:29180 - 5 mgAvailable on backorder
3,5-DMA (hydrochloride) (Item No. 19743) is an analytical reference standard that is structurally categorized as an amphetamine. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:19743 -Available on backorder
3,5-DMA (hydrochloride) (Item No. 19743) is an analytical reference standard that is structurally categorized as an amphetamine. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:19743 -Available on backorder
3,6-diacetoxy Phthalonitrile is a fluorescent probe for monitoring intracellular pH by flow cytometry in living cells.{29427} It rapidly crosses cell membranes and is cleaved by cytosolic esterases to form the fluorescent pH indicator 2,3-dicyano-hydroquinone (DCH), which is excited at UV wavelengths. DCH can be excited at 351 nm, with pH-dependent emission in the range of 450-476 nm (pH 5.0-10.0) using a potassium-based buffer.{29427}
Brand:CaymanSKU:-Available on backorder
3,6-diacetoxy Phthalonitrile is a fluorescent probe for monitoring intracellular pH by flow cytometry in living cells.{29427} It rapidly crosses cell membranes and is cleaved by cytosolic esterases to form the fluorescent pH indicator 2,3-dicyano-hydroquinone (DCH), which is excited at UV wavelengths. DCH can be excited at 351 nm, with pH-dependent emission in the range of 450-476 nm (pH 5.0-10.0) using a potassium-based buffer.{29427}
Brand:CaymanSKU:-Available on backorder
3,6-diacetoxy Phthalonitrile is a fluorescent probe for monitoring intracellular pH by flow cytometry in living cells.{29427} It rapidly crosses cell membranes and is cleaved by cytosolic esterases to form the fluorescent pH indicator 2,3-dicyano-hydroquinone (DCH), which is excited at UV wavelengths. DCH can be excited at 351 nm, with pH-dependent emission in the range of 450-476 nm (pH 5.0-10.0) using a potassium-based buffer.{29427}
Brand:CaymanSKU:-Available on backorder
3,6-dichloro-benzo[b]thiophene-2-Carboxylic acid is an inhibitor of myeloid cell leukemia 1 (Mcl-1) with a Ki value of 59 μM for binding of FITC-Mcl-1-BH2 peptide binding to Mcl-1.{36227} It has been used as a building block in the synthesis of inhibitors of Mcl-1, the toll-like receptor 3/double-stranded RNA (TLR3/dsRNA) complex, and D-amino acid oxidase (DAO).{36227,36228,36229}
Brand:CaymanSKU:22948 - 100 mgAvailable on backorder
3,6-dichloro-benzo[b]thiophene-2-Carboxylic acid is an inhibitor of myeloid cell leukemia 1 (Mcl-1) with a Ki value of 59 μM for binding of FITC-Mcl-1-BH2 peptide binding to Mcl-1.{36227} It has been used as a building block in the synthesis of inhibitors of Mcl-1, the toll-like receptor 3/double-stranded RNA (TLR3/dsRNA) complex, and D-amino acid oxidase (DAO).{36227,36228,36229}
Brand:CaymanSKU:22948 - 250 mgAvailable on backorder
3,6-dichloro-benzo[b]thiophene-2-Carboxylic acid is an inhibitor of myeloid cell leukemia 1 (Mcl-1) with a Ki value of 59 μM for binding of FITC-Mcl-1-BH2 peptide binding to Mcl-1.{36227} It has been used as a building block in the synthesis of inhibitors of Mcl-1, the toll-like receptor 3/double-stranded RNA (TLR3/dsRNA) complex, and D-amino acid oxidase (DAO).{36227,36228,36229}
Brand:CaymanSKU:22948 - 500 mgAvailable on backorder
3′-Azido-3′-deoxythymidine β-D-glucuronide is a metabolite of the nucleoside reverse transcriptase inhibitor, zidovudine (Item No. 15492), formed by direct conjugation by UDP-glucuronosyltransferase 2B7.{20875} The azido group of both zidovudine and its glucuronide metabolite can be reduced to an amino group by cytochrome P450 (CYP)3A, CYP2A6, or CYP2B1, forming 3’-amino-3’-deoxythymidine (AMT) and AMT glucuronide, respectively.{30307} Several compounds, including rifampicin (Item No. 14423), valproic acid (Item No. 13033), fluconazole (Item No. 11594), and efavirenz (Item No. 14412) are known to interfere with zidovudine glucuronidation in vitro in human liver microsomes.{30307,30306} Formation of AMT, which is 5-7-fold more toxic than the parent drug, is thought to be enhanced through inhibition of zidovudine glucuronidation.{30307}
Brand:CaymanSKU:-Available on backorder
3′-Azido-3′-deoxythymidine β-D-glucuronide is a metabolite of the nucleoside reverse transcriptase inhibitor, zidovudine (Item No. 15492), formed by direct conjugation by UDP-glucuronosyltransferase 2B7.{20875} The azido group of both zidovudine and its glucuronide metabolite can be reduced to an amino group by cytochrome P450 (CYP)3A, CYP2A6, or CYP2B1, forming 3’-amino-3’-deoxythymidine (AMT) and AMT glucuronide, respectively.{30307} Several compounds, including rifampicin (Item No. 14423), valproic acid (Item No. 13033), fluconazole (Item No. 11594), and efavirenz (Item No. 14412) are known to interfere with zidovudine glucuronidation in vitro in human liver microsomes.{30307,30306} Formation of AMT, which is 5-7-fold more toxic than the parent drug, is thought to be enhanced through inhibition of zidovudine glucuronidation.{30307}
Brand:CaymanSKU:-Available on backorder
3′-Azido-3′-deoxythymidine β-D-glucuronide is a metabolite of the nucleoside reverse transcriptase inhibitor, zidovudine (Item No. 15492), formed by direct conjugation by UDP-glucuronosyltransferase 2B7.{20875} The azido group of both zidovudine and its glucuronide metabolite can be reduced to an amino group by cytochrome P450 (CYP)3A, CYP2A6, or CYP2B1, forming 3’-amino-3’-deoxythymidine (AMT) and AMT glucuronide, respectively.{30307} Several compounds, including rifampicin (Item No. 14423), valproic acid (Item No. 13033), fluconazole (Item No. 11594), and efavirenz (Item No. 14412) are known to interfere with zidovudine glucuronidation in vitro in human liver microsomes.{30307,30306} Formation of AMT, which is 5-7-fold more toxic than the parent drug, is thought to be enhanced through inhibition of zidovudine glucuronidation.{30307}
Brand:CaymanSKU:-Available on backorder
3′-Deoxyguanosine is a ligand that can be complexed with enzymes, such as purine nucleoside phosphorylase, and receptors, in order to study structure-activity relationships.{29082,29083} This compound can also be used to selectively impair transcription.{29084}
Brand:CaymanSKU:-Available on backorder
3′-Deoxyguanosine is a ligand that can be complexed with enzymes, such as purine nucleoside phosphorylase, and receptors, in order to study structure-activity relationships.{29082,29083} This compound can also be used to selectively impair transcription.{29084}
Brand:CaymanSKU:-Available on backorder
3′-Deoxyguanosine is a ligand that can be complexed with enzymes, such as purine nucleoside phosphorylase, and receptors, in order to study structure-activity relationships.{29082,29083} This compound can also be used to selectively impair transcription.{29084}
Brand:CaymanSKU:-Available on backorder