Cayman
Showing 5101–5250 of 45550 results
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2α-Mannobiose is a disaccharide composed of two mannose molecules linked by a 1-2 glycosidic bond.{38349} It has been immobilized on monolithic capillary columns for the affinity purification of mannose binding proteins.{38350}
Brand:CaymanSKU:21848 -Out of stock
2α-Mannobiose is a disaccharide composed of two mannose molecules linked by a 1-2 glycosidic bond.{38349} It has been immobilized on monolithic capillary columns for the affinity purification of mannose binding proteins.{38350}
Brand:CaymanSKU:21848 -Out of stock
2α-Mannobiose is a disaccharide composed of two mannose molecules linked by a 1-2 glycosidic bond.{38349} It has been immobilized on monolithic capillary columns for the affinity purification of mannose binding proteins.{38350}
Brand:CaymanSKU:21848 -Out of stock
2α-Mannobiose is a disaccharide composed of two mannose molecules linked by a 1-2 glycosidic bond.{38349} It has been immobilized on monolithic capillary columns for the affinity purification of mannose binding proteins.{38350}
Brand:CaymanSKU:21848 -Out of stock
2α-methyl Androsterone (Item No. 23087) is an analytical reference standard categorized as an anabolic androgenic steroid metabolite of mesterolone (Item No. 21171) and drostanolone (Item No. 21170).{41398} This product is intended for research and forensic applications.
Brand:CaymanSKU:23087 - 1 mgAvailable on backorder
2α-methyl Androsterone (Item No. 23087) is an analytical reference standard categorized as an anabolic androgenic steroid metabolite of mesterolone (Item No. 21171) and drostanolone (Item No. 21170).{41398} This product is intended for research and forensic applications.
Brand:CaymanSKU:23087 - 5 mgAvailable on backorder
2α-methyl Androsterone (Item No. 23087) is an analytical reference standard categorized as an anabolic androgenic steroid metabolite of mesterolone (Item No. 21171) and drostanolone (Item No. 21170).{41398} This product is intended for research and forensic applications.
Brand:CaymanSKU:23087 - 500 µgAvailable on backorder
2α-methyl-5α-Androstan-17-one-3α-glucuronide (Item No. 23088) is an analytical reference standard categorized as an anabolic androgenic steroid metabolite.{48839} It is a metabolite of drostanolone (Item No. 21170). This product is intended for research and forensic applications.
Brand:CaymanSKU:23088 - 1 mgAvailable on backorder
2α-methyl-5α-Androstan-17-one-3α-glucuronide (Item No. 23088) is an analytical reference standard categorized as an anabolic androgenic steroid metabolite.{48839} It is a metabolite of drostanolone (Item No. 21170). This product is intended for research and forensic applications.
Brand:CaymanSKU:23088 - 5 mgAvailable on backorder
3-(4-Chlorophenyl)-4-hydroxybutyric acid is an inactive metabolite of the GABAB receptor agonist baclofen (Item No. 18600).{45378,45379,45380}
Brand:CaymanSKU:21483 -Out of stock
3-(4-Chlorophenyl)-4-hydroxybutyric acid is an inactive metabolite of the GABAB receptor agonist baclofen (Item No. 18600).{45378,45379,45380}
Brand:CaymanSKU:21483 -Out of stock
3-(4-Chlorophenyl)-4-hydroxybutyric acid is an inactive metabolite of the GABAB receptor agonist baclofen (Item No. 18600).{45378,45379,45380}
Brand:CaymanSKU:21483 -Out of stock
Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal.{17734,17735,17322} 3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay.{29128} It also inhibits ROCK-II and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.{29128}
Brand:CaymanSKU:-Available on backorder
Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal.{17734,17735,17322} 3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay.{29128} It also inhibits ROCK-II and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.{29128}
Brand:CaymanSKU:-Available on backorder
Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal.{17734,17735,17322} 3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay.{29128} It also inhibits ROCK-II and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.{29128}
Brand:CaymanSKU:-Available on backorder
Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal.{17734,17735,17322} 3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay.{29128} It also inhibits ROCK-II and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.{29128}
Brand:CaymanSKU:-Available on backorder
3-(N-Maleimidopropionyl)-biocytin (MPB) is a versatile thiol-specific biotinylating reagent. It is specific for sulfhydryl groups or reduced disulfide bonds and will not label proteins lacking a free sulfhydryl group at a pH between 6.5 and 7.5. This probe can be used in combination with the appropriate avidin- or streptavidin-conjugated markers (i.e., fluorescent, enzyme-conjugated, etc.). MPB can be used to detect protein sulfhydryl groups on dot blots with sensitivities in the femtomole range.{14917} MPB can be utilized for cell sorting, enzyme immunoassay, protein blotting, and various cytochemical procedures.{14917}
Brand:CaymanSKU:10008879 - 1 mgAvailable on backorder
3-(N-Maleimidopropionyl)-biocytin (MPB) is a versatile thiol-specific biotinylating reagent. It is specific for sulfhydryl groups or reduced disulfide bonds and will not label proteins lacking a free sulfhydryl group at a pH between 6.5 and 7.5. This probe can be used in combination with the appropriate avidin- or streptavidin-conjugated markers (i.e., fluorescent, enzyme-conjugated, etc.). MPB can be used to detect protein sulfhydryl groups on dot blots with sensitivities in the femtomole range.{14917} MPB can be utilized for cell sorting, enzyme immunoassay, protein blotting, and various cytochemical procedures.{14917}
Brand:CaymanSKU:10008879 - 10 mgAvailable on backorder
3-(N-Maleimidopropionyl)-biocytin (MPB) is a versatile thiol-specific biotinylating reagent. It is specific for sulfhydryl groups or reduced disulfide bonds and will not label proteins lacking a free sulfhydryl group at a pH between 6.5 and 7.5. This probe can be used in combination with the appropriate avidin- or streptavidin-conjugated markers (i.e., fluorescent, enzyme-conjugated, etc.). MPB can be used to detect protein sulfhydryl groups on dot blots with sensitivities in the femtomole range.{14917} MPB can be utilized for cell sorting, enzyme immunoassay, protein blotting, and various cytochemical procedures.{14917}
Brand:CaymanSKU:10008879 - 5 mgAvailable on backorder
3-(N-Maleimidopropionyl)-biocytin (MPB) is a versatile thiol-specific biotinylating reagent. It is specific for sulfhydryl groups or reduced disulfide bonds and will not label proteins lacking a free sulfhydryl group at a pH between 6.5 and 7.5. This probe can be used in combination with the appropriate avidin- or streptavidin-conjugated markers (i.e., fluorescent, enzyme-conjugated, etc.). MPB can be used to detect protein sulfhydryl groups on dot blots with sensitivities in the femtomole range.{14917} MPB can be utilized for cell sorting, enzyme immunoassay, protein blotting, and various cytochemical procedures.{14917}
Brand:CaymanSKU:10008879 - 50 mgAvailable on backorder
3-[2-N-(Biotinyl)aminoethyldithio]propanoic acid features a biotin group and propanoic acid separated by a disulfide linkage. The carboxyl group of propanoic acid allows biotinylation of targets through either a chemical or enzymatic acylation reaction. The disulfide bond permits removal of the biotin group with reducing agents.
Brand:CaymanSKU:-Out of stock
3-[2-N-(Biotinyl)aminoethyldithio]propanoic acid features a biotin group and propanoic acid separated by a disulfide linkage. The carboxyl group of propanoic acid allows biotinylation of targets through either a chemical or enzymatic acylation reaction. The disulfide bond permits removal of the biotin group with reducing agents.
Brand:CaymanSKU:-Out of stock
3-[2-N-(Biotinyl)aminoethyldithio]propanoic acid features a biotin group and propanoic acid separated by a disulfide linkage. The carboxyl group of propanoic acid allows biotinylation of targets through either a chemical or enzymatic acylation reaction. The disulfide bond permits removal of the biotin group with reducing agents.
Brand:CaymanSKU:-Out of stock
3-[2-N-(Biotinyl)aminoethyldithio]propanoic acid features a biotin group and propanoic acid separated by a disulfide linkage. The carboxyl group of propanoic acid allows biotinylation of targets through either a chemical or enzymatic acylation reaction. The disulfide bond permits removal of the biotin group with reducing agents.
Brand:CaymanSKU:-Out of stock
3-acetyl-11-keto-β-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata (frankincense).{30044} It selectively inhibits 5-lipoxygenase (IC50 = 1.5 µM) in an enzyme-directed, nonredox, and noncompetitive manner.{6066} 3-acetyl-11-keto-β-Boswellic acid and other members of the boswellic acid family have been studied for potential use in the control of inflammatory diseases, including arthritis and cancer.{30048,30047,30045,30046}
Brand:CaymanSKU:11672 - 1 mgAvailable on backorder
3-acetyl-11-keto-β-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata (frankincense).{30044} It selectively inhibits 5-lipoxygenase (IC50 = 1.5 µM) in an enzyme-directed, nonredox, and noncompetitive manner.{6066} 3-acetyl-11-keto-β-Boswellic acid and other members of the boswellic acid family have been studied for potential use in the control of inflammatory diseases, including arthritis and cancer.{30048,30047,30045,30046}
Brand:CaymanSKU:11672 - 10 mgAvailable on backorder
3-acetyl-11-keto-β-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata (frankincense).{30044} It selectively inhibits 5-lipoxygenase (IC50 = 1.5 µM) in an enzyme-directed, nonredox, and noncompetitive manner.{6066} 3-acetyl-11-keto-β-Boswellic acid and other members of the boswellic acid family have been studied for potential use in the control of inflammatory diseases, including arthritis and cancer.{30048,30047,30045,30046}
Brand:CaymanSKU:11672 - 5 mgAvailable on backorder
3-Acetyldeoxy nivalenol is a mycotoxin that has been found in F. graminearum.{31920} In vivo, 3-acetyldeoxy nivalenol (40 mg/kg) induces duodenal and splenic cell necrosis, as well as lethality (LD50 = 70 mg/kg) in mice.{61111}
Brand:CaymanSKU:11429 - 1 mgAvailable on backorder
3-Acetyldeoxy nivalenol is a mycotoxin that has been found in F. graminearum.{31920} In vivo, 3-acetyldeoxy nivalenol (40 mg/kg) induces duodenal and splenic cell necrosis, as well as lethality (LD50 = 70 mg/kg) in mice.{61111}
Brand:CaymanSKU:11429 - 10 mgAvailable on backorder
3-Acetyldeoxy nivalenol is a mycotoxin that has been found in F. graminearum.{31920} In vivo, 3-acetyldeoxy nivalenol (40 mg/kg) induces duodenal and splenic cell necrosis, as well as lethality (LD50 = 70 mg/kg) in mice.{61111}
Brand:CaymanSKU:11429 - 5 mgAvailable on backorder
3-Acetyldeoxy nivalenol-13C17 is intended for use as an internal standard for the quantification of 3-acetyldeoxy nivalenol (Item No. 11429) by GC- or LC-MS. 3-Acetyldeoxy nivalenol is a mycotoxin that has been found in F. graminearum.{31920} In vivo, 3-acetyldeoxy nivalenol (40 mg/kg) induces duodenal and splenic cell necrosis, as well as lethality (LD50 = 70 mg/kg) in mice.{61111}
Brand:CaymanSKU:31258 - 1.2 mlAvailable on backorder
3-Acetylmorphine (3-MAM) is a less active metabolite of heroin (Item No. 9001543) compared to the more active 6-MAM (Item Nos. 19418 | 15880) and morphine (Item No. ISO60147).{25995,25996} 3-MAM has relatively weak affinity for µ-opioid receptors due to the placement of the acetyl group in the 3 position. This product is intended only for forensic and research purposes.
Brand:CaymanSKU:9001954 - 10 mgAvailable on backorder
3-Acetylmorphine (3-MAM) is a less active metabolite of heroin (Item No. 9001543) compared to the more active 6-MAM (Item Nos. 19418 | 15880) and morphine (Item No. ISO60147).{25995,25996} 3-MAM has relatively weak affinity for µ-opioid receptors due to the placement of the acetyl group in the 3 position. This product is intended only for forensic and research purposes.
Brand:CaymanSKU:9001954 - 5 mgAvailable on backorder
3-Acetylmorphine (3-MAM) is a less active metabolite of heroin (Item No. 9001543) compared to the more active 6-MAM (Item Nos. 19418 | 15880) and morphine (Item No. ISO60147).{25995,25996} 3-MAM has relatively weak affinity for µ-opioid receptors due to the placement of the acetyl group in the 3 position. This product is intended only for forensic and research purposes.
Brand:CaymanSKU:9001954 - 50 mgAvailable on backorder
3-Acetylpyridine NAD (APAD) is an analog of NAD+ (free acid) (nicotinamide adenine dinucleotide; Item No. 16077), a signaling molecule and cofactor or substrate for many enzymes.{20368,34523} APAD has been used to study the mechanisms of oxidative phosphorylation.{34522} It can be reduced by transdehydrogenase from NADH (sodium salt) (Item No. 16078).{34525} It can be reduced more efficiently and is more stable than NAD+; thus, it is useful as a substitute.{34524}
Brand:CaymanSKU:21884 -Out of stock
3-Acetylpyridine NAD (APAD) is an analog of NAD+ (free acid) (nicotinamide adenine dinucleotide; Item No. 16077), a signaling molecule and cofactor or substrate for many enzymes.{20368,34523} APAD has been used to study the mechanisms of oxidative phosphorylation.{34522} It can be reduced by transdehydrogenase from NADH (sodium salt) (Item No. 16078).{34525} It can be reduced more efficiently and is more stable than NAD+; thus, it is useful as a substitute.{34524}
Brand:CaymanSKU:21884 -Out of stock
3-Acetylpyridine NAD (APAD) is an analog of NAD+ (free acid) (nicotinamide adenine dinucleotide; Item No. 16077), a signaling molecule and cofactor or substrate for many enzymes.{20368,34523} APAD has been used to study the mechanisms of oxidative phosphorylation.{34522} It can be reduced by transdehydrogenase from NADH (sodium salt) (Item No. 16078).{34525} It can be reduced more efficiently and is more stable than NAD+; thus, it is useful as a substitute.{34524}
Brand:CaymanSKU:21884 -Out of stock
3-Acetylpyridine NAD (APAD) is an analog of NAD+ (free acid) (nicotinamide adenine dinucleotide; Item No. 16077), a signaling molecule and cofactor or substrate for many enzymes.{20368,34523} APAD has been used to study the mechanisms of oxidative phosphorylation.{34522} It can be reduced by transdehydrogenase from NADH (sodium salt) (Item No. 16078).{34525} It can be reduced more efficiently and is more stable than NAD+; thus, it is useful as a substitute.{34524}
Brand:CaymanSKU:21884 -Out of stock
3-Acetylursolic acid is a triterpene and derivative of ursolic acid (Item No. 10072) with diverse biological activities.{46903,46904,46905} It inhibits ADP-, thrombin-, or epinephrine-induced aggregation of isolated rat platelets (IC50s = P. falciparum in vitro (IC50 = 4 µM).{46904} It is also active against B. cereus, S. aureus, and S. pneumoniae (MICs = 39.1, 19.6, and 4.81 µM, respectively).{46905} It is cytotoxic to HepG2 cells (LC50 = 351 µM).
Brand:CaymanSKU:30220 - 10 mgAvailable on backorder
3-Acetylursolic acid is a triterpene and derivative of ursolic acid (Item No. 10072) with diverse biological activities.{46903,46904,46905} It inhibits ADP-, thrombin-, or epinephrine-induced aggregation of isolated rat platelets (IC50s = P. falciparum in vitro (IC50 = 4 µM).{46904} It is also active against B. cereus, S. aureus, and S. pneumoniae (MICs = 39.1, 19.6, and 4.81 µM, respectively).{46905} It is cytotoxic to HepG2 cells (LC50 = 351 µM).
Brand:CaymanSKU:30220 - 25 mgAvailable on backorder
3-Acetylursolic acid is a triterpene and derivative of ursolic acid (Item No. 10072) with diverse biological activities.{46903,46904,46905} It inhibits ADP-, thrombin-, or epinephrine-induced aggregation of isolated rat platelets (IC50s = P. falciparum in vitro (IC50 = 4 µM).{46904} It is also active against B. cereus, S. aureus, and S. pneumoniae (MICs = 39.1, 19.6, and 4.81 µM, respectively).{46905} It is cytotoxic to HepG2 cells (LC50 = 351 µM).
Brand:CaymanSKU:30220 - 5 mgAvailable on backorder
3-Acetylursolic acid is a triterpene and derivative of ursolic acid (Item No. 10072) with diverse biological activities.{46903,46904,46905} It inhibits ADP-, thrombin-, or epinephrine-induced aggregation of isolated rat platelets (IC50s = P. falciparum in vitro (IC50 = 4 µM).{46904} It is also active against B. cereus, S. aureus, and S. pneumoniae (MICs = 39.1, 19.6, and 4.81 µM, respectively).{46905} It is cytotoxic to HepG2 cells (LC50 = 351 µM).
Brand:CaymanSKU:30220 - 50 mgAvailable on backorder
The poly(ADP-ribose) polymerases (PARPs) comprise a family of enzymes which post-translationally modify proteins by poly(ADP-ribosyl)ation. Since some PARPs are activated by DNA strand breaks, PARP signaling has roles in DNA repair, apoptosis, inflammation, and other cellular responses. 3-amino Benzamide is an inhibitor of PARPs (Ki = 1.8 μM).{20002} Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis.{19998,19999} It has PARP-mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer.{20003,20000,18991}
Brand:CaymanSKU:10397 - 1 gAvailable on backorder
The poly(ADP-ribose) polymerases (PARPs) comprise a family of enzymes which post-translationally modify proteins by poly(ADP-ribosyl)ation. Since some PARPs are activated by DNA strand breaks, PARP signaling has roles in DNA repair, apoptosis, inflammation, and other cellular responses. 3-amino Benzamide is an inhibitor of PARPs (Ki = 1.8 μM).{20002} Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis.{19998,19999} It has PARP-mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer.{20003,20000,18991}
Brand:CaymanSKU:10397 - 5 gAvailable on backorder
Brand:CaymanSKU:11074 - 1 gAvailable on backorder
Brand:CaymanSKU:11074 - 5 gAvailable on backorder
Brand:CaymanSKU:11074 - 500 mgAvailable on backorder
Brand:CaymanSKU:11064 - 1 gAvailable on backorder
Brand:CaymanSKU:11064 - 5 gAvailable on backorder
Brand:CaymanSKU:11064 - 500 mgAvailable on backorder
3-Amino-2,6-piperidinedione is an active metabolite of (±)-thalidomide (Item No. 14610).{58145} In vivo, 3-amino-2,6-piperidinedione (400 mg/kg) increases hexobarbitone-induced sleeping time in rats.
Brand:CaymanSKU:31698 - 100 mgAvailable on backorder
3-Amino-2,6-piperidinedione is an active metabolite of (±)-thalidomide (Item No. 14610).{58145} In vivo, 3-amino-2,6-piperidinedione (400 mg/kg) increases hexobarbitone-induced sleeping time in rats.
Brand:CaymanSKU:31698 - 250 mgAvailable on backorder
3-Amino-2,6-piperidinedione is an active metabolite of (±)-thalidomide (Item No. 14610).{58145} In vivo, 3-amino-2,6-piperidinedione (400 mg/kg) increases hexobarbitone-induced sleeping time in rats.
Brand:CaymanSKU:31698 - 50 mgAvailable on backorder
3-Amino-2,6-piperidinedione is an active metabolite of (±)-thalidomide (Item No. 14610).{58145} In vivo, 3-amino-2,6-piperidinedione (400 mg/kg) increases hexobarbitone-induced sleeping time in rats.
Brand:CaymanSKU:31698 - 500 mgAvailable on backorder
3-Aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay).{36477,23832} It induces relaxation in unstimulated isolated guinea pig ileum longitudinal muscle and reverses GABA- and baclofen-induced inhibition of twitch responses in isolated guinea pig ileum longitudinal muscle.{36477} 3-APPA (5 mg/kg) completely inhibits GABA- and baclofen-induced inhibition of vagally stimulated bronchospasms in guinea pigs.{36478} It also reverses the antitussive effect of baclofen in cats when administered at a dose of 3 mg/kg.{36479}
Brand:CaymanSKU:23556 - 100 mgAvailable on backorder
3-Aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay).{36477,23832} It induces relaxation in unstimulated isolated guinea pig ileum longitudinal muscle and reverses GABA- and baclofen-induced inhibition of twitch responses in isolated guinea pig ileum longitudinal muscle.{36477} 3-APPA (5 mg/kg) completely inhibits GABA- and baclofen-induced inhibition of vagally stimulated bronchospasms in guinea pigs.{36478} It also reverses the antitussive effect of baclofen in cats when administered at a dose of 3 mg/kg.{36479}
Brand:CaymanSKU:23556 - 250 mgAvailable on backorder
3-Aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay).{36477,23832} It induces relaxation in unstimulated isolated guinea pig ileum longitudinal muscle and reverses GABA- and baclofen-induced inhibition of twitch responses in isolated guinea pig ileum longitudinal muscle.{36477} 3-APPA (5 mg/kg) completely inhibits GABA- and baclofen-induced inhibition of vagally stimulated bronchospasms in guinea pigs.{36478} It also reverses the antitussive effect of baclofen in cats when administered at a dose of 3 mg/kg.{36479}
Brand:CaymanSKU:23556 - 500 mgAvailable on backorder
Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.{14245} 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity.{25052} At 5 μM it can enhance DU145, U251, and PSN1 tumor cell radiosensitivity in vitro, inhibiting DNA synthesis and repair.{25052} It destroys the tyrosine free radical in the R2/p53R2 subunits of ribonucleotide reductase by forming a redox active complex with iron, thus producing reactive oxygen species.{25051} Furthermore, 3-AP has been shown to activate an endoplasmic reticulum stress pathway, leading to the unfolded protein response and apoptosis.{25050}
Brand:CaymanSKU:- Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.{14245} 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity.{25052} At 5 μM it can enhance DU145, U251, and PSN1 tumor cell radiosensitivity in vitro, inhibiting DNA synthesis and repair.{25052} It destroys the tyrosine free radical in the R2/p53R2 subunits of ribonucleotide reductase by forming a redox active complex with iron, thus producing reactive oxygen species.{25051} Furthermore, 3-AP has been shown to activate an endoplasmic reticulum stress pathway, leading to the unfolded protein response and apoptosis.{25050}
Brand:CaymanSKU:- Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.{14245} 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity.{25052} At 5 μM it can enhance DU145, U251, and PSN1 tumor cell radiosensitivity in vitro, inhibiting DNA synthesis and repair.{25052} It destroys the tyrosine free radical in the R2/p53R2 subunits of ribonucleotide reductase by forming a redox active complex with iron, thus producing reactive oxygen species.{25051} Furthermore, 3-AP has been shown to activate an endoplasmic reticulum stress pathway, leading to the unfolded protein response and apoptosis.{25050}
Brand:CaymanSKU:- Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.{14245} 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity.{25052} At 5 μM it can enhance DU145, U251, and PSN1 tumor cell radiosensitivity in vitro, inhibiting DNA synthesis and repair.{25052} It destroys the tyrosine free radical in the R2/p53R2 subunits of ribonucleotide reductase by forming a redox active complex with iron, thus producing reactive oxygen species.{25051} Furthermore, 3-AP has been shown to activate an endoplasmic reticulum stress pathway, leading to the unfolded protein response and apoptosis.{25050}
Brand:CaymanSKU:-
3-BODIPY-propanoylaminocaproic acid N-hydroxysuccinimide ester (BODIPY FL-X SE) is an amine-reactive fluorescent probe.{38447} BODIPY FL-X SE has been used to visualize proteins immobilized on PVDF membranes with minor excitation peaks at 300-360 nm, a primary excitation peak at 504 nm, and an emission maximum at 511 nm. It has also been used to increase the hydrophobicity and detectability of amino acids in transient trapping-micellar electrokinetic chromatography.{38448}
Brand:CaymanSKU:20672 -Available on backorder
3-BODIPY-propanoylaminocaproic acid N-hydroxysuccinimide ester (BODIPY FL-X SE) is an amine-reactive fluorescent probe.{38447} BODIPY FL-X SE has been used to visualize proteins immobilized on PVDF membranes with minor excitation peaks at 300-360 nm, a primary excitation peak at 504 nm, and an emission maximum at 511 nm. It has also been used to increase the hydrophobicity and detectability of amino acids in transient trapping-micellar electrokinetic chromatography.{38448}
Brand:CaymanSKU:20672 -Available on backorder
3-BODIPY-propanoylaminocaproic acid N-hydroxysuccinimide ester (BODIPY FL-X SE) is an amine-reactive fluorescent probe.{38447} BODIPY FL-X SE has been used to visualize proteins immobilized on PVDF membranes with minor excitation peaks at 300-360 nm, a primary excitation peak at 504 nm, and an emission maximum at 511 nm. It has also been used to increase the hydrophobicity and detectability of amino acids in transient trapping-micellar electrokinetic chromatography.{38448}
Brand:CaymanSKU:20672 -Available on backorder
The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. The 1C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases, with AKR1C1 being a 20α-HSD and the other three being 3α-HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20α-hydroxy progesterone.{17634} In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function.{17637,17636,17638,17635} 3-bromo-5-phenyl Salicylic acid selectively inhibits AKR1C1 (Ki = 4 nM) over AKR1C2 (Ki = 87 nM), AKR1C3 (Ki = 4.2 μM), and AKR1C4 (Ki = 18.2 μM).{17245} Moreover, it potently inhibits the metabolism of progesterone by bovine aortic endothelial cells overexpressing AKR1C1 (IC50 = 460 nM).{17245}
Brand:CaymanSKU:- The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. The 1C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases, with AKR1C1 being a 20α-HSD and the other three being 3α-HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20α-hydroxy progesterone.{17634} In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function.{17637,17636,17638,17635} 3-bromo-5-phenyl Salicylic acid selectively inhibits AKR1C1 (Ki = 4 nM) over AKR1C2 (Ki = 87 nM), AKR1C3 (Ki = 4.2 μM), and AKR1C4 (Ki = 18.2 μM).{17245} Moreover, it potently inhibits the metabolism of progesterone by bovine aortic endothelial cells overexpressing AKR1C1 (IC50 = 460 nM).{17245}
Brand:CaymanSKU:- The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. The 1C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases, with AKR1C1 being a 20α-HSD and the other three being 3α-HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20α-hydroxy progesterone.{17634} In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function.{17637,17636,17638,17635} 3-bromo-5-phenyl Salicylic acid selectively inhibits AKR1C1 (Ki = 4 nM) over AKR1C2 (Ki = 87 nM), AKR1C3 (Ki = 4.2 μM), and AKR1C4 (Ki = 18.2 μM).{17245} Moreover, it potently inhibits the metabolism of progesterone by bovine aortic endothelial cells overexpressing AKR1C1 (IC50 = 460 nM).{17245}
Brand:CaymanSKU:- The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. The 1C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases, with AKR1C1 being a 20α-HSD and the other three being 3α-HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20α-hydroxy progesterone.{17634} In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function.{17637,17636,17638,17635} 3-bromo-5-phenyl Salicylic acid selectively inhibits AKR1C1 (Ki = 4 nM) over AKR1C2 (Ki = 87 nM), AKR1C3 (Ki = 4.2 μM), and AKR1C4 (Ki = 18.2 μM).{17245} Moreover, it potently inhibits the metabolism of progesterone by bovine aortic endothelial cells overexpressing AKR1C1 (IC50 = 460 nM).{17245}
Brand:CaymanSKU:-
3-Bromo-7-nitroindazole is a more potent inhibitor of nNOS than 7-nitroindazole in vitro, but unlike 7-nitroindazole, it is also potent against iNOS. The IC50 values for inhibition of rat nNOS, bovine eNOS, and rat iNOS are 0.17, 0.86, and 0.29 µM, respectively.{1339}
Brand:CaymanSKU:81345 - 100 mgAvailable on backorder
3-Bromo-7-nitroindazole is a more potent inhibitor of nNOS than 7-nitroindazole in vitro, but unlike 7-nitroindazole, it is also potent against iNOS. The IC50 values for inhibition of rat nNOS, bovine eNOS, and rat iNOS are 0.17, 0.86, and 0.29 µM, respectively.{1339}
Brand:CaymanSKU:81345 - 25 mgAvailable on backorder
3-Bromo-7-nitroindazole is a more potent inhibitor of nNOS than 7-nitroindazole in vitro, but unlike 7-nitroindazole, it is also potent against iNOS. The IC50 values for inhibition of rat nNOS, bovine eNOS, and rat iNOS are 0.17, 0.86, and 0.29 µM, respectively.{1339}
Brand:CaymanSKU:81345 - 250 mgAvailable on backorder
3-Bromo-7-nitroindazole is a more potent inhibitor of nNOS than 7-nitroindazole in vitro, but unlike 7-nitroindazole, it is also potent against iNOS. The IC50 values for inhibition of rat nNOS, bovine eNOS, and rat iNOS are 0.17, 0.86, and 0.29 µM, respectively.{1339}
Brand:CaymanSKU:81345 - 50 mgAvailable on backorder
4-Bromoamphetamine (4-BA) (Item No. 9001850) is a para-substituted amphetamine that acts as a monoamine releasing agent.{25537,25538} It is highly neurotoxic, producing long-term depletion of serotonin.{25537,25538} 3-BA is a structural isomer of 4-BA, having the bromine at the three rather than the four position. This product is intended only for forensic and research purposes.
Brand:CaymanSKU:9001849 - 1 mgAvailable on backorder
4-Bromoamphetamine (4-BA) (Item No. 9001850) is a para-substituted amphetamine that acts as a monoamine releasing agent.{25537,25538} It is highly neurotoxic, producing long-term depletion of serotonin.{25537,25538} 3-BA is a structural isomer of 4-BA, having the bromine at the three rather than the four position. This product is intended only for forensic and research purposes.
Brand:CaymanSKU:9001849 - 10 mgAvailable on backorder
4-Bromoamphetamine (4-BA) (Item No. 9001850) is a para-substituted amphetamine that acts as a monoamine releasing agent.{25537,25538} It is highly neurotoxic, producing long-term depletion of serotonin.{25537,25538} 3-BA is a structural isomer of 4-BA, having the bromine at the three rather than the four position. This product is intended only for forensic and research purposes.
Brand:CaymanSKU:9001849 - 5 mgAvailable on backorder
3-Bromomethcathinone is a designer drug which has been identified in products marketed as bath salts or plant food.{22047} The physiological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- 3-Bromomethcathinone is a designer drug which has been identified in products marketed as bath salts or plant food.{22047} The physiological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:- 3-Bromomethcathinone is a designer drug which has been identified in products marketed as bath salts or plant food.{22047} The physiological properties of this compound are not known. This product is intended for forensic and research applications.
Brand:CaymanSKU:-
3-Bromopyruvic Acid (3-BP) is an alkylating agent and an antimetabolite of pyruvate that is metabolized through glutathione conjugation.{34038,34035} It decreases proliferation of hepatocellular carcinoma BEL-7402 cells that express hexokinase II, an isoform of hexokinase overexpressed in many cancers.{43142,34037} 3-BP reduces tumor growth and induces tumor necrosis in a hepatocellular carcinoma mouse xenograft model when administered at a dose of 50 mg/kg per day, six days per week, for three weeks.{43142}
Brand:CaymanSKU:-Available on backorder
3-Bromopyruvic Acid (3-BP) is an alkylating agent and an antimetabolite of pyruvate that is metabolized through glutathione conjugation.{34038,34035} It decreases proliferation of hepatocellular carcinoma BEL-7402 cells that express hexokinase II, an isoform of hexokinase overexpressed in many cancers.{43142,34037} 3-BP reduces tumor growth and induces tumor necrosis in a hepatocellular carcinoma mouse xenograft model when administered at a dose of 50 mg/kg per day, six days per week, for three weeks.{43142}
Brand:CaymanSKU:-Available on backorder
3-Bromotyrosine is a product of protein oxidation found after activation of eosinophils during an allergic response.{39006,39007,39009} It has been used as a marker of eosinophil peroxidase-induced protein oxidation in vitro and in vivo.{39007,39010} In addition to its production in eosinophils, 3-bromotyrosine is found at 5-fold higher levels in peritoneal exudate from mice infected with K. pneumoniae compared with uninfected animals, suggesting neutrophils release higher levels of oxidized products during inflammation.{39011} In a human study, 3-bromotyrosine was increased 10-fold in allergen-challenged lung samples from subjects with allergen-induced asthma.{39007}
Brand:CaymanSKU:22606 -Out of stock