Cayman
Showing 43801–43950 of 45550 results
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Vildagliptin-d7 has 7 deuteriums. Vildagliptin-d7 is intended for use as an internal standard for the quantification of vildagliptin (Item No. 14705) by GC- or LC-MS. Vildagliptin is an inhibitor of DPP-4 (IC50 = 3.5-34 nM).{24373,24372} It also inhibits DPP-8 and DPP-9 (Ki = 810 and 95 nM, respectively) but not DPP-2 or the related fibroblast activation protein α.{24377} Through its effects on DPP-4, it blocks the degradation of several circulating peptides, including incretins (stimulators of insulin secretion) like glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1.{24376,24378} Vildagliptin reduces fasting and postprandial glucose levels and decreases inflammatory and oxidative stress in diverse animal models of disease.{24375,24374}
Brand:CaymanSKU:22373 -Out of stock
Vildagliptin-d7 has 7 deuteriums. Vildagliptin-d7 is intended for use as an internal standard for the quantification of vildagliptin (Item No. 14705) by GC- or LC-MS. Vildagliptin is an inhibitor of DPP-4 (IC50 = 3.5-34 nM).{24373,24372} It also inhibits DPP-8 and DPP-9 (Ki = 810 and 95 nM, respectively) but not DPP-2 or the related fibroblast activation protein α.{24377} Through its effects on DPP-4, it blocks the degradation of several circulating peptides, including incretins (stimulators of insulin secretion) like glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1.{24376,24378} Vildagliptin reduces fasting and postprandial glucose levels and decreases inflammatory and oxidative stress in diverse animal models of disease.{24375,24374}
Brand:CaymanSKU:22373 -Out of stock
Immunogen: Recombinant human vimentin protein • Host: Mouse • Species Reactivity: (+) Human • Cross Reactivity: (+) Citrullinated vimentin • Applications: ELISA, IP, and WB
Brand:CaymanSKU:20197- 100 µgAvailable on backorder
Immunogen: Recombinant human vimentin protein • Host: Mouse • Species Reactivity: (+) Human • Cross Reactivity: (+) Citrullinated vimentin • Applications: ELISA, IP, and WB
Brand:CaymanSKU:20197- 100 µg Vimentin is a cytoskeleton intermediate filament protein present in cells of mesenchymal origin, including leukocytes, endothelial cells, and smooth muscle cells.{42183} Each vimentin monomer contains a central α-helix that facilitates formation of the coil-coil dimer required for vimentin filament assembly.{42184} Vimentin is attached to nuclei, endoplasmic reticulum, and mitochondria, and has a role in positioning organelles in the cytosol. It regulates glial morphology, facilitates motility and directional migration of fibroblasts, and is critical to mechanotransduction of shear stress and maintenance of vascular endothelial integrity.{42183} Vimentin controls transport of LDL-derived cholesterol from lysosomes to esterification sites.{42185} It is an aggresome component, forming a cage-like structure around aggregated, undegraded proteins at the microtubule organizing center.{42186} Vimentin is subject to citrullination under high calcium concentrations, which can occur during macrophage apoptosis, and citrullinated vimentin has been shown to have a role in the production of anti-citrullinated protein antibodies (ACPAs).{31883,31884} ACPAs against citrullinated proteins, such as vimentin, are considered to be highly specific markers for rheumatoid arthritis and other autoimmune diseases.{31883} Cayman’s Vimentin Monoclonal Antibody (Clone 12E4) can be used for ELISA, immunoprecipitation, and Western blot applications. The antibody recognizes vimentin at ~54 kDa from human samples.
Brand:CaymanSKU:20197 - 100 µgAvailable on backorder
Vimentin is a cytoskeleton intermediate filament protein present in cells of mesenchymal origin, including leukocytes, endothelial cells, and smooth muscle cells.{42183} Each vimentin monomer contains a central α-helix that facilitates formation of the coil-coil dimer required for vimentin filament assembly.{42184} Vimentin is attached to nuclei, endoplasmic reticulum, and mitochondria, and has a role in positioning organelles in the cytosol. It regulates glial morphology, facilitates motility and directional migration of fibroblasts, and is critical to mechanotransduction of shear stress and maintenance of vascular endothelial integrity.{42183} Vimentin controls transport of LDL-derived cholesterol from lysosomes to esterification sites.{42185} It is an aggresome component, forming a cage-like structure around aggregated, undegraded proteins at the microtubule organizing center.{42186} Vimentin is subject to citrullination under high calcium concentrations, which can occur during macrophage apoptosis, and citrullinated vimentin has been shown to have a role in the production of anti-citrullinated protein antibodies (ACPAs).{31883,31884} ACPAs against citrullinated proteins, such as vimentin, are considered to be highly specific markers for rheumatoid arthritis and other autoimmune diseases.{31883} Cayman’s Vimentin Polyclonal Antibody can be used for Western blot and ELISA applications. The antibody recognizes vimentin at ~54 kDa from human samples.
Brand:CaymanSKU:25341 - 500 µgAvailable on backorder
Immunogen: Full-length human recombinant vimentin protein • Host: Rabbit • Species Reactivity: (+) Human • Applications: ELISA and WB
Brand:CaymanSKU:25341- 500 µgAvailable on backorder
Immunogen: Full-length human recombinant vimentin protein • Host: Rabbit • Species Reactivity: (+) Human • Applications: ELISA and WB
Brand:CaymanSKU:25341- 500 µg
Vinblastine, derived from C. roseus, also known as V. rosea, a Madagascar periwinkle, is an antimicrotubule drug used to treat certain cancers, including Hodgkin’s lymphoma, non-small cell lung, breast, head and neck, and testicular cancer. Like its chemical analog vincristine, vinblastine binds tubulin, inhibiting the assembly of microtubules and causing M phase-specific cell cycle arrest by disrupting microtubule assembly and proper formation of the mitotic spindle. It has been shown to inhibit steady-state tubulin addition to microtubules with a Ki value of 0.18 μM, inhibit B16 melanoma cell proliferation with an IC50 value of 1 nM, and produce complete inhibition of L-cell proliferation at 40 nM.{21119} Vinblastine is reported to be an effective component of certain chemotherapy regimens, particularly when used with bleomycin and methotrexate in vinblastine, bleomycin, and methotrexate combination chemotherapy for Stage IA or IIA Hodgkin lymphomas.{21618}
Brand:CaymanSKU:11762 - 10 mgAvailable on backorder
Vinblastine, derived from C. roseus, also known as V. rosea, a Madagascar periwinkle, is an antimicrotubule drug used to treat certain cancers, including Hodgkin’s lymphoma, non-small cell lung, breast, head and neck, and testicular cancer. Like its chemical analog vincristine, vinblastine binds tubulin, inhibiting the assembly of microtubules and causing M phase-specific cell cycle arrest by disrupting microtubule assembly and proper formation of the mitotic spindle. It has been shown to inhibit steady-state tubulin addition to microtubules with a Ki value of 0.18 μM, inhibit B16 melanoma cell proliferation with an IC50 value of 1 nM, and produce complete inhibition of L-cell proliferation at 40 nM.{21119} Vinblastine is reported to be an effective component of certain chemotherapy regimens, particularly when used with bleomycin and methotrexate in vinblastine, bleomycin, and methotrexate combination chemotherapy for Stage IA or IIA Hodgkin lymphomas.{21618}
Brand:CaymanSKU:11762 - 25 mgAvailable on backorder
Vinblastine, derived from C. roseus, also known as V. rosea, a Madagascar periwinkle, is an antimicrotubule drug used to treat certain cancers, including Hodgkin’s lymphoma, non-small cell lung, breast, head and neck, and testicular cancer. Like its chemical analog vincristine, vinblastine binds tubulin, inhibiting the assembly of microtubules and causing M phase-specific cell cycle arrest by disrupting microtubule assembly and proper formation of the mitotic spindle. It has been shown to inhibit steady-state tubulin addition to microtubules with a Ki value of 0.18 μM, inhibit B16 melanoma cell proliferation with an IC50 value of 1 nM, and produce complete inhibition of L-cell proliferation at 40 nM.{21119} Vinblastine is reported to be an effective component of certain chemotherapy regimens, particularly when used with bleomycin and methotrexate in vinblastine, bleomycin, and methotrexate combination chemotherapy for Stage IA or IIA Hodgkin lymphomas.{21618}
Brand:CaymanSKU:11762 - 5 mgAvailable on backorder
Vinblastine, derived from C. roseus, also known as V. rosea, a Madagascar periwinkle, is an antimicrotubule drug used to treat certain cancers, including Hodgkin’s lymphoma, non-small cell lung, breast, head and neck, and testicular cancer. Like its chemical analog vincristine, vinblastine binds tubulin, inhibiting the assembly of microtubules and causing M phase-specific cell cycle arrest by disrupting microtubule assembly and proper formation of the mitotic spindle. It has been shown to inhibit steady-state tubulin addition to microtubules with a Ki value of 0.18 μM, inhibit B16 melanoma cell proliferation with an IC50 value of 1 nM, and produce complete inhibition of L-cell proliferation at 40 nM.{21119} Vinblastine is reported to be an effective component of certain chemotherapy regimens, particularly when used with bleomycin and methotrexate in vinblastine, bleomycin, and methotrexate combination chemotherapy for Stage IA or IIA Hodgkin lymphomas.{21618}
Brand:CaymanSKU:11762 - 50 mgAvailable on backorder
Vincamine is an indole alkaloid found in the leaves of V. minor and C. roseus that is used as a peripheral vasodilator to increase blood flow to the brain.{21128} Vincamine contracts excised human cerebrovascular smooth muscle in vitro with an EC50 value of 30 μM and has been explored as a pharmacotherapy to treat cerebral metabolic and vascular diseases.{21127,21129}
Brand:CaymanSKU:11763 - 1 gAvailable on backorder
Vincamine is an indole alkaloid found in the leaves of V. minor and C. roseus that is used as a peripheral vasodilator to increase blood flow to the brain.{21128} Vincamine contracts excised human cerebrovascular smooth muscle in vitro with an EC50 value of 30 μM and has been explored as a pharmacotherapy to treat cerebral metabolic and vascular diseases.{21127,21129}
Brand:CaymanSKU:11763 - 5 gAvailable on backorder
Vincamine is an indole alkaloid found in the leaves of V. minor and C. roseus that is used as a peripheral vasodilator to increase blood flow to the brain.{21128} Vincamine contracts excised human cerebrovascular smooth muscle in vitro with an EC50 value of 30 μM and has been explored as a pharmacotherapy to treat cerebral metabolic and vascular diseases.{21127,21129}
Brand:CaymanSKU:11763 - 500 mgAvailable on backorder
Vinclozolin is a dicarboximide fungicide. Metabolites of vinclozolin, M1 and M2 (Item No. 10007452) are effective antagonists of the androgen receptor in rats.{13216} Formulations containing vinclozolin have been used for control of diseases caused by B. cinerea, S. sclerotiorum, and Monilinia species in grapes, fruits, vegetables, ornamental plants, and turfgrass.{13372}
Brand:CaymanSKU:23939 - 100 mgAvailable on backorder
Vinclozolin is a dicarboximide fungicide. Metabolites of vinclozolin, M1 and M2 (Item No. 10007452) are effective antagonists of the androgen receptor in rats.{13216} Formulations containing vinclozolin have been used for control of diseases caused by B. cinerea, S. sclerotiorum, and Monilinia species in grapes, fruits, vegetables, ornamental plants, and turfgrass.{13372}
Brand:CaymanSKU:23939 - 25 mgAvailable on backorder
Vinclozolin is a dicarboximide fungicide. Metabolites of vinclozolin, M1 and M2 (Item No. 10007452) are effective antagonists of the androgen receptor in rats.{13216} Formulations containing vinclozolin have been used for control of diseases caused by B. cinerea, S. sclerotiorum, and Monilinia species in grapes, fruits, vegetables, ornamental plants, and turfgrass.{13372}
Brand:CaymanSKU:23939 - 50 mgAvailable on backorder
Vinclozolin is a dicarboximide fungicide widely used in Europe and the United States for control of diseases caused by B. cinerea, S. sclerotiorum, and Monilinia species in grapes, fruits, vegetables, ornamental plants, and turfgrass.{13372} Metabolites of vinclozolin, M1 and M2, are effective antagonists of the androgen receptor in rats exhibiting Ki values of 92 and 9.7 µM respectively.{13216} In fathead minnow, M1 and M2 failed to compete for high-affinity, low capacity testosterone binding sites in brain and ovary cytosolic fractions suggesting that they are not anti-androgens in this species.{13374}
Brand:CaymanSKU:10007452 - 10 mgAvailable on backorder
Vinclozolin is a dicarboximide fungicide widely used in Europe and the United States for control of diseases caused by B. cinerea, S. sclerotiorum, and Monilinia species in grapes, fruits, vegetables, ornamental plants, and turfgrass.{13372} Metabolites of vinclozolin, M1 and M2, are effective antagonists of the androgen receptor in rats exhibiting Ki values of 92 and 9.7 µM respectively.{13216} In fathead minnow, M1 and M2 failed to compete for high-affinity, low capacity testosterone binding sites in brain and ovary cytosolic fractions suggesting that they are not anti-androgens in this species.{13374}
Brand:CaymanSKU:10007452 - 25 mgAvailable on backorder
Vinclozolin is a dicarboximide fungicide widely used in Europe and the United States for control of diseases caused by B. cinerea, S. sclerotiorum, and Monilinia species in grapes, fruits, vegetables, ornamental plants, and turfgrass.{13372} Metabolites of vinclozolin, M1 and M2, are effective antagonists of the androgen receptor in rats exhibiting Ki values of 92 and 9.7 µM respectively.{13216} In fathead minnow, M1 and M2 failed to compete for high-affinity, low capacity testosterone binding sites in brain and ovary cytosolic fractions suggesting that they are not anti-androgens in this species.{13374}
Brand:CaymanSKU:10007452 - 5 mgAvailable on backorder
Vinclozolin is a dicarboximide fungicide widely used in Europe and the United States for control of diseases caused by B. cinerea, S. sclerotiorum, and Monilinia species in grapes, fruits, vegetables, ornamental plants, and turfgrass.{13372} Metabolites of vinclozolin, M1 and M2, are effective antagonists of the androgen receptor in rats exhibiting Ki values of 92 and 9.7 µM respectively.{13216} In fathead minnow, M1 and M2 failed to compete for high-affinity, low capacity testosterone binding sites in brain and ovary cytosolic fractions suggesting that they are not anti-androgens in this species.{13374}
Brand:CaymanSKU:10007452 - 50 mgAvailable on backorder
Vincristine is an antimitotic vinca alkaloid, isolated from the plant V. rosea. It irreversibly blocks mitosis by binding to tubulin (Ki = 85 nM) and inhibiting tubulin polymerization.{21119,21120} Vincristine is exported from cells via the ATP-binding cassette transporter P-glycoprotein, but not by multidrug resistance-associated protein.{21121} Its effectiveness in blocking the proliferation of cancer cells is affected by overexpression of P-glycoprotein.{21122}
Brand:CaymanSKU:11764 - 10 mgAvailable on backorder
Vincristine is an antimitotic vinca alkaloid, isolated from the plant V. rosea. It irreversibly blocks mitosis by binding to tubulin (Ki = 85 nM) and inhibiting tubulin polymerization.{21119,21120} Vincristine is exported from cells via the ATP-binding cassette transporter P-glycoprotein, but not by multidrug resistance-associated protein.{21121} Its effectiveness in blocking the proliferation of cancer cells is affected by overexpression of P-glycoprotein.{21122}
Brand:CaymanSKU:11764 - 25 mgAvailable on backorder
Vincristine is an antimitotic vinca alkaloid, isolated from the plant V. rosea. It irreversibly blocks mitosis by binding to tubulin (Ki = 85 nM) and inhibiting tubulin polymerization.{21119,21120} Vincristine is exported from cells via the ATP-binding cassette transporter P-glycoprotein, but not by multidrug resistance-associated protein.{21121} Its effectiveness in blocking the proliferation of cancer cells is affected by overexpression of P-glycoprotein.{21122}
Brand:CaymanSKU:11764 - 5 mgAvailable on backorder
Vindoline, a major alkaloid from the leaves of C. roseus, is a biologically active compound used as starting material for the synthesis of the anticancer antibiotics vinblastine and vincristine.{21132,21130,21131}
Brand:CaymanSKU:11765 - 10 mgAvailable on backorder
Vindoline, a major alkaloid from the leaves of C. roseus, is a biologically active compound used as starting material for the synthesis of the anticancer antibiotics vinblastine and vincristine.{21132,21130,21131}
Brand:CaymanSKU:11765 - 25 mgAvailable on backorder
Vindoline, a major alkaloid from the leaves of C. roseus, is a biologically active compound used as starting material for the synthesis of the anticancer antibiotics vinblastine and vincristine.{21132,21130,21131}
Brand:CaymanSKU:11765 - 5 mgAvailable on backorder
Vindoline, a major alkaloid from the leaves of C. roseus, is a biologically active compound used as starting material for the synthesis of the anticancer antibiotics vinblastine and vincristine.{21132,21130,21131}
Brand:CaymanSKU:11765 - 50 mgAvailable on backorder
Vinorelbine is a semi-synthetic vinca alkaloid with microtubule destabilizing activity.{24892,28232} It inhibits microtubule polymerization and blocks mitosis at the metaphase/anaphase transition, preventing HeLa cell proliferation with an IC50 value of 1.25 nM.{33560} In in vitro and in vivo models, vinorelbine has demonstrated additive effects when combined with other antimitotic agents to reduce the proliferation of various solid tumor, lymphoma, or lung cancer cell lines.{24892}
Brand:CaymanSKU:21262 -Out of stock
Vinorelbine is a semi-synthetic vinca alkaloid with microtubule destabilizing activity.{24892,28232} It inhibits microtubule polymerization and blocks mitosis at the metaphase/anaphase transition, preventing HeLa cell proliferation with an IC50 value of 1.25 nM.{33560} In in vitro and in vivo models, vinorelbine has demonstrated additive effects when combined with other antimitotic agents to reduce the proliferation of various solid tumor, lymphoma, or lung cancer cell lines.{24892}
Brand:CaymanSKU:21262 -Out of stock
Vinorelbine is a semi-synthetic vinca alkaloid with microtubule destabilizing activity.{24892,28232} It inhibits microtubule polymerization and blocks mitosis at the metaphase/anaphase transition, preventing HeLa cell proliferation with an IC50 value of 1.25 nM.{33560} In in vitro and in vivo models, vinorelbine has demonstrated additive effects when combined with other antimitotic agents to reduce the proliferation of various solid tumor, lymphoma, or lung cancer cell lines.{24892}
Brand:CaymanSKU:21262 -Out of stock
Vinorelbine is a semi-synthetic vinca alkaloid with microtubule destabilizing activity.{24892,28232} It inhibits microtubule polymerization and blocks mitosis at the metaphase/anaphase transition, preventing HeLa cell proliferation with an IC50 value of 1.25 nM.{33560} In in vitro and in vivo models, vinorelbine has demonstrated additive effects when combined with other antimitotic agents to reduce the proliferation of various solid tumor, lymphoma, or lung cancer cell lines.{24892}
Brand:CaymanSKU:21262 -Out of stock
Vinpocetine is a semi-synthetic alkaloid commonly used as an inhibitor of phosphodiesterase 1 (PDE1), blocking the hydrolysis of both cAMP and cGMP (Ki = 14 µM).{31354,31355} In addition to its use as a selective PDE1 inhibitor in basic research, vinpocetine has diverse cerebral and neurological effects in vivo.{31355} Vinpocetine also directly inhibits the kinase activity of IKKβ (IC50 = 17 µM in a cell-free system) and blocks TNF-α- and LPS-mediated activation of NF-κB in cells and in vivo.{31353}
Brand:CaymanSKU:19578 -Available on backorder
Vinpocetine is a semi-synthetic alkaloid commonly used as an inhibitor of phosphodiesterase 1 (PDE1), blocking the hydrolysis of both cAMP and cGMP (Ki = 14 µM).{31354,31355} In addition to its use as a selective PDE1 inhibitor in basic research, vinpocetine has diverse cerebral and neurological effects in vivo.{31355} Vinpocetine also directly inhibits the kinase activity of IKKβ (IC50 = 17 µM in a cell-free system) and blocks TNF-α- and LPS-mediated activation of NF-κB in cells and in vivo.{31353}
Brand:CaymanSKU:19578 -Available on backorder
Vinpocetine is a semi-synthetic alkaloid commonly used as an inhibitor of phosphodiesterase 1 (PDE1), blocking the hydrolysis of both cAMP and cGMP (Ki = 14 µM).{31354,31355} In addition to its use as a selective PDE1 inhibitor in basic research, vinpocetine has diverse cerebral and neurological effects in vivo.{31355} Vinpocetine also directly inhibits the kinase activity of IKKβ (IC50 = 17 µM in a cell-free system) and blocks TNF-α- and LPS-mediated activation of NF-κB in cells and in vivo.{31353}
Brand:CaymanSKU:19578 -Available on backorder
Vinpocetine is a semi-synthetic alkaloid commonly used as an inhibitor of phosphodiesterase 1 (PDE1), blocking the hydrolysis of both cAMP and cGMP (Ki = 14 µM).{31354,31355} In addition to its use as a selective PDE1 inhibitor in basic research, vinpocetine has diverse cerebral and neurological effects in vivo.{31355} Vinpocetine also directly inhibits the kinase activity of IKKβ (IC50 = 17 µM in a cell-free system) and blocks TNF-α- and LPS-mediated activation of NF-κB in cells and in vivo.{31353}
Brand:CaymanSKU:19578 -Available on backorder
Vinyl-L-NIO is a potent, selective inhibitor of nNOS. The Ki values for inhibition of nNOS, eNOS, and iNOS by vinyl-L-NIO are 100 nM, 12 and 60 µM, respectively, as determined using initial rate measurements.{6358} In the presence of NADPH and O2, vinyl-L-NIO irreversibly inactivates nNOS with a kinact of 0.078 min−1 and a Ki value of 90 nM. Vinyl-L-NIO does not inactivate iNOS. eNOS requires 20-fold higher concentrations of vinyl-L-NIO to obtain 75% the rate of inactivation seen with nNOS.{6358}
Brand:CaymanSKU:80330 - 10 mgAvailable on backorder
Vinyl-L-NIO is a potent, selective inhibitor of nNOS. The Ki values for inhibition of nNOS, eNOS, and iNOS by vinyl-L-NIO are 100 nM, 12 and 60 µM, respectively, as determined using initial rate measurements.{6358} In the presence of NADPH and O2, vinyl-L-NIO irreversibly inactivates nNOS with a kinact of 0.078 min−1 and a Ki value of 90 nM. Vinyl-L-NIO does not inactivate iNOS. eNOS requires 20-fold higher concentrations of vinyl-L-NIO to obtain 75% the rate of inactivation seen with nNOS.{6358}
Brand:CaymanSKU:80330 - 100 mgAvailable on backorder
Vinyl-L-NIO is a potent, selective inhibitor of nNOS. The Ki values for inhibition of nNOS, eNOS, and iNOS by vinyl-L-NIO are 100 nM, 12 and 60 µM, respectively, as determined using initial rate measurements.{6358} In the presence of NADPH and O2, vinyl-L-NIO irreversibly inactivates nNOS with a kinact of 0.078 min−1 and a Ki value of 90 nM. Vinyl-L-NIO does not inactivate iNOS. eNOS requires 20-fold higher concentrations of vinyl-L-NIO to obtain 75% the rate of inactivation seen with nNOS.{6358}
Brand:CaymanSKU:80330 - 5 mgAvailable on backorder
Vinyl-L-NIO is a potent, selective inhibitor of nNOS. The Ki values for inhibition of nNOS, eNOS, and iNOS by vinyl-L-NIO are 100 nM, 12 and 60 µM, respectively, as determined using initial rate measurements.{6358} In the presence of NADPH and O2, vinyl-L-NIO irreversibly inactivates nNOS with a kinact of 0.078 min−1 and a Ki value of 90 nM. Vinyl-L-NIO does not inactivate iNOS. eNOS requires 20-fold higher concentrations of vinyl-L-NIO to obtain 75% the rate of inactivation seen with nNOS.{6358}
Brand:CaymanSKU:80330 - 50 mgAvailable on backorder
Violacein is a bacterial metabolite originally isolated from C. violaceum that has antibacterial and antiprotozoal activities.{43926,43928} It is produced by C. violaceum as a purple pigment in response to N-hexanoyl homoserine lactone (Item No. 10007896), a property that has been modified to create a strain of C. violaceum used in detecting quorum-sensing molecules.{43927} Violacein is active against Gram-positive bacteria, including B. subtilis and S. aureus (MICs = 0.8 and 1.6 µM, respectively). It is also active against P. falciparum, including chloroquine-susceptible and -resistant strains (IC50s = 0.85 and 0.63 µM, respectively).{43928} It reduces parasitemia in a mouse model of nonlethal P. chabaudi chabaudi infection when administered at a dose of 7.5 mg/kg and increases survival in a mouse model of lethal P. chabaudi chabaudi infection. Violacein permeabilizes the cytoplasmic membrane of bacterial cells but does not affect the cell wall.{43926}
Brand:CaymanSKU:27959 - 1 mgAvailable on backorder
Vipadenant is a selective adenosine 2A (A2A) receptor antagonist with Ki values of 1.3, 68, 63, and 1,005 nM for A2A, A1, A2B, and A3 receptors, respectively, in a radioligand binding assay.{38172} It acts as a functional antagonist of human recombinant A2A (KA = 0.58 nM) in a calcium mobilization-based FLIPR assay. Vipadenant also reverses haloperidol-induced hypolocomotion in mice and rats. Formulations containing vipadenant are under clinical investigation for the treatment of symptoms associated with Parkinson’s disease.{38172,38173}
Brand:CaymanSKU:20239 -Available on backorder
Vipadenant is a selective adenosine 2A (A2A) receptor antagonist with Ki values of 1.3, 68, 63, and 1,005 nM for A2A, A1, A2B, and A3 receptors, respectively, in a radioligand binding assay.{38172} It acts as a functional antagonist of human recombinant A2A (KA = 0.58 nM) in a calcium mobilization-based FLIPR assay. Vipadenant also reverses haloperidol-induced hypolocomotion in mice and rats. Formulations containing vipadenant are under clinical investigation for the treatment of symptoms associated with Parkinson’s disease.{38172,38173}
Brand:CaymanSKU:20239 -Available on backorder
Vipadenant is a selective adenosine 2A (A2A) receptor antagonist with Ki values of 1.3, 68, 63, and 1,005 nM for A2A, A1, A2B, and A3 receptors, respectively, in a radioligand binding assay.{38172} It acts as a functional antagonist of human recombinant A2A (KA = 0.58 nM) in a calcium mobilization-based FLIPR assay. Vipadenant also reverses haloperidol-induced hypolocomotion in mice and rats. Formulations containing vipadenant are under clinical investigation for the treatment of symptoms associated with Parkinson’s disease.{38172,38173}
Brand:CaymanSKU:20239 -Available on backorder
Virginiamycin complex contains two streptogramin antibiotics, virginiamycin M1 (75%; Item No. 9002172) and virginiamycin S1 (25%; Item No. 17455), produced by S. virginiae. As a complex, the two antibiotics act synergistically to irreversibly inhibit protein synthesis in bacteria.{23008} When given to livestock, virginiamycin improves growth.{23010} Virginiamycin complex is also used in fuel ethanol fermenters to prevent to control bacteria competing with yeast for nutrients.{23009}
Brand:CaymanSKU:- Virginiamycin complex contains two streptogramin antibiotics, virginiamycin M1 (75%; Item No. 9002172) and virginiamycin S1 (25%; Item No. 17455), produced by S. virginiae. As a complex, the two antibiotics act synergistically to irreversibly inhibit protein synthesis in bacteria.{23008} When given to livestock, virginiamycin improves growth.{23010} Virginiamycin complex is also used in fuel ethanol fermenters to prevent to control bacteria competing with yeast for nutrients.{23009}
Brand:CaymanSKU:- Virginiamycin complex contains two streptogramin antibiotics, virginiamycin M1 (75%; Item No. 9002172) and virginiamycin S1 (25%; Item No. 17455), produced by S. virginiae. As a complex, the two antibiotics act synergistically to irreversibly inhibit protein synthesis in bacteria.{23008} When given to livestock, virginiamycin improves growth.{23010} Virginiamycin complex is also used in fuel ethanol fermenters to prevent to control bacteria competing with yeast for nutrients.{23009}
Brand:CaymanSKU:-
Virginiamycin M1 is a macrolide antibiotic. It is a member of the streptogramin A group of antibiotics, which bind the 50S ribosomal subunit at the peptidyl transferase center to inhibit initiation and translocation.{27765} They show good bactericidal activity against methicillin-resistant S. aureus (MRSA), although resistance in MRSA is conferred by the cfr gene.{27765,28231} Virginiamycin M1 acts synergistically with virginiamycin S1 to irreversibly inhibit protein synthesis in bacteria.{23008}
Brand:CaymanSKU:9002172 - 25 mgAvailable on backorder
Virginiamycin M1 is a macrolide antibiotic. It is a member of the streptogramin A group of antibiotics, which bind the 50S ribosomal subunit at the peptidyl transferase center to inhibit initiation and translocation.{27765} They show good bactericidal activity against methicillin-resistant S. aureus (MRSA), although resistance in MRSA is conferred by the cfr gene.{27765,28231} Virginiamycin M1 acts synergistically with virginiamycin S1 to irreversibly inhibit protein synthesis in bacteria.{23008}
Brand:CaymanSKU:9002172 - 5 mgAvailable on backorder
Virginiamycin S1 is a macrolide antibiotic that is a component of the virginiamycin complex (Item No. 14503), which also contains virginiamycin M1 (Item No. 9002172).{39373} It is a member of the streptogramin B group of antibiotics, which bind the 50S ribosomal subunit at the peptidyl transferase center to inhibit initiation and translocation.{27765} They show good bactericidal activity against methicillin-resistant S. aureus (MRSA), although resistance in MRSA is conferred by the cfr gene.{27765,28231} Virginiamycin S1 acts synergistically with virginiamycin M1 to irreversibly inhibit protein synthesis in bacteria.{23008}
Brand:CaymanSKU:-Available on backorder
Virginiamycin S1 is a macrolide antibiotic that is a component of the virginiamycin complex (Item No. 14503), which also contains virginiamycin M1 (Item No. 9002172).{39373} It is a member of the streptogramin B group of antibiotics, which bind the 50S ribosomal subunit at the peptidyl transferase center to inhibit initiation and translocation.{27765} They show good bactericidal activity against methicillin-resistant S. aureus (MRSA), although resistance in MRSA is conferred by the cfr gene.{27765,28231} Virginiamycin S1 acts synergistically with virginiamycin M1 to irreversibly inhibit protein synthesis in bacteria.{23008}
Brand:CaymanSKU:-Available on backorder
Viridicatin is a fungal metabolite isolated from various Penicillium species.{31092, 34275} This agent exhibits in vitro antibiotic activity against M. tuberculosis (1:15,000 dilution) but no activity against other tested bacterial strains.{34275}
Brand:CaymanSKU:21763 -Out of stock
Viridicatin is a fungal metabolite isolated from various Penicillium species.{31092, 34275} This agent exhibits in vitro antibiotic activity against M. tuberculosis (1:15,000 dilution) but no activity against other tested bacterial strains.{34275}
Brand:CaymanSKU:21763 -Out of stock
Viridicatol is a fungal metabolite that has been found in various Penicillium species as well as Phoma.{43044,43045} It suppresses the expression of COX-2 and inducible nitric oxide synthase (iNOS) and inhibits production of nitric oxide and prostaglandin E2 (PGE2) in LPS-stimulated RAW 264.7 and BV2 cells.{43046} It also inhibits NF-κB DNA-binding activity, nuclear translocation of NF-κB p65 and p50 heterodimers, and blocks degradation of inhibitor of kappa B α (IκBα) in the cytoplasm of LPS-stimulated RAW 264.7 and BV2 cells. Viridicatol inhibits the growth of F. graminearum in a disc assay.{43045} It also inhibits protein tyrosine phosphatase 1B (PTB1B) in vitro (IC50 = 64 μM).{43047}
Brand:CaymanSKU:25206 - 1 mgAvailable on backorder
Viridicatol is a fungal metabolite that has been found in various Penicillium species as well as Phoma.{43044,43045} It suppresses the expression of COX-2 and inducible nitric oxide synthase (iNOS) and inhibits production of nitric oxide and prostaglandin E2 (PGE2) in LPS-stimulated RAW 264.7 and BV2 cells.{43046} It also inhibits NF-κB DNA-binding activity, nuclear translocation of NF-κB p65 and p50 heterodimers, and blocks degradation of inhibitor of kappa B α (IκBα) in the cytoplasm of LPS-stimulated RAW 264.7 and BV2 cells. Viridicatol inhibits the growth of F. graminearum in a disc assay.{43045} It also inhibits protein tyrosine phosphatase 1B (PTB1B) in vitro (IC50 = 64 μM).{43047}
Brand:CaymanSKU:25206 - 5 mgAvailable on backorder
Viridicatumtoxin in a mycotoxin originally isolated from Penicillium that has diverse biological activities, including antimicrobial, cytotoxic, and toxic properties.{36724,30257,36725} It inhibits the growth of B. subtilis, M. luteus, C. perfringens, B. fragilis, and methicillin-resistant S. aureus (MRSA; MICs = 0.39-1.56 µg/ml), as well as C. albicans, S. cerevisiae, M. racemosus, A. niger, and P. chrysogenum (MICs = 6.2-25 µg/ml), but has no activity against M. smegmatis, E. coli, K. pneumoniae, P. aeruginosa, or S. marcescens (MICs = >100 µg/ml).{36725} Viridicatumtoxin inhibits the production of polyprenyl alcohols by S. aureus undecaprenyl pyrophosphate (UPP) synthase, E. coli octaprenyl pyrophosphate synthase (OPS), and S. cerevisiae dehydrodolichyl pyrophosphate (DedoIPP) synthase in vitro (IC50s = 3.1, 21, and 71 µM, respectively). It has cytotoxic effects against human Jurkat T (IC50 = 4.92 µM), chronic lymphocytic leukemia (CLL; LC50 = 0.7-3.5 nM), and bone marrow-derived HS-5 stromal cells.{30257,36725} Viridicatumtoxin is toxic to rats and mice when administered intraperitoneally (LD50s = 80 and 90 mg/kg, respectively) and to rats when administered via gastric intubation (LD50 = 122.4 mg/kg), but not to rats or mice when administered orally or through subcutaneous injection.{36724,36726}
Brand:CaymanSKU:25480 - 1 mgAvailable on backorder
Viridicatumtoxin in a mycotoxin originally isolated from Penicillium that has diverse biological activities, including antimicrobial, cytotoxic, and toxic properties.{36724,30257,36725} It inhibits the growth of B. subtilis, M. luteus, C. perfringens, B. fragilis, and methicillin-resistant S. aureus (MRSA; MICs = 0.39-1.56 µg/ml), as well as C. albicans, S. cerevisiae, M. racemosus, A. niger, and P. chrysogenum (MICs = 6.2-25 µg/ml), but has no activity against M. smegmatis, E. coli, K. pneumoniae, P. aeruginosa, or S. marcescens (MICs = >100 µg/ml).{36725} Viridicatumtoxin inhibits the production of polyprenyl alcohols by S. aureus undecaprenyl pyrophosphate (UPP) synthase, E. coli octaprenyl pyrophosphate synthase (OPS), and S. cerevisiae dehydrodolichyl pyrophosphate (DedoIPP) synthase in vitro (IC50s = 3.1, 21, and 71 µM, respectively). It has cytotoxic effects against human Jurkat T (IC50 = 4.92 µM), chronic lymphocytic leukemia (CLL; LC50 = 0.7-3.5 nM), and bone marrow-derived HS-5 stromal cells.{30257,36725} Viridicatumtoxin is toxic to rats and mice when administered intraperitoneally (LD50s = 80 and 90 mg/kg, respectively) and to rats when administered via gastric intubation (LD50 = 122.4 mg/kg), but not to rats or mice when administered orally or through subcutaneous injection.{36724,36726}
Brand:CaymanSKU:25480 - 5 mgAvailable on backorder
Viridiol is a fungal steroid that demonstrates phytotoxic activity.{31277} It is a metabolite of the fungistatic compound, viridin. Both viridin and viridiol are reported to inhibit PI3K.{31278}
Brand:CaymanSKU:19607 -Available on backorder
Viridiol is a fungal steroid that demonstrates phytotoxic activity.{31277} It is a metabolite of the fungistatic compound, viridin. Both viridin and viridiol are reported to inhibit PI3K.{31278}
Brand:CaymanSKU:19607 -Available on backorder
Virstatin is an inhibitor of the ToxT transcriptional regulator of V. cholerae, which regulates transcription of virulence factors that enable intestinal colonization.{40638} It inhibits ToxT dimerization and decreases expression of cholera toxin (CT) and toxin coregulated pilus (TCP) when used at a concentration of 50 μM but virstatin does not inhibit growth of V. cholerae at this concentration (MBCs = 600 and 1,200 μM for O395 and C6706 strains, respectively).{40638,40639} Virstatin administration protects infant mice (5 to 6 days old) from intestinal colonization by ToxT-dependent V. cholerae but not from strains that colonize via non-ToxT-dependent mechanisms. Virstatin (100 μM) inhibits biofilm formation by A. baumannii by 38% under static conditions, which is at a lower concentration than that which inhibits growth (MIC = 1.6 mM).{40640} It decreases the motility of 60% of 30 mobile A. baumannii strains. Virstatin also binds to the accessory cholera enterotoxin (Ace) from V. cholerae (Ka = 9 x 104 M-1; Kd = 11 µM).{40641}
Brand:CaymanSKU:21176 -Out of stock
Virstatin is an inhibitor of the ToxT transcriptional regulator of V. cholerae, which regulates transcription of virulence factors that enable intestinal colonization.{40638} It inhibits ToxT dimerization and decreases expression of cholera toxin (CT) and toxin coregulated pilus (TCP) when used at a concentration of 50 μM but virstatin does not inhibit growth of V. cholerae at this concentration (MBCs = 600 and 1,200 μM for O395 and C6706 strains, respectively).{40638,40639} Virstatin administration protects infant mice (5 to 6 days old) from intestinal colonization by ToxT-dependent V. cholerae but not from strains that colonize via non-ToxT-dependent mechanisms. Virstatin (100 μM) inhibits biofilm formation by A. baumannii by 38% under static conditions, which is at a lower concentration than that which inhibits growth (MIC = 1.6 mM).{40640} It decreases the motility of 60% of 30 mobile A. baumannii strains. Virstatin also binds to the accessory cholera enterotoxin (Ace) from V. cholerae (Ka = 9 x 104 M-1; Kd = 11 µM).{40641}
Brand:CaymanSKU:21176 -Out of stock
Virstatin is an inhibitor of the ToxT transcriptional regulator of V. cholerae, which regulates transcription of virulence factors that enable intestinal colonization.{40638} It inhibits ToxT dimerization and decreases expression of cholera toxin (CT) and toxin coregulated pilus (TCP) when used at a concentration of 50 μM but virstatin does not inhibit growth of V. cholerae at this concentration (MBCs = 600 and 1,200 μM for O395 and C6706 strains, respectively).{40638,40639} Virstatin administration protects infant mice (5 to 6 days old) from intestinal colonization by ToxT-dependent V. cholerae but not from strains that colonize via non-ToxT-dependent mechanisms. Virstatin (100 μM) inhibits biofilm formation by A. baumannii by 38% under static conditions, which is at a lower concentration than that which inhibits growth (MIC = 1.6 mM).{40640} It decreases the motility of 60% of 30 mobile A. baumannii strains. Virstatin also binds to the accessory cholera enterotoxin (Ace) from V. cholerae (Ka = 9 x 104 M-1; Kd = 11 µM).{40641}
Brand:CaymanSKU:21176 -Out of stock
Virustomycin A is a macrolide antibiotic originally isolated from Streptomyces.{51046,51054} It is active against infectious and plant pathogenic fungi, including T. vaginalis and P. oryzae (MICs = 6.25 and 12.5 µg/ml, respectively), as well as the parasite T. foetus (MIC = 25 µg/ml).{51046} It also decreases plaque formation by RNA and DNA viruses (ED50 = 0.0003 µg/ml for all). Virustomycin A is active against the GUTat 3.1 strain of T. brucei brucei, but not the STIB900 strain of T. brucei rhodesiense (IC50s = 0.45 and 480 ng/ml, respectively), and induces cytotoxicity in human MRC-5 cells with an IC50 value of 80 ng/ml.{24919} It inhibits RNA, DNA, and protein synthesis in T. foetus.{51054}
Brand:CaymanSKU:27736 - 1 mgAvailable on backorder
Virustomycin A is a macrolide antibiotic originally isolated from Streptomyces.{51046,51054} It is active against infectious and plant pathogenic fungi, including T. vaginalis and P. oryzae (MICs = 6.25 and 12.5 µg/ml, respectively), as well as the parasite T. foetus (MIC = 25 µg/ml).{51046} It also decreases plaque formation by RNA and DNA viruses (ED50 = 0.0003 µg/ml for all). Virustomycin A is active against the GUTat 3.1 strain of T. brucei brucei, but not the STIB900 strain of T. brucei rhodesiense (IC50s = 0.45 and 480 ng/ml, respectively), and induces cytotoxicity in human MRC-5 cells with an IC50 value of 80 ng/ml.{24919} It inhibits RNA, DNA, and protein synthesis in T. foetus.{51054}
Brand:CaymanSKU:27736 - 5 mgAvailable on backorder
Virustomycin A is a macrolide antibiotic originally isolated from Streptomyces.{51046,51054} It is active against infectious and plant pathogenic fungi, including T. vaginalis and P. oryzae (MICs = 6.25 and 12.5 µg/ml, respectively), as well as the parasite T. foetus (MIC = 25 µg/ml).{51046} It also decreases plaque formation by RNA and DNA viruses (ED50 = 0.0003 µg/ml for all). Virustomycin A is active against the GUTat 3.1 strain of T. brucei brucei, but not the STIB900 strain of T. brucei rhodesiense (IC50s = 0.45 and 480 ng/ml, respectively), and induces cytotoxicity in human MRC-5 cells with an IC50 value of 80 ng/ml.{24919} It inhibits RNA, DNA, and protein synthesis in T. foetus.{51054}
Brand:CaymanSKU:27736 - 500 µgAvailable on backorder
Vitamin A, also known as all-trans retinol, is an intermediate in retinol metabolism in animals. It is metabolized to retinoic acid (Item No. 11017), a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). RAR and RXR heterodimerize and act as ligand-dependent transcriptional regulators, with roles in development, reproduction, immunity, organogenesis, and cancer.{20155,20156,20158}
Brand:CaymanSKU:20241 -Available on backorder
Vitamin A, also known as all-trans retinol, is an intermediate in retinol metabolism in animals. It is metabolized to retinoic acid (Item No. 11017), a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). RAR and RXR heterodimerize and act as ligand-dependent transcriptional regulators, with roles in development, reproduction, immunity, organogenesis, and cancer.{20155,20156,20158}
Brand:CaymanSKU:20241 -Available on backorder
Vitamin A, also known as all-trans retinol, is an intermediate in retinol metabolism in animals. It is metabolized to retinoic acid (Item No. 11017), a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). RAR and RXR heterodimerize and act as ligand-dependent transcriptional regulators, with roles in development, reproduction, immunity, organogenesis, and cancer.{20155,20156,20158}
Brand:CaymanSKU:20241 -Available on backorder
Vitamin A, also known as all-trans retinol, is an intermediate in retinol metabolism in animals. It is metabolized to retinoic acid (Item No. 11017), a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). RAR and RXR heterodimerize and act as ligand-dependent transcriptional regulators, with roles in development, reproduction, immunity, organogenesis, and cancer.{20155,20156,20158}
Brand:CaymanSKU:20241 -Available on backorder
The primary synthesis of functional vitamin D begins in the skin, where a cholesterol by-product acted upon by UV light forms vitamin D3. Vitamin D3 is carried through the bloodstream, attached to the vitamin D binding protein, to the liver where it is converted to 25-hydroxy vitamin D3 (25(OH)D3). This product is then transported to the kidney where it is further converted to 1,25-dihydroxycholecalciferol (1,25(OH)2D3), the biologically active form. Active 1,25(OH)2D3 is very short-lived and is rapidly metabolized to its deactivated forms. Vitamin D Immunoassay: Accurate Vitamin D measurement in plasma or serum Cayman’s Vitamin D EIA Kit is a competitive assay that can be used for Vitamin D quantification in plasma or serum. Because of the short half-life of the biologically active 1,25(OH)D form, this Vitamin D assay primarily detects the more metabolically stable forms, 25(OH)D3 and 25(OH)D2. Accurate detection of these forms requires that they be displaced from the vitamin D binding protein prior to measurement. A simple, acetone-based purification protocol is included as the initial procedure of the Vitamin D assay kit for this purpose.
Brand:CaymanSKU:501050 - 480 solid wellsAvailable on backorder
The primary synthesis of functional vitamin D begins in the skin, where a cholesterol by-product acted upon by UV light forms vitamin D3. Vitamin D3 is carried through the bloodstream, attached to the vitamin D binding protein, to the liver where it is converted to 25-hydroxy vitamin D3 (25(OH)D3). This product is then transported to the kidney where it is further converted to 1,25-dihydroxycholecalciferol (1,25(OH)2D3), the biologically active form. Active 1,25(OH)2D3 is very short-lived and is rapidly metabolized to its deactivated forms. Vitamin D Immunoassay: Accurate Vitamin D measurement in plasma or serum Cayman’s Vitamin D EIA Kit is a competitive assay that can be used for Vitamin D quantification in plasma or serum. Because of the short half-life of the biologically active 1,25(OH)D form, this Vitamin D assay primarily detects the more metabolically stable forms, 25(OH)D3 and 25(OH)D2. Accurate detection of these forms requires that they be displaced from the vitamin D binding protein prior to measurement. A simple, acetone-based purification protocol is included as the initial procedure of the Vitamin D assay kit for this purpose.
Brand:CaymanSKU:501050 - 480 strip wellsAvailable on backorder
The primary synthesis of functional vitamin D begins in the skin, where a cholesterol by-product acted upon by UV light forms vitamin D3. Vitamin D3 is carried through the bloodstream, attached to the vitamin D binding protein, to the liver where it is converted to 25-hydroxy vitamin D3 (25(OH)D3). This product is then transported to the kidney where it is further converted to 1,25-dihydroxycholecalciferol (1,25(OH)2D3), the biologically active form. Active 1,25(OH)2D3 is very short-lived and is rapidly metabolized to its deactivated forms. Vitamin D Immunoassay: Accurate Vitamin D measurement in plasma or serum Cayman’s Vitamin D EIA Kit is a competitive assay that can be used for Vitamin D quantification in plasma or serum. Because of the short half-life of the biologically active 1,25(OH)D form, this Vitamin D assay primarily detects the more metabolically stable forms, 25(OH)D3 and 25(OH)D2. Accurate detection of these forms requires that they be displaced from the vitamin D binding protein prior to measurement. A simple, acetone-based purification protocol is included as the initial procedure of the Vitamin D assay kit for this purpose.
Brand:CaymanSKU:501050 - 96 solid wellsAvailable on backorder
The primary synthesis of functional vitamin D begins in the skin, where a cholesterol by-product acted upon by UV light forms vitamin D3. Vitamin D3 is carried through the bloodstream, attached to the vitamin D binding protein, to the liver where it is converted to 25-hydroxy vitamin D3 (25(OH)D3). This product is then transported to the kidney where it is further converted to 1,25-dihydroxycholecalciferol (1,25(OH)2D3), the biologically active form. Active 1,25(OH)2D3 is very short-lived and is rapidly metabolized to its deactivated forms. Vitamin D Immunoassay: Accurate Vitamin D measurement in plasma or serum Cayman’s Vitamin D EIA Kit is a competitive assay that can be used for Vitamin D quantification in plasma or serum. Because of the short half-life of the biologically active 1,25(OH)D form, this Vitamin D assay primarily detects the more metabolically stable forms, 25(OH)D3 and 25(OH)D2. Accurate detection of these forms requires that they be displaced from the vitamin D binding protein prior to measurement. A simple, acetone-based purification protocol is included as the initial procedure of the Vitamin D assay kit for this purpose.
Brand:CaymanSKU:501050 - 96 strip wellsAvailable on backorder
Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer and immunity.{15096,19429} Vitamin D may be obtained from many dietary sources, including eggs and fish, and is synthesized in the skin by the conversion of 7-dehydrocholesterol to vitamin D3 by ultraviolet light.{19039} Vitamin D2 is produced in fungi, including yeast, and invertebrates from ergosterol in response to ultraviolet radiation. In vertebrates as well as host organisms, vitamin D2 is metabolized first to 25-hydroxyvitamin D2 and subsequently to the active 1,25-dihydroxyvitamin D2.{15096,21018} Differences in the metabolism and action of vitamin D2 vs. vitamin D3 in mammals is a current topic of research interest.{21018}
Brand:CaymanSKU:11791 - 1 gAvailable on backorder
Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer and immunity.{15096,19429} Vitamin D may be obtained from many dietary sources, including eggs and fish, and is synthesized in the skin by the conversion of 7-dehydrocholesterol to vitamin D3 by ultraviolet light.{19039} Vitamin D2 is produced in fungi, including yeast, and invertebrates from ergosterol in response to ultraviolet radiation. In vertebrates as well as host organisms, vitamin D2 is metabolized first to 25-hydroxyvitamin D2 and subsequently to the active 1,25-dihydroxyvitamin D2.{15096,21018} Differences in the metabolism and action of vitamin D2 vs. vitamin D3 in mammals is a current topic of research interest.{21018}
Brand:CaymanSKU:11791 - 10 gAvailable on backorder
Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer and immunity.{15096,19429} Vitamin D may be obtained from many dietary sources, including eggs and fish, and is synthesized in the skin by the conversion of 7-dehydrocholesterol to vitamin D3 by ultraviolet light.{19039} Vitamin D2 is produced in fungi, including yeast, and invertebrates from ergosterol in response to ultraviolet radiation. In vertebrates as well as host organisms, vitamin D2 is metabolized first to 25-hydroxyvitamin D2 and subsequently to the active 1,25-dihydroxyvitamin D2.{15096,21018} Differences in the metabolism and action of vitamin D2 vs. vitamin D3 in mammals is a current topic of research interest.{21018}
Brand:CaymanSKU:11791 - 5 gAvailable on backorder
Vitamin D3 is a biologically inactive precursor to calcitriol (Item No. 71820) that is converted to active metabolites in vivo.{23284,15096} Vitamin D3 is obtained from dietary sources, including fish, or formed in the epidermis via photolytic conversion of 7-dehydro cholesterol (Item No. 14612) to previtamin D3 by UVB radiation, followed by isomerization to vitamin D3.{19039,23286} Vitamin D3 can then be converted to 25-hydroxy vitamin D3 (Item No. 9000683) in the liver by the cytochrome P450 (CYP) isoform CYP2R1 before being converted to calcitriol by CYP27B1 in the kidney.{15096,19039} Formulations containing vitamin D3 have been used in the treatment of osteoporosis.
Brand:CaymanSKU:11792 - 1 gAvailable on backorder
Vitamin D3 is a biologically inactive precursor to calcitriol (Item No. 71820) that is converted to active metabolites in vivo.{23284,15096} Vitamin D3 is obtained from dietary sources, including fish, or formed in the epidermis via photolytic conversion of 7-dehydro cholesterol (Item No. 14612) to previtamin D3 by UVB radiation, followed by isomerization to vitamin D3.{19039,23286} Vitamin D3 can then be converted to 25-hydroxy vitamin D3 (Item No. 9000683) in the liver by the cytochrome P450 (CYP) isoform CYP2R1 before being converted to calcitriol by CYP27B1 in the kidney.{15096,19039} Formulations containing vitamin D3 have been used in the treatment of osteoporosis.
Brand:CaymanSKU:11792 - 10 gAvailable on backorder
Vitamin D3 is a biologically inactive precursor to calcitriol (Item No. 71820) that is converted to active metabolites in vivo.{23284,15096} Vitamin D3 is obtained from dietary sources, including fish, or formed in the epidermis via photolytic conversion of 7-dehydro cholesterol (Item No. 14612) to previtamin D3 by UVB radiation, followed by isomerization to vitamin D3.{19039,23286} Vitamin D3 can then be converted to 25-hydroxy vitamin D3 (Item No. 9000683) in the liver by the cytochrome P450 (CYP) isoform CYP2R1 before being converted to calcitriol by CYP27B1 in the kidney.{15096,19039} Formulations containing vitamin D3 have been used in the treatment of osteoporosis.
Brand:CaymanSKU:11792 - 5 gAvailable on backorder
Vitamin D3-d7 is intended for use as an internal standard for the quantification of vitamin D3 (Item No. 11792) by GC- or LC-MS. Vitamin D3 is a biologically inactive precursor to calcitriol (Item No. 71820) that is converted to active metabolites in vivo.{23284,15096} Vitamin D3 is obtained from dietary sources, including fish, or formed in the epidermis via photolytic conversion of 7-dehydro cholesterol (Item No. 14612) to previtamin D3 by UVB radiation, followed by isomerization to vitamin D3.{19039,23286} Vitamin D3 can then be converted to 25-hydroxy vitamin D3 (Item No. 9000683) in the liver by the cytochrome P450 (CYP) isoform CYP2R1 before being converted to calcitriol by CYP27B1 in the kidney.{15096,19039} Formulations containing vitamin D3 have been used in the treatment of osteoporosis.
Brand:CaymanSKU:25427 - 500 µgAvailable on backorder