Cayman
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24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that is generated from the action of CYP46 on cholesterol found in the brain and plays an important role in cholesterol homeostasis.{15406} 24(R)-hydroxy Cholesterol is a synthetic enantiomer of 24(S)-hydroxy cholesterol that activates LXRα and LXRβ nuclear receptors with slightly reduced potency (EC50 = 7 and 4 μM, respectively) compared to the natural isomer (EC50 = 4 and 3 μM, respectively).{15406,25539}
Brand:CaymanSKU:10217 - 1 mgAvailable on backorder
24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that is generated from the action of CYP46 on cholesterol found in the brain and plays an important role in cholesterol homeostasis.{15406} 24(R)-hydroxy Cholesterol is a synthetic enantiomer of 24(S)-hydroxy cholesterol that activates LXRα and LXRβ nuclear receptors with slightly reduced potency (EC50 = 7 and 4 μM, respectively) compared to the natural isomer (EC50 = 4 and 3 μM, respectively).{15406,25539}
Brand:CaymanSKU:10217 - 10 mgAvailable on backorder
24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that is generated from the action of CYP46 on cholesterol found in the brain and plays an important role in cholesterol homeostasis.{15406} 24(R)-hydroxy Cholesterol is a synthetic enantiomer of 24(S)-hydroxy cholesterol that activates LXRα and LXRβ nuclear receptors with slightly reduced potency (EC50 = 7 and 4 μM, respectively) compared to the natural isomer (EC50 = 4 and 3 μM, respectively).{15406,25539}
Brand:CaymanSKU:10217 - 5 mgAvailable on backorder
24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that has important roles in cholesterol homeostasis. It is generated by the action of CYP46 on cholesterol in the brain and diffuses across the blood-brain barrier to the systemic circulation where it can modulate cell signaling, be used for further sterol biosynthesis, or be metabolized in the liver.{15406} 24(S)-hydroxy cholesterol potently activates LXRα and LXRβ nuclear receptors (EC50 = 4 and 3 μM, respectively), causing upregulation of cholesterol-lowering genes.{15406,25539,15410} In the brain, this oxysterol controls cholesterol processing to facilitate neurological repair during Alzheimer’s disease and other neuropathological conditions.{15406}
Brand:CaymanSKU:10009931 - 1 mgAvailable on backorder
24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that has important roles in cholesterol homeostasis. It is generated by the action of CYP46 on cholesterol in the brain and diffuses across the blood-brain barrier to the systemic circulation where it can modulate cell signaling, be used for further sterol biosynthesis, or be metabolized in the liver.{15406} 24(S)-hydroxy cholesterol potently activates LXRα and LXRβ nuclear receptors (EC50 = 4 and 3 μM, respectively), causing upregulation of cholesterol-lowering genes.{15406,25539,15410} In the brain, this oxysterol controls cholesterol processing to facilitate neurological repair during Alzheimer’s disease and other neuropathological conditions.{15406}
Brand:CaymanSKU:10009931 - 10 mgAvailable on backorder
24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that has important roles in cholesterol homeostasis. It is generated by the action of CYP46 on cholesterol in the brain and diffuses across the blood-brain barrier to the systemic circulation where it can modulate cell signaling, be used for further sterol biosynthesis, or be metabolized in the liver.{15406} 24(S)-hydroxy cholesterol potently activates LXRα and LXRβ nuclear receptors (EC50 = 4 and 3 μM, respectively), causing upregulation of cholesterol-lowering genes.{15406,25539,15410} In the brain, this oxysterol controls cholesterol processing to facilitate neurological repair during Alzheimer’s disease and other neuropathological conditions.{15406}
Brand:CaymanSKU:10009931 - 5 mgAvailable on backorder
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs) in the developing ventral midbrain to induce stem cell differentiation into dopaminergic neurons. 24(S),25-epoxy Cholesterol inhibits IL-6 production and degranulation of bone marrow-derived murine mast cells that express LXRβ.{43945} It inhibits the conversion of desmosterol to cholesterol by 3β-hydroxysterol Δ24-reductase (DHCR24/Seladin-1) in CHO-7 and SRD-1 cells when used at a concentration of 2.5 μM.{43944}
Brand:CaymanSKU:10131 - 1 mgAvailable on backorder
24α-ethyl Cholesterol is a naturally occurring plant sterol with antioxidant, anticancer, anti-inflammatory, angiogenic, chemopreventive, and immunomodulatory activities. It inhibits the absorption of dietary and endogenously-produced cholesterol from the small intestine, reducing blood cholesterol concentrations.{21230} Because of its nutraceutical benefits, 24α-ethyl cholesterol has been used as a food additive intended to lower LDL cholesterol.{21230,21231} 24α-ethyl Cholesterol (0.1 – 100 μM) can dose-dependently induce adipogenesis and lipolysis in rat primary preadipocytes as well as stimulate glucose uptake in differentiated adipocytes.{21231}
Brand:CaymanSKU:11756 - 10 gAvailable on backorder
24α-ethyl Cholesterol is a naturally occurring plant sterol with antioxidant, anticancer, anti-inflammatory, angiogenic, chemopreventive, and immunomodulatory activities. It inhibits the absorption of dietary and endogenously-produced cholesterol from the small intestine, reducing blood cholesterol concentrations.{21230} Because of its nutraceutical benefits, 24α-ethyl cholesterol has been used as a food additive intended to lower LDL cholesterol.{21230,21231} 24α-ethyl Cholesterol (0.1 – 100 μM) can dose-dependently induce adipogenesis and lipolysis in rat primary preadipocytes as well as stimulate glucose uptake in differentiated adipocytes.{21231}
Brand:CaymanSKU:11756 - 25 gAvailable on backorder
24α-ethyl Cholesterol is a naturally occurring plant sterol with antioxidant, anticancer, anti-inflammatory, angiogenic, chemopreventive, and immunomodulatory activities. It inhibits the absorption of dietary and endogenously-produced cholesterol from the small intestine, reducing blood cholesterol concentrations.{21230} Because of its nutraceutical benefits, 24α-ethyl cholesterol has been used as a food additive intended to lower LDL cholesterol.{21230,21231} 24α-ethyl Cholesterol (0.1 – 100 μM) can dose-dependently induce adipogenesis and lipolysis in rat primary preadipocytes as well as stimulate glucose uptake in differentiated adipocytes.{21231}
Brand:CaymanSKU:11756 - 5 gAvailable on backorder
24α-methyl Cholesterol is a phytosterol found in vegetables, fruits, nuts, and seeds that competitively inhibits the absorption of intestinal cholesterol and decreases the transcription of genes important for cholesterol metabolism.{28271} The cholesterol lowering effects of phytosterols, such as 24α-methyl cholesterol, have been reported to be beneficial for lowering the incidence of atherosclerotic plaques.{20083} 24α-methyl Cholesterol can also act as an agonist at liver X receptors (LXR) and, through activation of LXR signaling, has been shown to suppress the proliferation of prostate and breast cancer cells.{15405}
Brand:CaymanSKU:-Available on backorder
24α-methyl Cholesterol is a phytosterol found in vegetables, fruits, nuts, and seeds that competitively inhibits the absorption of intestinal cholesterol and decreases the transcription of genes important for cholesterol metabolism.{28271} The cholesterol lowering effects of phytosterols, such as 24α-methyl cholesterol, have been reported to be beneficial for lowering the incidence of atherosclerotic plaques.{20083} 24α-methyl Cholesterol can also act as an agonist at liver X receptors (LXR) and, through activation of LXR signaling, has been shown to suppress the proliferation of prostate and breast cancer cells.{15405}
Brand:CaymanSKU:-Available on backorder
25-hydroxy Cholesterol is an oxysterol.{20437} It is formed from cholesterol by cholesterol-25-hydroxylase, and its production can be induced by inflammation or infection.{60052} 25-hydroxy Cholesterol suppresses endogenous cholesterol synthesis by binding to insulin-induced gene (INSIG) proteins and preventing sterol regulatory element binding proteins (SREBPs) from being transported to the Golgi. It inhibits IgA class switching induced by LPS and various cytokines in B cells (IC50 = ~50 nM).{20445} 25-hydroxy Cholesterol inhibits replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero cells (EC50 = 3.675 µM) and reduces increases in viral protein production in infected Vero cells when used prior to infection.{60053} It reduces viral RNA loads in the lung and trachea in a mouse model of SARS-CoV-2 infection when administered at a dose of 100 mg/kg per day. Serum levels of 25-hydroxy cholesterol are increased in mice expressing human angiotensin-converting enzyme 2 (hACE2), the functional receptor for SARS-CoV-2, in a model of SARS-CoV-2 infection and in a patient with COVID-19, the primarily respiratory disease caused by SARS-CoV-2.
Brand:CaymanSKU:11097 - 10 mgAvailable on backorder
25-hydroxy Cholesterol is an oxysterol.{20437} It is formed from cholesterol by cholesterol-25-hydroxylase, and its production can be induced by inflammation or infection.{60052} 25-hydroxy Cholesterol suppresses endogenous cholesterol synthesis by binding to insulin-induced gene (INSIG) proteins and preventing sterol regulatory element binding proteins (SREBPs) from being transported to the Golgi. It inhibits IgA class switching induced by LPS and various cytokines in B cells (IC50 = ~50 nM).{20445} 25-hydroxy Cholesterol inhibits replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero cells (EC50 = 3.675 µM) and reduces increases in viral protein production in infected Vero cells when used prior to infection.{60053} It reduces viral RNA loads in the lung and trachea in a mouse model of SARS-CoV-2 infection when administered at a dose of 100 mg/kg per day. Serum levels of 25-hydroxy cholesterol are increased in mice expressing human angiotensin-converting enzyme 2 (hACE2), the functional receptor for SARS-CoV-2, in a model of SARS-CoV-2 infection and in a patient with COVID-19, the primarily respiratory disease caused by SARS-CoV-2.
Brand:CaymanSKU:11097 - 100 mgAvailable on backorder
25-hydroxy Cholesterol is an oxysterol.{20437} It is formed from cholesterol by cholesterol-25-hydroxylase, and its production can be induced by inflammation or infection.{60052} 25-hydroxy Cholesterol suppresses endogenous cholesterol synthesis by binding to insulin-induced gene (INSIG) proteins and preventing sterol regulatory element binding proteins (SREBPs) from being transported to the Golgi. It inhibits IgA class switching induced by LPS and various cytokines in B cells (IC50 = ~50 nM).{20445} 25-hydroxy Cholesterol inhibits replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero cells (EC50 = 3.675 µM) and reduces increases in viral protein production in infected Vero cells when used prior to infection.{60053} It reduces viral RNA loads in the lung and trachea in a mouse model of SARS-CoV-2 infection when administered at a dose of 100 mg/kg per day. Serum levels of 25-hydroxy cholesterol are increased in mice expressing human angiotensin-converting enzyme 2 (hACE2), the functional receptor for SARS-CoV-2, in a model of SARS-CoV-2 infection and in a patient with COVID-19, the primarily respiratory disease caused by SARS-CoV-2.
Brand:CaymanSKU:11097 - 25 mgAvailable on backorder
25-hydroxy Cholesterol is an oxysterol.{20437} It is formed from cholesterol by cholesterol-25-hydroxylase, and its production can be induced by inflammation or infection.{60052} 25-hydroxy Cholesterol suppresses endogenous cholesterol synthesis by binding to insulin-induced gene (INSIG) proteins and preventing sterol regulatory element binding proteins (SREBPs) from being transported to the Golgi. It inhibits IgA class switching induced by LPS and various cytokines in B cells (IC50 = ~50 nM).{20445} 25-hydroxy Cholesterol inhibits replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero cells (EC50 = 3.675 µM) and reduces increases in viral protein production in infected Vero cells when used prior to infection.{60053} It reduces viral RNA loads in the lung and trachea in a mouse model of SARS-CoV-2 infection when administered at a dose of 100 mg/kg per day. Serum levels of 25-hydroxy cholesterol are increased in mice expressing human angiotensin-converting enzyme 2 (hACE2), the functional receptor for SARS-CoV-2, in a model of SARS-CoV-2 infection and in a patient with COVID-19, the primarily respiratory disease caused by SARS-CoV-2.
Brand:CaymanSKU:11097 - 5 mgAvailable on backorder
25-hydroxy Cholesterol contains six deuterium atoms at the 26, 26, 26, 27, 27, and 27 positions. It is intended for use as an internal standard for the quantification of 25-hydroxy cholesterol by GC- or LC-mass spectrometry. 25-hydroxy Cholesterol is a side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in various cell types.{20437} It has been implicated in a variety of metabolic events including cholesterol homeostasis and atherosclerosis as well as antitumor activities as it has been shown to induce apoptosis through down-regulation of Bcl-2 expression and activation of caspases.{20436} Immunomodulating capabilities have also been observed as the oxysterol can act as a LXR-RXR ligand coupling cholesterol synthesis to T cell proliferation, can reduce (EC50 ~ 65 nM) IgA production by B cells in response to IL-2, and can suppress differentiation of monocytes into macrophages.{20444,20445,20446}
Brand:CaymanSKU:11099 - 1 mgAvailable on backorder
25-hydroxy Cholesterol contains six deuterium atoms at the 26, 26, 26, 27, 27, and 27 positions. It is intended for use as an internal standard for the quantification of 25-hydroxy cholesterol by GC- or LC-mass spectrometry. 25-hydroxy Cholesterol is a side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in various cell types.{20437} It has been implicated in a variety of metabolic events including cholesterol homeostasis and atherosclerosis as well as antitumor activities as it has been shown to induce apoptosis through down-regulation of Bcl-2 expression and activation of caspases.{20436} Immunomodulating capabilities have also been observed as the oxysterol can act as a LXR-RXR ligand coupling cholesterol synthesis to T cell proliferation, can reduce (EC50 ~ 65 nM) IgA production by B cells in response to IL-2, and can suppress differentiation of monocytes into macrophages.{20444,20445,20446}
Brand:CaymanSKU:11099 - 5 mgAvailable on backorder
25-hydroxy Cholesterol contains six deuterium atoms at the 26, 26, 26, 27, 27, and 27 positions. It is intended for use as an internal standard for the quantification of 25-hydroxy cholesterol by GC- or LC-mass spectrometry. 25-hydroxy Cholesterol is a side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in various cell types.{20437} It has been implicated in a variety of metabolic events including cholesterol homeostasis and atherosclerosis as well as antitumor activities as it has been shown to induce apoptosis through down-regulation of Bcl-2 expression and activation of caspases.{20436} Immunomodulating capabilities have also been observed as the oxysterol can act as a LXR-RXR ligand coupling cholesterol synthesis to T cell proliferation, can reduce (EC50 ~ 65 nM) IgA production by B cells in response to IL-2, and can suppress differentiation of monocytes into macrophages.{20444,20445,20446}
Brand:CaymanSKU:11099 - 500 µgAvailable on backorder
Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity.{15096,19429} Vitamin D2 is produced in fungi, including yeast, from ergosterol in response to ultraviolet radiation. 25-hydroxy Vitamin D2 is an intermediate produced from vitamin D2 by cytochrome P450 isoforms in vertebrates. It is subsequently metabolized to 1,25-dihydroxy vitamin D2, which is an agonist for the vitamin D receptor.{21565}
Brand:CaymanSKU:12078 - 1 mgAvailable on backorder
Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity.{15096,19429} Vitamin D2 is produced in fungi, including yeast, from ergosterol in response to ultraviolet radiation. 25-hydroxy Vitamin D2 is an intermediate produced from vitamin D2 by cytochrome P450 isoforms in vertebrates. It is subsequently metabolized to 1,25-dihydroxy vitamin D2, which is an agonist for the vitamin D receptor.{21565}
Brand:CaymanSKU:12078 - 5 mgAvailable on backorder
Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity.{15096,19429} Vitamin D2 is produced in fungi, including yeast, from ergosterol in response to ultraviolet radiation. 25-hydroxy Vitamin D2 is an intermediate produced from vitamin D2 by cytochrome P450 isoforms in vertebrates. It is subsequently metabolized to 1,25-dihydroxy vitamin D2, which is an agonist for the vitamin D receptor.{21565}
Brand:CaymanSKU:12078 - 500 µgAvailable on backorder
Deficiency of vitamin D leads to abnormal calcium and phosphorus metabolism, contributing to deficiencies in bone formation, neuromuscular function, and inflammatory response. 25-hydroxy Vitamin D3 is an intermediate in the pathway leading to the production of 1,25-dihydroxy vitamin D3, the most receptor-active form of vitamin D. 25-hydroxy Vitamin D3, produced in the liver from vitamin D3, is metabolized in the kidney to 1,25-dihydroxy vitamin D3. Plasma or serum levels of 25-hydroxy vitamin D3 are commonly used as an indicator of an individual’s vitamin D status.{19429}
Brand:CaymanSKU:9000683 - 1 mgAvailable on backorder
Deficiency of vitamin D leads to abnormal calcium and phosphorus metabolism, contributing to deficiencies in bone formation, neuromuscular function, and inflammatory response. 25-hydroxy Vitamin D3 is an intermediate in the pathway leading to the production of 1,25-dihydroxy vitamin D3, the most receptor-active form of vitamin D. 25-hydroxy Vitamin D3, produced in the liver from vitamin D3, is metabolized in the kidney to 1,25-dihydroxy vitamin D3. Plasma or serum levels of 25-hydroxy vitamin D3 are commonly used as an indicator of an individual’s vitamin D status.{19429}
Brand:CaymanSKU:9000683 - 10 mgAvailable on backorder
Deficiency of vitamin D leads to abnormal calcium and phosphorus metabolism, contributing to deficiencies in bone formation, neuromuscular function, and inflammatory response. 25-hydroxy Vitamin D3 is an intermediate in the pathway leading to the production of 1,25-dihydroxy vitamin D3, the most receptor-active form of vitamin D. 25-hydroxy Vitamin D3, produced in the liver from vitamin D3, is metabolized in the kidney to 1,25-dihydroxy vitamin D3. Plasma or serum levels of 25-hydroxy vitamin D3 are commonly used as an indicator of an individual’s vitamin D status.{19429}
Brand:CaymanSKU:9000683 - 5 mgAvailable on backorder
25-hydroxy Vitamin D3 3,3′-aminopropyl ether is an analog of vitamin D3 (Item No. 11792).{38277} It contains a highly reactive amine group that can be coupled to a sepharose matrix for affinity purification of vitamin D binding protein. 25-hydroxy Vitamin D3 3,3′-aminopropyl ether also inhibits 25-hydroxy vitamin D3-1α-hydroxylase.
Brand:CaymanSKU:23122 - 1 mgAvailable on backorder
25-hydroxy Vitamin D3 3,3′-aminopropyl ether is an analog of vitamin D3 (Item No. 11792).{38277} It contains a highly reactive amine group that can be coupled to a sepharose matrix for affinity purification of vitamin D binding protein. 25-hydroxy Vitamin D3 3,3′-aminopropyl ether also inhibits 25-hydroxy vitamin D3-1α-hydroxylase.
Brand:CaymanSKU:23122 - 10 mgAvailable on backorder
25-hydroxy Vitamin D3 3,3′-aminopropyl ether is an analog of vitamin D3 (Item No. 11792).{38277} It contains a highly reactive amine group that can be coupled to a sepharose matrix for affinity purification of vitamin D binding protein. 25-hydroxy Vitamin D3 3,3′-aminopropyl ether also inhibits 25-hydroxy vitamin D3-1α-hydroxylase.
Brand:CaymanSKU:23122 - 5 mgAvailable on backorder
Brand:CaymanSKU:401054 - 1.250 µgAvailable on backorder
Immunogen: 25-hydroxy Vitamin D3-BSA conjugate • Host: Rabbit • Species Reactivity: Species independent • Cross Reactivity: (+) 25-hydroxy Vitamin D3, 1α,25-hydroxy vitamin D3; (-) Vitamin D3, vitamin D2, 25-hydroxy vitamin D2, 1α,25-hydroxy vitamin D2 • Applications: ELISA ,,
Brand:CaymanSKU:32179- 100 µlAvailable on backorder
Immunogen: 25-hydroxy Vitamin D3-BSA conjugate • Host: Rabbit • Species Reactivity: Species independent • Cross Reactivity: (+) 25-hydroxy Vitamin D3, 1α,25-hydroxy vitamin D3; (-) Vitamin D3, vitamin D2, 25-hydroxy vitamin D2, 1α,25-hydroxy vitamin D2 • Applications: ELISA ,,
Brand:CaymanSKU:32179- 100 µl 25-hydroxy Vitamin D3 is an intermediate in the biosynthesis of 1α,25-dihydroxy vitamin D3 (calcitriol; Item No. 71820), a vitamin D receptor (VDR) agonist that has multiple functions, including stimulation of calcium absorption, insulin secretion, and cell proliferation and differentiation.{60080,60081,60082} It is produced from vitamin D3 (Item No. 11792) by 25-hydroxylase/CYP2R1 and bound to vitamin D binding protein (DBP) and albumin in the liver, then secreted into the bloodstream where it is the major circulating form of vitamin D.{60080} 25-hydroxy Vitamin D3 is transported to the kidney where it is hydroxylated by 1α-hydroxylase/CYP27B1 or 24-hydroxylase/CYP24A1 to produce 1α,25-dihydroxy vitamin D3 or 24,25-dihydroxy vitamin D3, respectively. Conversion of 25-hydroxy vitamin D3 to 1α,25-dihydroxy vitamin D3 is stimulated by parathyroid hormone (PTH) and inhibited by calcium, phosphorus, or FGF23. Serum 25-hydroxy vitamin D3 levels have been widely used as a marker of vitamin D status.{60081} Increased serum 25-hydroxy vitamin D3 levels are associated with increased bone density in patients with osteoarthritis, as well as reduced risk of colorectal, breast, and prostate cancer, whereas decreased serum 25-hydroxy vitamin D3 levels have been found in children with nutritional rickets, a condition caused by vitamin D deficiency and characterized by reduced bone density.{60081,60083,60084} Cayman’s 25-hydroxy Vitamin D3 Rabbit Monoclonal Antibody can be used for ELISA.
Brand:CaymanSKU:32179 - 100 µlAvailable on backorder
The liver X receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism.{12040} 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRα and LXRβ in vitro with EC50 values of 85 and 71 nM, respectively, and is a potent suppressor of cholesterol biosynthesis.{13891,23747} 25(R)-27-hydroxy Cholesterol is the more predominant-occurring (~80%) stereoisomer of the endogenous oxysterol 27-hydroxy cholesterol.{23746,23745}
Brand:CaymanSKU:- The liver X receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism.{12040} 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRα and LXRβ in vitro with EC50 values of 85 and 71 nM, respectively, and is a potent suppressor of cholesterol biosynthesis.{13891,23747} 25(R)-27-hydroxy Cholesterol is the more predominant-occurring (~80%) stereoisomer of the endogenous oxysterol 27-hydroxy cholesterol.{23746,23745}
Brand:CaymanSKU:- The liver X receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism.{12040} 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRα and LXRβ in vitro with EC50 values of 85 and 71 nM, respectively, and is a potent suppressor of cholesterol biosynthesis.{13891,23747} 25(R)-27-hydroxy Cholesterol is the more predominant-occurring (~80%) stereoisomer of the endogenous oxysterol 27-hydroxy cholesterol.{23746,23745}
Brand:CaymanSKU:-
The liver x receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism.{12040} 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRα and LXRβ in vitro with EC50 values of 85 and 71 nM, respectively, and is a potent suppressor of cholesterol biosynthesis.{13891,23747} 25(S)-27 hydroxy Cholesterol is the less predominant-occurring (~20%) stereoisomer of the endogenous oxysterol 27-hydroxy cholesterol.{23746,23745}
Brand:CaymanSKU:- The liver x receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism.{12040} 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRα and LXRβ in vitro with EC50 values of 85 and 71 nM, respectively, and is a potent suppressor of cholesterol biosynthesis.{13891,23747} 25(S)-27 hydroxy Cholesterol is the less predominant-occurring (~20%) stereoisomer of the endogenous oxysterol 27-hydroxy cholesterol.{23746,23745}
Brand:CaymanSKU:- The liver x receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism.{12040} 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRα and LXRβ in vitro with EC50 values of 85 and 71 nM, respectively, and is a potent suppressor of cholesterol biosynthesis.{13891,23747} 25(S)-27 hydroxy Cholesterol is the less predominant-occurring (~20%) stereoisomer of the endogenous oxysterol 27-hydroxy cholesterol.{23746,23745}
Brand:CaymanSKU:-
25B-NB3OMe (hydrochloride) (Item No. 19364) is an analytical reference standard that is structurally categorized as a phenethylamine. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:-Available on backorder
25B-NB3OMe (hydrochloride) (Item No. 19364) is an analytical reference standard that is structurally categorized as a phenethylamine. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:-Available on backorder
25B-NB4OMe (hydrochloride) (Item No. 13499) is an analytical reference standard that is structurally categorized as a phenethylamine. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:-Available on backorder
25B-NB4OMe (hydrochloride) (Item No. 13499) is an analytical reference standard that is structurally categorized as a phenethylamine. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:-Available on backorder
25B-NBF is an N-fluorobenzyl derivative of the phenethylamine hallucinogen 2C-B (Item No. 11734), which acts as a highly potent agonist for the 5-HT2C receptor. 25B-NBF binds human 5-HT2A receptors and rat 5-HT2C receptors with pKi values of 8.57 and 7.73, respectively.{26036} This product is intended for forensic and research applications.
Brand:CaymanSKU:- 25B-NBF is an N-fluorobenzyl derivative of the phenethylamine hallucinogen 2C-B (Item No. 11734), which acts as a highly potent agonist for the 5-HT2C receptor. 25B-NBF binds human 5-HT2A receptors and rat 5-HT2C receptors with pKi values of 8.57 and 7.73, respectively.{26036} This product is intended for forensic and research applications.
Brand:CaymanSKU:- 25B-NBF is an N-fluorobenzyl derivative of the phenethylamine hallucinogen 2C-B (Item No. 11734), which acts as a highly potent agonist for the 5-HT2C receptor. 25B-NBF binds human 5-HT2A receptors and rat 5-HT2C receptors with pKi values of 8.57 and 7.73, respectively.{26036} This product is intended for forensic and research applications.
Brand:CaymanSKU:-
2C-B is a hallucinogenic designer drug which potently activates the serotonin receptor 5-HT2C (pEC50 = 6.8 for arachidonic acid release).{20772} 25B-NBOMe is a derivative of 2C-B, characterized by the addition of a benzyl-methoxy (BOMe) group to the amine. This N-(2-methoxybenzyl) addition significantly increases the affinity (Ki = 1.01 nM) and activity (ED50 = 0.51 nM) at the serotonin receptor 5-HT2A.{21331} This product is intended for research and forensic applications.
Brand:CaymanSKU:-
25C-NB3OMe (hydrochloride) (Item No. 18560) is an analytical reference standard that is structurally categorized as a phenethylamine. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:-Available on backorder
25C-NB3OMe (hydrochloride) (Item No. 18560) is an analytical reference standard that is structurally categorized as a phenethylamine. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:-Available on backorder
25C-NB3OMe (hydrochloride) (Item No. 18560) is an analytical reference standard that is structurally categorized as a phenethylamine. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:-Available on backorder
25C-NB4OMe (hydrochloride) (Item No. 27337) is an analytical reference standard categorized as a phenethylamine.{31169} This product is intended for research and forensic applications.
Brand:CaymanSKU:27337 - 1 mgAvailable on backorder
25C-NB4OMe (hydrochloride) (Item No. 27337) is an analytical reference standard categorized as a phenethylamine.{31169} This product is intended for research and forensic applications.
Brand:CaymanSKU:27337 - 5 mgAvailable on backorder
2C-C (Item No. 11735) is a 2,5-dimethoxyphenethylamine with a chlorine atom at the four position of the aromatic ring. A known hallucinogen, this compound stimulates monoamine receptor activity while inhibiting the re-uptake of serotonin (Item No. 14332) and norepinephrine.{19271,19758} 25C-NBF (hydrochloride) is a derivative of 2C-C having an N-(2-fluorobenzyl) addition at the amine. It is an agonist of serotonin receptors that activates 5-HT2A and 5-HT2C similarly (EC50s = ~0.3 µM for each).{26036} This product is intended for forensic and research applications.
Brand:CaymanSKU:- 2C-C (Item No. 11735) is a 2,5-dimethoxyphenethylamine with a chlorine atom at the four position of the aromatic ring. A known hallucinogen, this compound stimulates monoamine receptor activity while inhibiting the re-uptake of serotonin (Item No. 14332) and norepinephrine.{19271,19758} 25C-NBF (hydrochloride) is a derivative of 2C-C having an N-(2-fluorobenzyl) addition at the amine. It is an agonist of serotonin receptors that activates 5-HT2A and 5-HT2C similarly (EC50s = ~0.3 µM for each).{26036} This product is intended for forensic and research applications.
Brand:CaymanSKU:- 2C-C (Item No. 11735) is a 2,5-dimethoxyphenethylamine with a chlorine atom at the four position of the aromatic ring. A known hallucinogen, this compound stimulates monoamine receptor activity while inhibiting the re-uptake of serotonin (Item No. 14332) and norepinephrine.{19271,19758} 25C-NBF (hydrochloride) is a derivative of 2C-C having an N-(2-fluorobenzyl) addition at the amine. It is an agonist of serotonin receptors that activates 5-HT2A and 5-HT2C similarly (EC50s = ~0.3 µM for each).{26036} This product is intended for forensic and research applications.
Brand:CaymanSKU:-
2C-C (Item No. 11735) is a 2,5-dimethoxyphenethylamine with a chlorine atom at the four position of the aromatic ring. A known hallucinogen, this compound stimulates monoamine receptor activity while inhibiting the re-uptake of serotonin (Item No. 14332) and norepinephrine.{19271,19758} 25C-NBOH is a derivative of 2C-C having an N-(2-hydroxybenzyl) addition at the amine. It is a potent agonist of serotonin receptors that shows selectivity for 5-HT2A over 5-HT2C (EC50s = ~ 0.40 and 15 nM, respectively).{26036} This product is intended for forensic and research applications.
Brand:CaymanSKU:- 2C-C (Item No. 11735) is a 2,5-dimethoxyphenethylamine with a chlorine atom at the four position of the aromatic ring. A known hallucinogen, this compound stimulates monoamine receptor activity while inhibiting the re-uptake of serotonin (Item No. 14332) and norepinephrine.{19271,19758} 25C-NBOH is a derivative of 2C-C having an N-(2-hydroxybenzyl) addition at the amine. It is a potent agonist of serotonin receptors that shows selectivity for 5-HT2A over 5-HT2C (EC50s = ~ 0.40 and 15 nM, respectively).{26036} This product is intended for forensic and research applications.
Brand:CaymanSKU:- 2C-C (Item No. 11735) is a 2,5-dimethoxyphenethylamine with a chlorine atom at the four position of the aromatic ring. A known hallucinogen, this compound stimulates monoamine receptor activity while inhibiting the re-uptake of serotonin (Item No. 14332) and norepinephrine.{19271,19758} 25C-NBOH is a derivative of 2C-C having an N-(2-hydroxybenzyl) addition at the amine. It is a potent agonist of serotonin receptors that shows selectivity for 5-HT2A over 5-HT2C (EC50s = ~ 0.40 and 15 nM, respectively).{26036} This product is intended for forensic and research applications.
Brand:CaymanSKU:-
2C-C is a 2,5-dimethoxyphenethylamine with a chlorine atom at the four position of the aromatic ring. A known hallucinogen, this compound stimulates monoamine receptor activity and inhibits the re-uptake of serotonin (Item No. 14332) and norepinephrine in rat brain synaptosomes (IC50s = 31 and 63 μM, respectively).{19271,19758} 25C-NBOMe is a derivative of 2C-C having an N-(2-methoxybenzyl) addition at the amine. This addition increases the affinity and selectivity for the 5-HT2A receptor over other serotonin receptors.{20442} Radiolabeled 25C-NBOMe has been used for positron emission tomography imaging of the 5-HT2A receptor in porcine brain.{21331} This product is intended for forensic and research uses.
Brand:CaymanSKU:-
2C-D (Item No. 11888), a 2,5-dimethoxy phenethylamine, is designer drug with mild hallucinogenic activity, due in part to weak activity at serotonin receptors.{19963,20772} 25D-NBOMe is a derivative of 2C-D, characterized by the addition of a benzyl-methoxy (BOMe) group to the amine. While the properties of this compound are not known, the N-(2-methoxybenzyl) addition significantly increases the affinity and activity of other disubstituted phenethylamines at the serotonin receptor 5-HT2A.{20442,20443} This product is intended for research and forensic applications.
Brand:CaymanSKU:11946 - 1 mgAvailable on backorder
2C-D (Item No. 11888), a 2,5-dimethoxy phenethylamine, is designer drug with mild hallucinogenic activity, due in part to weak activity at serotonin receptors.{19963,20772} 25D-NBOMe is a derivative of 2C-D, characterized by the addition of a benzyl-methoxy (BOMe) group to the amine. While the properties of this compound are not known, the N-(2-methoxybenzyl) addition significantly increases the affinity and activity of other disubstituted phenethylamines at the serotonin receptor 5-HT2A.{20442,20443} This product is intended for research and forensic applications.
Brand:CaymanSKU:11946 - 10 mgAvailable on backorder
2C-D (Item No. 11888), a 2,5-dimethoxy phenethylamine, is designer drug with mild hallucinogenic activity, due in part to weak activity at serotonin receptors.{19963,20772} 25D-NBOMe is a derivative of 2C-D, characterized by the addition of a benzyl-methoxy (BOMe) group to the amine. While the properties of this compound are not known, the N-(2-methoxybenzyl) addition significantly increases the affinity and activity of other disubstituted phenethylamines at the serotonin receptor 5-HT2A.{20442,20443} This product is intended for research and forensic applications.
Brand:CaymanSKU:11946 - 5 mgAvailable on backorder
2C-D (Item No. 11888), a 2,5-dimethoxy phenethylamine, is designer drug with mild hallucinogenic activity, due in part to weak activity at serotonin receptors.{19963,20772} 25D-NBOMe is a derivative of 2C-D, characterized by the addition of a benzyl-methoxy (BOMe) group to the amine. While the properties of this compound are not known, the N-(2-methoxybenzyl) addition significantly increases the affinity and activity of other disubstituted phenethylamines at the serotonin receptor 5-HT2A.{20442,20443} This product is intended for research and forensic applications.
Brand:CaymanSKU:11946 - 50 mgAvailable on backorder
25E-NBOH (hydrochloride) (Item No. 20075) is an analytical reference standard categorized as a phenethylamine.{26036} This product is intended for research and forensic applications.
Brand:CaymanSKU:20075 -Available on backorder
25E-NBOH (hydrochloride) (Item No. 20075) is an analytical reference standard categorized as a phenethylamine.{26036} This product is intended for research and forensic applications.
Brand:CaymanSKU:20075 -Available on backorder
2C-E, known formally as 2,5-dimethoxy-4-ethyl phenethylamine, is a psychoactive compound that is regulated as Schedule I in the United States.{22700,24049} 25E-NBOMe is a derivative of 2C-E having an N-(2-methoxybenzyl) addition at the amine. This addition on related phenethylamines increases the affinity and selectivity for the 5-HT2A receptor over other serotonin receptors.{20442} This product is intended for forensic and research purposes.
Brand:CaymanSKU:- 2C-E, known formally as 2,5-dimethoxy-4-ethyl phenethylamine, is a psychoactive compound that is regulated as Schedule I in the United States.{22700,24049} 25E-NBOMe is a derivative of 2C-E having an N-(2-methoxybenzyl) addition at the amine. This addition on related phenethylamines increases the affinity and selectivity for the 5-HT2A receptor over other serotonin receptors.{20442} This product is intended for forensic and research purposes.
Brand:CaymanSKU:- 2C-E, known formally as 2,5-dimethoxy-4-ethyl phenethylamine, is a psychoactive compound that is regulated as Schedule I in the United States.{22700,24049} 25E-NBOMe is a derivative of 2C-E having an N-(2-methoxybenzyl) addition at the amine. This addition on related phenethylamines increases the affinity and selectivity for the 5-HT2A receptor over other serotonin receptors.{20442} This product is intended for forensic and research purposes.
Brand:CaymanSKU:- 2C-E, known formally as 2,5-dimethoxy-4-ethyl phenethylamine, is a psychoactive compound that is regulated as Schedule I in the United States.{22700,24049} 25E-NBOMe is a derivative of 2C-E having an N-(2-methoxybenzyl) addition at the amine. This addition on related phenethylamines increases the affinity and selectivity for the 5-HT2A receptor over other serotonin receptors.{20442} This product is intended for forensic and research purposes.
Brand:CaymanSKU:-
A series of 2,5-phenethylamines, collectively referred to as 2Cs, have psychoactive effects including potent activation of serotonin receptors and many are scheduled as illegal substances.{20772,19963} 25G-NBOMe (hydrochloride) is a derivative of 2C-G, characterized by the addition of a benzyl-methoxy (BOMe) group to the amine.{22984} While the properties of this compound are not known, the N-(2-methoxybenzyl) addition significantly increases the affinity and activity of other disubstituted phenethylamines at the 5-HT2A serotonin receptor.{20442,20443} This product is intended for research and forensic applications.
Brand:CaymanSKU:- A series of 2,5-phenethylamines, collectively referred to as 2Cs, have psychoactive effects including potent activation of serotonin receptors and many are scheduled as illegal substances.{20772,19963} 25G-NBOMe (hydrochloride) is a derivative of 2C-G, characterized by the addition of a benzyl-methoxy (BOMe) group to the amine.{22984} While the properties of this compound are not known, the N-(2-methoxybenzyl) addition significantly increases the affinity and activity of other disubstituted phenethylamines at the 5-HT2A serotonin receptor.{20442,20443} This product is intended for research and forensic applications.
Brand:CaymanSKU:- A series of 2,5-phenethylamines, collectively referred to as 2Cs, have psychoactive effects including potent activation of serotonin receptors and many are scheduled as illegal substances.{20772,19963} 25G-NBOMe (hydrochloride) is a derivative of 2C-G, characterized by the addition of a benzyl-methoxy (BOMe) group to the amine.{22984} While the properties of this compound are not known, the N-(2-methoxybenzyl) addition significantly increases the affinity and activity of other disubstituted phenethylamines at the 5-HT2A serotonin receptor.{20442,20443} This product is intended for research and forensic applications.
Brand:CaymanSKU:-
25H-NB4OMe (hydrochloride) (Item No. 19365) is an analytical reference standard that is structurally categorized as a phenethylamine. The biological properties of this compound have not been evaluated, although mass spectra characterization has been reported.{31169} This product is intended for research and forensic applications.
Brand:CaymanSKU:-Available on backorder
25H-NB4OMe (hydrochloride) (Item No. 19365) is an analytical reference standard that is structurally categorized as a phenethylamine. The biological properties of this compound have not been evaluated, although mass spectra characterization has been reported.{31169} This product is intended for research and forensic applications.
Brand:CaymanSKU:-Available on backorder
25H-NB4OMe (hydrochloride) (Item No. 19365) is an analytical reference standard that is structurally categorized as a phenethylamine. The biological properties of this compound have not been evaluated, although mass spectra characterization has been reported.{31169} This product is intended for research and forensic applications.
Brand:CaymanSKU:-Available on backorder
25H-NB4OMe (hydrochloride) (Item No. 19365) is an analytical reference standard that is structurally categorized as a phenethylamine. The biological properties of this compound have not been evaluated, although mass spectra characterization has been reported.{31169} This product is intended for research and forensic applications.
Brand:CaymanSKU:-Available on backorder
2C-H, also known as 25H or 2,5-dimethoxyphenethylamine, (Item No. 11889) is a phenethylamine that has little effect on serotonin receptors, activating the 5-HT2C receptor to 20% that induced by serotonin (pEC50 = 5.93).{20772} The addition of N-(2-methoxybenzyl) at the amine increases the affinity for the 5-HT2A receptor over other serotonin receptors (Ki values for 25H and 25H-NBOMe are 227 and 1.19 nM, respectively).{20442} 25H-NBOMe imine analog differs from 25H-NBOMe by having a double bond linking the N-(2-methoxybenzyl) group to 25H. The properties of this compound have not been evaluated. This product is intended for research and forensic applications.
Brand:CaymanSKU:12062 - 1 mgAvailable on backorder
2C-H, also known as 25H or 2,5-dimethoxyphenethylamine, (Item No. 11889) is a phenethylamine that has little effect on serotonin receptors, activating the 5-HT2C receptor to 20% that induced by serotonin (pEC50 = 5.93).{20772} The addition of N-(2-methoxybenzyl) at the amine increases the affinity for the 5-HT2A receptor over other serotonin receptors (Ki values for 25H and 25H-NBOMe are 227 and 1.19 nM, respectively).{20442} 25H-NBOMe imine analog differs from 25H-NBOMe by having a double bond linking the N-(2-methoxybenzyl) group to 25H. The properties of this compound have not been evaluated. This product is intended for research and forensic applications.
Brand:CaymanSKU:12062 - 10 mgAvailable on backorder
2C-H, also known as 25H or 2,5-dimethoxyphenethylamine, (Item No. 11889) is a phenethylamine that has little effect on serotonin receptors, activating the 5-HT2C receptor to 20% that induced by serotonin (pEC50 = 5.93).{20772} The addition of N-(2-methoxybenzyl) at the amine increases the affinity for the 5-HT2A receptor over other serotonin receptors (Ki values for 25H and 25H-NBOMe are 227 and 1.19 nM, respectively).{20442} 25H-NBOMe imine analog differs from 25H-NBOMe by having a double bond linking the N-(2-methoxybenzyl) group to 25H. The properties of this compound have not been evaluated. This product is intended for research and forensic applications.
Brand:CaymanSKU:12062 - 5 mgAvailable on backorder
25I-NBF is an N-benzyl derivative of the phenethylamine hallucinogen 2C-I which acts as a highly potent partial agonist for the 5-HT2A receptor. 25I-NBF acts as a partial agonist of human 5-HT2A receptors demonstrating a Ki value of 0.26 nM and an EC50 value of 1.6 nM.{20442} A radiolabelled form of 25I-NBF has been used for mapping the distribution of 5-HT2A receptors in the brain, using positron emission tomography.{21331} This product is intended for forensic and research applications.
Brand:CaymanSKU:- 25I-NBF is an N-benzyl derivative of the phenethylamine hallucinogen 2C-I which acts as a highly potent partial agonist for the 5-HT2A receptor. 25I-NBF acts as a partial agonist of human 5-HT2A receptors demonstrating a Ki value of 0.26 nM and an EC50 value of 1.6 nM.{20442} A radiolabelled form of 25I-NBF has been used for mapping the distribution of 5-HT2A receptors in the brain, using positron emission tomography.{21331} This product is intended for forensic and research applications.
Brand:CaymanSKU:- 25I-NBF is an N-benzyl derivative of the phenethylamine hallucinogen 2C-I which acts as a highly potent partial agonist for the 5-HT2A receptor. 25I-NBF acts as a partial agonist of human 5-HT2A receptors demonstrating a Ki value of 0.26 nM and an EC50 value of 1.6 nM.{20442} A radiolabelled form of 25I-NBF has been used for mapping the distribution of 5-HT2A receptors in the brain, using positron emission tomography.{21331} This product is intended for forensic and research applications.
Brand:CaymanSKU:-