Cayman

Showing 4651–4800 of 45550 results

  • 2,3-Dichlorophenylpiperazine is an analog of 3-chlorophenylpiperazine, a psychoactive drug of abuse.{20497,21515,19874} The physiological and toxicological properties of this analog have not been evaluated. This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:-
  • 2,3-Dichlorophenylpiperazine is an analog of 3-chlorophenylpiperazine, a psychoactive drug of abuse.{20497,21515,19874} The physiological and toxicological properties of this analog have not been evaluated. This product is intended for forensic and research purposes.  

     

    Brand:
    Cayman
    SKU:-
  • 1,2,3-Thiadiazoles have diverse applications in medicine and agriculture, such as bactericides, fungicides, and antiviral agents. 2,3-dihydrothieno-Thiadiazole carboxylate (MTCC), 100 µM, both inhibits and inactivates certain microsomal CYP450 enzymes (CYP2E1 and CYP2B4), but not others (CYP1A2), with inactivation occurring in a mechanism-based manner.{15950}  

     

    Brand:
    Cayman
    SKU:10011048 - 10 mg

    Available on backorder

  • 1,2,3-Thiadiazoles have diverse applications in medicine and agriculture, such as bactericides, fungicides, and antiviral agents. 2,3-dihydrothieno-Thiadiazole carboxylate (MTCC), 100 µM, both inhibits and inactivates certain microsomal CYP450 enzymes (CYP2E1 and CYP2B4), but not others (CYP1A2), with inactivation occurring in a mechanism-based manner.{15950}  

     

    Brand:
    Cayman
    SKU:10011048 - 100 mg

    Available on backorder

  • 1,2,3-Thiadiazoles have diverse applications in medicine and agriculture, such as bactericides, fungicides, and antiviral agents. 2,3-dihydrothieno-Thiadiazole carboxylate (MTCC), 100 µM, both inhibits and inactivates certain microsomal CYP450 enzymes (CYP2E1 and CYP2B4), but not others (CYP1A2), with inactivation occurring in a mechanism-based manner.{15950}  

     

    Brand:
    Cayman
    SKU:10011048 - 50 mg

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  • 2,3-Dimethoxy-5-methyl-p-benzoquinone, also known as coenzyme Q0, is a key intermediate in the synthesis of coenzyme Q, coenzyme Q10, other ubiquinones, and vitamin E.{43190,43191} It inhibits the growth of SKOV-3, A2780, and A2870/CP70 human ovarian carcinoma cells (IC50s = 26.6, 27.3, and 28.4 µM, respectively) with a cytotoxic concentration of greater than 40 µM for non-cancerous ovarian surface epithelial cells.{43192} It halts the cell cycle at the G2/M phase, increases the production of reactive oxygen species (ROS), and induces autophagy and apoptosis in SKOV-3 cells. 2,3-Dimethoxy-5-methyl-p-benzoquinone downregulates the protooncogene HER-2 and decreases the protein levels of phosphorylated AKT and mTOR in SKOV-3 cells. It also decreases the incidence of tumors and tumor burden in a SKOV-3 human ovarian carcinoma mouse xenograft model when administered at a dose of 2.5 mg/kg every four days.  

     

    Brand:
    Cayman
    SKU:20504 -

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  • 2,3-Dimethoxy-5-methyl-p-benzoquinone, also known as coenzyme Q0, is a key intermediate in the synthesis of coenzyme Q, coenzyme Q10, other ubiquinones, and vitamin E.{43190,43191} It inhibits the growth of SKOV-3, A2780, and A2870/CP70 human ovarian carcinoma cells (IC50s = 26.6, 27.3, and 28.4 µM, respectively) with a cytotoxic concentration of greater than 40 µM for non-cancerous ovarian surface epithelial cells.{43192} It halts the cell cycle at the G2/M phase, increases the production of reactive oxygen species (ROS), and induces autophagy and apoptosis in SKOV-3 cells. 2,3-Dimethoxy-5-methyl-p-benzoquinone downregulates the protooncogene HER-2 and decreases the protein levels of phosphorylated AKT and mTOR in SKOV-3 cells. It also decreases the incidence of tumors and tumor burden in a SKOV-3 human ovarian carcinoma mouse xenograft model when administered at a dose of 2.5 mg/kg every four days.  

     

    Brand:
    Cayman
    SKU:20504 -

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  • 2,3-Dimethoxy-5-methyl-p-benzoquinone, also known as coenzyme Q0, is a key intermediate in the synthesis of coenzyme Q, coenzyme Q10, other ubiquinones, and vitamin E.{43190,43191} It inhibits the growth of SKOV-3, A2780, and A2870/CP70 human ovarian carcinoma cells (IC50s = 26.6, 27.3, and 28.4 µM, respectively) with a cytotoxic concentration of greater than 40 µM for non-cancerous ovarian surface epithelial cells.{43192} It halts the cell cycle at the G2/M phase, increases the production of reactive oxygen species (ROS), and induces autophagy and apoptosis in SKOV-3 cells. 2,3-Dimethoxy-5-methyl-p-benzoquinone downregulates the protooncogene HER-2 and decreases the protein levels of phosphorylated AKT and mTOR in SKOV-3 cells. It also decreases the incidence of tumors and tumor burden in a SKOV-3 human ovarian carcinoma mouse xenograft model when administered at a dose of 2.5 mg/kg every four days.  

     

    Brand:
    Cayman
    SKU:20504 -

    Available on backorder

  • 2,3-Dimethoxy-5-methyl-p-benzoquinone, also known as coenzyme Q0, is a key intermediate in the synthesis of coenzyme Q, coenzyme Q10, other ubiquinones, and vitamin E.{43190,43191} It inhibits the growth of SKOV-3, A2780, and A2870/CP70 human ovarian carcinoma cells (IC50s = 26.6, 27.3, and 28.4 µM, respectively) with a cytotoxic concentration of greater than 40 µM for non-cancerous ovarian surface epithelial cells.{43192} It halts the cell cycle at the G2/M phase, increases the production of reactive oxygen species (ROS), and induces autophagy and apoptosis in SKOV-3 cells. 2,3-Dimethoxy-5-methyl-p-benzoquinone downregulates the protooncogene HER-2 and decreases the protein levels of phosphorylated AKT and mTOR in SKOV-3 cells. It also decreases the incidence of tumors and tumor burden in a SKOV-3 human ovarian carcinoma mouse xenograft model when administered at a dose of 2.5 mg/kg every four days.  

     

    Brand:
    Cayman
    SKU:20504 -

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  • 2,3-Dimethylmethcathinone (hydrochloride) is a potential designer drug with combined features of amphetamines, cathinones, and phenethylamines. It is structurally related to 4-methylmethcathinone, (Item No. 10801), a psychoactive compound that has been identified in products sold as bath salts and plant food.{19498,19499,19497} The physiological and toxicological properties of this compound have not been elucidated. This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:11225 - 10 mg

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  • 2,3-Dimethylmethcathinone (hydrochloride) is a potential designer drug with combined features of amphetamines, cathinones, and phenethylamines. It is structurally related to 4-methylmethcathinone, (Item No. 10801), a psychoactive compound that has been identified in products sold as bath salts and plant food.{19498,19499,19497} The physiological and toxicological properties of this compound have not been elucidated. This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:11225 - 5 mg

    Available on backorder

  • 2,3-Dimethylmethcathinone (hydrochloride) is a potential designer drug with combined features of amphetamines, cathinones, and phenethylamines. It is structurally related to 4-methylmethcathinone, (Item No. 10801), a psychoactive compound that has been identified in products sold as bath salts and plant food.{19498,19499,19497} The physiological and toxicological properties of this compound have not been elucidated. This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:11225 - 50 mg

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  • Prostaglandin E1 (PGE1) is not a major naturally occurring prostaglandin, but it is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction and in neonatal cardiology.{22,3803} The metabolism of PGE1 is normally initiated by oxidation at C-15, resulting in 13,14-dihydro-15-keto PGE1 as the major metabolite. However, inhibition of this pathway or saturation by excess substrate could theoretically lead to enhanced production of 2,3-dinor metabolites, including 2,3-dinor PGE1. The biological activity of 2,3-dinor PGE1 has not been published. Cayman Chemical is a leading supplier of prostaglandins and their metabolites, and is currently the exclusive manufacturer of 2,3-dinor PGE1.  

     

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    Cayman
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  • Prostaglandin E1 (PGE1) is not a major naturally occurring prostaglandin, but it is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction and in neonatal cardiology.{22,3803} The metabolism of PGE1 is normally initiated by oxidation at C-15, resulting in 13,14-dihydro-15-keto PGE1 as the major metabolite. However, inhibition of this pathway or saturation by excess substrate could theoretically lead to enhanced production of 2,3-dinor metabolites, including 2,3-dinor PGE1. The biological activity of 2,3-dinor PGE1 has not been published. Cayman Chemical is a leading supplier of prostaglandins and their metabolites, and is currently the exclusive manufacturer of 2,3-dinor PGE1.  

     

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    Cayman
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  • Prostaglandin E1 (PGE1) is not a major naturally occurring prostaglandin, but it is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction and in neonatal cardiology.{22,3803} The metabolism of PGE1 is normally initiated by oxidation at C-15, resulting in 13,14-dihydro-15-keto PGE1 as the major metabolite. However, inhibition of this pathway or saturation by excess substrate could theoretically lead to enhanced production of 2,3-dinor metabolites, including 2,3-dinor PGE1. The biological activity of 2,3-dinor PGE1 has not been published. Cayman Chemical is a leading supplier of prostaglandins and their metabolites, and is currently the exclusive manufacturer of 2,3-dinor PGE1.  

     

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    Cayman
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  • Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.{1410} In rats and rabbits, 2,3-dinor TXB1 has been identified as another urinary metabolite of TXB2.{12600,12599} However in human urine, only trace amounts of 2,3-dinor TXB1 have been identified.{12600} In rats, 2,3-dinor TXB1 is excreted at a much higher rate than 2,3-dinor TXB2 (19.2 ± 4.9 ng/24 hr and 1.6 ± 0.3 ng/24 hr, respectively).{12600} Therefore, urinary 2,3-dinor TXB1 is a suitable marker of thromboxane biosynthesis in rats.  

     

    Brand:
    Cayman
    SKU:10006330 - 100 µg

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  • Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.{1410} In rats and rabbits, 2,3-dinor TXB1 has been identified as another urinary metabolite of TXB2.{12600,12599} However in human urine, only trace amounts of 2,3-dinor TXB1 have been identified.{12600} In rats, 2,3-dinor TXB1 is excreted at a much higher rate than 2,3-dinor TXB2 (19.2 ± 4.9 ng/24 hr and 1.6 ± 0.3 ng/24 hr, respectively).{12600} Therefore, urinary 2,3-dinor TXB1 is a suitable marker of thromboxane biosynthesis in rats.  

     

    Brand:
    Cayman
    SKU:10006330 - 25 µg

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  • Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.{1410} In rats and rabbits, 2,3-dinor TXB1 has been identified as another urinary metabolite of TXB2.{12600,12599} However in human urine, only trace amounts of 2,3-dinor TXB1 have been identified.{12600} In rats, 2,3-dinor TXB1 is excreted at a much higher rate than 2,3-dinor TXB2 (19.2 ± 4.9 ng/24 hr and 1.6 ± 0.3 ng/24 hr, respectively).{12600} Therefore, urinary 2,3-dinor TXB1 is a suitable marker of thromboxane biosynthesis in rats.  

     

    Brand:
    Cayman
    SKU:10006330 - 50 µg

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  • Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.{1410} 2,3-dinor TXB2 is an abundant urinary metabolite of TXB2 and can be used as a marker for in vivo TXA2 synthesis.{1410,629,717} In healthy male volunteers, the median excretion of 2,3-dinor TXB2 is 10.3 ng/hour (138 pg/mg creatine).{629}  

     

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    Cayman
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  • Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.{1410} 2,3-dinor TXB2 is an abundant urinary metabolite of TXB2 and can be used as a marker for in vivo TXA2 synthesis.{1410,629,717} In healthy male volunteers, the median excretion of 2,3-dinor TXB2 is 10.3 ng/hour (138 pg/mg creatine).{629}  

     

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    Cayman
    SKU:-

    Available on backorder

  • Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.{1410} 2,3-dinor TXB2 is an abundant urinary metabolite of TXB2 and can be used as a marker for in vivo TXA2 synthesis.{1410,629,717} In healthy male volunteers, the median excretion of 2,3-dinor TXB2 is 10.3 ng/hour (138 pg/mg creatine).{629}  

     

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    Cayman
    SKU:-

    Available on backorder

  • Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.{1410} 2,3-dinor TXB2 is an abundant urinary metabolite of TXB2 and can be used as a marker for in vivo TXA2 synthesis.{1410,629,717} In healthy male volunteers, the median excretion of 2,3-dinor TXB2 is 10.3 ng/hour (138 pg/mg creatine).{629}  

     

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    Cayman
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  • 2,3-dinor-11β-Prostaglandin F2α (2,3-dinor-11β-PGF2α) was recovered from the urine of both normal monkeys and humans when infused with radiolabeled PGD2, where it represented approximately 1% and 4% of the infused radiolabeled dose, respectively.{418} 2,3-dinor-11β-PGF2α has also been recovered from the urine of mastocytosis patients, where it is excreted in large amounts.{416} In human asthmatic patients, 2,3-dinor-11β-PGF2α represents about 40% (as determined by GC/MS) of the immunoreactive 11β-PGF2α when measured using Cayman’s 11β-PGF2α EIA Kit (Item No. 516521). The excretion rate for 2,3-dinor-11β-PGF2α is approximately 200-250 ng/24 hours in a normal adult.{7577}  

     

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    Cayman
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    Out of stock

  • 2,3-dinor-11β-Prostaglandin F2α (2,3-dinor-11β-PGF2α) was recovered from the urine of both normal monkeys and humans when infused with radiolabeled PGD2, where it represented approximately 1% and 4% of the infused radiolabeled dose, respectively.{418} 2,3-dinor-11β-PGF2α has also been recovered from the urine of mastocytosis patients, where it is excreted in large amounts.{416} In human asthmatic patients, 2,3-dinor-11β-PGF2α represents about 40% (as determined by GC/MS) of the immunoreactive 11β-PGF2α when measured using Cayman’s 11β-PGF2α EIA Kit (Item No. 516521). The excretion rate for 2,3-dinor-11β-PGF2α is approximately 200-250 ng/24 hours in a normal adult.{7577}  

     

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    Cayman
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    Out of stock

  • 2,3-dinor-11β-Prostaglandin F2α (2,3-dinor-11β-PGF2α) was recovered from the urine of both normal monkeys and humans when infused with radiolabeled PGD2, where it represented approximately 1% and 4% of the infused radiolabeled dose, respectively.{418} 2,3-dinor-11β-PGF2α has also been recovered from the urine of mastocytosis patients, where it is excreted in large amounts.{416} In human asthmatic patients, 2,3-dinor-11β-PGF2α represents about 40% (as determined by GC/MS) of the immunoreactive 11β-PGF2α when measured using Cayman’s 11β-PGF2α EIA Kit (Item No. 516521). The excretion rate for 2,3-dinor-11β-PGF2α is approximately 200-250 ng/24 hours in a normal adult.{7577}  

     

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    Cayman
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    Out of stock

  • 8-iso Prostaglandin F2α (8-iso PGF2α; 8-isoprostane) is a prostaglandin-like product of non-specific lipid peroxidation.{320} 2,3-dinor-8-iso PGF2α is a metabolite of 8-iso PGF2α in humans and rats.{6907} In these species, exogenously infused 8-iso PGF2α is converted to 2,3-dinor-8-iso PGF1α and (2,3-dinor-8-iso PGF2α.{6907,3026} Rat hepatocytes further metabolize 8-iso PGF2α to another β-oxidation product, 2,3,4,5-tetranor-8-iso PGF2α.{6907} 2,3-dinor-8-iso PGF2α is present in normal human urine at concentrations of 200-300 pg/ml.{6907} Its concentration is increased in conditions of oxidative injury (for example, smoking), and correlates well with that of the parent isoprostane, 8-iso PGF2α.{6907}  

     

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    Cayman
    SKU:-
  • 8-iso Prostaglandin F2α (8-iso PGF2α; 8-isoprostane) is a prostaglandin-like product of non-specific lipid peroxidation.{320} 2,3-dinor-8-iso PGF2α is a metabolite of 8-iso PGF2α in humans and rats.{6907} In these species, exogenously infused 8-iso PGF2α is converted to 2,3-dinor-8-iso PGF1α and (2,3-dinor-8-iso PGF2α.{6907,3026} Rat hepatocytes further metabolize 8-iso PGF2α to another β-oxidation product, 2,3,4,5-tetranor-8-iso PGF2α.{6907} 2,3-dinor-8-iso PGF2α is present in normal human urine at concentrations of 200-300 pg/ml.{6907} Its concentration is increased in conditions of oxidative injury (for example, smoking), and correlates well with that of the parent isoprostane, 8-iso PGF2α.{6907}  

     

    Brand:
    Cayman
    SKU:-
  • 8-iso Prostaglandin F2α (8-iso PGF2α; 8-isoprostane) is a prostaglandin-like product of non-specific lipid peroxidation.{320} 2,3-dinor-8-iso PGF2α is a metabolite of 8-iso PGF2α in humans and rats.{6907} In these species, exogenously infused 8-iso PGF2α is converted to 2,3-dinor-8-iso PGF1α and (2,3-dinor-8-iso PGF2α.{6907,3026} Rat hepatocytes further metabolize 8-iso PGF2α to another β-oxidation product, 2,3,4,5-tetranor-8-iso PGF2α.{6907} 2,3-dinor-8-iso PGF2α is present in normal human urine at concentrations of 200-300 pg/ml.{6907} Its concentration is increased in conditions of oxidative injury (for example, smoking), and correlates well with that of the parent isoprostane, 8-iso PGF2α.{6907}  

     

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    Cayman
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  • 2,3-Isopropylidene-D-ribonolactone is a building block.{46908} It has been used in the stereocontrolled synthesis of the carbohydrates 6-epi-trehazolin and 6-epi-trehalamine.  

     

    Brand:
    Cayman
    SKU:30479 - 1 g

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  • 2,3-Isopropylidene-D-ribonolactone is a building block.{46908} It has been used in the stereocontrolled synthesis of the carbohydrates 6-epi-trehazolin and 6-epi-trehalamine.  

     

    Brand:
    Cayman
    SKU:30479 - 500 mg

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  • 3,4-Methylenedioxyamphetamine (MDA) is psychedelic and entactogenic drug that is scheduled as a controlled substance in the United States.{21366} 2,3-MDA is a structural isomer of MDA which differs only in the placement of the methyledioxy group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.  

     

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    Cayman
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  • 3,4-Methylenedioxyamphetamine (MDA) is psychedelic and entactogenic drug that is scheduled as a controlled substance in the United States.{21366} 2,3-MDA is a structural isomer of MDA which differs only in the placement of the methyledioxy group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.  

     

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    Cayman
    SKU:-
  • 3,4-Methylenedioxyamphetamine (MDA) is psychedelic and entactogenic drug that is scheduled as a controlled substance in the United States.{21366} 2,3-MDA is a structural isomer of MDA which differs only in the placement of the methyledioxy group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.  

     

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    Cayman
    SKU:-
  • 2,3-MDMA is an aromatic positional isomer of 3,4-MDMA (ecstasy, Item No. 13971), a euphoric entactogen that is illegal in most countries and is regulated (Schedule I) in the United States.{22085,21236} While 2,3-MDMA exhibits a similar potency to 3,4-MDMA for inhibition of the noradrenalin transporter (IC50s = 6.2 and 6.6 μM, respectively), it is less potent than 3,4-MDMA for inhibition of the serotonin transporter (IC50s = 82 μM and 34.8 μM, respectively).{20483} This compound is intended for forensic and research purposes only.  

     

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    Cayman
    SKU:-
  • 2,3-MDMA is an aromatic positional isomer of 3,4-MDMA (ecstasy, Item No. 13971), a euphoric entactogen that is illegal in most countries and is regulated (Schedule I) in the United States.{22085,21236} While 2,3-MDMA exhibits a similar potency to 3,4-MDMA for inhibition of the noradrenalin transporter (IC50s = 6.2 and 6.6 μM, respectively), it is less potent than 3,4-MDMA for inhibition of the serotonin transporter (IC50s = 82 μM and 34.8 μM, respectively).{20483} This compound is intended for forensic and research purposes only.  

     

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    Cayman
    SKU:-
  • 2,3-MDMA is an aromatic positional isomer of 3,4-MDMA (ecstasy, Item No. 13971), a euphoric entactogen that is illegal in most countries and is regulated (Schedule I) in the United States.{22085,21236} While 2,3-MDMA exhibits a similar potency to 3,4-MDMA for inhibition of the noradrenalin transporter (IC50s = 6.2 and 6.6 μM, respectively), it is less potent than 3,4-MDMA for inhibition of the serotonin transporter (IC50s = 82 μM and 34.8 μM, respectively).{20483} This compound is intended for forensic and research purposes only.  

     

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    Cayman
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  • 2,3,3-Trimethylindolenine-5-sulfonic Acid is a water soluble, fluorescent near-infrared dye that can be conjugated to peptides, proteins, nucleic acids, RNA, DNA, carbohydrates, polymers, and small molecules via a sulfonyl substituent.{28772,28771}  

     

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    Cayman
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  • 2,3,3-Trimethylindolenine-5-sulfonic Acid is a water soluble, fluorescent near-infrared dye that can be conjugated to peptides, proteins, nucleic acids, RNA, DNA, carbohydrates, polymers, and small molecules via a sulfonyl substituent.{28772,28771}  

     

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    Cayman
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  • 2,3,3-Trimethylindolenine-5-sulfonic Acid is a water soluble, fluorescent near-infrared dye that can be conjugated to peptides, proteins, nucleic acids, RNA, DNA, carbohydrates, polymers, and small molecules via a sulfonyl substituent.{28772,28771}  

     

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    Cayman
    SKU:-

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  • 2,3,3-Trimethylindolenine-5-sulfonic Acid is a water soluble, fluorescent near-infrared dye that can be conjugated to peptides, proteins, nucleic acids, RNA, DNA, carbohydrates, polymers, and small molecules via a sulfonyl substituent.{28772,28771}  

     

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    Cayman
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  • 2,3,4-Tri-O-acetyl-β-D-glucuronide methyl ester is a synthetic intermediate in the synthesis of prodrug forms of the antitumor antibiotic daunomycin (daunorubicin; Item No. 14159).{55086}  

     

    Brand:
    Cayman
    SKU:30540 - 1 g

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  • 2,3,4-Tri-O-acetyl-β-D-glucuronide methyl ester is a synthetic intermediate in the synthesis of prodrug forms of the antitumor antibiotic daunomycin (daunorubicin; Item No. 14159).{55086}  

     

    Brand:
    Cayman
    SKU:30540 - 100 mg

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  • 2,3,4-Tri-O-acetyl-β-D-glucuronide methyl ester is a synthetic intermediate in the synthesis of prodrug forms of the antitumor antibiotic daunomycin (daunorubicin; Item No. 14159).{55086}  

     

    Brand:
    Cayman
    SKU:30540 - 250 mg

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  • 2,3,4-Tri-O-acetyl-β-D-glucuronide methyl ester is a synthetic intermediate in the synthesis of prodrug forms of the antitumor antibiotic daunomycin (daunorubicin; Item No. 14159).{55086}  

     

    Brand:
    Cayman
    SKU:30540 - 500 mg

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  • 2,3,4-Trimethoxyamphetamine (hydrochloride) (Item No. 26491) is an analytical reference standard categorized as an amphetamine. It has hallucinogenic properties.{46060,49066} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:26491 - 1 mg

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  • 2,3,4-Trimethoxyamphetamine (hydrochloride) (Item No. 26491) is an analytical reference standard categorized as an amphetamine. It has hallucinogenic properties.{46060,49066} This product is intended for research and forensic applications.  

     

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    Cayman
    SKU:26491 - 5 mg

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  • 2,3,4,5-Tetrachlorophenol is a metabolite of the insecticide γ-lindane.{53465} It is toxic to fathead minnows and rainbow trout (LC50s = 0.496 and 0.304 mg/L, respectively, in tank water).{53466}  

     

    Brand:
    Cayman
    SKU:29743 - 100 mg

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  • 2,3,4,5-Tetrachlorophenol is a metabolite of the insecticide γ-lindane.{53465} It is toxic to fathead minnows and rainbow trout (LC50s = 0.496 and 0.304 mg/L, respectively, in tank water).{53466}  

     

    Brand:
    Cayman
    SKU:29743 - 25 mg

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  • 2,3,4,5-Tetrachlorophenol is a metabolite of the insecticide γ-lindane.{53465} It is toxic to fathead minnows and rainbow trout (LC50s = 0.496 and 0.304 mg/L, respectively, in tank water).{53466}  

     

    Brand:
    Cayman
    SKU:29743 - 50 mg

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  • 2,3,4,6-Tetra-O-benzoyl-β-D-glucopyranose is a D-glucopyranose derivative that has been used in glucosylation reactions.{33825,33826,33827,33828}  

     

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    Cayman
    SKU:-

    Out of stock

  • 2,3,4,6-Tetra-O-benzoyl-β-D-glucopyranose is a D-glucopyranose derivative that has been used in glucosylation reactions.{33825,33826,33827,33828}  

     

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    Cayman
    SKU:-

    Out of stock

  • 2,3,4,6-Tetra-O-benzoyl-β-D-glucopyranose is a D-glucopyranose derivative that has been used in glucosylation reactions.{33825,33826,33827,33828}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • 2,3,5-Trimethoxyamphetamine (hydrochloride) (Item No. 25396) is an analytical reference standard categorized as an amphetamine. It has hallucinogenic, psychotomimetic, and stimulant properties.{46060,46061} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:25396 - 1 mg

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  • 2,3,5-Trimethoxyamphetamine (hydrochloride) (Item No. 25396) is an analytical reference standard categorized as an amphetamine. It has hallucinogenic, psychotomimetic, and stimulant properties.{46060,46061} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:25396 - 5 mg

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  • 2,3,5,6-Tetramethylpyrazine is an alkaloid that has been found in L. wallichii and has diverse biological activities.{54098,54099,54100} It reduces kainate-induced increases in production of reactive oxygen species (ROS) and cytotoxicity in primary rat hippocampal neurons when used at a concentration of 5 µM.{54098} 2,3,5,6-Tetramethylpyrazine (0.1 mM) induces vasodilation in precontracted isolated and endothelium-denuded rat tail artery strips and reduces blood pressure in anesthetized rats.{54099} It decreases infarct volume, caspase-3 activation, and hypoxia-inducible factor-1α (HIF-1α) levels in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 20 mg/kg.{54100}  

     

    Brand:
    Cayman
    SKU:30281 - 100 g

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  • 2,3,5,6-Tetramethylpyrazine is an alkaloid that has been found in L. wallichii and has diverse biological activities.{54098,54099,54100} It reduces kainate-induced increases in production of reactive oxygen species (ROS) and cytotoxicity in primary rat hippocampal neurons when used at a concentration of 5 µM.{54098} 2,3,5,6-Tetramethylpyrazine (0.1 mM) induces vasodilation in precontracted isolated and endothelium-denuded rat tail artery strips and reduces blood pressure in anesthetized rats.{54099} It decreases infarct volume, caspase-3 activation, and hypoxia-inducible factor-1α (HIF-1α) levels in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 20 mg/kg.{54100}  

     

    Brand:
    Cayman
    SKU:30281 - 25 g

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  • 2,3,5,6-Tetramethylpyrazine is an alkaloid that has been found in L. wallichii and has diverse biological activities.{54098,54099,54100} It reduces kainate-induced increases in production of reactive oxygen species (ROS) and cytotoxicity in primary rat hippocampal neurons when used at a concentration of 5 µM.{54098} 2,3,5,6-Tetramethylpyrazine (0.1 mM) induces vasodilation in precontracted isolated and endothelium-denuded rat tail artery strips and reduces blood pressure in anesthetized rats.{54099} It decreases infarct volume, caspase-3 activation, and hypoxia-inducible factor-1α (HIF-1α) levels in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 20 mg/kg.{54100}  

     

    Brand:
    Cayman
    SKU:30281 - 50 g

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  • 2,3,5,6-Tetramethylpyrazine is an alkaloid that has been found in L. wallichii and has diverse biological activities.{54098,54099,54100} It reduces kainate-induced increases in production of reactive oxygen species (ROS) and cytotoxicity in primary rat hippocampal neurons when used at a concentration of 5 µM.{54098} 2,3,5,6-Tetramethylpyrazine (0.1 mM) induces vasodilation in precontracted isolated and endothelium-denuded rat tail artery strips and reduces blood pressure in anesthetized rats.{54099} It decreases infarct volume, caspase-3 activation, and hypoxia-inducible factor-1α (HIF-1α) levels in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 20 mg/kg.{54100}  

     

    Brand:
    Cayman
    SKU:30281 - 500 g

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  • 2,3,6-Trimethoxyamphetamine (hydrochloride) (Item No. 26492) is an analytical reference standard categorized as an amphetamine.{46061} 2,3,6-Trimethoxyamphetamine has hallucinogenic properties.{23274,45177} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:26492 - 1 mg

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  • 2,3,6-Trimethoxyamphetamine (hydrochloride) (Item No. 26492) is an analytical reference standard categorized as an amphetamine.{46061} 2,3,6-Trimethoxyamphetamine has hallucinogenic properties.{23274,45177} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:26492 - 5 mg

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  • 2,4-Diacetylphloroglucinol is a non-nitrogen-containing compound produced by some isolates of P. fluorescens and is active against numerous plant pathogenic fungi, viruses, bacteria, and nematodes.{29713,29711} It has been used to increase crop yield by controlling plant root diseases.{29713,29711}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • 2,4-Diacetylphloroglucinol is a non-nitrogen-containing compound produced by some isolates of P. fluorescens and is active against numerous plant pathogenic fungi, viruses, bacteria, and nematodes.{29713,29711} It has been used to increase crop yield by controlling plant root diseases.{29713,29711}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • 2,4-Diacetylphloroglucinol is a non-nitrogen-containing compound produced by some isolates of P. fluorescens and is active against numerous plant pathogenic fungi, viruses, bacteria, and nematodes.{29713,29711} It has been used to increase crop yield by controlling plant root diseases.{29713,29711}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • 2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.{1910,1263,1387}  

     

    Brand:
    Cayman
    SKU:81260 - 1 g

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  • 2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.{1910,1263,1387}  

     

    Brand:
    Cayman
    SKU:81260 - 10 g

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  • 2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.{1910,1263,1387}  

     

    Brand:
    Cayman
    SKU:81260 - 25 g

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  • 2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.{1910,1263,1387}  

     

    Brand:
    Cayman
    SKU:81260 - 5 g

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  • 2,4-Dichlorobenzenesulfonyl chloride is a heterocyclic building block.{52643} It has been used in the synthesis of nicotinyl arylsulfonylhydrazides that have anticancer and antibacterial activities in vitro.  

     

    Brand:
    Cayman
    SKU:30450 - 1 g

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  • 2,4-Dichlorobenzenesulfonyl chloride is a heterocyclic building block.{52643} It has been used in the synthesis of nicotinyl arylsulfonylhydrazides that have anticancer and antibacterial activities in vitro.  

     

    Brand:
    Cayman
    SKU:30450 - 5 g

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  • 2,4-Dichlorophenoxy acetic acid is a synthetic auxin, a class of plant growth regulators, that is often used as a supplement in plant cell culture media. It is also an active ingredient in herbicides that controls root elongation and cell production by disrupting the actin cytoskeleton.{16947}  

     

    Brand:
    Cayman
    SKU:10190 - 100 mg

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  • 2,4-Dichlorophenoxy acetic acid is a synthetic auxin, a class of plant growth regulators, that is often used as a supplement in plant cell culture media. It is also an active ingredient in herbicides that controls root elongation and cell production by disrupting the actin cytoskeleton.{16947}  

     

    Brand:
    Cayman
    SKU:10190 - 50 mg

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  • 2,4-Dimethylthiazole-5-carboxylic acid is a highly functionalized and biased thiazole used for drug discovery. It is used as a heterocyclic building block to specifically modify lead compounds.  

     

    Brand:
    Cayman
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  • 2,4-Dimethylthiazole-5-carboxylic acid is a highly functionalized and biased thiazole used for drug discovery. It is used as a heterocyclic building block to specifically modify lead compounds.  

     

    Brand:
    Cayman
    SKU:-
  • 2,4-Dimethylthiazole-5-carboxylic acid is a highly functionalized and biased thiazole used for drug discovery. It is used as a heterocyclic building block to specifically modify lead compounds.  

     

    Brand:
    Cayman
    SKU:-
  • 2,4-Dimethylthiazole-5-carboxylic acid is a highly functionalized and biased thiazole used for drug discovery. It is used as a heterocyclic building block to specifically modify lead compounds.  

     

    Brand:
    Cayman
    SKU:-
  • 2,4-DMA (hydrochloride) (Item No. 19746) is an analytical reference standard that is classified as an amphetamine. It is a serotonin 5-HT2 receptor agonist with an apparent pA2 value of 5.6.{31587} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:19746 -

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  • 2,4-DMA (hydrochloride) (Item No. 19746) is an analytical reference standard that is classified as an amphetamine. It is a serotonin 5-HT2 receptor agonist with an apparent pA2 value of 5.6.{31587} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:19746 -

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  • The pro-angiogenic factor HIF-1α is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH).{8840} 2,4-DPD is a cell permeable, competitive inhibitor of HIF-PH. 2,4-DPD inhibits the hydroxylation of P564 by acting as a competitive inhibitor of the HIF-PH cofactor α-keto glutarate, with effective concentrations in the low µM range.{9005} 2,4-DPD is therefore expected to act as a pro-angiogenic compound, via the HIF-1α system.{9790,8799}  

     

    Brand:
    Cayman
    SKU:71200 - 10 mg

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  • The pro-angiogenic factor HIF-1α is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH).{8840} 2,4-DPD is a cell permeable, competitive inhibitor of HIF-PH. 2,4-DPD inhibits the hydroxylation of P564 by acting as a competitive inhibitor of the HIF-PH cofactor α-keto glutarate, with effective concentrations in the low µM range.{9005} 2,4-DPD is therefore expected to act as a pro-angiogenic compound, via the HIF-1α system.{9790,8799}  

     

    Brand:
    Cayman
    SKU:71200 - 100 mg

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  • The pro-angiogenic factor HIF-1α is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH).{8840} 2,4-DPD is a cell permeable, competitive inhibitor of HIF-PH. 2,4-DPD inhibits the hydroxylation of P564 by acting as a competitive inhibitor of the HIF-PH cofactor α-keto glutarate, with effective concentrations in the low µM range.{9005} 2,4-DPD is therefore expected to act as a pro-angiogenic compound, via the HIF-1α system.{9790,8799}  

     

    Brand:
    Cayman
    SKU:71200 - 25 mg

    Available on backorder

  • The pro-angiogenic factor HIF-1α is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH).{8840} 2,4-DPD is a cell permeable, competitive inhibitor of HIF-PH. 2,4-DPD inhibits the hydroxylation of P564 by acting as a competitive inhibitor of the HIF-PH cofactor α-keto glutarate, with effective concentrations in the low µM range.{9005} 2,4-DPD is therefore expected to act as a pro-angiogenic compound, via the HIF-1α system.{9790,8799}  

     

    Brand:
    Cayman
    SKU:71200 - 50 mg

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  • 2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes.{23685,23686} As a 2-OG mimic, it blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl).{23686,23688} 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations.{23695,20945,23687} Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC50 = 1.5 µM), 2,4-PDCA modulates hypoxia-inducible factor turnover, collagen synthesis, and plant cell wall formation.{23686,18511} It can inhibit zinc-dependent enzymes, like metallo-β-lactamase.{23684} 2,4-PDCA also affects and is translocated by organic anion transporters.{23689}  

     

    Brand:
    Cayman
    SKU:11138 - 1 g

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  • 2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes.{23685,23686} As a 2-OG mimic, it blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl).{23686,23688} 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations.{23695,20945,23687} Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC50 = 1.5 µM), 2,4-PDCA modulates hypoxia-inducible factor turnover, collagen synthesis, and plant cell wall formation.{23686,18511} It can inhibit zinc-dependent enzymes, like metallo-β-lactamase.{23684} 2,4-PDCA also affects and is translocated by organic anion transporters.{23689}  

     

    Brand:
    Cayman
    SKU:11138 - 5 g

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  • 2,5-Anhydro-D-mannitol is an antimetabolic fructose analogue that increases food intake in rats at doses of 50-800 mg/kg by inhibiting gluconeogenesis and glycogenolysis in the liver.{33711,33710}. It is phosphorylated in the liver, which decreases available ATP and signals eating behavior in rats through a vagal nerve mechanism.{33709,33712}  

     

    Brand:
    Cayman
    SKU:21673 -

    Out of stock

  • 2,5-Anhydro-D-mannitol is an antimetabolic fructose analogue that increases food intake in rats at doses of 50-800 mg/kg by inhibiting gluconeogenesis and glycogenolysis in the liver.{33711,33710}. It is phosphorylated in the liver, which decreases available ATP and signals eating behavior in rats through a vagal nerve mechanism.{33709,33712}  

     

    Brand:
    Cayman
    SKU:21673 -

    Out of stock

  • 2,5-Anhydro-D-mannitol is an antimetabolic fructose analogue that increases food intake in rats at doses of 50-800 mg/kg by inhibiting gluconeogenesis and glycogenolysis in the liver.{33711,33710}. It is phosphorylated in the liver, which decreases available ATP and signals eating behavior in rats through a vagal nerve mechanism.{33709,33712}  

     

    Brand:
    Cayman
    SKU:21673 -

    Out of stock

  • 2,5-Anhydro-D-mannitol is an antimetabolic fructose analogue that increases food intake in rats at doses of 50-800 mg/kg by inhibiting gluconeogenesis and glycogenolysis in the liver.{33711,33710}. It is phosphorylated in the liver, which decreases available ATP and signals eating behavior in rats through a vagal nerve mechanism.{33709,33712}  

     

    Brand:
    Cayman
    SKU:21673 -

    Out of stock

  • 2,5-Deoxyfructosazine is a pyrazine derivative that can be found in cured tobacco and is used as a flavoring agent in the food and tobacco industry.{30119,30120} Pyrazines, including 2,5-deoxyfructosazine, can be produced either by pyrolytic decomposition of natural compounds or by the reaction of sugars with alcoholic ammonia.{30120} 2,5-Deoxyfructosazine is also formed by the breakdown of D-glucosamine at neutral pH.{30123,30121} Like glucosamine, 2,5-deoxyfructosazine has DNA strand breakage activity and strongly inhibits IL-2 production by Jurkat cells stimulated with phytohemagglutinin (IC50 = ~1.25 mM).{30122,30121,30123}  

     

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    Cayman
    SKU:-

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  • 2,5-Deoxyfructosazine is a pyrazine derivative that can be found in cured tobacco and is used as a flavoring agent in the food and tobacco industry.{30119,30120} Pyrazines, including 2,5-deoxyfructosazine, can be produced either by pyrolytic decomposition of natural compounds or by the reaction of sugars with alcoholic ammonia.{30120} 2,5-Deoxyfructosazine is also formed by the breakdown of D-glucosamine at neutral pH.{30123,30121} Like glucosamine, 2,5-deoxyfructosazine has DNA strand breakage activity and strongly inhibits IL-2 production by Jurkat cells stimulated with phytohemagglutinin (IC50 = ~1.25 mM).{30122,30121,30123}  

     

    Brand:
    Cayman
    SKU:-

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  • 2,5-Deoxyfructosazine is a pyrazine derivative that can be found in cured tobacco and is used as a flavoring agent in the food and tobacco industry.{30119,30120} Pyrazines, including 2,5-deoxyfructosazine, can be produced either by pyrolytic decomposition of natural compounds or by the reaction of sugars with alcoholic ammonia.{30120} 2,5-Deoxyfructosazine is also formed by the breakdown of D-glucosamine at neutral pH.{30123,30121} Like glucosamine, 2,5-deoxyfructosazine has DNA strand breakage activity and strongly inhibits IL-2 production by Jurkat cells stimulated with phytohemagglutinin (IC50 = ~1.25 mM).{30122,30121,30123}  

     

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    Cayman
    SKU:-

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  • 2,5-Dihydroxybenzaldehyde is a building block.{46911,46912} It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activity.  

     

    Brand:
    Cayman
    SKU:30268 - 10 g

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  • 2,5-Dihydroxybenzaldehyde is a building block.{46911,46912} It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activity.  

     

    Brand:
    Cayman
    SKU:30268 - 25 g

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  • 2,5-Dihydroxybenzaldehyde is a building block.{46911,46912} It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activity.  

     

    Brand:
    Cayman
    SKU:30268 - 5 g

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  • 2,5-Dihydroxybenzaldehyde is a building block.{46911,46912} It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activity.  

     

    Brand:
    Cayman
    SKU:30268 - 50 g

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  • 2,5-Dihydroxycinnamic acid phenethyl ester is an inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 0.33 µM for inhibition of 5-LO product synthesis in polymorphonuclear leukocytes (PMNLs) stimulated with the sarcoendoplasmic reticulum calcium ATPase (SERCA) inhibitor thapsigargin (Item No. 10522).{50734} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC50 = 16.41 µM) in a cell-free assay. 2,5-Dihydroxycinnamic acid phenethyl ester selectively decreases viability of RCC4 and 786-O cells lacking the Von Hippel-Lindau (VHL) tumor suppressor gene (IC50s = 8 and 34.8 µM, respectively) over cells homozygously expressing VHL (IC50s = 99.6 and >100 µM, respectively). However, it also decreases viability of RCC10 VHL-/- and RCC10 VHL+/+ cells (IC50s = 5.04 and 0.96 µM, respectively). It increases the levels of pro-caspase-3a, LC3B-I, and LC3B-II in RCC4 VHL-/- cells in a concentration-dependent manner.  

     

    Brand:
    Cayman
    SKU:29736 - 1 mg

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  • 2,5-Dihydroxycinnamic acid phenethyl ester is an inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 0.33 µM for inhibition of 5-LO product synthesis in polymorphonuclear leukocytes (PMNLs) stimulated with the sarcoendoplasmic reticulum calcium ATPase (SERCA) inhibitor thapsigargin (Item No. 10522).{50734} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC50 = 16.41 µM) in a cell-free assay. 2,5-Dihydroxycinnamic acid phenethyl ester selectively decreases viability of RCC4 and 786-O cells lacking the Von Hippel-Lindau (VHL) tumor suppressor gene (IC50s = 8 and 34.8 µM, respectively) over cells homozygously expressing VHL (IC50s = 99.6 and >100 µM, respectively). However, it also decreases viability of RCC10 VHL-/- and RCC10 VHL+/+ cells (IC50s = 5.04 and 0.96 µM, respectively). It increases the levels of pro-caspase-3a, LC3B-I, and LC3B-II in RCC4 VHL-/- cells in a concentration-dependent manner.  

     

    Brand:
    Cayman
    SKU:29736 - 10 mg

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  • 2,5-Dihydroxycinnamic acid phenethyl ester is an inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 0.33 µM for inhibition of 5-LO product synthesis in polymorphonuclear leukocytes (PMNLs) stimulated with the sarcoendoplasmic reticulum calcium ATPase (SERCA) inhibitor thapsigargin (Item No. 10522).{50734} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC50 = 16.41 µM) in a cell-free assay. 2,5-Dihydroxycinnamic acid phenethyl ester selectively decreases viability of RCC4 and 786-O cells lacking the Von Hippel-Lindau (VHL) tumor suppressor gene (IC50s = 8 and 34.8 µM, respectively) over cells homozygously expressing VHL (IC50s = 99.6 and >100 µM, respectively). However, it also decreases viability of RCC10 VHL-/- and RCC10 VHL+/+ cells (IC50s = 5.04 and 0.96 µM, respectively). It increases the levels of pro-caspase-3a, LC3B-I, and LC3B-II in RCC4 VHL-/- cells in a concentration-dependent manner.  

     

    Brand:
    Cayman
    SKU:29736 - 25 mg

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  • 2,5-Dihydroxycinnamic acid phenethyl ester is an inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 0.33 µM for inhibition of 5-LO product synthesis in polymorphonuclear leukocytes (PMNLs) stimulated with the sarcoendoplasmic reticulum calcium ATPase (SERCA) inhibitor thapsigargin (Item No. 10522).{50734} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC50 = 16.41 µM) in a cell-free assay. 2,5-Dihydroxycinnamic acid phenethyl ester selectively decreases viability of RCC4 and 786-O cells lacking the Von Hippel-Lindau (VHL) tumor suppressor gene (IC50s = 8 and 34.8 µM, respectively) over cells homozygously expressing VHL (IC50s = 99.6 and >100 µM, respectively). However, it also decreases viability of RCC10 VHL-/- and RCC10 VHL+/+ cells (IC50s = 5.04 and 0.96 µM, respectively). It increases the levels of pro-caspase-3a, LC3B-I, and LC3B-II in RCC4 VHL-/- cells in a concentration-dependent manner.  

     

    Brand:
    Cayman
    SKU:29736 - 5 mg

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  • 2,5-Dimethoxyamphetamine (2,5-DMA) is one of many amphetamines which have appeared on the illicit drug market.{20771} Like 2,4,5-trimethoxyamphetamine and related compounds, 2,5-DMA is a serotonin 5-HT2 receptor agonist and has psychoactive properties.{20771} This product is intended for research and forensic applications.  

     

    Brand:
    Cayman
    SKU:-
  • 2,5-dimethyl Celecoxib is a derivative of celecoxib (Item No. 10008672) that does not inhibit COX-2 (IC50 = >100 µM).{45305} It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 µM) and reduces prostaglandin E2 (PGE2; Item No. 14010) production in HeLa, A549, and HCA-7 cells (IC50s = 0.64, 0.83, and 3.08 µM, respectively).{45306} It inhibits proliferation of drug-sensitive RPMI8226 and multidrug-resistant 8226/Dox40 multiple myeloma cells, as well as increases the rate of apoptosis when used at concentrations of 20 and 30 µM.{45307} 2,5-dimethyl Celecoxib reduces the expression of survivin, cyclin A, cyclin B, MEK1, and MEK2 in 8226/Dox40 cells. The antiproliferative effect of 2,5-dimethyl celecoxib is independent of mPGES-1 inhibition.{45306}  

     

    Brand:
    Cayman
    SKU:10008006 - 10 mg

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  • 2,5-dimethyl Celecoxib is a derivative of celecoxib (Item No. 10008672) that does not inhibit COX-2 (IC50 = >100 µM).{45305} It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 µM) and reduces prostaglandin E2 (PGE2; Item No. 14010) production in HeLa, A549, and HCA-7 cells (IC50s = 0.64, 0.83, and 3.08 µM, respectively).{45306} It inhibits proliferation of drug-sensitive RPMI8226 and multidrug-resistant 8226/Dox40 multiple myeloma cells, as well as increases the rate of apoptosis when used at concentrations of 20 and 30 µM.{45307} 2,5-dimethyl Celecoxib reduces the expression of survivin, cyclin A, cyclin B, MEK1, and MEK2 in 8226/Dox40 cells. The antiproliferative effect of 2,5-dimethyl celecoxib is independent of mPGES-1 inhibition.{45306}  

     

    Brand:
    Cayman
    SKU:10008006 - 25 mg

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  • 2,5-dimethyl Celecoxib is a derivative of celecoxib (Item No. 10008672) that does not inhibit COX-2 (IC50 = >100 µM).{45305} It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 µM) and reduces prostaglandin E2 (PGE2; Item No. 14010) production in HeLa, A549, and HCA-7 cells (IC50s = 0.64, 0.83, and 3.08 µM, respectively).{45306} It inhibits proliferation of drug-sensitive RPMI8226 and multidrug-resistant 8226/Dox40 multiple myeloma cells, as well as increases the rate of apoptosis when used at concentrations of 20 and 30 µM.{45307} 2,5-dimethyl Celecoxib reduces the expression of survivin, cyclin A, cyclin B, MEK1, and MEK2 in 8226/Dox40 cells. The antiproliferative effect of 2,5-dimethyl celecoxib is independent of mPGES-1 inhibition.{45306}  

     

    Brand:
    Cayman
    SKU:10008006 - 5 mg

    Available on backorder

  • 2,5-DMMA is a designer drug that combines the 2,5 disubstitution pattern of 2,5-dimethoxyphenethylamines with the backbone of methamphetamine. While the physiological and toxicological properties of this compound are poorly studied, the absence of an additional third substitution at either the three or four position on similar phenethylamines and amphetamines typically reduces effects on monoamine action.{22700,20772} This product is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:-
  • 2,5-DMMA is a designer drug that combines the 2,5 disubstitution pattern of 2,5-dimethoxyphenethylamines with the backbone of methamphetamine. While the physiological and toxicological properties of this compound are poorly studied, the absence of an additional third substitution at either the three or four position on similar phenethylamines and amphetamines typically reduces effects on monoamine action.{22700,20772} This product is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:-
  • 2,5-DMMA is a designer drug that combines the 2,5 disubstitution pattern of 2,5-dimethoxyphenethylamines with the backbone of methamphetamine. While the physiological and toxicological properties of this compound are poorly studied, the absence of an additional third substitution at either the three or four position on similar phenethylamines and amphetamines typically reduces effects on monoamine action.{22700,20772} This product is intended for forensic and research applications.  

     

    Brand:
    Cayman
    SKU:-
  • 2,6-Dibromoquinone-4-chloroimide is a colorimetric dye for the detection of phenolic compounds.{42551} It produces an indigo dye upon reacting with phenolic compounds at a pH of approximately 9.4. 2,6-Dibromoquinone-4-chloroimide has been used as a Gibbs reagent for the colorimetric detection of phenolic compounds. It has also been used in chromogenic reactions for the quantitative colorimetric detection of aflatoxins, causing colorless aflatoxins to become green with an absorption band at 673 nm.{42552}  

     

    Brand:
    Cayman
    SKU:21056 -

    Out of stock

  • 2,6-Dibromoquinone-4-chloroimide is a colorimetric dye for the detection of phenolic compounds.{42551} It produces an indigo dye upon reacting with phenolic compounds at a pH of approximately 9.4. 2,6-Dibromoquinone-4-chloroimide has been used as a Gibbs reagent for the colorimetric detection of phenolic compounds. It has also been used in chromogenic reactions for the quantitative colorimetric detection of aflatoxins, causing colorless aflatoxins to become green with an absorption band at 673 nm.{42552}  

     

    Brand:
    Cayman
    SKU:21056 -

    Out of stock

  • 2,6-Dibromoquinone-4-chloroimide is a colorimetric dye for the detection of phenolic compounds.{42551} It produces an indigo dye upon reacting with phenolic compounds at a pH of approximately 9.4. 2,6-Dibromoquinone-4-chloroimide has been used as a Gibbs reagent for the colorimetric detection of phenolic compounds. It has also been used in chromogenic reactions for the quantitative colorimetric detection of aflatoxins, causing colorless aflatoxins to become green with an absorption band at 673 nm.{42552}  

     

    Brand:
    Cayman
    SKU:21056 -

    Out of stock

  • 2,6-Dichloropurine-9-β-D-riboside is a building block.{52788,52789} It has been used in the synthesis of photoaffinity probes for nucleotide binding sites in proteins.  

     

    Brand:
    Cayman
    SKU:31405 - 100 mg

    Available on backorder

  • 2,6-Dichloropurine-9-β-D-riboside is a building block.{52788,52789} It has been used in the synthesis of photoaffinity probes for nucleotide binding sites in proteins.  

     

    Brand:
    Cayman
    SKU:31405 - 25 mg

    Available on backorder

  • 2,6-Dichloropurine-9-β-D-riboside is a building block.{52788,52789} It has been used in the synthesis of photoaffinity probes for nucleotide binding sites in proteins.  

     

    Brand:
    Cayman
    SKU:31405 - 50 mg

    Available on backorder

  • 2,6-Dichloropurine-9-β-D-riboside is a building block.{52788,52789} It has been used in the synthesis of photoaffinity probes for nucleotide binding sites in proteins.  

     

    Brand:
    Cayman
    SKU:31405 - 500 mg

    Available on backorder

  • DCFH (commonly known as dichlorofluorescin) is used as an indicator of peroxynitrite formation.{6533,5356} DCFH is supplied as the diacetate ester. Following enzymatic or base-catalyzed cleavage of the diacetate groups, it is readily oxidized to the highly fluorescent product dichlorofluorescein (DHF). Peroxynitrite is an efficient mediator of this oxidation and neither NO, superoxide, nor hydrogen peroxide alone appear to oxidize DCFH. Formation of DHF can be monitored by fluorescence spectroscopy using excitation and emission wavelengths of 502 and 523 nm, respectively, or by absorbance spectroscopy at 500 nm (ɛ = 59,500 M−1cm−1).{6533,5356}  

     

    Brand:
    Cayman
    SKU:85155 - 100 mg

    Available on backorder

  • DCFH (commonly known as dichlorofluorescin) is used as an indicator of peroxynitrite formation.{6533,5356} DCFH is supplied as the diacetate ester. Following enzymatic or base-catalyzed cleavage of the diacetate groups, it is readily oxidized to the highly fluorescent product dichlorofluorescein (DHF). Peroxynitrite is an efficient mediator of this oxidation and neither NO, superoxide, nor hydrogen peroxide alone appear to oxidize DCFH. Formation of DHF can be monitored by fluorescence spectroscopy using excitation and emission wavelengths of 502 and 523 nm, respectively, or by absorbance spectroscopy at 500 nm (ɛ = 59,500 M−1cm−1).{6533,5356}  

     

    Brand:
    Cayman
    SKU:85155 - 250 mg

    Available on backorder

  • DCFH (commonly known as dichlorofluorescin) is used as an indicator of peroxynitrite formation.{6533,5356} DCFH is supplied as the diacetate ester. Following enzymatic or base-catalyzed cleavage of the diacetate groups, it is readily oxidized to the highly fluorescent product dichlorofluorescein (DHF). Peroxynitrite is an efficient mediator of this oxidation and neither NO, superoxide, nor hydrogen peroxide alone appear to oxidize DCFH. Formation of DHF can be monitored by fluorescence spectroscopy using excitation and emission wavelengths of 502 and 523 nm, respectively, or by absorbance spectroscopy at 500 nm (ɛ = 59,500 M−1cm−1).{6533,5356}  

     

    Brand:
    Cayman
    SKU:85155 - 50 mg

    Available on backorder

  • DCFH (commonly known as dichlorofluorescin) is used as an indicator of peroxynitrite formation.{6533,5356} DCFH is supplied as the diacetate ester. Following enzymatic or base-catalyzed cleavage of the diacetate groups, it is readily oxidized to the highly fluorescent product dichlorofluorescein (DHF). Peroxynitrite is an efficient mediator of this oxidation and neither NO, superoxide, nor hydrogen peroxide alone appear to oxidize DCFH. Formation of DHF can be monitored by fluorescence spectroscopy using excitation and emission wavelengths of 502 and 523 nm, respectively, or by absorbance spectroscopy at 500 nm (ɛ = 59,500 M−1cm−1).{6533,5356}  

     

    Brand:
    Cayman
    SKU:85155 - 500 mg

    Available on backorder

  • 2,7-Dimethoxy-6-(1-acetoxyethyl)juglone is a naphthoquinone derivative originally isolated from the fungus H. toruloidea.{48174}  

     

    Brand:
    Cayman
    SKU:27267 - 1 mg

    Available on backorder

  • 2,7-Dimethoxy-6-(1-acetoxyethyl)juglone is a naphthoquinone derivative originally isolated from the fungus H. toruloidea.{48174}  

     

    Brand:
    Cayman
    SKU:27267 - 500 µg

    Available on backorder

  • 2’-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication (IC50 = 0.3 µM in Huh-7 human hepatoma cells) that is not cytotoxic at concentrations up to 100 µM.{39652} It is converted intracellularly to adenosine triphosphate, which inhibits the RNA-dependent RNA polymerase nonstructural protein 5B (NS5B). It also inhibits growth of L. guyanensis in vitro (EC50 = 3 µM) and eradicates it when used at a concentration of 10 µM.{39653}  

     

    Brand:
    Cayman
    SKU:23062 - 100 mg

    Available on backorder

  • 2’-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication (IC50 = 0.3 µM in Huh-7 human hepatoma cells) that is not cytotoxic at concentrations up to 100 µM.{39652} It is converted intracellularly to adenosine triphosphate, which inhibits the RNA-dependent RNA polymerase nonstructural protein 5B (NS5B). It also inhibits growth of L. guyanensis in vitro (EC50 = 3 µM) and eradicates it when used at a concentration of 10 µM.{39653}  

     

    Brand:
    Cayman
    SKU:23062 - 50 mg

    Available on backorder

  • 2′-C-Methylcytidine (2CMC) is a ribonucleoside with broad-spectrum antiviral activity.{37119} It reduces the number of viral plaques in BHK-21 cells infected with dengue type 2, reovirus type 1, West Nile, and yellow fever RNA viruses with EC50 values of 95, 26, 80, and 75 μM, respectively. 2CMC inhibits hepatitis C virus (HCV) replication (EC50 = 2.2 μM in a replicon assay) and protects MDBK cells from infection with bovine virus diarrhea virus (BVDV; EC50 = 2.2 μM) and human coronavirus (HCoV; EC50 = 90 μM). It also reduces infectious virus yield in BHK-21 cells infected with foot-and-mouth disease virus (FMDV; EC50 = 6.4 μM) and swine vesicular disease virus (SVDV; EC50 = 45.2 μM).{37120} In vivo, 2CMC reduces viral shedding to undetectable levels in a mouse model of persistent norovirus infection.{37121}  

     

    Brand:
    Cayman
    SKU:22887 - 10 mg

    Available on backorder

  • 2′-C-Methylcytidine (2CMC) is a ribonucleoside with broad-spectrum antiviral activity.{37119} It reduces the number of viral plaques in BHK-21 cells infected with dengue type 2, reovirus type 1, West Nile, and yellow fever RNA viruses with EC50 values of 95, 26, 80, and 75 μM, respectively. 2CMC inhibits hepatitis C virus (HCV) replication (EC50 = 2.2 μM in a replicon assay) and protects MDBK cells from infection with bovine virus diarrhea virus (BVDV; EC50 = 2.2 μM) and human coronavirus (HCoV; EC50 = 90 μM). It also reduces infectious virus yield in BHK-21 cells infected with foot-and-mouth disease virus (FMDV; EC50 = 6.4 μM) and swine vesicular disease virus (SVDV; EC50 = 45.2 μM).{37120} In vivo, 2CMC reduces viral shedding to undetectable levels in a mouse model of persistent norovirus infection.{37121}  

     

    Brand:
    Cayman
    SKU:22887 - 25 mg

    Available on backorder

  • 2′-C-Methylcytidine (2CMC) is a ribonucleoside with broad-spectrum antiviral activity.{37119} It reduces the number of viral plaques in BHK-21 cells infected with dengue type 2, reovirus type 1, West Nile, and yellow fever RNA viruses with EC50 values of 95, 26, 80, and 75 μM, respectively. 2CMC inhibits hepatitis C virus (HCV) replication (EC50 = 2.2 μM in a replicon assay) and protects MDBK cells from infection with bovine virus diarrhea virus (BVDV; EC50 = 2.2 μM) and human coronavirus (HCoV; EC50 = 90 μM). It also reduces infectious virus yield in BHK-21 cells infected with foot-and-mouth disease virus (FMDV; EC50 = 6.4 μM) and swine vesicular disease virus (SVDV; EC50 = 45.2 μM).{37120} In vivo, 2CMC reduces viral shedding to undetectable levels in a mouse model of persistent norovirus infection.{37121}  

     

    Brand:
    Cayman
    SKU:22887 - 5 mg

    Available on backorder

  • 2’-Deoxyadenosine-5′-monophosphate is a derivative of the nucleic acid, AMP, in which the hydroxyl group on the 2′ carbon of the pentose has been reduced to a hydrogen atom. It has been used in the synthesis of novel photoaffinity labels for incorporation into DNA and to study adenosine-based interactions during DNA synthesis and DNA damage.{26544,26542,26543}  

     

    Brand:
    Cayman
    SKU:-
  • 2’-Deoxyadenosine-5′-monophosphate is a derivative of the nucleic acid, AMP, in which the hydroxyl group on the 2′ carbon of the pentose has been reduced to a hydrogen atom. It has been used in the synthesis of novel photoaffinity labels for incorporation into DNA and to study adenosine-based interactions during DNA synthesis and DNA damage.{26544,26542,26543}  

     

    Brand:
    Cayman
    SKU:-
  • 2’-Deoxyadenosine-5′-monophosphate is a derivative of the nucleic acid, AMP, in which the hydroxyl group on the 2′ carbon of the pentose has been reduced to a hydrogen atom. It has been used in the synthesis of novel photoaffinity labels for incorporation into DNA and to study adenosine-based interactions during DNA synthesis and DNA damage.{26544,26542,26543}  

     

    Brand:
    Cayman
    SKU:-
  • 2’-Deoxycytidine is a deoxyribonucleoside comprised of a deoxyribose sugar and a cytosine base.{48688} It is phosphorylated by deoxycytidine kinase in the cytosol or thymidine kinase 2 (TK2) in mitochondria to form deoxycytidine monophosphate (dCMP; Item No. 29340).{48673,48672} Oral administration of 2’-deoxycytidine in combination with deoxythymidine delays disease onset and increases lifespan in a Tk2 H126N knock-in (Tk2-/-) mouse model of TK2 deficiency.{48673}  

     

    Brand:
    Cayman
    SKU:30125 - 1 g

    Available on backorder

  • 2’-Deoxycytidine is a deoxyribonucleoside comprised of a deoxyribose sugar and a cytosine base.{48688} It is phosphorylated by deoxycytidine kinase in the cytosol or thymidine kinase 2 (TK2) in mitochondria to form deoxycytidine monophosphate (dCMP; Item No. 29340).{48673,48672} Oral administration of 2’-deoxycytidine in combination with deoxythymidine delays disease onset and increases lifespan in a Tk2 H126N knock-in (Tk2-/-) mouse model of TK2 deficiency.{48673}  

     

    Brand:
    Cayman
    SKU:30125 - 5 g

    Available on backorder

  • 2’-Deoxycytidine 5’-diphosphate (dCDP) is a nucleotide diphosphate used in various biochemical research applications including studies of DNA synthesis.{38216,38217,38218} It is a substrate for various nucleoside diphosphate kinases to synthesize dCTP.{38215}  

     

    Brand:
    Cayman
    SKU:22982 - 10 mg

    Available on backorder

  • 2’-Deoxycytidine 5’-diphosphate (dCDP) is a nucleotide diphosphate used in various biochemical research applications including studies of DNA synthesis.{38216,38217,38218} It is a substrate for various nucleoside diphosphate kinases to synthesize dCTP.{38215}  

     

    Brand:
    Cayman
    SKU:22982 - 25 mg

    Available on backorder

  • 2’-Deoxycytidine 5’-diphosphate (dCDP) is a nucleotide diphosphate used in various biochemical research applications including studies of DNA synthesis.{38216,38217,38218} It is a substrate for various nucleoside diphosphate kinases to synthesize dCTP.{38215}  

     

    Brand:
    Cayman
    SKU:22982 - 5 mg

    Available on backorder

  • 2’-Deoxycytidine 5’-diphosphate (dCDP) is a nucleotide diphosphate used in various biochemical research applications including studies of DNA synthesis.{38216,38217,38218} It is a substrate for various nucleoside diphosphate kinases to synthesize dCTP.{38215}  

     

    Brand:
    Cayman
    SKU:22982 - 50 mg

    Available on backorder

  • 2’-Deoxycytidine-5’-monophosphate (dCMP) is a deoxyribonucleotide.{48688} It is formed via phosphorylation of deoxycytidine by deoxycytidine kinase in the cytosol or thymidine kinase 2 (TK2) in mitochondria.{48672,48673} It is further phosphorylated by UMP-CMP kinase to form dCDP (Item No. 22982) during nucleic acid synthesis.{48674} dCMP (700 mg/kg) decreases hydroxyurea-induced neuroepithelial cell necrosis in embryonic mouse spinal cord when administered to pregnant dams.{48675} Oral administration of dCMP in combination with dTMP increases lifespan in Tk2 H126N knock-in (Tk2-/-) mouse model of TK2 deficiency.{48673}  

     

    Brand:
    Cayman
    SKU:29340 - 1 g

    Available on backorder

  • 2’-Deoxycytidine-5’-monophosphate (dCMP) is a deoxyribonucleotide.{48688} It is formed via phosphorylation of deoxycytidine by deoxycytidine kinase in the cytosol or thymidine kinase 2 (TK2) in mitochondria.{48672,48673} It is further phosphorylated by UMP-CMP kinase to form dCDP (Item No. 22982) during nucleic acid synthesis.{48674} dCMP (700 mg/kg) decreases hydroxyurea-induced neuroepithelial cell necrosis in embryonic mouse spinal cord when administered to pregnant dams.{48675} Oral administration of dCMP in combination with dTMP increases lifespan in Tk2 H126N knock-in (Tk2-/-) mouse model of TK2 deficiency.{48673}  

     

    Brand:
    Cayman
    SKU:29340 - 250 mg

    Available on backorder

  • 2’-Deoxycytidine-5’-monophosphate (dCMP) is a deoxyribonucleotide.{48688} It is formed via phosphorylation of deoxycytidine by deoxycytidine kinase in the cytosol or thymidine kinase 2 (TK2) in mitochondria.{48672,48673} It is further phosphorylated by UMP-CMP kinase to form dCDP (Item No. 22982) during nucleic acid synthesis.{48674} dCMP (700 mg/kg) decreases hydroxyurea-induced neuroepithelial cell necrosis in embryonic mouse spinal cord when administered to pregnant dams.{48675} Oral administration of dCMP in combination with dTMP increases lifespan in Tk2 H126N knock-in (Tk2-/-) mouse model of TK2 deficiency.{48673}  

     

    Brand:
    Cayman
    SKU:29340 - 5 g

    Available on backorder

  • 2’-Deoxycytidine-5’-monophosphate (dCMP) is a deoxyribonucleotide.{48688} It is formed via phosphorylation of deoxycytidine by deoxycytidine kinase in the cytosol or thymidine kinase 2 (TK2) in mitochondria.{48672,48673} It is further phosphorylated by UMP-CMP kinase to form dCDP (Item No. 22982) during nucleic acid synthesis.{48674} dCMP (700 mg/kg) decreases hydroxyurea-induced neuroepithelial cell necrosis in embryonic mouse spinal cord when administered to pregnant dams.{48675} Oral administration of dCMP in combination with dTMP increases lifespan in Tk2 H126N knock-in (Tk2-/-) mouse model of TK2 deficiency.{48673}  

     

    Brand:
    Cayman
    SKU:29340 - 500 mg

    Available on backorder

  • 2′-Deoxyguanosine is a purine nucleoside with diverse biological activities.{53664,53663,53662,53665} It inhibits the clonogenic growth of HL-60 and K562 leukemia cells (IC50s = 80 and 100 µM, respectively).{53664} 2′-Deoxyguanosine inhibits the growth of MOLT-4 T cells and MGL-8 B cells by 99.8 and 68.3%, respectively, when used at a concentration of 50 µM.{53663} It increases the number of binucleated cells, a marker of inhibited cytokinesis, in A. sativum meristems.{53662} 2′-Deoxyguanosine (>1 µM) also induces relaxation of precontracted isolated bovine lingual artery.{53665}  

     

    Brand:
    Cayman
    SKU:9002864 - 1 g

    Available on backorder

  • 2′-Deoxyguanosine is a purine nucleoside with diverse biological activities.{53664,53663,53662,53665} It inhibits the clonogenic growth of HL-60 and K562 leukemia cells (IC50s = 80 and 100 µM, respectively).{53664} 2′-Deoxyguanosine inhibits the growth of MOLT-4 T cells and MGL-8 B cells by 99.8 and 68.3%, respectively, when used at a concentration of 50 µM.{53663} It increases the number of binucleated cells, a marker of inhibited cytokinesis, in A. sativum meristems.{53662} 2′-Deoxyguanosine (>1 µM) also induces relaxation of precontracted isolated bovine lingual artery.{53665}  

     

    Brand:
    Cayman
    SKU:9002864 - 10 g

    Available on backorder

  • 2′-Deoxyguanosine is a purine nucleoside with diverse biological activities.{53664,53663,53662,53665} It inhibits the clonogenic growth of HL-60 and K562 leukemia cells (IC50s = 80 and 100 µM, respectively).{53664} 2′-Deoxyguanosine inhibits the growth of MOLT-4 T cells and MGL-8 B cells by 99.8 and 68.3%, respectively, when used at a concentration of 50 µM.{53663} It increases the number of binucleated cells, a marker of inhibited cytokinesis, in A. sativum meristems.{53662} 2′-Deoxyguanosine (>1 µM) also induces relaxation of precontracted isolated bovine lingual artery.{53665}  

     

    Brand:
    Cayman
    SKU:9002864 - 5 g

    Available on backorder

  • 2′-Deoxyguanosine 5′-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. In addition, dGMP can be efficiently phosphorylated by the type I thymidylate kinase of the malarial agent P. falciparum.{26880,26883} In humans, deficiency of mitochondrial deoxyguanosine kinase, which synthesizes dGMP from ATP and deoxyguanosine, contributes to mitochondrial DNA depletion syndrome.{26882,26881}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • 2′-Deoxyguanosine 5′-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. In addition, dGMP can be efficiently phosphorylated by the type I thymidylate kinase of the malarial agent P. falciparum.{26880,26883} In humans, deficiency of mitochondrial deoxyguanosine kinase, which synthesizes dGMP from ATP and deoxyguanosine, contributes to mitochondrial DNA depletion syndrome.{26882,26881}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • 2′-Deoxyguanosine 5′-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. In addition, dGMP can be efficiently phosphorylated by the type I thymidylate kinase of the malarial agent P. falciparum.{26880,26883} In humans, deficiency of mitochondrial deoxyguanosine kinase, which synthesizes dGMP from ATP and deoxyguanosine, contributes to mitochondrial DNA depletion syndrome.{26882,26881}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • 2’-Deoxyinosine is the nucleoside form of hypoxanthine (Item No. 22254).{59200} It is a product of DNA damage that is formed from 2’-deoxyadenosine (Item No. 27315) by adenosine deaminase or reactive nitrogen species (RNS).{59200,59201} 2’-deoxyinosine (1 mM) enhances apoptosis induced by 5-fluorouracil (5-FU; Item No. 14416) in HT-29 and SW620 cancer cells.{59202} It also enhances 5-FU-induced tumor growth suppression in an SW620 mouse xenograft model when administered at a dose of 1.6 g/kg twice per day.  

     

    Brand:
    Cayman
    SKU:31507 - 1 g

    Available on backorder

  • 2’-Deoxyinosine is the nucleoside form of hypoxanthine (Item No. 22254).{59200} It is a product of DNA damage that is formed from 2’-deoxyadenosine (Item No. 27315) by adenosine deaminase or reactive nitrogen species (RNS).{59200,59201} 2’-deoxyinosine (1 mM) enhances apoptosis induced by 5-fluorouracil (5-FU; Item No. 14416) in HT-29 and SW620 cancer cells.{59202} It also enhances 5-FU-induced tumor growth suppression in an SW620 mouse xenograft model when administered at a dose of 1.6 g/kg twice per day.  

     

    Brand:
    Cayman
    SKU:31507 - 10 g

    Available on backorder

  • 2’-Deoxyinosine is the nucleoside form of hypoxanthine (Item No. 22254).{59200} It is a product of DNA damage that is formed from 2’-deoxyadenosine (Item No. 27315) by adenosine deaminase or reactive nitrogen species (RNS).{59200,59201} 2’-deoxyinosine (1 mM) enhances apoptosis induced by 5-fluorouracil (5-FU; Item No. 14416) in HT-29 and SW620 cancer cells.{59202} It also enhances 5-FU-induced tumor growth suppression in an SW620 mouse xenograft model when administered at a dose of 1.6 g/kg twice per day.  

     

    Brand:
    Cayman
    SKU:31507 - 5 g

    Available on backorder

  • 2′-MeCCPA is an adenosine A1 receptor agonist.{61045} It is selective for adenosine A1 over A2A and A3 receptors in radioligand binding assays (Kis = 1.8, 3,900 and 5,000 nM, respectively) and inhibits forskolin-induced activation of adenylyl cyclase in rat cortical membranes (IC50 = 13.1 nM). 2′-MeCCPA (2.5-5 mg/kg) increases tail flick latency in the hot plate test and inhibits formalin-induced late nocifensive behavior in rats.{61046}  

     

    Brand:
    Cayman
    SKU:30935 - 1 mg

    Available on backorder

  • 2′-MeCCPA is an adenosine A1 receptor agonist.{61045} It is selective for adenosine A1 over A2A and A3 receptors in radioligand binding assays (Kis = 1.8, 3,900 and 5,000 nM, respectively) and inhibits forskolin-induced activation of adenylyl cyclase in rat cortical membranes (IC50 = 13.1 nM). 2′-MeCCPA (2.5-5 mg/kg) increases tail flick latency in the hot plate test and inhibits formalin-induced late nocifensive behavior in rats.{61046}  

     

    Brand:
    Cayman
    SKU:30935 - 10 mg

    Available on backorder

  • 2′-MeCCPA is an adenosine A1 receptor agonist.{61045} It is selective for adenosine A1 over A2A and A3 receptors in radioligand binding assays (Kis = 1.8, 3,900 and 5,000 nM, respectively) and inhibits forskolin-induced activation of adenylyl cyclase in rat cortical membranes (IC50 = 13.1 nM). 2′-MeCCPA (2.5-5 mg/kg) increases tail flick latency in the hot plate test and inhibits formalin-induced late nocifensive behavior in rats.{61046}  

     

    Brand:
    Cayman
    SKU:30935 - 5 mg

    Available on backorder

  • 2′-O-Methyladenosine is an analog of adenosine used to prepare nucleoside derivatives as inhibitors of viral RNA translation and replication.{27606}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock

  • 2′-O-Methyladenosine is an analog of adenosine used to prepare nucleoside derivatives as inhibitors of viral RNA translation and replication.{27606}  

     

    Brand:
    Cayman
    SKU:-

    Out of stock