Cayman
Showing 4351–4500 of 45550 results
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2-fluoro Palmitic acid inhibits sphingosine biosynthesis and long-chain acyl-CoA synthetase with an IC50 value of 0.2 mM.{1613}
Brand:CaymanSKU:90380 - 50 mgAvailable on backorder
2-fluoro Palmitic acid methyl ester is a monofluorinated form of palmitic acid methyl ester (Item No. 10007358). It is an intermediate in the synthesis of 2-iodoaldehydes, monofluorinated fatty acids, and polyfluoro ketones.{41478,41479,16700} [Matreya, LLC. Catalog No. 1718]
Brand:CaymanSKU:24526 - 1 mgAvailable on backorder
2-fluoro Palmitic acid methyl ester is a monofluorinated form of palmitic acid methyl ester (Item No. 10007358). It is an intermediate in the synthesis of 2-iodoaldehydes, monofluorinated fatty acids, and polyfluoro ketones.{41478,41479,16700} [Matreya, LLC. Catalog No. 1718]
Brand:CaymanSKU:24526 - 10 mgAvailable on backorder
2-fluoro Palmitic acid methyl ester is a monofluorinated form of palmitic acid methyl ester (Item No. 10007358). It is an intermediate in the synthesis of 2-iodoaldehydes, monofluorinated fatty acids, and polyfluoro ketones.{41478,41479,16700} [Matreya, LLC. Catalog No. 1718]
Brand:CaymanSKU:24526 - 5 mgAvailable on backorder
2-fluoro Viminol (Item No. 27233) is an analytical reference standard that is structurally similar to known opioids. This product is intended for research and forensic applications.
Brand:CaymanSKU:27233 - 1 mgAvailable on backorder
2-fluoro Viminol (Item No. 27233) is an analytical reference standard that is structurally similar to known opioids. This product is intended for research and forensic applications.
Brand:CaymanSKU:27233 - 5 mgAvailable on backorder
2-Fluoro-4-iodo benzonitrile is a building block.{54069,54070} It has been used in the synthesis of L. infantum trypanothione reductase (Li-TryR) dimerization and oxidoreductase activity inhibitors.{54069} 2-Fluoro-4-iodo benzonitrile has also been used in the synthesis of transient receptor potential ankyrin 1 (TRPA1) antagonists.{54070}
Brand:CaymanSKU:30483 - 1 gAvailable on backorder
2-Fluoro-4-iodo benzonitrile is a building block.{54069,54070} It has been used in the synthesis of L. infantum trypanothione reductase (Li-TryR) dimerization and oxidoreductase activity inhibitors.{54069} 2-Fluoro-4-iodo benzonitrile has also been used in the synthesis of transient receptor potential ankyrin 1 (TRPA1) antagonists.{54070}
Brand:CaymanSKU:30483 - 250 mgAvailable on backorder
2-Fluoro-4-iodo benzonitrile is a building block.{54069,54070} It has been used in the synthesis of L. infantum trypanothione reductase (Li-TryR) dimerization and oxidoreductase activity inhibitors.{54069} 2-Fluoro-4-iodo benzonitrile has also been used in the synthesis of transient receptor potential ankyrin 1 (TRPA1) antagonists.{54070}
Brand:CaymanSKU:30483 - 500 mgAvailable on backorder
2-Fluoroadenine is a heterocyclic building block that has been used in the synthesis of heat shock protein 90 (Hsp90) inhibitors that have anticancer activity in vitro.{46971} It is also cytotoxic to CEM human leukemia cells with an IC50 value of 0.15 µM.{46972}
Brand:CaymanSKU:30421 - 1 gAvailable on backorder
2-Fluoroadenine is a heterocyclic building block that has been used in the synthesis of heat shock protein 90 (Hsp90) inhibitors that have anticancer activity in vitro.{46971} It is also cytotoxic to CEM human leukemia cells with an IC50 value of 0.15 µM.{46972}
Brand:CaymanSKU:30421 - 250 mgAvailable on backorder
2-Fluoroadenine is a heterocyclic building block that has been used in the synthesis of heat shock protein 90 (Hsp90) inhibitors that have anticancer activity in vitro.{46971} It is also cytotoxic to CEM human leukemia cells with an IC50 value of 0.15 µM.{46972}
Brand:CaymanSKU:30421 - 500 mgAvailable on backorder
Halogenated amphetamines, including 4-fluoroamphetamine (4-FA), are psychostimulatory designer drugs which inhibit the uptake of monoamine neurotransmitters.{20299,19913} 2-Fluoroamphetamine (2-FA) (hydrochloride) is a structural isomer of 4-FA, having the fluorine at the 2, rather than the 4, position. The physiological and toxicological properties of 2-FA are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:11419 - 10 mgAvailable on backorder
Halogenated amphetamines, including 4-fluoroamphetamine (4-FA), are psychostimulatory designer drugs which inhibit the uptake of monoamine neurotransmitters.{20299,19913} 2-Fluoroamphetamine (2-FA) (hydrochloride) is a structural isomer of 4-FA, having the fluorine at the 2, rather than the 4, position. The physiological and toxicological properties of 2-FA are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:11419 - 5 mgAvailable on backorder
Halogenated amphetamines, including 4-fluoroamphetamine (4-FA), are psychostimulatory designer drugs which inhibit the uptake of monoamine neurotransmitters.{20299,19913} 2-Fluoroamphetamine (2-FA) (hydrochloride) is a structural isomer of 4-FA, having the fluorine at the 2, rather than the 4, position. The physiological and toxicological properties of 2-FA are not known. This product is intended for research and forensic applications.
Brand:CaymanSKU:11419 - 50 mgAvailable on backorder
2-Fluoroethamphetamine (hydrochloride) (Item No. 25266) is an analytical reference standard categorized as an amphetamine. This product is intended for research and forensic applications.
Brand:CaymanSKU:25266 - 1 mgAvailable on backorder
2-Fluoroethamphetamine (hydrochloride) (Item No. 25266) is an analytical reference standard categorized as an amphetamine. This product is intended for research and forensic applications.
Brand:CaymanSKU:25266 - 5 mgAvailable on backorder
2-Fluoromethamphetamine (2-FMA) is a stimulant drug related to methamphetamine and 2-fluoroamphetamine.{19913} Through little is known of the pharmacological properties of fluoro methoxy substituted amphetamines, 2-FMA has been identified as a component of designer drugs sold as “legal high” replacements for restricted substances.{19913, 20338} The hydrochloride formulation of this compound is intended for use as a standard for the forensic analysis of samples that may contain 2-FMA.
Brand:CaymanSKU:11420 - 10 mgAvailable on backorder
2-Fluoromethamphetamine (2-FMA) is a stimulant drug related to methamphetamine and 2-fluoroamphetamine.{19913} Through little is known of the pharmacological properties of fluoro methoxy substituted amphetamines, 2-FMA has been identified as a component of designer drugs sold as “legal high” replacements for restricted substances.{19913, 20338} The hydrochloride formulation of this compound is intended for use as a standard for the forensic analysis of samples that may contain 2-FMA.
Brand:CaymanSKU:11420 - 5 mgAvailable on backorder
2-Fluoromethamphetamine (2-FMA) is a stimulant drug related to methamphetamine and 2-fluoroamphetamine.{19913} Through little is known of the pharmacological properties of fluoro methoxy substituted amphetamines, 2-FMA has been identified as a component of designer drugs sold as “legal high” replacements for restricted substances.{19913, 20338} The hydrochloride formulation of this compound is intended for use as a standard for the forensic analysis of samples that may contain 2-FMA.
Brand:CaymanSKU:11420 - 50 mgAvailable on backorder
2-Fluorophenyl cyclopentyl ketone (Item No. 31035) is an analytical reference standard categorized as a precursor in the synthesis of fluoroketamine.{52551} This product is intended for research and forensic applications.
Brand:CaymanSKU:31035 - 1 mgAvailable on backorder
2-Fluorophenyl cyclopentyl ketone (Item No. 31035) is an analytical reference standard categorized as a precursor in the synthesis of fluoroketamine.{52551} This product is intended for research and forensic applications.
Brand:CaymanSKU:31035 - 5 mgAvailable on backorder
Enkephalin convertase, also known as carboxypeptidase E, removes C-terminal residues during the processing of propeptides, including enkephalin and proinsulin. 2-Guanidinoethylmercaptosuccinic acid (GEMSA) is a potent inhibitor of enkephalin convertase (Ki = 8.8 nM) that is functional in vivo.{30847,30845} It is a peptidomimetic inhibitor, occupying the specificity pocket of the enzyme.{30843} GEMSA can also inhibit other carboxypeptidases, including thrombin-activatable fibrinolysis inhibitor.{30844,30846}
Brand:CaymanSKU:-Available on backorder
Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress.{17702} Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1.{16386} Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents.{20661} 2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway. As a double Michael reaction acceptor, 2-HBA can directly modify cysteine sulfhydryl groups in Keap1 and consequently suppress Nrf2 ubiquitination, which leads to enhanced expression of antioxidative and cytoprotective enzymes.{21471} 2-HBA doubles the specific activity of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) in Hepa1c1c7 cells at 0.15 μM.{21472} In rapidly dividing mouse leukemia L1210 cells, 0.6 μM 2-HBA increases the activities of NQO1, glutathione reductase, and the levels of total glutathione.{21472,21473} At 5-15 μM, 2-HBA causes G2/M cell cycle arrest and p53-independent, caspase 3-mediated apoptosis.{21472}
Brand:CaymanSKU:11879 - 10 mgAvailable on backorder
Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress.{17702} Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1.{16386} Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents.{20661} 2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway. As a double Michael reaction acceptor, 2-HBA can directly modify cysteine sulfhydryl groups in Keap1 and consequently suppress Nrf2 ubiquitination, which leads to enhanced expression of antioxidative and cytoprotective enzymes.{21471} 2-HBA doubles the specific activity of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) in Hepa1c1c7 cells at 0.15 μM.{21472} In rapidly dividing mouse leukemia L1210 cells, 0.6 μM 2-HBA increases the activities of NQO1, glutathione reductase, and the levels of total glutathione.{21472,21473} At 5-15 μM, 2-HBA causes G2/M cell cycle arrest and p53-independent, caspase 3-mediated apoptosis.{21472}
Brand:CaymanSKU:11879 - 5 mgAvailable on backorder
Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress.{17702} Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1.{16386} Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents.{20661} 2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway. As a double Michael reaction acceptor, 2-HBA can directly modify cysteine sulfhydryl groups in Keap1 and consequently suppress Nrf2 ubiquitination, which leads to enhanced expression of antioxidative and cytoprotective enzymes.{21471} 2-HBA doubles the specific activity of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) in Hepa1c1c7 cells at 0.15 μM.{21472} In rapidly dividing mouse leukemia L1210 cells, 0.6 μM 2-HBA increases the activities of NQO1, glutathione reductase, and the levels of total glutathione.{21472,21473} At 5-15 μM, 2-HBA causes G2/M cell cycle arrest and p53-independent, caspase 3-mediated apoptosis.{21472}
Brand:CaymanSKU:11879 - 50 mgAvailable on backorder
2-heptyl-3-hydroxy-4(1H)-Quinolone is a quorum-sensing signaling molecule produced by P. aeruginosa in response to increasing cell density.{45615} It increases expression of the lasB gene, which encodes the virulence factor elastase, in P. aeruginosa (EC50 = ~30 µM in a reporter cell assay). 2-heptyl-3-hydroxy-4(1H)-Quinolone (60 µM) increases secretion of the metabolite pyocyanin (Item No. 10009594) and the lectin PA-IL, as well as increases biofilm production in P. aeruginosa populations.{45616} It also reduces iron levels in P. aeruginosa growth media when used at a concentration of 40 µM and acts as an iron chelator in a Fe(III)-sulfate solution.{45617}
Brand:CaymanSKU:29186 - 10 mgAvailable on backorder
2-heptyl-3-hydroxy-4(1H)-Quinolone is a quorum-sensing signaling molecule produced by P. aeruginosa in response to increasing cell density.{45615} It increases expression of the lasB gene, which encodes the virulence factor elastase, in P. aeruginosa (EC50 = ~30 µM in a reporter cell assay). 2-heptyl-3-hydroxy-4(1H)-Quinolone (60 µM) increases secretion of the metabolite pyocyanin (Item No. 10009594) and the lectin PA-IL, as well as increases biofilm production in P. aeruginosa populations.{45616} It also reduces iron levels in P. aeruginosa growth media when used at a concentration of 40 µM and acts as an iron chelator in a Fe(III)-sulfate solution.{45617}
Brand:CaymanSKU:29186 - 5 mgAvailable on backorder
2-hexyl-4-Pentynoic acid is a derivative of valproic acid (Item No. 13033), an inhibitor of histone deacetylases (HDACs). It inhibits HDAC activity more potently (IC50 = 13 µM) than valproic acid (IC50 = 398 µM).{24558} 2-hexyl-4-Pentynoic acid induces histone hyperacetylation in cerebellar granule cells significantly at 5 µM.{24558} It also induces the expression of heat shock proteins Hsp70-1a and Hsp70-1b and protects cerebellar granule cells from glutamate-induced excitotoxicity when used at a concentration of 50 µM.{24558}
Brand:CaymanSKU:- 2-hexyl-4-Pentynoic acid is a derivative of valproic acid (Item No. 13033), an inhibitor of histone deacetylases (HDACs). It inhibits HDAC activity more potently (IC50 = 13 µM) than valproic acid (IC50 = 398 µM).{24558} 2-hexyl-4-Pentynoic acid induces histone hyperacetylation in cerebellar granule cells significantly at 5 µM.{24558} It also induces the expression of heat shock proteins Hsp70-1a and Hsp70-1b and protects cerebellar granule cells from glutamate-induced excitotoxicity when used at a concentration of 50 µM.{24558}
Brand:CaymanSKU:- 2-hexyl-4-Pentynoic acid is a derivative of valproic acid (Item No. 13033), an inhibitor of histone deacetylases (HDACs). It inhibits HDAC activity more potently (IC50 = 13 µM) than valproic acid (IC50 = 398 µM).{24558} 2-hexyl-4-Pentynoic acid induces histone hyperacetylation in cerebellar granule cells significantly at 5 µM.{24558} It also induces the expression of heat shock proteins Hsp70-1a and Hsp70-1b and protects cerebellar granule cells from glutamate-induced excitotoxicity when used at a concentration of 50 µM.{24558}
Brand:CaymanSKU:- 2-hexyl-4-Pentynoic acid is a derivative of valproic acid (Item No. 13033), an inhibitor of histone deacetylases (HDACs). It inhibits HDAC activity more potently (IC50 = 13 µM) than valproic acid (IC50 = 398 µM).{24558} 2-hexyl-4-Pentynoic acid induces histone hyperacetylation in cerebellar granule cells significantly at 5 µM.{24558} It also induces the expression of heat shock proteins Hsp70-1a and Hsp70-1b and protects cerebellar granule cells from glutamate-induced excitotoxicity when used at a concentration of 50 µM.{24558}
Brand:CaymanSKU:-
2-HOBA is an isoketal scavenger.{40882} In vivo, 2-HOBA reduces angiotensin II-induced increases in blood pressure and decreases isoketal accumulation in mouse heart and vasculature. It also prevents angiotensin II-induced collagen IV accumulation and renal damage in mouse kidney. 2-HOBA has also been used as a building block in the synthesis of saluretic agents and task-specific ionic liquids.{43249,43250}
Brand:CaymanSKU:25357 - 1 gAvailable on backorder
2-HOBA is an isoketal scavenger.{40882} In vivo, 2-HOBA reduces angiotensin II-induced increases in blood pressure and decreases isoketal accumulation in mouse heart and vasculature. It also prevents angiotensin II-induced collagen IV accumulation and renal damage in mouse kidney. 2-HOBA has also been used as a building block in the synthesis of saluretic agents and task-specific ionic liquids.{43249,43250}
Brand:CaymanSKU:25357 - 250 mgAvailable on backorder
2-HOBA is an isoketal scavenger.{40882} In vivo, 2-HOBA reduces angiotensin II-induced increases in blood pressure and decreases isoketal accumulation in mouse heart and vasculature. It also prevents angiotensin II-induced collagen IV accumulation and renal damage in mouse kidney. 2-HOBA has also been used as a building block in the synthesis of saluretic agents and task-specific ionic liquids.{43249,43250}
Brand:CaymanSKU:25357 - 5 gAvailable on backorder
2-HOBA is an isoketal scavenger.{40882} In vivo, 2-HOBA reduces angiotensin II-induced increases in blood pressure and decreases isoketal accumulation in mouse heart and vasculature. It also prevents angiotensin II-induced collagen IV accumulation and renal damage in mouse kidney. 2-HOBA has also been used as a building block in the synthesis of saluretic agents and task-specific ionic liquids.{43249,43250}
Brand:CaymanSKU:25357 - 500 mgAvailable on backorder
2-hydroxy Arachidic acid is a hydroxylated fatty acid that has been found in pasture grass (S. sphacelata) and soil from abandoned pastures in Ecuador, wool wax, and as the N-acyl chain of galactosylceramides in mouse brain.{41689,41690,39661} [Matreya, LLC. Catalog No. 1709]
Brand:CaymanSKU:24592 - 10 mgAvailable on backorder
2-hydroxy Arachidic acid is a hydroxylated fatty acid that has been found in pasture grass (S. sphacelata) and soil from abandoned pastures in Ecuador, wool wax, and as the N-acyl chain of galactosylceramides in mouse brain.{41689,41690,39661} [Matreya, LLC. Catalog No. 1709]
Brand:CaymanSKU:24592 - 25 mgAvailable on backorder
2-hydroxy Arachidic acid is a hydroxylated fatty acid that has been found in pasture grass (S. sphacelata) and soil from abandoned pastures in Ecuador, wool wax, and as the N-acyl chain of galactosylceramides in mouse brain.{41689,41690,39661} [Matreya, LLC. Catalog No. 1709]
Brand:CaymanSKU:24592 - 5 mgAvailable on backorder
2-hydroxy Arachidic acid methyl ester is a hydroxylated fatty acid methyl ester that has been found in sediment samples from the Harney River and in petroleum ether extracts of I. eriocarpa.{38856,38857} It is also a volatile flavoring compound in anhydrous milk fat (AMF) that is reduced by treatment with the lipases lipozyme-435 and TL-IM in a time-dependent manner.{38858} [Matreya, LLC. Catalog No. 1710]
Brand:CaymanSKU:24593 - 25 mgAvailable on backorder
2-hydroxy Atorvastatin is an active metabolite of the HMG-CoA reductase inhibitor atorvastatin (Item No. 10493).{57004} 2-hydroxy Atorvastatin is formed from atorvastatin by the cytochrome P450 (CYP) isoform CYP3A4. It inhibits lipid hydroperoxide formation and copper sulfate-induced thiobarbituric acid reactive substances (TBARS) formation in 1,2-dilinoleoyl-sn-glycero-3-PC (DLPC; Item No. 20954) vesicles and human LDL, respectively, in a concentration-dependent manner.{57005} 2-hydroxy Atorvastatin reduces cell death induced by oxygen-glucose deprivation (OGD) in primary rat cortical neurons and increases phosphorylation of cAMP-response-element-binding protein (CREB) in GABAergic neurons when used at a concentration of 600 nM following OGD.{57006}
Brand:CaymanSKU:30974 - 1 mgAvailable on backorder
2-hydroxy Decanoic acid is a fatty acid found in the lipophilic portion of the lipopolysaccharide fraction of P. ovalis, an aerobic bacterium.{39070} Synthesis of the hydroxy portion of 2-hydroxy decanoic acid occurs through oxygenation by monooxygenase, using molecular O2 as its substrate. [Matreya, LLC. Catalog No. 1758]
Brand:CaymanSKU:22678 -Out of stock
2-hydroxy Decanoic acid is a fatty acid found in the lipophilic portion of the lipopolysaccharide fraction of P. ovalis, an aerobic bacterium.{39070} Synthesis of the hydroxy portion of 2-hydroxy decanoic acid occurs through oxygenation by monooxygenase, using molecular O2 as its substrate. [Matreya, LLC. Catalog No. 1758]
Brand:CaymanSKU:22678 -Out of stock
2-hydroxy Decanoic acid is a fatty acid found in the lipophilic portion of the lipopolysaccharide fraction of P. ovalis, an aerobic bacterium.{39070} Synthesis of the hydroxy portion of 2-hydroxy decanoic acid occurs through oxygenation by monooxygenase, using molecular O2 as its substrate. [Matreya, LLC. Catalog No. 1758]
Brand:CaymanSKU:22678 -Out of stock
2-hydroxy Decanoic acid is a fatty acid found in the lipophilic portion of the lipopolysaccharide fraction of P. ovalis, an aerobic bacterium.{39070} Synthesis of the hydroxy portion of 2-hydroxy decanoic acid occurs through oxygenation by monooxygenase, using molecular O2 as its substrate. [Matreya, LLC. Catalog No. 1758]
Brand:CaymanSKU:22678 -Out of stock
2-hydroxy Decanoic acid methyl ester is a hydroxylated fatty acid methyl ester that has been found in A. precatorius extract and A. camphorata broth.{40837,40838} [Matreya, LLC. Catalog No. 1759]
Brand:CaymanSKU:24585 - 10 mgAvailable on backorder
2-hydroxy Decanoic acid methyl ester is a hydroxylated fatty acid methyl ester that has been found in A. precatorius extract and A. camphorata broth.{40837,40838} [Matreya, LLC. Catalog No. 1759]
Brand:CaymanSKU:24585 - 25 mgAvailable on backorder
2-hydroxy Decanoic acid methyl ester is a hydroxylated fatty acid methyl ester that has been found in A. precatorius extract and A. camphorata broth.{40837,40838} [Matreya, LLC. Catalog No. 1759]
Brand:CaymanSKU:24585 - 5 mgAvailable on backorder
2-hydroxy Decanoic acid methyl ester is a hydroxylated fatty acid methyl ester that has been found in A. precatorius extract and A. camphorata broth.{40837,40838} [Matreya, LLC. Catalog No. 1759]
Brand:CaymanSKU:24585 - 50 mgAvailable on backorder
2-hydroxy Docosanoic acid is a hydroxylated fatty acid that has been found in the mature black epidermis of the Antarctic minke whale, as the N-acyl chain of galactosylceramides in mouse brain, and the inner bark of E. globulus.{39660,39661,38892} It is upregulated in prostate carcinoma tissue as compared to normal prostate epithelium.{38044} [Matreya, LLC. Catalog No. 1711]
Brand:CaymanSKU:24594 - 25 mgAvailable on backorder
2-hydroxy Docosanoic acid methyl ester is a hydroxylated fatty acid methyl ester that has been found in ripe and unripe strawberry homogenates, Pseudosuberites and S. massa sea sponges, sediment samples from the Harney River, and C. frondosa and D. cinerea extracts.{38859,38860,38856,38861,38862} [Matreya, LLC. Catalog No. 1712]
Brand:CaymanSKU:24596 - 25 mgAvailable on backorder
2-hydroxy Flutamide is the major metabolite formed during the metabolism of the non-steroidal antiandrogen flutamide by cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4.{24727} Through competitive inhibition of the binding of testosterone to the nuclear androgen receptor (AR; IC50 = ~300-900), 2-hydroxy flutamide blocks the expression of AR target genes and prevents androgen-dependent stabilization of the AR.{24726} Compared to flutamide, 2-hydroxy flutamide is a more potent antiandrogen in vivo, demonstrating a higher binding affinity for the AR (0.1% binding affinity relative to dihydrotestosterone) and, thus, is the predominant contributor to the therapeutic effects of flutamide in the treatment of prostate cancer.{22432}
Brand:CaymanSKU:- 2-hydroxy Flutamide is the major metabolite formed during the metabolism of the non-steroidal antiandrogen flutamide by cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4.{24727} Through competitive inhibition of the binding of testosterone to the nuclear androgen receptor (AR; IC50 = ~300-900), 2-hydroxy flutamide blocks the expression of AR target genes and prevents androgen-dependent stabilization of the AR.{24726} Compared to flutamide, 2-hydroxy flutamide is a more potent antiandrogen in vivo, demonstrating a higher binding affinity for the AR (0.1% binding affinity relative to dihydrotestosterone) and, thus, is the predominant contributor to the therapeutic effects of flutamide in the treatment of prostate cancer.{22432}
Brand:CaymanSKU:- 2-hydroxy Flutamide is the major metabolite formed during the metabolism of the non-steroidal antiandrogen flutamide by cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4.{24727} Through competitive inhibition of the binding of testosterone to the nuclear androgen receptor (AR; IC50 = ~300-900), 2-hydroxy flutamide blocks the expression of AR target genes and prevents androgen-dependent stabilization of the AR.{24726} Compared to flutamide, 2-hydroxy flutamide is a more potent antiandrogen in vivo, demonstrating a higher binding affinity for the AR (0.1% binding affinity relative to dihydrotestosterone) and, thus, is the predominant contributor to the therapeutic effects of flutamide in the treatment of prostate cancer.{22432}
Brand:CaymanSKU:- 2-hydroxy Flutamide is the major metabolite formed during the metabolism of the non-steroidal antiandrogen flutamide by cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4.{24727} Through competitive inhibition of the binding of testosterone to the nuclear androgen receptor (AR; IC50 = ~300-900), 2-hydroxy flutamide blocks the expression of AR target genes and prevents androgen-dependent stabilization of the AR.{24726} Compared to flutamide, 2-hydroxy flutamide is a more potent antiandrogen in vivo, demonstrating a higher binding affinity for the AR (0.1% binding affinity relative to dihydrotestosterone) and, thus, is the predominant contributor to the therapeutic effects of flutamide in the treatment of prostate cancer.{22432}
Brand:CaymanSKU:-
2-hydroxy Lauric acid is a naturally occuring hydroxylated fatty acid that is found in Acinetobacter species.{36605} It acts as a partial agonist of free fatty acid receptor 1 (FFAR1/GPR40) and GPR84 receptors in vitro (EC50s = 6.7 and 12.8 μM, respectively).{40827} 2-hydroxy Lauric acid also inhibits bovine hepatic ligase (Ki = 4.4 μM) and mouse kidney mitochondrial medium-chain acyl-CoA synthetase by 48% at a concentration of 40 μM.{24586} [Matreya, LLC. Catalog No. 1701]
Brand:CaymanSKU:24586 - 10 mgAvailable on backorder
2-hydroxy Lauric acid is a naturally occuring hydroxylated fatty acid that is found in Acinetobacter species.{36605} It acts as a partial agonist of free fatty acid receptor 1 (FFAR1/GPR40) and GPR84 receptors in vitro (EC50s = 6.7 and 12.8 μM, respectively).{40827} 2-hydroxy Lauric acid also inhibits bovine hepatic ligase (Ki = 4.4 μM) and mouse kidney mitochondrial medium-chain acyl-CoA synthetase by 48% at a concentration of 40 μM.{24586} [Matreya, LLC. Catalog No. 1701]
Brand:CaymanSKU:24586 - 25 mgAvailable on backorder
2-hydroxy Lauric acid is a naturally occuring hydroxylated fatty acid that is found in Acinetobacter species.{36605} It acts as a partial agonist of free fatty acid receptor 1 (FFAR1/GPR40) and GPR84 receptors in vitro (EC50s = 6.7 and 12.8 μM, respectively).{40827} 2-hydroxy Lauric acid also inhibits bovine hepatic ligase (Ki = 4.4 μM) and mouse kidney mitochondrial medium-chain acyl-CoA synthetase by 48% at a concentration of 40 μM.{24586} [Matreya, LLC. Catalog No. 1701]
Brand:CaymanSKU:24586 - 50 mgAvailable on backorder
2-hydroxy Lauric acid methyl ester is a hydroxylated fatty acid methyl ester that has been found in coliform bacteria isolated from human sewage.{41524} [Matreya, LLC. Catalog No. 1702]
Brand:CaymanSKU:24587 - 25 mgAvailable on backorder
2-hydroxy Lauric acid methyl ester is a hydroxylated fatty acid methyl ester that has been found in coliform bacteria isolated from human sewage.{41524} [Matreya, LLC. Catalog No. 1702]
Brand:CaymanSKU:24587 - 50 mgAvailable on backorder
2-hydroxy Lignoceric acid is an α-hydroxy very long chain fatty acid that is normally present in the mammalian nervous system.{38043} In the brain, 2-hydroxy lignoceric acid is derived from lignoceric acid (Item No. 13353) and further converted to ceramides and cerebrosides during the process of nerve sheath myelination.{38043,17235,38045} 2-hydroxy Lignoceric acid is produced by the α-oxidation of lignoceric acid in the peroxisome and defects in this pathway are associated with disorders such as Zellweger syndrome.{17236,38044} [Matreya, LLC. Catalog No. 1715]
Brand:CaymanSKU:22680 -Out of stock
2-hydroxy Lignoceric acid methyl ester is a hydroxylated fatty acid methyl ester that has been found in ripe and unripe strawberry homogenates, Pseudosuberites and S. massa sea sponges, sediment samples from the Harney River and Lake Kivu, and the aerial parts of E. helioscopia.{38859,38860,38856,38863,38864} [Matreya, LLC. Catalog No. 1716]
Brand:CaymanSKU:24599 - 5 mgAvailable on backorder
2-hydroxy Myristic acid is a hydroxy fatty acid that has been found in bovine, human, and horse milk, cow and buffalo cheeses, sea bass filet, seal oil, human vernix caseosa, and wool wax.{41690} It inhibits cleavage between the enterovirus capsid proteins VP4 and VP2, a process required for enterovirus infectivity, as well as Junin and Tacaribe viral replication (IC50s = 20.1 and 14.2 μM, respectively).{46233,46234} 2-hydroxy Myristic acid was previously characterized as a weak inhibitor of peptide myristoylation (Ki = 200 μM) but has been shown to be inactive in ARL1 cells when used at 100 μM.{46235,43858} [Matreya, LLC. Catalog No. 1703]
Brand:CaymanSKU:90390 - 10 mgAvailable on backorder
2-hydroxy Myristic acid is a hydroxy fatty acid that has been found in bovine, human, and horse milk, cow and buffalo cheeses, sea bass filet, seal oil, human vernix caseosa, and wool wax.{41690} It inhibits cleavage between the enterovirus capsid proteins VP4 and VP2, a process required for enterovirus infectivity, as well as Junin and Tacaribe viral replication (IC50s = 20.1 and 14.2 μM, respectively).{46233,46234} 2-hydroxy Myristic acid was previously characterized as a weak inhibitor of peptide myristoylation (Ki = 200 μM) but has been shown to be inactive in ARL1 cells when used at 100 μM.{46235,43858} [Matreya, LLC. Catalog No. 1703]
Brand:CaymanSKU:90390 - 100 mgAvailable on backorder
2-hydroxy Myristic acid is a hydroxy fatty acid that has been found in bovine, human, and horse milk, cow and buffalo cheeses, sea bass filet, seal oil, human vernix caseosa, and wool wax.{41690} It inhibits cleavage between the enterovirus capsid proteins VP4 and VP2, a process required for enterovirus infectivity, as well as Junin and Tacaribe viral replication (IC50s = 20.1 and 14.2 μM, respectively).{46233,46234} 2-hydroxy Myristic acid was previously characterized as a weak inhibitor of peptide myristoylation (Ki = 200 μM) but has been shown to be inactive in ARL1 cells when used at 100 μM.{46235,43858} [Matreya, LLC. Catalog No. 1703]
Brand:CaymanSKU:90390 - 50 mgAvailable on backorder
2-hydroxy Myristic acid methyl ester is a rare hydroxylated fatty acid methyl ester that has been isolated from aquatic microbial sources.{38771} Levels of 2-hydroxy myristic acid methyl ester decrease to <1% in aquatic microbial communities after administration of the pesticide Atradex at a concentration of 245 mg/L.[Matreya, LLC. Catalog No. 1704]
Brand:CaymanSKU:24588 - 50 mgAvailable on backorder
2-hydroxy Palmitic acid is a form of the 16:0 long-chain saturated palmitic acid (Item No. 10006627).{39083} It is an intermediate in the metabolism of phytosphingosine to odd-numbered fatty acids.{39084} 2-hydroxy Palmitic acid levels in yeast fermentations increase following treatment with fumonisin B1 (Item No. 62580). [Matreya, LLC. Catalog No. 1705]
Brand:CaymanSKU:22679 -Out of stock
2-hydroxy Palmitic acid is a form of the 16:0 long-chain saturated palmitic acid (Item No. 10006627).{39083} It is an intermediate in the metabolism of phytosphingosine to odd-numbered fatty acids.{39084} 2-hydroxy Palmitic acid levels in yeast fermentations increase following treatment with fumonisin B1 (Item No. 62580). [Matreya, LLC. Catalog No. 1705]
Brand:CaymanSKU:22679 -Out of stock
2-hydroxy Palmitic acid is a form of the 16:0 long-chain saturated palmitic acid (Item No. 10006627).{39083} It is an intermediate in the metabolism of phytosphingosine to odd-numbered fatty acids.{39084} 2-hydroxy Palmitic acid levels in yeast fermentations increase following treatment with fumonisin B1 (Item No. 62580). [Matreya, LLC. Catalog No. 1705]
Brand:CaymanSKU:22679 -Out of stock
2-hydroxy Palmitic acid methyl ester is a naturally occuring hydroxy fatty acid methyl ester. It is a minor component in essential oils of P. sylvestris and B. javanica extracts which have larvicidal and cytotoxic activities, respectively.{39537,39538} [Matreya, LLC. Catalog No. 1706]
Brand:CaymanSKU:24589 - 50 mgAvailable on backorder
2-hydroxy Stearic acid is a naturally occurring hydroxylated fatty acid that has been found in humans and U. armoricana.{40839,40840,40841} It reduces growth of Ehrlich ascites tumor (EAT) cells in vitro when used at a concentration of 100 μM.{40842} Levels of 2-hydroxy stearic acid are elevated in human joint synovial fluid after ankle fracture and in patients with Buruli ulcer disease.{40840,40841} [Matreya, LLC. Catalog No. 1707]
Brand:CaymanSKU:24590 - 10 mgAvailable on backorder
2-hydroxy Stearic acid is a naturally occurring hydroxylated fatty acid that has been found in humans and U. armoricana.{40839,40840,40841} It reduces growth of Ehrlich ascites tumor (EAT) cells in vitro when used at a concentration of 100 μM.{40842} Levels of 2-hydroxy stearic acid are elevated in human joint synovial fluid after ankle fracture and in patients with Buruli ulcer disease.{40840,40841} [Matreya, LLC. Catalog No. 1707]
Brand:CaymanSKU:24590 - 25 mgAvailable on backorder
2-hydroxy Stearic acid is a naturally occurring hydroxylated fatty acid that has been found in humans and U. armoricana.{40839,40840,40841} It reduces growth of Ehrlich ascites tumor (EAT) cells in vitro when used at a concentration of 100 μM.{40842} Levels of 2-hydroxy stearic acid are elevated in human joint synovial fluid after ankle fracture and in patients with Buruli ulcer disease.{40840,40841} [Matreya, LLC. Catalog No. 1707]
Brand:CaymanSKU:24590 - 50 mgAvailable on backorder
2-hydroxy Stearic acid is a hydroxylated fatty acid methyl ester that broadens phase transition in dimyristoylphosphatidylcholine (DMPC) lipid membranes.{36607} It has been used in the synthesis of lipid-nucleotide conjugate anti-HIV agents to increase phosphodiester bond cleavage and the amount of liberated intracellular nucleotides.{36608} [Matreya, LLC. Catalog No. 1708]
Brand:CaymanSKU:24591 - 10 mgAvailable on backorder
2-hydroxy Stearic acid is a hydroxylated fatty acid methyl ester that broadens phase transition in dimyristoylphosphatidylcholine (DMPC) lipid membranes.{36607} It has been used in the synthesis of lipid-nucleotide conjugate anti-HIV agents to increase phosphodiester bond cleavage and the amount of liberated intracellular nucleotides.{36608} [Matreya, LLC. Catalog No. 1708]
Brand:CaymanSKU:24591 - 25 mgAvailable on backorder
2-hydroxy Stearic acid is a hydroxylated fatty acid methyl ester that broadens phase transition in dimyristoylphosphatidylcholine (DMPC) lipid membranes.{36607} It has been used in the synthesis of lipid-nucleotide conjugate anti-HIV agents to increase phosphodiester bond cleavage and the amount of liberated intracellular nucleotides.{36608} [Matreya, LLC. Catalog No. 1708]
Brand:CaymanSKU:24591 - 50 mgAvailable on backorder
2-hydroxy Tricosanoic acid is a hydroxylated fatty acid that has been found in the inner bark of E. globulus, the leaves of wild, kiyomi, and zweigeltrepe grape vines, C. elegans, and Pseudosuberites and S. massa sea sponges.{38892,38860,36609,36610} [Matreya, LLC. Catalog No. 1713]
Brand:CaymanSKU:24597 - 10 mgAvailable on backorder
2-hydroxy Tricosanoic acid methyl ester is a hydroxylated fatty acid methyl ester that has been found in ripe and unripe strawberry homogenates, Pseudosuberites and S. massa sea sponges, sediment samples from the Harney River, and the aerial parts of A. pilosa.{38859,38860,38856,41599} It inhibits protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase with IC50 values of 36.39 and 112.8 μM, respectively.{41599} [Matreya, LLC. Catalog No. 1714]
Brand:CaymanSKU:24598 - 1 mgAvailable on backorder
2-hydroxy Tricosanoic acid methyl ester is a hydroxylated fatty acid methyl ester that has been found in ripe and unripe strawberry homogenates, Pseudosuberites and S. massa sea sponges, sediment samples from the Harney River, and the aerial parts of A. pilosa.{38859,38860,38856,41599} It inhibits protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase with IC50 values of 36.39 and 112.8 μM, respectively.{41599} [Matreya, LLC. Catalog No. 1714]
Brand:CaymanSKU:24598 - 10 mgAvailable on backorder
2-hydroxy Tricosanoic acid methyl ester is a hydroxylated fatty acid methyl ester that has been found in ripe and unripe strawberry homogenates, Pseudosuberites and S. massa sea sponges, sediment samples from the Harney River, and the aerial parts of A. pilosa.{38859,38860,38856,41599} It inhibits protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase with IC50 values of 36.39 and 112.8 μM, respectively.{41599} [Matreya, LLC. Catalog No. 1714]
Brand:CaymanSKU:24598 - 5 mgAvailable on backorder
2-Hydroxy-4-methoxybenzaldehyde is a phenol found in the root bark essential oil of P. sepium that has diverse biological activities, including antibacterial, antifungal, fungicidal, antioxidant, anti-virulence, and metal chelating properties.{55018,55019,55020} It is active against Gram-positive (MICs = 100-200 µg/ml) and Gram-negative bacteria (MICs = 125-200 µg/ml), as well as the fungus C. albicans and the phytopathogenic fungus M. oryzae (MICs = 150 and 300 µg/ml, respectively). 2-Hydroxy-4-methoxybenzaldehyde scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals in a cell-free assay (IC50 = 9.04 mg/ml) and acts as a metal chelator, inhibiting ferrozine-Fe2+ complex formation with an IC50 value of 2.31 mg/ml. It reduces the production of the virulence factor staphyloxanthin in clinical isolates of methicillin-resistant S. aureus (MRSA) when used at a concentration of 200 µg/ml and decreases the expression of the MRSA virulence regulatory genes saeS, geh, crtM, and sigB.{55019} 2-Hydroxy-4-methoxybenzaldehyde, when used in combination with the antibiotics amikacin (Item No. 15405), gentamicin, cefotaxime (Item No. 16040), vancomycin (Item No. 15327), or tetracycline (Item No. 14328), increases MRSA antibiotic sensitivity. It is also an intermediate in the synthesis of Schiff base-metal complexes with antiproliferative activity.{55020}
Brand:CaymanSKU:30091 - 100 mgAvailable on backorder